-- dump date 20140619_225301 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1116391000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1116391000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1116391000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391000004 Walker A motif; other site 1116391000005 ATP binding site [chemical binding]; other site 1116391000006 Walker B motif; other site 1116391000007 arginine finger; other site 1116391000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1116391000009 DnaA box-binding interface [nucleotide binding]; other site 1116391000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1116391000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1116391000012 putative DNA binding surface [nucleotide binding]; other site 1116391000013 dimer interface [polypeptide binding]; other site 1116391000014 beta-clamp/clamp loader binding surface; other site 1116391000015 beta-clamp/translesion DNA polymerase binding surface; other site 1116391000016 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1116391000017 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1116391000018 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391000019 ATP binding site [chemical binding]; other site 1116391000020 Mg2+ binding site [ion binding]; other site 1116391000021 G-X-G motif; other site 1116391000022 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1116391000023 anchoring element; other site 1116391000024 dimer interface [polypeptide binding]; other site 1116391000025 ATP binding site [chemical binding]; other site 1116391000026 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1116391000027 active site 1116391000028 putative metal-binding site [ion binding]; other site 1116391000029 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1116391000030 DNA gyrase subunit A; Validated; Region: PRK05560 1116391000031 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1116391000032 CAP-like domain; other site 1116391000033 active site 1116391000034 primary dimer interface [polypeptide binding]; other site 1116391000035 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1116391000036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1116391000037 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1116391000038 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1116391000039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1116391000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1116391000041 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1116391000042 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1116391000043 Zn2+ binding site [ion binding]; other site 1116391000044 Mg2+ binding site [ion binding]; other site 1116391000045 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1116391000046 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1116391000047 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1116391000048 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1116391000049 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1116391000050 active site 1116391000051 multimer interface [polypeptide binding]; other site 1116391000052 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1116391000053 predicted active site [active] 1116391000054 catalytic triad [active] 1116391000055 seryl-tRNA synthetase; Provisional; Region: PRK05431 1116391000056 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1116391000057 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1116391000058 dimer interface [polypeptide binding]; other site 1116391000059 active site 1116391000060 motif 1; other site 1116391000061 motif 2; other site 1116391000062 motif 3; other site 1116391000063 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1116391000064 Part of AAA domain; Region: AAA_19; pfam13245 1116391000065 Family description; Region: UvrD_C_2; pfam13538 1116391000066 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1116391000067 active site 1116391000068 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 1116391000069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391000070 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391000071 DNA binding residues [nucleotide binding] 1116391000072 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1116391000073 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1116391000074 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1116391000075 nucleoside/Zn binding site; other site 1116391000076 dimer interface [polypeptide binding]; other site 1116391000077 catalytic motif [active] 1116391000078 PilZ domain; Region: PilZ; pfam07238 1116391000079 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1116391000080 amidase catalytic site [active] 1116391000081 Zn binding residues [ion binding]; other site 1116391000082 substrate binding site [chemical binding]; other site 1116391000083 GTP-binding protein YchF; Reviewed; Region: PRK09601 1116391000084 YchF GTPase; Region: YchF; cd01900 1116391000085 G1 box; other site 1116391000086 GTP/Mg2+ binding site [chemical binding]; other site 1116391000087 Switch I region; other site 1116391000088 G2 box; other site 1116391000089 Switch II region; other site 1116391000090 G3 box; other site 1116391000091 G4 box; other site 1116391000092 G5 box; other site 1116391000093 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1116391000094 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1116391000095 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1116391000096 RF-1 domain; Region: RF-1; pfam00472 1116391000097 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1116391000098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391000099 S-adenosylmethionine binding site [chemical binding]; other site 1116391000100 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 1116391000101 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1116391000102 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1116391000103 Predicted membrane protein [Function unknown]; Region: COG1971 1116391000104 Domain of unknown function DUF; Region: DUF204; pfam02659 1116391000105 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1116391000106 hypothetical protein; Provisional; Region: PRK13690 1116391000107 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1116391000108 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1116391000109 dimer interface [polypeptide binding]; other site 1116391000110 active site 1116391000111 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1116391000112 folate binding site [chemical binding]; other site 1116391000113 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1116391000114 active site 1116391000115 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1116391000116 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1116391000117 active site 1116391000118 homodimer interface [polypeptide binding]; other site 1116391000119 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 1116391000120 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1116391000121 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1116391000122 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1116391000123 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1116391000124 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1116391000125 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1116391000126 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1116391000127 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1116391000128 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1116391000129 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1116391000130 beta subunit interaction interface [polypeptide binding]; other site 1116391000131 Walker A motif; other site 1116391000132 ATP binding site [chemical binding]; other site 1116391000133 Walker B motif; other site 1116391000134 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1116391000135 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1116391000136 core domain interface [polypeptide binding]; other site 1116391000137 delta subunit interface [polypeptide binding]; other site 1116391000138 epsilon subunit interface [polypeptide binding]; other site 1116391000139 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1116391000140 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1116391000141 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1116391000142 alpha subunit interaction interface [polypeptide binding]; other site 1116391000143 Walker A motif; other site 1116391000144 ATP binding site [chemical binding]; other site 1116391000145 Walker B motif; other site 1116391000146 inhibitor binding site; inhibition site 1116391000147 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1116391000148 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1116391000149 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1116391000150 gamma subunit interface [polypeptide binding]; other site 1116391000151 epsilon subunit interface [polypeptide binding]; other site 1116391000152 LBP interface [polypeptide binding]; other site 1116391000153 NADH dehydrogenase subunit A; Validated; Region: PRK07756 1116391000154 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1116391000155 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1116391000156 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1116391000157 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 1116391000158 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1116391000159 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1116391000160 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1116391000161 4Fe-4S binding domain; Region: Fer4; pfam00037 1116391000162 4Fe-4S binding domain; Region: Fer4; cl02805 1116391000163 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 1116391000164 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 1116391000165 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 1116391000166 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1116391000167 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 1116391000168 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1116391000169 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1116391000170 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1116391000171 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1116391000172 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1116391000173 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391000174 MarR family; Region: MarR; pfam01047 1116391000175 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1116391000176 active site 1116391000177 catalytic residues [active] 1116391000178 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1116391000179 S-layer homology domain; Region: SLH; pfam00395 1116391000180 S-layer homology domain; Region: SLH; pfam00395 1116391000181 S-layer homology domain; Region: SLH; pfam00395 1116391000182 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1116391000183 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1116391000184 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1116391000185 hinge; other site 1116391000186 active site 1116391000187 stage II sporulation protein D; Region: spore_II_D; TIGR02870 1116391000188 Stage II sporulation protein; Region: SpoIID; pfam08486 1116391000189 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1116391000190 Peptidase family M23; Region: Peptidase_M23; pfam01551 1116391000191 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1116391000192 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1116391000193 MreB and similar proteins; Region: MreB_like; cd10225 1116391000194 nucleotide binding site [chemical binding]; other site 1116391000195 Mg binding site [ion binding]; other site 1116391000196 putative protofilament interaction site [polypeptide binding]; other site 1116391000197 RodZ interaction site [polypeptide binding]; other site 1116391000198 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1116391000199 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1116391000200 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1116391000201 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1116391000202 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1116391000203 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1116391000204 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 1116391000205 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1116391000206 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1116391000207 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1116391000208 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1116391000209 active site 1116391000210 substrate binding site [chemical binding]; other site 1116391000211 metal binding site [ion binding]; metal-binding site 1116391000212 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1116391000213 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 1116391000214 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1116391000215 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1116391000216 Mg++ binding site [ion binding]; other site 1116391000217 putative catalytic motif [active] 1116391000218 substrate binding site [chemical binding]; other site 1116391000219 S-layer homology domain; Region: SLH; pfam00395 1116391000220 S-layer homology domain; Region: SLH; pfam00395 1116391000221 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1116391000222 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1116391000223 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1116391000224 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1116391000225 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1116391000226 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1116391000227 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1116391000228 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391000229 Sensor protein DegS; Region: DegS; pfam05384 1116391000230 Histidine kinase; Region: HisKA_3; pfam07730 1116391000231 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1116391000232 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391000233 ATP binding site [chemical binding]; other site 1116391000234 Mg2+ binding site [ion binding]; other site 1116391000235 G-X-G motif; other site 1116391000236 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391000237 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391000238 active site 1116391000239 phosphorylation site [posttranslational modification] 1116391000240 intermolecular recognition site; other site 1116391000241 dimerization interface [polypeptide binding]; other site 1116391000242 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391000243 DNA binding residues [nucleotide binding] 1116391000244 dimerization interface [polypeptide binding]; other site 1116391000245 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1116391000246 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1116391000247 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1116391000248 ATP binding site [chemical binding]; other site 1116391000249 putative Mg++ binding site [ion binding]; other site 1116391000250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1116391000251 nucleotide binding region [chemical binding]; other site 1116391000252 ATP-binding site [chemical binding]; other site 1116391000253 comF family protein; Region: comF; TIGR00201 1116391000254 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1116391000255 active site 1116391000256 flagellar operon protein TIGR03826; Region: YvyF 1116391000257 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 1116391000258 FlgN protein; Region: FlgN; pfam05130 1116391000259 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1116391000260 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1116391000261 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1116391000262 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1116391000263 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1116391000264 flagellar assembly protein FliW; Provisional; Region: PRK13285 1116391000265 carbon storage regulator; Provisional; Region: PRK01712 1116391000266 flagellin; Provisional; Region: PRK12804 1116391000267 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1116391000268 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1116391000269 flagellin; Provisional; Region: PRK12804 1116391000270 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1116391000271 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1116391000272 FlaG protein; Region: FlaG; pfam03646 1116391000273 flagellar capping protein; Validated; Region: fliD; PRK07737 1116391000274 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1116391000275 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1116391000276 Flagellar protein FliS; Region: FliS; cl00654 1116391000277 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1116391000278 DNA-binding site [nucleotide binding]; DNA binding site 1116391000279 RNA-binding motif; other site 1116391000280 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1116391000281 30S subunit binding site; other site 1116391000282 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1116391000283 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1116391000284 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1116391000285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1116391000286 nucleotide binding region [chemical binding]; other site 1116391000287 ATP-binding site [chemical binding]; other site 1116391000288 peptide chain release factor 2; Provisional; Region: PRK06746 1116391000289 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1116391000290 RF-1 domain; Region: RF-1; pfam00472 1116391000291 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1116391000292 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1116391000293 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1116391000294 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1116391000295 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1116391000296 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1116391000297 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1116391000298 molybdopterin cofactor binding site; other site 1116391000299 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1116391000300 molybdopterin cofactor binding site; other site 1116391000301 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1116391000302 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1116391000303 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1116391000304 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1116391000305 heterotetramer interface [polypeptide binding]; other site 1116391000306 active site pocket [active] 1116391000307 cleavage site 1116391000308 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1116391000309 nucleotide binding site [chemical binding]; other site 1116391000310 N-acetyl-L-glutamate binding site [chemical binding]; other site 1116391000311 acetylornithine aminotransferase; Provisional; Region: PRK02627 1116391000312 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1116391000313 inhibitor-cofactor binding pocket; inhibition site 1116391000314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391000315 catalytic residue [active] 1116391000316 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1116391000317 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1116391000318 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1116391000319 argininosuccinate synthase; Provisional; Region: PRK13820 1116391000320 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1116391000321 ANP binding site [chemical binding]; other site 1116391000322 Substrate Binding Site II [chemical binding]; other site 1116391000323 Substrate Binding Site I [chemical binding]; other site 1116391000324 argininosuccinate lyase; Provisional; Region: PRK00855 1116391000325 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1116391000326 active sites [active] 1116391000327 tetramer interface [polypeptide binding]; other site 1116391000328 VanW like protein; Region: VanW; pfam04294 1116391000329 G5 domain; Region: G5; pfam07501 1116391000330 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1116391000331 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1116391000332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1116391000333 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 1116391000334 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1116391000335 Peptidase family M23; Region: Peptidase_M23; pfam01551 1116391000336 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1116391000337 C-terminal peptidase (prc); Region: prc; TIGR00225 1116391000338 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1116391000339 protein binding site [polypeptide binding]; other site 1116391000340 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1116391000341 Catalytic dyad [active] 1116391000342 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1116391000343 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1116391000344 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1116391000345 flagellar motor protein MotS; Reviewed; Region: PRK06925 1116391000346 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1116391000347 ligand binding site [chemical binding]; other site 1116391000348 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1116391000349 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1116391000350 excinuclease ABC subunit B; Provisional; Region: PRK05298 1116391000351 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1116391000352 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1116391000353 nucleotide binding region [chemical binding]; other site 1116391000354 ATP-binding site [chemical binding]; other site 1116391000355 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1116391000356 UvrB/uvrC motif; Region: UVR; pfam02151 1116391000357 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391000358 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391000359 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391000360 NAD(P) binding site [chemical binding]; other site 1116391000361 active site 1116391000362 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391000363 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1116391000364 MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738 1116391000365 hypothetical protein; Validated; Region: PRK07080 1116391000366 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391000367 FG-GAP repeat; Region: FG-GAP; pfam01839 1116391000368 Family description; Region: VCBS; pfam13517 1116391000369 FG-GAP repeat; Region: FG-GAP; pfam01839 1116391000370 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1116391000371 Peptidase family U32; Region: Peptidase_U32; pfam01136 1116391000372 Collagenase; Region: DUF3656; pfam12392 1116391000373 Peptidase family U32; Region: Peptidase_U32; pfam01136 1116391000374 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 1116391000375 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1116391000376 Walker A/P-loop; other site 1116391000377 ATP binding site [chemical binding]; other site 1116391000378 Q-loop/lid; other site 1116391000379 ABC transporter signature motif; other site 1116391000380 Walker B; other site 1116391000381 D-loop; other site 1116391000382 H-loop/switch region; other site 1116391000383 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1116391000384 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1116391000385 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1116391000386 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1116391000387 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1116391000388 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391000389 motif II; other site 1116391000390 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 1116391000391 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391000392 MarR family; Region: MarR; pfam01047 1116391000393 Coat F domain; Region: Coat_F; pfam07875 1116391000394 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1116391000395 PcrB family; Region: PcrB; pfam01884 1116391000396 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1116391000397 substrate binding site [chemical binding]; other site 1116391000398 putative active site [active] 1116391000399 dimer interface [polypeptide binding]; other site 1116391000400 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1116391000401 Part of AAA domain; Region: AAA_19; pfam13245 1116391000402 Family description; Region: UvrD_C_2; pfam13538 1116391000403 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1116391000404 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1116391000405 nucleotide binding pocket [chemical binding]; other site 1116391000406 K-X-D-G motif; other site 1116391000407 catalytic site [active] 1116391000408 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1116391000409 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1116391000410 Dimer interface [polypeptide binding]; other site 1116391000411 BRCT sequence motif; other site 1116391000412 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 1116391000413 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1116391000414 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1116391000415 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1116391000416 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1116391000417 Walker A/P-loop; other site 1116391000418 ATP binding site [chemical binding]; other site 1116391000419 Q-loop/lid; other site 1116391000420 ABC transporter signature motif; other site 1116391000421 Walker B; other site 1116391000422 D-loop; other site 1116391000423 H-loop/switch region; other site 1116391000424 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1116391000425 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1116391000426 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1116391000427 Hpr binding site; other site 1116391000428 active site 1116391000429 homohexamer subunit interaction site [polypeptide binding]; other site 1116391000430 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1116391000431 pyrophosphatase PpaX; Provisional; Region: PRK13288 1116391000432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391000433 motif II; other site 1116391000434 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1116391000435 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1116391000436 trimer interface [polypeptide binding]; other site 1116391000437 active site 1116391000438 substrate binding site [chemical binding]; other site 1116391000439 CoA binding site [chemical binding]; other site 1116391000440 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 1116391000441 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1116391000442 dimer interface [polypeptide binding]; other site 1116391000443 motif 1; other site 1116391000444 active site 1116391000445 motif 2; other site 1116391000446 motif 3; other site 1116391000447 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1116391000448 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1116391000449 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1116391000450 histidinol dehydrogenase; Region: hisD; TIGR00069 1116391000451 NAD binding site [chemical binding]; other site 1116391000452 dimerization interface [polypeptide binding]; other site 1116391000453 product binding site; other site 1116391000454 substrate binding site [chemical binding]; other site 1116391000455 zinc binding site [ion binding]; other site 1116391000456 catalytic residues [active] 1116391000457 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1116391000458 putative active site pocket [active] 1116391000459 4-fold oligomerization interface [polypeptide binding]; other site 1116391000460 metal binding residues [ion binding]; metal-binding site 1116391000461 3-fold/trimer interface [polypeptide binding]; other site 1116391000462 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1116391000463 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1116391000464 putative active site [active] 1116391000465 oxyanion strand; other site 1116391000466 catalytic triad [active] 1116391000467 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1116391000468 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1116391000469 substrate binding site [chemical binding]; other site 1116391000470 glutamase interaction surface [polypeptide binding]; other site 1116391000471 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1116391000472 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1116391000473 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1116391000474 metal binding site [ion binding]; metal-binding site 1116391000475 histidinol-phosphatase; Provisional; Region: PRK07328 1116391000476 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1116391000477 active site 1116391000478 dimer interface [polypeptide binding]; other site 1116391000479 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1116391000480 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1116391000481 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1116391000482 active site 1116391000483 TPR repeat; Region: TPR_11; pfam13414 1116391000484 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1116391000485 TPR motif; other site 1116391000486 binding surface 1116391000487 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1116391000488 TPR motif; other site 1116391000489 binding surface 1116391000490 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1116391000491 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1116391000492 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1116391000493 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1116391000494 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1116391000495 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1116391000496 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1116391000497 active site 1116391000498 Zn binding site [ion binding]; other site 1116391000499 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 1116391000500 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391000501 Interdomain contacts; other site 1116391000502 Cytokine receptor motif; other site 1116391000503 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1116391000504 active site 1116391000505 catalytic triad [active] 1116391000506 oxyanion hole [active] 1116391000507 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391000508 Interdomain contacts; other site 1116391000509 S-layer homology domain; Region: SLH; pfam00395 1116391000510 S-layer homology domain; Region: SLH; pfam00395 1116391000511 S-layer homology domain; Region: SLH; pfam00395 1116391000512 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1116391000513 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1116391000514 nucleotide binding site [chemical binding]; other site 1116391000515 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1116391000516 AAA domain; Region: AAA_33; pfam13671 1116391000517 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1116391000518 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1116391000519 phosphate binding site [ion binding]; other site 1116391000520 putative substrate binding pocket [chemical binding]; other site 1116391000521 dimer interface [polypeptide binding]; other site 1116391000522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1116391000523 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1116391000524 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1116391000525 dimerization domain swap beta strand [polypeptide binding]; other site 1116391000526 regulatory protein interface [polypeptide binding]; other site 1116391000527 active site 1116391000528 regulatory phosphorylation site [posttranslational modification]; other site 1116391000529 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391000530 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391000531 Bacterial Ig-like domain; Region: Big_5; pfam13205 1116391000532 Clp protease; Region: CLP_protease; pfam00574 1116391000533 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1116391000534 oligomer interface [polypeptide binding]; other site 1116391000535 active site residues [active] 1116391000536 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1116391000537 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1116391000538 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1116391000539 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1116391000540 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1116391000541 Phosphoglycerate kinase; Region: PGK; pfam00162 1116391000542 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1116391000543 substrate binding site [chemical binding]; other site 1116391000544 hinge regions; other site 1116391000545 ADP binding site [chemical binding]; other site 1116391000546 catalytic site [active] 1116391000547 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1116391000548 triosephosphate isomerase; Provisional; Region: PRK14565 1116391000549 substrate binding site [chemical binding]; other site 1116391000550 dimer interface [polypeptide binding]; other site 1116391000551 catalytic triad [active] 1116391000552 phosphoglyceromutase; Provisional; Region: PRK05434 1116391000553 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1116391000554 enolase; Provisional; Region: eno; PRK00077 1116391000555 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1116391000556 dimer interface [polypeptide binding]; other site 1116391000557 metal binding site [ion binding]; metal-binding site 1116391000558 substrate binding pocket [chemical binding]; other site 1116391000559 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 1116391000560 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 1116391000561 Esterase/lipase [General function prediction only]; Region: COG1647 1116391000562 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 1116391000563 ribonuclease R; Region: RNase_R; TIGR02063 1116391000564 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1116391000565 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1116391000566 RNB domain; Region: RNB; pfam00773 1116391000567 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1116391000568 RNA binding site [nucleotide binding]; other site 1116391000569 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1116391000570 SmpB-tmRNA interface; other site 1116391000571 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1116391000572 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1116391000573 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391000574 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391000575 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391000576 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1116391000577 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1116391000578 Helix-turn-helix domain; Region: HTH_18; pfam12833 1116391000579 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391000580 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 1116391000581 putative hydrophobic ligand binding site [chemical binding]; other site 1116391000582 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1116391000583 putative transporter; Provisional; Region: PRK11021 1116391000584 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391000585 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391000586 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391000587 dimerization interface [polypeptide binding]; other site 1116391000588 Imelysin; Region: Peptidase_M75; pfam09375 1116391000589 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1116391000590 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1116391000591 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1116391000592 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1116391000593 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1116391000594 putative active site [active] 1116391000595 catalytic triad [active] 1116391000596 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 1116391000597 putative integrin binding motif; other site 1116391000598 PA/protease domain interface [polypeptide binding]; other site 1116391000599 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1116391000600 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1116391000601 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391000602 Interdomain contacts; other site 1116391000603 GH18 domain of Chitinase D (ChiD). ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins. The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871 1116391000604 Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704 1116391000605 putative active site [active] 1116391000606 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1116391000607 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1116391000608 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391000609 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391000610 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1116391000611 CAT RNA binding domain; Region: CAT_RBD; smart01061 1116391000612 PRD domain; Region: PRD; pfam00874 1116391000613 PRD domain; Region: PRD; pfam00874 1116391000614 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1116391000615 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1116391000616 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1116391000617 active site turn [active] 1116391000618 phosphorylation site [posttranslational modification] 1116391000619 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1116391000620 HPr interaction site; other site 1116391000621 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1116391000622 active site 1116391000623 phosphorylation site [posttranslational modification] 1116391000624 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1116391000625 dimerization domain swap beta strand [polypeptide binding]; other site 1116391000626 regulatory protein interface [polypeptide binding]; other site 1116391000627 active site 1116391000628 regulatory phosphorylation site [posttranslational modification]; other site 1116391000629 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1116391000630 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1116391000631 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1116391000632 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1116391000633 General stress protein [General function prediction only]; Region: GsiB; COG3729 1116391000634 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391000635 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391000636 metal binding site [ion binding]; metal-binding site 1116391000637 active site 1116391000638 I-site; other site 1116391000639 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1116391000640 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 1116391000641 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1116391000642 Hpr binding site; other site 1116391000643 active site 1116391000644 homohexamer subunit interaction site [polypeptide binding]; other site 1116391000645 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1116391000646 extended (e) SDRs; Region: SDR_e; cd08946 1116391000647 NAD(P) binding site [chemical binding]; other site 1116391000648 active site 1116391000649 substrate binding site [chemical binding]; other site 1116391000650 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1116391000651 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1116391000652 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391000653 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391000654 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1116391000655 active site 1116391000656 metal-dependent hydrolase; Provisional; Region: PRK13291 1116391000657 DinB superfamily; Region: DinB_2; pfam12867 1116391000658 short chain dehydrogenase; Provisional; Region: PRK05854 1116391000659 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 1116391000660 putative NAD(P) binding site [chemical binding]; other site 1116391000661 active site 1116391000662 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1116391000663 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1116391000664 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1116391000665 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1116391000666 GIY-YIG motif/motif A; other site 1116391000667 active site 1116391000668 catalytic site [active] 1116391000669 putative DNA binding site [nucleotide binding]; other site 1116391000670 metal binding site [ion binding]; metal-binding site 1116391000671 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1116391000672 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1116391000673 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1116391000674 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1116391000675 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1116391000676 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1116391000677 dinuclear metal binding motif [ion binding]; other site 1116391000678 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391000679 Coenzyme A binding pocket [chemical binding]; other site 1116391000680 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391000681 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391000682 dimerization interface [polypeptide binding]; other site 1116391000683 Histidine kinase; Region: His_kinase; pfam06580 1116391000684 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391000685 ATP binding site [chemical binding]; other site 1116391000686 Mg2+ binding site [ion binding]; other site 1116391000687 G-X-G motif; other site 1116391000688 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1116391000689 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1116391000690 putative ligand binding site [chemical binding]; other site 1116391000691 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391000692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391000693 dimer interface [polypeptide binding]; other site 1116391000694 conserved gate region; other site 1116391000695 ABC-ATPase subunit interface; other site 1116391000696 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391000697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391000698 dimer interface [polypeptide binding]; other site 1116391000699 ABC-ATPase subunit interface; other site 1116391000700 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391000701 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391000702 Fn3 associated; Region: Fn3_assoc; pfam13287 1116391000703 Fn3 associated; Region: Fn3_assoc; pfam13287 1116391000704 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1116391000705 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1116391000706 putative ligand binding site [chemical binding]; other site 1116391000707 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391000708 dimerization interface [polypeptide binding]; other site 1116391000709 putative DNA binding site [nucleotide binding]; other site 1116391000710 putative Zn2+ binding site [ion binding]; other site 1116391000711 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1116391000712 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391000713 Walker A/P-loop; other site 1116391000714 ATP binding site [chemical binding]; other site 1116391000715 Q-loop/lid; other site 1116391000716 ABC transporter signature motif; other site 1116391000717 Walker B; other site 1116391000718 D-loop; other site 1116391000719 H-loop/switch region; other site 1116391000720 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1116391000721 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1116391000722 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391000723 Walker A/P-loop; other site 1116391000724 ATP binding site [chemical binding]; other site 1116391000725 Q-loop/lid; other site 1116391000726 ABC transporter signature motif; other site 1116391000727 Walker B; other site 1116391000728 D-loop; other site 1116391000729 H-loop/switch region; other site 1116391000730 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1116391000731 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1116391000732 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1116391000733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391000734 dimer interface [polypeptide binding]; other site 1116391000735 conserved gate region; other site 1116391000736 putative PBP binding loops; other site 1116391000737 ABC-ATPase subunit interface; other site 1116391000738 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1116391000739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391000740 dimer interface [polypeptide binding]; other site 1116391000741 conserved gate region; other site 1116391000742 putative PBP binding loops; other site 1116391000743 ABC-ATPase subunit interface; other site 1116391000744 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1116391000745 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1116391000746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391000747 S-adenosylmethionine binding site [chemical binding]; other site 1116391000748 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 1116391000749 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1116391000750 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1116391000751 active site 1116391000752 ATP binding site [chemical binding]; other site 1116391000753 substrate binding site [chemical binding]; other site 1116391000754 activation loop (A-loop); other site 1116391000755 S-layer homology domain; Region: SLH; pfam00395 1116391000756 S-layer homology domain; Region: SLH; pfam00395 1116391000757 CAAX protease self-immunity; Region: Abi; pfam02517 1116391000758 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1116391000759 Predicted integral membrane protein [Function unknown]; Region: COG5658 1116391000760 SdpI/YhfL protein family; Region: SdpI; pfam13630 1116391000761 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391000762 putative DNA binding site [nucleotide binding]; other site 1116391000763 putative Zn2+ binding site [ion binding]; other site 1116391000764 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391000765 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391000766 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391000767 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391000768 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391000769 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391000770 active site 1116391000771 catalytic tetrad [active] 1116391000772 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1116391000773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391000774 WHG domain; Region: WHG; pfam13305 1116391000775 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1116391000776 Sulfatase; Region: Sulfatase; pfam00884 1116391000777 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1116391000778 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1116391000779 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1116391000780 active site 1116391000781 P-loop; other site 1116391000782 phosphorylation site [posttranslational modification] 1116391000783 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1116391000784 HTH domain; Region: HTH_11; cl17392 1116391000785 HTH domain; Region: HTH_11; pfam08279 1116391000786 PRD domain; Region: PRD; pfam00874 1116391000787 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1116391000788 active site 1116391000789 P-loop; other site 1116391000790 phosphorylation site [posttranslational modification] 1116391000791 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1116391000792 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1116391000793 active site 1116391000794 phosphorylation site [posttranslational modification] 1116391000795 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1116391000796 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1116391000797 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1116391000798 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 1116391000799 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1116391000800 Zn2+ binding site [ion binding]; other site 1116391000801 Mg2+ binding site [ion binding]; other site 1116391000802 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1116391000803 transglutaminase; Provisional; Region: tgl; PRK03187 1116391000804 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391000805 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1116391000806 active site 1116391000807 metal binding site [ion binding]; metal-binding site 1116391000808 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1116391000809 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391000810 DNA-binding site [nucleotide binding]; DNA binding site 1116391000811 FCD domain; Region: FCD; pfam07729 1116391000812 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1116391000813 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1116391000814 Walker A/P-loop; other site 1116391000815 ATP binding site [chemical binding]; other site 1116391000816 Q-loop/lid; other site 1116391000817 ABC transporter signature motif; other site 1116391000818 Walker B; other site 1116391000819 D-loop; other site 1116391000820 H-loop/switch region; other site 1116391000821 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1116391000822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391000823 putative PBP binding loops; other site 1116391000824 dimer interface [polypeptide binding]; other site 1116391000825 ABC-ATPase subunit interface; other site 1116391000826 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1116391000827 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391000828 membrane-bound complex binding site; other site 1116391000829 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1116391000830 nudix motif; other site 1116391000831 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1116391000832 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391000833 Interdomain contacts; other site 1116391000834 Cytokine receptor motif; other site 1116391000835 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1116391000836 putative metal binding site [ion binding]; other site 1116391000837 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391000838 Interdomain contacts; other site 1116391000839 Cytokine receptor motif; other site 1116391000840 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391000841 Interdomain contacts; other site 1116391000842 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391000843 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391000844 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391000845 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391000846 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391000847 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391000848 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391000849 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391000850 Interdomain contacts; other site 1116391000851 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391000852 Interdomain contacts; other site 1116391000853 Cytokine receptor motif; other site 1116391000854 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1116391000855 catalytic core [active] 1116391000856 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1116391000857 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1116391000858 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1116391000859 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1116391000860 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391000861 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1116391000862 putative active site [active] 1116391000863 heme pocket [chemical binding]; other site 1116391000864 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391000865 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1116391000866 putative active site [active] 1116391000867 heme pocket [chemical binding]; other site 1116391000868 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1116391000869 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391000870 heme pocket [chemical binding]; other site 1116391000871 putative active site [active] 1116391000872 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391000873 putative active site [active] 1116391000874 heme pocket [chemical binding]; other site 1116391000875 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1116391000876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391000877 putative active site [active] 1116391000878 heme pocket [chemical binding]; other site 1116391000879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391000880 dimer interface [polypeptide binding]; other site 1116391000881 phosphorylation site [posttranslational modification] 1116391000882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391000883 ATP binding site [chemical binding]; other site 1116391000884 Mg2+ binding site [ion binding]; other site 1116391000885 G-X-G motif; other site 1116391000886 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1116391000887 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391000888 active site 1116391000889 phosphorylation site [posttranslational modification] 1116391000890 intermolecular recognition site; other site 1116391000891 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1116391000892 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1116391000893 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1116391000894 YhfH-like protein; Region: YhfH; pfam14149 1116391000895 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391000896 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391000897 dimer interface [polypeptide binding]; other site 1116391000898 phosphorylation site [posttranslational modification] 1116391000899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391000900 ATP binding site [chemical binding]; other site 1116391000901 Mg2+ binding site [ion binding]; other site 1116391000902 G-X-G motif; other site 1116391000903 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391000904 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391000905 active site 1116391000906 phosphorylation site [posttranslational modification] 1116391000907 intermolecular recognition site; other site 1116391000908 dimerization interface [polypeptide binding]; other site 1116391000909 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1116391000910 Histidine kinase; Region: HisKA_3; pfam07730 1116391000911 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1116391000912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391000913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391000914 active site 1116391000915 phosphorylation site [posttranslational modification] 1116391000916 intermolecular recognition site; other site 1116391000917 dimerization interface [polypeptide binding]; other site 1116391000918 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391000919 DNA binding residues [nucleotide binding] 1116391000920 dimerization interface [polypeptide binding]; other site 1116391000921 Predicted membrane protein [Function unknown]; Region: COG4818 1116391000922 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391000923 dimer interface [polypeptide binding]; other site 1116391000924 phosphorylation site [posttranslational modification] 1116391000925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391000926 ATP binding site [chemical binding]; other site 1116391000927 Mg2+ binding site [ion binding]; other site 1116391000928 G-X-G motif; other site 1116391000929 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1116391000930 dimer interface [polypeptide binding]; other site 1116391000931 FMN binding site [chemical binding]; other site 1116391000932 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391000933 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391000934 dimerization interface [polypeptide binding]; other site 1116391000935 Histidine kinase; Region: His_kinase; pfam06580 1116391000936 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391000937 ATP binding site [chemical binding]; other site 1116391000938 Mg2+ binding site [ion binding]; other site 1116391000939 G-X-G motif; other site 1116391000940 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391000941 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391000942 active site 1116391000943 phosphorylation site [posttranslational modification] 1116391000944 intermolecular recognition site; other site 1116391000945 dimerization interface [polypeptide binding]; other site 1116391000946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391000947 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391000948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391000949 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1116391000950 EamA-like transporter family; Region: EamA; pfam00892 1116391000951 EamA-like transporter family; Region: EamA; pfam00892 1116391000952 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1116391000953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391000954 putative substrate translocation pore; other site 1116391000955 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391000956 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391000957 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1116391000958 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391000959 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1116391000960 Coenzyme A binding pocket [chemical binding]; other site 1116391000961 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1116391000962 Phage Tail Collar Domain; Region: Collar; pfam07484 1116391000963 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1116391000964 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1116391000965 Phage Tail Collar Domain; Region: Collar; pfam07484 1116391000966 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 1116391000967 Phage Tail Collar Domain; Region: Collar; pfam07484 1116391000968 Domain of unknown function DUF11; Region: DUF11; pfam01345 1116391000969 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1116391000970 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 1116391000971 S-layer homology domain; Region: SLH; pfam00395 1116391000972 S-layer homology domain; Region: SLH; pfam00395 1116391000973 S-layer homology domain; Region: SLH; pfam00395 1116391000974 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391000975 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391000976 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1116391000977 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1116391000978 putative active site [active] 1116391000979 putative FMN binding site [chemical binding]; other site 1116391000980 putative substrate binding site [chemical binding]; other site 1116391000981 putative catalytic residue [active] 1116391000982 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391000983 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1116391000984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391000985 S-adenosylmethionine binding site [chemical binding]; other site 1116391000986 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1116391000987 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391000988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391000989 dimer interface [polypeptide binding]; other site 1116391000990 conserved gate region; other site 1116391000991 putative PBP binding loops; other site 1116391000992 ABC-ATPase subunit interface; other site 1116391000993 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391000994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391000995 dimer interface [polypeptide binding]; other site 1116391000996 conserved gate region; other site 1116391000997 ABC-ATPase subunit interface; other site 1116391000998 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391000999 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391001000 putative alpha-glucosidase; Provisional; Region: PRK10658 1116391001001 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1116391001002 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1116391001003 active site 1116391001004 homotrimer interface [polypeptide binding]; other site 1116391001005 catalytic site [active] 1116391001006 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1116391001007 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391001008 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 1116391001009 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 1116391001010 S-layer homology domain; Region: SLH; pfam00395 1116391001011 S-layer homology domain; Region: SLH; pfam00395 1116391001012 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 1116391001013 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1116391001014 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1116391001015 metal ion-dependent adhesion site (MIDAS); other site 1116391001016 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1116391001017 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1116391001018 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1116391001019 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1116391001020 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1116391001021 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1116391001022 active site 1116391001023 substrate binding site [chemical binding]; other site 1116391001024 ATP binding site [chemical binding]; other site 1116391001025 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 1116391001026 AAA domain; Region: AAA_31; pfam13614 1116391001027 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1116391001028 Protein of unknown function (DUF1162); Region: DUF1162; pfam06650 1116391001029 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1116391001030 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1116391001031 Walker A motif; other site 1116391001032 ATP binding site [chemical binding]; other site 1116391001033 Walker B motif; other site 1116391001034 S-layer homology domain; Region: SLH; pfam00395 1116391001035 S-layer homology domain; Region: SLH; pfam00395 1116391001036 putative catalytic domain of glycoside hydrolase family 119 (GH119); Region: GH119_BcIgtZ-like; cd11663 1116391001037 putative active site [active] 1116391001038 catalytic site [active] 1116391001039 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391001040 Interdomain contacts; other site 1116391001041 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 1116391001042 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065 1116391001043 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 1116391001044 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1116391001045 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1116391001046 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1116391001047 DctM-like transporters; Region: DctM; pfam06808 1116391001048 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1116391001049 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1116391001050 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1116391001051 Cache domain; Region: Cache_1; pfam02743 1116391001052 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391001053 dimerization interface [polypeptide binding]; other site 1116391001054 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391001055 Histidine kinase; Region: His_kinase; pfam06580 1116391001056 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391001057 ATP binding site [chemical binding]; other site 1116391001058 Mg2+ binding site [ion binding]; other site 1116391001059 G-X-G motif; other site 1116391001060 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391001061 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391001062 active site 1116391001063 phosphorylation site [posttranslational modification] 1116391001064 intermolecular recognition site; other site 1116391001065 dimerization interface [polypeptide binding]; other site 1116391001066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391001067 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391001068 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391001069 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1116391001070 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391001071 active site 1116391001072 phosphorylation site [posttranslational modification] 1116391001073 intermolecular recognition site; other site 1116391001074 dimerization interface [polypeptide binding]; other site 1116391001075 B12 binding domain; Region: B12-binding_2; pfam02607 1116391001076 B12 binding domain; Region: B12-binding; pfam02310 1116391001077 B12 binding site [chemical binding]; other site 1116391001078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391001079 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391001080 dimer interface [polypeptide binding]; other site 1116391001081 phosphorylation site [posttranslational modification] 1116391001082 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391001083 ATP binding site [chemical binding]; other site 1116391001084 Mg2+ binding site [ion binding]; other site 1116391001085 G-X-G motif; other site 1116391001086 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391001087 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391001088 active site 1116391001089 phosphorylation site [posttranslational modification] 1116391001090 intermolecular recognition site; other site 1116391001091 dimerization interface [polypeptide binding]; other site 1116391001092 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1116391001093 putative binding surface; other site 1116391001094 active site 1116391001095 Pectate lyase; Region: Pectate_lyase; pfam03211 1116391001096 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1116391001097 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1116391001098 Pectate lyase; Region: Pec_lyase_C; cl01593 1116391001099 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 1116391001100 Protein of unknown function; Region: DUF3658; pfam12395 1116391001101 Leucine rich repeat; Region: LRR_8; pfam13855 1116391001102 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1116391001103 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391001104 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391001105 DNA binding residues [nucleotide binding] 1116391001106 SnoaL-like domain; Region: SnoaL_2; pfam12680 1116391001107 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1116391001108 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1116391001109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391001110 Coenzyme A binding pocket [chemical binding]; other site 1116391001111 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1116391001112 dimer interface [polypeptide binding]; other site 1116391001113 FMN binding site [chemical binding]; other site 1116391001114 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1116391001115 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1116391001116 P-loop; other site 1116391001117 Magnesium ion binding site [ion binding]; other site 1116391001118 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1116391001119 Magnesium ion binding site [ion binding]; other site 1116391001120 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1116391001121 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1116391001122 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 1116391001123 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 1116391001124 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 1116391001125 active site 1116391001126 RNA/DNA hybrid binding site [nucleotide binding]; other site 1116391001127 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1116391001128 putative hydrolase; Provisional; Region: PRK11460 1116391001129 Predicted esterase [General function prediction only]; Region: COG0400 1116391001130 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1116391001131 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391001132 Zn binding site [ion binding]; other site 1116391001133 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1116391001134 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391001135 Zn binding site [ion binding]; other site 1116391001136 DoxX; Region: DoxX; pfam07681 1116391001137 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391001138 MarR family; Region: MarR; pfam01047 1116391001139 MarR family; Region: MarR_2; cl17246 1116391001140 Predicted transcriptional regulator [Transcription]; Region: COG2378 1116391001141 HTH domain; Region: HTH_11; pfam08279 1116391001142 WYL domain; Region: WYL; pfam13280 1116391001143 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1116391001144 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1116391001145 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1116391001146 Na2 binding site [ion binding]; other site 1116391001147 putative substrate binding site 1 [chemical binding]; other site 1116391001148 Na binding site 1 [ion binding]; other site 1116391001149 putative substrate binding site 2 [chemical binding]; other site 1116391001150 PAS fold; Region: PAS_4; pfam08448 1116391001151 PAS domain S-box; Region: sensory_box; TIGR00229 1116391001152 PAS domain; Region: PAS; smart00091 1116391001153 putative active site [active] 1116391001154 heme pocket [chemical binding]; other site 1116391001155 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391001156 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391001157 metal binding site [ion binding]; metal-binding site 1116391001158 active site 1116391001159 I-site; other site 1116391001160 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1116391001161 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1116391001162 ThiC-associated domain; Region: ThiC-associated; pfam13667 1116391001163 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1116391001164 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 1116391001165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391001166 Walker A/P-loop; other site 1116391001167 ATP binding site [chemical binding]; other site 1116391001168 Q-loop/lid; other site 1116391001169 ABC transporter signature motif; other site 1116391001170 Walker B; other site 1116391001171 D-loop; other site 1116391001172 H-loop/switch region; other site 1116391001173 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1116391001174 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391001175 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391001176 dimerization interface [polypeptide binding]; other site 1116391001177 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391001178 dimer interface [polypeptide binding]; other site 1116391001179 phosphorylation site [posttranslational modification] 1116391001180 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391001181 ATP binding site [chemical binding]; other site 1116391001182 Mg2+ binding site [ion binding]; other site 1116391001183 G-X-G motif; other site 1116391001184 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391001185 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391001186 active site 1116391001187 phosphorylation site [posttranslational modification] 1116391001188 intermolecular recognition site; other site 1116391001189 dimerization interface [polypeptide binding]; other site 1116391001190 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391001191 DNA binding site [nucleotide binding] 1116391001192 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391001193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391001194 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1116391001195 pyruvate kinase; Provisional; Region: PRK05826 1116391001196 domain interfaces; other site 1116391001197 active site 1116391001198 Protein of unknown function (DUF554); Region: DUF554; pfam04474 1116391001199 seryl-tRNA synthetase; Provisional; Region: PRK05431 1116391001200 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1116391001201 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1116391001202 motif 1; other site 1116391001203 dimer interface [polypeptide binding]; other site 1116391001204 active site 1116391001205 motif 2; other site 1116391001206 motif 3; other site 1116391001207 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391001208 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1116391001209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391001210 Walker A/P-loop; other site 1116391001211 ATP binding site [chemical binding]; other site 1116391001212 Q-loop/lid; other site 1116391001213 ABC transporter signature motif; other site 1116391001214 Walker B; other site 1116391001215 D-loop; other site 1116391001216 H-loop/switch region; other site 1116391001217 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391001218 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391001219 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1116391001220 Walker A/P-loop; other site 1116391001221 ATP binding site [chemical binding]; other site 1116391001222 Q-loop/lid; other site 1116391001223 ABC transporter signature motif; other site 1116391001224 Walker B; other site 1116391001225 D-loop; other site 1116391001226 H-loop/switch region; other site 1116391001227 Thiamine pyrophosphokinase; Region: TPK; cd07995 1116391001228 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 1116391001229 active site 1116391001230 dimerization interface [polypeptide binding]; other site 1116391001231 thiamine binding site [chemical binding]; other site 1116391001232 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1116391001233 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1116391001234 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1116391001235 Virulence factor; Region: Virulence_fact; pfam13769 1116391001236 HEAT repeats; Region: HEAT_2; pfam13646 1116391001237 HEAT repeat; Region: HEAT; pfam02985 1116391001238 HEAT repeats; Region: HEAT_2; pfam13646 1116391001239 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1116391001240 DinB superfamily; Region: DinB_2; pfam12867 1116391001241 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1116391001242 Guanylate kinase; Region: Guanylate_kin; pfam00625 1116391001243 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1116391001244 active site 1116391001245 helicase 45; Provisional; Region: PTZ00424 1116391001246 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1116391001247 ATP binding site [chemical binding]; other site 1116391001248 Mg++ binding site [ion binding]; other site 1116391001249 motif III; other site 1116391001250 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1116391001251 nucleotide binding region [chemical binding]; other site 1116391001252 ATP-binding site [chemical binding]; other site 1116391001253 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1116391001254 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1116391001255 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1116391001256 Cytochrome c; Region: Cytochrom_C; cl11414 1116391001257 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1116391001258 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1116391001259 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1116391001260 D-pathway; other site 1116391001261 Putative ubiquinol binding site [chemical binding]; other site 1116391001262 Low-spin heme (heme b) binding site [chemical binding]; other site 1116391001263 Putative water exit pathway; other site 1116391001264 Binuclear center (heme o3/CuB) [ion binding]; other site 1116391001265 K-pathway; other site 1116391001266 Putative proton exit pathway; other site 1116391001267 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1116391001268 Subunit I/III interface [polypeptide binding]; other site 1116391001269 Subunit III/IV interface [polypeptide binding]; other site 1116391001270 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1116391001271 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 1116391001272 Protein of unknown function (DUF420); Region: DUF420; pfam04238 1116391001273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391001274 Bacterial SH3 domain; Region: SH3_3; pfam08239 1116391001275 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1116391001276 NlpC/P60 family; Region: NLPC_P60; pfam00877 1116391001277 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1116391001278 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1116391001279 catalytic residues [active] 1116391001280 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1116391001281 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1116391001282 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1116391001283 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1116391001284 putative NAD(P) binding site [chemical binding]; other site 1116391001285 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391001286 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391001287 dimerization interface [polypeptide binding]; other site 1116391001288 putative DNA binding site [nucleotide binding]; other site 1116391001289 putative Zn2+ binding site [ion binding]; other site 1116391001290 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1116391001291 MOSC domain; Region: MOSC; pfam03473 1116391001292 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 1116391001293 active site 1116391001294 catalytic residues [active] 1116391001295 metal binding site [ion binding]; metal-binding site 1116391001296 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1116391001297 putative active site [active] 1116391001298 nucleotide binding site [chemical binding]; other site 1116391001299 nudix motif; other site 1116391001300 putative metal binding site [ion binding]; other site 1116391001301 S-layer homology domain; Region: SLH; pfam00395 1116391001302 S-layer homology domain; Region: SLH; pfam00395 1116391001303 S-layer homology domain; Region: SLH; pfam00395 1116391001304 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1116391001305 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1116391001306 S-layer homology domain; Region: SLH; pfam00395 1116391001307 S-layer homology domain; Region: SLH; pfam00395 1116391001308 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1116391001309 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1116391001310 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1116391001311 putative acyl-acceptor binding pocket; other site 1116391001312 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1116391001313 acyl-activating enzyme (AAE) consensus motif; other site 1116391001314 AMP binding site [chemical binding]; other site 1116391001315 active site 1116391001316 CoA binding site [chemical binding]; other site 1116391001317 HI0933-like protein; Region: HI0933_like; pfam03486 1116391001318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1116391001319 Site-specific recombinase; Region: SpecificRecomb; cl15411 1116391001320 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1116391001321 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1116391001322 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391001323 dimerization interface [polypeptide binding]; other site 1116391001324 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391001325 dimer interface [polypeptide binding]; other site 1116391001326 putative CheW interface [polypeptide binding]; other site 1116391001327 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1116391001328 Domain of unknown function DUF21; Region: DUF21; pfam01595 1116391001329 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1116391001330 Transporter associated domain; Region: CorC_HlyC; smart01091 1116391001331 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1116391001332 Cation efflux family; Region: Cation_efflux; pfam01545 1116391001333 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 1116391001334 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 1116391001335 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1116391001336 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1116391001337 homodimer interface [polypeptide binding]; other site 1116391001338 NAD binding pocket [chemical binding]; other site 1116391001339 ATP binding pocket [chemical binding]; other site 1116391001340 Mg binding site [ion binding]; other site 1116391001341 active-site loop [active] 1116391001342 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1116391001343 dimanganese center [ion binding]; other site 1116391001344 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1116391001345 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1116391001346 inhibitor-cofactor binding pocket; inhibition site 1116391001347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391001348 catalytic residue [active] 1116391001349 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1116391001350 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1116391001351 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391001352 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391001353 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391001354 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391001355 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1116391001356 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1116391001357 minor groove reading motif; other site 1116391001358 helix-hairpin-helix signature motif; other site 1116391001359 substrate binding pocket [chemical binding]; other site 1116391001360 active site 1116391001361 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1116391001362 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1116391001363 DNA binding and oxoG recognition site [nucleotide binding] 1116391001364 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1116391001365 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1116391001366 ligand binding site [chemical binding]; other site 1116391001367 flexible hinge region; other site 1116391001368 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1116391001369 non-specific DNA interactions [nucleotide binding]; other site 1116391001370 DNA binding site [nucleotide binding] 1116391001371 sequence specific DNA binding site [nucleotide binding]; other site 1116391001372 putative cAMP binding site [chemical binding]; other site 1116391001373 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1116391001374 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1116391001375 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1116391001376 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1116391001377 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1116391001378 active site 1116391001379 catalytic residues [active] 1116391001380 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1116391001381 S-layer homology domain; Region: SLH; pfam00395 1116391001382 S-layer homology domain; Region: SLH; pfam00395 1116391001383 putative acetyltransferase; Provisional; Region: PRK03624 1116391001384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391001385 Coenzyme A binding pocket [chemical binding]; other site 1116391001386 Protein of unknown function (DUF402); Region: DUF402; cl00979 1116391001387 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1116391001388 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1116391001389 Catalytic site [active] 1116391001390 epoxyqueuosine reductase; Region: TIGR00276 1116391001391 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1116391001392 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 1116391001393 protein binding surface [polypeptide binding]; other site 1116391001394 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1116391001395 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1116391001396 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1116391001397 DNA binding site [nucleotide binding] 1116391001398 active site 1116391001399 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1116391001400 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1116391001401 Zn2+ binding site [ion binding]; other site 1116391001402 Mg2+ binding site [ion binding]; other site 1116391001403 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1116391001404 homodecamer interface [polypeptide binding]; other site 1116391001405 GTP cyclohydrolase I; Provisional; Region: PLN03044 1116391001406 active site 1116391001407 putative catalytic site residues [active] 1116391001408 zinc binding site [ion binding]; other site 1116391001409 GTP-CH-I/GFRP interaction surface; other site 1116391001410 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1116391001411 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1116391001412 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1116391001413 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1116391001414 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1116391001415 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1116391001416 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1116391001417 Bacterial transcriptional regulator; Region: IclR; pfam01614 1116391001418 Putative amidase domain; Region: Amidase_6; pfam12671 1116391001419 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1116391001420 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1116391001421 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1116391001422 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391001423 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391001424 Transposase; Region: HTH_Tnp_1; cl17663 1116391001425 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391001426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391001427 HTH-like domain; Region: HTH_21; pfam13276 1116391001428 Integrase core domain; Region: rve; pfam00665 1116391001429 Integrase core domain; Region: rve_2; pfam13333 1116391001430 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1116391001431 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 1116391001432 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1116391001433 NAD binding site [chemical binding]; other site 1116391001434 homotetramer interface [polypeptide binding]; other site 1116391001435 homodimer interface [polypeptide binding]; other site 1116391001436 substrate binding site [chemical binding]; other site 1116391001437 active site 1116391001438 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1116391001439 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1116391001440 active site 1116391001441 dimerization interface [polypeptide binding]; other site 1116391001442 AAA domain; Region: AAA_26; pfam13500 1116391001443 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1116391001444 ADP binding site [chemical binding]; other site 1116391001445 biotin synthase; Validated; Region: PRK06256 1116391001446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391001447 FeS/SAM binding site; other site 1116391001448 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1116391001449 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1116391001450 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1116391001451 substrate-cofactor binding pocket; other site 1116391001452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391001453 catalytic residue [active] 1116391001454 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1116391001455 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1116391001456 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391001457 S-adenosylmethionine binding site [chemical binding]; other site 1116391001458 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK12481 1116391001459 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1116391001460 NADP binding site [chemical binding]; other site 1116391001461 homodimer interface [polypeptide binding]; other site 1116391001462 active site 1116391001463 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1116391001464 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1116391001465 substrate binding site [chemical binding]; other site 1116391001466 ATP binding site [chemical binding]; other site 1116391001467 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1116391001468 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1116391001469 active site 1116391001470 intersubunit interface [polypeptide binding]; other site 1116391001471 catalytic residue [active] 1116391001472 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1116391001473 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1116391001474 [2Fe-2S] cluster binding site [ion binding]; other site 1116391001475 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1116391001476 hydrophobic ligand binding site; other site 1116391001477 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 1116391001478 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1116391001479 active site 1116391001480 dimer interface [polypeptide binding]; other site 1116391001481 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1116391001482 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1116391001483 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 1116391001484 active site 1116391001485 FMN binding site [chemical binding]; other site 1116391001486 substrate binding site [chemical binding]; other site 1116391001487 3Fe-4S cluster binding site [ion binding]; other site 1116391001488 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 1116391001489 domain_subunit interface; other site 1116391001490 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1116391001491 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1116391001492 inhibitor-cofactor binding pocket; inhibition site 1116391001493 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391001494 catalytic residue [active] 1116391001495 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1116391001496 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1116391001497 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1116391001498 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 1116391001499 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1116391001500 Walker A/P-loop; other site 1116391001501 ATP binding site [chemical binding]; other site 1116391001502 Q-loop/lid; other site 1116391001503 ABC transporter signature motif; other site 1116391001504 Walker B; other site 1116391001505 D-loop; other site 1116391001506 H-loop/switch region; other site 1116391001507 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1116391001508 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1116391001509 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1116391001510 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391001511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391001512 active site 1116391001513 phosphorylation site [posttranslational modification] 1116391001514 intermolecular recognition site; other site 1116391001515 dimerization interface [polypeptide binding]; other site 1116391001516 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391001517 DNA binding residues [nucleotide binding] 1116391001518 dimerization interface [polypeptide binding]; other site 1116391001519 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1116391001520 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1116391001521 catalytic triad [active] 1116391001522 glycerate dehydrogenase; Provisional; Region: PRK06487 1116391001523 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1116391001524 putative ligand binding site [chemical binding]; other site 1116391001525 putative NAD binding site [chemical binding]; other site 1116391001526 catalytic site [active] 1116391001527 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1116391001528 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1116391001529 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1116391001530 NodB motif; other site 1116391001531 active site 1116391001532 catalytic site [active] 1116391001533 Zn binding site [ion binding]; other site 1116391001534 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391001535 MoxR-like ATPases [General function prediction only]; Region: COG0714 1116391001536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391001537 Walker A motif; other site 1116391001538 ATP binding site [chemical binding]; other site 1116391001539 Walker B motif; other site 1116391001540 arginine finger; other site 1116391001541 Protein of unknown function DUF58; Region: DUF58; pfam01882 1116391001542 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1116391001543 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1116391001544 GMP synthase; Reviewed; Region: guaA; PRK00074 1116391001545 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1116391001546 AMP/PPi binding site [chemical binding]; other site 1116391001547 candidate oxyanion hole; other site 1116391001548 catalytic triad [active] 1116391001549 potential glutamine specificity residues [chemical binding]; other site 1116391001550 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1116391001551 ATP Binding subdomain [chemical binding]; other site 1116391001552 Ligand Binding sites [chemical binding]; other site 1116391001553 Dimerization subdomain; other site 1116391001554 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1116391001555 2-isopropylmalate synthase; Validated; Region: PRK00915 1116391001556 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1116391001557 active site 1116391001558 catalytic residues [active] 1116391001559 metal binding site [ion binding]; metal-binding site 1116391001560 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1116391001561 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1116391001562 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1116391001563 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391001564 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391001565 ABC transporter; Region: ABC_tran_2; pfam12848 1116391001566 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391001567 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 1116391001568 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1116391001569 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1116391001570 trimer interface [polypeptide binding]; other site 1116391001571 dimer interface [polypeptide binding]; other site 1116391001572 putative active site [active] 1116391001573 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1116391001574 MPT binding site; other site 1116391001575 trimer interface [polypeptide binding]; other site 1116391001576 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 1116391001577 putative MPT binding site; other site 1116391001578 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1116391001579 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1116391001580 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1116391001581 oligomerisation interface [polypeptide binding]; other site 1116391001582 mobile loop; other site 1116391001583 roof hairpin; other site 1116391001584 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1116391001585 hinge regions; other site 1116391001586 stacking interactions; other site 1116391001587 SNF2 Helicase protein; Region: DUF3670; pfam12419 1116391001588 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1116391001589 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1116391001590 ATP binding site [chemical binding]; other site 1116391001591 putative Mg++ binding site [ion binding]; other site 1116391001592 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1116391001593 nucleotide binding region [chemical binding]; other site 1116391001594 ATP-binding site [chemical binding]; other site 1116391001595 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 1116391001596 S-layer homology domain; Region: SLH; pfam00395 1116391001597 S-layer homology domain; Region: SLH; pfam00395 1116391001598 S-layer homology domain; Region: SLH; pfam00395 1116391001599 S-layer homology domain; Region: SLH; pfam00395 1116391001600 S-layer homology domain; Region: SLH; pfam00395 1116391001601 S-layer homology domain; Region: SLH; pfam00395 1116391001602 poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939 1116391001603 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1116391001604 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1116391001605 substrate binding site; other site 1116391001606 tetramer interface; other site 1116391001607 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1116391001608 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1116391001609 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1116391001610 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1116391001611 Walker A/P-loop; other site 1116391001612 ATP binding site [chemical binding]; other site 1116391001613 Q-loop/lid; other site 1116391001614 ABC transporter signature motif; other site 1116391001615 Walker B; other site 1116391001616 D-loop; other site 1116391001617 H-loop/switch region; other site 1116391001618 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1116391001619 putative carbohydrate binding site [chemical binding]; other site 1116391001620 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1116391001621 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391001622 S-adenosylmethionine binding site [chemical binding]; other site 1116391001623 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391001624 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1116391001625 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1116391001626 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1116391001627 active site 1116391001628 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391001629 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1116391001630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391001631 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1116391001632 NAD(P) binding site [chemical binding]; other site 1116391001633 active site 1116391001634 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1116391001635 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1116391001636 Probable Catalytic site; other site 1116391001637 metal-binding site 1116391001638 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1116391001639 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1116391001640 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1116391001641 NAD binding site [chemical binding]; other site 1116391001642 substrate binding site [chemical binding]; other site 1116391001643 homodimer interface [polypeptide binding]; other site 1116391001644 active site 1116391001645 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1116391001646 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1116391001647 NADP binding site [chemical binding]; other site 1116391001648 active site 1116391001649 putative substrate binding site [chemical binding]; other site 1116391001650 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1116391001651 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1116391001652 Probable Catalytic site; other site 1116391001653 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1116391001654 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1116391001655 Probable Catalytic site; other site 1116391001656 metal-binding site 1116391001657 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1116391001658 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391001659 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1116391001660 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1116391001661 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1116391001662 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1116391001663 Ligand binding site; other site 1116391001664 Putative Catalytic site; other site 1116391001665 DXD motif; other site 1116391001666 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1116391001667 Domain of unknown function (DUF4367); Region: DUF4367; pfam14285 1116391001668 alanine racemase; Reviewed; Region: alr; PRK00053 1116391001669 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1116391001670 active site 1116391001671 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1116391001672 dimer interface [polypeptide binding]; other site 1116391001673 substrate binding site [chemical binding]; other site 1116391001674 catalytic residues [active] 1116391001675 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 1116391001676 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 1116391001677 PemK-like protein; Region: PemK; pfam02452 1116391001678 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1116391001679 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1116391001680 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1116391001681 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1116391001682 RNA binding site [nucleotide binding]; other site 1116391001683 SprT homologues; Region: SprT; cl01182 1116391001684 SprT-like family; Region: SprT-like; pfam10263 1116391001685 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 1116391001686 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1116391001687 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1116391001688 dimanganese center [ion binding]; other site 1116391001689 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1116391001690 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1116391001691 active site 1116391001692 catalytic site [active] 1116391001693 metal binding site [ion binding]; metal-binding site 1116391001694 dimer interface [polypeptide binding]; other site 1116391001695 S-layer homology domain; Region: SLH; pfam00395 1116391001696 S-layer homology domain; Region: SLH; pfam00395 1116391001697 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 1116391001698 endonuclease IV; Provisional; Region: PRK01060 1116391001699 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1116391001700 AP (apurinic/apyrimidinic) site pocket; other site 1116391001701 DNA interaction; other site 1116391001702 Metal-binding active site; metal-binding site 1116391001703 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1116391001704 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1116391001705 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1116391001706 putative active site [active] 1116391001707 putative substrate binding site [chemical binding]; other site 1116391001708 putative cosubstrate binding site; other site 1116391001709 catalytic site [active] 1116391001710 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1116391001711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1116391001712 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1116391001713 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1116391001714 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1116391001715 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1116391001716 [2Fe-2S] cluster binding site [ion binding]; other site 1116391001717 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1116391001718 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1116391001719 TPP-binding site [chemical binding]; other site 1116391001720 dimer interface [polypeptide binding]; other site 1116391001721 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1116391001722 PYR/PP interface [polypeptide binding]; other site 1116391001723 dimer interface [polypeptide binding]; other site 1116391001724 TPP binding site [chemical binding]; other site 1116391001725 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1116391001726 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1116391001727 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1116391001728 PilZ domain; Region: PilZ; pfam07238 1116391001729 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1116391001730 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1116391001731 active site 1116391001732 dimer interface [polypeptide binding]; other site 1116391001733 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1116391001734 dimer interface [polypeptide binding]; other site 1116391001735 active site 1116391001736 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1116391001737 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1116391001738 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1116391001739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391001740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391001741 WHG domain; Region: WHG; pfam13305 1116391001742 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1116391001743 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 1116391001744 Ribosomal protein L35Ae; Region: Ribosomal_L35Ae; cl01033 1116391001745 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1116391001746 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1116391001747 Helix-turn-helix domain; Region: HTH_17; pfam12728 1116391001748 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1116391001749 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1116391001750 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1116391001751 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 1116391001752 active site 1116391001753 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1116391001754 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1116391001755 putative sugar binding sites [chemical binding]; other site 1116391001756 Q-X-W motif; other site 1116391001757 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1116391001758 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391001759 active site 1116391001760 phosphorylation site [posttranslational modification] 1116391001761 intermolecular recognition site; other site 1116391001762 LytTr DNA-binding domain; Region: LytTR; smart00850 1116391001763 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391001764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391001765 active site 1116391001766 phosphorylation site [posttranslational modification] 1116391001767 intermolecular recognition site; other site 1116391001768 dimerization interface [polypeptide binding]; other site 1116391001769 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391001770 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1116391001771 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1116391001772 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1116391001773 GAF domain; Region: GAF_3; pfam13492 1116391001774 GAF domain; Region: GAF_2; pfam13185 1116391001775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391001776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391001777 dimer interface [polypeptide binding]; other site 1116391001778 phosphorylation site [posttranslational modification] 1116391001779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391001780 ATP binding site [chemical binding]; other site 1116391001781 Mg2+ binding site [ion binding]; other site 1116391001782 G-X-G motif; other site 1116391001783 alpha-galactosidase; Provisional; Region: PRK15076 1116391001784 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1116391001785 NAD binding site [chemical binding]; other site 1116391001786 sugar binding site [chemical binding]; other site 1116391001787 divalent metal binding site [ion binding]; other site 1116391001788 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1116391001789 dimer interface [polypeptide binding]; other site 1116391001790 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1116391001791 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1116391001792 SelR domain; Region: SelR; pfam01641 1116391001793 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 1116391001794 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1116391001795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391001796 Coenzyme A binding pocket [chemical binding]; other site 1116391001797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391001798 dimerization interface [polypeptide binding]; other site 1116391001799 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391001800 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391001801 metal binding site [ion binding]; metal-binding site 1116391001802 active site 1116391001803 I-site; other site 1116391001804 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1116391001805 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1116391001806 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1116391001807 nudix motif; other site 1116391001808 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1116391001809 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1116391001810 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1116391001811 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1116391001812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391001813 putative substrate translocation pore; other site 1116391001814 Uncharacterized conserved protein [Function unknown]; Region: COG3339 1116391001815 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1116391001816 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1116391001817 conserved cys residue [active] 1116391001818 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1116391001819 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1116391001820 metal binding site [ion binding]; metal-binding site 1116391001821 active site 1116391001822 Sulfatase; Region: Sulfatase; cl17466 1116391001823 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1116391001824 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1116391001825 RNA binding surface [nucleotide binding]; other site 1116391001826 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1116391001827 active site 1116391001828 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1116391001829 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1116391001830 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1116391001831 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1116391001832 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 1116391001833 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1116391001834 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391001835 FeS/SAM binding site; other site 1116391001836 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 1116391001837 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1116391001838 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1116391001839 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391001840 S-adenosylmethionine binding site [chemical binding]; other site 1116391001841 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1116391001842 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391001843 FeS/SAM binding site; other site 1116391001844 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1116391001845 monogalactosyldiacylglycerol synthase; Region: PLN02605 1116391001846 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1116391001847 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1116391001848 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1116391001849 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1116391001850 active site 1116391001851 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391001852 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1116391001853 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1116391001854 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1116391001855 DXD motif; other site 1116391001856 translation initiation factor IF-3; Region: infC; TIGR00168 1116391001857 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1116391001858 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1116391001859 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1116391001860 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1116391001861 23S rRNA binding site [nucleotide binding]; other site 1116391001862 L21 binding site [polypeptide binding]; other site 1116391001863 L13 binding site [polypeptide binding]; other site 1116391001864 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1116391001865 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391001866 active site 1116391001867 metal binding site [ion binding]; metal-binding site 1116391001868 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 1116391001869 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391001870 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1116391001871 active site 1116391001872 metal binding site [ion binding]; metal-binding site 1116391001873 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 1116391001874 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 1116391001875 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1116391001876 PYR/PP interface [polypeptide binding]; other site 1116391001877 dimer interface [polypeptide binding]; other site 1116391001878 TPP binding site [chemical binding]; other site 1116391001879 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1116391001880 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1116391001881 TPP-binding site [chemical binding]; other site 1116391001882 dimer interface [polypeptide binding]; other site 1116391001883 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1116391001884 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1116391001885 putative valine binding site [chemical binding]; other site 1116391001886 dimer interface [polypeptide binding]; other site 1116391001887 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1116391001888 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1116391001889 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1116391001890 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1116391001891 2-isopropylmalate synthase; Validated; Region: PRK00915 1116391001892 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1116391001893 active site 1116391001894 catalytic residues [active] 1116391001895 metal binding site [ion binding]; metal-binding site 1116391001896 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1116391001897 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1116391001898 active site 1116391001899 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1116391001900 HAMP domain; Region: HAMP; pfam00672 1116391001901 dimerization interface [polypeptide binding]; other site 1116391001902 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391001903 dimer interface [polypeptide binding]; other site 1116391001904 putative CheW interface [polypeptide binding]; other site 1116391001905 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391001906 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1116391001907 acyl-activating enzyme (AAE) consensus motif; other site 1116391001908 AMP binding site [chemical binding]; other site 1116391001909 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391001910 thioester reductase domain; Region: Thioester-redct; TIGR01746 1116391001911 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1116391001912 putative NAD(P) binding site [chemical binding]; other site 1116391001913 active site 1116391001914 putative substrate binding site [chemical binding]; other site 1116391001915 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1116391001916 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1116391001917 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391001918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391001919 homodimer interface [polypeptide binding]; other site 1116391001920 catalytic residue [active] 1116391001921 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1116391001922 tartrate dehydrogenase; Region: TTC; TIGR02089 1116391001923 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1116391001924 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1116391001925 dimer interface [polypeptide binding]; other site 1116391001926 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1116391001927 catalytic triad [active] 1116391001928 peroxidatic and resolving cysteines [active] 1116391001929 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1116391001930 lipoyl attachment site [posttranslational modification]; other site 1116391001931 KTSC domain; Region: KTSC; pfam13619 1116391001932 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1116391001933 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 1116391001934 active site 1116391001935 Substrate binding site; other site 1116391001936 Mg++ binding site; other site 1116391001937 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1116391001938 putative trimer interface [polypeptide binding]; other site 1116391001939 putative CoA binding site [chemical binding]; other site 1116391001940 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1116391001941 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1116391001942 active site 1116391001943 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1116391001944 substrate binding site [chemical binding]; other site 1116391001945 metal binding site [ion binding]; metal-binding site 1116391001946 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1116391001947 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 1116391001948 active site 1116391001949 substrate binding site [chemical binding]; other site 1116391001950 catalytic site [active] 1116391001951 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1116391001952 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391001953 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1116391001954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 1116391001955 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 1116391001956 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391001957 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 1116391001958 DinB superfamily; Region: DinB_2; pfam12867 1116391001959 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1116391001960 CGNR zinc finger; Region: zf-CGNR; pfam11706 1116391001961 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1116391001962 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391001963 active site 1116391001964 catalytic tetrad [active] 1116391001965 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1116391001966 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391001967 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391001968 PAS domain S-box; Region: sensory_box; TIGR00229 1116391001969 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391001970 putative active site [active] 1116391001971 heme pocket [chemical binding]; other site 1116391001972 PAS fold; Region: PAS_3; pfam08447 1116391001973 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1116391001974 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1116391001975 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391001976 putative active site [active] 1116391001977 heme pocket [chemical binding]; other site 1116391001978 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391001979 dimer interface [polypeptide binding]; other site 1116391001980 phosphorylation site [posttranslational modification] 1116391001981 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391001982 ATP binding site [chemical binding]; other site 1116391001983 Mg2+ binding site [ion binding]; other site 1116391001984 G-X-G motif; other site 1116391001985 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1116391001986 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1116391001987 Moco binding site; other site 1116391001988 metal coordination site [ion binding]; other site 1116391001989 Predicted transcriptional regulator [Transcription]; Region: COG2378 1116391001990 HTH domain; Region: HTH_11; pfam08279 1116391001991 WYL domain; Region: WYL; pfam13280 1116391001992 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1116391001993 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1116391001994 conserved cys residue [active] 1116391001995 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1116391001996 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1116391001997 Predicted transcriptional regulators [Transcription]; Region: COG1695 1116391001998 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1116391001999 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1116391002000 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391002001 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391002002 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391002003 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391002004 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1116391002005 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391002006 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391002007 dimer interface [polypeptide binding]; other site 1116391002008 putative CheW interface [polypeptide binding]; other site 1116391002009 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1116391002010 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1116391002011 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 1116391002012 ligand binding site [chemical binding]; other site 1116391002013 flexible hinge region; other site 1116391002014 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1116391002015 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1116391002016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391002017 Coenzyme A binding pocket [chemical binding]; other site 1116391002018 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391002019 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391002020 dimer interface [polypeptide binding]; other site 1116391002021 phosphorylation site [posttranslational modification] 1116391002022 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391002023 ATP binding site [chemical binding]; other site 1116391002024 Mg2+ binding site [ion binding]; other site 1116391002025 G-X-G motif; other site 1116391002026 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391002027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391002028 active site 1116391002029 phosphorylation site [posttranslational modification] 1116391002030 intermolecular recognition site; other site 1116391002031 dimerization interface [polypeptide binding]; other site 1116391002032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391002033 DNA binding site [nucleotide binding] 1116391002034 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1116391002035 putative metal binding residues [ion binding]; other site 1116391002036 signature motif; other site 1116391002037 dimer interface [polypeptide binding]; other site 1116391002038 active site 1116391002039 polyP binding site; other site 1116391002040 substrate binding site [chemical binding]; other site 1116391002041 acceptor-phosphate pocket; other site 1116391002042 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1116391002043 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1116391002044 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1116391002045 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391002046 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1116391002047 active site 1116391002048 oxyanion hole [active] 1116391002049 catalytic triad [active] 1116391002050 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1116391002051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391002052 putative substrate translocation pore; other site 1116391002053 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391002054 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391002055 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391002056 active site 1116391002057 phosphorylation site [posttranslational modification] 1116391002058 intermolecular recognition site; other site 1116391002059 dimerization interface [polypeptide binding]; other site 1116391002060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391002061 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391002062 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391002063 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391002064 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391002065 dimerization interface [polypeptide binding]; other site 1116391002066 Histidine kinase; Region: His_kinase; pfam06580 1116391002067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391002068 ATP binding site [chemical binding]; other site 1116391002069 Mg2+ binding site [ion binding]; other site 1116391002070 G-X-G motif; other site 1116391002071 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1116391002072 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1116391002073 ligand binding site [chemical binding]; other site 1116391002074 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1116391002075 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1116391002076 DNA binding residues [nucleotide binding] 1116391002077 dimer interface [polypeptide binding]; other site 1116391002078 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1116391002079 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391002080 S-adenosylmethionine binding site [chemical binding]; other site 1116391002081 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1116391002082 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1116391002083 dimer interface [polypeptide binding]; other site 1116391002084 ADP-ribose binding site [chemical binding]; other site 1116391002085 active site 1116391002086 nudix motif; other site 1116391002087 metal binding site [ion binding]; metal-binding site 1116391002088 IDEAL domain; Region: IDEAL; cl07452 1116391002089 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1116391002090 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1116391002091 putative active site [active] 1116391002092 putative FMN binding site [chemical binding]; other site 1116391002093 putative substrate binding site [chemical binding]; other site 1116391002094 putative catalytic residue [active] 1116391002095 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391002096 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391002097 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391002098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391002099 dimerization interface [polypeptide binding]; other site 1116391002100 Histidine kinase; Region: His_kinase; pfam06580 1116391002101 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391002102 ATP binding site [chemical binding]; other site 1116391002103 Mg2+ binding site [ion binding]; other site 1116391002104 G-X-G motif; other site 1116391002105 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391002106 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391002107 active site 1116391002108 phosphorylation site [posttranslational modification] 1116391002109 intermolecular recognition site; other site 1116391002110 dimerization interface [polypeptide binding]; other site 1116391002111 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391002112 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391002113 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1116391002114 GntP family permease; Region: GntP_permease; pfam02447 1116391002115 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1116391002116 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1116391002117 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1116391002118 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1116391002119 N- and C-terminal domain interface [polypeptide binding]; other site 1116391002120 active site 1116391002121 catalytic site [active] 1116391002122 metal binding site [ion binding]; metal-binding site 1116391002123 carbohydrate binding site [chemical binding]; other site 1116391002124 ATP binding site [chemical binding]; other site 1116391002125 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1116391002126 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1116391002127 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1116391002128 NAD binding site [chemical binding]; other site 1116391002129 catalytic Zn binding site [ion binding]; other site 1116391002130 structural Zn binding site [ion binding]; other site 1116391002131 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1116391002132 Coat F domain; Region: Coat_F; pfam07875 1116391002133 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1116391002134 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1116391002135 AsnC family; Region: AsnC_trans_reg; pfam01037 1116391002136 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1116391002137 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 1116391002138 active site 1116391002139 putative substrate binding pocket [chemical binding]; other site 1116391002140 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391002141 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1116391002142 TM-ABC transporter signature motif; other site 1116391002143 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391002144 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1116391002145 TM-ABC transporter signature motif; other site 1116391002146 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1116391002147 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1116391002148 Walker A/P-loop; other site 1116391002149 ATP binding site [chemical binding]; other site 1116391002150 Q-loop/lid; other site 1116391002151 ABC transporter signature motif; other site 1116391002152 Walker B; other site 1116391002153 D-loop; other site 1116391002154 H-loop/switch region; other site 1116391002155 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1116391002156 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1116391002157 Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304 1116391002158 ligand binding site [chemical binding]; other site 1116391002159 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1116391002160 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1116391002161 [2Fe-2S] cluster binding site [ion binding]; other site 1116391002162 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1116391002163 hydrophobic ligand binding site; other site 1116391002164 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391002165 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391002166 Protein of unknown function (DUF418); Region: DUF418; cl12135 1116391002167 PhoD-like phosphatase; Region: PhoD; pfam09423 1116391002168 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1116391002169 putative active site [active] 1116391002170 putative metal binding site [ion binding]; other site 1116391002171 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 1116391002172 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1116391002173 classical (c) SDRs; Region: SDR_c; cd05233 1116391002174 NAD(P) binding site [chemical binding]; other site 1116391002175 active site 1116391002176 CAAX protease self-immunity; Region: Abi; pfam02517 1116391002177 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1116391002178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391002179 DNA-binding site [nucleotide binding]; DNA binding site 1116391002180 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391002181 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391002182 homodimer interface [polypeptide binding]; other site 1116391002183 catalytic residue [active] 1116391002184 Lysine efflux permease [General function prediction only]; Region: COG1279 1116391002185 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1116391002186 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1116391002187 putative [4Fe-4S] binding site [ion binding]; other site 1116391002188 putative molybdopterin cofactor binding site [chemical binding]; other site 1116391002189 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1116391002190 putative molybdopterin cofactor binding site; other site 1116391002191 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1116391002192 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1116391002193 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1116391002194 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391002195 dimer interface [polypeptide binding]; other site 1116391002196 putative CheW interface [polypeptide binding]; other site 1116391002197 amino acid transporter; Region: 2A0306; TIGR00909 1116391002198 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1116391002199 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 1116391002200 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 1116391002201 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 1116391002202 urea carboxylase; Region: urea_carbox; TIGR02712 1116391002203 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1116391002204 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1116391002205 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1116391002206 Allophanate hydrolase subunit 2; Region: AHS2; smart00797 1116391002207 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1116391002208 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1116391002209 carboxyltransferase (CT) interaction site; other site 1116391002210 biotinylation site [posttranslational modification]; other site 1116391002211 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1116391002212 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391002213 putative substrate translocation pore; other site 1116391002214 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1116391002215 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1116391002216 [4Fe-4S] binding site [ion binding]; other site 1116391002217 molybdopterin cofactor binding site; other site 1116391002218 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1116391002219 molybdopterin cofactor binding site; other site 1116391002220 Sulfatase; Region: Sulfatase; pfam00884 1116391002221 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391002222 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1116391002223 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1116391002224 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1116391002225 Histidine kinase; Region: HisKA_3; pfam07730 1116391002226 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1116391002227 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1116391002228 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1116391002229 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391002230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391002231 ATP binding site [chemical binding]; other site 1116391002232 G-X-G motif; other site 1116391002233 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391002234 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391002235 active site 1116391002236 phosphorylation site [posttranslational modification] 1116391002237 intermolecular recognition site; other site 1116391002238 dimerization interface [polypeptide binding]; other site 1116391002239 YcbB domain; Region: YcbB; pfam08664 1116391002240 Amb_all domain; Region: Amb_all; smart00656 1116391002241 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391002242 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391002243 dimer interface [polypeptide binding]; other site 1116391002244 conserved gate region; other site 1116391002245 ABC-ATPase subunit interface; other site 1116391002246 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391002247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391002248 dimer interface [polypeptide binding]; other site 1116391002249 conserved gate region; other site 1116391002250 putative PBP binding loops; other site 1116391002251 ABC-ATPase subunit interface; other site 1116391002252 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391002253 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1116391002254 Sodium Bile acid symporter family; Region: SBF; cl17470 1116391002255 S-layer homology domain; Region: SLH; pfam00395 1116391002256 S-layer homology domain; Region: SLH; pfam00395 1116391002257 S-layer homology domain; Region: SLH; pfam00395 1116391002258 Spore germination protein; Region: Spore_permease; cl17796 1116391002259 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391002260 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391002261 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391002262 YCII-related domain; Region: YCII; cl00999 1116391002263 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1116391002264 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1116391002265 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 1116391002266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391002267 Walker A/P-loop; other site 1116391002268 ATP binding site [chemical binding]; other site 1116391002269 Q-loop/lid; other site 1116391002270 ABC transporter signature motif; other site 1116391002271 Walker B; other site 1116391002272 D-loop; other site 1116391002273 H-loop/switch region; other site 1116391002274 TOBE domain; Region: TOBE_2; pfam08402 1116391002275 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 1116391002276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391002277 dimer interface [polypeptide binding]; other site 1116391002278 conserved gate region; other site 1116391002279 putative PBP binding loops; other site 1116391002280 ABC-ATPase subunit interface; other site 1116391002281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391002282 dimer interface [polypeptide binding]; other site 1116391002283 conserved gate region; other site 1116391002284 putative PBP binding loops; other site 1116391002285 ABC-ATPase subunit interface; other site 1116391002286 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1116391002287 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391002288 motif II; other site 1116391002289 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1116391002290 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1116391002291 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1116391002292 catalytic residue [active] 1116391002293 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 1116391002294 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1116391002295 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1116391002296 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1116391002297 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1116391002298 flagellar motor protein MotA; Validated; Region: PRK08124 1116391002299 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1116391002300 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1116391002301 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1116391002302 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1116391002303 ligand binding site [chemical binding]; other site 1116391002304 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 1116391002305 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391002306 Phytase; Region: Phytase; cl17685 1116391002307 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1116391002308 putative active site [active] 1116391002309 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1116391002310 metal ion-dependent adhesion site (MIDAS); other site 1116391002311 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1116391002312 metal ion-dependent adhesion site (MIDAS); other site 1116391002313 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 1116391002314 PAS fold; Region: PAS_4; pfam08448 1116391002315 PAS domain S-box; Region: sensory_box; TIGR00229 1116391002316 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391002317 putative active site [active] 1116391002318 heme pocket [chemical binding]; other site 1116391002319 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391002320 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391002321 metal binding site [ion binding]; metal-binding site 1116391002322 active site 1116391002323 I-site; other site 1116391002324 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1116391002325 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391002326 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391002327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391002328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391002329 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1116391002330 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391002331 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391002332 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391002333 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1116391002334 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1116391002335 Ligand Binding Site [chemical binding]; other site 1116391002336 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1116391002337 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1116391002338 ligand binding site [chemical binding]; other site 1116391002339 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1116391002340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391002341 Walker A/P-loop; other site 1116391002342 ATP binding site [chemical binding]; other site 1116391002343 Q-loop/lid; other site 1116391002344 ABC transporter signature motif; other site 1116391002345 Walker B; other site 1116391002346 D-loop; other site 1116391002347 H-loop/switch region; other site 1116391002348 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1116391002349 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391002350 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1116391002351 TM-ABC transporter signature motif; other site 1116391002352 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391002353 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1116391002354 TM-ABC transporter signature motif; other site 1116391002355 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1116391002356 active site 1116391002357 NTP binding site [chemical binding]; other site 1116391002358 metal binding triad [ion binding]; metal-binding site 1116391002359 antibiotic binding site [chemical binding]; other site 1116391002360 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1116391002361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391002362 S-adenosylmethionine binding site [chemical binding]; other site 1116391002363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391002364 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391002365 putative substrate translocation pore; other site 1116391002366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391002367 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1116391002368 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1116391002369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391002370 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1116391002371 motif II; other site 1116391002372 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391002373 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391002374 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391002375 metal binding site [ion binding]; metal-binding site 1116391002376 active site 1116391002377 I-site; other site 1116391002378 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1116391002379 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1116391002380 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1116391002381 Zn2+ binding site [ion binding]; other site 1116391002382 Mg2+ binding site [ion binding]; other site 1116391002383 S-layer homology domain; Region: SLH; pfam00395 1116391002384 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1116391002385 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1116391002386 active site 1116391002387 metal binding site [ion binding]; metal-binding site 1116391002388 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1116391002389 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1116391002390 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1116391002391 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391002392 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391002393 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1116391002394 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1116391002395 putative active site [active] 1116391002396 metal binding site [ion binding]; metal-binding site 1116391002397 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1116391002398 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1116391002399 putative trimer interface [polypeptide binding]; other site 1116391002400 putative CoA binding site [chemical binding]; other site 1116391002401 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1116391002402 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1116391002403 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1116391002404 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1116391002405 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1116391002406 active site 1116391002407 tetramer interface; other site 1116391002408 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1116391002409 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1116391002410 putative active site [active] 1116391002411 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1116391002412 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1116391002413 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391002414 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1116391002415 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1116391002416 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1116391002417 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391002418 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1116391002419 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1116391002420 active site 1116391002421 dimer interface [polypeptide binding]; other site 1116391002422 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1116391002423 Ligand Binding Site [chemical binding]; other site 1116391002424 Molecular Tunnel; other site 1116391002425 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1116391002426 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 1116391002427 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1116391002428 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1116391002429 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1116391002430 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1116391002431 Chain length determinant protein; Region: Wzz; cl15801 1116391002432 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1116391002433 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1116391002434 dimerization interface [polypeptide binding]; other site 1116391002435 active site 1116391002436 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1116391002437 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1116391002438 folate binding site [chemical binding]; other site 1116391002439 NADP+ binding site [chemical binding]; other site 1116391002440 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391002441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391002442 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391002443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391002444 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1116391002445 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1116391002446 NAD(P) binding site [chemical binding]; other site 1116391002447 LDH/MDH dimer interface [polypeptide binding]; other site 1116391002448 substrate binding site [chemical binding]; other site 1116391002449 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 1116391002450 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391002451 HTH-like domain; Region: HTH_21; pfam13276 1116391002452 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391002453 Integrase core domain; Region: rve; pfam00665 1116391002454 Integrase core domain; Region: rve_3; pfam13683 1116391002455 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391002456 Transposase; Region: HTH_Tnp_1; pfam01527 1116391002457 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1116391002458 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1116391002459 DXD motif; other site 1116391002460 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 1116391002461 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391002462 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391002463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391002464 Walker A/P-loop; other site 1116391002465 ATP binding site [chemical binding]; other site 1116391002466 Q-loop/lid; other site 1116391002467 ABC transporter signature motif; other site 1116391002468 Walker B; other site 1116391002469 D-loop; other site 1116391002470 H-loop/switch region; other site 1116391002471 hypothetical protein; Provisional; Region: PRK10621 1116391002472 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1116391002473 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391002474 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1116391002475 active site 1116391002476 metal binding site [ion binding]; metal-binding site 1116391002477 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1116391002478 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1116391002479 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1116391002480 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1116391002481 NAD binding site [chemical binding]; other site 1116391002482 active site 1116391002483 nicotinate phosphoribosyltransferase; Region: PLN02885 1116391002484 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 1116391002485 Spore germination protein; Region: Spore_permease; cl17796 1116391002486 Spore germination protein; Region: Spore_permease; cl17796 1116391002487 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391002488 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391002489 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391002490 HPP family; Region: HPP; pfam04982 1116391002491 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391002492 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391002493 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391002494 dimerization interface [polypeptide binding]; other site 1116391002495 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1116391002496 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1116391002497 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1116391002498 S-formylglutathione hydrolase; Region: PLN02442 1116391002499 Predicted esterase [General function prediction only]; Region: COG0627 1116391002500 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391002501 active site 1116391002502 phosphorylation site [posttranslational modification] 1116391002503 intermolecular recognition site; other site 1116391002504 dimerization interface [polypeptide binding]; other site 1116391002505 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391002506 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391002507 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391002508 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391002509 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391002510 dimerization interface [polypeptide binding]; other site 1116391002511 Histidine kinase; Region: His_kinase; pfam06580 1116391002512 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391002513 ATP binding site [chemical binding]; other site 1116391002514 Mg2+ binding site [ion binding]; other site 1116391002515 G-X-G motif; other site 1116391002516 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391002517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391002518 dimer interface [polypeptide binding]; other site 1116391002519 conserved gate region; other site 1116391002520 ABC-ATPase subunit interface; other site 1116391002521 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391002522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391002523 dimer interface [polypeptide binding]; other site 1116391002524 conserved gate region; other site 1116391002525 putative PBP binding loops; other site 1116391002526 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391002527 ABC-ATPase subunit interface; other site 1116391002528 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391002529 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391002530 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1116391002531 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1116391002532 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1116391002533 putative trimer interface [polypeptide binding]; other site 1116391002534 putative CoA binding site [chemical binding]; other site 1116391002535 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1116391002536 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1116391002537 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391002538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391002539 dimer interface [polypeptide binding]; other site 1116391002540 conserved gate region; other site 1116391002541 putative PBP binding loops; other site 1116391002542 ABC-ATPase subunit interface; other site 1116391002543 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391002544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391002545 dimer interface [polypeptide binding]; other site 1116391002546 putative PBP binding loops; other site 1116391002547 ABC-ATPase subunit interface; other site 1116391002548 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1116391002549 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1116391002550 active site 1116391002551 ATP binding site [chemical binding]; other site 1116391002552 substrate binding site [chemical binding]; other site 1116391002553 activation loop (A-loop); other site 1116391002554 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1116391002555 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 1116391002556 AAA domain; Region: AAA_31; pfam13614 1116391002557 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 1116391002558 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1116391002559 Walker A motif; other site 1116391002560 ATP binding site [chemical binding]; other site 1116391002561 Walker B motif; other site 1116391002562 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1116391002563 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1116391002564 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 1116391002565 active site 1116391002566 metal-dependent hydrolase; Provisional; Region: PRK13291 1116391002567 DinB superfamily; Region: DinB_2; pfam12867 1116391002568 DinB superfamily; Region: DinB_2; pfam12867 1116391002569 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1116391002570 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391002571 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391002572 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391002573 dimerization interface [polypeptide binding]; other site 1116391002574 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1116391002575 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1116391002576 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1116391002577 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1116391002578 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1116391002579 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1116391002580 GatB domain; Region: GatB_Yqey; smart00845 1116391002581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391002582 Coenzyme A binding pocket [chemical binding]; other site 1116391002583 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1116391002584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1116391002585 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1116391002586 MgtC family; Region: MgtC; pfam02308 1116391002587 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1116391002588 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391002589 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1116391002590 DNA binding residues [nucleotide binding] 1116391002591 Putative zinc-finger; Region: zf-HC2; pfam13490 1116391002592 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 1116391002593 Uncharacterized conserved protein [Function unknown]; Region: COG3595 1116391002594 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1116391002595 ferric uptake regulator; Provisional; Region: fur; PRK09462 1116391002596 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1116391002597 metal binding site 2 [ion binding]; metal-binding site 1116391002598 putative DNA binding helix; other site 1116391002599 metal binding site 1 [ion binding]; metal-binding site 1116391002600 dimer interface [polypeptide binding]; other site 1116391002601 structural Zn2+ binding site [ion binding]; other site 1116391002602 Bacterial SH3 domain; Region: SH3_3; pfam08239 1116391002603 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1116391002604 active site 1116391002605 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 1116391002606 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1116391002607 thiS-thiF/thiG interaction site; other site 1116391002608 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1116391002609 ThiS interaction site; other site 1116391002610 putative active site [active] 1116391002611 tetramer interface [polypeptide binding]; other site 1116391002612 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 1116391002613 active site 1116391002614 catalytic triad [active] 1116391002615 oxyanion hole [active] 1116391002616 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1116391002617 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1116391002618 NodB motif; other site 1116391002619 active site 1116391002620 catalytic site [active] 1116391002621 metal binding site [ion binding]; metal-binding site 1116391002622 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1116391002623 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1116391002624 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1116391002625 putative active site [active] 1116391002626 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1116391002627 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1116391002628 FOG: CBS domain [General function prediction only]; Region: COG0517 1116391002629 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 1116391002630 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 1116391002631 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1116391002632 Moco binding site; other site 1116391002633 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1116391002634 metal coordination site [ion binding]; other site 1116391002635 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1116391002636 MOSC domain; Region: MOSC; pfam03473 1116391002637 3-alpha domain; Region: 3-alpha; pfam03475 1116391002638 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1116391002639 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1116391002640 GTP binding site; other site 1116391002641 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1116391002642 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391002643 FeS/SAM binding site; other site 1116391002644 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1116391002645 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1116391002646 Src Homology 3 domain superfamily; Region: SH3; cd00174 1116391002647 Bacterial SH3 domain; Region: SH3_3; pfam08239 1116391002648 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1116391002649 NlpC/P60 family; Region: NLPC_P60; cl17555 1116391002650 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391002651 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391002652 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1116391002653 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391002654 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391002655 DNA binding residues [nucleotide binding] 1116391002656 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1116391002657 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1116391002658 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 1116391002659 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391002660 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391002661 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1116391002662 active site 1116391002663 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391002664 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1116391002665 active site 1116391002666 metal binding site [ion binding]; metal-binding site 1116391002667 phage shock protein A; Region: phageshock_pspA; TIGR02977 1116391002668 PspC domain; Region: PspC; pfam04024 1116391002669 PspA/IM30 family; Region: PspA_IM30; pfam04012 1116391002670 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1116391002671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1116391002672 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391002673 dimerization interface [polypeptide binding]; other site 1116391002674 Histidine kinase; Region: HisKA_3; pfam07730 1116391002675 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391002676 ATP binding site [chemical binding]; other site 1116391002677 Mg2+ binding site [ion binding]; other site 1116391002678 G-X-G motif; other site 1116391002679 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391002680 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391002681 active site 1116391002682 phosphorylation site [posttranslational modification] 1116391002683 intermolecular recognition site; other site 1116391002684 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391002685 DNA binding residues [nucleotide binding] 1116391002686 dimerization interface [polypeptide binding]; other site 1116391002687 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391002688 Coenzyme A binding pocket [chemical binding]; other site 1116391002689 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1116391002690 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 1116391002691 sugar binding site [chemical binding]; other site 1116391002692 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1116391002693 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1116391002694 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391002695 Interdomain contacts; other site 1116391002696 S-layer homology domain; Region: SLH; pfam00395 1116391002697 S-layer homology domain; Region: SLH; pfam00395 1116391002698 S-layer homology domain; Region: SLH; pfam00395 1116391002699 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1116391002700 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1116391002701 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1116391002702 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1116391002703 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391002704 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1116391002705 active site 1116391002706 metal binding site [ion binding]; metal-binding site 1116391002707 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1116391002708 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1116391002709 G1 box; other site 1116391002710 putative GEF interaction site [polypeptide binding]; other site 1116391002711 GTP/Mg2+ binding site [chemical binding]; other site 1116391002712 Switch I region; other site 1116391002713 G2 box; other site 1116391002714 G3 box; other site 1116391002715 Switch II region; other site 1116391002716 G4 box; other site 1116391002717 G5 box; other site 1116391002718 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1116391002719 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391002720 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1116391002721 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1116391002722 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391002723 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391002724 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391002725 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1116391002726 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391002727 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391002728 Small, acid-soluble spore protein I; Region: SSPI; cl07940 1116391002729 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1116391002730 TrkA-N domain; Region: TrkA_N; pfam02254 1116391002731 TrkA-C domain; Region: TrkA_C; pfam02080 1116391002732 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1116391002733 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1116391002734 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1116391002735 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1116391002736 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1116391002737 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391002738 MarR family; Region: MarR_2; pfam12802 1116391002739 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391002740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391002741 active site 1116391002742 phosphorylation site [posttranslational modification] 1116391002743 intermolecular recognition site; other site 1116391002744 dimerization interface [polypeptide binding]; other site 1116391002745 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391002746 DNA binding site [nucleotide binding] 1116391002747 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391002748 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391002749 dimerization interface [polypeptide binding]; other site 1116391002750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391002751 dimer interface [polypeptide binding]; other site 1116391002752 phosphorylation site [posttranslational modification] 1116391002753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391002754 ATP binding site [chemical binding]; other site 1116391002755 Mg2+ binding site [ion binding]; other site 1116391002756 G-X-G motif; other site 1116391002757 VPS10 domain; Region: VPS10; smart00602 1116391002758 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1116391002759 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 1116391002760 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1116391002761 putative transporter; Provisional; Region: PRK10054 1116391002762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391002763 putative substrate translocation pore; other site 1116391002764 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1116391002765 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1116391002766 putative active site [active] 1116391002767 catalytic site [active] 1116391002768 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1116391002769 putative active site [active] 1116391002770 catalytic site [active] 1116391002771 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1116391002772 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1116391002773 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1116391002774 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1116391002775 Walker A/P-loop; other site 1116391002776 ATP binding site [chemical binding]; other site 1116391002777 Q-loop/lid; other site 1116391002778 ABC transporter signature motif; other site 1116391002779 Walker B; other site 1116391002780 D-loop; other site 1116391002781 H-loop/switch region; other site 1116391002782 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 1116391002783 cobalt transport protein CbiN; Provisional; Region: PRK02898 1116391002784 cobalt transport protein CbiM; Validated; Region: PRK08319 1116391002785 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 1116391002786 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 1116391002787 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1116391002788 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1116391002789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391002790 dimer interface [polypeptide binding]; other site 1116391002791 conserved gate region; other site 1116391002792 putative PBP binding loops; other site 1116391002793 ABC-ATPase subunit interface; other site 1116391002794 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1116391002795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391002796 dimer interface [polypeptide binding]; other site 1116391002797 conserved gate region; other site 1116391002798 putative PBP binding loops; other site 1116391002799 ABC-ATPase subunit interface; other site 1116391002800 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1116391002801 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391002802 Walker A/P-loop; other site 1116391002803 ATP binding site [chemical binding]; other site 1116391002804 Q-loop/lid; other site 1116391002805 ABC transporter signature motif; other site 1116391002806 Walker B; other site 1116391002807 D-loop; other site 1116391002808 H-loop/switch region; other site 1116391002809 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1116391002810 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391002811 Walker A/P-loop; other site 1116391002812 ATP binding site [chemical binding]; other site 1116391002813 Q-loop/lid; other site 1116391002814 ABC transporter signature motif; other site 1116391002815 Predicted membrane protein [Function unknown]; Region: COG1511 1116391002816 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1116391002817 Predicted membrane protein [Function unknown]; Region: COG1511 1116391002818 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1116391002819 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1116391002820 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391002821 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391002822 DNA binding site [nucleotide binding] 1116391002823 domain linker motif; other site 1116391002824 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1116391002825 dimerization interface [polypeptide binding]; other site 1116391002826 ligand binding site [chemical binding]; other site 1116391002827 sodium binding site [ion binding]; other site 1116391002828 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391002829 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391002830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391002831 dimer interface [polypeptide binding]; other site 1116391002832 conserved gate region; other site 1116391002833 putative PBP binding loops; other site 1116391002834 ABC-ATPase subunit interface; other site 1116391002835 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391002836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391002837 dimer interface [polypeptide binding]; other site 1116391002838 conserved gate region; other site 1116391002839 putative PBP binding loops; other site 1116391002840 ABC-ATPase subunit interface; other site 1116391002841 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1116391002842 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1116391002843 substrate binding [chemical binding]; other site 1116391002844 active site 1116391002845 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1116391002846 azoreductase; Reviewed; Region: PRK00170 1116391002847 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1116391002848 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391002849 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391002850 active site 1116391002851 catalytic tetrad [active] 1116391002852 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1116391002853 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1116391002854 NAD(P) binding site [chemical binding]; other site 1116391002855 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1116391002856 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1116391002857 catalytic residues [active] 1116391002858 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391002859 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391002860 DNA binding residues [nucleotide binding] 1116391002861 dimerization interface [polypeptide binding]; other site 1116391002862 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 1116391002863 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1116391002864 PYR/PP interface [polypeptide binding]; other site 1116391002865 dimer interface [polypeptide binding]; other site 1116391002866 TPP binding site [chemical binding]; other site 1116391002867 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1116391002868 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1116391002869 TPP-binding site [chemical binding]; other site 1116391002870 dimer interface [polypeptide binding]; other site 1116391002871 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1116391002872 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1116391002873 putative valine binding site [chemical binding]; other site 1116391002874 dimer interface [polypeptide binding]; other site 1116391002875 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1116391002876 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391002877 dimerization interface [polypeptide binding]; other site 1116391002878 putative DNA binding site [nucleotide binding]; other site 1116391002879 putative Zn2+ binding site [ion binding]; other site 1116391002880 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391002881 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391002882 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391002883 dimerization interface [polypeptide binding]; other site 1116391002884 DinB superfamily; Region: DinB_2; pfam12867 1116391002885 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 1116391002886 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1116391002887 Peptidase family M23; Region: Peptidase_M23; pfam01551 1116391002888 Protein of unknown function DUF111; Region: DUF111; cl03398 1116391002889 hypothetical protein; Provisional; Region: PRK04194 1116391002890 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 1116391002891 AIR carboxylase; Region: AIRC; smart01001 1116391002892 lipoyl synthase; Provisional; Region: PRK05481 1116391002893 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391002894 FeS/SAM binding site; other site 1116391002895 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1116391002896 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1116391002897 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1116391002898 PilZ domain; Region: PilZ; pfam07238 1116391002899 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 1116391002900 putative homodimer interface [polypeptide binding]; other site 1116391002901 putative active site pocket [active] 1116391002902 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 1116391002903 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1116391002904 Nucleoside recognition; Region: Gate; pfam07670 1116391002905 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1116391002906 apolar tunnel; other site 1116391002907 heme binding site [chemical binding]; other site 1116391002908 dimerization interface [polypeptide binding]; other site 1116391002909 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 1116391002910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 1116391002911 YycC-like protein; Region: YycC; pfam14174 1116391002912 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1116391002913 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391002914 dimer interface [polypeptide binding]; other site 1116391002915 putative metal binding site [ion binding]; other site 1116391002916 General stress protein [General function prediction only]; Region: GsiB; COG3729 1116391002917 General stress protein [General function prediction only]; Region: GsiB; COG3729 1116391002918 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1116391002919 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1116391002920 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1116391002921 putative active site [active] 1116391002922 putative metal binding site [ion binding]; other site 1116391002923 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1116391002924 active site 1116391002925 catalytic residues [active] 1116391002926 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 1116391002927 TIGR03943 family protein; Region: TIGR03943 1116391002928 Predicted permease; Region: DUF318; cl17795 1116391002929 Predicted permease; Region: DUF318; cl17795 1116391002930 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1116391002931 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1116391002932 active site 1116391002933 HIGH motif; other site 1116391002934 dimer interface [polypeptide binding]; other site 1116391002935 KMSKS motif; other site 1116391002936 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1116391002937 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391002938 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391002939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391002940 Walker A/P-loop; other site 1116391002941 ATP binding site [chemical binding]; other site 1116391002942 Q-loop/lid; other site 1116391002943 ABC transporter signature motif; other site 1116391002944 Walker B; other site 1116391002945 D-loop; other site 1116391002946 H-loop/switch region; other site 1116391002947 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391002948 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391002949 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1116391002950 Walker A/P-loop; other site 1116391002951 ATP binding site [chemical binding]; other site 1116391002952 Q-loop/lid; other site 1116391002953 ABC transporter signature motif; other site 1116391002954 Walker B; other site 1116391002955 D-loop; other site 1116391002956 H-loop/switch region; other site 1116391002957 Cupin domain; Region: Cupin_2; pfam07883 1116391002958 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391002959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391002960 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1116391002961 beta-galactosidase; Region: BGL; TIGR03356 1116391002962 MFS/sugar transport protein; Region: MFS_2; pfam13347 1116391002963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391002964 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1116391002965 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1116391002966 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1116391002967 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 1116391002968 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391002969 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1116391002970 E-class dimer interface [polypeptide binding]; other site 1116391002971 P-class dimer interface [polypeptide binding]; other site 1116391002972 active site 1116391002973 Cu2+ binding site [ion binding]; other site 1116391002974 Zn2+ binding site [ion binding]; other site 1116391002975 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391002976 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391002977 active site 1116391002978 catalytic tetrad [active] 1116391002979 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1116391002980 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1116391002981 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1116391002982 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 1116391002983 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1116391002984 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1116391002985 DHHA2 domain; Region: DHHA2; pfam02833 1116391002986 Amb_all domain; Region: Amb_all; smart00656 1116391002987 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1116391002988 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1116391002989 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1116391002990 NAD binding site [chemical binding]; other site 1116391002991 dimer interface [polypeptide binding]; other site 1116391002992 substrate binding site [chemical binding]; other site 1116391002993 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1116391002994 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1116391002995 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1116391002996 DinB superfamily; Region: DinB_2; pfam12867 1116391002997 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1116391002998 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1116391002999 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391003000 NAD(P) binding site [chemical binding]; other site 1116391003001 active site 1116391003002 short chain dehydrogenase; Provisional; Region: PRK06914 1116391003003 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1116391003004 NADP binding site [chemical binding]; other site 1116391003005 active site 1116391003006 steroid binding site; other site 1116391003007 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391003008 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391003009 active site 1116391003010 catalytic tetrad [active] 1116391003011 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1116391003012 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1116391003013 Walker A/P-loop; other site 1116391003014 ATP binding site [chemical binding]; other site 1116391003015 Q-loop/lid; other site 1116391003016 ABC transporter signature motif; other site 1116391003017 Walker B; other site 1116391003018 D-loop; other site 1116391003019 H-loop/switch region; other site 1116391003020 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1116391003021 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1116391003022 Walker A/P-loop; other site 1116391003023 ATP binding site [chemical binding]; other site 1116391003024 Q-loop/lid; other site 1116391003025 ABC transporter signature motif; other site 1116391003026 Walker B; other site 1116391003027 D-loop; other site 1116391003028 H-loop/switch region; other site 1116391003029 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1116391003030 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1116391003031 TM-ABC transporter signature motif; other site 1116391003032 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1116391003033 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391003034 TM-ABC transporter signature motif; other site 1116391003035 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1116391003036 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1116391003037 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1116391003038 alpha-gamma subunit interface [polypeptide binding]; other site 1116391003039 beta-gamma subunit interface [polypeptide binding]; other site 1116391003040 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1116391003041 gamma-beta subunit interface [polypeptide binding]; other site 1116391003042 alpha-beta subunit interface [polypeptide binding]; other site 1116391003043 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1116391003044 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1116391003045 subunit interactions [polypeptide binding]; other site 1116391003046 active site 1116391003047 flap region; other site 1116391003048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391003049 Walker A motif; other site 1116391003050 ATP binding site [chemical binding]; other site 1116391003051 arginine finger; other site 1116391003052 UreD urease accessory protein; Region: UreD; cl00530 1116391003053 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1116391003054 UbiA prenyltransferase family; Region: UbiA; pfam01040 1116391003055 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1116391003056 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1116391003057 Cu(I) binding site [ion binding]; other site 1116391003058 Predicted permeases [General function prediction only]; Region: COG0679 1116391003059 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1116391003060 active site 1116391003061 metal binding site [ion binding]; metal-binding site 1116391003062 S-layer homology domain; Region: SLH; pfam00395 1116391003063 S-layer homology domain; Region: SLH; pfam00395 1116391003064 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391003065 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391003066 putative substrate translocation pore; other site 1116391003067 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1116391003068 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1116391003069 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1116391003070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391003071 motif II; other site 1116391003072 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1116391003073 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1116391003074 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1116391003075 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1116391003076 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1116391003077 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1116391003078 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1116391003079 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1116391003080 intersubunit interface [polypeptide binding]; other site 1116391003081 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1116391003082 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1116391003083 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1116391003084 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391003085 ABC-ATPase subunit interface; other site 1116391003086 dimer interface [polypeptide binding]; other site 1116391003087 putative PBP binding regions; other site 1116391003088 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1116391003089 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1116391003090 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1116391003091 active site 1116391003092 dimer interface [polypeptide binding]; other site 1116391003093 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1116391003094 Ligand Binding Site [chemical binding]; other site 1116391003095 Molecular Tunnel; other site 1116391003096 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1116391003097 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391003098 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1116391003099 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1116391003100 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1116391003101 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1116391003102 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1116391003103 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391003104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 1116391003105 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1116391003106 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 1116391003107 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1116391003108 catalytic residues [active] 1116391003109 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1116391003110 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1116391003111 EamA-like transporter family; Region: EamA; pfam00892 1116391003112 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1116391003113 EamA-like transporter family; Region: EamA; pfam00892 1116391003114 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1116391003115 classical (c) SDRs; Region: SDR_c; cd05233 1116391003116 NAD(P) binding site [chemical binding]; other site 1116391003117 active site 1116391003118 NifU-like domain; Region: NifU; cl00484 1116391003119 hypothetical protein; Provisional; Region: PRK13669 1116391003120 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1116391003121 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1116391003122 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 1116391003123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391003124 FeS/SAM binding site; other site 1116391003125 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1116391003126 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1116391003127 Tic20-like protein; Region: Tic20; pfam09685 1116391003128 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1116391003129 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1116391003130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1116391003131 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1116391003132 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1116391003133 Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858 1116391003134 Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in bacterial endospore germination. CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells. SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874 1116391003135 active site 1116391003136 putative heme peroxidase; Provisional; Region: PRK12276 1116391003137 Putative membrane protein; Region: YuiB; pfam14068 1116391003138 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1116391003139 primosomal protein DnaI; Reviewed; Region: PRK08939 1116391003140 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391003141 Walker A motif; other site 1116391003142 ATP binding site [chemical binding]; other site 1116391003143 Walker B motif; other site 1116391003144 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1116391003145 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1116391003146 catalytic residues [active] 1116391003147 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1116391003148 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1116391003149 GIY-YIG motif/motif A; other site 1116391003150 active site 1116391003151 catalytic site [active] 1116391003152 putative DNA binding site [nucleotide binding]; other site 1116391003153 metal binding site [ion binding]; metal-binding site 1116391003154 UvrB/uvrC motif; Region: UVR; pfam02151 1116391003155 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1116391003156 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1116391003157 DNA binding site [nucleotide binding] 1116391003158 CAAX protease self-immunity; Region: Abi; pfam02517 1116391003159 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1116391003160 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1116391003161 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1116391003162 TrkA-N domain; Region: TrkA_N; pfam02254 1116391003163 TrkA-C domain; Region: TrkA_C; pfam02080 1116391003164 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1116391003165 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1116391003166 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391003167 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391003168 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391003169 dimerization interface [polypeptide binding]; other site 1116391003170 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1116391003171 putative Iron-sulfur protein interface [polypeptide binding]; other site 1116391003172 proximal heme binding site [chemical binding]; other site 1116391003173 distal heme binding site [chemical binding]; other site 1116391003174 putative dimer interface [polypeptide binding]; other site 1116391003175 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1116391003176 L-aspartate oxidase; Provisional; Region: PRK06175 1116391003177 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1116391003178 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1116391003179 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1116391003180 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391003181 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391003182 DNA binding site [nucleotide binding] 1116391003183 domain linker motif; other site 1116391003184 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1116391003185 ligand binding site [chemical binding]; other site 1116391003186 dimerization interface [polypeptide binding]; other site 1116391003187 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1116391003188 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1116391003189 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1116391003190 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1116391003191 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1116391003192 Histidine kinase; Region: HisKA_3; pfam07730 1116391003193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391003194 ATP binding site [chemical binding]; other site 1116391003195 Mg2+ binding site [ion binding]; other site 1116391003196 G-X-G motif; other site 1116391003197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391003198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391003199 active site 1116391003200 phosphorylation site [posttranslational modification] 1116391003201 intermolecular recognition site; other site 1116391003202 dimerization interface [polypeptide binding]; other site 1116391003203 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391003204 DNA binding residues [nucleotide binding] 1116391003205 dimerization interface [polypeptide binding]; other site 1116391003206 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1116391003207 Putative sensor; Region: Sensor; pfam13796 1116391003208 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1116391003209 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1116391003210 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391003211 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391003212 active site 1116391003213 phosphorylation site [posttranslational modification] 1116391003214 intermolecular recognition site; other site 1116391003215 dimerization interface [polypeptide binding]; other site 1116391003216 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391003217 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391003219 dimerization interface [polypeptide binding]; other site 1116391003220 Histidine kinase; Region: His_kinase; pfam06580 1116391003221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391003222 ATP binding site [chemical binding]; other site 1116391003223 Mg2+ binding site [ion binding]; other site 1116391003224 G-X-G motif; other site 1116391003225 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391003226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003227 dimer interface [polypeptide binding]; other site 1116391003228 conserved gate region; other site 1116391003229 ABC-ATPase subunit interface; other site 1116391003230 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391003231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003232 dimer interface [polypeptide binding]; other site 1116391003233 conserved gate region; other site 1116391003234 putative PBP binding loops; other site 1116391003235 ABC-ATPase subunit interface; other site 1116391003236 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1116391003237 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391003238 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391003239 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391003240 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1116391003241 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391003242 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391003243 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391003244 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391003245 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1116391003246 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391003247 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003248 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391003249 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003250 dimer interface [polypeptide binding]; other site 1116391003251 conserved gate region; other site 1116391003252 ABC-ATPase subunit interface; other site 1116391003253 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391003254 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003255 dimer interface [polypeptide binding]; other site 1116391003256 conserved gate region; other site 1116391003257 putative PBP binding loops; other site 1116391003258 ABC-ATPase subunit interface; other site 1116391003259 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391003260 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1116391003261 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1116391003262 Pectate lyase; Region: Pec_lyase_C; cl01593 1116391003263 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1116391003264 synthetase active site [active] 1116391003265 NTP binding site [chemical binding]; other site 1116391003266 metal binding site [ion binding]; metal-binding site 1116391003267 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1116391003268 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391003269 sequence-specific DNA binding site [nucleotide binding]; other site 1116391003270 salt bridge; other site 1116391003271 Cupin domain; Region: Cupin_2; pfam07883 1116391003272 LysE type translocator; Region: LysE; cl00565 1116391003273 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1116391003274 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1116391003275 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1116391003276 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1116391003277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391003278 putative substrate translocation pore; other site 1116391003279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391003280 putative DNA binding site [nucleotide binding]; other site 1116391003281 dimerization interface [polypeptide binding]; other site 1116391003282 putative Zn2+ binding site [ion binding]; other site 1116391003283 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1116391003284 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1116391003285 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1116391003286 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1116391003287 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1116391003288 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1116391003289 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1116391003290 Walker A/P-loop; other site 1116391003291 ATP binding site [chemical binding]; other site 1116391003292 Q-loop/lid; other site 1116391003293 ABC transporter signature motif; other site 1116391003294 Walker B; other site 1116391003295 D-loop; other site 1116391003296 H-loop/switch region; other site 1116391003297 TOBE domain; Region: TOBE_2; pfam08402 1116391003298 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391003299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003300 dimer interface [polypeptide binding]; other site 1116391003301 putative PBP binding loops; other site 1116391003302 ABC-ATPase subunit interface; other site 1116391003303 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391003304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003305 dimer interface [polypeptide binding]; other site 1116391003306 conserved gate region; other site 1116391003307 ABC-ATPase subunit interface; other site 1116391003308 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391003309 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1116391003310 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1116391003311 Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565 1116391003312 active site 1116391003313 catalytic site [active] 1116391003314 metal binding site [ion binding]; metal-binding site 1116391003315 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1116391003316 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1116391003317 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391003318 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391003319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003320 dimer interface [polypeptide binding]; other site 1116391003321 ABC-ATPase subunit interface; other site 1116391003322 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391003323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003324 dimer interface [polypeptide binding]; other site 1116391003325 conserved gate region; other site 1116391003326 putative PBP binding loops; other site 1116391003327 ABC-ATPase subunit interface; other site 1116391003328 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 1116391003329 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1116391003330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391003331 Coenzyme A binding pocket [chemical binding]; other site 1116391003332 Predicted membrane protein [Function unknown]; Region: COG2311 1116391003333 Protein of unknown function (DUF418); Region: DUF418; pfam04235 1116391003334 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 1116391003335 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1116391003336 active site 1116391003337 substrate binding site [chemical binding]; other site 1116391003338 trimer interface [polypeptide binding]; other site 1116391003339 CoA binding site [chemical binding]; other site 1116391003340 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1116391003341 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1116391003342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003343 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003344 short chain dehydrogenase; Provisional; Region: PRK12747 1116391003345 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1116391003346 NADP binding site [chemical binding]; other site 1116391003347 homodimer interface [polypeptide binding]; other site 1116391003348 active site 1116391003349 substrate binding site [chemical binding]; other site 1116391003350 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 1116391003351 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391003352 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1116391003353 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1116391003354 DoxX-like family; Region: DoxX_2; pfam13564 1116391003355 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1116391003356 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1116391003357 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391003358 H+ Antiporter protein; Region: 2A0121; TIGR00900 1116391003359 putative substrate translocation pore; other site 1116391003360 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1116391003361 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1116391003362 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1116391003363 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1116391003364 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1116391003365 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1116391003366 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1116391003367 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1116391003368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1116391003369 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391003370 Coenzyme A binding pocket [chemical binding]; other site 1116391003371 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391003372 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1116391003373 NAD(P) binding site [chemical binding]; other site 1116391003374 active site 1116391003375 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1116391003376 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1116391003377 DNA binding residues [nucleotide binding] 1116391003378 putative dimer interface [polypeptide binding]; other site 1116391003379 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1116391003380 putative dimer interface [polypeptide binding]; other site 1116391003381 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391003382 DinB superfamily; Region: DinB_2; pfam12867 1116391003383 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391003384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003385 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1116391003386 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1116391003387 homotrimer interaction site [polypeptide binding]; other site 1116391003388 putative active site [active] 1116391003389 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391003390 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003391 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391003392 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1116391003393 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1116391003394 Transposase domain (DUF772); Region: DUF772; pfam05598 1116391003395 Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718 1116391003396 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391003397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391003398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003399 putative PBP binding loops; other site 1116391003400 dimer interface [polypeptide binding]; other site 1116391003401 ABC-ATPase subunit interface; other site 1116391003402 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391003403 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003404 dimer interface [polypeptide binding]; other site 1116391003405 conserved gate region; other site 1116391003406 putative PBP binding loops; other site 1116391003407 ABC-ATPase subunit interface; other site 1116391003408 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391003409 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1116391003410 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 1116391003411 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1116391003412 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1116391003413 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1116391003414 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1116391003415 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391003416 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391003417 DNA binding site [nucleotide binding] 1116391003418 domain linker motif; other site 1116391003419 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1116391003420 dimerization interface [polypeptide binding]; other site 1116391003421 ligand binding site [chemical binding]; other site 1116391003422 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391003423 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391003424 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391003425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003426 dimer interface [polypeptide binding]; other site 1116391003427 conserved gate region; other site 1116391003428 putative PBP binding loops; other site 1116391003429 ABC-ATPase subunit interface; other site 1116391003430 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391003431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003432 dimer interface [polypeptide binding]; other site 1116391003433 conserved gate region; other site 1116391003434 putative PBP binding loops; other site 1116391003435 ABC-ATPase subunit interface; other site 1116391003436 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1116391003437 beta-galactosidase; Region: BGL; TIGR03356 1116391003438 S-layer homology domain; Region: SLH; pfam00395 1116391003439 S-layer homology domain; Region: SLH; pfam00395 1116391003440 S-layer homology domain; Region: SLH; pfam00395 1116391003441 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1116391003442 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1116391003443 active site 1116391003444 catalytic residues [active] 1116391003445 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1116391003446 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1116391003447 metal binding site [ion binding]; metal-binding site 1116391003448 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1116391003449 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1116391003450 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391003451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391003452 active site 1116391003453 phosphorylation site [posttranslational modification] 1116391003454 intermolecular recognition site; other site 1116391003455 dimerization interface [polypeptide binding]; other site 1116391003456 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391003457 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391003459 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391003460 dimerization interface [polypeptide binding]; other site 1116391003461 Histidine kinase; Region: His_kinase; pfam06580 1116391003462 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391003463 ATP binding site [chemical binding]; other site 1116391003464 Mg2+ binding site [ion binding]; other site 1116391003465 G-X-G motif; other site 1116391003466 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391003467 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391003468 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1116391003469 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1116391003470 active site 1116391003471 active site 1116391003472 catalytic residues [active] 1116391003473 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1116391003474 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1116391003475 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391003476 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1116391003477 active site 1116391003478 metal binding site [ion binding]; metal-binding site 1116391003479 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391003480 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391003481 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391003482 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391003483 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391003484 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391003485 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391003486 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391003487 Interdomain contacts; other site 1116391003488 Cytokine receptor motif; other site 1116391003489 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391003490 Interdomain contacts; other site 1116391003491 Cytokine receptor motif; other site 1116391003492 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391003493 Interdomain contacts; other site 1116391003494 Cytokine receptor motif; other site 1116391003495 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 1116391003496 dockerin binding interface; other site 1116391003497 BCCT family transporter; Region: BCCT; pfam02028 1116391003498 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1116391003499 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1116391003500 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1116391003501 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391003502 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391003503 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1116391003504 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1116391003505 Cache domain; Region: Cache_1; pfam02743 1116391003506 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1116391003507 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391003508 dimerization interface [polypeptide binding]; other site 1116391003509 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391003510 dimer interface [polypeptide binding]; other site 1116391003511 putative CheW interface [polypeptide binding]; other site 1116391003512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391003513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391003514 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1116391003515 putative dimerization interface [polypeptide binding]; other site 1116391003516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391003517 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391003518 putative substrate translocation pore; other site 1116391003519 Nitronate monooxygenase; Region: NMO; pfam03060 1116391003520 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1116391003521 FMN binding site [chemical binding]; other site 1116391003522 substrate binding site [chemical binding]; other site 1116391003523 putative catalytic residue [active] 1116391003524 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1116391003525 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1116391003526 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1116391003527 binding surface 1116391003528 TPR motif; other site 1116391003529 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1116391003530 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391003531 DinB family; Region: DinB; cl17821 1116391003532 DinB superfamily; Region: DinB_2; pfam12867 1116391003533 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391003534 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391003535 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1116391003536 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1116391003537 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391003538 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391003539 active site 1116391003540 catalytic tetrad [active] 1116391003541 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1116391003542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391003543 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391003544 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391003545 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391003546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391003547 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391003548 dimerization interface [polypeptide binding]; other site 1116391003549 putative DNA binding site [nucleotide binding]; other site 1116391003550 putative Zn2+ binding site [ion binding]; other site 1116391003551 arsenical pump membrane protein; Provisional; Region: PRK15445 1116391003552 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1116391003553 transmembrane helices; other site 1116391003554 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1116391003555 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1116391003556 active site 1116391003557 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1116391003558 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391003559 putative metal binding site [ion binding]; other site 1116391003560 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1116391003561 active site 1116391003562 catalytic residues [active] 1116391003563 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1116391003564 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1116391003565 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 1116391003566 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391003567 putative metal binding site [ion binding]; other site 1116391003568 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1116391003569 MarR family; Region: MarR_2; cl17246 1116391003570 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1116391003571 FtsX-like permease family; Region: FtsX; pfam02687 1116391003572 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1116391003573 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1116391003574 Walker A/P-loop; other site 1116391003575 ATP binding site [chemical binding]; other site 1116391003576 Q-loop/lid; other site 1116391003577 ABC transporter signature motif; other site 1116391003578 Walker B; other site 1116391003579 D-loop; other site 1116391003580 H-loop/switch region; other site 1116391003581 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391003582 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391003583 dimer interface [polypeptide binding]; other site 1116391003584 phosphorylation site [posttranslational modification] 1116391003585 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391003586 ATP binding site [chemical binding]; other site 1116391003587 Mg2+ binding site [ion binding]; other site 1116391003588 G-X-G motif; other site 1116391003589 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391003590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391003591 intermolecular recognition site; other site 1116391003592 active site 1116391003593 dimerization interface [polypeptide binding]; other site 1116391003594 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391003595 DNA binding site [nucleotide binding] 1116391003596 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391003597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003598 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391003599 RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638 1116391003600 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391003601 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003602 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003603 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391003604 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391003605 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1116391003606 active site 1116391003607 metal binding site [ion binding]; metal-binding site 1116391003608 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1116391003609 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1116391003610 DNA binding residues [nucleotide binding] 1116391003611 drug binding residues [chemical binding]; other site 1116391003612 dimer interface [polypeptide binding]; other site 1116391003613 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1116391003614 short chain dehydrogenase; Provisional; Region: PRK12747 1116391003615 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1116391003616 NADP binding site [chemical binding]; other site 1116391003617 homodimer interface [polypeptide binding]; other site 1116391003618 active site 1116391003619 substrate binding site [chemical binding]; other site 1116391003620 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1116391003621 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1116391003622 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1116391003623 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1116391003624 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1116391003625 putative substrate binding site [chemical binding]; other site 1116391003626 putative ATP binding site [chemical binding]; other site 1116391003627 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1116391003628 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1116391003629 active site 1116391003630 P-loop; other site 1116391003631 phosphorylation site [posttranslational modification] 1116391003632 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1116391003633 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1116391003634 active site 1116391003635 phosphorylation site [posttranslational modification] 1116391003636 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1116391003637 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1116391003638 active site 1116391003639 catalytic triad [active] 1116391003640 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 1116391003641 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 1116391003642 NAD(P) binding site [chemical binding]; other site 1116391003643 catalytic residues [active] 1116391003644 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391003645 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391003646 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1116391003647 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1116391003648 ligand binding site [chemical binding]; other site 1116391003649 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391003650 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391003651 active site 1116391003652 phosphorylation site [posttranslational modification] 1116391003653 intermolecular recognition site; other site 1116391003654 dimerization interface [polypeptide binding]; other site 1116391003655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003656 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391003657 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003658 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391003659 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391003660 dimerization interface [polypeptide binding]; other site 1116391003661 Histidine kinase; Region: His_kinase; pfam06580 1116391003662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391003663 ATP binding site [chemical binding]; other site 1116391003664 Mg2+ binding site [ion binding]; other site 1116391003665 G-X-G motif; other site 1116391003666 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1116391003667 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1116391003668 putative ligand binding site [chemical binding]; other site 1116391003669 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1116391003670 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1116391003671 Walker A/P-loop; other site 1116391003672 ATP binding site [chemical binding]; other site 1116391003673 Q-loop/lid; other site 1116391003674 ABC transporter signature motif; other site 1116391003675 Walker B; other site 1116391003676 D-loop; other site 1116391003677 H-loop/switch region; other site 1116391003678 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1116391003679 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391003680 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1116391003681 TM-ABC transporter signature motif; other site 1116391003682 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391003683 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1116391003684 TM-ABC transporter signature motif; other site 1116391003685 LrgB-like family; Region: LrgB; cl00596 1116391003686 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1116391003687 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391003688 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391003689 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 1116391003690 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391003691 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391003692 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391003693 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391003694 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003695 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391003696 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003697 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1116391003698 putative active site [active] 1116391003699 putative metal binding site [ion binding]; other site 1116391003700 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391003701 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 1116391003702 putative hydrophobic ligand binding site [chemical binding]; other site 1116391003703 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar1; cd08583 1116391003704 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1116391003705 putative active site [active] 1116391003706 catalytic site [active] 1116391003707 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391003708 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1116391003709 active site 1116391003710 metal binding site [ion binding]; metal-binding site 1116391003711 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1116391003712 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1116391003713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003714 dimer interface [polypeptide binding]; other site 1116391003715 conserved gate region; other site 1116391003716 ABC-ATPase subunit interface; other site 1116391003717 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1116391003718 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1116391003719 Walker A/P-loop; other site 1116391003720 ATP binding site [chemical binding]; other site 1116391003721 Q-loop/lid; other site 1116391003722 ABC transporter signature motif; other site 1116391003723 Walker B; other site 1116391003724 D-loop; other site 1116391003725 H-loop/switch region; other site 1116391003726 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1116391003727 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1116391003728 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1116391003729 substrate binding site [chemical binding]; other site 1116391003730 dimer interface [polypeptide binding]; other site 1116391003731 ATP binding site [chemical binding]; other site 1116391003732 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 1116391003733 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391003734 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391003735 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391003736 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391003737 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1116391003738 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1116391003739 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1116391003740 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391003741 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391003742 active site 1116391003743 catalytic tetrad [active] 1116391003744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391003745 putative substrate translocation pore; other site 1116391003746 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391003747 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1116391003748 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1116391003749 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1116391003750 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1116391003751 metal binding site [ion binding]; metal-binding site 1116391003752 Carbohydrate binding module (family 6); Region: CBM_6; pfam03422 1116391003753 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1116391003754 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1116391003755 metal binding site [ion binding]; metal-binding site 1116391003756 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1116391003757 Fn3 associated; Region: Fn3_assoc; pfam13287 1116391003758 S-layer homology domain; Region: SLH; pfam00395 1116391003759 S-layer homology domain; Region: SLH; pfam00395 1116391003760 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1116391003761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391003762 non-specific DNA binding site [nucleotide binding]; other site 1116391003763 salt bridge; other site 1116391003764 sequence-specific DNA binding site [nucleotide binding]; other site 1116391003765 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1116391003766 SpoVR like protein; Region: SpoVR; pfam04293 1116391003767 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1116391003768 asparagine synthetase AsnA; Provisional; Region: PRK05425 1116391003769 motif 1; other site 1116391003770 dimer interface [polypeptide binding]; other site 1116391003771 active site 1116391003772 motif 2; other site 1116391003773 motif 3; other site 1116391003774 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1116391003775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391003776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391003777 dimer interface [polypeptide binding]; other site 1116391003778 phosphorylation site [posttranslational modification] 1116391003779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391003780 ATP binding site [chemical binding]; other site 1116391003781 Mg2+ binding site [ion binding]; other site 1116391003782 G-X-G motif; other site 1116391003783 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391003784 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391003785 active site 1116391003786 phosphorylation site [posttranslational modification] 1116391003787 intermolecular recognition site; other site 1116391003788 dimerization interface [polypeptide binding]; other site 1116391003789 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391003790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391003791 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391003792 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391003793 dimerization interface [polypeptide binding]; other site 1116391003794 Histidine kinase; Region: His_kinase; pfam06580 1116391003795 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391003796 ATP binding site [chemical binding]; other site 1116391003797 Mg2+ binding site [ion binding]; other site 1116391003798 G-X-G motif; other site 1116391003799 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391003800 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391003801 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391003802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003803 dimer interface [polypeptide binding]; other site 1116391003804 conserved gate region; other site 1116391003805 ABC-ATPase subunit interface; other site 1116391003806 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391003807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003808 dimer interface [polypeptide binding]; other site 1116391003809 conserved gate region; other site 1116391003810 ABC-ATPase subunit interface; other site 1116391003811 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1116391003812 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1116391003813 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1116391003814 active site 1116391003815 catalytic residues [active] 1116391003816 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1116391003817 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 1116391003818 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1116391003819 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; cl01762 1116391003820 ethanolamine permease; Region: 2A0305; TIGR00908 1116391003821 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391003822 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 1116391003823 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1116391003824 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1116391003825 active site 1116391003826 putative pectinesterase; Region: PLN02432; cl01911 1116391003827 Pectinesterase; Region: Pectinesterase; pfam01095 1116391003828 threonine synthase; Validated; Region: PRK08197 1116391003829 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1116391003830 homodimer interface [polypeptide binding]; other site 1116391003831 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391003832 catalytic residue [active] 1116391003833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003834 dimer interface [polypeptide binding]; other site 1116391003835 conserved gate region; other site 1116391003836 putative PBP binding loops; other site 1116391003837 ABC-ATPase subunit interface; other site 1116391003838 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1116391003839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391003840 dimer interface [polypeptide binding]; other site 1116391003841 conserved gate region; other site 1116391003842 putative PBP binding loops; other site 1116391003843 ABC-ATPase subunit interface; other site 1116391003844 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1116391003845 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1116391003846 Walker A/P-loop; other site 1116391003847 ATP binding site [chemical binding]; other site 1116391003848 Q-loop/lid; other site 1116391003849 ABC transporter signature motif; other site 1116391003850 Walker B; other site 1116391003851 D-loop; other site 1116391003852 H-loop/switch region; other site 1116391003853 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1116391003854 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391003855 substrate binding pocket [chemical binding]; other site 1116391003856 membrane-bound complex binding site; other site 1116391003857 hinge residues; other site 1116391003858 FAD binding site [chemical binding]; other site 1116391003859 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 1116391003860 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1116391003861 putative active site [active] 1116391003862 putative metal binding site [ion binding]; other site 1116391003863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391003864 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391003865 dimer interface [polypeptide binding]; other site 1116391003866 phosphorylation site [posttranslational modification] 1116391003867 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391003868 ATP binding site [chemical binding]; other site 1116391003869 Mg2+ binding site [ion binding]; other site 1116391003870 G-X-G motif; other site 1116391003871 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1116391003872 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 1116391003873 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1116391003874 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1116391003875 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1116391003876 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1116391003877 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391003878 DNA-binding site [nucleotide binding]; DNA binding site 1116391003879 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1116391003880 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1116391003881 nudix motif; other site 1116391003882 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1116391003883 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1116391003884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391003885 Coenzyme A binding pocket [chemical binding]; other site 1116391003886 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1116391003887 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 1116391003888 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1116391003889 active site 1116391003890 putative substrate binding pocket [chemical binding]; other site 1116391003891 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1116391003892 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1116391003893 Protein of unknown function DUF58; Region: DUF58; pfam01882 1116391003894 MoxR-like ATPases [General function prediction only]; Region: COG0714 1116391003895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391003896 Walker A motif; other site 1116391003897 ATP binding site [chemical binding]; other site 1116391003898 Walker B motif; other site 1116391003899 arginine finger; other site 1116391003900 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1116391003901 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1116391003902 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1116391003903 active site 1116391003904 Zn binding site [ion binding]; other site 1116391003905 S-layer homology domain; Region: SLH; pfam00395 1116391003906 S-layer homology domain; Region: SLH; pfam00395 1116391003907 S-layer homology domain; Region: SLH; pfam00395 1116391003908 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1116391003909 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1116391003910 Bacterial transcriptional regulator; Region: IclR; pfam01614 1116391003911 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1116391003912 classical (c) SDRs; Region: SDR_c; cd05233 1116391003913 NAD(P) binding site [chemical binding]; other site 1116391003914 active site 1116391003915 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1116391003916 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1116391003917 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1116391003918 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1116391003919 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1116391003920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391003921 NAD(P) binding site [chemical binding]; other site 1116391003922 active site 1116391003923 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1116391003924 Amidohydrolase; Region: Amidohydro_4; pfam13147 1116391003925 active site 1116391003926 dimer interface [polypeptide binding]; other site 1116391003927 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1116391003928 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1116391003929 active site 1116391003930 trimer interface [polypeptide binding]; other site 1116391003931 allosteric site; other site 1116391003932 active site lid [active] 1116391003933 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1116391003934 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1116391003935 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1116391003936 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1116391003937 putative active site [active] 1116391003938 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1116391003939 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1116391003940 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1116391003941 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1116391003942 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1116391003943 putative active site [active] 1116391003944 putative NTP binding site [chemical binding]; other site 1116391003945 putative nucleic acid binding site [nucleotide binding]; other site 1116391003946 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 1116391003947 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 1116391003948 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1116391003949 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1116391003950 Walker A/P-loop; other site 1116391003951 ATP binding site [chemical binding]; other site 1116391003952 Q-loop/lid; other site 1116391003953 ABC transporter signature motif; other site 1116391003954 Walker B; other site 1116391003955 D-loop; other site 1116391003956 H-loop/switch region; other site 1116391003957 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1116391003958 FeS assembly protein SufD; Region: sufD; TIGR01981 1116391003959 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1116391003960 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1116391003961 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1116391003962 catalytic residue [active] 1116391003963 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1116391003964 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1116391003965 trimerization site [polypeptide binding]; other site 1116391003966 active site 1116391003967 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1116391003968 FeS assembly protein SufB; Region: sufB; TIGR01980 1116391003969 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1116391003970 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1116391003971 Int/Topo IB signature motif; other site 1116391003972 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1116391003973 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 1116391003974 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 1116391003975 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1116391003976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391003977 non-specific DNA binding site [nucleotide binding]; other site 1116391003978 salt bridge; other site 1116391003979 sequence-specific DNA binding site [nucleotide binding]; other site 1116391003980 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391003981 non-specific DNA binding site [nucleotide binding]; other site 1116391003982 salt bridge; other site 1116391003983 sequence-specific DNA binding site [nucleotide binding]; other site 1116391003984 Domain of unknown function (DUF771); Region: DUF771; cl09962 1116391003985 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391003986 non-specific DNA binding site [nucleotide binding]; other site 1116391003987 salt bridge; other site 1116391003988 sequence-specific DNA binding site [nucleotide binding]; other site 1116391003989 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1116391003990 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1116391003991 RecT family; Region: RecT; cl04285 1116391003992 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 1116391003993 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1116391003994 replicative DNA helicase; Region: DnaB; TIGR00665 1116391003995 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1116391003996 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1116391003997 Walker A motif; other site 1116391003998 ATP binding site [chemical binding]; other site 1116391003999 Walker B motif; other site 1116391004000 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 1116391004001 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1116391004002 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1116391004003 active site 1116391004004 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1116391004005 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1116391004006 Phage-related protein [Function unknown]; Region: COG4695 1116391004007 Phage portal protein; Region: Phage_portal; pfam04860 1116391004008 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 1116391004009 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1116391004010 Phage capsid family; Region: Phage_capsid; pfam05065 1116391004011 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1116391004012 oligomerization interface [polypeptide binding]; other site 1116391004013 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1116391004014 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 1116391004015 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 1116391004016 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 1116391004017 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1116391004018 active site 1116391004019 catalytic triad [active] 1116391004020 oxyanion hole [active] 1116391004021 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391004022 Interdomain contacts; other site 1116391004023 Cytokine receptor motif; other site 1116391004024 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 1116391004025 Phage-related protein [Function unknown]; Region: COG5412 1116391004026 Phage tail protein; Region: Sipho_tail; cl17486 1116391004027 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1116391004028 substrate binding site [chemical binding]; other site 1116391004029 amidase catalytic site [active] 1116391004030 Zn binding residues [ion binding]; other site 1116391004031 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1116391004032 Cupin; Region: Cupin_1; smart00835 1116391004033 Transmembrane protein; Region: Macoilin; pfam09726 1116391004034 Helix-turn-helix domain; Region: HTH_36; pfam13730 1116391004035 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1116391004036 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1116391004037 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1116391004038 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1116391004039 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1116391004040 K+-transporting ATPase, c chain; Region: KdpC; cl00944 1116391004041 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1116391004042 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1116391004043 Ligand Binding Site [chemical binding]; other site 1116391004044 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1116391004045 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1116391004046 Ligand Binding Site [chemical binding]; other site 1116391004047 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1116391004048 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1116391004049 GAF domain; Region: GAF_3; pfam13492 1116391004050 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391004051 dimer interface [polypeptide binding]; other site 1116391004052 phosphorylation site [posttranslational modification] 1116391004053 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391004054 ATP binding site [chemical binding]; other site 1116391004055 Mg2+ binding site [ion binding]; other site 1116391004056 G-X-G motif; other site 1116391004057 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1116391004058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391004059 active site 1116391004060 phosphorylation site [posttranslational modification] 1116391004061 intermolecular recognition site; other site 1116391004062 dimerization interface [polypeptide binding]; other site 1116391004063 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391004064 DNA binding site [nucleotide binding] 1116391004065 Predicted transcriptional regulators [Transcription]; Region: COG1695 1116391004066 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1116391004067 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 1116391004068 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 1116391004069 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1116391004070 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391004071 Walker A/P-loop; other site 1116391004072 ATP binding site [chemical binding]; other site 1116391004073 Q-loop/lid; other site 1116391004074 ABC transporter signature motif; other site 1116391004075 Walker B; other site 1116391004076 D-loop; other site 1116391004077 H-loop/switch region; other site 1116391004078 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1116391004079 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1116391004080 MULE transposase domain; Region: MULE; pfam10551 1116391004081 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1116391004082 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1116391004083 DNA binding residues [nucleotide binding] 1116391004084 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391004085 NmrA-like family; Region: NmrA; pfam05368 1116391004086 NAD(P) binding site [chemical binding]; other site 1116391004087 active site 1116391004088 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1116391004089 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391004090 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391004091 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391004092 NAD(P) binding site [chemical binding]; other site 1116391004093 active site 1116391004094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1116391004095 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1116391004096 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1116391004097 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391004098 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391004099 Transposase; Region: HTH_Tnp_1; cl17663 1116391004100 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391004101 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391004102 HTH-like domain; Region: HTH_21; pfam13276 1116391004103 Integrase core domain; Region: rve; pfam00665 1116391004104 Integrase core domain; Region: rve_2; pfam13333 1116391004105 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1116391004106 classical (c) SDRs; Region: SDR_c; cd05233 1116391004107 NAD(P) binding site [chemical binding]; other site 1116391004108 active site 1116391004109 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1116391004110 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1116391004111 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1116391004112 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1116391004113 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1116391004114 Aspartase; Region: Aspartase; cd01357 1116391004115 active sites [active] 1116391004116 tetramer interface [polypeptide binding]; other site 1116391004117 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1116391004118 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1116391004119 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1116391004120 active site 1116391004121 homotetramer interface [polypeptide binding]; other site 1116391004122 homodimer interface [polypeptide binding]; other site 1116391004123 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1116391004124 dimerization interface [polypeptide binding]; other site 1116391004125 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 1116391004126 mannose binding site [chemical binding]; other site 1116391004127 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391004128 MarR family; Region: MarR; pfam01047 1116391004129 active site 1116391004130 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1116391004131 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1116391004132 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1116391004133 NAD binding site [chemical binding]; other site 1116391004134 substrate binding site [chemical binding]; other site 1116391004135 putative active site [active] 1116391004136 hypothetical protein; Validated; Region: PRK07581 1116391004137 Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021 1116391004138 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391004139 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391004140 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391004141 dimerization interface [polypeptide binding]; other site 1116391004142 hypothetical protein; Provisional; Region: PRK06184 1116391004143 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1116391004144 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1116391004145 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1116391004146 conserved cys residue [active] 1116391004147 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1116391004148 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1116391004149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391004150 putative substrate translocation pore; other site 1116391004151 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1116391004152 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1116391004153 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1116391004154 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1116391004155 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 1116391004156 putative hydrophobic ligand binding site [chemical binding]; other site 1116391004157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391004158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391004159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391004160 dimerization interface [polypeptide binding]; other site 1116391004161 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1116391004162 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1116391004163 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391004164 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1116391004165 NlpC/P60 family; Region: NLPC_P60; pfam00877 1116391004166 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1116391004167 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1116391004168 Zn2+ binding site [ion binding]; other site 1116391004169 Mg2+ binding site [ion binding]; other site 1116391004170 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1116391004171 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1116391004172 ATP binding site [chemical binding]; other site 1116391004173 substrate interface [chemical binding]; other site 1116391004174 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1116391004175 MoaE interaction surface [polypeptide binding]; other site 1116391004176 MoeB interaction surface [polypeptide binding]; other site 1116391004177 thiocarboxylated glycine; other site 1116391004178 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1116391004179 MoaE homodimer interface [polypeptide binding]; other site 1116391004180 MoaD interaction [polypeptide binding]; other site 1116391004181 active site residues [active] 1116391004182 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1116391004183 Moco binding site; other site 1116391004184 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1116391004185 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391004186 active site 1116391004187 metal binding site [ion binding]; metal-binding site 1116391004188 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1116391004189 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1116391004190 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391004191 FeS/SAM binding site; other site 1116391004192 YfkB-like domain; Region: YfkB; pfam08756 1116391004193 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1116391004194 Domain of unknown function DUF21; Region: DUF21; pfam01595 1116391004195 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1116391004196 Transporter associated domain; Region: CorC_HlyC; smart01091 1116391004197 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1116391004198 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1116391004199 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1116391004200 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1116391004201 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1116391004202 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 1116391004203 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1116391004204 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1116391004205 NlpC/P60 family; Region: NLPC_P60; pfam00877 1116391004206 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1116391004207 CotJB protein; Region: CotJB; pfam12652 1116391004208 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1116391004209 dinuclear metal binding motif [ion binding]; other site 1116391004210 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391004211 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391004212 Domain of unknown function (DUF4258); Region: DUF4258; pfam14076 1116391004213 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1116391004214 dinuclear metal binding motif [ion binding]; other site 1116391004215 Protein of unknown function (DUF975); Region: DUF975; cl10504 1116391004216 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1116391004217 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391004218 motif II; other site 1116391004219 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1116391004220 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1116391004221 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1116391004222 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1116391004223 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1116391004224 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1116391004225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391004226 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1116391004227 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1116391004228 hypothetical protein; Provisional; Region: PRK07236 1116391004229 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1116391004230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391004231 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391004232 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391004233 MarR family; Region: MarR_2; pfam12802 1116391004234 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1116391004235 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1116391004236 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1116391004237 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1116391004238 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1116391004239 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1116391004240 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391004241 DNA-binding site [nucleotide binding]; DNA binding site 1116391004242 DRTGG domain; Region: DRTGG; pfam07085 1116391004243 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1116391004244 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1116391004245 active site 2 [active] 1116391004246 active site 1 [active] 1116391004247 YtpI-like protein; Region: YtpI; pfam14007 1116391004248 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1116391004249 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 1116391004250 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1116391004251 active site 1116391004252 PHP Thumb interface [polypeptide binding]; other site 1116391004253 metal binding site [ion binding]; metal-binding site 1116391004254 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1116391004255 generic binding surface II; other site 1116391004256 generic binding surface I; other site 1116391004257 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1116391004258 tetramer interfaces [polypeptide binding]; other site 1116391004259 binuclear metal-binding site [ion binding]; other site 1116391004260 Flavodoxin domain; Region: Flavodoxin_5; cl17428 1116391004261 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1116391004262 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 1116391004263 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1116391004264 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1116391004265 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1116391004266 pyruvate kinase; Provisional; Region: PRK06354 1116391004267 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1116391004268 domain interfaces; other site 1116391004269 active site 1116391004270 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 1116391004271 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1116391004272 active site 1116391004273 polyphosphate kinase; Provisional; Region: PRK05443 1116391004274 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1116391004275 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1116391004276 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1116391004277 putative domain interface [polypeptide binding]; other site 1116391004278 putative active site [active] 1116391004279 catalytic site [active] 1116391004280 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1116391004281 putative domain interface [polypeptide binding]; other site 1116391004282 putative active site [active] 1116391004283 catalytic site [active] 1116391004284 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1116391004285 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1116391004286 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 1116391004287 dimer interface [polypeptide binding]; other site 1116391004288 Citrate synthase; Region: Citrate_synt; pfam00285 1116391004289 active site 1116391004290 citrylCoA binding site [chemical binding]; other site 1116391004291 oxalacetate/citrate binding site [chemical binding]; other site 1116391004292 coenzyme A binding site [chemical binding]; other site 1116391004293 catalytic triad [active] 1116391004294 isocitrate dehydrogenase; Validated; Region: PRK06451 1116391004295 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1116391004296 malate dehydrogenase; Reviewed; Region: PRK06223 1116391004297 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1116391004298 NAD(P) binding site [chemical binding]; other site 1116391004299 dimer interface [polypeptide binding]; other site 1116391004300 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1116391004301 substrate binding site [chemical binding]; other site 1116391004302 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1116391004303 5'-nucleotidase; Provisional; Region: PRK03826 1116391004304 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 1116391004305 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1116391004306 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1116391004307 Sodium Bile acid symporter family; Region: SBF; cl17470 1116391004308 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1116391004309 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391004310 dimerization interface [polypeptide binding]; other site 1116391004311 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391004312 putative active site [active] 1116391004313 heme pocket [chemical binding]; other site 1116391004314 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391004315 dimer interface [polypeptide binding]; other site 1116391004316 phosphorylation site [posttranslational modification] 1116391004317 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391004318 ATP binding site [chemical binding]; other site 1116391004319 Mg2+ binding site [ion binding]; other site 1116391004320 G-X-G motif; other site 1116391004321 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391004322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391004323 active site 1116391004324 phosphorylation site [posttranslational modification] 1116391004325 intermolecular recognition site; other site 1116391004326 dimerization interface [polypeptide binding]; other site 1116391004327 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391004328 DNA binding site [nucleotide binding] 1116391004329 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391004330 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391004331 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391004332 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391004333 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391004334 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391004335 CHASE3 domain; Region: CHASE3; cl05000 1116391004336 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391004337 dimerization interface [polypeptide binding]; other site 1116391004338 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391004339 dimer interface [polypeptide binding]; other site 1116391004340 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1116391004341 putative CheW interface [polypeptide binding]; other site 1116391004342 PBP superfamily domain; Region: PBP_like_2; cl17296 1116391004343 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1116391004344 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1116391004345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391004346 dimer interface [polypeptide binding]; other site 1116391004347 conserved gate region; other site 1116391004348 putative PBP binding loops; other site 1116391004349 ABC-ATPase subunit interface; other site 1116391004350 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1116391004351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391004352 dimer interface [polypeptide binding]; other site 1116391004353 conserved gate region; other site 1116391004354 putative PBP binding loops; other site 1116391004355 ABC-ATPase subunit interface; other site 1116391004356 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1116391004357 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1116391004358 Walker A/P-loop; other site 1116391004359 ATP binding site [chemical binding]; other site 1116391004360 Q-loop/lid; other site 1116391004361 ABC transporter signature motif; other site 1116391004362 Walker B; other site 1116391004363 D-loop; other site 1116391004364 H-loop/switch region; other site 1116391004365 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1116391004366 PhoU domain; Region: PhoU; pfam01895 1116391004367 PhoU domain; Region: PhoU; pfam01895 1116391004368 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 1116391004369 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391004370 motif II; other site 1116391004371 DNA polymerase I; Provisional; Region: PRK05755 1116391004372 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1116391004373 active site 1116391004374 metal binding site 1 [ion binding]; metal-binding site 1116391004375 putative 5' ssDNA interaction site; other site 1116391004376 metal binding site 3; metal-binding site 1116391004377 metal binding site 2 [ion binding]; metal-binding site 1116391004378 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1116391004379 putative DNA binding site [nucleotide binding]; other site 1116391004380 putative metal binding site [ion binding]; other site 1116391004381 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1116391004382 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1116391004383 active site 1116391004384 DNA binding site [nucleotide binding] 1116391004385 catalytic site [active] 1116391004386 formamidopyrimidine-DNA glycosylase; Provisional; Region: PRK13945 1116391004387 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1116391004388 DNA binding site [nucleotide binding] 1116391004389 catalytic residue [active] 1116391004390 H2TH interface [polypeptide binding]; other site 1116391004391 putative catalytic residues [active] 1116391004392 turnover-facilitating residue; other site 1116391004393 intercalation triad [nucleotide binding]; other site 1116391004394 8OG recognition residue [nucleotide binding]; other site 1116391004395 putative reading head residues; other site 1116391004396 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1116391004397 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1116391004398 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1116391004399 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1116391004400 CoA-binding site [chemical binding]; other site 1116391004401 ATP-binding [chemical binding]; other site 1116391004402 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1116391004403 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1116391004404 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1116391004405 catalytic residue [active] 1116391004406 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1116391004407 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1116391004408 ATP cone domain; Region: ATP-cone; pfam03477 1116391004409 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 1116391004410 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1116391004411 Predicted flavoprotein [General function prediction only]; Region: COG0431 1116391004412 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1116391004413 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391004414 dimerization interface [polypeptide binding]; other site 1116391004415 putative DNA binding site [nucleotide binding]; other site 1116391004416 Winged helix-turn helix; Region: HTH_29; pfam13551 1116391004417 putative Zn2+ binding site [ion binding]; other site 1116391004418 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 1116391004419 putative hydrophobic ligand binding site [chemical binding]; other site 1116391004420 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391004421 MarR family; Region: MarR_2; pfam12802 1116391004422 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1116391004423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391004424 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1116391004425 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 1116391004426 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1116391004427 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1116391004428 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 1116391004429 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391004430 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1116391004431 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 1116391004432 putative NAD(P) binding site [chemical binding]; other site 1116391004433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391004434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391004435 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1116391004436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391004437 Coenzyme A binding pocket [chemical binding]; other site 1116391004438 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391004439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391004440 active site 1116391004441 phosphorylation site [posttranslational modification] 1116391004442 intermolecular recognition site; other site 1116391004443 dimerization interface [polypeptide binding]; other site 1116391004444 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391004445 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391004446 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391004447 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391004448 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391004449 dimerization interface [polypeptide binding]; other site 1116391004450 Histidine kinase; Region: His_kinase; pfam06580 1116391004451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391004452 ATP binding site [chemical binding]; other site 1116391004453 Mg2+ binding site [ion binding]; other site 1116391004454 G-X-G motif; other site 1116391004455 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391004456 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391004457 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391004458 dimer interface [polypeptide binding]; other site 1116391004459 conserved gate region; other site 1116391004460 putative PBP binding loops; other site 1116391004461 ABC-ATPase subunit interface; other site 1116391004462 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391004463 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1116391004464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391004465 dimer interface [polypeptide binding]; other site 1116391004466 conserved gate region; other site 1116391004467 putative PBP binding loops; other site 1116391004468 ABC-ATPase subunit interface; other site 1116391004469 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1116391004470 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 1116391004471 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1116391004472 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1116391004473 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1116391004474 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1116391004475 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 1116391004476 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391004477 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1116391004478 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391004479 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1116391004480 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391004481 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391004482 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 1116391004483 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1116391004484 active site residue [active] 1116391004485 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1116391004486 putative homodimer interface [polypeptide binding]; other site 1116391004487 putative homotetramer interface [polypeptide binding]; other site 1116391004488 putative metal binding site [ion binding]; other site 1116391004489 putative homodimer-homodimer interface [polypeptide binding]; other site 1116391004490 putative allosteric switch controlling residues; other site 1116391004491 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1116391004492 active site residue [active] 1116391004493 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1116391004494 CPxP motif; other site 1116391004495 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1116391004496 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1116391004497 CPxP motif; other site 1116391004498 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1116391004499 active site residue [active] 1116391004500 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1116391004501 active site residue [active] 1116391004502 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1116391004503 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1116391004504 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391004505 Interdomain contacts; other site 1116391004506 Cytokine receptor motif; other site 1116391004507 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391004508 Interdomain contacts; other site 1116391004509 Cytokine receptor motif; other site 1116391004510 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 1116391004511 dockerin binding interface; other site 1116391004512 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1116391004513 Cation efflux family; Region: Cation_efflux; pfam01545 1116391004514 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391004515 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1116391004516 nudix motif; other site 1116391004517 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391004518 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391004519 putative substrate translocation pore; other site 1116391004520 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1116391004521 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1116391004522 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1116391004523 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1116391004524 NAD(P) binding site [chemical binding]; other site 1116391004525 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1116391004526 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1116391004527 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1116391004528 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1116391004529 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1116391004530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1116391004531 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1116391004532 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1116391004533 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1116391004534 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1116391004535 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1116391004536 Predicted transcriptional regulator [Transcription]; Region: COG2378 1116391004537 HTH domain; Region: HTH_11; pfam08279 1116391004538 WYL domain; Region: WYL; pfam13280 1116391004539 short chain dehydrogenase; Provisional; Region: PRK12939 1116391004540 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1116391004541 NADP binding site [chemical binding]; other site 1116391004542 homodimer interface [polypeptide binding]; other site 1116391004543 active site 1116391004544 substrate binding site [chemical binding]; other site 1116391004545 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 1116391004546 putative dimer interface [polypeptide binding]; other site 1116391004547 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391004548 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1116391004549 active site 1 [active] 1116391004550 dimer interface [polypeptide binding]; other site 1116391004551 hexamer interface [polypeptide binding]; other site 1116391004552 active site 2 [active] 1116391004553 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1116391004554 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391004555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391004556 short chain dehydrogenase; Validated; Region: PRK08264 1116391004557 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391004558 NAD(P) binding site [chemical binding]; other site 1116391004559 active site 1116391004560 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1116391004561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391004562 NAD(P) binding site [chemical binding]; other site 1116391004563 active site 1116391004564 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1116391004565 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1116391004566 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1116391004567 putative NAD(P) binding site [chemical binding]; other site 1116391004568 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391004569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391004570 putative substrate translocation pore; other site 1116391004571 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1116391004572 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391004573 S-adenosylmethionine binding site [chemical binding]; other site 1116391004574 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391004575 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1116391004576 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1116391004577 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 1116391004578 Histidine kinase; Region: HisKA_3; pfam07730 1116391004579 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1116391004580 ATP binding site [chemical binding]; other site 1116391004581 Mg2+ binding site [ion binding]; other site 1116391004582 G-X-G motif; other site 1116391004583 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391004584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391004585 active site 1116391004586 phosphorylation site [posttranslational modification] 1116391004587 intermolecular recognition site; other site 1116391004588 dimerization interface [polypeptide binding]; other site 1116391004589 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391004590 DNA binding residues [nucleotide binding] 1116391004591 dimerization interface [polypeptide binding]; other site 1116391004592 DoxX-like family; Region: DoxX_2; pfam13564 1116391004593 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391004594 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1116391004595 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391004596 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391004597 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391004598 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391004599 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391004600 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1116391004601 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1116391004602 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1116391004603 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1116391004604 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1116391004605 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1116391004606 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1116391004607 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1116391004608 regulatory protein interface [polypeptide binding]; other site 1116391004609 active site 1116391004610 regulatory phosphorylation site [posttranslational modification]; other site 1116391004611 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1116391004612 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1116391004613 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1116391004614 Transposase domain (DUF772); Region: DUF772; pfam05598 1116391004615 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1116391004616 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1116391004617 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1116391004618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391004619 putative substrate translocation pore; other site 1116391004620 Cache domain; Region: Cache_1; pfam02743 1116391004621 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391004622 Histidine kinase; Region: His_kinase; pfam06580 1116391004623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391004624 ATP binding site [chemical binding]; other site 1116391004625 Mg2+ binding site [ion binding]; other site 1116391004626 G-X-G motif; other site 1116391004627 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391004628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391004629 active site 1116391004630 phosphorylation site [posttranslational modification] 1116391004631 intermolecular recognition site; other site 1116391004632 dimerization interface [polypeptide binding]; other site 1116391004633 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391004634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391004635 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 1116391004636 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1116391004637 NodB motif; other site 1116391004638 putative active site [active] 1116391004639 putative catalytic site [active] 1116391004640 putative Zn binding site [ion binding]; other site 1116391004641 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391004642 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391004643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391004644 dimer interface [polypeptide binding]; other site 1116391004645 conserved gate region; other site 1116391004646 putative PBP binding loops; other site 1116391004647 ABC-ATPase subunit interface; other site 1116391004648 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391004649 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391004650 dimer interface [polypeptide binding]; other site 1116391004651 conserved gate region; other site 1116391004652 putative PBP binding loops; other site 1116391004653 ABC-ATPase subunit interface; other site 1116391004654 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 1116391004655 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1116391004656 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1116391004657 heme-binding site [chemical binding]; other site 1116391004658 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1116391004659 FAD binding pocket [chemical binding]; other site 1116391004660 FAD binding motif [chemical binding]; other site 1116391004661 phosphate binding motif [ion binding]; other site 1116391004662 beta-alpha-beta structure motif; other site 1116391004663 NAD binding pocket [chemical binding]; other site 1116391004664 Heme binding pocket [chemical binding]; other site 1116391004665 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1116391004666 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1116391004667 ligand binding site [chemical binding]; other site 1116391004668 flexible hinge region; other site 1116391004669 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1116391004670 non-specific DNA interactions [nucleotide binding]; other site 1116391004671 DNA binding site [nucleotide binding] 1116391004672 sequence specific DNA binding site [nucleotide binding]; other site 1116391004673 putative cAMP binding site [chemical binding]; other site 1116391004674 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391004675 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391004676 Pyruvate formate lyase 1; Region: PFL1; cd01678 1116391004677 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1116391004678 coenzyme A binding site [chemical binding]; other site 1116391004679 active site 1116391004680 catalytic residues [active] 1116391004681 glycine loop; other site 1116391004682 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1116391004683 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391004684 FeS/SAM binding site; other site 1116391004685 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1116391004686 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 1116391004687 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1116391004688 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 1116391004689 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1116391004690 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1116391004691 [4Fe-4S] binding site [ion binding]; other site 1116391004692 molybdopterin cofactor binding site; other site 1116391004693 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1116391004694 molybdopterin cofactor binding site; other site 1116391004695 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1116391004696 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1116391004697 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1116391004698 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1116391004699 iron-sulfur cluster [ion binding]; other site 1116391004700 [2Fe-2S] cluster binding site [ion binding]; other site 1116391004701 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 1116391004702 putative hydrophobic ligand binding site [chemical binding]; other site 1116391004703 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1116391004704 putative hydrophobic ligand binding site [chemical binding]; other site 1116391004705 hydroxylamine reductase; Provisional; Region: PRK12310 1116391004706 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1116391004707 ACS interaction site; other site 1116391004708 CODH interaction site; other site 1116391004709 metal cluster binding site [ion binding]; other site 1116391004710 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1116391004711 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1116391004712 ligand binding site [chemical binding]; other site 1116391004713 flexible hinge region; other site 1116391004714 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1116391004715 non-specific DNA interactions [nucleotide binding]; other site 1116391004716 DNA binding site [nucleotide binding] 1116391004717 sequence specific DNA binding site [nucleotide binding]; other site 1116391004718 putative cAMP binding site [chemical binding]; other site 1116391004719 GAF domain; Region: GAF; pfam01590 1116391004720 GAF domain; Region: GAF_2; pfam13185 1116391004721 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391004722 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391004723 active site 1116391004724 phosphorylation site [posttranslational modification] 1116391004725 intermolecular recognition site; other site 1116391004726 dimerization interface [polypeptide binding]; other site 1116391004727 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391004728 DNA binding residues [nucleotide binding] 1116391004729 dimerization interface [polypeptide binding]; other site 1116391004730 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391004731 PAS domain; Region: PAS_9; pfam13426 1116391004732 putative active site [active] 1116391004733 heme pocket [chemical binding]; other site 1116391004734 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1116391004735 Histidine kinase; Region: HisKA_3; pfam07730 1116391004736 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391004737 ATP binding site [chemical binding]; other site 1116391004738 Mg2+ binding site [ion binding]; other site 1116391004739 G-X-G motif; other site 1116391004740 Hemerythrin family; Region: Hemerythrin-like; cl15774 1116391004741 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1116391004742 30S subunit binding site; other site 1116391004743 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1116391004744 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1116391004745 putative catalytic cysteine [active] 1116391004746 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1116391004747 putative active site [active] 1116391004748 metal binding site [ion binding]; metal-binding site 1116391004749 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1116391004750 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1116391004751 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1116391004752 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1116391004753 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1116391004754 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1116391004755 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1116391004756 iron-sulfur cluster [ion binding]; other site 1116391004757 [2Fe-2S] cluster binding site [ion binding]; other site 1116391004758 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1116391004759 GTP binding site; other site 1116391004760 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1116391004761 dimerization interface [polypeptide binding]; other site 1116391004762 active site 1116391004763 PAS fold; Region: PAS_4; pfam08448 1116391004764 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1116391004765 putative active site [active] 1116391004766 heme pocket [chemical binding]; other site 1116391004767 PAS domain S-box; Region: sensory_box; TIGR00229 1116391004768 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391004769 putative active site [active] 1116391004770 heme pocket [chemical binding]; other site 1116391004771 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391004772 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391004773 metal binding site [ion binding]; metal-binding site 1116391004774 active site 1116391004775 I-site; other site 1116391004776 NlpC/P60 family; Region: NLPC_P60; pfam00877 1116391004777 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 1116391004778 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1116391004779 active sites [active] 1116391004780 tetramer interface [polypeptide binding]; other site 1116391004781 urocanate hydratase; Provisional; Region: PRK05414 1116391004782 imidazolonepropionase; Validated; Region: PRK09356 1116391004783 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1116391004784 active site 1116391004785 allantoate amidohydrolase; Reviewed; Region: PRK09290 1116391004786 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1116391004787 active site 1116391004788 metal binding site [ion binding]; metal-binding site 1116391004789 dimer interface [polypeptide binding]; other site 1116391004790 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1116391004791 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 1116391004792 active site 1116391004793 putative substrate binding pocket [chemical binding]; other site 1116391004794 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; pfam01373 1116391004795 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 1116391004796 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 1116391004797 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1116391004798 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1116391004799 active site 1116391004800 catalytic site [active] 1116391004801 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1116391004802 EamA-like transporter family; Region: EamA; pfam00892 1116391004803 Amino acid permease; Region: AA_permease_2; pfam13520 1116391004804 K+ potassium transporter; Region: K_trans; cl15781 1116391004805 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; pfam01373 1116391004806 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 1116391004807 starch-binding site 2 [chemical binding]; other site 1116391004808 starch-binding site 1 [chemical binding]; other site 1116391004809 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 1116391004810 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1116391004811 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 1116391004812 putative ligand binding site [chemical binding]; other site 1116391004813 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1116391004814 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1116391004815 Walker A/P-loop; other site 1116391004816 ATP binding site [chemical binding]; other site 1116391004817 Q-loop/lid; other site 1116391004818 ABC transporter signature motif; other site 1116391004819 Walker B; other site 1116391004820 D-loop; other site 1116391004821 H-loop/switch region; other site 1116391004822 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1116391004823 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391004824 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1116391004825 TM-ABC transporter signature motif; other site 1116391004826 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1116391004827 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391004828 TM-ABC transporter signature motif; other site 1116391004829 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1116391004830 nucleoside/Zn binding site; other site 1116391004831 dimer interface [polypeptide binding]; other site 1116391004832 catalytic motif [active] 1116391004833 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391004834 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391004835 dimer interface [polypeptide binding]; other site 1116391004836 putative CheW interface [polypeptide binding]; other site 1116391004837 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391004838 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391004839 DNA binding site [nucleotide binding] 1116391004840 domain linker motif; other site 1116391004841 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1116391004842 dimerization interface [polypeptide binding]; other site 1116391004843 ligand binding site [chemical binding]; other site 1116391004844 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1116391004845 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1116391004846 putative substrate binding site [chemical binding]; other site 1116391004847 putative ATP binding site [chemical binding]; other site 1116391004848 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1116391004849 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1116391004850 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 1116391004851 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1116391004852 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391004853 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391004854 active site 1116391004855 phosphorylation site [posttranslational modification] 1116391004856 intermolecular recognition site; other site 1116391004857 dimerization interface [polypeptide binding]; other site 1116391004858 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391004859 DNA binding site [nucleotide binding] 1116391004860 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391004861 dimerization interface [polypeptide binding]; other site 1116391004862 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391004863 dimer interface [polypeptide binding]; other site 1116391004864 phosphorylation site [posttranslational modification] 1116391004865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391004866 ATP binding site [chemical binding]; other site 1116391004867 Mg2+ binding site [ion binding]; other site 1116391004868 G-X-G motif; other site 1116391004869 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1116391004870 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1116391004871 S-layer homology domain; Region: SLH; pfam00395 1116391004872 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1116391004873 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1116391004874 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 1116391004875 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 1116391004876 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391004877 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391004878 metal binding site [ion binding]; metal-binding site 1116391004879 active site 1116391004880 I-site; other site 1116391004881 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1116391004882 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391004883 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1116391004884 Protein export membrane protein; Region: SecD_SecF; cl14618 1116391004885 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1116391004886 HlyD family secretion protein; Region: HlyD_3; pfam13437 1116391004887 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1116391004888 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1116391004889 putative active site [active] 1116391004890 putative metal binding site [ion binding]; other site 1116391004891 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1116391004892 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 1116391004893 VanW like protein; Region: VanW; pfam04294 1116391004894 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1116391004895 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1116391004896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391004897 Coenzyme A binding pocket [chemical binding]; other site 1116391004898 Cache domain; Region: Cache_1; pfam02743 1116391004899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391004900 dimerization interface [polypeptide binding]; other site 1116391004901 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391004902 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391004903 dimer interface [polypeptide binding]; other site 1116391004904 putative CheW interface [polypeptide binding]; other site 1116391004905 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1116391004906 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1116391004907 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1116391004908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391004909 ATP binding site [chemical binding]; other site 1116391004910 ABC transporter; Region: ABC_tran; pfam00005 1116391004911 Q-loop/lid; other site 1116391004912 ABC transporter signature motif; other site 1116391004913 Walker B; other site 1116391004914 D-loop; other site 1116391004915 H-loop/switch region; other site 1116391004916 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1116391004917 DinB family; Region: DinB; cl17821 1116391004918 DinB superfamily; Region: DinB_2; pfam12867 1116391004919 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1116391004920 NlpC/P60 family; Region: NLPC_P60; pfam00877 1116391004921 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1116391004922 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391004923 DNA-binding site [nucleotide binding]; DNA binding site 1116391004924 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391004925 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1116391004926 putative ligand binding site [chemical binding]; other site 1116391004927 putative dimerization interface [polypeptide binding]; other site 1116391004928 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1116391004929 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1116391004930 intersubunit interface [polypeptide binding]; other site 1116391004931 active site 1116391004932 Zn2+ binding site [ion binding]; other site 1116391004933 ribulokinase; Provisional; Region: PRK04123 1116391004934 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1116391004935 N- and C-terminal domain interface [polypeptide binding]; other site 1116391004936 active site 1116391004937 MgATP binding site [chemical binding]; other site 1116391004938 catalytic site [active] 1116391004939 metal binding site [ion binding]; metal-binding site 1116391004940 carbohydrate binding site [chemical binding]; other site 1116391004941 homodimer interface [polypeptide binding]; other site 1116391004942 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1116391004943 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1116391004944 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 1116391004945 nucleotide binding site/active site [active] 1116391004946 HIT family signature motif; other site 1116391004947 catalytic residue [active] 1116391004948 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391004949 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1116391004950 FeS/SAM binding site; other site 1116391004951 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1116391004952 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391004953 MarR family; Region: MarR; pfam01047 1116391004954 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1116391004955 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1116391004956 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1116391004957 nucleotide binding site [chemical binding]; other site 1116391004958 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1116391004959 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1116391004960 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1116391004961 binding surface 1116391004962 TPR motif; other site 1116391004963 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1116391004964 binding surface 1116391004965 TPR motif; other site 1116391004966 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1116391004967 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1116391004968 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1116391004969 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1116391004970 dimer interface [polypeptide binding]; other site 1116391004971 substrate binding site [chemical binding]; other site 1116391004972 ATP binding site [chemical binding]; other site 1116391004973 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1116391004974 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391004975 putative DNA binding site [nucleotide binding]; other site 1116391004976 putative Zn2+ binding site [ion binding]; other site 1116391004977 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1116391004978 active site 1116391004979 catalytic residues [active] 1116391004980 metal binding site [ion binding]; metal-binding site 1116391004981 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1116391004982 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391004983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391004984 active site 1116391004985 phosphorylation site [posttranslational modification] 1116391004986 intermolecular recognition site; other site 1116391004987 dimerization interface [polypeptide binding]; other site 1116391004988 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391004989 DNA binding site [nucleotide binding] 1116391004990 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391004991 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391004992 dimerization interface [polypeptide binding]; other site 1116391004993 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391004994 dimer interface [polypeptide binding]; other site 1116391004995 phosphorylation site [posttranslational modification] 1116391004996 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391004997 ATP binding site [chemical binding]; other site 1116391004998 Mg2+ binding site [ion binding]; other site 1116391004999 G-X-G motif; other site 1116391005000 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1116391005001 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1116391005002 active site 1116391005003 intersubunit interface [polypeptide binding]; other site 1116391005004 catalytic residue [active] 1116391005005 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1116391005006 YtxH-like protein; Region: YtxH; pfam12732 1116391005007 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1116391005008 LytTr DNA-binding domain; Region: LytTR; cl04498 1116391005009 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391005010 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391005011 metal binding site [ion binding]; metal-binding site 1116391005012 active site 1116391005013 I-site; other site 1116391005014 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1116391005015 Staphylococcal AgrD protein; Region: AgrD; cl05477 1116391005016 Accessory gene regulator B; Region: AgrB; cl01873 1116391005017 CAAX protease self-immunity; Region: Abi; pfam02517 1116391005018 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391005019 non-specific DNA binding site [nucleotide binding]; other site 1116391005020 salt bridge; other site 1116391005021 sequence-specific DNA binding site [nucleotide binding]; other site 1116391005022 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 1116391005023 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1116391005024 Glucose dehydrogenase; Region: glucose_DH; cd08230 1116391005025 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1116391005026 NADP binding site [chemical binding]; other site 1116391005027 catalytic Zn binding site [ion binding]; other site 1116391005028 structural Zn binding site [ion binding]; other site 1116391005029 dimer interface [polypeptide binding]; other site 1116391005030 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 1116391005031 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 1116391005032 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1116391005033 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1116391005034 S-layer homology domain; Region: SLH; pfam00395 1116391005035 S-layer homology domain; Region: SLH; pfam00395 1116391005036 Family description; Region: VCBS; pfam13517 1116391005037 Family description; Region: VCBS; pfam13517 1116391005038 Family description; Region: VCBS; pfam13517 1116391005039 Family description; Region: VCBS; pfam13517 1116391005040 Family description; Region: VCBS; pfam13517 1116391005041 Family description; Region: VCBS; pfam13517 1116391005042 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 1116391005043 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391005044 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005045 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391005046 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005047 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1116391005048 alpha-galactosidase; Provisional; Region: PRK15076 1116391005049 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1116391005050 NAD binding site [chemical binding]; other site 1116391005051 sugar binding site [chemical binding]; other site 1116391005052 divalent metal binding site [ion binding]; other site 1116391005053 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1116391005054 dimer interface [polypeptide binding]; other site 1116391005055 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1116391005056 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1116391005057 NodB motif; other site 1116391005058 active site 1116391005059 catalytic site [active] 1116391005060 Cd binding site [ion binding]; other site 1116391005061 glutamate racemase; Provisional; Region: PRK00865 1116391005062 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391005063 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1116391005064 putative active site [active] 1116391005065 Zn binding site [ion binding]; other site 1116391005066 Domain of unknown function (DUF377); Region: DUF377; pfam04041 1116391005067 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1116391005068 active site 1116391005069 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391005070 Helix-turn-helix domain; Region: HTH_18; pfam12833 1116391005071 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005072 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1116391005073 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1116391005074 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391005075 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391005076 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1116391005077 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1116391005078 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391005079 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1116391005080 SdiA-regulated; Region: SdiA-regulated; cd09971 1116391005081 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1116391005082 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1116391005083 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1116391005084 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1116391005085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1116391005086 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1116391005087 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391005088 S-adenosylmethionine binding site [chemical binding]; other site 1116391005089 DinB family; Region: DinB; cl17821 1116391005090 DinB superfamily; Region: DinB_2; pfam12867 1116391005091 drug efflux system protein MdtG; Provisional; Region: PRK09874 1116391005092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391005093 putative substrate translocation pore; other site 1116391005094 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1116391005095 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391005096 active site 1116391005097 metal binding site [ion binding]; metal-binding site 1116391005098 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1116391005099 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1116391005100 putative active site [active] 1116391005101 putative metal binding site [ion binding]; other site 1116391005102 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1116391005103 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1116391005104 Integral membrane protein DUF92; Region: DUF92; pfam01940 1116391005105 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1116391005106 oligoendopeptidase F; Region: pepF; TIGR00181 1116391005107 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1116391005108 active site 1116391005109 Zn binding site [ion binding]; other site 1116391005110 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1116391005111 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1116391005112 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1116391005113 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1116391005114 DNA-binding site [nucleotide binding]; DNA binding site 1116391005115 RNA-binding motif; other site 1116391005116 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 1116391005117 FMN binding site [chemical binding]; other site 1116391005118 dimer interface [polypeptide binding]; other site 1116391005119 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1116391005120 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1116391005121 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1116391005122 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1116391005123 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1116391005124 HlyD family secretion protein; Region: HlyD_3; pfam13437 1116391005125 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1116391005126 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1116391005127 FtsX-like permease family; Region: FtsX; pfam02687 1116391005128 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1116391005129 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1116391005130 Walker A/P-loop; other site 1116391005131 ATP binding site [chemical binding]; other site 1116391005132 Q-loop/lid; other site 1116391005133 ABC transporter signature motif; other site 1116391005134 Walker B; other site 1116391005135 D-loop; other site 1116391005136 H-loop/switch region; other site 1116391005137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391005138 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391005139 putative substrate translocation pore; other site 1116391005140 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1116391005141 6-phosphofructokinase; Provisional; Region: PRK03202 1116391005142 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1116391005143 active site 1116391005144 ADP/pyrophosphate binding site [chemical binding]; other site 1116391005145 dimerization interface [polypeptide binding]; other site 1116391005146 allosteric effector site; other site 1116391005147 fructose-1,6-bisphosphate binding site; other site 1116391005148 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 1116391005149 Predicted flavoprotein [General function prediction only]; Region: COG0431 1116391005150 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1116391005151 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1116391005152 ligand binding site [chemical binding]; other site 1116391005153 active site 1116391005154 UGI interface [polypeptide binding]; other site 1116391005155 catalytic site [active] 1116391005156 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1116391005157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391005158 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391005159 putative substrate translocation pore; other site 1116391005160 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1116391005161 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1116391005162 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1116391005163 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1116391005164 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1116391005165 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1116391005166 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1116391005167 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1116391005168 helicase 45; Provisional; Region: PTZ00424 1116391005169 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1116391005170 ATP binding site [chemical binding]; other site 1116391005171 Mg++ binding site [ion binding]; other site 1116391005172 motif III; other site 1116391005173 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1116391005174 nucleotide binding region [chemical binding]; other site 1116391005175 ATP-binding site [chemical binding]; other site 1116391005176 Protein of unknown function, DUF624; Region: DUF624; cl02369 1116391005177 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1116391005178 active site 1116391005179 intersubunit interactions; other site 1116391005180 catalytic residue [active] 1116391005181 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1116391005182 N- and C-terminal domain interface [polypeptide binding]; other site 1116391005183 D-xylulose kinase; Region: XylB; TIGR01312 1116391005184 active site 1116391005185 MgATP binding site [chemical binding]; other site 1116391005186 catalytic site [active] 1116391005187 metal binding site [ion binding]; metal-binding site 1116391005188 xylulose binding site [chemical binding]; other site 1116391005189 homodimer interface [polypeptide binding]; other site 1116391005190 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1116391005191 non-specific DNA interactions [nucleotide binding]; other site 1116391005192 DNA binding site [nucleotide binding] 1116391005193 sequence specific DNA binding site [nucleotide binding]; other site 1116391005194 putative cAMP binding site [chemical binding]; other site 1116391005195 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1116391005196 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1116391005197 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1116391005198 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 1116391005199 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1116391005200 dimer interface [polypeptide binding]; other site 1116391005201 catalytic triad [active] 1116391005202 peroxidatic and resolving cysteines [active] 1116391005203 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391005204 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391005205 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1116391005206 putative dimerization interface [polypeptide binding]; other site 1116391005207 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1116391005208 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1116391005209 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1116391005210 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 1116391005211 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 1116391005212 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1116391005213 DNA binding residues [nucleotide binding] 1116391005214 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1116391005215 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1116391005216 metal binding triad; other site 1116391005217 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 1116391005218 hypothetical protein; Provisional; Region: PRK07740 1116391005219 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1116391005220 active site 1116391005221 catalytic site [active] 1116391005222 substrate binding site [chemical binding]; other site 1116391005223 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070 1116391005224 MPN+ (JAMM) motif; other site 1116391005225 Zinc-binding site [ion binding]; other site 1116391005226 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391005227 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391005228 putative substrate translocation pore; other site 1116391005229 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1116391005230 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1116391005231 catalytic residues [active] 1116391005232 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1116391005233 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1116391005234 active site 1116391005235 catalytic residues [active] 1116391005236 metal binding site [ion binding]; metal-binding site 1116391005237 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1116391005238 DNA polymerase IV; Validated; Region: PRK01810 1116391005239 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1116391005240 active site 1116391005241 DNA binding site [nucleotide binding] 1116391005242 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1116391005243 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1116391005244 Walker A motif; other site 1116391005245 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1116391005246 CHASE2 domain; Region: CHASE2; pfam05226 1116391005247 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1116391005248 cyclase homology domain; Region: CHD; cd07302 1116391005249 nucleotidyl binding site; other site 1116391005250 metal binding site [ion binding]; metal-binding site 1116391005251 dimer interface [polypeptide binding]; other site 1116391005252 FecR protein; Region: FecR; pfam04773 1116391005253 NHL repeat; Region: NHL; pfam01436 1116391005254 NHL repeat; Region: NHL; pfam01436 1116391005255 NHL repeat; Region: NHL; pfam01436 1116391005256 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391005257 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1116391005258 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1116391005259 quinone interaction residues [chemical binding]; other site 1116391005260 active site 1116391005261 catalytic residues [active] 1116391005262 FMN binding site [chemical binding]; other site 1116391005263 substrate binding site [chemical binding]; other site 1116391005264 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1116391005265 synthetase active site [active] 1116391005266 NTP binding site [chemical binding]; other site 1116391005267 metal binding site [ion binding]; metal-binding site 1116391005268 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1116391005269 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1116391005270 catalytic residues [active] 1116391005271 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1116391005272 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391005273 S-adenosylmethionine binding site [chemical binding]; other site 1116391005274 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1116391005275 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1116391005276 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1116391005277 RNA binding surface [nucleotide binding]; other site 1116391005278 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1116391005279 active site 1116391005280 uracil binding [chemical binding]; other site 1116391005281 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1116391005282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391005283 active site 1116391005284 motif I; other site 1116391005285 motif II; other site 1116391005286 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1116391005287 CsbD-like; Region: CsbD; cl17424 1116391005288 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1116391005289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391005290 S-adenosylmethionine binding site [chemical binding]; other site 1116391005291 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1116391005292 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1116391005293 active site 1116391005294 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 1116391005295 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391005296 FeS/SAM binding site; other site 1116391005297 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1116391005298 Ligand Binding Site [chemical binding]; other site 1116391005299 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1116391005300 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391005301 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391005302 metal binding site [ion binding]; metal-binding site 1116391005303 active site 1116391005304 I-site; other site 1116391005305 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391005306 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1116391005307 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1116391005308 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391005309 NAD(P) binding site [chemical binding]; other site 1116391005310 active site 1116391005311 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1116391005312 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1116391005313 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1116391005314 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1116391005315 active site 1116391005316 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 1116391005317 Transposase domain (DUF772); Region: DUF772; pfam05598 1116391005318 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1116391005319 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1116391005320 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1116391005321 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 1116391005322 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1116391005323 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391005324 Coenzyme A binding pocket [chemical binding]; other site 1116391005325 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1116391005326 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1116391005327 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1116391005328 active site 1116391005329 HIGH motif; other site 1116391005330 KMSK motif region; other site 1116391005331 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1116391005332 tRNA binding surface [nucleotide binding]; other site 1116391005333 anticodon binding site; other site 1116391005334 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1116391005335 YqzE-like protein; Region: YqzE; pfam14038 1116391005336 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1116391005337 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1116391005338 transmembrane helices; other site 1116391005339 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1116391005340 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1116391005341 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1116391005342 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1116391005343 ATP binding site [chemical binding]; other site 1116391005344 putative Mg++ binding site [ion binding]; other site 1116391005345 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1116391005346 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1116391005347 nucleotide binding region [chemical binding]; other site 1116391005348 ATP-binding site [chemical binding]; other site 1116391005349 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1116391005350 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1116391005351 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1116391005352 homodimer interface [polypeptide binding]; other site 1116391005353 substrate-cofactor binding pocket; other site 1116391005354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391005355 catalytic residue [active] 1116391005356 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1116391005357 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 1116391005358 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1116391005359 active site 1116391005360 dimer interface [polypeptide binding]; other site 1116391005361 effector binding site; other site 1116391005362 TSCPD domain; Region: TSCPD; pfam12637 1116391005363 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 1116391005364 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1116391005365 dimerization interface [polypeptide binding]; other site 1116391005366 mannose binding site [chemical binding]; other site 1116391005367 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 1116391005368 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 1116391005369 putative metal binding site [ion binding]; other site 1116391005370 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391005371 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391005372 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391005373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005374 dimer interface [polypeptide binding]; other site 1116391005375 conserved gate region; other site 1116391005376 putative PBP binding loops; other site 1116391005377 ABC-ATPase subunit interface; other site 1116391005378 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1116391005379 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1116391005380 inhibitor binding site; inhibition site 1116391005381 active site 1116391005382 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1116391005383 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1116391005384 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 1116391005385 catalytic site [active] 1116391005386 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1116391005387 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391005388 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391005389 dimerization interface [polypeptide binding]; other site 1116391005390 Histidine kinase; Region: His_kinase; pfam06580 1116391005391 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391005392 ATP binding site [chemical binding]; other site 1116391005393 Mg2+ binding site [ion binding]; other site 1116391005394 G-X-G motif; other site 1116391005395 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391005396 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391005397 active site 1116391005398 phosphorylation site [posttranslational modification] 1116391005399 intermolecular recognition site; other site 1116391005400 dimerization interface [polypeptide binding]; other site 1116391005401 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005402 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391005403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005404 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1116391005405 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391005406 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391005407 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005408 dimer interface [polypeptide binding]; other site 1116391005409 conserved gate region; other site 1116391005410 putative PBP binding loops; other site 1116391005411 ABC-ATPase subunit interface; other site 1116391005412 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391005413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005414 dimer interface [polypeptide binding]; other site 1116391005415 conserved gate region; other site 1116391005416 putative PBP binding loops; other site 1116391005417 ABC-ATPase subunit interface; other site 1116391005418 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391005419 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1116391005420 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 1116391005421 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391005422 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005423 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1116391005424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1116391005425 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1116391005426 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1116391005427 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391005428 dimerization interface [polypeptide binding]; other site 1116391005429 Histidine kinase; Region: His_kinase; pfam06580 1116391005430 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391005431 ATP binding site [chemical binding]; other site 1116391005432 Mg2+ binding site [ion binding]; other site 1116391005433 G-X-G motif; other site 1116391005434 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1116391005435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391005436 active site 1116391005437 phosphorylation site [posttranslational modification] 1116391005438 intermolecular recognition site; other site 1116391005439 dimerization interface [polypeptide binding]; other site 1116391005440 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005441 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005442 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391005443 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391005444 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1116391005445 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1116391005446 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391005447 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1116391005448 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391005449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005450 dimer interface [polypeptide binding]; other site 1116391005451 conserved gate region; other site 1116391005452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391005453 ABC-ATPase subunit interface; other site 1116391005454 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391005455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005456 ABC-ATPase subunit interface; other site 1116391005457 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1116391005458 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005459 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391005460 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005461 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391005462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005463 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391005464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005465 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1116391005466 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391005467 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391005468 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005469 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391005470 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391005471 active site 1116391005472 catalytic tetrad [active] 1116391005473 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1116391005474 beta-D-glucuronidase; Provisional; Region: PRK10150 1116391005475 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1116391005476 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391005477 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1116391005478 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1116391005479 classical (c) SDRs; Region: SDR_c; cd05233 1116391005480 NAD(P) binding site [chemical binding]; other site 1116391005481 active site 1116391005482 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1116391005483 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391005484 NAD(P) binding site [chemical binding]; other site 1116391005485 active site 1116391005486 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391005487 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391005488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005489 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005490 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1116391005491 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1116391005492 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1116391005493 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391005494 Interdomain contacts; other site 1116391005495 Cytokine receptor motif; other site 1116391005496 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391005497 Interdomain contacts; other site 1116391005498 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391005499 Interdomain contacts; other site 1116391005500 Cytokine receptor motif; other site 1116391005501 Melibiase; Region: Melibiase; pfam02065 1116391005502 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1116391005503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391005504 active site 1116391005505 phosphorylation site [posttranslational modification] 1116391005506 intermolecular recognition site; other site 1116391005507 dimerization interface [polypeptide binding]; other site 1116391005508 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005509 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391005511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391005512 dimerization interface [polypeptide binding]; other site 1116391005513 Histidine kinase; Region: His_kinase; pfam06580 1116391005514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391005515 ATP binding site [chemical binding]; other site 1116391005516 Mg2+ binding site [ion binding]; other site 1116391005517 G-X-G motif; other site 1116391005518 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391005519 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005520 dimer interface [polypeptide binding]; other site 1116391005521 conserved gate region; other site 1116391005522 ABC-ATPase subunit interface; other site 1116391005523 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391005524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005525 ABC-ATPase subunit interface; other site 1116391005526 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391005527 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1116391005528 Right handed beta helix region; Region: Beta_helix; pfam13229 1116391005529 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1116391005530 metal binding site [ion binding]; metal-binding site 1116391005531 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 1116391005532 Ca binding site [ion binding]; other site 1116391005533 Ca binding site (active) [ion binding]; other site 1116391005534 ligand binding site [chemical binding]; other site 1116391005535 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1116391005536 putative ligand binding site [chemical binding]; other site 1116391005537 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1116391005538 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1116391005539 Right handed beta helix region; Region: Beta_helix; pfam13229 1116391005540 Spore germination protein; Region: Spore_permease; cl17796 1116391005541 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391005542 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391005543 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 1116391005544 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1116391005545 Cupin domain; Region: Cupin_2; pfam07883 1116391005546 Protein of unknown function (DUF1699); Region: DUF1699; pfam08004 1116391005547 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391005548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005549 FAD binding domain; Region: FAD_binding_1; pfam00667 1116391005550 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1116391005551 FAD binding pocket [chemical binding]; other site 1116391005552 FAD binding motif [chemical binding]; other site 1116391005553 catalytic residues [active] 1116391005554 NAD binding pocket [chemical binding]; other site 1116391005555 phosphate binding motif [ion binding]; other site 1116391005556 beta-alpha-beta structure motif; other site 1116391005557 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391005558 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391005559 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005560 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391005561 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391005562 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1116391005563 dimer interface [polypeptide binding]; other site 1116391005564 active site 1116391005565 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1116391005566 dimer interface [polypeptide binding]; other site 1116391005567 active site 1116391005568 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 1116391005569 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1116391005570 substrate binding site [chemical binding]; other site 1116391005571 ATP binding site [chemical binding]; other site 1116391005572 alpha-mannosidase; Provisional; Region: PRK09819 1116391005573 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1116391005574 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1116391005575 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1116391005576 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391005577 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391005578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005579 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1116391005580 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1116391005581 substrate binding site [chemical binding]; other site 1116391005582 dimer interface [polypeptide binding]; other site 1116391005583 ATP binding site [chemical binding]; other site 1116391005584 PAS fold; Region: PAS_4; pfam08448 1116391005585 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391005586 putative active site [active] 1116391005587 heme pocket [chemical binding]; other site 1116391005588 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391005589 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391005590 metal binding site [ion binding]; metal-binding site 1116391005591 active site 1116391005592 I-site; other site 1116391005593 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1116391005594 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391005595 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391005596 metal binding site [ion binding]; metal-binding site 1116391005597 active site 1116391005598 I-site; other site 1116391005599 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1116391005600 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391005601 non-specific DNA binding site [nucleotide binding]; other site 1116391005602 salt bridge; other site 1116391005603 sequence-specific DNA binding site [nucleotide binding]; other site 1116391005604 Cupin domain; Region: Cupin_2; pfam07883 1116391005605 Cupin domain; Region: Cupin_2; pfam07883 1116391005606 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1116391005607 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391005608 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391005609 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1116391005610 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1116391005611 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391005612 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005613 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391005614 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005615 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1116391005616 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391005617 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391005618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005619 dimer interface [polypeptide binding]; other site 1116391005620 conserved gate region; other site 1116391005621 putative PBP binding loops; other site 1116391005622 ABC-ATPase subunit interface; other site 1116391005623 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391005624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005625 dimer interface [polypeptide binding]; other site 1116391005626 conserved gate region; other site 1116391005627 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1116391005628 ABC-ATPase subunit interface; other site 1116391005629 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391005630 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005631 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391005632 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391005633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005635 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 1116391005636 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 1116391005637 iron-sulfur cluster [ion binding]; other site 1116391005638 [2Fe-2S] cluster binding site [ion binding]; other site 1116391005639 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1116391005640 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 1116391005641 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391005642 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391005643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005644 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391005645 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005646 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391005647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005648 dimer interface [polypeptide binding]; other site 1116391005649 conserved gate region; other site 1116391005650 ABC-ATPase subunit interface; other site 1116391005651 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391005652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005653 dimer interface [polypeptide binding]; other site 1116391005654 conserved gate region; other site 1116391005655 ABC-ATPase subunit interface; other site 1116391005656 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391005657 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391005658 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 1116391005659 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391005660 Spore germination protein; Region: Spore_permease; cl17796 1116391005661 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391005662 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391005663 Predicted transcriptional regulators [Transcription]; Region: COG1695 1116391005664 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1116391005665 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 1116391005666 Protein of unknown function (DUF1048); Region: DUF1048; pfam06304 1116391005667 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1116391005668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391005669 Walker A/P-loop; other site 1116391005670 ATP binding site [chemical binding]; other site 1116391005671 Q-loop/lid; other site 1116391005672 ABC transporter signature motif; other site 1116391005673 Walker B; other site 1116391005674 D-loop; other site 1116391005675 H-loop/switch region; other site 1116391005676 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1116391005677 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1116391005678 HAMP domain; Region: HAMP; pfam00672 1116391005679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391005680 dimer interface [polypeptide binding]; other site 1116391005681 phosphorylation site [posttranslational modification] 1116391005682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391005683 ATP binding site [chemical binding]; other site 1116391005684 Mg2+ binding site [ion binding]; other site 1116391005685 G-X-G motif; other site 1116391005686 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391005687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391005688 active site 1116391005689 phosphorylation site [posttranslational modification] 1116391005690 intermolecular recognition site; other site 1116391005691 dimerization interface [polypeptide binding]; other site 1116391005692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391005693 DNA binding site [nucleotide binding] 1116391005694 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1116391005695 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1116391005696 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1116391005697 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1116391005698 HEAT repeats; Region: HEAT_2; pfam13646 1116391005699 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391005700 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391005701 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005702 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 1116391005703 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1116391005704 putative ligand binding site [chemical binding]; other site 1116391005705 putative NAD binding site [chemical binding]; other site 1116391005706 catalytic site [active] 1116391005707 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1116391005708 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1116391005709 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1116391005710 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1116391005711 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1116391005712 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1116391005713 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005714 Helix-turn-helix domain; Region: HTH_18; pfam12833 1116391005715 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1116391005716 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391005717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005718 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391005719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005720 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391005721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391005722 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391005723 dimerization interface [polypeptide binding]; other site 1116391005724 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391005725 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391005726 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391005727 dimerization interface [polypeptide binding]; other site 1116391005728 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1116391005729 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391005730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391005731 dimerization interface [polypeptide binding]; other site 1116391005732 Histidine kinase; Region: His_kinase; pfam06580 1116391005733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391005734 ATP binding site [chemical binding]; other site 1116391005735 Mg2+ binding site [ion binding]; other site 1116391005736 G-X-G motif; other site 1116391005737 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391005738 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391005739 active site 1116391005740 phosphorylation site [posttranslational modification] 1116391005741 intermolecular recognition site; other site 1116391005742 dimerization interface [polypeptide binding]; other site 1116391005743 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391005744 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391005746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391005747 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1116391005748 dimerization interface [polypeptide binding]; other site 1116391005749 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1116391005750 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1116391005751 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391005752 active site 1116391005753 metal binding site [ion binding]; metal-binding site 1116391005754 PKD domain; Region: PKD; pfam00801 1116391005755 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391005756 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391005757 dimerization interface [polypeptide binding]; other site 1116391005758 Histidine kinase; Region: His_kinase; pfam06580 1116391005759 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1116391005760 Mg2+ binding site [ion binding]; other site 1116391005761 G-X-G motif; other site 1116391005762 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391005763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391005764 active site 1116391005765 phosphorylation site [posttranslational modification] 1116391005766 intermolecular recognition site; other site 1116391005767 dimerization interface [polypeptide binding]; other site 1116391005768 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391005769 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005770 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391005771 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391005772 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391005773 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391005774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005775 dimer interface [polypeptide binding]; other site 1116391005776 ABC-ATPase subunit interface; other site 1116391005777 putative PBP binding loops; other site 1116391005778 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391005779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005780 dimer interface [polypeptide binding]; other site 1116391005781 conserved gate region; other site 1116391005782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391005783 ABC-ATPase subunit interface; other site 1116391005784 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 1116391005785 active site 1116391005786 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1116391005787 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1116391005788 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1116391005789 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1116391005790 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 1116391005791 active site 1116391005792 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1116391005793 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1116391005794 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 1116391005795 active site 1116391005796 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391005797 Interdomain contacts; other site 1116391005798 Cytokine receptor motif; other site 1116391005799 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1116391005800 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1116391005801 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391005802 Interdomain contacts; other site 1116391005803 Cytokine receptor motif; other site 1116391005804 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 1116391005805 dockerin binding interface; other site 1116391005806 Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788 1116391005807 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1116391005808 DNA binding residues [nucleotide binding] 1116391005809 putative dimer interface [polypeptide binding]; other site 1116391005810 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 1116391005811 putative hydrophobic ligand binding site [chemical binding]; other site 1116391005812 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 1116391005813 putative hydrophobic ligand binding site [chemical binding]; other site 1116391005814 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1116391005815 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391005816 NAD(P) binding site [chemical binding]; other site 1116391005817 active site 1116391005818 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1116391005819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391005820 Helix-turn-helix domain; Region: HTH_18; pfam12833 1116391005821 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1116391005822 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391005823 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1116391005824 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391005825 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391005826 Transposase; Region: HTH_Tnp_1; cl17663 1116391005827 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391005828 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391005829 HTH-like domain; Region: HTH_21; pfam13276 1116391005830 Integrase core domain; Region: rve; pfam00665 1116391005831 Integrase core domain; Region: rve_2; pfam13333 1116391005832 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391005833 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391005834 LytTr DNA-binding domain; Region: LytTR; smart00850 1116391005835 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1116391005836 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1116391005837 Transcription antiterminator [Transcription]; Region: NusG; COG0250 1116391005838 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 1116391005839 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 1116391005840 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1116391005841 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1116391005842 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1116391005843 FMN binding site [chemical binding]; other site 1116391005844 substrate binding site [chemical binding]; other site 1116391005845 putative catalytic residue [active] 1116391005846 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1116391005847 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1116391005848 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1116391005849 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1116391005850 active site 1116391005851 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1116391005852 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1116391005853 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1116391005854 putative NADP binding site [chemical binding]; other site 1116391005855 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1116391005856 active site 1116391005857 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391005858 S-adenosylmethionine binding site [chemical binding]; other site 1116391005859 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1116391005860 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1116391005861 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1116391005862 active site 1116391005863 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1116391005864 KR domain; Region: KR; pfam08659 1116391005865 putative NADP binding site [chemical binding]; other site 1116391005866 active site 1116391005867 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391005868 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1116391005869 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1116391005870 active site 1116391005871 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391005872 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1116391005873 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1116391005874 active site 1116391005875 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1116391005876 putative NADP binding site [chemical binding]; other site 1116391005877 KR domain; Region: KR; pfam08659 1116391005878 active site 1116391005879 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391005880 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1116391005881 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1116391005882 active site 1116391005883 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391005884 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1116391005885 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1116391005886 active site 1116391005887 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1116391005888 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1116391005889 putative NADP binding site [chemical binding]; other site 1116391005890 KR domain; Region: KR; pfam08659 1116391005891 active site 1116391005892 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1116391005893 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1116391005894 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1116391005895 active site 1116391005896 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391005897 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1116391005898 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1116391005899 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1116391005900 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1116391005901 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1116391005902 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1116391005903 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1116391005904 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1116391005905 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391005906 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391005907 DNA binding site [nucleotide binding] 1116391005908 domain linker motif; other site 1116391005909 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1116391005910 dimerization interface [polypeptide binding]; other site 1116391005911 ligand binding site [chemical binding]; other site 1116391005912 sodium binding site [ion binding]; other site 1116391005913 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391005914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005915 dimer interface [polypeptide binding]; other site 1116391005916 conserved gate region; other site 1116391005917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391005918 ABC-ATPase subunit interface; other site 1116391005919 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391005920 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1116391005921 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1116391005922 substrate binding [chemical binding]; other site 1116391005923 active site 1116391005924 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1116391005925 Phosphotransferase enzyme family; Region: APH; pfam01636 1116391005926 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1116391005927 active site 1116391005928 ATP binding site [chemical binding]; other site 1116391005929 substrate binding site [chemical binding]; other site 1116391005930 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1116391005931 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1116391005932 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1116391005933 substrate binding [chemical binding]; other site 1116391005934 active site 1116391005935 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1116391005936 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1116391005937 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1116391005938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391005939 putative substrate translocation pore; other site 1116391005940 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1116391005941 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1116391005942 inhibitor-cofactor binding pocket; inhibition site 1116391005943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391005944 catalytic residue [active] 1116391005945 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1116391005946 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1116391005947 NAD(P) binding site [chemical binding]; other site 1116391005948 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1116391005949 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391005950 motif II; other site 1116391005951 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1116391005952 active site 1116391005953 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 1116391005954 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1116391005955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 1116391005956 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 1116391005957 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1116391005958 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1116391005959 substrate binding site [chemical binding]; other site 1116391005960 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1116391005961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005962 dimer interface [polypeptide binding]; other site 1116391005963 conserved gate region; other site 1116391005964 putative PBP binding loops; other site 1116391005965 ABC-ATPase subunit interface; other site 1116391005966 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1116391005967 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1116391005968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391005969 dimer interface [polypeptide binding]; other site 1116391005970 conserved gate region; other site 1116391005971 putative PBP binding loops; other site 1116391005972 ABC-ATPase subunit interface; other site 1116391005973 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391005974 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1116391005975 Walker A/P-loop; other site 1116391005976 ATP binding site [chemical binding]; other site 1116391005977 Q-loop/lid; other site 1116391005978 ABC transporter signature motif; other site 1116391005979 Walker B; other site 1116391005980 D-loop; other site 1116391005981 H-loop/switch region; other site 1116391005982 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1116391005983 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391005984 Walker A/P-loop; other site 1116391005985 ATP binding site [chemical binding]; other site 1116391005986 Q-loop/lid; other site 1116391005987 ABC transporter signature motif; other site 1116391005988 Walker B; other site 1116391005989 D-loop; other site 1116391005990 H-loop/switch region; other site 1116391005991 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391005992 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391005993 putative substrate translocation pore; other site 1116391005994 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391005995 dimerization interface [polypeptide binding]; other site 1116391005996 putative DNA binding site [nucleotide binding]; other site 1116391005997 putative Zn2+ binding site [ion binding]; other site 1116391005998 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1116391005999 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1116391006000 metal-binding site [ion binding] 1116391006001 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1116391006002 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1116391006003 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1116391006004 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1116391006005 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1116391006006 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391006007 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1116391006008 dimerization interface [polypeptide binding]; other site 1116391006009 substrate binding pocket [chemical binding]; other site 1116391006010 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1116391006011 putative deacylase active site [active] 1116391006012 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391006013 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391006014 Transposase; Region: HTH_Tnp_1; cl17663 1116391006015 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391006016 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391006017 HTH-like domain; Region: HTH_21; pfam13276 1116391006018 Integrase core domain; Region: rve; pfam00665 1116391006019 Integrase core domain; Region: rve_2; pfam13333 1116391006020 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1116391006021 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1116391006022 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1116391006023 Pectate lyase; Region: Pec_lyase_C; cl01593 1116391006024 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 1116391006025 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391006026 Interdomain contacts; other site 1116391006027 Cytokine receptor motif; other site 1116391006028 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391006029 Interdomain contacts; other site 1116391006030 Cytokine receptor motif; other site 1116391006031 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391006032 Interdomain contacts; other site 1116391006033 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391006034 Interdomain contacts; other site 1116391006035 Cytokine receptor motif; other site 1116391006036 putative pectinesterase; Region: PLN02432; cl01911 1116391006037 Pectinesterase; Region: Pectinesterase; pfam01095 1116391006038 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391006039 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006040 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391006041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006042 dimer interface [polypeptide binding]; other site 1116391006043 conserved gate region; other site 1116391006044 ABC-ATPase subunit interface; other site 1116391006045 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006047 dimer interface [polypeptide binding]; other site 1116391006048 conserved gate region; other site 1116391006049 putative PBP binding loops; other site 1116391006050 ABC-ATPase subunit interface; other site 1116391006051 Predicted transcriptional regulators [Transcription]; Region: COG1378 1116391006052 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1116391006053 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1116391006054 C-terminal domain interface [polypeptide binding]; other site 1116391006055 sugar binding site [chemical binding]; other site 1116391006056 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1116391006057 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 1116391006058 YxiJ-like protein; Region: YxiJ; pfam14176 1116391006059 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1116391006060 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391006061 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391006062 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1116391006063 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1116391006064 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1116391006065 NADP binding site [chemical binding]; other site 1116391006066 substrate binding site [chemical binding]; other site 1116391006067 active site 1116391006068 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1116391006069 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1116391006070 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 1116391006071 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1116391006072 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1116391006073 Helix-turn-helix domain; Region: HTH_18; pfam12833 1116391006074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006075 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1116391006076 classical (c) SDRs; Region: SDR_c; cd05233 1116391006077 NAD(P) binding site [chemical binding]; other site 1116391006078 active site 1116391006079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391006080 Walker A/P-loop; other site 1116391006081 ATP binding site [chemical binding]; other site 1116391006082 Q-loop/lid; other site 1116391006083 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1116391006084 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1116391006085 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391006086 Walker A/P-loop; other site 1116391006087 ATP binding site [chemical binding]; other site 1116391006088 Q-loop/lid; other site 1116391006089 ABC transporter signature motif; other site 1116391006090 Walker B; other site 1116391006091 D-loop; other site 1116391006092 H-loop/switch region; other site 1116391006093 DinB family; Region: DinB; cl17821 1116391006094 DinB superfamily; Region: DinB_2; pfam12867 1116391006095 Putative esterase; Region: Esterase; pfam00756 1116391006096 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1116391006097 Cupin domain; Region: Cupin_2; cl17218 1116391006098 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391006099 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006100 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1116391006101 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1116391006102 intersubunit interface [polypeptide binding]; other site 1116391006103 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1116391006104 putative FMN binding site [chemical binding]; other site 1116391006105 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1116391006106 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391006107 ABC-ATPase subunit interface; other site 1116391006108 dimer interface [polypeptide binding]; other site 1116391006109 putative PBP binding regions; other site 1116391006110 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1116391006111 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391006112 ABC-ATPase subunit interface; other site 1116391006113 dimer interface [polypeptide binding]; other site 1116391006114 putative PBP binding regions; other site 1116391006115 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1116391006116 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1116391006117 siderophore binding site; other site 1116391006118 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391006119 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1116391006120 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391006121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391006122 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391006123 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391006124 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391006125 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391006126 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1116391006127 Metal-binding active site; metal-binding site 1116391006128 transketolase; Reviewed; Region: PRK05899 1116391006129 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1116391006130 TPP-binding site [chemical binding]; other site 1116391006131 dimer interface [polypeptide binding]; other site 1116391006132 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1116391006133 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1116391006134 PYR/PP interface [polypeptide binding]; other site 1116391006135 dimer interface [polypeptide binding]; other site 1116391006136 TPP binding site [chemical binding]; other site 1116391006137 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1116391006138 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1116391006139 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1116391006140 NAD(P) binding site [chemical binding]; other site 1116391006141 catalytic residues [active] 1116391006142 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1116391006143 tartrate dehydrogenase; Provisional; Region: PRK08194 1116391006144 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1116391006145 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1116391006146 tetrameric interface [polypeptide binding]; other site 1116391006147 NAD binding site [chemical binding]; other site 1116391006148 catalytic residues [active] 1116391006149 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1116391006150 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1116391006151 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1116391006152 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1116391006153 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 1116391006154 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1116391006155 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1116391006156 substrate binding site [chemical binding]; other site 1116391006157 ATP binding site [chemical binding]; other site 1116391006158 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1116391006159 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1116391006160 PYR/PP interface [polypeptide binding]; other site 1116391006161 dimer interface [polypeptide binding]; other site 1116391006162 TPP binding site [chemical binding]; other site 1116391006163 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1116391006164 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1116391006165 TPP-binding site; other site 1116391006166 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391006167 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1116391006168 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1116391006169 intersubunit interface [polypeptide binding]; other site 1116391006170 active site 1116391006171 zinc binding site [ion binding]; other site 1116391006172 Na+ binding site [ion binding]; other site 1116391006173 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1116391006174 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1116391006175 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1116391006176 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1116391006177 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1116391006178 active site 1116391006179 dimerization interface [polypeptide binding]; other site 1116391006180 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1116391006181 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1116391006182 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391006183 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391006184 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1116391006185 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1116391006186 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1116391006187 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1116391006188 S-layer homology domain; Region: SLH; pfam00395 1116391006189 S-layer homology domain; Region: SLH; pfam00395 1116391006190 S-layer homology domain; Region: SLH; pfam00395 1116391006191 Cobalt transport protein; Region: CbiQ; cl00463 1116391006192 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1116391006193 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1116391006194 Walker A/P-loop; other site 1116391006195 ATP binding site [chemical binding]; other site 1116391006196 Q-loop/lid; other site 1116391006197 ABC transporter signature motif; other site 1116391006198 Walker B; other site 1116391006199 D-loop; other site 1116391006200 H-loop/switch region; other site 1116391006201 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1116391006202 Walker A/P-loop; other site 1116391006203 ATP binding site [chemical binding]; other site 1116391006204 Q-loop/lid; other site 1116391006205 ABC transporter signature motif; other site 1116391006206 Walker B; other site 1116391006207 D-loop; other site 1116391006208 H-loop/switch region; other site 1116391006209 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1116391006210 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1116391006211 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391006212 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391006213 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391006214 dimerization interface [polypeptide binding]; other site 1116391006215 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1116391006216 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 1116391006217 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 1116391006218 DinB superfamily; Region: DinB_2; pfam12867 1116391006219 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1116391006220 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391006221 Coenzyme A binding pocket [chemical binding]; other site 1116391006222 Predicted transcriptional regulators [Transcription]; Region: COG1695 1116391006223 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1116391006224 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1116391006225 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391006226 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391006227 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391006228 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391006229 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391006230 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391006231 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391006232 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391006233 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 1116391006234 NmrA-like family; Region: NmrA; pfam05368 1116391006235 NADP binding site [chemical binding]; other site 1116391006236 active site 1116391006237 regulatory binding site [polypeptide binding]; other site 1116391006238 hypothetical protein; Validated; Region: PRK06186 1116391006239 conserved cys residue [active] 1116391006240 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1116391006241 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006242 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006243 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1116391006244 Histidine kinase; Region: His_kinase; pfam06580 1116391006245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391006246 ATP binding site [chemical binding]; other site 1116391006247 Mg2+ binding site [ion binding]; other site 1116391006248 G-X-G motif; other site 1116391006249 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391006250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391006251 active site 1116391006252 phosphorylation site [posttranslational modification] 1116391006253 intermolecular recognition site; other site 1116391006254 dimerization interface [polypeptide binding]; other site 1116391006255 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391006256 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006258 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1116391006259 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1116391006260 substrate binding [chemical binding]; other site 1116391006261 active site 1116391006262 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1116391006263 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391006264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006265 putative PBP binding loops; other site 1116391006266 ABC-ATPase subunit interface; other site 1116391006267 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006269 dimer interface [polypeptide binding]; other site 1116391006270 conserved gate region; other site 1116391006271 putative PBP binding loops; other site 1116391006272 ABC-ATPase subunit interface; other site 1116391006273 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1116391006274 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1116391006275 substrate binding [chemical binding]; other site 1116391006276 active site 1116391006277 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1116391006278 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1116391006279 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1116391006280 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1116391006281 substrate binding [chemical binding]; other site 1116391006282 active site 1116391006283 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1116391006284 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391006285 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391006286 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1116391006287 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1116391006288 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391006289 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391006290 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 1116391006291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391006292 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391006293 putative substrate translocation pore; other site 1116391006294 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1116391006295 BclB C-terminal domain; Region: exospore_TM; TIGR03721 1116391006296 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391006297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006298 dimer interface [polypeptide binding]; other site 1116391006299 conserved gate region; other site 1116391006300 ABC-ATPase subunit interface; other site 1116391006301 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006303 dimer interface [polypeptide binding]; other site 1116391006304 conserved gate region; other site 1116391006305 putative PBP binding loops; other site 1116391006306 ABC-ATPase subunit interface; other site 1116391006307 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006308 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006309 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391006310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006311 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391006312 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391006313 Predicted membrane protein [Function unknown]; Region: COG4270 1116391006314 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1116391006315 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1116391006316 putative NAD(P) binding site [chemical binding]; other site 1116391006317 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1116391006318 active site 1116391006319 catalytic triad [active] 1116391006320 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1116391006321 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1116391006322 putative active cleft [active] 1116391006323 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391006324 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006325 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391006326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006327 dimer interface [polypeptide binding]; other site 1116391006328 conserved gate region; other site 1116391006329 ABC-ATPase subunit interface; other site 1116391006330 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006332 dimer interface [polypeptide binding]; other site 1116391006333 conserved gate region; other site 1116391006334 putative PBP binding loops; other site 1116391006335 ABC-ATPase subunit interface; other site 1116391006336 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006337 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1116391006338 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391006339 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391006340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006341 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 1116391006342 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1116391006343 metal binding site [ion binding]; metal-binding site 1116391006344 active site 1116391006345 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391006346 Interdomain contacts; other site 1116391006347 Cytokine receptor motif; other site 1116391006348 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1116391006349 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 1116391006350 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1116391006351 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 1116391006352 putative ligand binding site [chemical binding]; other site 1116391006353 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1116391006354 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1116391006355 Walker A/P-loop; other site 1116391006356 ATP binding site [chemical binding]; other site 1116391006357 Q-loop/lid; other site 1116391006358 ABC transporter signature motif; other site 1116391006359 Walker B; other site 1116391006360 D-loop; other site 1116391006361 H-loop/switch region; other site 1116391006362 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1116391006363 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391006364 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1116391006365 TM-ABC transporter signature motif; other site 1116391006366 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391006367 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391006368 DNA binding site [nucleotide binding] 1116391006369 domain linker motif; other site 1116391006370 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1116391006371 dimerization interface [polypeptide binding]; other site 1116391006372 ligand binding site [chemical binding]; other site 1116391006373 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391006374 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391006375 DNA binding site [nucleotide binding] 1116391006376 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1116391006377 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391006378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006379 ABC-ATPase subunit interface; other site 1116391006380 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006382 dimer interface [polypeptide binding]; other site 1116391006383 conserved gate region; other site 1116391006384 putative PBP binding loops; other site 1116391006385 ABC-ATPase subunit interface; other site 1116391006386 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006387 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006388 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1116391006389 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1116391006390 substrate binding [chemical binding]; other site 1116391006391 active site 1116391006392 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1116391006393 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1116391006394 Isochorismatase family; Region: Isochorismatase; pfam00857 1116391006395 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1116391006396 catalytic triad [active] 1116391006397 dimer interface [polypeptide binding]; other site 1116391006398 conserved cis-peptide bond; other site 1116391006399 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 1116391006400 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1116391006401 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1116391006402 active site 1116391006403 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1116391006404 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1116391006405 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1116391006406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391006407 putative substrate translocation pore; other site 1116391006408 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1116391006409 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1116391006410 dimerization interface [polypeptide binding]; other site 1116391006411 DPS ferroxidase diiron center [ion binding]; other site 1116391006412 ion pore; other site 1116391006413 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1116391006414 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1116391006415 substrate binding pocket [chemical binding]; other site 1116391006416 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1116391006417 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1116391006418 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391006419 Zn binding site [ion binding]; other site 1116391006420 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1116391006421 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391006422 Zn binding site [ion binding]; other site 1116391006423 Predicted esterase [General function prediction only]; Region: COG0400 1116391006424 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1116391006425 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1116391006426 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1116391006427 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1116391006428 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391006429 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391006430 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006431 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006432 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1116391006433 Protein of unknown function (DUF3024); Region: DUF3024; pfam11225 1116391006434 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1116391006435 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1116391006436 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1116391006437 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 1116391006438 putative DNA binding site [nucleotide binding]; other site 1116391006439 putative Zn2+ binding site [ion binding]; other site 1116391006440 AsnC family; Region: AsnC_trans_reg; pfam01037 1116391006441 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391006442 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391006443 dimerization interface [polypeptide binding]; other site 1116391006444 putative DNA binding site [nucleotide binding]; other site 1116391006445 putative Zn2+ binding site [ion binding]; other site 1116391006446 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1116391006447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391006448 putative substrate translocation pore; other site 1116391006449 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391006450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006451 dimer interface [polypeptide binding]; other site 1116391006452 conserved gate region; other site 1116391006453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391006454 ABC-ATPase subunit interface; other site 1116391006455 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006457 dimer interface [polypeptide binding]; other site 1116391006458 conserved gate region; other site 1116391006459 putative PBP binding loops; other site 1116391006460 ABC-ATPase subunit interface; other site 1116391006461 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006462 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006463 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391006464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006465 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1116391006466 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391006467 ABC-ATPase subunit interface; other site 1116391006468 dimer interface [polypeptide binding]; other site 1116391006469 putative PBP binding regions; other site 1116391006470 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1116391006471 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391006472 ABC-ATPase subunit interface; other site 1116391006473 dimer interface [polypeptide binding]; other site 1116391006474 putative PBP binding regions; other site 1116391006475 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1116391006476 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1116391006477 intersubunit interface [polypeptide binding]; other site 1116391006478 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1116391006479 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 1116391006480 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1116391006481 metal binding site [ion binding]; metal-binding site 1116391006482 active site 1116391006483 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391006484 Interdomain contacts; other site 1116391006485 Cytokine receptor motif; other site 1116391006486 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391006487 Interdomain contacts; other site 1116391006488 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 1116391006489 dockerin binding interface; other site 1116391006490 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1116391006491 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1116391006492 inhibitor binding site; inhibition site 1116391006493 catalytic Zn binding site [ion binding]; other site 1116391006494 structural Zn binding site [ion binding]; other site 1116391006495 NADP binding site [chemical binding]; other site 1116391006496 tetramer interface [polypeptide binding]; other site 1116391006497 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1116391006498 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1116391006499 AAA ATPase domain; Region: AAA_16; pfam13191 1116391006500 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1116391006501 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1116391006502 TPR motif; other site 1116391006503 binding surface 1116391006504 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1116391006505 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391006506 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391006507 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391006508 Spore germination protein; Region: Spore_permease; cl17796 1116391006509 Spore germination protein; Region: Spore_permease; cl17796 1116391006510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391006511 non-specific DNA binding site [nucleotide binding]; other site 1116391006512 salt bridge; other site 1116391006513 sequence-specific DNA binding site [nucleotide binding]; other site 1116391006514 SET domain; Region: SET; pfam00856 1116391006515 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 1116391006516 putative hydrophobic ligand binding site [chemical binding]; other site 1116391006517 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391006518 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006519 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006520 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006521 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391006522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391006523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006524 dimer interface [polypeptide binding]; other site 1116391006525 ABC-ATPase subunit interface; other site 1116391006526 putative PBP binding loops; other site 1116391006527 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006529 dimer interface [polypeptide binding]; other site 1116391006530 conserved gate region; other site 1116391006531 ABC-ATPase subunit interface; other site 1116391006532 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1116391006533 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391006534 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1116391006535 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1116391006536 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1116391006537 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391006538 DNA-binding site [nucleotide binding]; DNA binding site 1116391006539 FCD domain; Region: FCD; pfam07729 1116391006540 mannonate dehydratase; Provisional; Region: PRK03906 1116391006541 mannonate dehydratase; Region: uxuA; TIGR00695 1116391006542 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1116391006543 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 1116391006544 putative NAD(P) binding site [chemical binding]; other site 1116391006545 active site 1116391006546 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1116391006547 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1116391006548 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391006549 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006550 Helix-turn-helix domain; Region: HTH_18; pfam12833 1116391006551 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006552 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 1116391006553 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 1116391006554 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 1116391006555 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 1116391006556 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391006557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006558 dimer interface [polypeptide binding]; other site 1116391006559 putative PBP binding loops; other site 1116391006560 ABC-ATPase subunit interface; other site 1116391006561 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006562 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006563 dimer interface [polypeptide binding]; other site 1116391006564 conserved gate region; other site 1116391006565 putative PBP binding loops; other site 1116391006566 ABC-ATPase subunit interface; other site 1116391006567 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391006568 Histidine kinase; Region: His_kinase; pfam06580 1116391006569 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1116391006570 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006571 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006572 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391006573 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391006574 active site 1116391006575 phosphorylation site [posttranslational modification] 1116391006576 intermolecular recognition site; other site 1116391006577 dimerization interface [polypeptide binding]; other site 1116391006578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006579 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391006580 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006581 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1116391006582 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 1116391006583 inhibitor binding site; inhibition site 1116391006584 catalytic Zn binding site [ion binding]; other site 1116391006585 structural Zn binding site [ion binding]; other site 1116391006586 NADP binding site [chemical binding]; other site 1116391006587 tetramer interface [polypeptide binding]; other site 1116391006588 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1116391006589 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 1116391006590 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1116391006591 active site 1116391006592 DNA binding site [nucleotide binding] 1116391006593 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 1116391006594 Benzoate membrane transport protein; Region: BenE; pfam03594 1116391006595 benzoate transporter; Region: benE; TIGR00843 1116391006596 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1116391006597 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1116391006598 NAD binding site [chemical binding]; other site 1116391006599 substrate binding site [chemical binding]; other site 1116391006600 putative active site [active] 1116391006601 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1116391006602 UbiA prenyltransferase family; Region: UbiA; pfam01040 1116391006603 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391006604 Helix-turn-helix domain; Region: HTH_18; pfam12833 1116391006605 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006606 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1116391006607 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1116391006608 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 1116391006609 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1116391006610 NAD(P) binding site [chemical binding]; other site 1116391006611 catalytic residues [active] 1116391006612 putative dehydratase; Provisional; Region: PRK08211 1116391006613 Dehydratase family; Region: ILVD_EDD; cl00340 1116391006614 malate:quinone oxidoreductase; Validated; Region: PRK05257 1116391006615 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1116391006616 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391006617 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391006618 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391006619 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1116391006621 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1116391006622 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1116391006623 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1116391006624 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1116391006625 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391006626 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006627 Cupin domain; Region: Cupin_2; pfam07883 1116391006628 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391006629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006630 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1116391006631 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1116391006632 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1116391006633 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1116391006634 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1116391006635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391006636 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1116391006637 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1116391006638 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1116391006639 dimerization domain swap beta strand [polypeptide binding]; other site 1116391006640 regulatory protein interface [polypeptide binding]; other site 1116391006641 active site 1116391006642 regulatory phosphorylation site [posttranslational modification]; other site 1116391006643 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1116391006644 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1116391006645 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1116391006646 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006647 dimer interface [polypeptide binding]; other site 1116391006648 conserved gate region; other site 1116391006649 ABC-ATPase subunit interface; other site 1116391006650 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006652 dimer interface [polypeptide binding]; other site 1116391006653 conserved gate region; other site 1116391006654 ABC-ATPase subunit interface; other site 1116391006655 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1116391006656 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1116391006657 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006658 S-layer homology domain; Region: SLH; pfam00395 1116391006659 S-layer homology domain; Region: SLH; pfam00395 1116391006660 S-layer homology domain; Region: SLH; pfam00395 1116391006661 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1116391006662 Carbohydrate binding module 27; Region: CBM27; pfam09212 1116391006663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391006664 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391006665 dimerization interface [polypeptide binding]; other site 1116391006666 Histidine kinase; Region: His_kinase; pfam06580 1116391006667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391006668 ATP binding site [chemical binding]; other site 1116391006669 Mg2+ binding site [ion binding]; other site 1116391006670 G-X-G motif; other site 1116391006671 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1116391006672 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391006673 active site 1116391006674 phosphorylation site [posttranslational modification] 1116391006675 intermolecular recognition site; other site 1116391006676 dimerization interface [polypeptide binding]; other site 1116391006677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006678 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006679 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006680 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1116391006681 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1116391006682 active site 1116391006683 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1116391006684 dimerization interface [polypeptide binding]; other site 1116391006685 putative active cleft [active] 1116391006686 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 1116391006687 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1116391006688 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1116391006689 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1116391006690 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391006691 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391006692 active site 1116391006693 phosphorylation site [posttranslational modification] 1116391006694 intermolecular recognition site; other site 1116391006695 dimerization interface [polypeptide binding]; other site 1116391006696 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391006697 DNA binding site [nucleotide binding] 1116391006698 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 1116391006699 Carbohydrate binding domain; Region: CBM_25; smart01066 1116391006700 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391006701 Interdomain contacts; other site 1116391006702 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1116391006703 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1116391006704 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1116391006705 active site 1116391006706 catalytic site [active] 1116391006707 CHASE3 domain; Region: CHASE3; cl05000 1116391006708 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391006709 dimerization interface [polypeptide binding]; other site 1116391006710 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391006711 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391006712 metal binding site [ion binding]; metal-binding site 1116391006713 active site 1116391006714 I-site; other site 1116391006715 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006716 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006717 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1116391006718 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391006719 active site 1116391006720 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006721 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1116391006722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391006723 dimerization interface [polypeptide binding]; other site 1116391006724 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391006725 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391006726 dimer interface [polypeptide binding]; other site 1116391006727 putative CheW interface [polypeptide binding]; other site 1116391006728 Histidine kinase; Region: His_kinase; pfam06580 1116391006729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391006730 ATP binding site [chemical binding]; other site 1116391006731 Mg2+ binding site [ion binding]; other site 1116391006732 G-X-G motif; other site 1116391006733 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391006734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391006735 active site 1116391006736 phosphorylation site [posttranslational modification] 1116391006737 intermolecular recognition site; other site 1116391006738 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391006739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006740 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006741 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1116391006742 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1116391006743 Ca binding site [ion binding]; other site 1116391006744 active site 1116391006745 catalytic site [active] 1116391006746 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1116391006747 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006748 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1116391006749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006750 dimer interface [polypeptide binding]; other site 1116391006751 conserved gate region; other site 1116391006752 putative PBP binding loops; other site 1116391006753 ABC-ATPase subunit interface; other site 1116391006754 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006756 dimer interface [polypeptide binding]; other site 1116391006757 conserved gate region; other site 1116391006758 putative PBP binding loops; other site 1116391006759 ABC-ATPase subunit interface; other site 1116391006760 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 1116391006761 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1116391006762 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1116391006763 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1116391006764 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1116391006765 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1116391006766 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1116391006767 putative metal binding site [ion binding]; other site 1116391006768 Arrestin (or S-antigen), C-terminal domain; Region: Arrestin_C; pfam02752 1116391006769 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 1116391006770 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1116391006771 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391006772 Interdomain contacts; other site 1116391006773 Cytokine receptor motif; other site 1116391006774 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 1116391006775 dockerin binding interface; other site 1116391006776 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391006777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391006778 dimerization interface [polypeptide binding]; other site 1116391006779 Histidine kinase; Region: His_kinase; pfam06580 1116391006780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391006781 ATP binding site [chemical binding]; other site 1116391006782 Mg2+ binding site [ion binding]; other site 1116391006783 G-X-G motif; other site 1116391006784 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391006785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391006786 active site 1116391006787 phosphorylation site [posttranslational modification] 1116391006788 intermolecular recognition site; other site 1116391006789 dimerization interface [polypeptide binding]; other site 1116391006790 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006791 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391006792 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006793 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1116391006794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006795 dimer interface [polypeptide binding]; other site 1116391006796 conserved gate region; other site 1116391006797 putative PBP binding loops; other site 1116391006798 ABC-ATPase subunit interface; other site 1116391006799 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006801 dimer interface [polypeptide binding]; other site 1116391006802 conserved gate region; other site 1116391006803 putative PBP binding loops; other site 1116391006804 ABC-ATPase subunit interface; other site 1116391006805 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006806 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006807 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1116391006808 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1116391006809 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391006810 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391006811 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391006812 Spore germination protein; Region: Spore_permease; cl17796 1116391006813 DinB family; Region: DinB; cl17821 1116391006814 DinB superfamily; Region: DinB_2; pfam12867 1116391006815 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391006816 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1116391006817 metal binding site [ion binding]; metal-binding site 1116391006818 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 1116391006819 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391006820 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391006821 dimerization interface [polypeptide binding]; other site 1116391006822 Histidine kinase; Region: His_kinase; pfam06580 1116391006823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391006824 ATP binding site [chemical binding]; other site 1116391006825 Mg2+ binding site [ion binding]; other site 1116391006826 G-X-G motif; other site 1116391006827 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391006828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391006829 active site 1116391006830 phosphorylation site [posttranslational modification] 1116391006831 intermolecular recognition site; other site 1116391006832 dimerization interface [polypeptide binding]; other site 1116391006833 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006834 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391006835 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006836 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006837 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006838 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1116391006839 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391006840 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391006841 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391006842 dimerization interface [polypeptide binding]; other site 1116391006843 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1116391006844 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1116391006845 hinge; other site 1116391006846 active site 1116391006847 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1116391006848 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1116391006849 Tetramer interface [polypeptide binding]; other site 1116391006850 active site 1116391006851 FMN-binding site [chemical binding]; other site 1116391006852 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391006853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006854 dimer interface [polypeptide binding]; other site 1116391006855 conserved gate region; other site 1116391006856 putative PBP binding loops; other site 1116391006857 ABC-ATPase subunit interface; other site 1116391006858 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006860 dimer interface [polypeptide binding]; other site 1116391006861 conserved gate region; other site 1116391006862 putative PBP binding loops; other site 1116391006863 ABC-ATPase subunit interface; other site 1116391006864 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006865 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006866 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1116391006867 catalytic residues [active] 1116391006868 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1116391006869 metal-binding site [ion binding] 1116391006870 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1116391006871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391006872 putative substrate translocation pore; other site 1116391006873 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391006874 MarR family; Region: MarR_2; pfam12802 1116391006875 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391006876 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1116391006877 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1116391006878 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1116391006879 P-loop, Walker A motif; other site 1116391006880 Base recognition motif; other site 1116391006881 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1116391006882 S-layer homology domain; Region: SLH; pfam00395 1116391006883 amidase; Provisional; Region: PRK06828 1116391006884 Amidase; Region: Amidase; pfam01425 1116391006885 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391006886 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391006887 metal binding site [ion binding]; metal-binding site 1116391006888 active site 1116391006889 I-site; other site 1116391006890 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1116391006891 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1116391006892 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 1116391006893 dockerin binding interface; other site 1116391006894 S-layer homology domain; Region: SLH; pfam00395 1116391006895 S-layer homology domain; Region: SLH; pfam00395 1116391006896 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391006897 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006898 dimer interface [polypeptide binding]; other site 1116391006899 conserved gate region; other site 1116391006900 ABC-ATPase subunit interface; other site 1116391006901 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006903 dimer interface [polypeptide binding]; other site 1116391006904 ABC-ATPase subunit interface; other site 1116391006905 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006906 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1116391006907 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1116391006908 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1116391006909 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1116391006910 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1116391006911 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391006912 MarR family; Region: MarR; pfam01047 1116391006913 MarR family; Region: MarR_2; cl17246 1116391006914 Pirin; Region: Pirin; pfam02678 1116391006915 Pirin-related protein [General function prediction only]; Region: COG1741 1116391006916 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1116391006917 dimerization interface [polypeptide binding]; other site 1116391006918 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391006919 Histidine kinase; Region: His_kinase; pfam06580 1116391006920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391006921 ATP binding site [chemical binding]; other site 1116391006922 Mg2+ binding site [ion binding]; other site 1116391006923 G-X-G motif; other site 1116391006924 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391006925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391006926 active site 1116391006927 phosphorylation site [posttranslational modification] 1116391006928 intermolecular recognition site; other site 1116391006929 dimerization interface [polypeptide binding]; other site 1116391006930 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391006931 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006932 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1116391006933 SnoaL-like domain; Region: SnoaL_3; pfam13474 1116391006934 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1116391006935 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391006936 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006937 dimer interface [polypeptide binding]; other site 1116391006938 conserved gate region; other site 1116391006939 ABC-ATPase subunit interface; other site 1116391006940 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006942 dimer interface [polypeptide binding]; other site 1116391006943 conserved gate region; other site 1116391006944 putative PBP binding loops; other site 1116391006945 ABC-ATPase subunit interface; other site 1116391006946 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391006947 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391006948 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391006949 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391006950 dimerization interface [polypeptide binding]; other site 1116391006951 Histidine kinase; Region: His_kinase; pfam06580 1116391006952 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391006953 ATP binding site [chemical binding]; other site 1116391006954 Mg2+ binding site [ion binding]; other site 1116391006955 G-X-G motif; other site 1116391006956 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1116391006957 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391006958 active site 1116391006959 phosphorylation site [posttranslational modification] 1116391006960 intermolecular recognition site; other site 1116391006961 dimerization interface [polypeptide binding]; other site 1116391006962 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006963 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391006964 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1116391006965 catalytic core [active] 1116391006966 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1116391006967 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1116391006968 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1116391006969 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1116391006970 catalytic site [active] 1116391006971 Predicted transcriptional regulator [Transcription]; Region: COG2378 1116391006972 HTH domain; Region: HTH_11; pfam08279 1116391006973 WYL domain; Region: WYL; pfam13280 1116391006974 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 1116391006975 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1116391006976 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813 1116391006977 Protein of unknown function (DUF1272); Region: DUF1272; pfam06906 1116391006978 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1116391006979 active site 1116391006980 putative catalytic site [active] 1116391006981 DNA binding site [nucleotide binding] 1116391006982 putative phosphate binding site [ion binding]; other site 1116391006983 metal binding site A [ion binding]; metal-binding site 1116391006984 AP binding site [nucleotide binding]; other site 1116391006985 metal binding site B [ion binding]; metal-binding site 1116391006986 PilZ domain; Region: PilZ; pfam07238 1116391006987 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391006988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006989 dimer interface [polypeptide binding]; other site 1116391006990 conserved gate region; other site 1116391006991 ABC-ATPase subunit interface; other site 1116391006992 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391006993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391006994 dimer interface [polypeptide binding]; other site 1116391006995 conserved gate region; other site 1116391006996 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391006997 ABC-ATPase subunit interface; other site 1116391006998 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391006999 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391007000 dimerization interface [polypeptide binding]; other site 1116391007001 Histidine kinase; Region: His_kinase; pfam06580 1116391007002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391007003 ATP binding site [chemical binding]; other site 1116391007004 Mg2+ binding site [ion binding]; other site 1116391007005 G-X-G motif; other site 1116391007006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391007007 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391007008 active site 1116391007009 phosphorylation site [posttranslational modification] 1116391007010 intermolecular recognition site; other site 1116391007011 dimerization interface [polypeptide binding]; other site 1116391007012 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007013 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391007014 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007015 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391007016 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391007017 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391007018 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1116391007019 NAD(P) binding site [chemical binding]; other site 1116391007020 active site 1116391007021 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1116391007022 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1116391007023 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391007024 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391007025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007026 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007027 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391007028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391007029 dimer interface [polypeptide binding]; other site 1116391007030 phosphorylation site [posttranslational modification] 1116391007031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391007032 ATP binding site [chemical binding]; other site 1116391007033 Mg2+ binding site [ion binding]; other site 1116391007034 G-X-G motif; other site 1116391007035 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1116391007036 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391007037 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391007038 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391007039 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391007040 putative substrate translocation pore; other site 1116391007041 Predicted transcriptional regulators [Transcription]; Region: COG1510 1116391007042 MarR family; Region: MarR_2; cl17246 1116391007043 BCCT family transporter; Region: BCCT; pfam02028 1116391007044 MULE transposase domain; Region: MULE; pfam10551 1116391007045 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1116391007046 Predicted transcriptional regulator [Transcription]; Region: COG4189 1116391007047 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391007048 dimerization interface [polypeptide binding]; other site 1116391007049 putative DNA binding site [nucleotide binding]; other site 1116391007050 putative Zn2+ binding site [ion binding]; other site 1116391007051 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1116391007052 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391007053 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1116391007054 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391007055 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391007056 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391007057 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391007058 dimerization interface [polypeptide binding]; other site 1116391007059 Histidine kinase; Region: His_kinase; pfam06580 1116391007060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391007061 ATP binding site [chemical binding]; other site 1116391007062 Mg2+ binding site [ion binding]; other site 1116391007063 G-X-G motif; other site 1116391007064 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391007065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391007066 active site 1116391007067 phosphorylation site [posttranslational modification] 1116391007068 intermolecular recognition site; other site 1116391007069 dimerization interface [polypeptide binding]; other site 1116391007070 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1116391007071 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391007072 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007073 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007075 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391007076 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007077 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391007078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007079 dimer interface [polypeptide binding]; other site 1116391007080 conserved gate region; other site 1116391007081 ABC-ATPase subunit interface; other site 1116391007082 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391007083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007084 dimer interface [polypeptide binding]; other site 1116391007085 conserved gate region; other site 1116391007086 putative PBP binding loops; other site 1116391007087 ABC-ATPase subunit interface; other site 1116391007088 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391007089 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391007090 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1116391007091 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1116391007092 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1116391007093 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1116391007094 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391007095 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391007096 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007098 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391007099 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391007100 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391007101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007102 putative PBP binding loops; other site 1116391007103 ABC-ATPase subunit interface; other site 1116391007104 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391007105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007106 dimer interface [polypeptide binding]; other site 1116391007107 conserved gate region; other site 1116391007108 putative PBP binding loops; other site 1116391007109 ABC-ATPase subunit interface; other site 1116391007110 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1116391007111 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 1116391007112 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391007113 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391007114 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1116391007115 active site 1116391007116 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1116391007117 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1116391007118 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1116391007119 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1116391007120 substrate binding site [chemical binding]; other site 1116391007121 catalytic residues [active] 1116391007122 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1116391007123 putative hydrophobic ligand binding site [chemical binding]; other site 1116391007124 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391007125 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391007126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007127 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391007128 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391007129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007130 dimer interface [polypeptide binding]; other site 1116391007131 conserved gate region; other site 1116391007132 putative PBP binding loops; other site 1116391007133 ABC-ATPase subunit interface; other site 1116391007134 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391007135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007136 dimer interface [polypeptide binding]; other site 1116391007137 conserved gate region; other site 1116391007138 putative PBP binding loops; other site 1116391007139 ABC-ATPase subunit interface; other site 1116391007140 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1116391007141 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1116391007142 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1116391007143 putative active site [active] 1116391007144 putative catalytic site [active] 1116391007145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391007146 HAMP domain; Region: HAMP; pfam00672 1116391007147 Histidine kinase; Region: His_kinase; pfam06580 1116391007148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391007149 ATP binding site [chemical binding]; other site 1116391007150 Mg2+ binding site [ion binding]; other site 1116391007151 G-X-G motif; other site 1116391007152 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1116391007153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391007154 active site 1116391007155 phosphorylation site [posttranslational modification] 1116391007156 intermolecular recognition site; other site 1116391007157 dimerization interface [polypeptide binding]; other site 1116391007158 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007159 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007160 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391007161 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391007162 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391007163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007164 putative PBP binding loops; other site 1116391007165 dimer interface [polypeptide binding]; other site 1116391007166 ABC-ATPase subunit interface; other site 1116391007167 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391007168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007169 dimer interface [polypeptide binding]; other site 1116391007170 conserved gate region; other site 1116391007171 putative PBP binding loops; other site 1116391007172 ABC-ATPase subunit interface; other site 1116391007173 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1116391007174 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1116391007175 HTH-like domain; Region: HTH_21; pfam13276 1116391007176 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391007177 Integrase core domain; Region: rve; pfam00665 1116391007178 Integrase core domain; Region: rve_3; pfam13683 1116391007179 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391007180 Transposase; Region: HTH_Tnp_1; cl17663 1116391007181 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391007182 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391007183 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1116391007184 Histidine kinase; Region: HisKA_3; pfam07730 1116391007185 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391007186 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391007187 active site 1116391007188 phosphorylation site [posttranslational modification] 1116391007189 intermolecular recognition site; other site 1116391007190 dimerization interface [polypeptide binding]; other site 1116391007191 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391007192 DNA binding residues [nucleotide binding] 1116391007193 dimerization interface [polypeptide binding]; other site 1116391007194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391007195 putative substrate translocation pore; other site 1116391007196 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391007197 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391007198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391007199 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391007200 dimerization interface [polypeptide binding]; other site 1116391007201 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391007202 Coenzyme A binding pocket [chemical binding]; other site 1116391007203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391007204 S-adenosylmethionine binding site [chemical binding]; other site 1116391007205 Protein of unknown function (DUF3895); Region: DUF3895; pfam13034 1116391007206 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1116391007207 DNA-binding site [nucleotide binding]; DNA binding site 1116391007208 RNA-binding motif; other site 1116391007209 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1116391007210 GRAS family transcription factor; Region: GRAS; pfam03514 1116391007211 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391007212 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391007213 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007215 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391007216 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391007217 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391007218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007219 dimer interface [polypeptide binding]; other site 1116391007220 conserved gate region; other site 1116391007221 putative PBP binding loops; other site 1116391007222 ABC-ATPase subunit interface; other site 1116391007223 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391007224 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007225 dimer interface [polypeptide binding]; other site 1116391007226 conserved gate region; other site 1116391007227 putative PBP binding loops; other site 1116391007228 ABC-ATPase subunit interface; other site 1116391007229 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1116391007230 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1116391007231 Predicted transcriptional regulator [Transcription]; Region: COG2378 1116391007232 HTH domain; Region: HTH_11; pfam08279 1116391007233 WYL domain; Region: WYL; pfam13280 1116391007234 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1116391007235 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391007236 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 1116391007237 active site 1116391007238 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391007239 S-adenosylmethionine binding site [chemical binding]; other site 1116391007240 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1116391007241 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391007242 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 1116391007243 dimer interface [polypeptide binding]; other site 1116391007244 putative metal binding site [ion binding]; other site 1116391007245 LysE type translocator; Region: LysE; pfam01810 1116391007246 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1116391007247 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391007248 Coenzyme A binding pocket [chemical binding]; other site 1116391007249 AAA domain; Region: AAA_18; pfam13238 1116391007250 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1116391007251 active site 1116391007252 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 1116391007253 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1116391007254 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391007255 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391007256 ABC transporter; Region: ABC_tran_2; pfam12848 1116391007257 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391007258 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1116391007259 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1116391007260 EamA-like transporter family; Region: EamA; pfam00892 1116391007261 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1116391007262 EamA-like transporter family; Region: EamA; pfam00892 1116391007263 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1116391007264 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1116391007265 DNA binding residues [nucleotide binding] 1116391007266 putative dimer interface [polypeptide binding]; other site 1116391007267 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1116391007268 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1116391007269 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1116391007270 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1116391007271 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391007272 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391007273 active site 1116391007274 catalytic tetrad [active] 1116391007275 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1116391007276 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1116391007277 active site 1116391007278 catalytic triad [active] 1116391007279 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1116391007280 Cytochrome P450; Region: p450; pfam00067 1116391007281 Protein of unknown function (DUF2797); Region: DUF2797; pfam10977 1116391007282 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391007283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391007284 active site 1116391007285 phosphorylation site [posttranslational modification] 1116391007286 intermolecular recognition site; other site 1116391007287 dimerization interface [polypeptide binding]; other site 1116391007288 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391007289 DNA binding site [nucleotide binding] 1116391007290 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391007291 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391007292 dimer interface [polypeptide binding]; other site 1116391007293 phosphorylation site [posttranslational modification] 1116391007294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391007295 ATP binding site [chemical binding]; other site 1116391007296 Mg2+ binding site [ion binding]; other site 1116391007297 G-X-G motif; other site 1116391007298 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1116391007299 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1116391007300 Walker A/P-loop; other site 1116391007301 ATP binding site [chemical binding]; other site 1116391007302 Q-loop/lid; other site 1116391007303 ABC transporter signature motif; other site 1116391007304 Walker B; other site 1116391007305 D-loop; other site 1116391007306 H-loop/switch region; other site 1116391007307 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1116391007308 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1116391007309 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1116391007310 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1116391007311 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1116391007312 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1116391007313 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391007314 dimerization interface [polypeptide binding]; other site 1116391007315 putative DNA binding site [nucleotide binding]; other site 1116391007316 putative Zn2+ binding site [ion binding]; other site 1116391007317 EamA-like transporter family; Region: EamA; pfam00892 1116391007318 EamA-like transporter family; Region: EamA; pfam00892 1116391007319 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391007320 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391007321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391007322 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391007323 putative substrate translocation pore; other site 1116391007324 Predicted transcriptional regulators [Transcription]; Region: COG1695 1116391007325 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1116391007326 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 1116391007327 substrate binding site [chemical binding]; other site 1116391007328 active site 1116391007329 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1116391007330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 1116391007331 DinB superfamily; Region: DinB_2; pfam12867 1116391007332 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1116391007333 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391007334 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 1116391007335 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1116391007336 classical (c) SDRs; Region: SDR_c; cd05233 1116391007337 NAD(P) binding site [chemical binding]; other site 1116391007338 active site 1116391007339 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1116391007340 Predicted transcriptional regulators [Transcription]; Region: COG1695 1116391007341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391007342 salt bridge; other site 1116391007343 non-specific DNA binding site [nucleotide binding]; other site 1116391007344 sequence-specific DNA binding site [nucleotide binding]; other site 1116391007345 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1116391007346 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 1116391007347 NAD(P) binding site [chemical binding]; other site 1116391007348 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1116391007349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391007350 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1116391007351 Coenzyme A binding pocket [chemical binding]; other site 1116391007352 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391007353 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391007354 oligoendopeptidase F; Region: pepF; TIGR00181 1116391007355 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1116391007356 active site 1116391007357 Zn binding site [ion binding]; other site 1116391007358 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1116391007359 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 1116391007360 NAD(P) binding site [chemical binding]; other site 1116391007361 short chain dehydrogenase; Provisional; Region: PRK07677 1116391007362 substrate binding site [chemical binding]; other site 1116391007363 homotetramer interface [polypeptide binding]; other site 1116391007364 active site 1116391007365 homodimer interface [polypeptide binding]; other site 1116391007366 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1116391007367 active site 1116391007368 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391007369 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391007370 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391007371 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391007372 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391007373 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391007374 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391007375 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391007376 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391007377 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391007378 Interdomain contacts; other site 1116391007379 Cytokine receptor motif; other site 1116391007380 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 1116391007381 dockerin binding interface; other site 1116391007382 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391007383 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391007384 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007386 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391007387 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391007388 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391007389 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391007390 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391007391 active site 1116391007392 phosphorylation site [posttranslational modification] 1116391007393 intermolecular recognition site; other site 1116391007394 dimerization interface [polypeptide binding]; other site 1116391007395 LytTr DNA-binding domain; Region: LytTR; pfam04397 1116391007396 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391007397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391007398 ATP binding site [chemical binding]; other site 1116391007399 Mg2+ binding site [ion binding]; other site 1116391007400 G-X-G motif; other site 1116391007401 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1116391007402 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1116391007403 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1116391007404 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391007405 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1116391007406 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1116391007407 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391007408 DNA-binding site [nucleotide binding]; DNA binding site 1116391007409 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391007410 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391007411 homodimer interface [polypeptide binding]; other site 1116391007412 catalytic residue [active] 1116391007413 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 1116391007414 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391007415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007416 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391007417 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007418 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391007419 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1116391007420 NAD(P) binding site [chemical binding]; other site 1116391007421 active site 1116391007422 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1116391007423 conserved cys residue [active] 1116391007424 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391007425 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007426 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391007427 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1116391007428 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391007429 tellurite resistance protein TehB; Provisional; Region: PRK11207 1116391007430 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391007431 S-adenosylmethionine binding site [chemical binding]; other site 1116391007432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 1116391007433 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1116391007434 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391007435 Coenzyme A binding pocket [chemical binding]; other site 1116391007436 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391007437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391007438 NAD(P) binding site [chemical binding]; other site 1116391007439 active site 1116391007440 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1116391007441 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1116391007442 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1116391007443 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1116391007444 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1116391007445 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391007446 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391007447 S-layer homology domain; Region: SLH; pfam00395 1116391007448 S-layer homology domain; Region: SLH; pfam00395 1116391007449 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391007450 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391007451 active site 1116391007452 phosphorylation site [posttranslational modification] 1116391007453 intermolecular recognition site; other site 1116391007454 dimerization interface [polypeptide binding]; other site 1116391007455 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391007456 DNA binding site [nucleotide binding] 1116391007457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391007458 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391007459 dimerization interface [polypeptide binding]; other site 1116391007460 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391007461 dimer interface [polypeptide binding]; other site 1116391007462 phosphorylation site [posttranslational modification] 1116391007463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391007464 ATP binding site [chemical binding]; other site 1116391007465 Mg2+ binding site [ion binding]; other site 1116391007466 G-X-G motif; other site 1116391007467 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1116391007468 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1116391007469 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1116391007470 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1116391007471 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1116391007472 Helix-turn-helix domain; Region: HTH_31; pfam13560 1116391007473 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1116391007474 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1116391007475 NADP binding site [chemical binding]; other site 1116391007476 substrate binding site [chemical binding]; other site 1116391007477 active site 1116391007478 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1116391007479 homotrimer interaction site [polypeptide binding]; other site 1116391007480 putative active site [active] 1116391007481 LysE type translocator; Region: LysE; cl00565 1116391007482 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391007483 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007484 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391007485 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1116391007486 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1116391007487 DNA binding residues [nucleotide binding] 1116391007488 putative dimer interface [polypeptide binding]; other site 1116391007489 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1116391007490 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391007491 NAD(P) binding site [chemical binding]; other site 1116391007492 active site 1116391007493 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1116391007494 short chain dehydrogenase; Provisional; Region: PRK07454 1116391007495 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1116391007496 NADP binding site [chemical binding]; other site 1116391007497 substrate binding site [chemical binding]; other site 1116391007498 active site 1116391007499 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1116391007500 nudix motif; other site 1116391007501 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1116391007502 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391007503 Coenzyme A binding pocket [chemical binding]; other site 1116391007504 EamA-like transporter family; Region: EamA; pfam00892 1116391007505 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1116391007506 EamA-like transporter family; Region: EamA; cl17759 1116391007507 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1116391007508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1116391007509 MOSC domain; Region: MOSC; pfam03473 1116391007510 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1116391007511 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391007512 putative homodimer interface [polypeptide binding]; other site 1116391007513 Sm and related proteins; Region: Sm_like; cl00259 1116391007514 heptamer interface [polypeptide binding]; other site 1116391007515 Sm1 motif; other site 1116391007516 hexamer interface [polypeptide binding]; other site 1116391007517 RNA binding site [nucleotide binding]; other site 1116391007518 Sm2 motif; other site 1116391007519 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 1116391007520 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391007521 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391007522 Transposase; Region: HTH_Tnp_1; cl17663 1116391007523 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391007524 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391007525 HTH-like domain; Region: HTH_21; pfam13276 1116391007526 Integrase core domain; Region: rve; pfam00665 1116391007527 Integrase core domain; Region: rve_2; pfam13333 1116391007528 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 1116391007529 DHH family; Region: DHH; pfam01368 1116391007530 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391007531 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391007532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391007533 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391007534 putative substrate translocation pore; other site 1116391007535 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1116391007536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391007537 active site 1116391007538 phosphorylation site [posttranslational modification] 1116391007539 intermolecular recognition site; other site 1116391007540 dimerization interface [polypeptide binding]; other site 1116391007541 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1116391007542 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391007543 ATP binding site [chemical binding]; other site 1116391007544 Mg2+ binding site [ion binding]; other site 1116391007545 G-X-G motif; other site 1116391007546 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 1116391007547 Citrate transporter; Region: CitMHS; pfam03600 1116391007548 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1116391007549 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1116391007550 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1116391007551 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1116391007552 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1116391007553 active site 1116391007554 substrate-binding site [chemical binding]; other site 1116391007555 metal-binding site [ion binding] 1116391007556 ATP binding site [chemical binding]; other site 1116391007557 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1116391007558 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391007559 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391007560 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391007561 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391007562 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391007563 DNA binding site [nucleotide binding] 1116391007564 domain linker motif; other site 1116391007565 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1116391007566 dimerization interface [polypeptide binding]; other site 1116391007567 ligand binding site [chemical binding]; other site 1116391007568 High-affinity nickel-transport protein; Region: NicO; cl00964 1116391007569 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391007570 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391007571 dimerization interface [polypeptide binding]; other site 1116391007572 Histidine kinase; Region: His_kinase; pfam06580 1116391007573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391007574 ATP binding site [chemical binding]; other site 1116391007575 Mg2+ binding site [ion binding]; other site 1116391007576 G-X-G motif; other site 1116391007577 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391007578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391007579 active site 1116391007580 phosphorylation site [posttranslational modification] 1116391007581 intermolecular recognition site; other site 1116391007582 dimerization interface [polypeptide binding]; other site 1116391007583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007584 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391007585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007586 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391007587 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391007588 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007589 dimer interface [polypeptide binding]; other site 1116391007590 conserved gate region; other site 1116391007591 putative PBP binding loops; other site 1116391007592 ABC-ATPase subunit interface; other site 1116391007593 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391007594 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007595 dimer interface [polypeptide binding]; other site 1116391007596 conserved gate region; other site 1116391007597 putative PBP binding loops; other site 1116391007598 ABC-ATPase subunit interface; other site 1116391007599 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1116391007600 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1116391007601 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1116391007602 PAS domain; Region: PAS; smart00091 1116391007603 PAS domain; Region: PAS_9; pfam13426 1116391007604 putative active site [active] 1116391007605 heme pocket [chemical binding]; other site 1116391007606 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391007607 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391007608 metal binding site [ion binding]; metal-binding site 1116391007609 active site 1116391007610 I-site; other site 1116391007611 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1116391007612 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1116391007613 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1116391007614 PYR/PP interface [polypeptide binding]; other site 1116391007615 dimer interface [polypeptide binding]; other site 1116391007616 TPP binding site [chemical binding]; other site 1116391007617 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1116391007618 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1116391007619 TPP-binding site [chemical binding]; other site 1116391007620 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1116391007621 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1116391007622 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1116391007623 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1116391007624 PYR/PP interface [polypeptide binding]; other site 1116391007625 dimer interface [polypeptide binding]; other site 1116391007626 TPP binding site [chemical binding]; other site 1116391007627 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1116391007628 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1116391007629 TPP-binding site [chemical binding]; other site 1116391007630 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1116391007631 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391007632 putative active site [active] 1116391007633 heme pocket [chemical binding]; other site 1116391007634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391007635 dimer interface [polypeptide binding]; other site 1116391007636 phosphorylation site [posttranslational modification] 1116391007637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391007638 ATP binding site [chemical binding]; other site 1116391007639 Mg2+ binding site [ion binding]; other site 1116391007640 G-X-G motif; other site 1116391007641 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1116391007642 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1116391007643 Walker A/P-loop; other site 1116391007644 ATP binding site [chemical binding]; other site 1116391007645 Q-loop/lid; other site 1116391007646 ABC transporter signature motif; other site 1116391007647 Walker B; other site 1116391007648 D-loop; other site 1116391007649 H-loop/switch region; other site 1116391007650 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1116391007651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007652 dimer interface [polypeptide binding]; other site 1116391007653 conserved gate region; other site 1116391007654 putative PBP binding loops; other site 1116391007655 ABC-ATPase subunit interface; other site 1116391007656 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1116391007657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007658 ABC-ATPase subunit interface; other site 1116391007659 putative PBP binding loops; other site 1116391007660 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1116391007661 NMT1/THI5 like; Region: NMT1; pfam09084 1116391007662 aminotransferase; Validated; Region: PRK07678 1116391007663 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1116391007664 inhibitor-cofactor binding pocket; inhibition site 1116391007665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391007666 catalytic residue [active] 1116391007667 allantoate amidohydrolase; Reviewed; Region: PRK09290 1116391007668 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1116391007669 active site 1116391007670 metal binding site [ion binding]; metal-binding site 1116391007671 dimer interface [polypeptide binding]; other site 1116391007672 mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases); Region: ML_beta-AS_like; cd07568 1116391007673 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1116391007674 putative active site [active] 1116391007675 catalytic triad [active] 1116391007676 multimer interface [polypeptide binding]; other site 1116391007677 dimer interface [polypeptide binding]; other site 1116391007678 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1116391007679 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1116391007680 homodimer interface [polypeptide binding]; other site 1116391007681 active site 1116391007682 FMN binding site [chemical binding]; other site 1116391007683 substrate binding site [chemical binding]; other site 1116391007684 4Fe-4S binding domain; Region: Fer4; pfam00037 1116391007685 phenylhydantoinase; Validated; Region: PRK08323 1116391007686 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1116391007687 tetramer interface [polypeptide binding]; other site 1116391007688 active site 1116391007689 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1116391007690 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1116391007691 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1116391007692 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1116391007693 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1116391007694 NAD(P) binding site [chemical binding]; other site 1116391007695 catalytic residues [active] 1116391007696 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1116391007697 Cache domain; Region: Cache_1; pfam02743 1116391007698 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391007699 dimerization interface [polypeptide binding]; other site 1116391007700 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391007701 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391007702 dimer interface [polypeptide binding]; other site 1116391007703 putative CheW interface [polypeptide binding]; other site 1116391007704 Predicted transcriptional regulators [Transcription]; Region: COG1695 1116391007705 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391007706 putative DNA binding site [nucleotide binding]; other site 1116391007707 putative Zn2+ binding site [ion binding]; other site 1116391007708 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1116391007709 substrate binding site [chemical binding]; other site 1116391007710 active site 1116391007711 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1116391007712 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391007713 S-adenosylmethionine binding site [chemical binding]; other site 1116391007714 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1116391007715 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1116391007716 DNA binding residues [nucleotide binding] 1116391007717 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1116391007718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391007719 S-adenosylmethionine binding site [chemical binding]; other site 1116391007720 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391007721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007722 dimer interface [polypeptide binding]; other site 1116391007723 conserved gate region; other site 1116391007724 putative PBP binding loops; other site 1116391007725 ABC-ATPase subunit interface; other site 1116391007726 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391007727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391007728 dimer interface [polypeptide binding]; other site 1116391007729 conserved gate region; other site 1116391007730 putative PBP binding loops; other site 1116391007731 ABC-ATPase subunit interface; other site 1116391007732 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391007733 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391007734 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1116391007735 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391007736 active site 1116391007737 phosphorylation site [posttranslational modification] 1116391007738 intermolecular recognition site; other site 1116391007739 dimerization interface [polypeptide binding]; other site 1116391007740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007741 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007742 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391007743 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391007744 dimerization interface [polypeptide binding]; other site 1116391007745 Histidine kinase; Region: His_kinase; pfam06580 1116391007746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391007747 ATP binding site [chemical binding]; other site 1116391007748 Mg2+ binding site [ion binding]; other site 1116391007749 G-X-G motif; other site 1116391007750 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391007751 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391007752 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391007753 dimerization interface [polypeptide binding]; other site 1116391007754 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1116391007755 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1116391007756 homodimer interface [polypeptide binding]; other site 1116391007757 substrate-cofactor binding pocket; other site 1116391007758 catalytic residue [active] 1116391007759 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391007760 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 1116391007761 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1116391007762 homodimer interface [polypeptide binding]; other site 1116391007763 substrate-cofactor binding pocket; other site 1116391007764 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391007765 catalytic residue [active] 1116391007766 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1116391007767 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1116391007768 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1116391007769 Walker A/P-loop; other site 1116391007770 ATP binding site [chemical binding]; other site 1116391007771 Q-loop/lid; other site 1116391007772 ABC transporter signature motif; other site 1116391007773 Walker B; other site 1116391007774 D-loop; other site 1116391007775 H-loop/switch region; other site 1116391007776 Predicted transcriptional regulators [Transcription]; Region: COG1725 1116391007777 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391007778 DNA-binding site [nucleotide binding]; DNA binding site 1116391007779 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1116391007780 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1116391007781 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1116391007782 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1116391007783 dimanganese center [ion binding]; other site 1116391007784 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1116391007785 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1116391007786 active site 1116391007787 Pirin-related protein [General function prediction only]; Region: COG1741 1116391007788 Pirin; Region: Pirin; pfam02678 1116391007789 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1116391007790 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1116391007791 aspartate racemase; Region: asp_race; TIGR00035 1116391007792 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391007793 Spore germination protein; Region: Spore_permease; cl17796 1116391007794 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391007795 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391007796 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1116391007797 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391007798 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391007799 dimer interface [polypeptide binding]; other site 1116391007800 phosphorylation site [posttranslational modification] 1116391007801 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391007802 ATP binding site [chemical binding]; other site 1116391007803 Mg2+ binding site [ion binding]; other site 1116391007804 G-X-G motif; other site 1116391007805 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391007806 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391007807 active site 1116391007808 phosphorylation site [posttranslational modification] 1116391007809 intermolecular recognition site; other site 1116391007810 dimerization interface [polypeptide binding]; other site 1116391007811 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1116391007812 Histidine kinase; Region: HisKA_3; pfam07730 1116391007813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391007814 ATP binding site [chemical binding]; other site 1116391007815 Mg2+ binding site [ion binding]; other site 1116391007816 G-X-G motif; other site 1116391007817 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391007818 dimerization interface [polypeptide binding]; other site 1116391007819 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391007820 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391007821 dimer interface [polypeptide binding]; other site 1116391007822 putative CheW interface [polypeptide binding]; other site 1116391007823 L-arabinose isomerase; Provisional; Region: PRK02929 1116391007824 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1116391007825 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1116391007826 trimer interface [polypeptide binding]; other site 1116391007827 putative substrate binding site [chemical binding]; other site 1116391007828 putative metal binding site [ion binding]; other site 1116391007829 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1116391007830 active site 1116391007831 catalytic residues [active] 1116391007832 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 1116391007833 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 1116391007834 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1116391007835 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391007836 Cache domain; Region: Cache_1; pfam02743 1116391007837 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391007838 dimerization interface [polypeptide binding]; other site 1116391007839 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391007840 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391007841 dimer interface [polypeptide binding]; other site 1116391007842 putative CheW interface [polypeptide binding]; other site 1116391007843 Clp protease; Region: CLP_protease; pfam00574 1116391007844 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1116391007845 oligomer interface [polypeptide binding]; other site 1116391007846 active site residues [active] 1116391007847 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391007848 putative DNA binding site [nucleotide binding]; other site 1116391007849 putative Zn2+ binding site [ion binding]; other site 1116391007850 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1116391007851 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 1116391007852 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391007853 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391007854 Initiator Replication protein; Region: Rep_3; pfam01051 1116391007855 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391007856 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391007857 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1116391007858 beta-galactosidase; Region: BGL; TIGR03356 1116391007859 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391007860 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391007861 DNA binding site [nucleotide binding] 1116391007862 domain linker motif; other site 1116391007863 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1116391007864 putative dimerization interface [polypeptide binding]; other site 1116391007865 putative ligand binding site [chemical binding]; other site 1116391007866 DoxX; Region: DoxX; cl17842 1116391007867 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391007868 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391007869 Alginate lyase; Region: Alginate_lyase; pfam05426 1116391007870 Bacterial SH3 domain; Region: SH3_3; pfam08239 1116391007871 Bacterial SH3 domain; Region: SH3_3; pfam08239 1116391007872 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1116391007873 NlpC/P60 family; Region: NLPC_P60; pfam00877 1116391007874 hypothetical protein; Provisional; Region: PRK02237 1116391007875 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1116391007876 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1116391007877 putative ligand binding site [chemical binding]; other site 1116391007878 CHASE3 domain; Region: CHASE3; cl05000 1116391007879 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1116391007880 HAMP domain; Region: HAMP; pfam00672 1116391007881 dimerization interface [polypeptide binding]; other site 1116391007882 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391007883 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391007884 dimer interface [polypeptide binding]; other site 1116391007885 putative CheW interface [polypeptide binding]; other site 1116391007886 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1116391007887 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1116391007888 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1116391007889 PAS domain S-box; Region: sensory_box; TIGR00229 1116391007890 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391007891 putative active site [active] 1116391007892 heme pocket [chemical binding]; other site 1116391007893 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391007894 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391007895 metal binding site [ion binding]; metal-binding site 1116391007896 active site 1116391007897 I-site; other site 1116391007898 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1116391007899 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391007900 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391007901 DNA binding site [nucleotide binding] 1116391007902 domain linker motif; other site 1116391007903 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1116391007904 dimerization interface [polypeptide binding]; other site 1116391007905 ligand binding site [chemical binding]; other site 1116391007906 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391007907 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391007908 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391007909 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391007910 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391007911 active site 1116391007912 phosphorylation site [posttranslational modification] 1116391007913 intermolecular recognition site; other site 1116391007914 dimerization interface [polypeptide binding]; other site 1116391007915 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1116391007916 metal-dependent hydrolase; Provisional; Region: PRK00685 1116391007917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391007918 Coenzyme A binding pocket [chemical binding]; other site 1116391007919 PAS domain S-box; Region: sensory_box; TIGR00229 1116391007920 PAS domain; Region: PAS; smart00091 1116391007921 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391007922 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391007923 metal binding site [ion binding]; metal-binding site 1116391007924 active site 1116391007925 I-site; other site 1116391007926 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1116391007927 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 1116391007928 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391007929 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391007930 Walker A/P-loop; other site 1116391007931 ATP binding site [chemical binding]; other site 1116391007932 Q-loop/lid; other site 1116391007933 ABC transporter signature motif; other site 1116391007934 Walker B; other site 1116391007935 D-loop; other site 1116391007936 H-loop/switch region; other site 1116391007937 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391007938 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391007939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391007940 Walker A/P-loop; other site 1116391007941 ATP binding site [chemical binding]; other site 1116391007942 Q-loop/lid; other site 1116391007943 ABC transporter signature motif; other site 1116391007944 Walker B; other site 1116391007945 D-loop; other site 1116391007946 H-loop/switch region; other site 1116391007947 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1116391007948 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1116391007949 dimer interface [polypeptide binding]; other site 1116391007950 motif 1; other site 1116391007951 active site 1116391007952 motif 2; other site 1116391007953 motif 3; other site 1116391007954 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1116391007955 anticodon binding site; other site 1116391007956 Sulfatase; Region: Sulfatase; pfam00884 1116391007957 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1116391007958 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 1116391007959 GIY-YIG motif/motif A; other site 1116391007960 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1116391007961 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1116391007962 phosphopeptide binding site; other site 1116391007963 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391007964 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1116391007965 DNA binding site [nucleotide binding] 1116391007966 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1116391007967 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1116391007968 hinge; other site 1116391007969 active site 1116391007970 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1116391007971 active site 1116391007972 multimer interface [polypeptide binding]; other site 1116391007973 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1116391007974 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1116391007975 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391007976 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007977 Helix-turn-helix domain; Region: HTH_18; pfam12833 1116391007978 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391007979 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391007980 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391007981 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391007982 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1116391007983 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1116391007984 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1116391007985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391007986 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1116391007987 putative dimerization interface [polypeptide binding]; other site 1116391007988 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1116391007989 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1116391007990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391007991 NAD(P) binding site [chemical binding]; other site 1116391007992 active site 1116391007993 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1116391007994 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1116391007995 putative acyltransferase; Provisional; Region: PRK05790 1116391007996 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1116391007997 dimer interface [polypeptide binding]; other site 1116391007998 active site 1116391007999 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1116391008000 Cytochrome P450; Region: p450; cl12078 1116391008001 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1116391008002 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1116391008003 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1116391008004 Mg++ binding site [ion binding]; other site 1116391008005 putative catalytic motif [active] 1116391008006 substrate binding site [chemical binding]; other site 1116391008007 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391008008 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391008009 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391008010 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391008011 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1116391008012 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1116391008013 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1116391008014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391008015 dimer interface [polypeptide binding]; other site 1116391008016 conserved gate region; other site 1116391008017 ABC-ATPase subunit interface; other site 1116391008018 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1116391008019 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1116391008020 Walker A/P-loop; other site 1116391008021 ATP binding site [chemical binding]; other site 1116391008022 Q-loop/lid; other site 1116391008023 ABC transporter signature motif; other site 1116391008024 Walker B; other site 1116391008025 D-loop; other site 1116391008026 H-loop/switch region; other site 1116391008027 selenophosphate synthetase; Provisional; Region: PRK00943 1116391008028 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1116391008029 dimerization interface [polypeptide binding]; other site 1116391008030 putative ATP binding site [chemical binding]; other site 1116391008031 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 1116391008032 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1116391008033 active site residue [active] 1116391008034 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391008035 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391008036 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 1116391008037 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1116391008038 NAD(P) binding site [chemical binding]; other site 1116391008039 catalytic residues [active] 1116391008040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1116391008041 short chain dehydrogenase; Provisional; Region: PRK06701 1116391008042 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1116391008043 NAD binding site [chemical binding]; other site 1116391008044 metal binding site [ion binding]; metal-binding site 1116391008045 active site 1116391008046 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1116391008047 HlyD family secretion protein; Region: HlyD_3; pfam13437 1116391008048 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1116391008049 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 1116391008050 HlyD family secretion protein; Region: HlyD_3; pfam13437 1116391008051 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1116391008052 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1116391008053 Walker A/P-loop; other site 1116391008054 ATP binding site [chemical binding]; other site 1116391008055 Q-loop/lid; other site 1116391008056 ABC transporter signature motif; other site 1116391008057 Walker B; other site 1116391008058 D-loop; other site 1116391008059 H-loop/switch region; other site 1116391008060 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1116391008061 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1116391008062 FtsX-like permease family; Region: FtsX; pfam02687 1116391008063 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1116391008064 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1116391008065 Chromate transporter; Region: Chromate_transp; pfam02417 1116391008066 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391008067 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391008068 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1116391008069 zinc binding site [ion binding]; other site 1116391008070 putative ligand binding site [chemical binding]; other site 1116391008071 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391008072 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1116391008073 TM-ABC transporter signature motif; other site 1116391008074 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1116391008075 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391008076 Walker A/P-loop; other site 1116391008077 ATP binding site [chemical binding]; other site 1116391008078 Q-loop/lid; other site 1116391008079 ABC transporter signature motif; other site 1116391008080 Walker B; other site 1116391008081 D-loop; other site 1116391008082 H-loop/switch region; other site 1116391008083 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 1116391008084 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391008085 dimerization interface [polypeptide binding]; other site 1116391008086 putative DNA binding site [nucleotide binding]; other site 1116391008087 putative Zn2+ binding site [ion binding]; other site 1116391008088 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1116391008089 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1116391008090 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 1116391008091 active site 1116391008092 Protein of unknown function (DUF962); Region: DUF962; pfam06127 1116391008093 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1116391008094 rod shape-determining protein MreB; Provisional; Region: PRK13927 1116391008095 MreB and similar proteins; Region: MreB_like; cd10225 1116391008096 nucleotide binding site [chemical binding]; other site 1116391008097 Mg binding site [ion binding]; other site 1116391008098 putative protofilament interaction site [polypeptide binding]; other site 1116391008099 RodZ interaction site [polypeptide binding]; other site 1116391008100 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391008101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391008102 active site 1116391008103 phosphorylation site [posttranslational modification] 1116391008104 intermolecular recognition site; other site 1116391008105 dimerization interface [polypeptide binding]; other site 1116391008106 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391008107 DNA binding site [nucleotide binding] 1116391008108 Haemolytic domain; Region: Haemolytic; pfam01809 1116391008109 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1116391008110 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1116391008111 active site 1116391008112 HIGH motif; other site 1116391008113 KMSKS motif; other site 1116391008114 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1116391008115 tRNA binding surface [nucleotide binding]; other site 1116391008116 anticodon binding site; other site 1116391008117 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1116391008118 dimer interface [polypeptide binding]; other site 1116391008119 putative tRNA-binding site [nucleotide binding]; other site 1116391008120 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391008121 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391008122 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391008123 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 1116391008124 glycogen binding site [chemical binding]; other site 1116391008125 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 1116391008126 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 1116391008127 active site 1116391008128 catalytic site [active] 1116391008129 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1116391008130 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1116391008131 metal binding site [ion binding]; metal-binding site 1116391008132 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1116391008133 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1116391008134 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1116391008135 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391008136 ABC-ATPase subunit interface; other site 1116391008137 dimer interface [polypeptide binding]; other site 1116391008138 putative PBP binding regions; other site 1116391008139 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1116391008140 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1116391008141 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1116391008142 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391008143 FeS/SAM binding site; other site 1116391008144 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1116391008145 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1116391008146 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1116391008147 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1116391008148 active site 1116391008149 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1116391008150 nucleophile elbow; other site 1116391008151 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 1116391008152 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1116391008153 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1116391008154 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1116391008155 trimer interface [polypeptide binding]; other site 1116391008156 active site 1116391008157 dimer interface [polypeptide binding]; other site 1116391008158 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1116391008159 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1116391008160 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1116391008161 active site 1116391008162 elongation factor P; Validated; Region: PRK00529 1116391008163 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1116391008164 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1116391008165 RNA binding site [nucleotide binding]; other site 1116391008166 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1116391008167 RNA binding site [nucleotide binding]; other site 1116391008168 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1116391008169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391008170 DNA-binding site [nucleotide binding]; DNA binding site 1116391008171 DRTGG domain; Region: DRTGG; pfam07085 1116391008172 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1116391008173 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1116391008174 active site 2 [active] 1116391008175 active site 1 [active] 1116391008176 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 1116391008177 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1116391008178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391008179 motif II; other site 1116391008180 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 1116391008181 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1116391008182 aspartate kinase; Reviewed; Region: PRK06635 1116391008183 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1116391008184 putative nucleotide binding site [chemical binding]; other site 1116391008185 putative catalytic residues [active] 1116391008186 putative Mg ion binding site [ion binding]; other site 1116391008187 putative aspartate binding site [chemical binding]; other site 1116391008188 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1116391008189 putative allosteric regulatory site; other site 1116391008190 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1116391008191 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1116391008192 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 1116391008193 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 1116391008194 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 1116391008195 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 1116391008196 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1116391008197 NTPase; Region: NTPase_1; cl17478 1116391008198 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 1116391008199 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 1116391008200 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 1116391008201 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 1116391008202 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1116391008203 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1116391008204 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1116391008205 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1116391008206 carboxyltransferase (CT) interaction site; other site 1116391008207 biotinylation site [posttranslational modification]; other site 1116391008208 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1116391008209 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1116391008210 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1116391008211 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1116391008212 Asp23 family; Region: Asp23; pfam03780 1116391008213 Asp23 family; Region: Asp23; pfam03780 1116391008214 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 1116391008215 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1116391008216 putative RNA binding site [nucleotide binding]; other site 1116391008217 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1116391008218 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1116391008219 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1116391008220 homodimer interface [polypeptide binding]; other site 1116391008221 NADP binding site [chemical binding]; other site 1116391008222 substrate binding site [chemical binding]; other site 1116391008223 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1116391008224 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1116391008225 generic binding surface II; other site 1116391008226 generic binding surface I; other site 1116391008227 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1116391008228 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1116391008229 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1116391008230 substrate binding pocket [chemical binding]; other site 1116391008231 chain length determination region; other site 1116391008232 substrate-Mg2+ binding site; other site 1116391008233 catalytic residues [active] 1116391008234 aspartate-rich region 1; other site 1116391008235 active site lid residues [active] 1116391008236 aspartate-rich region 2; other site 1116391008237 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1116391008238 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1116391008239 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1116391008240 RNA binding surface [nucleotide binding]; other site 1116391008241 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1116391008242 arginine repressor; Provisional; Region: PRK04280 1116391008243 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1116391008244 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1116391008245 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1116391008246 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1116391008247 Walker A/P-loop; other site 1116391008248 ATP binding site [chemical binding]; other site 1116391008249 Q-loop/lid; other site 1116391008250 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1116391008251 Q-loop/lid; other site 1116391008252 ABC transporter signature motif; other site 1116391008253 Walker B; other site 1116391008254 D-loop; other site 1116391008255 H-loop/switch region; other site 1116391008256 stage IV sporulation protein B; Region: spore_IV_B; TIGR02860 1116391008257 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1116391008258 protein binding site [polypeptide binding]; other site 1116391008259 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1116391008260 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1116391008261 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391008262 active site 1116391008263 phosphorylation site [posttranslational modification] 1116391008264 intermolecular recognition site; other site 1116391008265 dimerization interface [polypeptide binding]; other site 1116391008266 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1116391008267 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1116391008268 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 1116391008269 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1116391008270 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1116391008271 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1116391008272 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1116391008273 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1116391008274 tetramer interface [polypeptide binding]; other site 1116391008275 TPP-binding site [chemical binding]; other site 1116391008276 heterodimer interface [polypeptide binding]; other site 1116391008277 phosphorylation loop region [posttranslational modification] 1116391008278 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1116391008279 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1116391008280 alpha subunit interface [polypeptide binding]; other site 1116391008281 TPP binding site [chemical binding]; other site 1116391008282 heterodimer interface [polypeptide binding]; other site 1116391008283 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1116391008284 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1116391008285 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1116391008286 E3 interaction surface; other site 1116391008287 lipoyl attachment site [posttranslational modification]; other site 1116391008288 e3 binding domain; Region: E3_binding; pfam02817 1116391008289 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1116391008290 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1116391008291 peptidase T-like protein; Region: PepT-like; TIGR01883 1116391008292 metal binding site [ion binding]; metal-binding site 1116391008293 putative dimer interface [polypeptide binding]; other site 1116391008294 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 1116391008295 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1116391008296 dimer interface [polypeptide binding]; other site 1116391008297 ADP-ribose binding site [chemical binding]; other site 1116391008298 active site 1116391008299 nudix motif; other site 1116391008300 metal binding site [ion binding]; metal-binding site 1116391008301 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 1116391008302 PHP-associated; Region: PHP_C; pfam13263 1116391008303 Integral membrane protein DUF95; Region: DUF95; cl00572 1116391008304 ferric uptake regulator; Provisional; Region: fur; PRK09462 1116391008305 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1116391008306 metal binding site 2 [ion binding]; metal-binding site 1116391008307 putative DNA binding helix; other site 1116391008308 metal binding site 1 [ion binding]; metal-binding site 1116391008309 dimer interface [polypeptide binding]; other site 1116391008310 structural Zn2+ binding site [ion binding]; other site 1116391008311 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1116391008312 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1116391008313 hexamer interface [polypeptide binding]; other site 1116391008314 ligand binding site [chemical binding]; other site 1116391008315 putative active site [active] 1116391008316 NAD(P) binding site [chemical binding]; other site 1116391008317 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1116391008318 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1116391008319 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1116391008320 active site 1116391008321 Int/Topo IB signature motif; other site 1116391008322 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1116391008323 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1116391008324 flagellar operon protein TIGR03826; Region: YvyF 1116391008325 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1116391008326 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1116391008327 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1116391008328 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1116391008329 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1116391008330 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1116391008331 anti sigma factor interaction site; other site 1116391008332 regulatory phosphorylation site [posttranslational modification]; other site 1116391008333 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1116391008334 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391008335 ATP binding site [chemical binding]; other site 1116391008336 Mg2+ binding site [ion binding]; other site 1116391008337 G-X-G motif; other site 1116391008338 sporulation sigma factor SigF; Validated; Region: PRK05572 1116391008339 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391008340 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1116391008341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391008342 DNA binding residues [nucleotide binding] 1116391008343 Domain of unknown function (DUF378); Region: DUF378; pfam04070 1116391008344 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1116391008345 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1116391008346 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391008347 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1116391008348 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1116391008349 active site 1116391008350 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1116391008351 substrate binding site [chemical binding]; other site 1116391008352 catalytic residues [active] 1116391008353 dimer interface [polypeptide binding]; other site 1116391008354 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1116391008355 active site 1116391008356 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1116391008357 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1116391008358 catalytic motif [active] 1116391008359 Zn binding site [ion binding]; other site 1116391008360 RibD C-terminal domain; Region: RibD_C; cl17279 1116391008361 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1116391008362 Lumazine binding domain; Region: Lum_binding; pfam00677 1116391008363 Lumazine binding domain; Region: Lum_binding; pfam00677 1116391008364 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1116391008365 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1116391008366 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1116391008367 dimerization interface [polypeptide binding]; other site 1116391008368 active site 1116391008369 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1116391008370 homopentamer interface [polypeptide binding]; other site 1116391008371 active site 1116391008372 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1116391008373 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1116391008374 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1116391008375 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 1116391008376 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1116391008377 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1116391008378 PAS domain S-box; Region: sensory_box; TIGR00229 1116391008379 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391008380 putative active site [active] 1116391008381 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391008382 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391008383 metal binding site [ion binding]; metal-binding site 1116391008384 active site 1116391008385 I-site; other site 1116391008386 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1116391008387 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1116391008388 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1116391008389 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1116391008390 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1116391008391 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1116391008392 RNA binding surface [nucleotide binding]; other site 1116391008393 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1116391008394 active site 1116391008395 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1116391008396 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1116391008397 catalytic residues [active] 1116391008398 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1116391008399 ResB-like family; Region: ResB; pfam05140 1116391008400 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1116391008401 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 1116391008402 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391008403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391008404 active site 1116391008405 phosphorylation site [posttranslational modification] 1116391008406 intermolecular recognition site; other site 1116391008407 dimerization interface [polypeptide binding]; other site 1116391008408 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391008409 DNA binding site [nucleotide binding] 1116391008410 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391008411 dimerization interface [polypeptide binding]; other site 1116391008412 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1116391008413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391008414 dimer interface [polypeptide binding]; other site 1116391008415 phosphorylation site [posttranslational modification] 1116391008416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391008417 ATP binding site [chemical binding]; other site 1116391008418 Mg2+ binding site [ion binding]; other site 1116391008419 G-X-G motif; other site 1116391008420 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1116391008421 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1116391008422 ligand binding site [chemical binding]; other site 1116391008423 NAD binding site [chemical binding]; other site 1116391008424 dimerization interface [polypeptide binding]; other site 1116391008425 catalytic site [active] 1116391008426 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1116391008427 putative L-serine binding site [chemical binding]; other site 1116391008428 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1116391008429 active site residue [active] 1116391008430 CAAX protease self-immunity; Region: Abi; pfam02517 1116391008431 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1116391008432 NodB motif; other site 1116391008433 active site 1116391008434 catalytic site [active] 1116391008435 metal binding site [ion binding]; metal-binding site 1116391008436 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1116391008437 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1116391008438 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 1116391008439 active site 1116391008440 interdomain interaction site; other site 1116391008441 metal binding site [ion binding]; metal-binding site 1116391008442 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 1116391008443 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1116391008444 Walker A motif; other site 1116391008445 ATP binding site [chemical binding]; other site 1116391008446 Walker B motif; other site 1116391008447 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1116391008448 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1116391008449 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1116391008450 NAD(P) binding site [chemical binding]; other site 1116391008451 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 1116391008452 germination protein YpeB; Region: spore_YpeB; TIGR02889 1116391008453 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1116391008454 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1116391008455 PilZ domain; Region: PilZ; pfam07238 1116391008456 cytidylate kinase; Provisional; Region: cmk; PRK00023 1116391008457 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1116391008458 CMP-binding site; other site 1116391008459 The sites determining sugar specificity; other site 1116391008460 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1116391008461 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1116391008462 putative acyl-acceptor binding pocket; other site 1116391008463 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1116391008464 RNA binding site [nucleotide binding]; other site 1116391008465 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1116391008466 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1116391008467 RNA binding site [nucleotide binding]; other site 1116391008468 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1116391008469 RNA binding site [nucleotide binding]; other site 1116391008470 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1116391008471 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1116391008472 homotetramer interface [polypeptide binding]; other site 1116391008473 FMN binding site [chemical binding]; other site 1116391008474 homodimer contacts [polypeptide binding]; other site 1116391008475 putative active site [active] 1116391008476 putative substrate binding site [chemical binding]; other site 1116391008477 YIEGIA protein; Region: YIEGIA; pfam14045 1116391008478 GTP-binding protein Der; Reviewed; Region: PRK00093 1116391008479 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1116391008480 G1 box; other site 1116391008481 GTP/Mg2+ binding site [chemical binding]; other site 1116391008482 Switch I region; other site 1116391008483 G2 box; other site 1116391008484 Switch II region; other site 1116391008485 G3 box; other site 1116391008486 G4 box; other site 1116391008487 G5 box; other site 1116391008488 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1116391008489 G1 box; other site 1116391008490 GTP/Mg2+ binding site [chemical binding]; other site 1116391008491 Switch I region; other site 1116391008492 G2 box; other site 1116391008493 G3 box; other site 1116391008494 Switch II region; other site 1116391008495 G4 box; other site 1116391008496 G5 box; other site 1116391008497 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1116391008498 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1116391008499 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1116391008500 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1116391008501 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1116391008502 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1116391008503 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1116391008504 catalytic loop [active] 1116391008505 iron binding site [ion binding]; other site 1116391008506 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1116391008507 metal binding triad [ion binding]; metal-binding site 1116391008508 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1116391008509 catalytic loop [active] 1116391008510 iron binding site [ion binding]; other site 1116391008511 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 1116391008512 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1116391008513 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1116391008514 G1 box; other site 1116391008515 GTP/Mg2+ binding site [chemical binding]; other site 1116391008516 G2 box; other site 1116391008517 Switch I region; other site 1116391008518 G3 box; other site 1116391008519 Switch II region; other site 1116391008520 G5 box; other site 1116391008521 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1116391008522 IHF - DNA interface [nucleotide binding]; other site 1116391008523 IHF dimer interface [polypeptide binding]; other site 1116391008524 transcription attenuation protein MtrB; Provisional; Region: PRK13251 1116391008525 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1116391008526 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1116391008527 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391008528 S-adenosylmethionine binding site [chemical binding]; other site 1116391008529 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1116391008530 UbiA prenyltransferase family; Region: UbiA; pfam01040 1116391008531 aromatic acid decarboxylase; Validated; Region: PRK05920 1116391008532 Flavoprotein; Region: Flavoprotein; pfam02441 1116391008533 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1116391008534 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1116391008535 substrate binding pocket [chemical binding]; other site 1116391008536 chain length determination region; other site 1116391008537 substrate-Mg2+ binding site; other site 1116391008538 catalytic residues [active] 1116391008539 aspartate-rich region 1; other site 1116391008540 active site lid residues [active] 1116391008541 aspartate-rich region 2; other site 1116391008542 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1116391008543 active site 1116391008544 multimer interface [polypeptide binding]; other site 1116391008545 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1116391008546 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1116391008547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391008548 S-adenosylmethionine binding site [chemical binding]; other site 1116391008549 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1116391008550 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1116391008551 Tetramer interface [polypeptide binding]; other site 1116391008552 active site 1116391008553 FMN-binding site [chemical binding]; other site 1116391008554 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1116391008555 active site 1116391008556 dimer interface [polypeptide binding]; other site 1116391008557 metal binding site [ion binding]; metal-binding site 1116391008558 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1116391008559 homotrimer interaction site [polypeptide binding]; other site 1116391008560 active site 1116391008561 anthranilate synthase component I; Provisional; Region: PRK13569 1116391008562 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1116391008563 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1116391008564 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1116391008565 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1116391008566 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1116391008567 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1116391008568 active site 1116391008569 ribulose/triose binding site [chemical binding]; other site 1116391008570 phosphate binding site [ion binding]; other site 1116391008571 substrate (anthranilate) binding pocket [chemical binding]; other site 1116391008572 product (indole) binding pocket [chemical binding]; other site 1116391008573 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1116391008574 active site 1116391008575 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1116391008576 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1116391008577 substrate binding site [chemical binding]; other site 1116391008578 active site 1116391008579 catalytic residues [active] 1116391008580 heterodimer interface [polypeptide binding]; other site 1116391008581 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1116391008582 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391008583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391008584 homodimer interface [polypeptide binding]; other site 1116391008585 catalytic residue [active] 1116391008586 prephenate dehydrogenase; Validated; Region: PRK06545 1116391008587 prephenate dehydrogenase; Validated; Region: PRK08507 1116391008588 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1116391008589 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1116391008590 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391008591 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391008592 DNA binding residues [nucleotide binding] 1116391008593 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 1116391008594 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1116391008595 catalytic core [active] 1116391008596 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1116391008597 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1116391008598 trimer interface [polypeptide binding]; other site 1116391008599 putative metal binding site [ion binding]; other site 1116391008600 IDEAL domain; Region: IDEAL; pfam08858 1116391008601 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 1116391008602 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1116391008603 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1116391008604 iron-sulfur cluster [ion binding]; other site 1116391008605 [2Fe-2S] cluster binding site [ion binding]; other site 1116391008606 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 1116391008607 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 1116391008608 interchain domain interface [polypeptide binding]; other site 1116391008609 intrachain domain interface; other site 1116391008610 heme bH binding site [chemical binding]; other site 1116391008611 Qi binding site; other site 1116391008612 heme bL binding site [chemical binding]; other site 1116391008613 Qo binding site; other site 1116391008614 intrachain domain interface; other site 1116391008615 Qi binding site; other site 1116391008616 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 1116391008617 interchain domain interface [polypeptide binding]; other site 1116391008618 Qo binding site; other site 1116391008619 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1116391008620 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1116391008621 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1116391008622 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 1116391008623 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1116391008624 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1116391008625 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1116391008626 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1116391008627 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1116391008628 homodimer interface [polypeptide binding]; other site 1116391008629 metal binding site [ion binding]; metal-binding site 1116391008630 TPR repeat; Region: TPR_11; pfam13414 1116391008631 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1116391008632 TPR motif; other site 1116391008633 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1116391008634 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1116391008635 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1116391008636 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1116391008637 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1116391008638 active site 1116391008639 dimer interfaces [polypeptide binding]; other site 1116391008640 catalytic residues [active] 1116391008641 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1116391008642 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1116391008643 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1116391008644 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1116391008645 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1116391008646 active site 1116391008647 NTP binding site [chemical binding]; other site 1116391008648 metal binding triad [ion binding]; metal-binding site 1116391008649 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1116391008650 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1116391008651 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1116391008652 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1116391008653 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1116391008654 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1116391008655 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1116391008656 active site 1116391008657 oligomerization interface [polypeptide binding]; other site 1116391008658 metal binding site [ion binding]; metal-binding site 1116391008659 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1116391008660 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1116391008661 active site 1116391008662 ATP-binding site [chemical binding]; other site 1116391008663 pantoate-binding site; other site 1116391008664 HXXH motif; other site 1116391008665 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1116391008666 tetramerization interface [polypeptide binding]; other site 1116391008667 active site 1116391008668 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1116391008669 binding surface 1116391008670 TPR repeat; Region: TPR_11; pfam13414 1116391008671 TPR motif; other site 1116391008672 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1116391008673 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1116391008674 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1116391008675 active site 1116391008676 catalytic site [active] 1116391008677 substrate binding site [chemical binding]; other site 1116391008678 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1116391008679 ATP binding site [chemical binding]; other site 1116391008680 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1116391008681 putative Mg++ binding site [ion binding]; other site 1116391008682 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1116391008683 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1116391008684 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1116391008685 CoA binding domain; Region: CoA_binding; pfam02629 1116391008686 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1116391008687 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1116391008688 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 1116391008689 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1116391008690 active site 1116391008691 putative substrate binding pocket [chemical binding]; other site 1116391008692 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1116391008693 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1116391008694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391008695 Walker A motif; other site 1116391008696 ATP binding site [chemical binding]; other site 1116391008697 Walker B motif; other site 1116391008698 arginine finger; other site 1116391008699 Peptidase family M41; Region: Peptidase_M41; pfam01434 1116391008700 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391008701 AMIN domain; Region: AMIN; pfam11741 1116391008702 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1116391008703 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1116391008704 active site 1116391008705 metal binding site [ion binding]; metal-binding site 1116391008706 Sporulation and spore germination; Region: Germane; cl11253 1116391008707 S-layer homology domain; Region: SLH; pfam00395 1116391008708 S-layer homology domain; Region: SLH; pfam00395 1116391008709 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1116391008710 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1116391008711 minor groove reading motif; other site 1116391008712 helix-hairpin-helix signature motif; other site 1116391008713 substrate binding pocket [chemical binding]; other site 1116391008714 active site 1116391008715 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1116391008716 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 1116391008717 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1116391008718 Dynamin family; Region: Dynamin_N; pfam00350 1116391008719 G1 box; other site 1116391008720 GTP/Mg2+ binding site [chemical binding]; other site 1116391008721 G2 box; other site 1116391008722 Switch I region; other site 1116391008723 G3 box; other site 1116391008724 Switch II region; other site 1116391008725 G4 box; other site 1116391008726 G5 box; other site 1116391008727 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1116391008728 Dynamin family; Region: Dynamin_N; pfam00350 1116391008729 G1 box; other site 1116391008730 GTP/Mg2+ binding site [chemical binding]; other site 1116391008731 G2 box; other site 1116391008732 Switch I region; other site 1116391008733 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1116391008734 G3 box; other site 1116391008735 Switch II region; other site 1116391008736 GTP/Mg2+ binding site [chemical binding]; other site 1116391008737 G4 box; other site 1116391008738 G5 box; other site 1116391008739 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391008740 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391008741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391008742 Walker A/P-loop; other site 1116391008743 ATP binding site [chemical binding]; other site 1116391008744 Q-loop/lid; other site 1116391008745 ABC transporter signature motif; other site 1116391008746 Walker B; other site 1116391008747 D-loop; other site 1116391008748 H-loop/switch region; other site 1116391008749 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391008750 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391008751 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1116391008752 Walker A/P-loop; other site 1116391008753 ATP binding site [chemical binding]; other site 1116391008754 Q-loop/lid; other site 1116391008755 ABC transporter signature motif; other site 1116391008756 Walker B; other site 1116391008757 D-loop; other site 1116391008758 H-loop/switch region; other site 1116391008759 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1116391008760 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391008761 G5 domain; Region: G5; pfam07501 1116391008762 Peptidase family M23; Region: Peptidase_M23; pfam01551 1116391008763 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1116391008764 active site 1116391008765 catalytic triad [active] 1116391008766 oxyanion hole [active] 1116391008767 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1116391008768 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1116391008769 Walker A/P-loop; other site 1116391008770 ATP binding site [chemical binding]; other site 1116391008771 Q-loop/lid; other site 1116391008772 ABC transporter signature motif; other site 1116391008773 Walker B; other site 1116391008774 D-loop; other site 1116391008775 H-loop/switch region; other site 1116391008776 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1116391008777 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1116391008778 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1116391008779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391008780 Mg2+ binding site [ion binding]; other site 1116391008781 G-X-G motif; other site 1116391008782 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1116391008783 anchoring element; other site 1116391008784 dimer interface [polypeptide binding]; other site 1116391008785 ATP binding site [chemical binding]; other site 1116391008786 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1116391008787 active site 1116391008788 metal binding site [ion binding]; metal-binding site 1116391008789 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1116391008790 DNA gyrase subunit A; Validated; Region: PRK05560 1116391008791 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1116391008792 CAP-like domain; other site 1116391008793 active site 1116391008794 primary dimer interface [polypeptide binding]; other site 1116391008795 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1116391008796 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1116391008797 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1116391008798 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1116391008799 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1116391008800 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1116391008801 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1116391008802 active site 1116391008803 S-adenosylmethionine binding site [chemical binding]; other site 1116391008804 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1116391008805 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1116391008806 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1116391008807 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391008808 catalytic residue [active] 1116391008809 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391008810 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1116391008811 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 1116391008812 glycogen branching enzyme; Provisional; Region: PRK12313 1116391008813 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1116391008814 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1116391008815 active site 1116391008816 catalytic site [active] 1116391008817 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1116391008818 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1116391008819 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1116391008820 ligand binding site; other site 1116391008821 oligomer interface; other site 1116391008822 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1116391008823 dimer interface [polypeptide binding]; other site 1116391008824 N-terminal domain interface [polypeptide binding]; other site 1116391008825 sulfate 1 binding site; other site 1116391008826 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1116391008827 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1116391008828 ligand binding site; other site 1116391008829 oligomer interface; other site 1116391008830 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1116391008831 dimer interface [polypeptide binding]; other site 1116391008832 N-terminal domain interface [polypeptide binding]; other site 1116391008833 sulfate 1 binding site; other site 1116391008834 glycogen synthase; Provisional; Region: glgA; PRK00654 1116391008835 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1116391008836 ADP-binding pocket [chemical binding]; other site 1116391008837 homodimer interface [polypeptide binding]; other site 1116391008838 GAF domain; Region: GAF; pfam01590 1116391008839 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1116391008840 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391008841 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391008842 dimer interface [polypeptide binding]; other site 1116391008843 phosphorylation site [posttranslational modification] 1116391008844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391008845 ATP binding site [chemical binding]; other site 1116391008846 Mg2+ binding site [ion binding]; other site 1116391008847 G-X-G motif; other site 1116391008848 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1116391008849 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1116391008850 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1116391008851 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 1116391008852 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1116391008853 active site 1116391008854 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 1116391008855 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1116391008856 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391008857 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391008858 active site 1116391008859 phosphorylation site [posttranslational modification] 1116391008860 intermolecular recognition site; other site 1116391008861 dimerization interface [polypeptide binding]; other site 1116391008862 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391008863 DNA binding site [nucleotide binding] 1116391008864 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1116391008865 active site clefts [active] 1116391008866 zinc binding site [ion binding]; other site 1116391008867 dimer interface [polypeptide binding]; other site 1116391008868 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1116391008869 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1116391008870 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1116391008871 active site 1116391008872 Zn binding site [ion binding]; other site 1116391008873 Spore germination protein; Region: Spore_permease; cl17796 1116391008874 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391008875 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391008876 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1116391008877 NMT1-like family; Region: NMT1_2; pfam13379 1116391008878 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1116391008879 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1116391008880 Walker A/P-loop; other site 1116391008881 ATP binding site [chemical binding]; other site 1116391008882 Q-loop/lid; other site 1116391008883 ABC transporter signature motif; other site 1116391008884 Walker B; other site 1116391008885 D-loop; other site 1116391008886 H-loop/switch region; other site 1116391008887 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1116391008888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391008889 dimer interface [polypeptide binding]; other site 1116391008890 conserved gate region; other site 1116391008891 putative PBP binding loops; other site 1116391008892 ABC-ATPase subunit interface; other site 1116391008893 Predicted membrane protein [Function unknown]; Region: COG4129 1116391008894 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1116391008895 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1116391008896 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1116391008897 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 1116391008898 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1116391008899 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1116391008900 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1116391008901 protein binding site [polypeptide binding]; other site 1116391008902 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1116391008903 Catalytic dyad [active] 1116391008904 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391008905 DNA mismatch repair protein MutL; Region: mutl; TIGR00585 1116391008906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391008907 ATP binding site [chemical binding]; other site 1116391008908 Mg2+ binding site [ion binding]; other site 1116391008909 G-X-G motif; other site 1116391008910 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1116391008911 ATP binding site [chemical binding]; other site 1116391008912 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1116391008913 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1116391008914 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391008915 S-adenosylmethionine binding site [chemical binding]; other site 1116391008916 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1116391008917 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1116391008918 bacterial Hfq-like; Region: Hfq; cd01716 1116391008919 hexamer interface [polypeptide binding]; other site 1116391008920 Sm1 motif; other site 1116391008921 RNA binding site [nucleotide binding]; other site 1116391008922 Sm2 motif; other site 1116391008923 Transglycosylase; Region: Transgly; pfam00912 1116391008924 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1116391008925 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1116391008926 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1116391008927 active site 1116391008928 Esterase/lipase [General function prediction only]; Region: COG1647 1116391008929 PGAP1-like protein; Region: PGAP1; pfam07819 1116391008930 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1116391008931 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391008932 active site 1116391008933 metal binding site [ion binding]; metal-binding site 1116391008934 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1116391008935 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1116391008936 putative active site [active] 1116391008937 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1116391008938 short chain dehydrogenase; Provisional; Region: PRK06701 1116391008939 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1116391008940 NAD binding site [chemical binding]; other site 1116391008941 metal binding site [ion binding]; metal-binding site 1116391008942 active site 1116391008943 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1116391008944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391008945 motif II; other site 1116391008946 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1116391008947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391008948 Walker A motif; other site 1116391008949 ATP binding site [chemical binding]; other site 1116391008950 Walker B motif; other site 1116391008951 arginine finger; other site 1116391008952 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1116391008953 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1116391008954 HflX GTPase family; Region: HflX; cd01878 1116391008955 G1 box; other site 1116391008956 GTP/Mg2+ binding site [chemical binding]; other site 1116391008957 Switch I region; other site 1116391008958 G2 box; other site 1116391008959 G3 box; other site 1116391008960 Switch II region; other site 1116391008961 G4 box; other site 1116391008962 G5 box; other site 1116391008963 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1116391008964 Aluminium resistance protein; Region: Alum_res; pfam06838 1116391008965 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1116391008966 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1116391008967 DNA binding residues [nucleotide binding] 1116391008968 putative dimer interface [polypeptide binding]; other site 1116391008969 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1116391008970 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1116391008971 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1116391008972 LexA repressor; Validated; Region: PRK00215 1116391008973 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391008974 putative DNA binding site [nucleotide binding]; other site 1116391008975 putative Zn2+ binding site [ion binding]; other site 1116391008976 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1116391008977 Catalytic site [active] 1116391008978 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391008979 Bacterial protein of unknown function (DUF896); Region: DUF896; cl01722 1116391008980 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391008981 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391008982 active site 1116391008983 catalytic tetrad [active] 1116391008984 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1116391008985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391008986 motif II; other site 1116391008987 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1116391008988 Cupin domain; Region: Cupin_2; cl17218 1116391008989 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1116391008990 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1116391008991 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1116391008992 substrate binding pocket [chemical binding]; other site 1116391008993 dimer interface [polypeptide binding]; other site 1116391008994 inhibitor binding site; inhibition site 1116391008995 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1116391008996 B12 binding site [chemical binding]; other site 1116391008997 cobalt ligand [ion binding]; other site 1116391008998 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1116391008999 ribonuclease Z; Region: RNase_Z; TIGR02651 1116391009000 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1116391009001 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 1116391009002 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1116391009003 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 1116391009004 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1116391009005 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 1116391009006 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1116391009007 putative acyl-acceptor binding pocket; other site 1116391009008 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1116391009009 phytoene desaturase; Region: crtI_fam; TIGR02734 1116391009010 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1116391009011 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1116391009012 DXD motif; other site 1116391009013 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1116391009014 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 1116391009015 putative acyl-acceptor binding pocket; other site 1116391009016 Protein of unknown function (DUF422); Region: DUF422; cl00991 1116391009017 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1116391009018 active site lid residues [active] 1116391009019 substrate binding pocket [chemical binding]; other site 1116391009020 catalytic residues [active] 1116391009021 substrate-Mg2+ binding site; other site 1116391009022 aspartate-rich region 1; other site 1116391009023 aspartate-rich region 2; other site 1116391009024 phytoene desaturase; Region: crtI_fam; TIGR02734 1116391009025 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1116391009026 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1116391009027 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1116391009028 phytoene desaturase; Region: crtI_fam; TIGR02734 1116391009029 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 1116391009030 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1116391009031 ATP binding site [chemical binding]; other site 1116391009032 putative Mg++ binding site [ion binding]; other site 1116391009033 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1116391009034 nucleotide binding region [chemical binding]; other site 1116391009035 ATP-binding site [chemical binding]; other site 1116391009036 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 1116391009037 RNase_H superfamily; Region: RNase_H_2; pfam13482 1116391009038 active site 1116391009039 substrate binding site [chemical binding]; other site 1116391009040 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1116391009041 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 1116391009042 putative DNA binding site [nucleotide binding]; other site 1116391009043 catalytic residue [active] 1116391009044 putative H2TH interface [polypeptide binding]; other site 1116391009045 putative catalytic residues [active] 1116391009046 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1116391009047 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1116391009048 AP endonuclease family 2; Region: AP2Ec; smart00518 1116391009049 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1116391009050 AP (apurinic/apyrimidinic) site pocket; other site 1116391009051 DNA interaction; other site 1116391009052 Metal-binding active site; metal-binding site 1116391009053 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1116391009054 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391009055 Walker A/P-loop; other site 1116391009056 ATP binding site [chemical binding]; other site 1116391009057 Q-loop/lid; other site 1116391009058 ABC transporter signature motif; other site 1116391009059 Walker B; other site 1116391009060 D-loop; other site 1116391009061 H-loop/switch region; other site 1116391009062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391009063 S-adenosylmethionine binding site [chemical binding]; other site 1116391009064 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1116391009065 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391009066 S-adenosylmethionine binding site [chemical binding]; other site 1116391009067 AAA domain; Region: AAA_31; pfam13614 1116391009068 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1116391009069 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1116391009070 Walker A motif; other site 1116391009071 hexamer interface [polypeptide binding]; other site 1116391009072 ATP binding site [chemical binding]; other site 1116391009073 Walker B motif; other site 1116391009074 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1116391009075 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1116391009076 TadE-like protein; Region: TadE; pfam07811 1116391009077 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1116391009078 phosphopeptide binding site; other site 1116391009079 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1116391009080 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1116391009081 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1116391009082 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1116391009083 metal binding site [ion binding]; metal-binding site 1116391009084 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1116391009085 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391009086 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391009087 ABC transporter; Region: ABC_tran_2; pfam12848 1116391009088 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391009089 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1116391009090 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391009091 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391009092 ABC transporter; Region: ABC_tran_2; pfam12848 1116391009093 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391009094 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1116391009095 catalytic residues [active] 1116391009096 Kinase associated protein B; Region: KapB; pfam08810 1116391009097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391009098 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391009099 ATP binding site [chemical binding]; other site 1116391009100 Mg2+ binding site [ion binding]; other site 1116391009101 G-X-G motif; other site 1116391009102 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391009103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391009104 active site 1116391009105 phosphorylation site [posttranslational modification] 1116391009106 intermolecular recognition site; other site 1116391009107 dimerization interface [polypeptide binding]; other site 1116391009108 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391009109 DNA binding residues [nucleotide binding] 1116391009110 dimerization interface [polypeptide binding]; other site 1116391009111 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391009112 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391009113 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391009114 Predicted membrane protein [Function unknown]; Region: COG2860 1116391009115 UPF0126 domain; Region: UPF0126; pfam03458 1116391009116 UPF0126 domain; Region: UPF0126; pfam03458 1116391009117 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 1116391009118 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1116391009119 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391009120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391009121 active site 1116391009122 phosphorylation site [posttranslational modification] 1116391009123 intermolecular recognition site; other site 1116391009124 dimerization interface [polypeptide binding]; other site 1116391009125 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391009126 DNA binding site [nucleotide binding] 1116391009127 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391009128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391009129 dimerization interface [polypeptide binding]; other site 1116391009130 putative DNA binding site [nucleotide binding]; other site 1116391009131 putative Zn2+ binding site [ion binding]; other site 1116391009132 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1116391009133 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1116391009134 ATP-grasp domain; Region: ATP-grasp; pfam02222 1116391009135 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1116391009136 Predicted membrane protein [Function unknown]; Region: COG4682 1116391009137 yiaA/B two helix domain; Region: YiaAB; pfam05360 1116391009138 yiaA/B two helix domain; Region: YiaAB; pfam05360 1116391009139 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 1116391009140 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1116391009141 active site 1116391009142 metal binding site [ion binding]; metal-binding site 1116391009143 homotetramer interface [polypeptide binding]; other site 1116391009144 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 1116391009145 S-formylglutathione hydrolase; Region: PLN02442 1116391009146 Putative esterase; Region: Esterase; pfam00756 1116391009147 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1116391009148 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1116391009149 substrate binding site [chemical binding]; other site 1116391009150 Predicted ATPase [General function prediction only]; Region: COG3899 1116391009151 AAA ATPase domain; Region: AAA_16; pfam13191 1116391009152 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1116391009153 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1116391009154 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391009155 TIGR01777 family protein; Region: yfcH 1116391009156 NAD(P) binding site [chemical binding]; other site 1116391009157 active site 1116391009158 DNA topoisomerase III; Provisional; Region: PRK07726 1116391009159 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1116391009160 active site 1116391009161 putative interdomain interaction site [polypeptide binding]; other site 1116391009162 putative metal-binding site [ion binding]; other site 1116391009163 putative nucleotide binding site [chemical binding]; other site 1116391009164 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1116391009165 domain I; other site 1116391009166 DNA binding groove [nucleotide binding] 1116391009167 phosphate binding site [ion binding]; other site 1116391009168 domain II; other site 1116391009169 domain III; other site 1116391009170 nucleotide binding site [chemical binding]; other site 1116391009171 catalytic site [active] 1116391009172 domain IV; other site 1116391009173 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1116391009174 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391009175 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391009176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391009177 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391009178 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391009179 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391009180 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391009181 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391009182 active site 1116391009183 catalytic tetrad [active] 1116391009184 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391009185 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1116391009186 active site 1116391009187 Predicted transcriptional regulator [Transcription]; Region: COG2378 1116391009188 HTH domain; Region: HTH_11; pfam08279 1116391009189 WYL domain; Region: WYL; pfam13280 1116391009190 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1116391009191 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1116391009192 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1116391009193 putative NAD(P) binding site [chemical binding]; other site 1116391009194 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391009195 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391009196 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391009197 dimerization interface [polypeptide binding]; other site 1116391009198 putative DNA binding site [nucleotide binding]; other site 1116391009199 putative Zn2+ binding site [ion binding]; other site 1116391009200 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1116391009201 hydrophobic ligand binding site; other site 1116391009202 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1116391009203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391009204 S-adenosylmethionine binding site [chemical binding]; other site 1116391009205 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1116391009206 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1116391009207 putative active site [active] 1116391009208 catalytic triad [active] 1116391009209 putative dimer interface [polypeptide binding]; other site 1116391009210 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1116391009211 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1116391009212 E-class dimer interface [polypeptide binding]; other site 1116391009213 P-class dimer interface [polypeptide binding]; other site 1116391009214 active site 1116391009215 Cu2+ binding site [ion binding]; other site 1116391009216 Zn2+ binding site [ion binding]; other site 1116391009217 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391009218 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391009219 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391009220 dimerization interface [polypeptide binding]; other site 1116391009221 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1116391009222 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1116391009223 GDP-binding site [chemical binding]; other site 1116391009224 ACT binding site; other site 1116391009225 IMP binding site; other site 1116391009226 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1116391009227 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1116391009228 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1116391009229 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1116391009230 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1116391009231 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425 1116391009232 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1116391009233 metal ion-dependent adhesion site (MIDAS); other site 1116391009234 regulatory ATPase RavA; Provisional; Region: PRK13531 1116391009235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391009236 Walker A motif; other site 1116391009237 ATP binding site [chemical binding]; other site 1116391009238 Walker B motif; other site 1116391009239 arginine finger; other site 1116391009240 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1116391009241 catalytic residues [active] 1116391009242 dimer interface [polypeptide binding]; other site 1116391009243 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1116391009244 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1116391009245 Ligand Binding Site [chemical binding]; other site 1116391009246 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1116391009247 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1116391009248 dimerization interface [polypeptide binding]; other site 1116391009249 ligand binding site [chemical binding]; other site 1116391009250 NADP binding site [chemical binding]; other site 1116391009251 catalytic site [active] 1116391009252 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1116391009253 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1116391009254 Walker A/P-loop; other site 1116391009255 ATP binding site [chemical binding]; other site 1116391009256 Q-loop/lid; other site 1116391009257 ABC transporter signature motif; other site 1116391009258 Walker B; other site 1116391009259 D-loop; other site 1116391009260 H-loop/switch region; other site 1116391009261 FtsX-like permease family; Region: FtsX; pfam02687 1116391009262 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391009263 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1116391009264 acyl-activating enzyme (AAE) consensus motif; other site 1116391009265 AMP binding site [chemical binding]; other site 1116391009266 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391009267 Condensation domain; Region: Condensation; pfam00668 1116391009268 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391009269 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391009270 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1116391009271 acyl-activating enzyme (AAE) consensus motif; other site 1116391009272 AMP binding site [chemical binding]; other site 1116391009273 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391009274 Condensation domain; Region: Condensation; pfam00668 1116391009275 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391009276 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391009277 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391009278 acyl-activating enzyme (AAE) consensus motif; other site 1116391009279 AMP binding site [chemical binding]; other site 1116391009280 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391009281 Condensation domain; Region: Condensation; pfam00668 1116391009282 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391009283 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391009284 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391009285 acyl-activating enzyme (AAE) consensus motif; other site 1116391009286 AMP binding site [chemical binding]; other site 1116391009287 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391009288 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1116391009289 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391009290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391009291 active site 1116391009292 phosphorylation site [posttranslational modification] 1116391009293 intermolecular recognition site; other site 1116391009294 dimerization interface [polypeptide binding]; other site 1116391009295 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391009296 DNA binding site [nucleotide binding] 1116391009297 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391009298 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391009299 ATP binding site [chemical binding]; other site 1116391009300 Mg2+ binding site [ion binding]; other site 1116391009301 G-X-G motif; other site 1116391009302 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391009303 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391009304 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1116391009305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391009306 non-specific DNA binding site [nucleotide binding]; other site 1116391009307 salt bridge; other site 1116391009308 sequence-specific DNA binding site [nucleotide binding]; other site 1116391009309 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1116391009310 Class II fumarases; Region: Fumarase_classII; cd01362 1116391009311 active site 1116391009312 tetramer interface [polypeptide binding]; other site 1116391009313 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1116391009314 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 1116391009315 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1116391009316 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1116391009317 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1116391009318 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1116391009319 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1116391009320 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1116391009321 ATP binding site [chemical binding]; other site 1116391009322 Walker A motif; other site 1116391009323 hexamer interface [polypeptide binding]; other site 1116391009324 Walker B motif; other site 1116391009325 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1116391009326 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1116391009327 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1116391009328 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391009329 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1116391009330 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391009331 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391009332 Peptidase family M23; Region: Peptidase_M23; pfam01551 1116391009333 H+ Antiporter protein; Region: 2A0121; TIGR00900 1116391009334 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1116391009335 active site 1116391009336 putative interdomain interaction site [polypeptide binding]; other site 1116391009337 putative metal-binding site [ion binding]; other site 1116391009338 putative nucleotide binding site [chemical binding]; other site 1116391009339 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 1116391009340 domain I; other site 1116391009341 DNA binding groove [nucleotide binding] 1116391009342 phosphate binding site [ion binding]; other site 1116391009343 domain II; other site 1116391009344 domain III; other site 1116391009345 nucleotide binding site [chemical binding]; other site 1116391009346 catalytic site [active] 1116391009347 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1116391009348 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1116391009349 HAMP domain; Region: HAMP; pfam00672 1116391009350 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391009351 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391009352 dimer interface [polypeptide binding]; other site 1116391009353 putative CheW interface [polypeptide binding]; other site 1116391009354 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1116391009355 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1116391009356 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1116391009357 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1116391009358 metal binding site 2 [ion binding]; metal-binding site 1116391009359 putative DNA binding helix; other site 1116391009360 metal binding site 1 [ion binding]; metal-binding site 1116391009361 dimer interface [polypeptide binding]; other site 1116391009362 structural Zn2+ binding site [ion binding]; other site 1116391009363 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391009364 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1116391009365 substrate binding pocket [chemical binding]; other site 1116391009366 membrane-bound complex binding site; other site 1116391009367 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1116391009368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391009369 dimer interface [polypeptide binding]; other site 1116391009370 conserved gate region; other site 1116391009371 putative PBP binding loops; other site 1116391009372 ABC-ATPase subunit interface; other site 1116391009373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391009374 dimer interface [polypeptide binding]; other site 1116391009375 conserved gate region; other site 1116391009376 putative PBP binding loops; other site 1116391009377 ABC-ATPase subunit interface; other site 1116391009378 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1116391009379 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1116391009380 Walker A/P-loop; other site 1116391009381 ATP binding site [chemical binding]; other site 1116391009382 Q-loop/lid; other site 1116391009383 ABC transporter signature motif; other site 1116391009384 Walker B; other site 1116391009385 D-loop; other site 1116391009386 H-loop/switch region; other site 1116391009387 TOBE domain; Region: TOBE_2; pfam08402 1116391009388 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1116391009389 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1116391009390 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 1116391009391 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 1116391009392 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1116391009393 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1116391009394 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391009395 substrate binding pocket [chemical binding]; other site 1116391009396 membrane-bound complex binding site; other site 1116391009397 hinge residues; other site 1116391009398 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1116391009399 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1116391009400 active site 1116391009401 dimer interface [polypeptide binding]; other site 1116391009402 non-prolyl cis peptide bond; other site 1116391009403 insertion regions; other site 1116391009404 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1116391009405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391009406 dimer interface [polypeptide binding]; other site 1116391009407 conserved gate region; other site 1116391009408 putative PBP binding loops; other site 1116391009409 ABC-ATPase subunit interface; other site 1116391009410 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1116391009411 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1116391009412 Walker A/P-loop; other site 1116391009413 ATP binding site [chemical binding]; other site 1116391009414 Q-loop/lid; other site 1116391009415 ABC transporter signature motif; other site 1116391009416 Walker B; other site 1116391009417 D-loop; other site 1116391009418 H-loop/switch region; other site 1116391009419 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1116391009420 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1116391009421 Walker A/P-loop; other site 1116391009422 ATP binding site [chemical binding]; other site 1116391009423 Q-loop/lid; other site 1116391009424 ABC transporter signature motif; other site 1116391009425 Walker B; other site 1116391009426 D-loop; other site 1116391009427 H-loop/switch region; other site 1116391009428 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1116391009429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391009430 dimer interface [polypeptide binding]; other site 1116391009431 conserved gate region; other site 1116391009432 putative PBP binding loops; other site 1116391009433 ABC-ATPase subunit interface; other site 1116391009434 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1116391009435 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391009436 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391009437 active site 1116391009438 catalytic tetrad [active] 1116391009439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391009440 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391009441 putative substrate translocation pore; other site 1116391009442 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1116391009443 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391009444 substrate binding pocket [chemical binding]; other site 1116391009445 membrane-bound complex binding site; other site 1116391009446 hinge residues; other site 1116391009447 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1116391009448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391009449 dimer interface [polypeptide binding]; other site 1116391009450 conserved gate region; other site 1116391009451 ABC-ATPase subunit interface; other site 1116391009452 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1116391009453 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1116391009454 Walker A/P-loop; other site 1116391009455 ATP binding site [chemical binding]; other site 1116391009456 Q-loop/lid; other site 1116391009457 ABC transporter signature motif; other site 1116391009458 Walker B; other site 1116391009459 D-loop; other site 1116391009460 H-loop/switch region; other site 1116391009461 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1116391009462 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1116391009463 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1116391009464 metal binding site [ion binding]; metal-binding site 1116391009465 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 1116391009466 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1116391009467 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391009468 Walker A/P-loop; other site 1116391009469 ATP binding site [chemical binding]; other site 1116391009470 Q-loop/lid; other site 1116391009471 ABC transporter signature motif; other site 1116391009472 Walker B; other site 1116391009473 D-loop; other site 1116391009474 H-loop/switch region; other site 1116391009475 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1116391009476 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1116391009477 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1116391009478 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1116391009479 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1116391009480 Transposase domain (DUF772); Region: DUF772; pfam05598 1116391009481 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1116391009482 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1116391009483 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1116391009484 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1116391009485 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1116391009486 AAA domain; Region: AAA_18; pfam13238 1116391009487 ATP-binding site [chemical binding]; other site 1116391009488 Sugar specificity; other site 1116391009489 Pyrimidine base specificity; other site 1116391009490 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1116391009491 classical (c) SDRs; Region: SDR_c; cd05233 1116391009492 NAD(P) binding site [chemical binding]; other site 1116391009493 active site 1116391009494 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1116391009495 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1116391009496 Ca binding site [ion binding]; other site 1116391009497 active site 1116391009498 catalytic site [active] 1116391009499 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1116391009500 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1116391009501 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1116391009502 dimer interface [polypeptide binding]; other site 1116391009503 active site 1116391009504 metal binding site [ion binding]; metal-binding site 1116391009505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391009506 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391009507 putative substrate translocation pore; other site 1116391009508 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 1116391009509 nucleotide binding site/active site [active] 1116391009510 HIT family signature motif; other site 1116391009511 catalytic residue [active] 1116391009512 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391009513 Coenzyme A binding pocket [chemical binding]; other site 1116391009514 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 1116391009515 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1116391009516 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391009517 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1116391009518 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1116391009519 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1116391009520 active site 1116391009521 active site 1116391009522 catalytic residues [active] 1116391009523 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 1116391009524 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1116391009525 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391009526 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391009527 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1116391009528 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 1116391009529 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1116391009530 dimerization interface [polypeptide binding]; other site 1116391009531 mannose binding site [chemical binding]; other site 1116391009532 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1116391009533 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391009534 DNA-binding site [nucleotide binding]; DNA binding site 1116391009535 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1116391009536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391009537 D-galactonate transporter; Region: 2A0114; TIGR00893 1116391009538 putative substrate translocation pore; other site 1116391009539 transketolase; Reviewed; Region: PRK05899 1116391009540 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1116391009541 TPP-binding site [chemical binding]; other site 1116391009542 dimer interface [polypeptide binding]; other site 1116391009543 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1116391009544 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1116391009545 PYR/PP interface [polypeptide binding]; other site 1116391009546 dimer interface [polypeptide binding]; other site 1116391009547 TPP binding site [chemical binding]; other site 1116391009548 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1116391009549 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1116391009550 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391009551 NAD(P) binding site [chemical binding]; other site 1116391009552 active site 1116391009553 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1116391009554 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1116391009555 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391009556 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391009557 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391009558 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1116391009559 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1116391009560 Walker A/P-loop; other site 1116391009561 ATP binding site [chemical binding]; other site 1116391009562 Q-loop/lid; other site 1116391009563 ABC transporter signature motif; other site 1116391009564 Walker B; other site 1116391009565 D-loop; other site 1116391009566 H-loop/switch region; other site 1116391009567 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391009568 ABC-ATPase subunit interface; other site 1116391009569 dimer interface [polypeptide binding]; other site 1116391009570 putative PBP binding regions; other site 1116391009571 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1116391009572 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391009573 ABC-ATPase subunit interface; other site 1116391009574 dimer interface [polypeptide binding]; other site 1116391009575 putative PBP binding regions; other site 1116391009576 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1116391009577 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1116391009578 siderophore binding site; other site 1116391009579 Predicted membrane protein [Function unknown]; Region: COG2364 1116391009580 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1116391009581 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391009582 Coenzyme A binding pocket [chemical binding]; other site 1116391009583 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391009584 MarR family; Region: MarR; pfam01047 1116391009585 DoxX-like family; Region: DoxX_2; pfam13564 1116391009586 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391009587 dimerization interface [polypeptide binding]; other site 1116391009588 putative DNA binding site [nucleotide binding]; other site 1116391009589 putative Zn2+ binding site [ion binding]; other site 1116391009590 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1116391009591 putative hydrophobic ligand binding site [chemical binding]; other site 1116391009592 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1116391009593 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1116391009594 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1116391009595 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1116391009596 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1116391009597 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1116391009598 DNA binding residues [nucleotide binding] 1116391009599 putative dimer interface [polypeptide binding]; other site 1116391009600 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1116391009601 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 1116391009602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391009603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391009604 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1116391009605 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1116391009606 putative NAD(P) binding site [chemical binding]; other site 1116391009607 putative substrate binding site [chemical binding]; other site 1116391009608 catalytic Zn binding site [ion binding]; other site 1116391009609 structural Zn binding site [ion binding]; other site 1116391009610 dimer interface [polypeptide binding]; other site 1116391009611 Uncharacterized conserved protein [Function unknown]; Region: COG4925 1116391009612 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 1116391009613 Helix-turn-helix domain; Region: HTH_17; pfam12728 1116391009614 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391009615 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391009616 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391009617 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1116391009618 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391009619 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1116391009620 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1116391009621 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391009622 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391009623 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391009624 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391009625 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1116391009626 classical (c) SDRs; Region: SDR_c; cd05233 1116391009627 NAD(P) binding site [chemical binding]; other site 1116391009628 active site 1116391009629 galactonate dehydratase; Provisional; Region: PRK14017 1116391009630 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1116391009631 putative active site pocket [active] 1116391009632 putative metal binding site [ion binding]; other site 1116391009633 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1116391009634 Predicted transcriptional regulators [Transcription]; Region: COG1695 1116391009635 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1116391009636 CAAX protease self-immunity; Region: Abi; pfam02517 1116391009637 serine/threonine transporter SstT; Provisional; Region: PRK13628 1116391009638 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1116391009639 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1116391009640 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1116391009641 dimer interface [polypeptide binding]; other site 1116391009642 FMN binding site [chemical binding]; other site 1116391009643 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391009644 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391009645 putative DNA binding site [nucleotide binding]; other site 1116391009646 putative Zn2+ binding site [ion binding]; other site 1116391009647 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1116391009648 catalytic core [active] 1116391009649 Phosphotransferase enzyme family; Region: APH; pfam01636 1116391009650 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1116391009651 active site 1116391009652 substrate binding site [chemical binding]; other site 1116391009653 ATP binding site [chemical binding]; other site 1116391009654 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 1116391009655 DinB superfamily; Region: DinB_2; pfam12867 1116391009656 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 1116391009657 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1116391009658 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1116391009659 RNAase interaction site [polypeptide binding]; other site 1116391009660 Helix-turn-helix domain; Region: HTH_17; pfam12728 1116391009661 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1116391009662 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1116391009663 putative oxidoreductase; Provisional; Region: PRK08275 1116391009664 L-aspartate oxidase; Provisional; Region: PRK06175 1116391009665 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1116391009666 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1116391009667 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1116391009668 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1116391009669 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391009670 membrane-bound complex binding site; other site 1116391009671 hinge residues; other site 1116391009672 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 1116391009673 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1116391009674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391009675 dimer interface [polypeptide binding]; other site 1116391009676 conserved gate region; other site 1116391009677 putative PBP binding loops; other site 1116391009678 ABC-ATPase subunit interface; other site 1116391009679 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391009680 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1116391009681 active site 1116391009682 metal binding site [ion binding]; metal-binding site 1116391009683 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1116391009684 dimer interface [polypeptide binding]; other site 1116391009685 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391009686 ligand binding site [chemical binding]; other site 1116391009687 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391009688 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391009689 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1116391009690 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1116391009691 Methylase of polypeptide chain release factors [Translation, ribosomal structure and biogenesis]; Region: HemK; COG2890 1116391009692 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391009693 S-adenosylmethionine binding site [chemical binding]; other site 1116391009694 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1116391009695 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391009696 Coenzyme A binding pocket [chemical binding]; other site 1116391009697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391009698 S-adenosylmethionine binding site [chemical binding]; other site 1116391009699 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391009700 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391009701 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391009702 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391009703 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391009704 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1116391009705 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1116391009706 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1116391009707 active site 1116391009708 PAS fold; Region: PAS_4; pfam08448 1116391009709 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391009710 putative active site [active] 1116391009711 heme pocket [chemical binding]; other site 1116391009712 PAS domain S-box; Region: sensory_box; TIGR00229 1116391009713 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391009714 putative active site [active] 1116391009715 heme pocket [chemical binding]; other site 1116391009716 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1116391009717 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391009718 putative active site [active] 1116391009719 heme pocket [chemical binding]; other site 1116391009720 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391009721 dimer interface [polypeptide binding]; other site 1116391009722 phosphorylation site [posttranslational modification] 1116391009723 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391009724 ATP binding site [chemical binding]; other site 1116391009725 Mg2+ binding site [ion binding]; other site 1116391009726 G-X-G motif; other site 1116391009727 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391009728 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391009729 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391009730 S-adenosylmethionine binding site [chemical binding]; other site 1116391009731 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391009732 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391009733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391009734 KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592 1116391009735 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1116391009736 putative active site [active] 1116391009737 putative catalytic site [active] 1116391009738 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1116391009739 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1116391009740 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1116391009741 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1116391009742 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391009743 Transposase; Region: HTH_Tnp_1; cl17663 1116391009744 HTH-like domain; Region: HTH_21; pfam13276 1116391009745 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391009746 Integrase core domain; Region: rve; pfam00665 1116391009747 Integrase core domain; Region: rve_3; pfam13683 1116391009748 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 1116391009749 active site 1116391009750 catalytic triad [active] 1116391009751 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1116391009752 catalytic residues [active] 1116391009753 Protein of unknown function (DUF419); Region: DUF419; cl15265 1116391009754 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1116391009755 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1116391009756 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 1116391009757 putative active site [active] 1116391009758 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1116391009759 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1116391009760 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1116391009761 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1116391009762 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1116391009763 metal-binding site 1116391009764 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 1116391009765 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 1116391009766 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111 1116391009767 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1116391009768 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391009769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391009770 active site 1116391009771 phosphorylation site [posttranslational modification] 1116391009772 intermolecular recognition site; other site 1116391009773 dimerization interface [polypeptide binding]; other site 1116391009774 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1116391009775 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1116391009776 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1116391009777 Walker A/P-loop; other site 1116391009778 ATP binding site [chemical binding]; other site 1116391009779 Q-loop/lid; other site 1116391009780 ABC transporter signature motif; other site 1116391009781 Walker B; other site 1116391009782 D-loop; other site 1116391009783 H-loop/switch region; other site 1116391009784 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1116391009785 FAD binding domain; Region: FAD_binding_4; pfam01565 1116391009786 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1116391009787 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391009788 dimer interface [polypeptide binding]; other site 1116391009789 conserved gate region; other site 1116391009790 ABC-ATPase subunit interface; other site 1116391009791 cytosine deaminase; Provisional; Region: PRK09230 1116391009792 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1116391009793 active site 1116391009794 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1116391009795 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1116391009796 NMT1/THI5 like; Region: NMT1; pfam09084 1116391009797 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391009798 substrate binding pocket [chemical binding]; other site 1116391009799 hinge residues; other site 1116391009800 cytosine deaminase; Provisional; Region: PRK09230 1116391009801 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1116391009802 active site 1116391009803 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 1116391009804 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 1116391009805 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1116391009806 active site 1116391009807 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1116391009808 active site 1116391009809 homotetramer interface [polypeptide binding]; other site 1116391009810 allantoinase; Provisional; Region: PRK06189 1116391009811 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1116391009812 active site 1116391009813 allantoate amidohydrolase; Reviewed; Region: PRK09290 1116391009814 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1116391009815 active site 1116391009816 metal binding site [ion binding]; metal-binding site 1116391009817 dimer interface [polypeptide binding]; other site 1116391009818 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1116391009819 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1116391009820 catalytic residue [active] 1116391009821 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 1116391009822 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 1116391009823 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1116391009824 Predicted transcriptional regulators [Transcription]; Region: COG1695 1116391009825 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1116391009826 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1116391009827 NPCBM/NEW2 domain; Region: NPCBM; cl07060 1116391009828 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1116391009829 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 1116391009830 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 1116391009831 4Fe-4S binding domain; Region: Fer4; cl02805 1116391009832 4Fe-4S binding domain; Region: Fer4; pfam00037 1116391009833 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 1116391009834 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1116391009835 dimer interface [polypeptide binding]; other site 1116391009836 PYR/PP interface [polypeptide binding]; other site 1116391009837 TPP binding site [chemical binding]; other site 1116391009838 substrate binding site [chemical binding]; other site 1116391009839 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 1116391009840 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1116391009841 TPP-binding site [chemical binding]; other site 1116391009842 Transposase domain (DUF772); Region: DUF772; pfam05598 1116391009843 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1116391009844 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1116391009845 DoxX-like family; Region: DoxX_2; pfam13564 1116391009846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391009847 Coenzyme A binding pocket [chemical binding]; other site 1116391009848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391009849 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1116391009850 Coenzyme A binding pocket [chemical binding]; other site 1116391009851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391009852 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391009853 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391009854 short chain dehydrogenase; Provisional; Region: PRK06180 1116391009855 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1116391009856 NADP binding site [chemical binding]; other site 1116391009857 active site 1116391009858 steroid binding site; other site 1116391009859 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391009860 MarR family; Region: MarR_2; pfam12802 1116391009861 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1116391009862 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1116391009863 EamA-like transporter family; Region: EamA; pfam00892 1116391009864 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1116391009865 GAF domain; Region: GAF_2; pfam13185 1116391009866 EDD domain protein, DegV family; Region: DegV; TIGR00762 1116391009867 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1116391009868 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1116391009869 EamA-like transporter family; Region: EamA; pfam00892 1116391009870 EamA-like transporter family; Region: EamA; pfam00892 1116391009871 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1116391009872 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1116391009873 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391009874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391009875 active site 1116391009876 phosphorylation site [posttranslational modification] 1116391009877 intermolecular recognition site; other site 1116391009878 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391009879 DNA binding site [nucleotide binding] 1116391009880 peptide synthase; Provisional; Region: PRK12316 1116391009881 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391009882 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1116391009883 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1116391009884 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1116391009885 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1116391009886 putative active site [active] 1116391009887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391009888 NAD(P) binding site [chemical binding]; other site 1116391009889 active site 1116391009890 benzoate transport; Region: 2A0115; TIGR00895 1116391009891 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391009892 putative substrate translocation pore; other site 1116391009893 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1116391009894 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1116391009895 NADP binding site [chemical binding]; other site 1116391009896 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1116391009897 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1116391009898 catalytic residues [active] 1116391009899 FlaG protein; Region: FlaG; pfam03646 1116391009900 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1116391009901 alanine racemase; Reviewed; Region: alr; PRK00053 1116391009902 active site 1116391009903 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1116391009904 dimer interface [polypeptide binding]; other site 1116391009905 substrate binding site [chemical binding]; other site 1116391009906 catalytic residues [active] 1116391009907 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1116391009908 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1116391009909 hexamer interface [polypeptide binding]; other site 1116391009910 ligand binding site [chemical binding]; other site 1116391009911 putative active site [active] 1116391009912 NAD(P) binding site [chemical binding]; other site 1116391009913 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 1116391009914 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1116391009915 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1116391009916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391009917 S-adenosylmethionine binding site [chemical binding]; other site 1116391009918 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1116391009919 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 1116391009920 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 1116391009921 nudix motif; other site 1116391009922 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1116391009923 active site 1116391009924 catalytic residues [active] 1116391009925 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 1116391009926 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1116391009927 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391009928 Coenzyme A binding pocket [chemical binding]; other site 1116391009929 DNA polymerase III subunit epsilon; Validated; Region: PRK05601 1116391009930 beta-D-glucuronidase; Provisional; Region: PRK10150 1116391009931 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1116391009932 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391009933 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1116391009934 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391009935 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391009936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391009937 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1116391009938 putative active site [active] 1116391009939 putative metal binding site [ion binding]; other site 1116391009940 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 1116391009941 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1116391009942 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391009943 non-specific DNA binding site [nucleotide binding]; other site 1116391009944 salt bridge; other site 1116391009945 sequence-specific DNA binding site [nucleotide binding]; other site 1116391009946 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391009947 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1116391009948 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1116391009949 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1116391009950 Substrate binding site; other site 1116391009951 Cupin domain; Region: Cupin_2; cl17218 1116391009952 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1116391009953 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1116391009954 NADP-binding site; other site 1116391009955 homotetramer interface [polypeptide binding]; other site 1116391009956 substrate binding site [chemical binding]; other site 1116391009957 homodimer interface [polypeptide binding]; other site 1116391009958 active site 1116391009959 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1116391009960 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1116391009961 inhibitor-cofactor binding pocket; inhibition site 1116391009962 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391009963 catalytic residue [active] 1116391009964 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1116391009965 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1116391009966 putative trimer interface [polypeptide binding]; other site 1116391009967 putative CoA binding site [chemical binding]; other site 1116391009968 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 1116391009969 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1116391009970 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391009971 non-specific DNA binding site [nucleotide binding]; other site 1116391009972 salt bridge; other site 1116391009973 sequence-specific DNA binding site [nucleotide binding]; other site 1116391009974 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1116391009975 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1116391009976 siderophore binding site; other site 1116391009977 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1116391009978 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391009979 ABC-ATPase subunit interface; other site 1116391009980 dimer interface [polypeptide binding]; other site 1116391009981 putative PBP binding regions; other site 1116391009982 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391009983 ABC-ATPase subunit interface; other site 1116391009984 dimer interface [polypeptide binding]; other site 1116391009985 putative PBP binding regions; other site 1116391009986 Transposase domain (DUF772); Region: DUF772; pfam05598 1116391009987 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1116391009988 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1116391009989 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 1116391009990 substrate binding site [chemical binding]; other site 1116391009991 active site 1116391009992 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1116391009993 dimer interface [polypeptide binding]; other site 1116391009994 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391009995 Cupin domain; Region: Cupin_2; pfam07883 1116391009996 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391009997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391009998 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 1116391009999 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1116391010000 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1116391010001 protein binding site [polypeptide binding]; other site 1116391010002 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391010003 MarR family; Region: MarR; pfam01047 1116391010004 Epoxide hydrolase N terminus; Region: EHN; pfam06441 1116391010005 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1116391010006 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1116391010007 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1116391010008 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1116391010009 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1116391010010 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 1116391010011 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1116391010012 generic binding surface I; other site 1116391010013 generic binding surface II; other site 1116391010014 HD domain; Region: HD; pfam01966 1116391010015 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1116391010016 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1116391010017 beta-galactosidase; Region: BGL; TIGR03356 1116391010018 hypothetical protein; Provisional; Region: PRK12378 1116391010019 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1116391010020 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391010021 Coenzyme A binding pocket [chemical binding]; other site 1116391010022 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1116391010023 Zn2+ binding site [ion binding]; other site 1116391010024 Mg2+ binding site [ion binding]; other site 1116391010025 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1116391010026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391010027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391010028 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881 1116391010029 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1116391010030 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1116391010031 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1116391010032 nucleotide binding region [chemical binding]; other site 1116391010033 ATP-binding site [chemical binding]; other site 1116391010034 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1116391010035 dimer interface [polypeptide binding]; other site 1116391010036 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391010037 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391010038 HTH-like domain; Region: HTH_21; pfam13276 1116391010039 Integrase core domain; Region: rve; pfam00665 1116391010040 Integrase core domain; Region: rve_2; pfam13333 1116391010041 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391010042 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391010043 Transposase; Region: HTH_Tnp_1; cl17663 1116391010044 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391010045 RNA polymerase factor sigma-70; Validated; Region: PRK08241 1116391010046 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391010047 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391010048 DNA binding residues [nucleotide binding] 1116391010049 SnoaL-like domain; Region: SnoaL_2; pfam12680 1116391010050 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 1116391010051 putative hydrophobic ligand binding site [chemical binding]; other site 1116391010052 DoxX-like family; Region: DoxX_2; pfam13564 1116391010053 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1116391010054 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1116391010055 FMN binding site [chemical binding]; other site 1116391010056 active site 1116391010057 substrate binding site [chemical binding]; other site 1116391010058 catalytic residue [active] 1116391010059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391010060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391010061 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1116391010062 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 1116391010063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391010064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391010065 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1116391010066 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1116391010067 NADP binding site [chemical binding]; other site 1116391010068 RibD C-terminal domain; Region: RibD_C; cl17279 1116391010069 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1116391010070 Immunity protein Imm6; Region: Imm6; pfam14434 1116391010071 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1116391010072 active site 1116391010073 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1116391010074 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 1116391010075 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391010076 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391010077 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391010078 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391010079 putative substrate translocation pore; other site 1116391010080 Predicted transcriptional regulators [Transcription]; Region: COG1695 1116391010081 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1116391010082 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1116391010083 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1116391010084 AAA domain; Region: AAA_18; pfam13238 1116391010085 active site 1116391010086 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391010087 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1116391010088 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1116391010089 active site 1116391010090 dimer interface [polypeptide binding]; other site 1116391010091 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1116391010092 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1116391010093 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391010094 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1116391010095 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1116391010096 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1116391010097 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391010098 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010099 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 1116391010100 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1116391010101 active site 1116391010102 amidase; Provisional; Region: PRK06828 1116391010103 Amidase; Region: Amidase; cl11426 1116391010104 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1116391010105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391010106 Coenzyme A binding pocket [chemical binding]; other site 1116391010107 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391010108 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391010109 active site 1116391010110 catalytic tetrad [active] 1116391010111 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1116391010112 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1116391010113 putative substrate binding site [chemical binding]; other site 1116391010114 putative ATP binding site [chemical binding]; other site 1116391010115 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1116391010116 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1116391010117 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1116391010118 active site 1116391010119 DNA binding site [nucleotide binding] 1116391010120 Int/Topo IB signature motif; other site 1116391010121 peptide synthase; Validated; Region: PRK05691 1116391010122 Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109 1116391010123 dimer interface [polypeptide binding]; other site 1116391010124 Citrate synthase; Region: Citrate_synt; pfam00285 1116391010125 active site 1116391010126 citrylCoA binding site [chemical binding]; other site 1116391010127 oxalacetate/citrate binding site [chemical binding]; other site 1116391010128 coenzyme A binding site [chemical binding]; other site 1116391010129 catalytic triad [active] 1116391010130 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1116391010131 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391010132 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391010133 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391010134 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391010135 DNA binding site [nucleotide binding] 1116391010136 domain linker motif; other site 1116391010137 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1116391010138 dimerization interface [polypeptide binding]; other site 1116391010139 ligand binding site [chemical binding]; other site 1116391010140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010141 dimer interface [polypeptide binding]; other site 1116391010142 conserved gate region; other site 1116391010143 putative PBP binding loops; other site 1116391010144 ABC-ATPase subunit interface; other site 1116391010145 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391010146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010147 dimer interface [polypeptide binding]; other site 1116391010148 conserved gate region; other site 1116391010149 putative PBP binding loops; other site 1116391010150 ABC-ATPase subunit interface; other site 1116391010151 Cytochrome c; Region: Cytochrom_C; pfam00034 1116391010152 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1116391010153 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1116391010154 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391010155 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1116391010156 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1116391010157 substrate binding site [chemical binding]; other site 1116391010158 ATP binding site [chemical binding]; other site 1116391010159 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1116391010160 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1116391010161 dimerization interface [polypeptide binding]; other site 1116391010162 ligand binding site [chemical binding]; other site 1116391010163 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391010164 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1116391010165 TM-ABC transporter signature motif; other site 1116391010166 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1116391010167 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1116391010168 TM-ABC transporter signature motif; other site 1116391010169 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1116391010170 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1116391010171 Walker A/P-loop; other site 1116391010172 ATP binding site [chemical binding]; other site 1116391010173 Q-loop/lid; other site 1116391010174 ABC transporter signature motif; other site 1116391010175 Walker B; other site 1116391010176 D-loop; other site 1116391010177 H-loop/switch region; other site 1116391010178 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1116391010179 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1116391010180 Walker A/P-loop; other site 1116391010181 ATP binding site [chemical binding]; other site 1116391010182 Q-loop/lid; other site 1116391010183 ABC transporter signature motif; other site 1116391010184 Walker B; other site 1116391010185 D-loop; other site 1116391010186 H-loop/switch region; other site 1116391010187 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391010188 Spore germination protein; Region: Spore_permease; cl17796 1116391010189 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391010190 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391010191 Predicted membrane protein [Function unknown]; Region: COG2322 1116391010192 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1116391010193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391010194 S-adenosylmethionine binding site [chemical binding]; other site 1116391010195 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1116391010196 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391010197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391010198 DNA binding residues [nucleotide binding] 1116391010199 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1116391010200 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1116391010201 active site 1116391010202 oxyanion hole [active] 1116391010203 catalytic triad [active] 1116391010204 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_5; cd07238 1116391010205 dimer interface [polypeptide binding]; other site 1116391010206 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391010207 DinB superfamily; Region: DinB_2; pfam12867 1116391010208 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 1116391010209 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1116391010210 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1116391010211 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1116391010212 DNA binding residues [nucleotide binding] 1116391010213 putative dimer interface [polypeptide binding]; other site 1116391010214 short chain dehydrogenase; Provisional; Region: PRK06500 1116391010215 classical (c) SDRs; Region: SDR_c; cd05233 1116391010216 NAD(P) binding site [chemical binding]; other site 1116391010217 active site 1116391010218 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391010219 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391010220 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1116391010221 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1116391010222 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1116391010223 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1116391010224 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391010225 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1116391010226 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 1116391010227 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1116391010228 sugar binding site [chemical binding]; other site 1116391010229 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1116391010230 sugar binding site [chemical binding]; other site 1116391010231 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 1116391010232 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1116391010233 beta-D-glucuronidase; Provisional; Region: PRK10150 1116391010234 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1116391010235 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391010236 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1116391010237 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1116391010238 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 1116391010239 putative active site [active] 1116391010240 putative metal binding site [ion binding]; other site 1116391010241 BNR repeat-like domain; Region: BNR_2; pfam13088 1116391010242 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1116391010243 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1116391010244 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 1116391010245 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1116391010246 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1116391010247 inhibitor binding site; inhibition site 1116391010248 active site 1116391010249 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1116391010250 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1116391010251 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1116391010252 putative sugar binding sites [chemical binding]; other site 1116391010253 Q-X-W motif; other site 1116391010254 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1116391010255 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1116391010256 putative sugar binding sites [chemical binding]; other site 1116391010257 Q-X-W motif; other site 1116391010258 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1116391010259 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1116391010260 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1116391010261 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1116391010262 ligand binding site [chemical binding]; other site 1116391010263 metal binding site [ion binding]; metal-binding site 1116391010264 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391010265 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391010266 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391010267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010268 dimer interface [polypeptide binding]; other site 1116391010269 conserved gate region; other site 1116391010270 ABC-ATPase subunit interface; other site 1116391010271 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391010272 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010273 dimer interface [polypeptide binding]; other site 1116391010274 conserved gate region; other site 1116391010275 putative PBP binding loops; other site 1116391010276 ABC-ATPase subunit interface; other site 1116391010277 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391010278 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391010279 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391010280 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391010281 active site 1116391010282 phosphorylation site [posttranslational modification] 1116391010283 intermolecular recognition site; other site 1116391010284 dimerization interface [polypeptide binding]; other site 1116391010285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391010286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010287 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391010288 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391010289 dimerization interface [polypeptide binding]; other site 1116391010290 Histidine kinase; Region: His_kinase; pfam06580 1116391010291 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391010292 ATP binding site [chemical binding]; other site 1116391010293 Mg2+ binding site [ion binding]; other site 1116391010294 G-X-G motif; other site 1116391010295 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1116391010296 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 1116391010297 putative active site [active] 1116391010298 putative metal binding site [ion binding]; other site 1116391010299 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 1116391010300 Asp-box motif; other site 1116391010301 BNR repeat-like domain; Region: BNR_2; pfam13088 1116391010302 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391010303 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010304 dimer interface [polypeptide binding]; other site 1116391010305 conserved gate region; other site 1116391010306 putative PBP binding loops; other site 1116391010307 ABC-ATPase subunit interface; other site 1116391010308 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1116391010309 Yip1 domain; Region: Yip1; pfam04893 1116391010310 NHL repeat; Region: NHL; pfam01436 1116391010311 NHL repeat; Region: NHL; pfam01436 1116391010312 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1116391010313 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1116391010314 TPR motif; other site 1116391010315 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391010316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010317 dimer interface [polypeptide binding]; other site 1116391010318 conserved gate region; other site 1116391010319 ABC-ATPase subunit interface; other site 1116391010320 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391010321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010322 dimer interface [polypeptide binding]; other site 1116391010323 conserved gate region; other site 1116391010324 putative PBP binding loops; other site 1116391010325 ABC-ATPase subunit interface; other site 1116391010326 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1116391010327 putative metal binding site [ion binding]; other site 1116391010328 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1116391010329 putative metal binding site [ion binding]; other site 1116391010330 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391010331 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391010332 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391010333 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391010334 Cupin domain; Region: Cupin_2; pfam07883 1116391010335 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010336 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391010337 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010338 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391010339 Erythromycin esterase; Region: Erythro_esteras; cl17110 1116391010340 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1116391010341 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391010342 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391010343 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1116391010344 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1116391010345 trimer interface [polypeptide binding]; other site 1116391010346 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 1116391010347 trimer interface [polypeptide binding]; other site 1116391010348 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 1116391010349 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1116391010350 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391010351 DNA binding residues [nucleotide binding] 1116391010352 dimerization interface [polypeptide binding]; other site 1116391010353 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391010354 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1116391010355 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1116391010356 putative catalytic site [active] 1116391010357 putative metal binding site [ion binding]; other site 1116391010358 putative phosphate binding site [ion binding]; other site 1116391010359 MAC/Perforin domain; Region: MACPF; cl02616 1116391010360 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1116391010361 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 1116391010362 dimerization interface [polypeptide binding]; other site 1116391010363 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 1116391010364 mannose binding site [chemical binding]; other site 1116391010365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391010366 Coenzyme A binding pocket [chemical binding]; other site 1116391010367 beta-D-glucuronidase; Provisional; Region: PRK10150 1116391010368 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1116391010369 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391010370 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1116391010371 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391010372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010373 dimer interface [polypeptide binding]; other site 1116391010374 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1116391010375 ABC-ATPase subunit interface; other site 1116391010376 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391010377 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010378 dimer interface [polypeptide binding]; other site 1116391010379 conserved gate region; other site 1116391010380 putative PBP binding loops; other site 1116391010381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391010382 ABC-ATPase subunit interface; other site 1116391010383 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391010384 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391010385 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010386 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391010387 Condensation domain; Region: Condensation; pfam00668 1116391010388 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391010389 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391010390 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391010391 acyl-activating enzyme (AAE) consensus motif; other site 1116391010392 AMP binding site [chemical binding]; other site 1116391010393 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391010394 Condensation domain; Region: Condensation; pfam00668 1116391010395 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391010396 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1116391010397 Condensation domain; Region: Condensation; pfam00668 1116391010398 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391010399 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1116391010400 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1116391010401 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391010402 acyl-activating enzyme (AAE) consensus motif; other site 1116391010403 AMP binding site [chemical binding]; other site 1116391010404 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391010405 Condensation domain; Region: Condensation; pfam00668 1116391010406 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391010407 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391010408 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1116391010409 acyl-activating enzyme (AAE) consensus motif; other site 1116391010410 AMP binding site [chemical binding]; other site 1116391010411 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391010412 Condensation domain; Region: Condensation; pfam00668 1116391010413 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391010414 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391010415 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391010416 acyl-activating enzyme (AAE) consensus motif; other site 1116391010417 AMP binding site [chemical binding]; other site 1116391010418 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391010419 Condensation domain; Region: Condensation; pfam00668 1116391010420 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391010421 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391010422 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391010423 acyl-activating enzyme (AAE) consensus motif; other site 1116391010424 AMP binding site [chemical binding]; other site 1116391010425 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391010426 Condensation domain; Region: Condensation; pfam00668 1116391010427 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391010428 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391010429 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391010430 acyl-activating enzyme (AAE) consensus motif; other site 1116391010431 AMP binding site [chemical binding]; other site 1116391010432 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391010433 Condensation domain; Region: Condensation; pfam00668 1116391010434 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391010435 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391010436 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1116391010437 acyl-activating enzyme (AAE) consensus motif; other site 1116391010438 AMP binding site [chemical binding]; other site 1116391010439 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391010440 Condensation domain; Region: Condensation; pfam00668 1116391010441 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391010442 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391010443 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391010444 acyl-activating enzyme (AAE) consensus motif; other site 1116391010445 AMP binding site [chemical binding]; other site 1116391010446 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391010447 Condensation domain; Region: Condensation; pfam00668 1116391010448 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391010449 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391010450 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1116391010451 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1116391010452 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391010453 acyl-activating enzyme (AAE) consensus motif; other site 1116391010454 AMP binding site [chemical binding]; other site 1116391010455 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391010456 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1116391010457 active site 1116391010458 metal binding site [ion binding]; metal-binding site 1116391010459 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1116391010460 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1116391010461 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1116391010462 putative sugar binding sites [chemical binding]; other site 1116391010463 Q-X-W motif; other site 1116391010464 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1116391010465 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391010466 active site 1116391010467 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391010468 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010469 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1116391010470 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1116391010471 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391010472 MarR family; Region: MarR; pfam01047 1116391010473 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 1116391010474 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1116391010475 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391010476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010477 dimer interface [polypeptide binding]; other site 1116391010478 conserved gate region; other site 1116391010479 putative PBP binding loops; other site 1116391010480 ABC-ATPase subunit interface; other site 1116391010481 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391010482 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010483 dimer interface [polypeptide binding]; other site 1116391010484 conserved gate region; other site 1116391010485 ABC-ATPase subunit interface; other site 1116391010486 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391010487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010488 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391010489 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1116391010491 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 1116391010492 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1116391010493 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391010494 Coenzyme A binding pocket [chemical binding]; other site 1116391010495 DinB superfamily; Region: DinB_2; pfam12867 1116391010496 DinB family; Region: DinB; cl17821 1116391010497 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1116391010498 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391010499 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1116391010500 Coenzyme A binding pocket [chemical binding]; other site 1116391010501 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1116391010502 active site 1116391010503 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1116391010504 DinB family; Region: DinB; cl17821 1116391010505 DinB superfamily; Region: DinB_2; pfam12867 1116391010506 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1116391010507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391010508 Coenzyme A binding pocket [chemical binding]; other site 1116391010509 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1116391010510 ligand-binding site [chemical binding]; other site 1116391010511 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1116391010512 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391010513 FeS/SAM binding site; other site 1116391010514 coproporphyrinogen III oxidase; Validated; Region: PRK08208 1116391010515 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391010516 FeS/SAM binding site; other site 1116391010517 HemN C-terminal domain; Region: HemN_C; pfam06969 1116391010518 Sulfatase; Region: Sulfatase; cl17466 1116391010519 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 1116391010520 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1116391010521 Substrate binding site [chemical binding]; other site 1116391010522 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1116391010523 hydrophobic ligand binding site; other site 1116391010524 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1116391010525 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1116391010526 substrate binding pocket [chemical binding]; other site 1116391010527 catalytic triad [active] 1116391010528 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391010529 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391010530 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1116391010531 Walker A/P-loop; other site 1116391010532 ATP binding site [chemical binding]; other site 1116391010533 Q-loop/lid; other site 1116391010534 ABC transporter signature motif; other site 1116391010535 Walker B; other site 1116391010536 D-loop; other site 1116391010537 H-loop/switch region; other site 1116391010538 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391010539 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391010540 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391010541 Walker A/P-loop; other site 1116391010542 ATP binding site [chemical binding]; other site 1116391010543 Q-loop/lid; other site 1116391010544 ABC transporter signature motif; other site 1116391010545 Walker B; other site 1116391010546 D-loop; other site 1116391010547 H-loop/switch region; other site 1116391010548 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391010549 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391010550 dipeptidase PepV; Reviewed; Region: PRK07318 1116391010551 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1116391010552 active site 1116391010553 metal binding site [ion binding]; metal-binding site 1116391010554 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 1116391010555 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1116391010556 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1116391010557 SnoaL-like domain; Region: SnoaL_2; pfam12680 1116391010558 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1116391010559 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 1116391010560 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391010561 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391010562 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1116391010563 Predicted transcriptional regulator [Transcription]; Region: COG2378 1116391010564 HTH domain; Region: HTH_11; pfam08279 1116391010565 WYL domain; Region: WYL; pfam13280 1116391010566 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1116391010567 dimer interface [polypeptide binding]; other site 1116391010568 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391010569 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391010570 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391010571 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1116391010572 putative dimerization interface [polypeptide binding]; other site 1116391010573 OsmC-like protein; Region: OsmC; pfam02566 1116391010574 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1116391010575 substrate binding site [chemical binding]; other site 1116391010576 THF binding site; other site 1116391010577 zinc-binding site [ion binding]; other site 1116391010578 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1116391010579 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391010580 substrate binding pocket [chemical binding]; other site 1116391010581 membrane-bound complex binding site; other site 1116391010582 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1116391010583 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1116391010584 active site 1116391010585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391010586 active site 1116391010587 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391010588 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391010589 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391010590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391010591 active site 1116391010592 phosphorylation site [posttranslational modification] 1116391010593 intermolecular recognition site; other site 1116391010594 dimerization interface [polypeptide binding]; other site 1116391010595 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391010596 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010597 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010598 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391010599 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391010600 dimerization interface [polypeptide binding]; other site 1116391010601 Histidine kinase; Region: His_kinase; pfam06580 1116391010602 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391010603 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010604 dimer interface [polypeptide binding]; other site 1116391010605 conserved gate region; other site 1116391010606 putative PBP binding loops; other site 1116391010607 ABC-ATPase subunit interface; other site 1116391010608 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391010609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010610 dimer interface [polypeptide binding]; other site 1116391010611 conserved gate region; other site 1116391010612 ABC-ATPase subunit interface; other site 1116391010613 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391010614 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1116391010615 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1116391010616 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1116391010617 putative ligand binding site [chemical binding]; other site 1116391010618 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 1116391010619 Ca binding site [ion binding]; other site 1116391010620 carbohydrate binding site [chemical binding]; other site 1116391010621 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391010622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010623 dimer interface [polypeptide binding]; other site 1116391010624 conserved gate region; other site 1116391010625 ABC-ATPase subunit interface; other site 1116391010626 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391010627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010628 dimer interface [polypeptide binding]; other site 1116391010629 conserved gate region; other site 1116391010630 ABC-ATPase subunit interface; other site 1116391010631 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391010632 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391010633 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391010634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391010635 active site 1116391010636 phosphorylation site [posttranslational modification] 1116391010637 intermolecular recognition site; other site 1116391010638 dimerization interface [polypeptide binding]; other site 1116391010639 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1116391010640 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391010641 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391010642 HAMP domain; Region: HAMP; pfam00672 1116391010643 Histidine kinase; Region: His_kinase; pfam06580 1116391010644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391010645 ATP binding site [chemical binding]; other site 1116391010646 Mg2+ binding site [ion binding]; other site 1116391010647 G-X-G motif; other site 1116391010648 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391010649 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391010650 active site 1116391010651 phosphorylation site [posttranslational modification] 1116391010652 intermolecular recognition site; other site 1116391010653 dimerization interface [polypeptide binding]; other site 1116391010654 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391010655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010656 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010657 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391010658 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391010659 dimerization interface [polypeptide binding]; other site 1116391010660 Histidine kinase; Region: His_kinase; pfam06580 1116391010661 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391010662 ATP binding site [chemical binding]; other site 1116391010663 Mg2+ binding site [ion binding]; other site 1116391010664 G-X-G motif; other site 1116391010665 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391010666 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1116391010667 substrate binding site [chemical binding]; other site 1116391010668 active site 1116391010669 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1116391010670 metal binding site [ion binding]; metal-binding site 1116391010671 ligand binding site [chemical binding]; other site 1116391010672 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1116391010673 metal binding site [ion binding]; metal-binding site 1116391010674 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391010675 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391010676 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1116391010677 dimerization interface [polypeptide binding]; other site 1116391010678 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1116391010679 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1116391010680 active site 1116391010681 FMN binding site [chemical binding]; other site 1116391010682 substrate binding site [chemical binding]; other site 1116391010683 putative catalytic residue [active] 1116391010684 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1116391010685 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1116391010686 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1116391010687 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1116391010688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391010689 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391010690 Q-loop/lid; other site 1116391010691 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391010692 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391010693 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1116391010694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010695 dimer interface [polypeptide binding]; other site 1116391010696 conserved gate region; other site 1116391010697 putative PBP binding loops; other site 1116391010698 ABC-ATPase subunit interface; other site 1116391010699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010700 dimer interface [polypeptide binding]; other site 1116391010701 conserved gate region; other site 1116391010702 putative PBP binding loops; other site 1116391010703 ABC-ATPase subunit interface; other site 1116391010704 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1116391010705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391010706 Walker A/P-loop; other site 1116391010707 ATP binding site [chemical binding]; other site 1116391010708 Q-loop/lid; other site 1116391010709 ABC transporter signature motif; other site 1116391010710 Walker B; other site 1116391010711 D-loop; other site 1116391010712 H-loop/switch region; other site 1116391010713 TOBE domain; Region: TOBE_2; pfam08402 1116391010714 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1116391010715 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1116391010716 putative hydrolase; Provisional; Region: PRK02113 1116391010717 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1116391010718 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1116391010719 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1116391010720 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391010721 DNA-binding site [nucleotide binding]; DNA binding site 1116391010722 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1116391010723 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1116391010724 ligand binding site [chemical binding]; other site 1116391010725 dimerization interface [polypeptide binding]; other site 1116391010726 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391010727 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391010728 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1116391010729 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1116391010730 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391010731 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391010732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391010733 active site 1116391010734 phosphorylation site [posttranslational modification] 1116391010735 intermolecular recognition site; other site 1116391010736 dimerization interface [polypeptide binding]; other site 1116391010737 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391010738 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010740 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391010741 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391010742 dimerization interface [polypeptide binding]; other site 1116391010743 Histidine kinase; Region: His_kinase; pfam06580 1116391010744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391010745 ATP binding site [chemical binding]; other site 1116391010746 Mg2+ binding site [ion binding]; other site 1116391010747 G-X-G motif; other site 1116391010748 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391010749 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1116391010750 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1116391010751 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1116391010752 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391010753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010754 dimer interface [polypeptide binding]; other site 1116391010755 conserved gate region; other site 1116391010756 putative PBP binding loops; other site 1116391010757 ABC-ATPase subunit interface; other site 1116391010758 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1116391010759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010760 dimer interface [polypeptide binding]; other site 1116391010761 conserved gate region; other site 1116391010762 putative PBP binding loops; other site 1116391010763 ABC-ATPase subunit interface; other site 1116391010764 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391010765 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1116391010766 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1116391010767 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391010768 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391010769 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1116391010770 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391010771 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391010772 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391010773 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1116391010774 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391010775 putative active site [active] 1116391010776 putative metal binding site [ion binding]; other site 1116391010777 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1116391010778 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391010779 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010780 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391010781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391010782 putative substrate translocation pore; other site 1116391010783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391010784 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391010785 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391010786 short chain dehydrogenase; Provisional; Region: PRK06924 1116391010787 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391010788 NAD(P) binding site [chemical binding]; other site 1116391010789 active site 1116391010790 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1116391010791 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1116391010792 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 1116391010793 putative NAD(P) binding site [chemical binding]; other site 1116391010794 active site 1116391010795 putative substrate binding site [chemical binding]; other site 1116391010796 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1116391010797 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1116391010798 active site pocket [active] 1116391010799 oxyanion hole [active] 1116391010800 catalytic triad [active] 1116391010801 active site nucleophile [active] 1116391010802 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 1116391010803 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1116391010804 dimer interface [polypeptide binding]; other site 1116391010805 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391010806 ligand binding site [chemical binding]; other site 1116391010807 Cupin domain; Region: Cupin_2; pfam07883 1116391010808 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391010809 MarR family; Region: MarR; pfam01047 1116391010810 hypothetical protein; Provisional; Region: PRK08244 1116391010811 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1116391010812 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1116391010813 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1116391010814 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1116391010815 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1116391010816 inhibitor binding site; inhibition site 1116391010817 active site 1116391010818 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391010819 Cupin domain; Region: Cupin_2; cl17218 1116391010820 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391010821 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010822 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010823 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391010824 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 1116391010825 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391010826 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391010827 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1116391010828 putative dimer interface [polypeptide binding]; other site 1116391010829 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391010830 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1116391010831 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1116391010832 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1116391010833 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 1116391010834 Transposase; Region: DEDD_Tnp_IS110; pfam01548 1116391010835 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 1116391010836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391010837 putative substrate translocation pore; other site 1116391010838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391010839 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391010840 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391010841 dimerization interface [polypeptide binding]; other site 1116391010842 putative DNA binding site [nucleotide binding]; other site 1116391010843 putative Zn2+ binding site [ion binding]; other site 1116391010844 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1116391010845 short chain dehydrogenase; Provisional; Region: PRK08263 1116391010846 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1116391010847 NADP binding site [chemical binding]; other site 1116391010848 active site 1116391010849 steroid binding site; other site 1116391010850 Pectate lyase; Region: Pec_lyase_C; cl01593 1116391010851 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1116391010852 metal binding site [ion binding]; metal-binding site 1116391010853 ligand binding site [chemical binding]; other site 1116391010854 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391010855 glutamate dehydrogenase; Provisional; Region: PRK09414 1116391010856 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1116391010857 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1116391010858 NAD(P) binding site [chemical binding]; other site 1116391010859 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391010860 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391010861 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1116391010862 putative dimerization interface [polypeptide binding]; other site 1116391010863 Creatinine amidohydrolase; Region: Creatininase; cl00618 1116391010864 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391010865 active site 1116391010866 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391010867 catalytic tetrad [active] 1116391010868 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1116391010869 [2Fe-2S] cluster binding site [ion binding]; other site 1116391010870 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1116391010871 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 1116391010872 putative di-iron ligands [ion binding]; other site 1116391010873 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391010874 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1116391010875 AP (apurinic/apyrimidinic) site pocket; other site 1116391010876 DNA interaction; other site 1116391010877 Metal-binding active site; metal-binding site 1116391010878 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391010879 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391010880 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1116391010881 active site 1116391010882 catalytic residues [active] 1116391010883 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1116391010884 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1116391010885 inhibitor binding site; inhibition site 1116391010886 active site 1116391010887 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391010888 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391010889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010890 dimer interface [polypeptide binding]; other site 1116391010891 conserved gate region; other site 1116391010892 putative PBP binding loops; other site 1116391010893 ABC-ATPase subunit interface; other site 1116391010894 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391010895 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1116391010896 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1116391010897 Helix-turn-helix domain; Region: HTH_18; pfam12833 1116391010898 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391010899 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391010900 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1116391010901 active site 2 [active] 1116391010902 active site 1 [active] 1116391010903 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1116391010904 Amidohydrolase; Region: Amidohydro_2; pfam04909 1116391010905 active site 1116391010906 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1116391010907 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391010908 DNA-binding site [nucleotide binding]; DNA binding site 1116391010909 FCD domain; Region: FCD; pfam07729 1116391010910 Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; cl01770 1116391010911 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1116391010912 EamA-like transporter family; Region: EamA; pfam00892 1116391010913 S-layer homology domain; Region: SLH; pfam00395 1116391010914 S-layer homology domain; Region: SLH; pfam00395 1116391010915 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1116391010916 S-layer homology domain; Region: SLH; pfam00395 1116391010917 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1116391010918 Dystroglycan-type cadherin-like domains; Region: CADG; smart00736 1116391010919 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1116391010920 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391010921 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391010922 putative DNA binding site [nucleotide binding]; other site 1116391010923 putative Zn2+ binding site [ion binding]; other site 1116391010924 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1116391010925 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391010926 NAD(P) binding site [chemical binding]; other site 1116391010927 active site 1116391010928 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1116391010929 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391010930 salt bridge; other site 1116391010931 non-specific DNA binding site [nucleotide binding]; other site 1116391010932 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1116391010933 sequence-specific DNA binding site [nucleotide binding]; other site 1116391010934 PAS domain; Region: PAS; smart00091 1116391010935 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1116391010936 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1116391010937 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 1116391010938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391010939 motif II; other site 1116391010940 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1116391010941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010942 dimer interface [polypeptide binding]; other site 1116391010943 conserved gate region; other site 1116391010944 putative PBP binding loops; other site 1116391010945 ABC-ATPase subunit interface; other site 1116391010946 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391010947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391010948 dimer interface [polypeptide binding]; other site 1116391010949 conserved gate region; other site 1116391010950 putative PBP binding loops; other site 1116391010951 ABC-ATPase subunit interface; other site 1116391010952 maltodextrin glucosidase; Provisional; Region: PRK10785 1116391010953 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1116391010954 homodimer interface [polypeptide binding]; other site 1116391010955 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1116391010956 active site 1116391010957 homodimer interface [polypeptide binding]; other site 1116391010958 catalytic site [active] 1116391010959 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1116391010960 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1116391010961 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1116391010962 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391010963 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391010964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391010965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391010966 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1116391010967 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1116391010968 active site 1116391010969 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1116391010970 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1116391010971 dimer interface [polypeptide binding]; other site 1116391010972 active site 1116391010973 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391010974 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1116391010975 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1116391010976 NAD(P) binding site [chemical binding]; other site 1116391010977 homotetramer interface [polypeptide binding]; other site 1116391010978 homodimer interface [polypeptide binding]; other site 1116391010979 active site 1116391010980 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1116391010981 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1116391010982 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1116391010983 Methylamine utilisation protein MauE; Region: MauE; pfam07291 1116391010984 Condensation domain; Region: Condensation; pfam00668 1116391010985 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391010986 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391010987 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391010988 acyl-activating enzyme (AAE) consensus motif; other site 1116391010989 AMP binding site [chemical binding]; other site 1116391010990 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391010991 Condensation domain; Region: Condensation; pfam00668 1116391010992 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391010993 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391010994 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391010995 acyl-activating enzyme (AAE) consensus motif; other site 1116391010996 AMP binding site [chemical binding]; other site 1116391010997 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391010998 Condensation domain; Region: Condensation; pfam00668 1116391010999 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011000 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011001 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1116391011002 acyl-activating enzyme (AAE) consensus motif; other site 1116391011003 AMP binding site [chemical binding]; other site 1116391011004 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011005 Condensation domain; Region: Condensation; pfam00668 1116391011006 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1116391011007 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1116391011008 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1116391011009 active site 1116391011010 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1116391011011 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1116391011012 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 1116391011013 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1116391011014 putative NADP binding site [chemical binding]; other site 1116391011015 active site 1116391011016 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1116391011017 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1116391011018 peptide synthase; Provisional; Region: PRK12467 1116391011019 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391011020 acyl-activating enzyme (AAE) consensus motif; other site 1116391011021 AMP binding site [chemical binding]; other site 1116391011022 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011023 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011024 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391011025 acyl-activating enzyme (AAE) consensus motif; other site 1116391011026 AMP binding site [chemical binding]; other site 1116391011027 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011028 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1116391011029 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1116391011030 acyl-activating enzyme (AAE) consensus motif; other site 1116391011031 AMP binding site [chemical binding]; other site 1116391011032 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011033 Condensation domain; Region: Condensation; pfam00668 1116391011034 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1116391011035 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1116391011036 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1116391011037 acyl-activating enzyme (AAE) consensus motif; other site 1116391011038 AMP binding site [chemical binding]; other site 1116391011039 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011040 Condensation domain; Region: Condensation; pfam00668 1116391011041 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011042 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391011043 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1116391011044 acyl-activating enzyme (AAE) consensus motif; other site 1116391011045 AMP binding site [chemical binding]; other site 1116391011046 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011047 Condensation domain; Region: Condensation; pfam00668 1116391011048 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011049 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011050 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391011051 acyl-activating enzyme (AAE) consensus motif; other site 1116391011052 AMP binding site [chemical binding]; other site 1116391011053 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011054 Condensation domain; Region: Condensation; pfam00668 1116391011055 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011056 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011057 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1116391011058 acyl-activating enzyme (AAE) consensus motif; other site 1116391011059 AMP binding site [chemical binding]; other site 1116391011060 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011061 Condensation domain; Region: Condensation; pfam00668 1116391011062 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011063 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1116391011064 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1116391011065 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 1116391011066 acyl-activating enzyme (AAE) consensus motif; other site 1116391011067 putative AMP binding site [chemical binding]; other site 1116391011068 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011069 Condensation domain; Region: Condensation; pfam00668 1116391011070 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011071 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011072 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1116391011073 acyl-activating enzyme (AAE) consensus motif; other site 1116391011074 AMP binding site [chemical binding]; other site 1116391011075 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011076 Condensation domain; Region: Condensation; pfam00668 1116391011077 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1116391011078 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1116391011079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391011080 H+ Antiporter protein; Region: 2A0121; TIGR00900 1116391011081 putative substrate translocation pore; other site 1116391011082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391011083 DNA binding residues [nucleotide binding] 1116391011084 Condensation domain; Region: Condensation; pfam00668 1116391011085 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011086 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1116391011087 acyl-activating enzyme (AAE) consensus motif; other site 1116391011088 AMP binding site [chemical binding]; other site 1116391011089 active site 1116391011090 CoA binding site [chemical binding]; other site 1116391011091 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011092 Condensation domain; Region: Condensation; pfam00668 1116391011093 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011094 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1116391011095 acyl-activating enzyme (AAE) consensus motif; other site 1116391011096 AMP binding site [chemical binding]; other site 1116391011097 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011098 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1116391011099 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1116391011100 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1116391011101 acyl-activating enzyme (AAE) consensus motif; other site 1116391011102 AMP binding site [chemical binding]; other site 1116391011103 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011104 Condensation domain; Region: Condensation; pfam00668 1116391011105 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011106 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011107 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1116391011108 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1116391011109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391011110 S-adenosylmethionine binding site [chemical binding]; other site 1116391011111 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391011112 acyl-activating enzyme (AAE) consensus motif; other site 1116391011113 AMP binding site [chemical binding]; other site 1116391011114 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011115 Condensation domain; Region: Condensation; pfam00668 1116391011116 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1116391011117 Condensation domain; Region: Condensation; pfam00668 1116391011118 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011119 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1116391011120 acyl-activating enzyme (AAE) consensus motif; other site 1116391011121 AMP binding site [chemical binding]; other site 1116391011122 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011123 Thioesterase domain; Region: Thioesterase; pfam00975 1116391011124 Condensation domain; Region: Condensation; pfam00668 1116391011125 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1116391011126 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1116391011127 acyl-activating enzyme (AAE) consensus motif; other site 1116391011128 AMP binding site [chemical binding]; other site 1116391011129 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011130 Condensation domain; Region: Condensation; pfam00668 1116391011131 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011132 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011133 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1116391011134 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1116391011135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391011136 S-adenosylmethionine binding site [chemical binding]; other site 1116391011137 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1116391011138 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1116391011139 acyl-activating enzyme (AAE) consensus motif; other site 1116391011140 AMP binding site [chemical binding]; other site 1116391011141 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011142 Condensation domain; Region: Condensation; pfam00668 1116391011143 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011144 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011145 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1116391011146 acyl-activating enzyme (AAE) consensus motif; other site 1116391011147 AMP binding site [chemical binding]; other site 1116391011148 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011149 Condensation domain; Region: Condensation; pfam00668 1116391011150 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011151 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011152 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1116391011153 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1116391011154 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1116391011155 trimer interface [polypeptide binding]; other site 1116391011156 active site 1116391011157 substrate binding site [chemical binding]; other site 1116391011158 CoA binding site [chemical binding]; other site 1116391011159 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 1116391011160 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1116391011161 TrkA-N domain; Region: TrkA_N; pfam02254 1116391011162 TrkA-C domain; Region: TrkA_C; pfam02080 1116391011163 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391011164 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391011165 Transposase; Region: HTH_Tnp_1; cl17663 1116391011166 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391011167 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391011168 HTH-like domain; Region: HTH_21; pfam13276 1116391011169 Integrase core domain; Region: rve; pfam00665 1116391011170 Integrase core domain; Region: rve_2; pfam13333 1116391011171 OsmC-like protein; Region: OsmC; pfam02566 1116391011172 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391011173 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1116391011174 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391011175 Ferredoxin [Energy production and conversion]; Region: COG1146 1116391011176 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1116391011177 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1116391011178 Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138 1116391011179 putative FMN binding site [chemical binding]; other site 1116391011180 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391011181 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1116391011182 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1116391011183 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1116391011184 active site 1116391011185 non-prolyl cis peptide bond; other site 1116391011186 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1116391011187 dimer interface [polypeptide binding]; other site 1116391011188 FMN binding site [chemical binding]; other site 1116391011189 NADPH bind site [chemical binding]; other site 1116391011190 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1116391011191 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1116391011192 active site 1116391011193 non-prolyl cis peptide bond; other site 1116391011194 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391011195 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391011196 active site 1116391011197 catalytic tetrad [active] 1116391011198 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391011199 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1116391011200 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1116391011201 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1116391011202 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1116391011203 active site 1116391011204 non-prolyl cis peptide bond; other site 1116391011205 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1116391011206 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1116391011207 active site 1116391011208 non-prolyl cis peptide bond; other site 1116391011209 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391011210 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391011211 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1116391011212 Walker A/P-loop; other site 1116391011213 ATP binding site [chemical binding]; other site 1116391011214 Q-loop/lid; other site 1116391011215 ABC transporter signature motif; other site 1116391011216 Walker B; other site 1116391011217 D-loop; other site 1116391011218 H-loop/switch region; other site 1116391011219 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391011220 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391011221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391011222 Walker A/P-loop; other site 1116391011223 ATP binding site [chemical binding]; other site 1116391011224 Q-loop/lid; other site 1116391011225 ABC transporter signature motif; other site 1116391011226 Walker B; other site 1116391011227 D-loop; other site 1116391011228 H-loop/switch region; other site 1116391011229 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1116391011230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011231 dimer interface [polypeptide binding]; other site 1116391011232 conserved gate region; other site 1116391011233 putative PBP binding loops; other site 1116391011234 ABC-ATPase subunit interface; other site 1116391011235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011236 ABC-ATPase subunit interface; other site 1116391011237 putative PBP binding loops; other site 1116391011238 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 1116391011239 NHL repeat; Region: NHL; pfam01436 1116391011240 NHL repeat; Region: NHL; pfam01436 1116391011241 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1116391011242 Yip1 domain; Region: Yip1; cl17815 1116391011243 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391011244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011245 dimer interface [polypeptide binding]; other site 1116391011246 conserved gate region; other site 1116391011247 putative PBP binding loops; other site 1116391011248 ABC-ATPase subunit interface; other site 1116391011249 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391011250 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011251 dimer interface [polypeptide binding]; other site 1116391011252 conserved gate region; other site 1116391011253 putative PBP binding loops; other site 1116391011254 ABC-ATPase subunit interface; other site 1116391011255 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1116391011256 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1116391011257 Walker A/P-loop; other site 1116391011258 ATP binding site [chemical binding]; other site 1116391011259 Q-loop/lid; other site 1116391011260 ABC transporter signature motif; other site 1116391011261 Walker B; other site 1116391011262 D-loop; other site 1116391011263 H-loop/switch region; other site 1116391011264 TOBE domain; Region: TOBE_2; pfam08402 1116391011265 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1116391011266 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1116391011267 Cysteine-rich domain; Region: CCG; pfam02754 1116391011268 Cysteine-rich domain; Region: CCG; pfam02754 1116391011269 FAD binding domain; Region: FAD_binding_4; pfam01565 1116391011270 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 1116391011271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391011272 salt bridge; other site 1116391011273 non-specific DNA binding site [nucleotide binding]; other site 1116391011274 sequence-specific DNA binding site [nucleotide binding]; other site 1116391011275 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 1116391011276 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1116391011277 putative catalytic site [active] 1116391011278 putative metal binding site [ion binding]; other site 1116391011279 putative phosphate binding site [ion binding]; other site 1116391011280 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 1116391011281 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 1116391011282 putative NAD(P) binding site [chemical binding]; other site 1116391011283 dimer interface [polypeptide binding]; other site 1116391011284 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 1116391011285 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391011286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391011287 putative substrate translocation pore; other site 1116391011288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391011289 Helix-turn-helix domain; Region: HTH_31; pfam13560 1116391011290 salt bridge; other site 1116391011291 non-specific DNA binding site [nucleotide binding]; other site 1116391011292 sequence-specific DNA binding site [nucleotide binding]; other site 1116391011293 DinB family; Region: DinB; cl17821 1116391011294 DinB superfamily; Region: DinB_2; pfam12867 1116391011295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391011296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391011297 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1116391011298 dimerization interface [polypeptide binding]; other site 1116391011299 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1116391011300 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391011301 MarR family; Region: MarR_2; pfam12802 1116391011302 RibD C-terminal domain; Region: RibD_C; cl17279 1116391011303 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391011304 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1116391011305 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391011306 putative DNA binding site [nucleotide binding]; other site 1116391011307 putative Zn2+ binding site [ion binding]; other site 1116391011308 AsnC family; Region: AsnC_trans_reg; pfam01037 1116391011309 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1116391011310 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1116391011311 putative NAD(P) binding site [chemical binding]; other site 1116391011312 putative substrate binding site [chemical binding]; other site 1116391011313 catalytic Zn binding site [ion binding]; other site 1116391011314 structural Zn binding site [ion binding]; other site 1116391011315 dimer interface [polypeptide binding]; other site 1116391011316 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1116391011317 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1116391011318 dimer interface [polypeptide binding]; other site 1116391011319 PYR/PP interface [polypeptide binding]; other site 1116391011320 TPP binding site [chemical binding]; other site 1116391011321 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1116391011322 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1116391011323 TPP-binding site [chemical binding]; other site 1116391011324 dimer interface [polypeptide binding]; other site 1116391011325 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1116391011326 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1116391011327 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391011328 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391011329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391011330 HAMP domain; Region: HAMP; pfam00672 1116391011331 dimerization interface [polypeptide binding]; other site 1116391011332 Histidine kinase; Region: His_kinase; pfam06580 1116391011333 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391011334 ATP binding site [chemical binding]; other site 1116391011335 Mg2+ binding site [ion binding]; other site 1116391011336 G-X-G motif; other site 1116391011337 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391011338 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391011339 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011340 dimer interface [polypeptide binding]; other site 1116391011341 conserved gate region; other site 1116391011342 putative PBP binding loops; other site 1116391011343 ABC-ATPase subunit interface; other site 1116391011344 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391011345 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011346 dimer interface [polypeptide binding]; other site 1116391011347 conserved gate region; other site 1116391011348 ABC-ATPase subunit interface; other site 1116391011349 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1116391011350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391011351 active site 1116391011352 phosphorylation site [posttranslational modification] 1116391011353 intermolecular recognition site; other site 1116391011354 dimerization interface [polypeptide binding]; other site 1116391011355 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011356 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1116391011357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391011358 DNA-binding site [nucleotide binding]; DNA binding site 1116391011359 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391011360 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391011361 homodimer interface [polypeptide binding]; other site 1116391011362 catalytic residue [active] 1116391011363 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1116391011364 dimer interface [polypeptide binding]; other site 1116391011365 FMN binding site [chemical binding]; other site 1116391011366 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1116391011367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391011368 sequence-specific DNA binding site [nucleotide binding]; other site 1116391011369 salt bridge; other site 1116391011370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391011371 S-adenosylmethionine binding site [chemical binding]; other site 1116391011372 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1116391011373 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1116391011374 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391011375 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391011376 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1116391011377 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1116391011378 HlyD family secretion protein; Region: HlyD_3; pfam13437 1116391011379 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391011380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1116391011381 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391011382 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391011383 metal binding site [ion binding]; metal-binding site 1116391011384 active site 1116391011385 I-site; other site 1116391011386 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1116391011387 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391011388 dimerization interface [polypeptide binding]; other site 1116391011389 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391011390 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391011391 dimer interface [polypeptide binding]; other site 1116391011392 putative CheW interface [polypeptide binding]; other site 1116391011393 Cache domain; Region: Cache_1; pfam02743 1116391011394 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1116391011395 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391011396 dimerization interface [polypeptide binding]; other site 1116391011397 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391011398 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391011399 metal binding site [ion binding]; metal-binding site 1116391011400 active site 1116391011401 I-site; other site 1116391011402 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1116391011403 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011404 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391011405 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011406 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1116391011407 Condensation domain; Region: Condensation; pfam00668 1116391011408 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011409 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011410 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391011411 acyl-activating enzyme (AAE) consensus motif; other site 1116391011412 AMP binding site [chemical binding]; other site 1116391011413 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011414 Condensation domain; Region: Condensation; pfam00668 1116391011415 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011416 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1116391011417 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1116391011418 active site 1116391011419 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011420 Condensation domain; Region: Condensation; pfam00668 1116391011421 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391011422 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1116391011423 acyl-activating enzyme (AAE) consensus motif; other site 1116391011424 AMP binding site [chemical binding]; other site 1116391011425 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011426 Condensation domain; Region: Condensation; pfam00668 1116391011427 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011428 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011429 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391011430 acyl-activating enzyme (AAE) consensus motif; other site 1116391011431 AMP binding site [chemical binding]; other site 1116391011432 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011433 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1116391011434 conserved cys residue [active] 1116391011435 Putative amidotransferase; Region: DUF4066; pfam13278 1116391011436 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1116391011437 Predicted transcriptional regulators [Transcription]; Region: COG1695 1116391011438 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1116391011439 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391011440 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1116391011441 acyl-activating enzyme (AAE) consensus motif; other site 1116391011442 AMP binding site [chemical binding]; other site 1116391011443 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011444 Condensation domain; Region: Condensation; pfam00668 1116391011445 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1116391011446 Condensation domain; Region: Condensation; pfam00668 1116391011447 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011448 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1116391011449 acyl-activating enzyme (AAE) consensus motif; other site 1116391011450 AMP binding site [chemical binding]; other site 1116391011451 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011452 Condensation domain; Region: Condensation; pfam00668 1116391011453 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011454 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011455 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1116391011456 acyl-activating enzyme (AAE) consensus motif; other site 1116391011457 AMP binding site [chemical binding]; other site 1116391011458 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011459 Condensation domain; Region: Condensation; pfam00668 1116391011460 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011461 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011462 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391011463 acyl-activating enzyme (AAE) consensus motif; other site 1116391011464 AMP binding site [chemical binding]; other site 1116391011465 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011466 Condensation domain; Region: Condensation; pfam00668 1116391011467 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011468 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011469 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391011470 acyl-activating enzyme (AAE) consensus motif; other site 1116391011471 AMP binding site [chemical binding]; other site 1116391011472 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011473 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1116391011474 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011475 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391011476 acyl-activating enzyme (AAE) consensus motif; other site 1116391011477 AMP binding site [chemical binding]; other site 1116391011478 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011479 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1116391011480 Condensation domain; Region: Condensation; pfam00668 1116391011481 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011482 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391011483 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391011484 acyl-activating enzyme (AAE) consensus motif; other site 1116391011485 AMP binding site [chemical binding]; other site 1116391011486 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391011487 Condensation domain; Region: Condensation; pfam00668 1116391011488 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011489 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1116391011490 Condensation domain; Region: Condensation; pfam00668 1116391011491 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391011492 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1116391011493 Lipase (class 2); Region: Lipase_2; pfam01674 1116391011494 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391011495 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391011496 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1116391011497 NAD(P) binding site [chemical binding]; other site 1116391011498 active site 1116391011499 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1116391011500 active site 1116391011501 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1116391011502 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1116391011503 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 1116391011504 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1116391011505 Walker A/P-loop; other site 1116391011506 ATP binding site [chemical binding]; other site 1116391011507 Q-loop/lid; other site 1116391011508 ABC transporter signature motif; other site 1116391011509 Walker B; other site 1116391011510 D-loop; other site 1116391011511 H-loop/switch region; other site 1116391011512 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1116391011513 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391011514 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1116391011515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011516 dimer interface [polypeptide binding]; other site 1116391011517 conserved gate region; other site 1116391011518 ABC-ATPase subunit interface; other site 1116391011519 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1116391011520 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391011521 substrate binding pocket [chemical binding]; other site 1116391011522 membrane-bound complex binding site; other site 1116391011523 hinge residues; other site 1116391011524 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391011525 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1116391011526 DNA-binding site [nucleotide binding]; DNA binding site 1116391011527 FCD domain; Region: FCD; pfam07729 1116391011528 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1116391011529 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1116391011530 Predicted permeases [General function prediction only]; Region: RarD; COG2962 1116391011531 EamA-like transporter family; Region: EamA; pfam00892 1116391011532 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391011533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011534 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391011535 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391011536 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391011537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011538 dimer interface [polypeptide binding]; other site 1116391011539 conserved gate region; other site 1116391011540 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391011541 ABC-ATPase subunit interface; other site 1116391011542 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391011543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011544 ABC-ATPase subunit interface; other site 1116391011545 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391011546 Interdomain contacts; other site 1116391011547 Cytokine receptor motif; other site 1116391011548 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391011549 Interdomain contacts; other site 1116391011550 Cytokine receptor motif; other site 1116391011551 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391011552 Interdomain contacts; other site 1116391011553 Cytokine receptor motif; other site 1116391011554 putative pectinesterase; Region: PLN02432; cl01911 1116391011555 Pectinesterase; Region: Pectinesterase; pfam01095 1116391011556 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1116391011557 active site 1116391011558 catalytic triad [active] 1116391011559 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391011560 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391011561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011563 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1116391011564 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1116391011565 putative NAD(P) binding site [chemical binding]; other site 1116391011566 catalytic Zn binding site [ion binding]; other site 1116391011567 structural Zn binding site [ion binding]; other site 1116391011568 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391011569 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391011570 active site 1116391011571 catalytic tetrad [active] 1116391011572 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391011573 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391011574 DNA binding site [nucleotide binding] 1116391011575 domain linker motif; other site 1116391011576 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1116391011577 dimerization interface [polypeptide binding]; other site 1116391011578 ligand binding site [chemical binding]; other site 1116391011579 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1116391011580 classical (c) SDRs; Region: SDR_c; cd05233 1116391011581 NAD(P) binding site [chemical binding]; other site 1116391011582 active site 1116391011583 Cytochrome P450; Region: p450; cl12078 1116391011584 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1116391011585 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391011586 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391011587 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 1116391011588 Major royal jelly protein; Region: MRJP; pfam03022 1116391011589 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1116391011590 dimer interface [polypeptide binding]; other site 1116391011591 FMN binding site [chemical binding]; other site 1116391011592 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1116391011593 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1116391011594 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1116391011595 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1116391011596 Cellulose binding domain; Region: CBM_3; pfam00942 1116391011597 endoglucanase; Region: PLN02308 1116391011598 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759 1116391011599 Cellulose binding domain; Region: CBM_3; pfam00942 1116391011600 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1116391011601 putative metal binding site [ion binding]; other site 1116391011602 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1116391011603 Cellulose binding domain; Region: CBM_3; pfam00942 1116391011604 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1116391011605 substrate binding site [chemical binding]; other site 1116391011606 active site 1116391011607 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1116391011608 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1116391011609 putative sugar binding sites [chemical binding]; other site 1116391011610 Q-X-W motif; other site 1116391011611 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391011612 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391011613 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391011614 dimerization interface [polypeptide binding]; other site 1116391011615 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1116391011616 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1116391011617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391011618 putative substrate translocation pore; other site 1116391011619 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 1116391011620 active site 1116391011621 catalytic triad [active] 1116391011622 oxyanion hole [active] 1116391011623 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1116391011624 Putative esterase; Region: Esterase; pfam00756 1116391011625 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1116391011626 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391011627 ABC-ATPase subunit interface; other site 1116391011628 dimer interface [polypeptide binding]; other site 1116391011629 putative PBP binding regions; other site 1116391011630 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1116391011631 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391011632 ABC-ATPase subunit interface; other site 1116391011633 dimer interface [polypeptide binding]; other site 1116391011634 putative PBP binding regions; other site 1116391011635 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1116391011636 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1116391011637 intersubunit interface [polypeptide binding]; other site 1116391011638 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391011639 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011640 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1116391011641 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1116391011642 intersubunit interface [polypeptide binding]; other site 1116391011643 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1116391011644 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1116391011645 NADP binding site [chemical binding]; other site 1116391011646 homodimer interface [polypeptide binding]; other site 1116391011647 active site 1116391011648 substrate binding site [chemical binding]; other site 1116391011649 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1116391011650 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011651 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391011652 Amb_all domain; Region: Amb_all; smart00656 1116391011653 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1116391011654 active site 1116391011655 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1116391011656 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1116391011657 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1116391011658 phosphate binding site [ion binding]; other site 1116391011659 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391011660 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391011661 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1116391011662 Walker A/P-loop; other site 1116391011663 ATP binding site [chemical binding]; other site 1116391011664 Q-loop/lid; other site 1116391011665 ABC transporter signature motif; other site 1116391011666 Walker B; other site 1116391011667 D-loop; other site 1116391011668 H-loop/switch region; other site 1116391011669 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391011670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391011671 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1116391011672 putative dimerization interface [polypeptide binding]; other site 1116391011673 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1116391011674 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1116391011675 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1116391011676 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1116391011677 active site 1116391011678 non-prolyl cis peptide bond; other site 1116391011679 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391011680 substrate binding pocket [chemical binding]; other site 1116391011681 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1116391011682 membrane-bound complex binding site; other site 1116391011683 hinge residues; other site 1116391011684 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1116391011685 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1116391011686 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391011687 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391011688 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1116391011689 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011690 dimer interface [polypeptide binding]; other site 1116391011691 conserved gate region; other site 1116391011692 putative PBP binding loops; other site 1116391011693 ABC-ATPase subunit interface; other site 1116391011694 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391011695 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391011696 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391011697 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011698 dimer interface [polypeptide binding]; other site 1116391011699 conserved gate region; other site 1116391011700 ABC-ATPase subunit interface; other site 1116391011701 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391011702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011703 dimer interface [polypeptide binding]; other site 1116391011704 conserved gate region; other site 1116391011705 ABC-ATPase subunit interface; other site 1116391011706 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391011707 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391011708 active site 1116391011709 phosphorylation site [posttranslational modification] 1116391011710 intermolecular recognition site; other site 1116391011711 dimerization interface [polypeptide binding]; other site 1116391011712 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011713 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391011714 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011715 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391011716 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391011717 dimerization interface [polypeptide binding]; other site 1116391011718 Histidine kinase; Region: His_kinase; pfam06580 1116391011719 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391011720 ATP binding site [chemical binding]; other site 1116391011721 Mg2+ binding site [ion binding]; other site 1116391011722 G-X-G motif; other site 1116391011723 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 1116391011724 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1116391011725 Melibiase; Region: Melibiase; pfam02065 1116391011726 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391011727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011728 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391011729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011730 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1116391011731 putative metal binding site [ion binding]; other site 1116391011732 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1116391011733 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1116391011734 hypothetical protein; Validated; Region: PRK00029 1116391011735 Pectate lyase; Region: Pec_lyase_C; cl01593 1116391011736 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391011737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391011738 putative substrate translocation pore; other site 1116391011739 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1116391011740 FAD binding domain; Region: FAD_binding_4; pfam01565 1116391011741 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391011742 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 1116391011743 putative hydrophobic ligand binding site [chemical binding]; other site 1116391011744 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1116391011745 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1116391011746 Predicted transcriptional regulator [Transcription]; Region: COG1959 1116391011747 Transcriptional regulator; Region: Rrf2; pfam02082 1116391011748 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391011749 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391011750 dimerization interface [polypeptide binding]; other site 1116391011751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391011752 dimer interface [polypeptide binding]; other site 1116391011753 phosphorylation site [posttranslational modification] 1116391011754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391011755 ATP binding site [chemical binding]; other site 1116391011756 Mg2+ binding site [ion binding]; other site 1116391011757 G-X-G motif; other site 1116391011758 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391011759 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391011760 active site 1116391011761 phosphorylation site [posttranslational modification] 1116391011762 intermolecular recognition site; other site 1116391011763 dimerization interface [polypeptide binding]; other site 1116391011764 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391011765 FOG: CBS domain [General function prediction only]; Region: COG0517 1116391011766 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 1116391011767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391011768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391011769 active site 1116391011770 phosphorylation site [posttranslational modification] 1116391011771 intermolecular recognition site; other site 1116391011772 dimerization interface [polypeptide binding]; other site 1116391011773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391011774 DNA binding site [nucleotide binding] 1116391011775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391011776 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391011777 dimerization interface [polypeptide binding]; other site 1116391011778 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391011779 dimer interface [polypeptide binding]; other site 1116391011780 phosphorylation site [posttranslational modification] 1116391011781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391011782 ATP binding site [chemical binding]; other site 1116391011783 Mg2+ binding site [ion binding]; other site 1116391011784 G-X-G motif; other site 1116391011785 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391011786 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1116391011787 Walker A/P-loop; other site 1116391011788 ATP binding site [chemical binding]; other site 1116391011789 Q-loop/lid; other site 1116391011790 ABC transporter signature motif; other site 1116391011791 Walker B; other site 1116391011792 D-loop; other site 1116391011793 H-loop/switch region; other site 1116391011794 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1116391011795 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1116391011796 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1116391011797 trimer interface [polypeptide binding]; other site 1116391011798 substrate binding site [chemical binding]; other site 1116391011799 Mn binding site [ion binding]; other site 1116391011800 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1116391011801 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1116391011802 inhibitor site; inhibition site 1116391011803 active site 1116391011804 dimer interface [polypeptide binding]; other site 1116391011805 catalytic residue [active] 1116391011806 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391011807 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391011808 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391011809 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391011810 Interdomain contacts; other site 1116391011811 Cytokine receptor motif; other site 1116391011812 putative pectinesterase; Region: PLN02432; cl01911 1116391011813 Pectinesterase; Region: Pectinesterase; pfam01095 1116391011814 Pectate lyase; Region: Pec_lyase_C; cl01593 1116391011815 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 1116391011816 Abhydrolase family; Region: Abhydrolase_7; pfam12715 1116391011817 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391011818 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391011819 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391011820 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1116391011821 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1116391011822 Walker A/P-loop; other site 1116391011823 ATP binding site [chemical binding]; other site 1116391011824 Q-loop/lid; other site 1116391011825 ABC transporter signature motif; other site 1116391011826 Walker B; other site 1116391011827 D-loop; other site 1116391011828 H-loop/switch region; other site 1116391011829 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1116391011830 FtsX-like permease family; Region: FtsX; pfam02687 1116391011831 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1116391011832 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1116391011833 HlyD family secretion protein; Region: HlyD_3; pfam13437 1116391011834 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1116391011835 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1116391011836 Walker A/P-loop; other site 1116391011837 ATP binding site [chemical binding]; other site 1116391011838 Q-loop/lid; other site 1116391011839 ABC transporter signature motif; other site 1116391011840 Walker B; other site 1116391011841 D-loop; other site 1116391011842 H-loop/switch region; other site 1116391011843 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 1116391011844 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1116391011845 DNA binding residues [nucleotide binding] 1116391011846 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1116391011847 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1116391011848 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1116391011849 S-layer homology domain; Region: SLH; pfam00395 1116391011850 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391011851 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391011852 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391011853 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391011854 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391011855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011856 dimer interface [polypeptide binding]; other site 1116391011857 conserved gate region; other site 1116391011858 putative PBP binding loops; other site 1116391011859 ABC-ATPase subunit interface; other site 1116391011860 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391011861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011862 ABC-ATPase subunit interface; other site 1116391011863 NHL repeat; Region: NHL; pfam01436 1116391011864 Yip1 domain; Region: Yip1; pfam04893 1116391011865 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1116391011866 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1116391011867 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1116391011868 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1116391011869 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1116391011870 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391011871 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1116391011872 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391011873 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391011874 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391011875 Integrase core domain; Region: rve_3; pfam13683 1116391011876 Integrase core domain; Region: rve; pfam00665 1116391011877 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391011878 Transposase; Region: HTH_Tnp_1; cl17663 1116391011879 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1116391011880 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1116391011881 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391011882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391011883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011884 dimer interface [polypeptide binding]; other site 1116391011885 conserved gate region; other site 1116391011886 ABC-ATPase subunit interface; other site 1116391011887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011888 dimer interface [polypeptide binding]; other site 1116391011889 conserved gate region; other site 1116391011890 putative PBP binding loops; other site 1116391011891 ABC-ATPase subunit interface; other site 1116391011892 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1116391011893 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1116391011894 putative metal binding site [ion binding]; other site 1116391011895 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391011896 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391011897 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1116391011898 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1116391011899 Walker A/P-loop; other site 1116391011900 ATP binding site [chemical binding]; other site 1116391011901 Q-loop/lid; other site 1116391011902 ABC transporter signature motif; other site 1116391011903 Walker B; other site 1116391011904 D-loop; other site 1116391011905 H-loop/switch region; other site 1116391011906 Abhydrolase family; Region: Abhydrolase_7; pfam12715 1116391011907 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391011908 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391011909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011910 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011911 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1116391011912 BNR repeat-like domain; Region: BNR_2; pfam13088 1116391011913 Trehalase; Region: Trehalase; cl17346 1116391011914 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 1116391011915 BNR repeat-like domain; Region: BNR_2; pfam13088 1116391011916 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 1116391011917 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1116391011918 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1116391011919 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1116391011920 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 1116391011921 active site 1116391011922 catalytic triad [active] 1116391011923 oxyanion hole [active] 1116391011924 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1116391011925 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1116391011926 inhibitor site; inhibition site 1116391011927 active site 1116391011928 dimer interface [polypeptide binding]; other site 1116391011929 catalytic residue [active] 1116391011930 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 1116391011931 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1116391011932 putative active site [active] 1116391011933 metal binding site [ion binding]; metal-binding site 1116391011934 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1116391011935 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1116391011936 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1116391011937 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1116391011938 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1116391011939 HTH-like domain; Region: HTH_21; pfam13276 1116391011940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391011941 Integrase core domain; Region: rve; pfam00665 1116391011942 Integrase core domain; Region: rve_3; pfam13683 1116391011943 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391011944 Transposase; Region: HTH_Tnp_1; cl17663 1116391011945 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391011946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011947 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 1116391011948 ABC-ATPase subunit interface; other site 1116391011949 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391011950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391011951 dimer interface [polypeptide binding]; other site 1116391011952 conserved gate region; other site 1116391011953 ABC-ATPase subunit interface; other site 1116391011954 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391011955 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391011956 dimerization interface [polypeptide binding]; other site 1116391011957 Histidine kinase; Region: His_kinase; pfam06580 1116391011958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391011959 ATP binding site [chemical binding]; other site 1116391011960 Mg2+ binding site [ion binding]; other site 1116391011961 G-X-G motif; other site 1116391011962 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391011963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391011964 active site 1116391011965 phosphorylation site [posttranslational modification] 1116391011966 intermolecular recognition site; other site 1116391011967 dimerization interface [polypeptide binding]; other site 1116391011968 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391011969 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391011970 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391011971 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1116391011972 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1116391011973 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391011974 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391011975 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391011976 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391011977 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391011978 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391011979 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1116391011980 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1116391011981 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391011982 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1116391011983 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1116391011984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1116391011985 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 1116391011986 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 1116391011987 dimer interface [polypeptide binding]; other site 1116391011988 active site 1116391011989 catalytic residue [active] 1116391011990 metal binding site [ion binding]; metal-binding site 1116391011991 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1116391011992 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1116391011993 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1116391011994 active site 1116391011995 intersubunit interface [polypeptide binding]; other site 1116391011996 catalytic residue [active] 1116391011997 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1116391011998 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391011999 NAD(P) binding site [chemical binding]; other site 1116391012000 active site 1116391012001 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1116391012002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1116391012003 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391012004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012005 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1116391012006 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1116391012007 N- and C-terminal domain interface [polypeptide binding]; other site 1116391012008 active site 1116391012009 MgATP binding site [chemical binding]; other site 1116391012010 catalytic site [active] 1116391012011 metal binding site [ion binding]; metal-binding site 1116391012012 glycerol binding site [chemical binding]; other site 1116391012013 homotetramer interface [polypeptide binding]; other site 1116391012014 homodimer interface [polypeptide binding]; other site 1116391012015 FBP binding site [chemical binding]; other site 1116391012016 protein IIAGlc interface [polypeptide binding]; other site 1116391012017 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1116391012018 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1116391012019 PYR/PP interface [polypeptide binding]; other site 1116391012020 dimer interface [polypeptide binding]; other site 1116391012021 TPP binding site [chemical binding]; other site 1116391012022 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1116391012023 transketolase; Reviewed; Region: PRK05899 1116391012024 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1116391012025 TPP-binding site [chemical binding]; other site 1116391012026 dimer interface [polypeptide binding]; other site 1116391012027 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 1116391012028 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1116391012029 substrate binding site [chemical binding]; other site 1116391012030 trimer interface [polypeptide binding]; other site 1116391012031 Mn binding site [ion binding]; other site 1116391012032 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391012033 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391012034 DNA binding site [nucleotide binding] 1116391012035 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1116391012036 ligand binding site [chemical binding]; other site 1116391012037 dimerization interface [polypeptide binding]; other site 1116391012038 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391012039 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012040 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391012041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012042 putative alpha-glucosidase; Provisional; Region: PRK10658 1116391012043 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1116391012044 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1116391012045 active site 1116391012046 homotrimer interface [polypeptide binding]; other site 1116391012047 catalytic site [active] 1116391012048 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1116391012049 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 1116391012050 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1116391012051 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1116391012052 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1116391012053 conserved cys residue [active] 1116391012054 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1116391012055 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1116391012056 Spore germination protein; Region: Spore_permease; cl17796 1116391012057 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391012058 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391012059 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391012060 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 1116391012061 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1116391012062 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1116391012063 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391012064 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1116391012065 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1116391012066 ligand binding site [chemical binding]; other site 1116391012067 flexible hinge region; other site 1116391012068 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1116391012069 non-specific DNA interactions [nucleotide binding]; other site 1116391012070 DNA binding site [nucleotide binding] 1116391012071 sequence specific DNA binding site [nucleotide binding]; other site 1116391012072 putative cAMP binding site [chemical binding]; other site 1116391012073 DoxX-like family; Region: DoxX_2; pfam13564 1116391012074 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1116391012075 ADP-ribose binding site [chemical binding]; other site 1116391012076 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391012077 Lipocalin-like domain; Region: Lipocalin_4; pfam13648 1116391012078 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 1116391012079 MutS domain III; Region: MutS_III; pfam05192 1116391012080 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391012081 Walker A/P-loop; other site 1116391012082 ATP binding site [chemical binding]; other site 1116391012083 Q-loop/lid; other site 1116391012084 ABC transporter signature motif; other site 1116391012085 Walker B; other site 1116391012086 D-loop; other site 1116391012087 H-loop/switch region; other site 1116391012088 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1116391012089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391012090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391012091 active site 1116391012092 phosphorylation site [posttranslational modification] 1116391012093 intermolecular recognition site; other site 1116391012094 dimerization interface [polypeptide binding]; other site 1116391012095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391012096 DNA binding site [nucleotide binding] 1116391012097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391012098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391012099 dimerization interface [polypeptide binding]; other site 1116391012100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391012101 dimer interface [polypeptide binding]; other site 1116391012102 phosphorylation site [posttranslational modification] 1116391012103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391012104 ATP binding site [chemical binding]; other site 1116391012105 Mg2+ binding site [ion binding]; other site 1116391012106 G-X-G motif; other site 1116391012107 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391012108 putative substrate translocation pore; other site 1116391012109 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1116391012110 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1116391012111 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391012112 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1116391012113 dimer interface [polypeptide binding]; other site 1116391012114 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391012115 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391012116 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391012117 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391012118 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391012119 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391012120 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1116391012121 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 1116391012122 putative NAD(P) binding site [chemical binding]; other site 1116391012123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391012124 putative substrate translocation pore; other site 1116391012125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391012126 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391012127 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391012128 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1116391012129 dimerization interface [polypeptide binding]; other site 1116391012130 DNA binding domain, excisionase family; Region: excise; TIGR01764 1116391012131 PBP superfamily domain; Region: PBP_like; pfam12727 1116391012132 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1116391012133 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1116391012134 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1116391012135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012136 dimer interface [polypeptide binding]; other site 1116391012137 ABC-ATPase subunit interface; other site 1116391012138 putative PBP binding loops; other site 1116391012139 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1116391012140 Fibrobacter succinogenes paralogous family TIGR02172; Region: Fb_sc_TIGR02172 1116391012141 active site 1116391012142 substrate binding site [chemical binding]; other site 1116391012143 ATP binding site [chemical binding]; other site 1116391012144 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391012145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012146 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391012147 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391012148 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391012149 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012150 dimer interface [polypeptide binding]; other site 1116391012151 conserved gate region; other site 1116391012152 putative PBP binding loops; other site 1116391012153 ABC-ATPase subunit interface; other site 1116391012154 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391012155 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012156 dimer interface [polypeptide binding]; other site 1116391012157 conserved gate region; other site 1116391012158 ABC-ATPase subunit interface; other site 1116391012159 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1116391012160 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1116391012161 Cytochrome P450; Region: p450; cl12078 1116391012162 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391012163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391012164 active site 1116391012165 phosphorylation site [posttranslational modification] 1116391012166 intermolecular recognition site; other site 1116391012167 dimerization interface [polypeptide binding]; other site 1116391012168 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391012169 DNA binding site [nucleotide binding] 1116391012170 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391012171 dimerization interface [polypeptide binding]; other site 1116391012172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391012173 dimer interface [polypeptide binding]; other site 1116391012174 phosphorylation site [posttranslational modification] 1116391012175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391012176 ATP binding site [chemical binding]; other site 1116391012177 Mg2+ binding site [ion binding]; other site 1116391012178 G-X-G motif; other site 1116391012179 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391012180 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391012181 H+ Antiporter protein; Region: 2A0121; TIGR00900 1116391012182 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391012183 putative substrate translocation pore; other site 1116391012184 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1116391012185 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1116391012186 THF binding site; other site 1116391012187 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1116391012188 substrate binding site [chemical binding]; other site 1116391012189 THF binding site; other site 1116391012190 zinc-binding site [ion binding]; other site 1116391012191 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391012192 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391012193 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391012194 dimerization interface [polypeptide binding]; other site 1116391012195 Helix-turn-helix domain; Region: HTH_18; pfam12833 1116391012196 putative pectinesterase; Region: PLN02432; cl01911 1116391012197 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391012198 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1116391012199 metal binding site [ion binding]; metal-binding site 1116391012200 Family description; Region: VCBS; pfam13517 1116391012201 active site 1116391012202 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391012203 Interdomain contacts; other site 1116391012204 Cytokine receptor motif; other site 1116391012205 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391012206 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1116391012207 active site 1116391012208 metal binding site [ion binding]; metal-binding site 1116391012209 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391012210 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391012211 active site 1116391012212 catalytic tetrad [active] 1116391012213 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1116391012214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391012215 DNA-binding site [nucleotide binding]; DNA binding site 1116391012216 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391012217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391012218 homodimer interface [polypeptide binding]; other site 1116391012219 catalytic residue [active] 1116391012220 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1116391012221 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1116391012222 Condensation domain; Region: Condensation; pfam00668 1116391012223 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391012224 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391012225 acyl-activating enzyme (AAE) consensus motif; other site 1116391012226 AMP binding site [chemical binding]; other site 1116391012227 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391012228 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 1116391012229 Condensation domain; Region: Condensation; pfam00668 1116391012230 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391012231 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391012232 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391012233 acyl-activating enzyme (AAE) consensus motif; other site 1116391012234 AMP binding site [chemical binding]; other site 1116391012235 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391012236 Condensation domain; Region: Condensation; pfam00668 1116391012237 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391012238 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1116391012239 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1116391012240 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1116391012241 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1116391012242 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1116391012243 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1116391012244 active site 1116391012245 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1116391012246 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1116391012247 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1116391012248 putative NADP binding site [chemical binding]; other site 1116391012249 active site 1116391012250 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391012251 Condensation domain; Region: Condensation; pfam00668 1116391012252 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391012253 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1116391012254 acyl-activating enzyme (AAE) consensus motif; other site 1116391012255 AMP binding site [chemical binding]; other site 1116391012256 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391012257 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391012258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012259 dimer interface [polypeptide binding]; other site 1116391012260 conserved gate region; other site 1116391012261 putative PBP binding loops; other site 1116391012262 ABC-ATPase subunit interface; other site 1116391012263 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1116391012264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012265 putative PBP binding loops; other site 1116391012266 dimer interface [polypeptide binding]; other site 1116391012267 ABC-ATPase subunit interface; other site 1116391012268 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391012269 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391012270 Histidine kinase; Region: His_kinase; pfam06580 1116391012271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391012272 ATP binding site [chemical binding]; other site 1116391012273 Mg2+ binding site [ion binding]; other site 1116391012274 G-X-G motif; other site 1116391012275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391012276 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391012277 active site 1116391012278 phosphorylation site [posttranslational modification] 1116391012279 intermolecular recognition site; other site 1116391012280 dimerization interface [polypeptide binding]; other site 1116391012281 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391012282 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012283 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1116391012284 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1116391012285 DNA binding residues [nucleotide binding] 1116391012286 dimer interface [polypeptide binding]; other site 1116391012287 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1116391012288 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1116391012289 dimer interface [polypeptide binding]; other site 1116391012290 active site 1116391012291 catalytic residue [active] 1116391012292 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391012293 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391012294 haloalkane dehalogenase; Provisional; Region: PRK03204 1116391012295 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1116391012296 RibD C-terminal domain; Region: RibD_C; cl17279 1116391012297 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391012298 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391012299 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391012300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012301 dimer interface [polypeptide binding]; other site 1116391012302 conserved gate region; other site 1116391012303 putative PBP binding loops; other site 1116391012304 ABC-ATPase subunit interface; other site 1116391012305 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391012306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012307 dimer interface [polypeptide binding]; other site 1116391012308 conserved gate region; other site 1116391012309 putative PBP binding loops; other site 1116391012310 ABC-ATPase subunit interface; other site 1116391012311 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391012312 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391012313 dimerization interface [polypeptide binding]; other site 1116391012314 Histidine kinase; Region: His_kinase; pfam06580 1116391012315 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391012316 ATP binding site [chemical binding]; other site 1116391012317 Mg2+ binding site [ion binding]; other site 1116391012318 G-X-G motif; other site 1116391012319 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391012320 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391012321 active site 1116391012322 phosphorylation site [posttranslational modification] 1116391012323 intermolecular recognition site; other site 1116391012324 dimerization interface [polypeptide binding]; other site 1116391012325 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391012326 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012328 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1116391012329 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1116391012330 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1116391012331 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1116391012332 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1116391012333 DNA binding residues [nucleotide binding] 1116391012334 putative dimer interface [polypeptide binding]; other site 1116391012335 EamA-like transporter family; Region: EamA; cl17759 1116391012336 EamA-like transporter family; Region: EamA; pfam00892 1116391012337 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391012338 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1116391012339 active site 1116391012340 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391012341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012342 dimer interface [polypeptide binding]; other site 1116391012343 conserved gate region; other site 1116391012344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391012345 ABC-ATPase subunit interface; other site 1116391012346 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391012347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012348 dimer interface [polypeptide binding]; other site 1116391012349 conserved gate region; other site 1116391012350 putative PBP binding loops; other site 1116391012351 ABC-ATPase subunit interface; other site 1116391012352 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391012353 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391012354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391012355 active site 1116391012356 phosphorylation site [posttranslational modification] 1116391012357 intermolecular recognition site; other site 1116391012358 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012359 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391012360 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012361 Histidine kinase; Region: His_kinase; pfam06580 1116391012362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391012363 ATP binding site [chemical binding]; other site 1116391012364 Mg2+ binding site [ion binding]; other site 1116391012365 G-X-G motif; other site 1116391012366 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1116391012367 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1116391012368 active site 1116391012369 ATP binding site [chemical binding]; other site 1116391012370 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1116391012371 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391012372 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391012373 DNA binding residues [nucleotide binding] 1116391012374 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1116391012375 Cytochrome P450; Region: p450; cl12078 1116391012376 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1116391012377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391012378 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1116391012379 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1116391012380 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391012381 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012382 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391012383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012384 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1116391012385 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391012386 DNA-binding site [nucleotide binding]; DNA binding site 1116391012387 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391012388 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391012389 homodimer interface [polypeptide binding]; other site 1116391012390 catalytic residue [active] 1116391012391 glycerate kinase; Region: TIGR00045 1116391012392 CAAX protease self-immunity; Region: Abi; pfam02517 1116391012393 putative acetyltransferase; Provisional; Region: PRK03624 1116391012394 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391012395 Coenzyme A binding pocket [chemical binding]; other site 1116391012396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1116391012397 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1116391012398 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391012399 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1116391012401 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1116391012402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391012403 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391012404 active site 1116391012405 phosphorylation site [posttranslational modification] 1116391012406 intermolecular recognition site; other site 1116391012407 dimerization interface [polypeptide binding]; other site 1116391012408 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391012409 non-specific DNA binding site [nucleotide binding]; other site 1116391012410 salt bridge; other site 1116391012411 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391012412 sequence-specific DNA binding site [nucleotide binding]; other site 1116391012413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012414 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391012415 dimerization interface [polypeptide binding]; other site 1116391012416 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391012417 Histidine kinase; Region: His_kinase; pfam06580 1116391012418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391012419 ATP binding site [chemical binding]; other site 1116391012420 Mg2+ binding site [ion binding]; other site 1116391012421 G-X-G motif; other site 1116391012422 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391012423 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391012424 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1116391012425 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391012426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391012427 active site 1116391012428 phosphorylation site [posttranslational modification] 1116391012429 intermolecular recognition site; other site 1116391012430 dimerization interface [polypeptide binding]; other site 1116391012431 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391012432 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391012433 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391012434 dimerization interface [polypeptide binding]; other site 1116391012435 Histidine kinase; Region: His_kinase; pfam06580 1116391012436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391012437 ATP binding site [chemical binding]; other site 1116391012438 Mg2+ binding site [ion binding]; other site 1116391012439 G-X-G motif; other site 1116391012440 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391012441 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391012442 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391012443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012444 dimer interface [polypeptide binding]; other site 1116391012445 ABC-ATPase subunit interface; other site 1116391012446 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391012447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012448 dimer interface [polypeptide binding]; other site 1116391012449 conserved gate region; other site 1116391012450 ABC-ATPase subunit interface; other site 1116391012451 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1116391012452 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1116391012453 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391012454 Interdomain contacts; other site 1116391012455 Cytokine receptor motif; other site 1116391012456 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1116391012457 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391012458 Interdomain contacts; other site 1116391012459 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1116391012460 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1116391012461 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 1116391012462 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391012463 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391012464 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391012465 dimerization interface [polypeptide binding]; other site 1116391012466 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1116391012467 EamA-like transporter family; Region: EamA; pfam00892 1116391012468 EamA-like transporter family; Region: EamA; pfam00892 1116391012469 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391012470 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1116391012471 active site 1116391012472 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1116391012473 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1116391012474 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1116391012475 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391012476 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391012477 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1116391012478 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 1116391012479 NAD(P) binding site [chemical binding]; other site 1116391012480 active site 1116391012481 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391012482 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391012483 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391012484 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391012485 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1116391012486 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1116391012487 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1116391012488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391012489 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391012490 putative substrate translocation pore; other site 1116391012491 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1116391012492 hypothetical protein; Provisional; Region: PRK07206 1116391012493 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391012494 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1116391012495 H+ Antiporter protein; Region: 2A0121; TIGR00900 1116391012496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391012497 putative substrate translocation pore; other site 1116391012498 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1116391012499 PYR/PP interface [polypeptide binding]; other site 1116391012500 dimer interface [polypeptide binding]; other site 1116391012501 TPP binding site [chemical binding]; other site 1116391012502 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1116391012503 TPP-binding site [chemical binding]; other site 1116391012504 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1116391012505 substrate binding site [chemical binding]; other site 1116391012506 nucleotide binding site [chemical binding]; other site 1116391012507 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1116391012508 N-acetyl-ornithine/N-acetyl-lysine deacetylase; Region: dapE-lys-deAc; TIGR01902 1116391012509 metal binding site [ion binding]; metal-binding site 1116391012510 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1116391012511 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1116391012512 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 1116391012513 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1116391012514 inhibitor-cofactor binding pocket; inhibition site 1116391012515 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391012516 catalytic residue [active] 1116391012517 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1116391012518 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 1116391012519 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1116391012520 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 1116391012521 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1116391012522 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1116391012523 catalytic triad [active] 1116391012524 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1116391012525 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012526 dimer interface [polypeptide binding]; other site 1116391012527 conserved gate region; other site 1116391012528 putative PBP binding loops; other site 1116391012529 ABC-ATPase subunit interface; other site 1116391012530 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1116391012531 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012532 dimer interface [polypeptide binding]; other site 1116391012533 conserved gate region; other site 1116391012534 putative PBP binding loops; other site 1116391012535 ABC-ATPase subunit interface; other site 1116391012536 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1116391012537 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391012538 Walker A/P-loop; other site 1116391012539 ATP binding site [chemical binding]; other site 1116391012540 Q-loop/lid; other site 1116391012541 ABC transporter signature motif; other site 1116391012542 Walker B; other site 1116391012543 D-loop; other site 1116391012544 H-loop/switch region; other site 1116391012545 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1116391012546 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1116391012547 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391012548 Walker A/P-loop; other site 1116391012549 ATP binding site [chemical binding]; other site 1116391012550 Q-loop/lid; other site 1116391012551 ABC transporter signature motif; other site 1116391012552 Walker B; other site 1116391012553 D-loop; other site 1116391012554 H-loop/switch region; other site 1116391012555 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1116391012556 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1116391012557 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1116391012558 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391012559 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012560 dimer interface [polypeptide binding]; other site 1116391012561 conserved gate region; other site 1116391012562 putative PBP binding loops; other site 1116391012563 ABC-ATPase subunit interface; other site 1116391012564 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391012565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391012566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012567 putative PBP binding loops; other site 1116391012568 dimer interface [polypeptide binding]; other site 1116391012569 ABC-ATPase subunit interface; other site 1116391012570 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391012571 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391012572 Amidohydrolase; Region: Amidohydro_2; pfam04909 1116391012573 argininosuccinate lyase; Provisional; Region: PRK06705 1116391012574 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1116391012575 active sites [active] 1116391012576 tetramer interface [polypeptide binding]; other site 1116391012577 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1116391012578 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1116391012579 active site 1116391012580 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 1116391012581 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1116391012582 active site 1116391012583 dimer interface [polypeptide binding]; other site 1116391012584 non-prolyl cis peptide bond; other site 1116391012585 insertion regions; other site 1116391012586 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 1116391012587 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1116391012588 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1116391012589 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391012590 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391012591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391012592 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1116391012593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012594 dimer interface [polypeptide binding]; other site 1116391012595 conserved gate region; other site 1116391012596 putative PBP binding loops; other site 1116391012597 ABC-ATPase subunit interface; other site 1116391012598 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391012599 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391012600 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1116391012601 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 1116391012602 active site 1116391012603 dimer interface [polypeptide binding]; other site 1116391012604 non-prolyl cis peptide bond; other site 1116391012605 insertion regions; other site 1116391012606 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391012607 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391012608 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012609 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012611 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391012612 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012613 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1116391012614 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391012615 NAD(P) binding site [chemical binding]; other site 1116391012616 active site 1116391012617 SnoaL-like domain; Region: SnoaL_4; pfam13577 1116391012618 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 1116391012619 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1116391012620 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1116391012621 active site 1116391012622 non-prolyl cis peptide bond; other site 1116391012623 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 1116391012624 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1116391012625 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1116391012626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391012627 Coenzyme A binding pocket [chemical binding]; other site 1116391012628 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1116391012629 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1116391012630 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1116391012631 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1116391012632 metal binding site [ion binding]; metal-binding site 1116391012633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391012634 Coenzyme A binding pocket [chemical binding]; other site 1116391012635 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1116391012636 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1116391012637 Walker A/P-loop; other site 1116391012638 ATP binding site [chemical binding]; other site 1116391012639 Q-loop/lid; other site 1116391012640 ABC transporter signature motif; other site 1116391012641 Walker B; other site 1116391012642 D-loop; other site 1116391012643 H-loop/switch region; other site 1116391012644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012645 dimer interface [polypeptide binding]; other site 1116391012646 conserved gate region; other site 1116391012647 putative PBP binding loops; other site 1116391012648 ABC-ATPase subunit interface; other site 1116391012649 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1116391012650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012651 dimer interface [polypeptide binding]; other site 1116391012652 conserved gate region; other site 1116391012653 putative PBP binding loops; other site 1116391012654 ABC-ATPase subunit interface; other site 1116391012655 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1116391012656 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391012657 substrate binding pocket [chemical binding]; other site 1116391012658 membrane-bound complex binding site; other site 1116391012659 hinge residues; other site 1116391012660 DinB superfamily; Region: DinB_2; pfam12867 1116391012661 metal-dependent hydrolase; Provisional; Region: PRK13291 1116391012662 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391012663 Q-loop/lid; other site 1116391012664 ABC transporter signature motif; other site 1116391012665 Walker B; other site 1116391012666 D-loop; other site 1116391012667 H-loop/switch region; other site 1116391012668 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1116391012669 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391012670 Walker A/P-loop; other site 1116391012671 ATP binding site [chemical binding]; other site 1116391012672 Q-loop/lid; other site 1116391012673 ABC transporter signature motif; other site 1116391012674 Walker B; other site 1116391012675 D-loop; other site 1116391012676 H-loop/switch region; other site 1116391012677 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1116391012678 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1116391012679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012680 ABC-ATPase subunit interface; other site 1116391012681 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1116391012682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012683 dimer interface [polypeptide binding]; other site 1116391012684 conserved gate region; other site 1116391012685 putative PBP binding loops; other site 1116391012686 ABC-ATPase subunit interface; other site 1116391012687 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1116391012688 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 1116391012689 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1116391012690 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1116391012691 active site 1116391012692 non-prolyl cis peptide bond; other site 1116391012693 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1116391012694 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1116391012695 cell density-dependent motility repressor; Provisional; Region: PRK10082 1116391012696 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391012697 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391012698 dimerization interface [polypeptide binding]; other site 1116391012699 DoxX-like family; Region: DoxX_2; pfam13564 1116391012700 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1116391012701 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1116391012702 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1116391012703 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1116391012704 Sulfatase; Region: Sulfatase; pfam00884 1116391012705 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1116391012706 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1116391012707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012708 dimer interface [polypeptide binding]; other site 1116391012709 conserved gate region; other site 1116391012710 putative PBP binding loops; other site 1116391012711 ABC-ATPase subunit interface; other site 1116391012712 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1116391012713 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1116391012714 Walker A/P-loop; other site 1116391012715 ATP binding site [chemical binding]; other site 1116391012716 Q-loop/lid; other site 1116391012717 ABC transporter signature motif; other site 1116391012718 Walker B; other site 1116391012719 D-loop; other site 1116391012720 H-loop/switch region; other site 1116391012721 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1116391012722 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391012723 substrate binding pocket [chemical binding]; other site 1116391012724 membrane-bound complex binding site; other site 1116391012725 hinge residues; other site 1116391012726 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391012727 MarR family; Region: MarR; pfam01047 1116391012728 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1116391012729 Sulfatase; Region: Sulfatase; cl17466 1116391012730 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391012731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391012732 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391012733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012734 dimer interface [polypeptide binding]; other site 1116391012735 conserved gate region; other site 1116391012736 ABC-ATPase subunit interface; other site 1116391012737 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391012738 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320 1116391012739 active site 1116391012740 catalytic site [active] 1116391012741 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 1116391012742 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 1116391012743 Ca binding site [ion binding]; other site 1116391012744 substrate binding site [chemical binding]; other site 1116391012745 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391012746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012747 Helix-turn-helix domain; Region: HTH_18; pfam12833 1116391012748 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012749 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 1116391012750 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1116391012751 active site 1116391012752 non-prolyl cis peptide bond; other site 1116391012753 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1116391012754 active site 1116391012755 metal binding site [ion binding]; metal-binding site 1116391012756 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391012757 RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950 1116391012758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391012759 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1116391012760 DNA binding residues [nucleotide binding] 1116391012761 Lactoylglutathione lyase and related lyases [Amino acid transport and metabolism]; Region: GloA; COG0346 1116391012762 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 1116391012763 nudix motif; other site 1116391012764 C factor cell-cell signaling protein; Provisional; Region: PRK09009 1116391012765 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 1116391012766 NADP binding site [chemical binding]; other site 1116391012767 homodimer interface [polypeptide binding]; other site 1116391012768 active site 1116391012769 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 1116391012770 dimer interface [polypeptide binding]; other site 1116391012771 substrate binding site [chemical binding]; other site 1116391012772 metal binding site [ion binding]; metal-binding site 1116391012773 Protein of unknown function (DUF817); Region: DUF817; pfam05675 1116391012774 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1116391012775 metal-binding site [ion binding] 1116391012776 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391012777 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391012778 DNA binding site [nucleotide binding] 1116391012779 domain linker motif; other site 1116391012780 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1116391012781 dimerization interface [polypeptide binding]; other site 1116391012782 ligand binding site [chemical binding]; other site 1116391012783 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391012784 dimerization interface [polypeptide binding]; other site 1116391012785 putative DNA binding site [nucleotide binding]; other site 1116391012786 putative Zn2+ binding site [ion binding]; other site 1116391012787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391012788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391012789 dimer interface [polypeptide binding]; other site 1116391012790 phosphorylation site [posttranslational modification] 1116391012791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391012792 ATP binding site [chemical binding]; other site 1116391012793 Mg2+ binding site [ion binding]; other site 1116391012794 G-X-G motif; other site 1116391012795 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391012796 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391012797 active site 1116391012798 phosphorylation site [posttranslational modification] 1116391012799 intermolecular recognition site; other site 1116391012800 dimerization interface [polypeptide binding]; other site 1116391012801 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391012802 DNA binding site [nucleotide binding] 1116391012803 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1116391012804 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1116391012805 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1116391012806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391012807 Walker A/P-loop; other site 1116391012808 ATP binding site [chemical binding]; other site 1116391012809 Q-loop/lid; other site 1116391012810 ABC transporter signature motif; other site 1116391012811 Walker B; other site 1116391012812 D-loop; other site 1116391012813 H-loop/switch region; other site 1116391012814 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391012815 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391012816 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1116391012817 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1116391012818 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391012819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012820 dimer interface [polypeptide binding]; other site 1116391012821 conserved gate region; other site 1116391012822 putative PBP binding loops; other site 1116391012823 ABC-ATPase subunit interface; other site 1116391012824 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1116391012825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391012826 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391012827 putative PBP binding loops; other site 1116391012828 dimer interface [polypeptide binding]; other site 1116391012829 ABC-ATPase subunit interface; other site 1116391012830 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391012831 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391012832 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391012833 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391012834 active site 1116391012835 phosphorylation site [posttranslational modification] 1116391012836 intermolecular recognition site; other site 1116391012837 dimerization interface [polypeptide binding]; other site 1116391012838 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012839 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391012840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012841 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391012842 HAMP domain; Region: HAMP; pfam00672 1116391012843 Histidine kinase; Region: His_kinase; pfam06580 1116391012844 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391012845 ATP binding site [chemical binding]; other site 1116391012846 Mg2+ binding site [ion binding]; other site 1116391012847 G-X-G motif; other site 1116391012848 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1116391012849 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1116391012850 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1116391012851 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1116391012852 active site 1116391012853 Transposase domain (DUF772); Region: DUF772; pfam05598 1116391012854 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1116391012855 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1116391012856 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1116391012857 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1116391012858 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391012859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391012860 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1116391012861 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391012862 DNA-binding site [nucleotide binding]; DNA binding site 1116391012863 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391012864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391012865 homodimer interface [polypeptide binding]; other site 1116391012866 catalytic residue [active] 1116391012867 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1116391012868 EamA-like transporter family; Region: EamA; pfam00892 1116391012869 EamA-like transporter family; Region: EamA; pfam00892 1116391012870 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1116391012871 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1116391012872 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1116391012873 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1116391012874 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1116391012875 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391012876 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391012877 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391012878 active site 1116391012879 catalytic tetrad [active] 1116391012880 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391012881 Spore germination protein; Region: Spore_permease; cl17796 1116391012882 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391012883 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391012884 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1116391012885 putative trimer interface [polypeptide binding]; other site 1116391012886 putative CoA binding site [chemical binding]; other site 1116391012887 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1116391012888 putative trimer interface [polypeptide binding]; other site 1116391012889 putative CoA binding site [chemical binding]; other site 1116391012890 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1116391012891 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1116391012892 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1116391012893 Walker A/P-loop; other site 1116391012894 ATP binding site [chemical binding]; other site 1116391012895 Q-loop/lid; other site 1116391012896 ABC transporter signature motif; other site 1116391012897 Walker B; other site 1116391012898 D-loop; other site 1116391012899 H-loop/switch region; other site 1116391012900 Condensation domain; Region: Condensation; pfam00668 1116391012901 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391012902 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1116391012903 acyl-activating enzyme (AAE) consensus motif; other site 1116391012904 AMP binding site [chemical binding]; other site 1116391012905 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391012906 Condensation domain; Region: Condensation; pfam00668 1116391012907 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391012908 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391012909 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391012910 acyl-activating enzyme (AAE) consensus motif; other site 1116391012911 AMP binding site [chemical binding]; other site 1116391012912 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391012913 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1116391012914 acyl-activating enzyme (AAE) consensus motif; other site 1116391012915 AMP binding site [chemical binding]; other site 1116391012916 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391012917 Condensation domain; Region: Condensation; pfam00668 1116391012918 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391012919 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391012920 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1116391012921 acyl-activating enzyme (AAE) consensus motif; other site 1116391012922 AMP binding site [chemical binding]; other site 1116391012923 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391012924 Condensation domain; Region: Condensation; pfam00668 1116391012925 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1116391012926 Condensation domain; Region: Condensation; pfam00668 1116391012927 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391012928 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391012929 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1116391012930 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1116391012931 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1116391012932 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1116391012933 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1116391012934 trimer interface [polypeptide binding]; other site 1116391012935 active site 1116391012936 substrate binding site [chemical binding]; other site 1116391012937 CoA binding site [chemical binding]; other site 1116391012938 H+ Antiporter protein; Region: 2A0121; TIGR00900 1116391012939 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 1116391012940 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1116391012941 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 1116391012942 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1116391012943 dimer interface [polypeptide binding]; other site 1116391012944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391012945 catalytic residue [active] 1116391012946 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391012947 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391012948 active site 1116391012949 phosphorylation site [posttranslational modification] 1116391012950 dimerization interface [polypeptide binding]; other site 1116391012951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391012952 DNA binding site [nucleotide binding] 1116391012953 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1116391012954 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1116391012955 NAD binding site [chemical binding]; other site 1116391012956 homotetramer interface [polypeptide binding]; other site 1116391012957 homodimer interface [polypeptide binding]; other site 1116391012958 substrate binding site [chemical binding]; other site 1116391012959 active site 1116391012960 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1116391012961 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1116391012962 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 1116391012963 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 1116391012964 dimer interface [polypeptide binding]; other site 1116391012965 active site 1116391012966 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1116391012967 catalytic residues [active] 1116391012968 substrate binding site [chemical binding]; other site 1116391012969 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1116391012970 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1116391012971 active site 1116391012972 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1116391012973 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1116391012974 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1116391012975 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1116391012976 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391012977 Walker A/P-loop; other site 1116391012978 ATP binding site [chemical binding]; other site 1116391012979 Q-loop/lid; other site 1116391012980 ABC transporter signature motif; other site 1116391012981 Walker B; other site 1116391012982 D-loop; other site 1116391012983 H-loop/switch region; other site 1116391012984 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391012985 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391012986 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 1116391012987 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391012988 FeS/SAM binding site; other site 1116391012989 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1116391012990 diacylglycerol glucosyltransferase; Provisional; Region: PRK13608 1116391012991 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1116391012992 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1116391012993 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1116391012994 substrate binding site [chemical binding]; other site 1116391012995 active site 1116391012996 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1116391012997 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391012998 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391012999 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 1116391013000 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 1116391013001 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1116391013002 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1116391013003 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1116391013004 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1116391013005 cyclase homology domain; Region: CHD; cd07302 1116391013006 nucleotidyl binding site; other site 1116391013007 metal binding site [ion binding]; metal-binding site 1116391013008 dimer interface [polypeptide binding]; other site 1116391013009 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 1116391013010 cyclase homology domain; Region: CHD; cd07302 1116391013011 nucleotidyl binding site; other site 1116391013012 metal binding site [ion binding]; metal-binding site 1116391013013 dimer interface [polypeptide binding]; other site 1116391013014 Predicted ATPase [General function prediction only]; Region: COG3899 1116391013015 AAA ATPase domain; Region: AAA_16; pfam13191 1116391013016 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1116391013017 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1116391013018 sulfite reductase subunit beta; Provisional; Region: PRK13504 1116391013019 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1116391013020 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1116391013021 sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931 1116391013022 Flavodoxin; Region: Flavodoxin_1; pfam00258 1116391013023 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1116391013024 FAD binding pocket [chemical binding]; other site 1116391013025 FAD binding motif [chemical binding]; other site 1116391013026 catalytic residues [active] 1116391013027 NAD binding pocket [chemical binding]; other site 1116391013028 phosphate binding motif [ion binding]; other site 1116391013029 beta-alpha-beta structure motif; other site 1116391013030 Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237 1116391013031 Calx-beta domain; Region: Calx-beta; pfam03160 1116391013032 Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237 1116391013033 Calx-beta domain; Region: Calx-beta; cl02522 1116391013034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391013035 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1116391013036 Walker A motif; other site 1116391013037 ATP binding site [chemical binding]; other site 1116391013038 Walker B motif; other site 1116391013039 arginine finger; other site 1116391013040 UvrB/uvrC motif; Region: UVR; pfam02151 1116391013041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391013042 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1116391013043 Walker A motif; other site 1116391013044 ATP binding site [chemical binding]; other site 1116391013045 Walker B motif; other site 1116391013046 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1116391013047 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391013048 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391013049 CHASE3 domain; Region: CHASE3; cl05000 1116391013050 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391013051 dimerization interface [polypeptide binding]; other site 1116391013052 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391013053 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391013054 dimer interface [polypeptide binding]; other site 1116391013055 putative CheW interface [polypeptide binding]; other site 1116391013056 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391013057 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1116391013058 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1116391013059 Predicted transcriptional regulator [Transcription]; Region: COG2378 1116391013060 HTH domain; Region: HTH_11; pfam08279 1116391013061 WYL domain; Region: WYL; pfam13280 1116391013062 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391013063 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391013064 Spore germination protein; Region: Spore_permease; cl17796 1116391013065 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391013066 Chromate resistance exported protein; Region: Chrome_Resist; pfam09828 1116391013067 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 1116391013068 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 1116391013069 Chromate transporter; Region: Chromate_transp; pfam02417 1116391013070 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1116391013071 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391013072 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391013073 dimer interface [polypeptide binding]; other site 1116391013074 phosphorylation site [posttranslational modification] 1116391013075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391013076 ATP binding site [chemical binding]; other site 1116391013077 Mg2+ binding site [ion binding]; other site 1116391013078 G-X-G motif; other site 1116391013079 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391013080 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391013081 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1116391013082 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1116391013083 acyl-activating enzyme (AAE) consensus motif; other site 1116391013084 AMP binding site [chemical binding]; other site 1116391013085 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391013086 Condensation domain; Region: Condensation; pfam00668 1116391013087 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391013088 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391013089 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1116391013090 acyl-activating enzyme (AAE) consensus motif; other site 1116391013091 AMP binding site [chemical binding]; other site 1116391013092 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391013093 Condensation domain; Region: Condensation; pfam00668 1116391013094 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391013095 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1116391013096 Condensation domain; Region: Condensation; pfam00668 1116391013097 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391013098 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391013099 acyl-activating enzyme (AAE) consensus motif; other site 1116391013100 AMP binding site [chemical binding]; other site 1116391013101 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391013102 Thioesterase domain; Region: Thioesterase; pfam00975 1116391013103 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391013104 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391013105 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1116391013106 acyl-activating enzyme (AAE) consensus motif; other site 1116391013107 AMP binding site [chemical binding]; other site 1116391013108 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391013109 Condensation domain; Region: Condensation; pfam00668 1116391013110 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391013111 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391013112 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391013113 acyl-activating enzyme (AAE) consensus motif; other site 1116391013114 AMP binding site [chemical binding]; other site 1116391013115 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391013116 Condensation domain; Region: Condensation; pfam00668 1116391013117 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391013118 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1116391013119 Condensation domain; Region: Condensation; pfam00668 1116391013120 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391013121 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391013122 acyl-activating enzyme (AAE) consensus motif; other site 1116391013123 AMP binding site [chemical binding]; other site 1116391013124 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391013125 Condensation domain; Region: Condensation; pfam00668 1116391013126 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391013127 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391013128 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391013129 acyl-activating enzyme (AAE) consensus motif; other site 1116391013130 AMP binding site [chemical binding]; other site 1116391013131 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391013132 Condensation domain; Region: Condensation; pfam00668 1116391013133 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391013134 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391013135 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391013136 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391013137 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 1116391013138 Walker A/P-loop; other site 1116391013139 ATP binding site [chemical binding]; other site 1116391013140 Q-loop/lid; other site 1116391013141 ABC transporter signature motif; other site 1116391013142 Walker B; other site 1116391013143 D-loop; other site 1116391013144 H-loop/switch region; other site 1116391013145 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1116391013146 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1116391013147 inhibitor-cofactor binding pocket; inhibition site 1116391013148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391013149 catalytic residue [active] 1116391013150 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1116391013151 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1116391013152 metal ion-dependent adhesion site (MIDAS); other site 1116391013153 MoxR-like ATPases [General function prediction only]; Region: COG0714 1116391013154 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1116391013155 Walker A motif; other site 1116391013156 ATP binding site [chemical binding]; other site 1116391013157 Walker B motif; other site 1116391013158 arginine finger; other site 1116391013159 SWIM zinc finger; Region: SWIM; pfam04434 1116391013160 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 1116391013161 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1116391013162 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1116391013163 active site 1116391013164 ATP binding site [chemical binding]; other site 1116391013165 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1116391013166 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 1116391013167 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1116391013168 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 1116391013169 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391013170 FeS/SAM binding site; other site 1116391013171 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1116391013172 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1116391013173 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 1116391013174 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1116391013175 CPxP motif; other site 1116391013176 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1116391013177 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1116391013178 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1116391013179 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1116391013180 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391013181 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391013182 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1116391013183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391013184 putative substrate translocation pore; other site 1116391013185 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1116391013186 Phosphotransferase enzyme family; Region: APH; pfam01636 1116391013187 putative active site [active] 1116391013188 putative substrate binding site [chemical binding]; other site 1116391013189 ATP binding site [chemical binding]; other site 1116391013190 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1116391013191 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1116391013192 dimer interface [polypeptide binding]; other site 1116391013193 active site 1116391013194 aminoglycoside resistance protein; Provisional; Region: PRK13746 1116391013195 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1116391013196 active site 1116391013197 NTP binding site [chemical binding]; other site 1116391013198 metal binding triad [ion binding]; metal-binding site 1116391013199 antibiotic binding site [chemical binding]; other site 1116391013200 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1116391013201 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1116391013202 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391013203 S-adenosylmethionine binding site [chemical binding]; other site 1116391013204 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 1116391013205 Cellulose binding domain; Region: CBM_3; pfam00942 1116391013206 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1116391013207 hypothetical protein; Provisional; Region: PRK12378 1116391013208 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391013209 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1116391013210 acyl-activating enzyme (AAE) consensus motif; other site 1116391013211 AMP binding site [chemical binding]; other site 1116391013212 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1116391013213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391013214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391013215 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1116391013216 putative dimerization interface [polypeptide binding]; other site 1116391013217 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1116391013218 Amidohydrolase; Region: Amidohydro_2; pfam04909 1116391013219 active site 1116391013220 Predicted metalloprotease [General function prediction only]; Region: COG2321 1116391013221 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1116391013222 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1116391013223 H+ Antiporter protein; Region: 2A0121; TIGR00900 1116391013224 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391013225 putative substrate translocation pore; other site 1116391013226 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 1116391013227 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1116391013228 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 1116391013229 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1116391013230 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391013231 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391013232 acyl-activating enzyme (AAE) consensus motif; other site 1116391013233 AMP binding site [chemical binding]; other site 1116391013234 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391013235 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 1116391013236 active site 1116391013237 Condensation domain; Region: Condensation; pfam00668 1116391013238 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391013239 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391013240 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391013241 acyl-activating enzyme (AAE) consensus motif; other site 1116391013242 AMP binding site [chemical binding]; other site 1116391013243 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391013244 Condensation domain; Region: Condensation; pfam00668 1116391013245 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391013246 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391013247 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391013248 acyl-activating enzyme (AAE) consensus motif; other site 1116391013249 AMP binding site [chemical binding]; other site 1116391013250 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391013251 acyl-CoA synthetase; Validated; Region: PRK05850 1116391013252 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1116391013253 acyl-activating enzyme (AAE) consensus motif; other site 1116391013254 active site 1116391013255 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1116391013256 Condensation domain; Region: Condensation; pfam00668 1116391013257 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1116391013258 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1116391013259 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1116391013260 acyl-activating enzyme (AAE) consensus motif; other site 1116391013261 AMP binding site [chemical binding]; other site 1116391013262 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1116391013263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391013264 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391013265 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391013266 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1116391013267 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1116391013268 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1116391013269 active site 1116391013270 Zn binding site [ion binding]; other site 1116391013271 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1116391013272 dimer interface [polypeptide binding]; other site 1116391013273 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391013274 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391013275 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1116391013276 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1116391013277 Class I aldolases; Region: Aldolase_Class_I; cl17187 1116391013278 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1116391013279 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1116391013280 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1116391013281 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 1116391013282 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 1116391013283 dimer interface [polypeptide binding]; other site 1116391013284 PYR/PP interface [polypeptide binding]; other site 1116391013285 TPP binding site [chemical binding]; other site 1116391013286 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1116391013287 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 1116391013288 TPP-binding site [chemical binding]; other site 1116391013289 dimer interface [polypeptide binding]; other site 1116391013290 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1116391013291 Cache domain; Region: Cache_1; pfam02743 1116391013292 HAMP domain; Region: HAMP; pfam00672 1116391013293 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391013294 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391013295 metal binding site [ion binding]; metal-binding site 1116391013296 active site 1116391013297 I-site; other site 1116391013298 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1116391013299 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1116391013300 Part of AAA domain; Region: AAA_19; pfam13245 1116391013301 Family description; Region: UvrD_C_2; pfam13538 1116391013302 putative transporter; Provisional; Region: PRK11021 1116391013303 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1116391013304 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391013305 DNA-binding site [nucleotide binding]; DNA binding site 1116391013306 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391013307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391013308 homodimer interface [polypeptide binding]; other site 1116391013309 catalytic residue [active] 1116391013310 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391013311 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1116391013312 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1116391013313 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391013314 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 1116391013315 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1116391013316 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1116391013317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1116391013318 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 1116391013319 Propionate catabolism activator; Region: PrpR_N; pfam06506 1116391013320 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1116391013321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391013322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1116391013323 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1116391013324 Chitin binding domain; Region: Chitin_bind_3; pfam03067 1116391013325 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1116391013326 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1116391013327 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1116391013328 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391013329 Interdomain contacts; other site 1116391013330 Cytokine receptor motif; other site 1116391013331 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1116391013332 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1116391013333 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391013334 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391013335 DNA binding site [nucleotide binding] 1116391013336 domain linker motif; other site 1116391013337 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1116391013338 dimerization interface [polypeptide binding]; other site 1116391013339 ligand binding site [chemical binding]; other site 1116391013340 tellurium resistance terB-like protein; Region: terB_like; cl11965 1116391013341 metal binding site [ion binding]; metal-binding site 1116391013342 Cytochrome P450; Region: p450; pfam00067 1116391013343 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1116391013344 DinB superfamily; Region: DinB_2; pfam12867 1116391013345 protoporphyrinogen oxidase; Provisional; Region: PRK12416 1116391013346 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1116391013347 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1116391013348 VanZ like family; Region: VanZ; cl01971 1116391013349 RDD family; Region: RDD; pfam06271 1116391013350 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1116391013351 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1116391013352 substrate binding site [chemical binding]; other site 1116391013353 catalytic residues [active] 1116391013354 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391013355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391013356 active site 1116391013357 phosphorylation site [posttranslational modification] 1116391013358 intermolecular recognition site; other site 1116391013359 dimerization interface [polypeptide binding]; other site 1116391013360 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391013361 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391013362 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1116391013363 dimerization interface [polypeptide binding]; other site 1116391013364 Histidine kinase; Region: His_kinase; pfam06580 1116391013365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391013366 ATP binding site [chemical binding]; other site 1116391013367 Mg2+ binding site [ion binding]; other site 1116391013368 G-X-G motif; other site 1116391013369 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391013370 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391013371 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391013372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391013373 dimer interface [polypeptide binding]; other site 1116391013374 conserved gate region; other site 1116391013375 putative PBP binding loops; other site 1116391013376 ABC-ATPase subunit interface; other site 1116391013377 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1116391013378 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391013379 dimer interface [polypeptide binding]; other site 1116391013380 conserved gate region; other site 1116391013381 putative PBP binding loops; other site 1116391013382 ABC-ATPase subunit interface; other site 1116391013383 Domain of unknown function (DUF4306); Region: DUF4306; pfam14154 1116391013384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391013385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391013386 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1116391013387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391013388 putative substrate translocation pore; other site 1116391013389 CutC family; Region: CutC; cl01218 1116391013390 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1116391013391 RNAase interaction site [polypeptide binding]; other site 1116391013392 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1116391013393 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1116391013394 NAD binding site [chemical binding]; other site 1116391013395 dimer interface [polypeptide binding]; other site 1116391013396 substrate binding site [chemical binding]; other site 1116391013397 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1116391013398 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1116391013399 Nicotianamine synthase protein; Region: NAS; cl17658 1116391013400 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1116391013401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1116391013402 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1116391013403 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 1116391013404 malonyl-CoA binding site [chemical binding]; other site 1116391013405 dimer interface [polypeptide binding]; other site 1116391013406 active site 1116391013407 product binding site; other site 1116391013408 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 1116391013409 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1116391013410 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1116391013411 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1116391013412 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1116391013413 [2Fe-2S] cluster binding site [ion binding]; other site 1116391013414 Mannitol repressor; Region: MtlR; cl11450 1116391013415 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1116391013416 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1116391013417 NADP binding site [chemical binding]; other site 1116391013418 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1116391013419 Phloem protein 2; Region: PP2; pfam14299 1116391013420 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1116391013421 Protein of unknown function (DUF975); Region: DUF975; cl10504 1116391013422 S-layer homology domain; Region: SLH; pfam00395 1116391013423 S-layer homology domain; Region: SLH; pfam00395 1116391013424 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1116391013425 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1116391013426 Peptidase family M23; Region: Peptidase_M23; pfam01551 1116391013427 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1116391013428 Spore germination protein; Region: Spore_permease; cl17796 1116391013429 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391013430 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391013431 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1116391013432 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 1116391013433 active site 1116391013434 catalytic triad [active] 1116391013435 dimer interface [polypeptide binding]; other site 1116391013436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1116391013437 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1116391013438 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1116391013439 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391013440 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391013441 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 1116391013442 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 1116391013443 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1116391013444 minor groove reading motif; other site 1116391013445 helix-hairpin-helix signature motif; other site 1116391013446 substrate binding pocket [chemical binding]; other site 1116391013447 active site 1116391013448 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1116391013449 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1116391013450 DNA binding site [nucleotide binding] 1116391013451 active site 1116391013452 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1116391013453 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1116391013454 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1116391013455 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1116391013456 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1116391013457 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 1116391013458 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391013459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391013460 putative substrate translocation pore; other site 1116391013461 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1116391013462 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391013463 heat shock protein 90; Provisional; Region: PRK05218 1116391013464 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391013465 ATP binding site [chemical binding]; other site 1116391013466 Mg2+ binding site [ion binding]; other site 1116391013467 G-X-G motif; other site 1116391013468 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 1116391013469 substrate binding pocket [chemical binding]; other site 1116391013470 substrate-Mg2+ binding site; other site 1116391013471 aspartate-rich region 1; other site 1116391013472 aspartate-rich region 2; other site 1116391013473 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1116391013474 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1116391013475 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1116391013476 short chain dehydrogenase; Provisional; Region: PRK07062 1116391013477 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391013478 NAD(P) binding site [chemical binding]; other site 1116391013479 active site 1116391013480 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1116391013481 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1116391013482 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1116391013483 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1116391013484 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1116391013485 phosphopentomutase; Provisional; Region: PRK05362 1116391013486 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1116391013487 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1116391013488 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1116391013489 Nucleoside recognition; Region: Gate; pfam07670 1116391013490 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1116391013491 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1116391013492 active site 1116391013493 catalytic motif [active] 1116391013494 Zn binding site [ion binding]; other site 1116391013495 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1116391013496 intersubunit interface [polypeptide binding]; other site 1116391013497 active site 1116391013498 catalytic residue [active] 1116391013499 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1116391013500 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 1116391013501 non-specific DNA interactions [nucleotide binding]; other site 1116391013502 DNA binding site [nucleotide binding] 1116391013503 sequence specific DNA binding site [nucleotide binding]; other site 1116391013504 putative cAMP binding site [chemical binding]; other site 1116391013505 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1116391013506 DNA polymerase III subunit beta; Validated; Region: PRK05643 1116391013507 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1116391013508 putative DNA binding surface [nucleotide binding]; other site 1116391013509 dimer interface [polypeptide binding]; other site 1116391013510 beta-clamp/clamp loader binding surface; other site 1116391013511 beta-clamp/translesion DNA polymerase binding surface; other site 1116391013512 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1116391013513 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1116391013514 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1116391013515 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1116391013516 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1116391013517 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1116391013518 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1116391013519 dimer interface [polypeptide binding]; other site 1116391013520 FMN binding site [chemical binding]; other site 1116391013521 Rrf2 family protein; Region: rrf2_super; TIGR00738 1116391013522 Transcriptional regulator; Region: Rrf2; pfam02082 1116391013523 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1116391013524 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1116391013525 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1116391013526 substrate binding site [chemical binding]; other site 1116391013527 active site 1116391013528 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1116391013529 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1116391013530 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391013531 Phytochelatin synthase; Region: Phytochelatin; pfam05023 1116391013532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391013533 dimer interface [polypeptide binding]; other site 1116391013534 conserved gate region; other site 1116391013535 putative PBP binding loops; other site 1116391013536 ABC-ATPase subunit interface; other site 1116391013537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391013538 dimer interface [polypeptide binding]; other site 1116391013539 conserved gate region; other site 1116391013540 ABC-ATPase subunit interface; other site 1116391013541 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391013542 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391013543 Predicted transcriptional regulator [Transcription]; Region: COG4189 1116391013544 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391013545 dimerization interface [polypeptide binding]; other site 1116391013546 putative DNA binding site [nucleotide binding]; other site 1116391013547 putative Zn2+ binding site [ion binding]; other site 1116391013548 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1116391013549 NlpC/P60 family; Region: NLPC_P60; pfam00877 1116391013550 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1116391013551 active site 1116391013552 catalytic triad [active] 1116391013553 ParB-like nuclease domain; Region: ParBc; pfam02195 1116391013554 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391013555 PAS domain; Region: PAS_9; pfam13426 1116391013556 putative active site [active] 1116391013557 heme pocket [chemical binding]; other site 1116391013558 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1116391013559 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1116391013560 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391013561 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391013562 Interdomain contacts; other site 1116391013563 Cytokine receptor motif; other site 1116391013564 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1116391013565 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 1116391013566 Moco binding site; other site 1116391013567 metal coordination site [ion binding]; other site 1116391013568 YolD-like protein; Region: YolD; pfam08863 1116391013569 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1116391013570 dimer interface [polypeptide binding]; other site 1116391013571 [2Fe-2S] cluster binding site [ion binding]; other site 1116391013572 sugar efflux transporter; Region: 2A0120; TIGR00899 1116391013573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391013574 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1116391013575 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1116391013576 ligand binding site [chemical binding]; other site 1116391013577 flexible hinge region; other site 1116391013578 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1116391013579 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1116391013580 DoxX-like family; Region: DoxX_3; pfam13781 1116391013581 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1116391013582 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 1116391013583 DNA binding residues [nucleotide binding] 1116391013584 putative dimer interface [polypeptide binding]; other site 1116391013585 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1116391013586 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1116391013587 catalytic residues [active] 1116391013588 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1116391013589 Domain of unknown function DUF21; Region: DUF21; pfam01595 1116391013590 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1116391013591 Transporter associated domain; Region: CorC_HlyC; smart01091 1116391013592 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1116391013593 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391013594 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391013595 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1116391013596 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391013597 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1116391013598 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1116391013599 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1116391013600 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391013601 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391013602 putative substrate translocation pore; other site 1116391013603 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391013604 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1116391013605 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1116391013606 protein binding site [polypeptide binding]; other site 1116391013607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391013608 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1116391013609 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1116391013610 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391013611 NAD(P) binding site [chemical binding]; other site 1116391013612 active site 1116391013613 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1116391013614 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1116391013615 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1116391013616 active site 1116391013617 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391013618 S-adenosylmethionine binding site [chemical binding]; other site 1116391013619 putative phosphoesterase; Region: acc_ester; TIGR03729 1116391013620 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391013621 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1116391013622 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 1116391013623 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1116391013624 Nitronate monooxygenase; Region: NMO; pfam03060 1116391013625 FMN binding site [chemical binding]; other site 1116391013626 substrate binding site [chemical binding]; other site 1116391013627 putative catalytic residue [active] 1116391013628 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391013629 Coenzyme A binding pocket [chemical binding]; other site 1116391013630 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391013631 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 1116391013632 S-layer homology domain; Region: SLH; pfam00395 1116391013633 S-layer homology domain; Region: SLH; pfam00395 1116391013634 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 1116391013635 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1116391013636 protein binding site [polypeptide binding]; other site 1116391013637 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 1116391013638 Active site serine [active] 1116391013639 Bacterial Ig-like domain; Region: Big_5; pfam13205 1116391013640 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1116391013641 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1116391013642 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391013643 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1116391013644 Walker A/P-loop; other site 1116391013645 ATP binding site [chemical binding]; other site 1116391013646 Q-loop/lid; other site 1116391013647 ABC transporter signature motif; other site 1116391013648 Walker B; other site 1116391013649 D-loop; other site 1116391013650 H-loop/switch region; other site 1116391013651 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391013652 Coenzyme A binding pocket [chemical binding]; other site 1116391013653 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1116391013654 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1116391013655 anti sigma factor interaction site; other site 1116391013656 regulatory phosphorylation site [posttranslational modification]; other site 1116391013657 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1116391013658 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391013659 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391013660 active site 1116391013661 phosphorylation site [posttranslational modification] 1116391013662 intermolecular recognition site; other site 1116391013663 dimerization interface [polypeptide binding]; other site 1116391013664 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1116391013665 VPS10 domain; Region: VPS10; smart00602 1116391013666 VPS10 domain; Region: VPS10; smart00602 1116391013667 BNR repeat-like domain; Region: BNR_2; pfam13088 1116391013668 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 1116391013669 FAD dependent oxidoreductase; Region: DAO; pfam01266 1116391013670 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1116391013671 DNA-binding site [nucleotide binding]; DNA binding site 1116391013672 RNA-binding motif; other site 1116391013673 Rhomboid family; Region: Rhomboid; pfam01694 1116391013674 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1116391013675 Coat F domain; Region: Coat_F; pfam07875 1116391013676 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391013677 active site 1116391013678 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391013679 catalytic tetrad [active] 1116391013680 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1116391013681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391013682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391013683 Ion channel; Region: Ion_trans_2; pfam07885 1116391013684 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1116391013685 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1116391013686 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1116391013687 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1116391013688 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391013689 Walker A/P-loop; other site 1116391013690 ATP binding site [chemical binding]; other site 1116391013691 Q-loop/lid; other site 1116391013692 ABC transporter signature motif; other site 1116391013693 Walker B; other site 1116391013694 D-loop; other site 1116391013695 H-loop/switch region; other site 1116391013696 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391013697 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1116391013698 Walker A/P-loop; other site 1116391013699 ATP binding site [chemical binding]; other site 1116391013700 Q-loop/lid; other site 1116391013701 ABC transporter signature motif; other site 1116391013702 Walker B; other site 1116391013703 D-loop; other site 1116391013704 H-loop/switch region; other site 1116391013705 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1116391013706 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1116391013707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391013708 dimer interface [polypeptide binding]; other site 1116391013709 conserved gate region; other site 1116391013710 putative PBP binding loops; other site 1116391013711 ABC-ATPase subunit interface; other site 1116391013712 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1116391013713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391013714 dimer interface [polypeptide binding]; other site 1116391013715 conserved gate region; other site 1116391013716 putative PBP binding loops; other site 1116391013717 ABC-ATPase subunit interface; other site 1116391013718 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1116391013719 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1116391013720 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1116391013721 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1116391013722 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391013723 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1116391013724 Coenzyme A binding pocket [chemical binding]; other site 1116391013725 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1116391013726 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1116391013727 NAD binding site [chemical binding]; other site 1116391013728 catalytic Zn binding site [ion binding]; other site 1116391013729 structural Zn binding site [ion binding]; other site 1116391013730 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1116391013731 active site 1116391013732 catalytic residues [active] 1116391013733 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1116391013734 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1116391013735 putative sugar binding sites [chemical binding]; other site 1116391013736 Q-X-W motif; other site 1116391013737 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1116391013738 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1116391013739 substrate binding site [chemical binding]; other site 1116391013740 multimerization interface [polypeptide binding]; other site 1116391013741 ATP binding site [chemical binding]; other site 1116391013742 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1116391013743 Cytochrome P450; Region: p450; cl12078 1116391013744 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391013745 MarR family; Region: MarR; pfam01047 1116391013746 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391013747 Coenzyme A binding pocket [chemical binding]; other site 1116391013748 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1116391013749 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1116391013750 SpoVR like protein; Region: SpoVR; pfam04293 1116391013751 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1116391013752 metal ion-dependent adhesion site (MIDAS); other site 1116391013753 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1116391013754 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1116391013755 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 1116391013756 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391013757 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391013758 PAS domain S-box; Region: sensory_box; TIGR00229 1116391013759 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391013760 putative active site [active] 1116391013761 heme pocket [chemical binding]; other site 1116391013762 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1116391013763 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391013764 putative active site [active] 1116391013765 heme pocket [chemical binding]; other site 1116391013766 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391013767 dimer interface [polypeptide binding]; other site 1116391013768 phosphorylation site [posttranslational modification] 1116391013769 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391013770 ATP binding site [chemical binding]; other site 1116391013771 Mg2+ binding site [ion binding]; other site 1116391013772 G-X-G motif; other site 1116391013773 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391013774 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391013775 active site 1116391013776 phosphorylation site [posttranslational modification] 1116391013777 intermolecular recognition site; other site 1116391013778 dimerization interface [polypeptide binding]; other site 1116391013779 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1116391013780 nudix motif; other site 1116391013781 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 1116391013782 putative dimer interface [polypeptide binding]; other site 1116391013783 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391013784 ligand binding site [chemical binding]; other site 1116391013785 Zn binding site [ion binding]; other site 1116391013786 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1116391013787 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1116391013788 metal ion-dependent adhesion site (MIDAS); other site 1116391013789 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1116391013790 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1116391013791 homodimer interface [polypeptide binding]; other site 1116391013792 substrate-cofactor binding pocket; other site 1116391013793 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391013794 catalytic residue [active] 1116391013795 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1116391013796 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1116391013797 Substrate-binding site [chemical binding]; other site 1116391013798 Substrate specificity [chemical binding]; other site 1116391013799 CHASE3 domain; Region: CHASE3; pfam05227 1116391013800 PAS fold; Region: PAS_4; pfam08448 1116391013801 PAS domain S-box; Region: sensory_box; TIGR00229 1116391013802 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391013803 putative active site [active] 1116391013804 heme pocket [chemical binding]; other site 1116391013805 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391013806 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391013807 metal binding site [ion binding]; metal-binding site 1116391013808 active site 1116391013809 I-site; other site 1116391013810 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1116391013811 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1116391013812 catalytic triad [active] 1116391013813 conserved cis-peptide bond; other site 1116391013814 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1116391013815 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1116391013816 peptide binding site [polypeptide binding]; other site 1116391013817 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1116391013818 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1116391013819 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1116391013820 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1116391013821 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1116391013822 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 1116391013823 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391013824 Coenzyme A binding pocket [chemical binding]; other site 1116391013825 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 1116391013826 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1116391013827 Cytochrome P450; Region: p450; cl12078 1116391013828 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1116391013829 putative transporter; Provisional; Region: PRK11660 1116391013830 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1116391013831 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1116391013832 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1116391013833 active site clefts [active] 1116391013834 zinc binding site [ion binding]; other site 1116391013835 dimer interface [polypeptide binding]; other site 1116391013836 Isochorismatase family; Region: Isochorismatase; pfam00857 1116391013837 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1116391013838 catalytic triad [active] 1116391013839 conserved cis-peptide bond; other site 1116391013840 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 1116391013841 GIY-YIG motif/motif A; other site 1116391013842 Pectic acid lyase; Region: Pec_lyase; pfam09492 1116391013843 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1116391013844 hypothetical protein; Provisional; Region: PRK13660 1116391013845 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1116391013846 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1116391013847 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1116391013848 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 1116391013849 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1116391013850 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1116391013851 putative transporter; Provisional; Region: PRK11021 1116391013852 Biofilm formation and stress response factor; Region: BsmA; pfam10014 1116391013853 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1116391013854 Ligand Binding Site [chemical binding]; other site 1116391013855 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391013856 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391013857 DNA binding residues [nucleotide binding] 1116391013858 dimerization interface [polypeptide binding]; other site 1116391013859 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1116391013860 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1116391013861 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1116391013862 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1116391013863 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1116391013864 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1116391013865 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1116391013866 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 1116391013867 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1116391013868 putative active site [active] 1116391013869 putative metal binding site [ion binding]; other site 1116391013870 multidrug efflux protein; Reviewed; Region: PRK01766 1116391013871 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1116391013872 cation binding site [ion binding]; other site 1116391013873 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 1116391013874 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391013875 Interdomain contacts; other site 1116391013876 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cd00598 1116391013877 active site 1116391013878 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391013879 non-specific DNA binding site [nucleotide binding]; other site 1116391013880 salt bridge; other site 1116391013881 sequence-specific DNA binding site [nucleotide binding]; other site 1116391013882 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1116391013883 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1116391013884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391013885 dimer interface [polypeptide binding]; other site 1116391013886 conserved gate region; other site 1116391013887 putative PBP binding loops; other site 1116391013888 ABC-ATPase subunit interface; other site 1116391013889 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1116391013890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391013891 dimer interface [polypeptide binding]; other site 1116391013892 conserved gate region; other site 1116391013893 putative PBP binding loops; other site 1116391013894 ABC-ATPase subunit interface; other site 1116391013895 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1116391013896 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 1116391013897 peptide binding site [polypeptide binding]; other site 1116391013898 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1116391013899 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391013900 Walker A/P-loop; other site 1116391013901 ATP binding site [chemical binding]; other site 1116391013902 Q-loop/lid; other site 1116391013903 ABC transporter signature motif; other site 1116391013904 Walker B; other site 1116391013905 D-loop; other site 1116391013906 H-loop/switch region; other site 1116391013907 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1116391013908 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1116391013909 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391013910 Walker A/P-loop; other site 1116391013911 ATP binding site [chemical binding]; other site 1116391013912 Q-loop/lid; other site 1116391013913 ABC transporter signature motif; other site 1116391013914 Walker B; other site 1116391013915 D-loop; other site 1116391013916 H-loop/switch region; other site 1116391013917 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1116391013918 Phytase; Region: Phytase; cl17685 1116391013919 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1116391013920 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1116391013921 NodB motif; other site 1116391013922 active site 1116391013923 catalytic site [active] 1116391013924 Cd binding site [ion binding]; other site 1116391013925 Predicted ATPase [General function prediction only]; Region: COG3910 1116391013926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391013927 Walker A/P-loop; other site 1116391013928 ATP binding site [chemical binding]; other site 1116391013929 Q-loop/lid; other site 1116391013930 ABC transporter signature motif; other site 1116391013931 Walker B; other site 1116391013932 D-loop; other site 1116391013933 H-loop/switch region; other site 1116391013934 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1116391013935 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1116391013936 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1116391013937 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391013938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391013939 dimer interface [polypeptide binding]; other site 1116391013940 phosphorylation site [posttranslational modification] 1116391013941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391013942 ATP binding site [chemical binding]; other site 1116391013943 Mg2+ binding site [ion binding]; other site 1116391013944 G-X-G motif; other site 1116391013945 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1116391013946 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 1116391013947 Walker A/P-loop; other site 1116391013948 ATP binding site [chemical binding]; other site 1116391013949 Q-loop/lid; other site 1116391013950 ABC transporter signature motif; other site 1116391013951 Walker B; other site 1116391013952 D-loop; other site 1116391013953 H-loop/switch region; other site 1116391013954 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1116391013955 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1116391013956 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1116391013957 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391013958 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391013959 active site 1116391013960 catalytic tetrad [active] 1116391013961 metal-dependent hydrolase; Provisional; Region: PRK13291 1116391013962 DinB superfamily; Region: DinB_2; pfam12867 1116391013963 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1116391013964 hydrophobic ligand binding site; other site 1116391013965 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391013966 dimerization interface [polypeptide binding]; other site 1116391013967 putative DNA binding site [nucleotide binding]; other site 1116391013968 putative Zn2+ binding site [ion binding]; other site 1116391013969 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391013970 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 1116391013971 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1116391013972 putative FMN binding site [chemical binding]; other site 1116391013973 S-layer homology domain; Region: SLH; pfam00395 1116391013974 S-layer homology domain; Region: SLH; pfam00395 1116391013975 S-layer homology domain; Region: SLH; pfam00395 1116391013976 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1116391013977 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1116391013978 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1116391013979 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1116391013980 ligand binding site [chemical binding]; other site 1116391013981 metal binding site [ion binding]; metal-binding site 1116391013982 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1116391013983 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1116391013984 DNA binding residues [nucleotide binding] 1116391013985 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1116391013986 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1116391013987 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391013988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391013989 DNA binding residues [nucleotide binding] 1116391013990 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1116391013991 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1116391013992 TAP-like protein; Region: Abhydrolase_4; pfam08386 1116391013993 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 1116391013994 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1116391013995 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1116391013996 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391013997 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391013998 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1116391013999 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1116391014000 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1116391014001 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1116391014002 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391014003 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1116391014004 ABC transporter; Region: ABC_tran_2; pfam12848 1116391014005 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 1116391014006 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1116391014007 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1116391014008 CoenzymeA binding site [chemical binding]; other site 1116391014009 subunit interaction site [polypeptide binding]; other site 1116391014010 PHB binding site; other site 1116391014011 Predicted transcriptional regulator [Transcription]; Region: COG1959 1116391014012 Transcriptional regulator; Region: Rrf2; pfam02082 1116391014013 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1116391014014 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391014015 Interdomain contacts; other site 1116391014016 Cytokine receptor motif; other site 1116391014017 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1116391014018 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391014019 TATA Binding Protein (TBP) Associated Factor 9 (TAF9) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; Region: TAF9; cl17378 1116391014020 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391014021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391014022 dimer interface [polypeptide binding]; other site 1116391014023 conserved gate region; other site 1116391014024 putative PBP binding loops; other site 1116391014025 ABC-ATPase subunit interface; other site 1116391014026 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391014027 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391014028 dimer interface [polypeptide binding]; other site 1116391014029 conserved gate region; other site 1116391014030 putative PBP binding loops; other site 1116391014031 ABC-ATPase subunit interface; other site 1116391014032 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391014033 active site 1116391014034 phosphorylation site [posttranslational modification] 1116391014035 intermolecular recognition site; other site 1116391014036 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391014037 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391014038 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391014039 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1116391014040 pentamer interface [polypeptide binding]; other site 1116391014041 dodecaamer interface [polypeptide binding]; other site 1116391014042 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 1116391014043 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391014044 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391014045 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 1116391014046 substrate binding site [chemical binding]; other site 1116391014047 catalytic residues [active] 1116391014048 S-layer homology domain; Region: SLH; pfam00395 1116391014049 S-layer homology domain; Region: SLH; pfam00395 1116391014050 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1116391014051 Cytochrome P450; Region: p450; cl12078 1116391014052 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1116391014053 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1116391014054 DNA interaction; other site 1116391014055 Metal-binding active site; metal-binding site 1116391014056 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391014057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391014058 dimer interface [polypeptide binding]; other site 1116391014059 conserved gate region; other site 1116391014060 putative PBP binding loops; other site 1116391014061 ABC-ATPase subunit interface; other site 1116391014062 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391014063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391014064 dimer interface [polypeptide binding]; other site 1116391014065 conserved gate region; other site 1116391014066 ABC-ATPase subunit interface; other site 1116391014067 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391014068 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1116391014069 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391014070 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391014071 Coat F domain; Region: Coat_F; cl17715 1116391014072 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 1116391014073 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 1116391014074 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 1116391014075 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1116391014076 homodimer interface [polypeptide binding]; other site 1116391014077 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1116391014078 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1116391014079 active site 1116391014080 homodimer interface [polypeptide binding]; other site 1116391014081 catalytic site [active] 1116391014082 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391014083 Interdomain contacts; other site 1116391014084 Cytokine receptor motif; other site 1116391014085 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1116391014086 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1116391014087 S-layer homology domain; Region: SLH; pfam00395 1116391014088 S-layer homology domain; Region: SLH; pfam00395 1116391014089 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391014090 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391014091 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391014092 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1116391014093 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1116391014094 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1116391014095 active site 1116391014096 DNA binding site [nucleotide binding] 1116391014097 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1116391014098 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1116391014099 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1116391014100 putative DNA binding site [nucleotide binding]; other site 1116391014101 putative homodimer interface [polypeptide binding]; other site 1116391014102 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391014103 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391014104 active site 1116391014105 catalytic tetrad [active] 1116391014106 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1116391014107 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1116391014108 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 1116391014109 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1116391014110 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391014111 dimerization interface [polypeptide binding]; other site 1116391014112 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391014113 dimerization interface [polypeptide binding]; other site 1116391014114 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1116391014115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391014116 dimerization interface [polypeptide binding]; other site 1116391014117 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391014118 dimerization interface [polypeptide binding]; other site 1116391014119 FOG: HAMP domain [Signal transduction mechanisms]; Region: ResE; COG2770 1116391014120 dimerization interface [polypeptide binding]; other site 1116391014121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391014122 dimerization interface [polypeptide binding]; other site 1116391014123 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391014124 dimerization interface [polypeptide binding]; other site 1116391014125 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391014126 dimerization interface [polypeptide binding]; other site 1116391014127 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1116391014128 GAF domain; Region: GAF; pfam01590 1116391014129 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391014130 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1116391014131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391014132 ATP binding site [chemical binding]; other site 1116391014133 Mg2+ binding site [ion binding]; other site 1116391014134 G-X-G motif; other site 1116391014135 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391014136 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391014137 active site 1116391014138 phosphorylation site [posttranslational modification] 1116391014139 intermolecular recognition site; other site 1116391014140 dimerization interface [polypeptide binding]; other site 1116391014141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391014142 active site 1116391014143 phosphorylation site [posttranslational modification] 1116391014144 intermolecular recognition site; other site 1116391014145 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1116391014146 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391014147 active site 1116391014148 phosphorylation site [posttranslational modification] 1116391014149 intermolecular recognition site; other site 1116391014150 dimerization interface [polypeptide binding]; other site 1116391014151 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1116391014152 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1116391014153 dimer interface [polypeptide binding]; other site 1116391014154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391014155 catalytic residue [active] 1116391014156 Cache domain; Region: Cache_1; pfam02743 1116391014157 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391014158 dimerization interface [polypeptide binding]; other site 1116391014159 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391014160 dimer interface [polypeptide binding]; other site 1116391014161 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391014162 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391014163 dimer interface [polypeptide binding]; other site 1116391014164 putative CheW interface [polypeptide binding]; other site 1116391014165 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1116391014166 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 1116391014167 active site 1116391014168 iron coordination sites [ion binding]; other site 1116391014169 substrate binding pocket [chemical binding]; other site 1116391014170 Predicted membrane protein [Function unknown]; Region: COG2323 1116391014171 Uncharacterized conserved protein (COG2071); Region: DUF2071; cl01329 1116391014172 Spore germination protein; Region: Spore_permease; cl17796 1116391014173 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391014174 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391014175 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391014176 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1116391014177 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1116391014178 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1116391014179 NAD binding site [chemical binding]; other site 1116391014180 catalytic Zn binding site [ion binding]; other site 1116391014181 structural Zn binding site [ion binding]; other site 1116391014182 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1116391014183 active site 1116391014184 DNA binding site [nucleotide binding] 1116391014185 Rhomboid family; Region: Rhomboid; pfam01694 1116391014186 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1116391014187 NlpC/P60 family; Region: NLPC_P60; pfam00877 1116391014188 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1116391014189 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1116391014190 dimer interface [polypeptide binding]; other site 1116391014191 catalytic triad [active] 1116391014192 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1116391014193 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1116391014194 peptide binding site [polypeptide binding]; other site 1116391014195 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1116391014196 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391014197 Walker A/P-loop; other site 1116391014198 ATP binding site [chemical binding]; other site 1116391014199 Q-loop/lid; other site 1116391014200 ABC transporter signature motif; other site 1116391014201 Walker B; other site 1116391014202 D-loop; other site 1116391014203 H-loop/switch region; other site 1116391014204 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1116391014205 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1116391014206 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391014207 dimer interface [polypeptide binding]; other site 1116391014208 conserved gate region; other site 1116391014209 putative PBP binding loops; other site 1116391014210 ABC-ATPase subunit interface; other site 1116391014211 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1116391014212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391014213 dimer interface [polypeptide binding]; other site 1116391014214 conserved gate region; other site 1116391014215 putative PBP binding loops; other site 1116391014216 ABC-ATPase subunit interface; other site 1116391014217 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 1116391014218 SxDxEG motif; other site 1116391014219 active site 1116391014220 metal binding site [ion binding]; metal-binding site 1116391014221 homopentamer interface [polypeptide binding]; other site 1116391014222 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391014223 Interdomain contacts; other site 1116391014224 Cytokine receptor motif; other site 1116391014225 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391014226 Interdomain contacts; other site 1116391014227 Cytokine receptor motif; other site 1116391014228 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 1116391014229 dockerin binding interface; other site 1116391014230 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 1116391014231 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1116391014232 metal binding site [ion binding]; metal-binding site 1116391014233 active site 1116391014234 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391014235 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391014236 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391014237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391014238 dimer interface [polypeptide binding]; other site 1116391014239 conserved gate region; other site 1116391014240 putative PBP binding loops; other site 1116391014241 ABC-ATPase subunit interface; other site 1116391014242 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391014243 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391014244 dimer interface [polypeptide binding]; other site 1116391014245 conserved gate region; other site 1116391014246 putative PBP binding loops; other site 1116391014247 ABC-ATPase subunit interface; other site 1116391014248 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391014249 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391014250 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1116391014251 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1116391014252 active site 1116391014253 catalytic triad [active] 1116391014254 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1116391014255 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1116391014256 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391014257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391014258 dimer interface [polypeptide binding]; other site 1116391014259 conserved gate region; other site 1116391014260 putative PBP binding loops; other site 1116391014261 ABC-ATPase subunit interface; other site 1116391014262 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391014263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391014264 dimer interface [polypeptide binding]; other site 1116391014265 conserved gate region; other site 1116391014266 putative PBP binding loops; other site 1116391014267 ABC-ATPase subunit interface; other site 1116391014268 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1116391014269 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391014270 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391014271 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1116391014272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391014273 active site 1116391014274 phosphorylation site [posttranslational modification] 1116391014275 intermolecular recognition site; other site 1116391014276 dimerization interface [polypeptide binding]; other site 1116391014277 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391014278 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391014279 HAMP domain; Region: HAMP; pfam00672 1116391014280 dimerization interface [polypeptide binding]; other site 1116391014281 Histidine kinase; Region: His_kinase; pfam06580 1116391014282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391014283 ATP binding site [chemical binding]; other site 1116391014284 Mg2+ binding site [ion binding]; other site 1116391014285 G-X-G motif; other site 1116391014286 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391014287 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1116391014288 active site 1116391014289 motif I; other site 1116391014290 motif II; other site 1116391014291 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1116391014292 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1116391014293 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1116391014294 nudix motif; other site 1116391014295 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1116391014296 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391014297 Coenzyme A binding pocket [chemical binding]; other site 1116391014298 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1116391014299 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1116391014300 E-class dimer interface [polypeptide binding]; other site 1116391014301 P-class dimer interface [polypeptide binding]; other site 1116391014302 active site 1116391014303 Cu2+ binding site [ion binding]; other site 1116391014304 Zn2+ binding site [ion binding]; other site 1116391014305 Protein of unknown function (DUF4023); Region: DUF4023; pfam13215 1116391014306 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1116391014307 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1116391014308 Predicted membrane protein [Function unknown]; Region: COG2323 1116391014309 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 1116391014310 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1116391014311 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1116391014312 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1116391014313 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1116391014314 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 1116391014315 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 1116391014316 NAD binding site [chemical binding]; other site 1116391014317 Phe binding site; other site 1116391014318 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1116391014319 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391014320 S-adenosylmethionine binding site [chemical binding]; other site 1116391014321 Predicted membrane protein [Function unknown]; Region: COG4129 1116391014322 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1116391014323 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1116391014324 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1116391014325 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1116391014326 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1116391014327 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 1116391014328 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1116391014329 dimer interface [polypeptide binding]; other site 1116391014330 active site 1116391014331 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391014332 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1116391014333 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1116391014334 active site 1116391014335 Isochorismatase family; Region: Isochorismatase; pfam00857 1116391014336 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1116391014337 catalytic triad [active] 1116391014338 conserved cis-peptide bond; other site 1116391014339 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1116391014340 Part of AAA domain; Region: AAA_19; pfam13245 1116391014341 Family description; Region: UvrD_C_2; pfam13538 1116391014342 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1116391014343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391014344 Coenzyme A binding pocket [chemical binding]; other site 1116391014345 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391014346 Coenzyme A binding pocket [chemical binding]; other site 1116391014347 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391014348 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1116391014349 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1116391014350 Coenzyme A binding pocket [chemical binding]; other site 1116391014351 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 1116391014352 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1116391014353 HlyD family secretion protein; Region: HlyD_3; pfam13437 1116391014354 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 1116391014355 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 1116391014356 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391014357 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391014358 Walker A/P-loop; other site 1116391014359 ATP binding site [chemical binding]; other site 1116391014360 Q-loop/lid; other site 1116391014361 ABC transporter signature motif; other site 1116391014362 Walker B; other site 1116391014363 D-loop; other site 1116391014364 H-loop/switch region; other site 1116391014365 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 1116391014366 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1116391014367 active site 1116391014368 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1116391014369 Putative esterase; Region: Esterase; pfam00756 1116391014370 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391014371 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391014372 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391014373 active site 1116391014374 phosphorylation site [posttranslational modification] 1116391014375 intermolecular recognition site; other site 1116391014376 dimerization interface [polypeptide binding]; other site 1116391014377 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391014378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391014379 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391014380 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1116391014381 dimerization interface [polypeptide binding]; other site 1116391014382 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391014383 Histidine kinase; Region: His_kinase; pfam06580 1116391014384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391014385 ATP binding site [chemical binding]; other site 1116391014386 Mg2+ binding site [ion binding]; other site 1116391014387 G-X-G motif; other site 1116391014388 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391014389 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391014390 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391014391 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391014392 dimer interface [polypeptide binding]; other site 1116391014393 ABC-ATPase subunit interface; other site 1116391014394 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391014395 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391014396 dimer interface [polypeptide binding]; other site 1116391014397 conserved gate region; other site 1116391014398 ABC-ATPase subunit interface; other site 1116391014399 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 1116391014400 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1116391014401 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391014402 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391014403 dimer interface [polypeptide binding]; other site 1116391014404 phosphorylation site [posttranslational modification] 1116391014405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391014406 ATP binding site [chemical binding]; other site 1116391014407 Mg2+ binding site [ion binding]; other site 1116391014408 G-X-G motif; other site 1116391014409 VanZ like family; Region: VanZ; pfam04892 1116391014410 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391014411 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391014412 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391014413 Spore germination protein; Region: Spore_permease; cl17796 1116391014414 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1116391014415 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1116391014416 putative active site [active] 1116391014417 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1116391014418 dimer interface [polypeptide binding]; other site 1116391014419 active site 1116391014420 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1116391014421 active site 1116391014422 homotetramer interface [polypeptide binding]; other site 1116391014423 homodimer interface [polypeptide binding]; other site 1116391014424 fructoselysine 3-epimerase; Provisional; Region: PRK09856 1116391014425 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1116391014426 Metal-binding active site; metal-binding site 1116391014427 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391014428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391014429 dimer interface [polypeptide binding]; other site 1116391014430 conserved gate region; other site 1116391014431 putative PBP binding loops; other site 1116391014432 ABC-ATPase subunit interface; other site 1116391014433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391014434 dimer interface [polypeptide binding]; other site 1116391014435 conserved gate region; other site 1116391014436 putative PBP binding loops; other site 1116391014437 ABC-ATPase subunit interface; other site 1116391014438 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391014439 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391014440 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1116391014441 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1116391014442 substrate binding site [chemical binding]; other site 1116391014443 ATP binding site [chemical binding]; other site 1116391014444 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1116391014445 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391014446 DNA-binding site [nucleotide binding]; DNA binding site 1116391014447 UTRA domain; Region: UTRA; pfam07702 1116391014448 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1116391014449 regulatory protein interface [polypeptide binding]; other site 1116391014450 regulatory phosphorylation site [posttranslational modification]; other site 1116391014451 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1116391014452 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1116391014453 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1116391014454 Chromate transporter; Region: Chromate_transp; pfam02417 1116391014455 Chromate transporter; Region: Chromate_transp; pfam02417 1116391014456 YmaF family; Region: YmaF; pfam12788 1116391014457 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1116391014458 YtkA-like; Region: YtkA; pfam13115 1116391014459 Family description; Region: DsbD_2; pfam13386 1116391014460 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1116391014461 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1116391014462 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1116391014463 nickel responsive regulator; Provisional; Region: PRK04460 1116391014464 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 1116391014465 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1116391014466 Predicted membrane protein [Function unknown]; Region: COG4550 1116391014467 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1116391014468 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1116391014469 Predicted permease; Region: DUF318; cl17795 1116391014470 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391014471 FeS/SAM binding site; other site 1116391014472 TRAM domain; Region: TRAM; pfam01938 1116391014473 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1116391014474 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1116391014475 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1116391014476 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1116391014477 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1116391014478 TPP-binding site [chemical binding]; other site 1116391014479 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1116391014480 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1116391014481 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1116391014482 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1116391014483 dimer interface [polypeptide binding]; other site 1116391014484 PYR/PP interface [polypeptide binding]; other site 1116391014485 TPP binding site [chemical binding]; other site 1116391014486 substrate binding site [chemical binding]; other site 1116391014487 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1116391014488 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1116391014489 active site 1116391014490 dimer interface [polypeptide binding]; other site 1116391014491 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1116391014492 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1116391014493 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391014494 putative active site [active] 1116391014495 metal binding site [ion binding]; metal-binding site 1116391014496 homodimer binding site [polypeptide binding]; other site 1116391014497 phosphodiesterase; Provisional; Region: PRK12704 1116391014498 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1116391014499 Zn2+ binding site [ion binding]; other site 1116391014500 Mg2+ binding site [ion binding]; other site 1116391014501 RecX family; Region: RecX; cl00936 1116391014502 recombinase A; Provisional; Region: recA; PRK09354 1116391014503 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1116391014504 hexamer interface [polypeptide binding]; other site 1116391014505 Walker A motif; other site 1116391014506 ATP binding site [chemical binding]; other site 1116391014507 Walker B motif; other site 1116391014508 competence damage-inducible protein A; Provisional; Region: PRK00549 1116391014509 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1116391014510 putative MPT binding site; other site 1116391014511 Competence-damaged protein; Region: CinA; pfam02464 1116391014512 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 1116391014513 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1116391014514 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1116391014515 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1116391014516 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1116391014517 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1116391014518 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1116391014519 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391014520 non-specific DNA binding site [nucleotide binding]; other site 1116391014521 salt bridge; other site 1116391014522 sequence-specific DNA binding site [nucleotide binding]; other site 1116391014523 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1116391014524 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1116391014525 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1116391014526 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1116391014527 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1116391014528 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391014529 NAD(P) binding site [chemical binding]; other site 1116391014530 active site 1116391014531 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1116391014532 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1116391014533 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1116391014534 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1116391014535 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1116391014536 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1116391014537 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1116391014538 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1116391014539 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1116391014540 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1116391014541 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1116391014542 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1116391014543 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1116391014544 YlzJ-like protein; Region: YlzJ; pfam14035 1116391014545 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1116391014546 active site 1116391014547 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1116391014548 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1116391014549 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1116391014550 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1116391014551 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1116391014552 dimer interface [polypeptide binding]; other site 1116391014553 active site 1116391014554 catalytic residue [active] 1116391014555 aspartate kinase I; Reviewed; Region: PRK08210 1116391014556 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1116391014557 nucleotide binding site [chemical binding]; other site 1116391014558 substrate binding site [chemical binding]; other site 1116391014559 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1116391014560 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1116391014561 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1116391014562 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1116391014563 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1116391014564 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1116391014565 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1116391014566 NAD binding site [chemical binding]; other site 1116391014567 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1116391014568 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1116391014569 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1116391014570 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1116391014571 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1116391014572 NodB motif; other site 1116391014573 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1116391014574 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1116391014575 RNase E interface [polypeptide binding]; other site 1116391014576 trimer interface [polypeptide binding]; other site 1116391014577 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1116391014578 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1116391014579 RNase E interface [polypeptide binding]; other site 1116391014580 trimer interface [polypeptide binding]; other site 1116391014581 active site 1116391014582 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1116391014583 putative nucleic acid binding region [nucleotide binding]; other site 1116391014584 G-X-X-G motif; other site 1116391014585 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1116391014586 RNA binding site [nucleotide binding]; other site 1116391014587 domain interface; other site 1116391014588 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1116391014589 16S/18S rRNA binding site [nucleotide binding]; other site 1116391014590 S13e-L30e interaction site [polypeptide binding]; other site 1116391014591 25S rRNA binding site [nucleotide binding]; other site 1116391014592 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1116391014593 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1116391014594 active site 1116391014595 Riboflavin kinase; Region: Flavokinase; pfam01687 1116391014596 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1116391014597 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1116391014598 RNA binding site [nucleotide binding]; other site 1116391014599 active site 1116391014600 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1116391014601 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1116391014602 DHH family; Region: DHH; pfam01368 1116391014603 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1116391014604 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1116391014605 translation initiation factor IF-2; Region: IF-2; TIGR00487 1116391014606 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1116391014607 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1116391014608 G1 box; other site 1116391014609 putative GEF interaction site [polypeptide binding]; other site 1116391014610 GTP/Mg2+ binding site [chemical binding]; other site 1116391014611 Switch I region; other site 1116391014612 G2 box; other site 1116391014613 G3 box; other site 1116391014614 Switch II region; other site 1116391014615 G4 box; other site 1116391014616 G5 box; other site 1116391014617 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1116391014618 Translation-initiation factor 2; Region: IF-2; pfam11987 1116391014619 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1116391014620 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1116391014621 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1116391014622 putative RNA binding cleft [nucleotide binding]; other site 1116391014623 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1116391014624 NusA N-terminal domain; Region: NusA_N; pfam08529 1116391014625 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1116391014626 RNA binding site [nucleotide binding]; other site 1116391014627 homodimer interface [polypeptide binding]; other site 1116391014628 NusA-like KH domain; Region: KH_5; pfam13184 1116391014629 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1116391014630 G-X-X-G motif; other site 1116391014631 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1116391014632 Sm and related proteins; Region: Sm_like; cl00259 1116391014633 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1116391014634 putative oligomer interface [polypeptide binding]; other site 1116391014635 putative RNA binding site [nucleotide binding]; other site 1116391014636 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1116391014637 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1116391014638 dimer interface [polypeptide binding]; other site 1116391014639 motif 1; other site 1116391014640 active site 1116391014641 motif 2; other site 1116391014642 motif 3; other site 1116391014643 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 1116391014644 anticodon binding site; other site 1116391014645 zinc-binding site [ion binding]; other site 1116391014646 RIP metalloprotease RseP; Region: TIGR00054 1116391014647 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1116391014648 active site 1116391014649 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1116391014650 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1116391014651 protein binding site [polypeptide binding]; other site 1116391014652 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1116391014653 putative substrate binding region [chemical binding]; other site 1116391014654 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1116391014655 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1116391014656 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1116391014657 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1116391014658 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1116391014659 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1116391014660 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 1116391014661 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1116391014662 catalytic residue [active] 1116391014663 putative FPP diphosphate binding site; other site 1116391014664 putative FPP binding hydrophobic cleft; other site 1116391014665 dimer interface [polypeptide binding]; other site 1116391014666 putative IPP diphosphate binding site; other site 1116391014667 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1116391014668 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1116391014669 hinge region; other site 1116391014670 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1116391014671 putative nucleotide binding site [chemical binding]; other site 1116391014672 uridine monophosphate binding site [chemical binding]; other site 1116391014673 homohexameric interface [polypeptide binding]; other site 1116391014674 elongation factor Ts; Reviewed; Region: tsf; PRK12332 1116391014675 UBA/TS-N domain; Region: UBA; pfam00627 1116391014676 Elongation factor TS; Region: EF_TS; pfam00889 1116391014677 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1116391014678 rRNA interaction site [nucleotide binding]; other site 1116391014679 S8 interaction site; other site 1116391014680 putative laminin-1 binding site; other site 1116391014681 YceG-like family; Region: YceG; pfam02618 1116391014682 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1116391014683 heterogeneous nuclear ribonucleoprotein R, Q family; Region: hnRNP-R-Q; TIGR01648 1116391014684 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1116391014685 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1116391014686 CheC-like family; Region: CheC; pfam04509 1116391014687 CheC-like family; Region: CheC; pfam04509 1116391014688 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1116391014689 putative CheA interaction surface; other site 1116391014690 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1116391014691 putative binding surface; other site 1116391014692 active site 1116391014693 P2 response regulator binding domain; Region: P2; pfam07194 1116391014694 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1116391014695 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1116391014696 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391014697 ATP binding site [chemical binding]; other site 1116391014698 Mg2+ binding site [ion binding]; other site 1116391014699 G-X-G motif; other site 1116391014700 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1116391014701 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1116391014702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391014703 active site 1116391014704 phosphorylation site [posttranslational modification] 1116391014705 intermolecular recognition site; other site 1116391014706 dimerization interface [polypeptide binding]; other site 1116391014707 CheB methylesterase; Region: CheB_methylest; pfam01339 1116391014708 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1116391014709 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1116391014710 P-loop; other site 1116391014711 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 1116391014712 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 1116391014713 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1116391014714 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1116391014715 FHIPEP family; Region: FHIPEP; pfam00771 1116391014716 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1116391014717 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1116391014718 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1116391014719 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1116391014720 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1116391014721 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1116391014722 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391014723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391014724 active site 1116391014725 phosphorylation site [posttranslational modification] 1116391014726 intermolecular recognition site; other site 1116391014727 dimerization interface [polypeptide binding]; other site 1116391014728 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1116391014729 CheC-like family; Region: CheC; pfam04509 1116391014730 CheC-like family; Region: CheC; pfam04509 1116391014731 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1116391014732 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1116391014733 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1116391014734 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 1116391014735 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1116391014736 Flagellar protein (FlbD); Region: FlbD; pfam06289 1116391014737 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1116391014738 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1116391014739 Class I aldolases; Region: Aldolase_Class_I; cl17187 1116391014740 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1116391014741 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 1116391014742 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1116391014743 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1116391014744 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1116391014745 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1116391014746 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1116391014747 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1116391014748 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1116391014749 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1116391014750 Walker A motif/ATP binding site; other site 1116391014751 Walker B motif; other site 1116391014752 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 1116391014753 Flagellar assembly protein FliH; Region: FliH; pfam02108 1116391014754 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1116391014755 FliG C-terminal domain; Region: FliG_C; pfam01706 1116391014756 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1116391014757 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1116391014758 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1116391014759 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1116391014760 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1116391014761 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1116391014762 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1116391014763 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1116391014764 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1116391014765 transcriptional repressor CodY; Validated; Region: PRK04158 1116391014766 CodY GAF-like domain; Region: CodY; pfam06018 1116391014767 CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222 1116391014768 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1116391014769 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1116391014770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391014771 Walker A motif; other site 1116391014772 ATP binding site [chemical binding]; other site 1116391014773 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1116391014774 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1116391014775 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1116391014776 active site 1116391014777 HslU subunit interaction site [polypeptide binding]; other site 1116391014778 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1116391014779 Glucose inhibited division protein A; Region: GIDA; pfam01134 1116391014780 DNA topoisomerase I; Validated; Region: PRK05582 1116391014781 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1116391014782 active site 1116391014783 interdomain interaction site; other site 1116391014784 putative metal-binding site [ion binding]; other site 1116391014785 nucleotide binding site [chemical binding]; other site 1116391014786 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1116391014787 domain I; other site 1116391014788 DNA binding groove [nucleotide binding] 1116391014789 phosphate binding site [ion binding]; other site 1116391014790 domain II; other site 1116391014791 domain III; other site 1116391014792 nucleotide binding site [chemical binding]; other site 1116391014793 catalytic site [active] 1116391014794 domain IV; other site 1116391014795 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1116391014796 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1116391014797 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1116391014798 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 1116391014799 DNA protecting protein DprA; Region: dprA; TIGR00732 1116391014800 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1116391014801 CoA binding domain; Region: CoA_binding; smart00881 1116391014802 CoA-ligase; Region: Ligase_CoA; pfam00549 1116391014803 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1116391014804 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1116391014805 CoA-ligase; Region: Ligase_CoA; pfam00549 1116391014806 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1116391014807 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1116391014808 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391014809 Walker A motif; other site 1116391014810 ATP binding site [chemical binding]; other site 1116391014811 Walker B motif; other site 1116391014812 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1116391014813 hypothetical protein; Reviewed; Region: PRK12497 1116391014814 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1116391014815 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1116391014816 RNA/DNA hybrid binding site [nucleotide binding]; other site 1116391014817 active site 1116391014818 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1116391014819 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1116391014820 putative active site [active] 1116391014821 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1116391014822 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1116391014823 GTP/Mg2+ binding site [chemical binding]; other site 1116391014824 G4 box; other site 1116391014825 G5 box; other site 1116391014826 G1 box; other site 1116391014827 Switch I region; other site 1116391014828 G2 box; other site 1116391014829 G3 box; other site 1116391014830 Switch II region; other site 1116391014831 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1116391014832 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1116391014833 Catalytic site [active] 1116391014834 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 1116391014835 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1116391014836 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 1116391014837 S-layer homology domain; Region: SLH; pfam00395 1116391014838 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1116391014839 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1116391014840 RimM N-terminal domain; Region: RimM; pfam01782 1116391014841 PRC-barrel domain; Region: PRC; pfam05239 1116391014842 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1116391014843 hypothetical protein; Provisional; Region: PRK00468 1116391014844 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1116391014845 signal recognition particle protein; Provisional; Region: PRK10867 1116391014846 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1116391014847 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1116391014848 P loop; other site 1116391014849 GTP binding site [chemical binding]; other site 1116391014850 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1116391014851 putative DNA-binding protein; Validated; Region: PRK00118 1116391014852 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1116391014853 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1116391014854 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1116391014855 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1116391014856 P loop; other site 1116391014857 GTP binding site [chemical binding]; other site 1116391014858 ribonuclease III; Reviewed; Region: rnc; PRK00102 1116391014859 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1116391014860 dimerization interface [polypeptide binding]; other site 1116391014861 active site 1116391014862 metal binding site [ion binding]; metal-binding site 1116391014863 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1116391014864 dsRNA binding site [nucleotide binding]; other site 1116391014865 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1116391014866 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1116391014867 dimer interface [polypeptide binding]; other site 1116391014868 active site 1116391014869 acyl carrier protein; Provisional; Region: acpP; PRK00982 1116391014870 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1116391014871 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1116391014872 NAD(P) binding site [chemical binding]; other site 1116391014873 homotetramer interface [polypeptide binding]; other site 1116391014874 homodimer interface [polypeptide binding]; other site 1116391014875 active site 1116391014876 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1116391014877 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1116391014878 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1116391014879 dimer interface [polypeptide binding]; other site 1116391014880 active site 1116391014881 CoA binding pocket [chemical binding]; other site 1116391014882 putative phosphate acyltransferase; Provisional; Region: PRK05331 1116391014883 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1116391014884 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1116391014885 active site 2 [active] 1116391014886 active site 1 [active] 1116391014887 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1116391014888 hypothetical protein; Provisional; Region: PRK13670 1116391014889 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1116391014890 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1116391014891 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1116391014892 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1116391014893 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1116391014894 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1116391014895 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1116391014896 active site 1116391014897 (T/H)XGH motif; other site 1116391014898 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1116391014899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391014900 S-adenosylmethionine binding site [chemical binding]; other site 1116391014901 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1116391014902 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1116391014903 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1116391014904 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1116391014905 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1116391014906 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1116391014907 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 1116391014908 active site 1116391014909 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1116391014910 RDD family; Region: RDD; pfam06271 1116391014911 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1116391014912 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391014913 putative metal binding site [ion binding]; other site 1116391014914 Predicted membrane protein [Function unknown]; Region: COG3766 1116391014915 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1116391014916 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 1116391014917 Glucuronate isomerase; Region: UxaC; pfam02614 1116391014918 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1116391014919 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1116391014920 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1116391014921 Right handed beta helix region; Region: Beta_helix; pfam13229 1116391014922 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1116391014923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391014924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391014925 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1116391014926 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1116391014927 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1116391014928 generic binding surface II; other site 1116391014929 ssDNA binding site; other site 1116391014930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1116391014931 ATP binding site [chemical binding]; other site 1116391014932 putative Mg++ binding site [ion binding]; other site 1116391014933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1116391014934 nucleotide binding region [chemical binding]; other site 1116391014935 ATP-binding site [chemical binding]; other site 1116391014936 EDD domain protein, DegV family; Region: DegV; TIGR00762 1116391014937 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1116391014938 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1116391014939 DAK2 domain; Region: Dak2; pfam02734 1116391014940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1116391014941 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1116391014942 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1116391014943 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1116391014944 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1116391014945 substrate binding site [chemical binding]; other site 1116391014946 hexamer interface [polypeptide binding]; other site 1116391014947 metal binding site [ion binding]; metal-binding site 1116391014948 GTPase RsgA; Reviewed; Region: PRK00098 1116391014949 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1116391014950 RNA binding site [nucleotide binding]; other site 1116391014951 homodimer interface [polypeptide binding]; other site 1116391014952 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1116391014953 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1116391014954 GTP/Mg2+ binding site [chemical binding]; other site 1116391014955 G4 box; other site 1116391014956 G5 box; other site 1116391014957 G1 box; other site 1116391014958 Switch I region; other site 1116391014959 G2 box; other site 1116391014960 G3 box; other site 1116391014961 Switch II region; other site 1116391014962 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1116391014963 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1116391014964 active site 1116391014965 ATP binding site [chemical binding]; other site 1116391014966 substrate binding site [chemical binding]; other site 1116391014967 activation loop (A-loop); other site 1116391014968 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1116391014969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1116391014970 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1116391014971 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1116391014972 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1116391014973 active site 1116391014974 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1116391014975 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391014976 FeS/SAM binding site; other site 1116391014977 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1116391014978 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 1116391014979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391014980 S-adenosylmethionine binding site [chemical binding]; other site 1116391014981 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1116391014982 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1116391014983 putative active site [active] 1116391014984 substrate binding site [chemical binding]; other site 1116391014985 putative cosubstrate binding site; other site 1116391014986 catalytic site [active] 1116391014987 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1116391014988 substrate binding site [chemical binding]; other site 1116391014989 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1116391014990 active site 1116391014991 catalytic residues [active] 1116391014992 metal binding site [ion binding]; metal-binding site 1116391014993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1116391014994 primosomal protein N' Region: priA; TIGR00595 1116391014995 ATP binding site [chemical binding]; other site 1116391014996 putative Mg++ binding site [ion binding]; other site 1116391014997 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1116391014998 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1116391014999 Flavoprotein; Region: Flavoprotein; pfam02441 1116391015000 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1116391015001 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1116391015002 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1116391015003 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1116391015004 catalytic site [active] 1116391015005 G-X2-G-X-G-K; other site 1116391015006 hypothetical protein; Provisional; Region: PRK04323 1116391015007 hypothetical protein; Provisional; Region: PRK11820 1116391015008 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1116391015009 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1116391015010 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1116391015011 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1116391015012 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1116391015013 FAD binding site [chemical binding]; other site 1116391015014 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1116391015015 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1116391015016 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1116391015017 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1116391015018 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1116391015019 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1116391015020 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1116391015021 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391015022 motif II; other site 1116391015023 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1116391015024 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1116391015025 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1116391015026 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1116391015027 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1116391015028 DNA binding residues [nucleotide binding] 1116391015029 B12 binding domain; Region: B12-binding_2; pfam02607 1116391015030 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1116391015031 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1116391015032 CheB methylesterase; Region: CheB_methylest; pfam01339 1116391015033 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1116391015034 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1116391015035 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1116391015036 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 1116391015037 PAS domain; Region: PAS_10; pfam13596 1116391015038 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1116391015039 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391015040 putative active site [active] 1116391015041 heme pocket [chemical binding]; other site 1116391015042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391015043 dimer interface [polypeptide binding]; other site 1116391015044 phosphorylation site [posttranslational modification] 1116391015045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391015046 ATP binding site [chemical binding]; other site 1116391015047 Mg2+ binding site [ion binding]; other site 1116391015048 G-X-G motif; other site 1116391015049 B12 binding domain; Region: B12-binding_2; pfam02607 1116391015050 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 1116391015051 B12 binding site [chemical binding]; other site 1116391015052 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1116391015053 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1116391015054 active site 1116391015055 tetramer interface; other site 1116391015056 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1116391015057 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1116391015058 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1116391015059 putative dimerization interface [polypeptide binding]; other site 1116391015060 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 1116391015061 L-asparaginase II; Region: Asparaginase_II; pfam06089 1116391015062 Protein of unknown function (DUF964); Region: DUF964; cl01483 1116391015063 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1116391015064 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1116391015065 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1116391015066 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1116391015067 ATP binding site [chemical binding]; other site 1116391015068 putative Mg++ binding site [ion binding]; other site 1116391015069 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1116391015070 nucleotide binding region [chemical binding]; other site 1116391015071 ATP-binding site [chemical binding]; other site 1116391015072 Staphylococcal nuclease homologues; Region: SNc; smart00318 1116391015073 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 1116391015074 Catalytic site; other site 1116391015075 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1116391015076 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1116391015077 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1116391015078 active site 1116391015079 HIGH motif; other site 1116391015080 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1116391015081 tRNA binding surface [nucleotide binding]; other site 1116391015082 anticodon binding site; other site 1116391015083 FOG: CBS domain [General function prediction only]; Region: COG0517 1116391015084 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1116391015085 YugN-like family; Region: YugN; pfam08868 1116391015086 cell division protein FtsW; Region: ftsW; TIGR02614 1116391015087 Asp23 family; Region: Asp23; pfam03780 1116391015088 calcium/proton exchanger (cax); Region: cax; TIGR00378 1116391015089 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1116391015090 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1116391015091 hypothetical protein; Provisional; Region: PRK13666 1116391015092 PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381 1116391015093 regulatory protein interface [polypeptide binding]; other site 1116391015094 regulatory phosphorylation site [posttranslational modification]; other site 1116391015095 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1116391015096 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1116391015097 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1116391015098 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1116391015099 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1116391015100 RNA binding surface [nucleotide binding]; other site 1116391015101 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1116391015102 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1116391015103 active site 1116391015104 HIGH motif; other site 1116391015105 dimer interface [polypeptide binding]; other site 1116391015106 KMSKS motif; other site 1116391015107 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1116391015108 RNA binding surface [nucleotide binding]; other site 1116391015109 acetyl-CoA synthetase; Provisional; Region: PRK04319 1116391015110 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1116391015111 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 1116391015112 active site 1116391015113 acyl-activating enzyme (AAE) consensus motif; other site 1116391015114 putative CoA binding site [chemical binding]; other site 1116391015115 AMP binding site [chemical binding]; other site 1116391015116 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 1116391015117 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1116391015118 active site 1116391015119 Zn binding site [ion binding]; other site 1116391015120 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1116391015121 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1116391015122 motif 1; other site 1116391015123 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1116391015124 active site 1116391015125 motif 2; other site 1116391015126 motif 3; other site 1116391015127 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1116391015128 anticodon binding site; other site 1116391015129 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1116391015130 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1116391015131 catabolite control protein A; Region: ccpA; TIGR01481 1116391015132 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391015133 DNA binding site [nucleotide binding] 1116391015134 domain linker motif; other site 1116391015135 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1116391015136 dimerization interface [polypeptide binding]; other site 1116391015137 effector binding site; other site 1116391015138 Predicted integral membrane protein [Function unknown]; Region: COG5652 1116391015139 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1116391015140 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1116391015141 proposed catalytic triad [active] 1116391015142 conserved cys residue [active] 1116391015143 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1116391015144 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1116391015145 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1116391015146 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1116391015147 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1116391015148 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1116391015149 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1116391015150 active site turn [active] 1116391015151 phosphorylation site [posttranslational modification] 1116391015152 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1116391015153 HPr interaction site; other site 1116391015154 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1116391015155 active site 1116391015156 phosphorylation site [posttranslational modification] 1116391015157 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1116391015158 thiamine phosphate binding site [chemical binding]; other site 1116391015159 active site 1116391015160 pyrophosphate binding site [ion binding]; other site 1116391015161 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1116391015162 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1116391015163 putative active site [active] 1116391015164 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1116391015165 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1116391015166 hinge; other site 1116391015167 active site 1116391015168 CrcB-like protein; Region: CRCB; cl09114 1116391015169 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1116391015170 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1116391015171 active site residue [active] 1116391015172 shikimate kinase; Reviewed; Region: aroK; PRK00131 1116391015173 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1116391015174 ADP binding site [chemical binding]; other site 1116391015175 magnesium binding site [ion binding]; other site 1116391015176 putative shikimate binding site; other site 1116391015177 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1116391015178 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1116391015179 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1116391015180 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1116391015181 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391015182 NAD(P) binding site [chemical binding]; other site 1116391015183 active site 1116391015184 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1116391015185 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1116391015186 N- and C-terminal domain interface [polypeptide binding]; other site 1116391015187 active site 1116391015188 catalytic site [active] 1116391015189 metal binding site [ion binding]; metal-binding site 1116391015190 carbohydrate binding site [chemical binding]; other site 1116391015191 ATP binding site [chemical binding]; other site 1116391015192 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1116391015193 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391015194 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391015195 DNA binding site [nucleotide binding] 1116391015196 domain linker motif; other site 1116391015197 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1116391015198 dimerization interface [polypeptide binding]; other site 1116391015199 ligand binding site [chemical binding]; other site 1116391015200 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391015201 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1116391015202 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1116391015203 active site 1116391015204 catalytic triad [active] 1116391015205 oxyanion hole [active] 1116391015206 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1116391015207 metal binding site [ion binding]; metal-binding site 1116391015208 active site 1116391015209 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391015210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391015211 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391015212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391015213 dimer interface [polypeptide binding]; other site 1116391015214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391015215 ABC-ATPase subunit interface; other site 1116391015216 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391015217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391015218 dimer interface [polypeptide binding]; other site 1116391015219 conserved gate region; other site 1116391015220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391015221 ABC-ATPase subunit interface; other site 1116391015222 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391015223 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391015224 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391015225 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391015226 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1116391015227 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1116391015228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391015229 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391015230 putative substrate translocation pore; other site 1116391015231 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1116391015232 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1116391015233 homodimer interface [polypeptide binding]; other site 1116391015234 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391015235 catalytic residue [active] 1116391015236 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1116391015237 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 1116391015238 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391015239 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391015240 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1116391015241 active site 1116391015242 motif I; other site 1116391015243 motif II; other site 1116391015244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391015245 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 1116391015246 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 1116391015247 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391015248 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1116391015249 Arginase family; Region: Arginase; cd09989 1116391015250 active site 1116391015251 Mn binding site [ion binding]; other site 1116391015252 oligomer interface [polypeptide binding]; other site 1116391015253 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1116391015254 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1116391015255 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1116391015256 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391015257 dimerization interface [polypeptide binding]; other site 1116391015258 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391015259 dimer interface [polypeptide binding]; other site 1116391015260 putative CheW interface [polypeptide binding]; other site 1116391015261 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391015262 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391015263 metal binding site [ion binding]; metal-binding site 1116391015264 active site 1116391015265 I-site; other site 1116391015266 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391015267 dimer interface [polypeptide binding]; other site 1116391015268 phosphorylation site [posttranslational modification] 1116391015269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391015270 ATP binding site [chemical binding]; other site 1116391015271 Mg2+ binding site [ion binding]; other site 1116391015272 G-X-G motif; other site 1116391015273 Divergent PAP2 family; Region: DUF212; pfam02681 1116391015274 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1116391015275 GTP binding site; other site 1116391015276 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1116391015277 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1116391015278 ligand binding site [chemical binding]; other site 1116391015279 flexible hinge region; other site 1116391015280 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1116391015281 putative switch regulator; other site 1116391015282 non-specific DNA interactions [nucleotide binding]; other site 1116391015283 DNA binding site [nucleotide binding] 1116391015284 sequence specific DNA binding site [nucleotide binding]; other site 1116391015285 putative cAMP binding site [chemical binding]; other site 1116391015286 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 1116391015287 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1116391015288 Phosphotransferase enzyme family; Region: APH; pfam01636 1116391015289 active site 1116391015290 substrate binding site [chemical binding]; other site 1116391015291 ATP binding site [chemical binding]; other site 1116391015292 PilZ domain; Region: PilZ; pfam07238 1116391015293 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1116391015294 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1116391015295 active site 1116391015296 DNA binding site [nucleotide binding] 1116391015297 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 1116391015298 DNA binding site [nucleotide binding] 1116391015299 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1116391015300 putative deacylase active site [active] 1116391015301 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 1116391015302 WYL domain; Region: WYL; cl14852 1116391015303 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391015304 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1116391015305 active site 1116391015306 metal binding site [ion binding]; metal-binding site 1116391015307 Protein of unknown function (DUF2772); Region: DUF2772; pfam10970 1116391015308 Spore germination protein GerPC; Region: GerPC; pfam10737 1116391015309 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 1116391015310 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1116391015311 endonuclease subunit; Provisional; Region: 47; PHA02546 1116391015312 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 1116391015313 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1116391015314 tetramer interfaces [polypeptide binding]; other site 1116391015315 binuclear metal-binding site [ion binding]; other site 1116391015316 hypothetical protein; Provisional; Region: PRK13679 1116391015317 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1116391015318 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1116391015319 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1116391015320 HlyD family secretion protein; Region: HlyD_3; pfam13437 1116391015321 Predicted transcriptional regulators [Transcription]; Region: COG1510 1116391015322 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391015323 putative DNA binding site [nucleotide binding]; other site 1116391015324 putative Zn2+ binding site [ion binding]; other site 1116391015325 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 1116391015326 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391015327 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391015328 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1116391015329 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1116391015330 Walker A/P-loop; other site 1116391015331 ATP binding site [chemical binding]; other site 1116391015332 Q-loop/lid; other site 1116391015333 ABC transporter signature motif; other site 1116391015334 Walker B; other site 1116391015335 D-loop; other site 1116391015336 H-loop/switch region; other site 1116391015337 FtsX-like permease family; Region: FtsX; pfam02687 1116391015338 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1116391015339 HlyD family secretion protein; Region: HlyD_3; pfam13437 1116391015340 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1116391015341 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1116391015342 Walker A/P-loop; other site 1116391015343 ATP binding site [chemical binding]; other site 1116391015344 Q-loop/lid; other site 1116391015345 ABC transporter signature motif; other site 1116391015346 Walker B; other site 1116391015347 D-loop; other site 1116391015348 H-loop/switch region; other site 1116391015349 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391015350 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391015351 dimer interface [polypeptide binding]; other site 1116391015352 putative CheW interface [polypeptide binding]; other site 1116391015353 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1116391015354 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1116391015355 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1116391015356 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1116391015357 putative dimer interface [polypeptide binding]; other site 1116391015358 putative anticodon binding site; other site 1116391015359 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1116391015360 homodimer interface [polypeptide binding]; other site 1116391015361 motif 1; other site 1116391015362 motif 2; other site 1116391015363 active site 1116391015364 motif 3; other site 1116391015365 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1116391015366 propionate/acetate kinase; Provisional; Region: PRK12379 1116391015367 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1116391015368 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1116391015369 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1116391015370 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1116391015371 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1116391015372 substrate binding site [chemical binding]; other site 1116391015373 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1116391015374 substrate binding site [chemical binding]; other site 1116391015375 ligand binding site [chemical binding]; other site 1116391015376 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391015377 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391015378 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391015379 dimerization interface [polypeptide binding]; other site 1116391015380 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1116391015381 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1116391015382 putative active site [active] 1116391015383 catalytic triad [active] 1116391015384 putative dimer interface [polypeptide binding]; other site 1116391015385 transaminase; Reviewed; Region: PRK08068 1116391015386 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391015387 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391015388 homodimer interface [polypeptide binding]; other site 1116391015389 catalytic residue [active] 1116391015390 gamma-glutamyl kinase; Provisional; Region: PRK05429 1116391015391 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1116391015392 nucleotide binding site [chemical binding]; other site 1116391015393 homotetrameric interface [polypeptide binding]; other site 1116391015394 putative phosphate binding site [ion binding]; other site 1116391015395 putative allosteric binding site; other site 1116391015396 PUA domain; Region: PUA; pfam01472 1116391015397 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1116391015398 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1116391015399 putative catalytic cysteine [active] 1116391015400 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391015401 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1116391015402 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1116391015403 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1116391015404 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1116391015405 dimer interface [polypeptide binding]; other site 1116391015406 active site 1116391015407 catalytic residue [active] 1116391015408 metal binding site [ion binding]; metal-binding site 1116391015409 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1116391015410 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1116391015411 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1116391015412 intersubunit interface [polypeptide binding]; other site 1116391015413 active site 1116391015414 Zn2+ binding site [ion binding]; other site 1116391015415 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1116391015416 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1116391015417 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1116391015418 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1116391015419 Walker A/P-loop; other site 1116391015420 ATP binding site [chemical binding]; other site 1116391015421 Q-loop/lid; other site 1116391015422 ABC transporter signature motif; other site 1116391015423 Walker B; other site 1116391015424 D-loop; other site 1116391015425 H-loop/switch region; other site 1116391015426 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1116391015427 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391015428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391015429 DNA binding residues [nucleotide binding] 1116391015430 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1116391015431 active site 1116391015432 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1116391015433 active site 1116391015434 dimer interface [polypeptide binding]; other site 1116391015435 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1116391015436 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1116391015437 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1116391015438 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1116391015439 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1116391015440 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1116391015441 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1116391015442 IMP binding site; other site 1116391015443 dimer interface [polypeptide binding]; other site 1116391015444 interdomain contacts; other site 1116391015445 partial ornithine binding site; other site 1116391015446 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1116391015447 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1116391015448 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1116391015449 catalytic site [active] 1116391015450 subunit interface [polypeptide binding]; other site 1116391015451 dihydroorotase; Validated; Region: pyrC; PRK09357 1116391015452 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1116391015453 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1116391015454 active site 1116391015455 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1116391015456 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1116391015457 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1116391015458 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1116391015459 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1116391015460 active site 1116391015461 Domain of unknown function (DUF4157); Region: DUF4157; pfam13699 1116391015462 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1116391015463 amidase catalytic site [active] 1116391015464 Zn binding residues [ion binding]; other site 1116391015465 substrate binding site [chemical binding]; other site 1116391015466 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1116391015467 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1116391015468 active site 1116391015469 catalytic triad [active] 1116391015470 oxyanion hole [active] 1116391015471 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391015472 Interdomain contacts; other site 1116391015473 Cytokine receptor motif; other site 1116391015474 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391015475 Interdomain contacts; other site 1116391015476 Cytokine receptor motif; other site 1116391015477 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1116391015478 Protein of unknown function (DUF2612); Region: DUF2612; pfam11041 1116391015479 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1116391015480 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391015481 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1116391015482 Protein of unknown function (DUF3383); Region: DUF3383; pfam11863 1116391015483 Protein of unknown function (DUF4054); Region: DUF4054; pfam13262 1116391015484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4834 1116391015485 Uncharacterized protein conserved in bacteria (DUF2184); Region: DUF2184; pfam09950 1116391015486 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3566 1116391015487 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 1116391015488 SEC-C motif; Region: SEC-C; pfam02810 1116391015489 Uncharacterized protein, homolog of phage Mu protein gp30 [Function unknown]; Region: COG2369 1116391015490 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1116391015491 VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of...; Region: VIP2; cl00173 1116391015492 active site 1116391015493 conformational flexibility of ligand binding pocket; other site 1116391015494 ADP-ribosylating toxin turn-turn motif; other site 1116391015495 phage-related protein, HI1409 family; Region: phge_rel_HI1409; TIGR01555 1116391015496 Protein of unknown function (DUF1073); Region: DUF1073; pfam06381 1116391015497 Phage terminase large subunit; Region: Terminase_3; cl12054 1116391015498 Terminase-like family; Region: Terminase_6; pfam03237 1116391015499 Terminase small subunit; Region: Terminase_2; pfam03592 1116391015500 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 1116391015501 phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636 1116391015502 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 1116391015503 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 1116391015504 active site 1116391015505 putative DNA-binding cleft [nucleotide binding]; other site 1116391015506 dimer interface [polypeptide binding]; other site 1116391015507 replicative DNA helicase; Region: DnaB; TIGR00665 1116391015508 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1116391015509 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1116391015510 Walker A motif; other site 1116391015511 ATP binding site [chemical binding]; other site 1116391015512 Walker B motif; other site 1116391015513 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 1116391015514 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 1116391015515 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1116391015516 active site 1116391015517 catalytic site [active] 1116391015518 substrate binding site [chemical binding]; other site 1116391015519 RecT family; Region: RecT; cl04285 1116391015520 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1116391015521 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1116391015522 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1116391015523 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 1116391015524 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1116391015525 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391015526 non-specific DNA binding site [nucleotide binding]; other site 1116391015527 salt bridge; other site 1116391015528 sequence-specific DNA binding site [nucleotide binding]; other site 1116391015529 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1116391015530 sequence-specific DNA binding site [nucleotide binding]; other site 1116391015531 salt bridge; other site 1116391015532 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1116391015533 Int/Topo IB signature motif; other site 1116391015534 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1116391015535 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1116391015536 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1116391015537 putative trimer interface [polypeptide binding]; other site 1116391015538 putative CoA binding site [chemical binding]; other site 1116391015539 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1116391015540 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1116391015541 metal binding site [ion binding]; metal-binding site 1116391015542 putative dimer interface [polypeptide binding]; other site 1116391015543 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1116391015544 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1116391015545 RNA binding surface [nucleotide binding]; other site 1116391015546 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1116391015547 active site 1116391015548 lipoprotein signal peptidase; Provisional; Region: PRK14787 1116391015549 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 1116391015550 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1116391015551 DivIVA protein; Region: DivIVA; pfam05103 1116391015552 DivIVA domain; Region: DivI1A_domain; TIGR03544 1116391015553 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1116391015554 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1116391015555 RNA binding surface [nucleotide binding]; other site 1116391015556 Protein of unknown function (DUF552); Region: DUF552; cl00775 1116391015557 YGGT family; Region: YGGT; pfam02325 1116391015558 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1116391015559 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1116391015560 catalytic residue [active] 1116391015561 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1116391015562 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1116391015563 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1116391015564 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391015565 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1116391015566 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391015567 DNA binding residues [nucleotide binding] 1116391015568 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1116391015569 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391015570 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391015571 DNA binding residues [nucleotide binding] 1116391015572 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1116391015573 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1116391015574 cell division protein FtsZ; Validated; Region: PRK09330 1116391015575 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1116391015576 nucleotide binding site [chemical binding]; other site 1116391015577 SulA interaction site; other site 1116391015578 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1116391015579 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1116391015580 nucleotide binding site [chemical binding]; other site 1116391015581 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1116391015582 Cell division protein FtsA; Region: FtsA; pfam14450 1116391015583 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1116391015584 Cell division protein FtsQ; Region: FtsQ; pfam03799 1116391015585 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1116391015586 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1116391015587 hinge; other site 1116391015588 active site 1116391015589 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1116391015590 FAD binding domain; Region: FAD_binding_4; pfam01565 1116391015591 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1116391015592 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1116391015593 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1116391015594 active site 1116391015595 homodimer interface [polypeptide binding]; other site 1116391015596 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1116391015597 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1116391015598 TrkA-N domain; Region: TrkA_N; pfam02254 1116391015599 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1116391015600 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1116391015601 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1116391015602 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1116391015603 Mg++ binding site [ion binding]; other site 1116391015604 putative catalytic motif [active] 1116391015605 putative substrate binding site [chemical binding]; other site 1116391015606 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1116391015607 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1116391015608 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1116391015609 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1116391015610 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 1116391015611 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1116391015612 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1116391015613 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1116391015614 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1116391015615 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1116391015616 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1116391015617 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1116391015618 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1116391015619 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1116391015620 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1116391015621 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 1116391015622 Cell division protein FtsL; Region: FtsL; cl11433 1116391015623 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1116391015624 MraW methylase family; Region: Methyltransf_5; pfam01795 1116391015625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1116391015626 MraZ protein; Region: MraZ; pfam02381 1116391015627 MraZ protein; Region: MraZ; pfam02381 1116391015628 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 1116391015629 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1116391015630 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1116391015631 homotetramer interface [polypeptide binding]; other site 1116391015632 ligand binding site [chemical binding]; other site 1116391015633 catalytic site [active] 1116391015634 NAD binding site [chemical binding]; other site 1116391015635 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1116391015636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1116391015637 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 1116391015638 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1116391015639 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391015640 Walker A/P-loop; other site 1116391015641 ATP binding site [chemical binding]; other site 1116391015642 Q-loop/lid; other site 1116391015643 ABC transporter signature motif; other site 1116391015644 Walker B; other site 1116391015645 D-loop; other site 1116391015646 H-loop/switch region; other site 1116391015647 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1116391015648 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1116391015649 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391015650 Walker A/P-loop; other site 1116391015651 ATP binding site [chemical binding]; other site 1116391015652 Q-loop/lid; other site 1116391015653 ABC transporter signature motif; other site 1116391015654 Walker B; other site 1116391015655 D-loop; other site 1116391015656 H-loop/switch region; other site 1116391015657 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1116391015658 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1116391015659 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1116391015660 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391015661 dimer interface [polypeptide binding]; other site 1116391015662 conserved gate region; other site 1116391015663 putative PBP binding loops; other site 1116391015664 ABC-ATPase subunit interface; other site 1116391015665 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1116391015666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391015667 dimer interface [polypeptide binding]; other site 1116391015668 conserved gate region; other site 1116391015669 putative PBP binding loops; other site 1116391015670 ABC-ATPase subunit interface; other site 1116391015671 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1116391015672 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1116391015673 peptide binding site [polypeptide binding]; other site 1116391015674 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1116391015675 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1116391015676 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1116391015677 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1116391015678 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1116391015679 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 1116391015680 Uncharacterized conserved protein [Function unknown]; Region: COG1565 1116391015681 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1116391015682 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1116391015683 putative active site [active] 1116391015684 PhoH-like protein; Region: PhoH; pfam02562 1116391015685 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1116391015686 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1116391015687 YlaH-like protein; Region: YlaH; pfam14036 1116391015688 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1116391015689 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1116391015690 G1 box; other site 1116391015691 putative GEF interaction site [polypeptide binding]; other site 1116391015692 GTP/Mg2+ binding site [chemical binding]; other site 1116391015693 Switch I region; other site 1116391015694 G2 box; other site 1116391015695 G3 box; other site 1116391015696 Switch II region; other site 1116391015697 G4 box; other site 1116391015698 G5 box; other site 1116391015699 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1116391015700 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1116391015701 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1116391015702 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1116391015703 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1116391015704 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1116391015705 Ligand Binding Site [chemical binding]; other site 1116391015706 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1116391015707 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1116391015708 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1116391015709 catalytic residue [active] 1116391015710 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1116391015711 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1116391015712 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1116391015713 catalytic residue [active] 1116391015714 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1116391015715 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1116391015716 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1116391015717 active site 1116391015718 catalytic triad [active] 1116391015719 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1116391015720 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1116391015721 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1116391015722 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1116391015723 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1116391015724 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1116391015725 Family of unknown function (DUF633); Region: DUF633; pfam04816 1116391015726 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1116391015727 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1116391015728 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1116391015729 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391015730 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1116391015731 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391015732 DNA binding residues [nucleotide binding] 1116391015733 DNA primase; Validated; Region: dnaG; PRK05667 1116391015734 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1116391015735 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1116391015736 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1116391015737 active site 1116391015738 metal binding site [ion binding]; metal-binding site 1116391015739 interdomain interaction site; other site 1116391015740 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1116391015741 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 1116391015742 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 1116391015743 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1116391015744 Recombination protein O N terminal; Region: RecO_N; pfam11967 1116391015745 Recombination protein O C terminal; Region: RecO_C; pfam02565 1116391015746 YqzL-like protein; Region: YqzL; pfam14006 1116391015747 GTPase Era; Reviewed; Region: era; PRK00089 1116391015748 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1116391015749 G1 box; other site 1116391015750 GTP/Mg2+ binding site [chemical binding]; other site 1116391015751 Switch I region; other site 1116391015752 G2 box; other site 1116391015753 Switch II region; other site 1116391015754 G3 box; other site 1116391015755 G4 box; other site 1116391015756 G5 box; other site 1116391015757 KH domain; Region: KH_2; pfam07650 1116391015758 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1116391015759 active site 1116391015760 catalytic motif [active] 1116391015761 Zn binding site [ion binding]; other site 1116391015762 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1116391015763 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1116391015764 active site 1116391015765 metal-binding heat shock protein; Provisional; Region: PRK00016 1116391015766 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1116391015767 PhoH-like protein; Region: PhoH; pfam02562 1116391015768 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1116391015769 YabP family; Region: YabP; cl06766 1116391015770 hypothetical protein; Provisional; Region: PRK13665 1116391015771 Yqey-like protein; Region: YqeY; pfam09424 1116391015772 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1116391015773 nucleotide binding site/active site [active] 1116391015774 HIT family signature motif; other site 1116391015775 catalytic residue [active] 1116391015776 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391015777 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391015778 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 1116391015779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1116391015780 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1116391015781 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391015782 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1116391015783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391015784 ABC transporter signature motif; other site 1116391015785 Walker B; other site 1116391015786 D-loop; other site 1116391015787 H-loop/switch region; other site 1116391015788 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1116391015789 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1116391015790 Walker A/P-loop; other site 1116391015791 ATP binding site [chemical binding]; other site 1116391015792 Q-loop/lid; other site 1116391015793 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1116391015794 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391015795 active site 1116391015796 metal binding site [ion binding]; metal-binding site 1116391015797 DNA binding site [nucleotide binding] 1116391015798 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1116391015799 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1116391015800 Part of AAA domain; Region: AAA_19; pfam13245 1116391015801 Family description; Region: UvrD_C_2; pfam13538 1116391015802 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1116391015803 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1116391015804 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1116391015805 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1116391015806 dimer interface [polypeptide binding]; other site 1116391015807 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1116391015808 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1116391015809 putative RNA binding site [nucleotide binding]; other site 1116391015810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391015811 S-adenosylmethionine binding site [chemical binding]; other site 1116391015812 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1116391015813 active site 1116391015814 Ap6A binding site [chemical binding]; other site 1116391015815 nudix motif; other site 1116391015816 metal binding site [ion binding]; metal-binding site 1116391015817 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1116391015818 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1116391015819 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391015820 FeS/SAM binding site; other site 1116391015821 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1116391015822 RNA methyltransferase, RsmE family; Region: TIGR00046 1116391015823 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1116391015824 Peptidase family M50; Region: Peptidase_M50; pfam02163 1116391015825 active site 1116391015826 putative substrate binding region [chemical binding]; other site 1116391015827 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1116391015828 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391015829 S-adenosylmethionine binding site [chemical binding]; other site 1116391015830 YfhD-like protein; Region: YfhD; pfam14151 1116391015831 chaperone protein DnaJ; Provisional; Region: PRK14280 1116391015832 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1116391015833 HSP70 interaction site [polypeptide binding]; other site 1116391015834 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1116391015835 substrate binding site [polypeptide binding]; other site 1116391015836 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1116391015837 Zn binding sites [ion binding]; other site 1116391015838 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1116391015839 dimer interface [polypeptide binding]; other site 1116391015840 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1116391015841 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1116391015842 nucleotide binding site [chemical binding]; other site 1116391015843 NEF interaction site [polypeptide binding]; other site 1116391015844 SBD interface [polypeptide binding]; other site 1116391015845 GrpE; Region: GrpE; pfam01025 1116391015846 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1116391015847 dimer interface [polypeptide binding]; other site 1116391015848 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1116391015849 chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309 1116391015850 thermosome, various subunits, archaeal; Region: thermosome_arch; TIGR02339 1116391015851 ATP/Mg binding site [chemical binding]; other site 1116391015852 ring oligomerisation interface [polypeptide binding]; other site 1116391015853 hinge regions; other site 1116391015854 stacking interactions; other site 1116391015855 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1116391015856 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1116391015857 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1116391015858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391015859 Coenzyme A binding pocket [chemical binding]; other site 1116391015860 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1116391015861 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391015862 FeS/SAM binding site; other site 1116391015863 HemN C-terminal domain; Region: HemN_C; pfam06969 1116391015864 GTP-binding protein LepA; Provisional; Region: PRK05433 1116391015865 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1116391015866 G1 box; other site 1116391015867 putative GEF interaction site [polypeptide binding]; other site 1116391015868 GTP/Mg2+ binding site [chemical binding]; other site 1116391015869 Switch I region; other site 1116391015870 G2 box; other site 1116391015871 G3 box; other site 1116391015872 Switch II region; other site 1116391015873 G4 box; other site 1116391015874 G5 box; other site 1116391015875 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1116391015876 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1116391015877 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1116391015878 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1116391015879 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1116391015880 germination protease; Provisional; Region: PRK02858 1116391015881 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1116391015882 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1116391015883 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1116391015884 Putative zinc-finger; Region: zf-HC2; pfam13490 1116391015885 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1116391015886 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391015887 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391015888 DNA binding residues [nucleotide binding] 1116391015889 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1116391015890 EamA-like transporter family; Region: EamA; pfam00892 1116391015891 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1116391015892 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1116391015893 [2Fe-2S] cluster binding site [ion binding]; other site 1116391015894 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1116391015895 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1116391015896 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1116391015897 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1116391015898 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1116391015899 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1116391015900 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 1116391015901 Competence protein; Region: Competence; pfam03772 1116391015902 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1116391015903 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1116391015904 catalytic motif [active] 1116391015905 Zn binding site [ion binding]; other site 1116391015906 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1116391015907 late competence protein ComER; Validated; Region: PRK07680 1116391015908 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1116391015909 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1116391015910 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1116391015911 HIGH motif; other site 1116391015912 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1116391015913 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1116391015914 active site 1116391015915 KMSKS motif; other site 1116391015916 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1116391015917 tRNA binding surface [nucleotide binding]; other site 1116391015918 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1116391015919 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391015920 S-adenosylmethionine binding site [chemical binding]; other site 1116391015921 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1116391015922 S1 domain; Region: S1_2; pfam13509 1116391015923 S1 domain; Region: S1_2; pfam13509 1116391015924 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1116391015925 putative DNA binding site [nucleotide binding]; other site 1116391015926 putative Zn2+ binding site [ion binding]; other site 1116391015927 Oligomerisation domain; Region: Oligomerisation; cl00519 1116391015928 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1116391015929 Zn2+ binding site [ion binding]; other site 1116391015930 Mg2+ binding site [ion binding]; other site 1116391015931 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1116391015932 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1116391015933 active site 1116391015934 (T/H)XGH motif; other site 1116391015935 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1116391015936 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1116391015937 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1116391015938 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1116391015939 shikimate binding site; other site 1116391015940 NAD(P) binding site [chemical binding]; other site 1116391015941 GTPase YqeH; Provisional; Region: PRK13796 1116391015942 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1116391015943 GTP/Mg2+ binding site [chemical binding]; other site 1116391015944 G4 box; other site 1116391015945 G5 box; other site 1116391015946 G1 box; other site 1116391015947 Switch I region; other site 1116391015948 G2 box; other site 1116391015949 G3 box; other site 1116391015950 Switch II region; other site 1116391015951 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 1116391015952 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391015953 active site 1116391015954 motif I; other site 1116391015955 motif II; other site 1116391015956 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1116391015957 dimanganese center [ion binding]; other site 1116391015958 CotJB protein; Region: CotJB; pfam12652 1116391015959 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 1116391015960 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1116391015961 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1116391015962 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1116391015963 Protein of unknown function DUF58; Region: DUF58; pfam01882 1116391015964 MoxR-like ATPases [General function prediction only]; Region: COG0714 1116391015965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391015966 Walker A motif; other site 1116391015967 ATP binding site [chemical binding]; other site 1116391015968 Walker B motif; other site 1116391015969 arginine finger; other site 1116391015970 SpoVA protein; Region: SpoVA; cl04298 1116391015971 stage V sporulation protein AD; Provisional; Region: PRK12404 1116391015972 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 1116391015973 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 1116391015974 Predicted membrane protein [Function unknown]; Region: COG2323 1116391015975 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1116391015976 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1116391015977 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1116391015978 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1116391015979 ligand binding site [chemical binding]; other site 1116391015980 flexible hinge region; other site 1116391015981 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1116391015982 putative switch regulator; other site 1116391015983 non-specific DNA interactions [nucleotide binding]; other site 1116391015984 DNA binding site [nucleotide binding] 1116391015985 sequence specific DNA binding site [nucleotide binding]; other site 1116391015986 putative cAMP binding site [chemical binding]; other site 1116391015987 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391015988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391015989 active site 1116391015990 phosphorylation site [posttranslational modification] 1116391015991 intermolecular recognition site; other site 1116391015992 dimerization interface [polypeptide binding]; other site 1116391015993 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 1116391015994 Repair protein; Region: Repair_PSII; pfam04536 1116391015995 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1116391015996 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391015997 Coenzyme A binding pocket [chemical binding]; other site 1116391015998 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 1116391015999 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1116391016000 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391016001 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 1116391016002 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1116391016003 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391016004 NAD(P) binding site [chemical binding]; other site 1116391016005 active site 1116391016006 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391016007 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1116391016008 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1116391016009 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391016010 dimerization interface [polypeptide binding]; other site 1116391016011 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391016012 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391016013 dimer interface [polypeptide binding]; other site 1116391016014 putative CheW interface [polypeptide binding]; other site 1116391016015 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391016016 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1116391016017 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391016018 Walker A/P-loop; other site 1116391016019 ATP binding site [chemical binding]; other site 1116391016020 Q-loop/lid; other site 1116391016021 ABC transporter signature motif; other site 1116391016022 Walker B; other site 1116391016023 D-loop; other site 1116391016024 H-loop/switch region; other site 1116391016025 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391016026 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391016027 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1116391016028 Walker A/P-loop; other site 1116391016029 ATP binding site [chemical binding]; other site 1116391016030 Q-loop/lid; other site 1116391016031 ABC transporter signature motif; other site 1116391016032 Walker B; other site 1116391016033 D-loop; other site 1116391016034 H-loop/switch region; other site 1116391016035 MULE transposase domain; Region: MULE; pfam10551 1116391016036 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1116391016037 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1116391016038 Walker A/P-loop; other site 1116391016039 ATP binding site [chemical binding]; other site 1116391016040 Q-loop/lid; other site 1116391016041 ABC transporter signature motif; other site 1116391016042 Walker B; other site 1116391016043 D-loop; other site 1116391016044 H-loop/switch region; other site 1116391016045 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1116391016046 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016047 dimer interface [polypeptide binding]; other site 1116391016048 conserved gate region; other site 1116391016049 putative PBP binding loops; other site 1116391016050 ABC-ATPase subunit interface; other site 1116391016051 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1116391016052 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391016053 substrate binding pocket [chemical binding]; other site 1116391016054 membrane-bound complex binding site; other site 1116391016055 hinge residues; other site 1116391016056 drug efflux system protein MdtG; Provisional; Region: PRK09874 1116391016057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391016058 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1116391016059 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1116391016060 putative transposase OrfB; Reviewed; Region: PHA02517 1116391016061 HTH-like domain; Region: HTH_21; pfam13276 1116391016062 Integrase core domain; Region: rve; pfam00665 1116391016063 Integrase core domain; Region: rve_3; pfam13683 1116391016064 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391016065 Transposase; Region: HTH_Tnp_1; cl17663 1116391016066 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1116391016067 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1116391016068 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 1116391016069 active site 1116391016070 catalytic site [active] 1116391016071 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391016072 dimerization interface [polypeptide binding]; other site 1116391016073 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391016074 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391016075 dimer interface [polypeptide binding]; other site 1116391016076 putative CheW interface [polypeptide binding]; other site 1116391016077 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1116391016078 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1116391016079 ligand binding site [chemical binding]; other site 1116391016080 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391016081 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391016082 active site 1116391016083 phosphorylation site [posttranslational modification] 1116391016084 intermolecular recognition site; other site 1116391016085 dimerization interface [polypeptide binding]; other site 1116391016086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391016087 dimer interface [polypeptide binding]; other site 1116391016088 phosphorylation site [posttranslational modification] 1116391016089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391016090 ATP binding site [chemical binding]; other site 1116391016091 Mg2+ binding site [ion binding]; other site 1116391016092 G-X-G motif; other site 1116391016093 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 1116391016094 CheB methylesterase; Region: CheB_methylest; pfam01339 1116391016095 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1116391016096 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1116391016097 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1116391016098 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1116391016099 active site 1116391016100 intersubunit interactions; other site 1116391016101 catalytic residue [active] 1116391016102 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1116391016103 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1116391016104 TPP-binding site [chemical binding]; other site 1116391016105 dimer interface [polypeptide binding]; other site 1116391016106 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1116391016107 PYR/PP interface [polypeptide binding]; other site 1116391016108 dimer interface [polypeptide binding]; other site 1116391016109 TPP binding site [chemical binding]; other site 1116391016110 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1116391016111 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391016112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391016113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391016114 dimerization interface [polypeptide binding]; other site 1116391016115 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391016116 dimerization interface [polypeptide binding]; other site 1116391016117 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391016118 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391016119 dimer interface [polypeptide binding]; other site 1116391016120 putative CheW interface [polypeptide binding]; other site 1116391016121 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1116391016122 CoenzymeA binding site [chemical binding]; other site 1116391016123 subunit interaction site [polypeptide binding]; other site 1116391016124 PHB binding site; other site 1116391016125 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1116391016126 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1116391016127 acyl-activating enzyme (AAE) consensus motif; other site 1116391016128 putative AMP binding site [chemical binding]; other site 1116391016129 putative active site [active] 1116391016130 putative CoA binding site [chemical binding]; other site 1116391016131 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1116391016132 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1116391016133 active site 1116391016134 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 1116391016135 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1116391016136 dimer interface [polypeptide binding]; other site 1116391016137 active site 1116391016138 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1116391016139 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1116391016140 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1116391016141 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1116391016142 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1116391016143 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1116391016144 substrate binding site [chemical binding]; other site 1116391016145 oxyanion hole (OAH) forming residues; other site 1116391016146 trimer interface [polypeptide binding]; other site 1116391016147 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1116391016148 4Fe-4S binding domain; Region: Fer4; cl02805 1116391016149 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1116391016150 Cysteine-rich domain; Region: CCG; pfam02754 1116391016151 Cysteine-rich domain; Region: CCG; pfam02754 1116391016152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391016153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391016154 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1116391016155 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1116391016156 Ligand binding site [chemical binding]; other site 1116391016157 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1116391016158 uracil transporter; Provisional; Region: PRK10720 1116391016159 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391016160 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1116391016161 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391016162 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391016163 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391016164 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1116391016165 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1116391016166 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391016167 substrate binding pocket [chemical binding]; other site 1116391016168 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1116391016169 membrane-bound complex binding site; other site 1116391016170 hinge residues; other site 1116391016171 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1116391016172 regulatory protein interface [polypeptide binding]; other site 1116391016173 active site 1116391016174 regulatory phosphorylation site [posttranslational modification]; other site 1116391016175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 1116391016176 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 1116391016177 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1116391016178 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1116391016179 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391016180 putative active site [active] 1116391016181 heme pocket [chemical binding]; other site 1116391016182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391016183 ATP binding site [chemical binding]; other site 1116391016184 Mg2+ binding site [ion binding]; other site 1116391016185 G-X-G motif; other site 1116391016186 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1116391016187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391016188 active site 1116391016189 phosphorylation site [posttranslational modification] 1116391016190 intermolecular recognition site; other site 1116391016191 dimerization interface [polypeptide binding]; other site 1116391016192 Transcriptional regulator; Region: CitT; pfam12431 1116391016193 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1116391016194 LysE type translocator; Region: LysE; pfam01810 1116391016195 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1116391016196 Spore germination protein; Region: Spore_permease; cl17796 1116391016197 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1116391016198 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1116391016199 active site 1116391016200 non-prolyl cis peptide bond; other site 1116391016201 Predicted transcriptional regulator [Transcription]; Region: COG4189 1116391016202 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391016203 dimerization interface [polypeptide binding]; other site 1116391016204 putative DNA binding site [nucleotide binding]; other site 1116391016205 putative Zn2+ binding site [ion binding]; other site 1116391016206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1116391016207 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1116391016208 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1116391016209 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1116391016210 active site 1116391016211 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391016212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016213 dimer interface [polypeptide binding]; other site 1116391016214 conserved gate region; other site 1116391016215 putative PBP binding loops; other site 1116391016216 ABC-ATPase subunit interface; other site 1116391016217 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391016218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016219 dimer interface [polypeptide binding]; other site 1116391016220 ABC-ATPase subunit interface; other site 1116391016221 putative PBP binding loops; other site 1116391016222 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391016223 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391016224 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1116391016225 active site 1116391016226 Predicted transcriptional regulator [Transcription]; Region: COG4189 1116391016227 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391016228 dimerization interface [polypeptide binding]; other site 1116391016229 putative DNA binding site [nucleotide binding]; other site 1116391016230 putative Zn2+ binding site [ion binding]; other site 1116391016231 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391016232 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1116391016233 Metal-binding active site; metal-binding site 1116391016234 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391016235 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391016236 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016237 alpha-galactosidase; Region: PLN02808; cl17638 1116391016238 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391016239 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391016240 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391016241 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1116391016242 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1116391016243 intersubunit interface [polypeptide binding]; other site 1116391016244 active site 1116391016245 zinc binding site [ion binding]; other site 1116391016246 Na+ binding site [ion binding]; other site 1116391016247 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 1116391016248 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 1116391016249 tetrameric interface [polypeptide binding]; other site 1116391016250 NAD binding site [chemical binding]; other site 1116391016251 catalytic residues [active] 1116391016252 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391016253 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 1116391016254 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1116391016255 PYR/PP interface [polypeptide binding]; other site 1116391016256 dimer interface [polypeptide binding]; other site 1116391016257 TPP binding site [chemical binding]; other site 1116391016258 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1116391016259 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 1116391016260 TPP-binding site; other site 1116391016261 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391016262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016263 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1116391016264 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1116391016265 siderophore binding site; other site 1116391016266 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1116391016267 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391016268 dimer interface [polypeptide binding]; other site 1116391016269 putative PBP binding regions; other site 1116391016270 ABC-ATPase subunit interface; other site 1116391016271 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1116391016272 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391016273 ABC-ATPase subunit interface; other site 1116391016274 dimer interface [polypeptide binding]; other site 1116391016275 putative PBP binding regions; other site 1116391016276 Predicted ATPase [General function prediction only]; Region: COG3910 1116391016277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391016278 Walker A/P-loop; other site 1116391016279 ATP binding site [chemical binding]; other site 1116391016280 Q-loop/lid; other site 1116391016281 ABC transporter signature motif; other site 1116391016282 Walker B; other site 1116391016283 D-loop; other site 1116391016284 H-loop/switch region; other site 1116391016285 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391016286 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1116391016287 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1116391016288 inhibitor binding site; inhibition site 1116391016289 active site 1116391016290 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391016291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016292 dimer interface [polypeptide binding]; other site 1116391016293 conserved gate region; other site 1116391016294 putative PBP binding loops; other site 1116391016295 ABC-ATPase subunit interface; other site 1116391016296 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391016297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016298 dimer interface [polypeptide binding]; other site 1116391016299 conserved gate region; other site 1116391016300 ABC-ATPase subunit interface; other site 1116391016301 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016302 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391016303 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016304 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1116391016305 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1116391016306 active site 1116391016307 Pectate lyase; Region: Pec_lyase_C; cl01593 1116391016308 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391016309 Interdomain contacts; other site 1116391016310 Cytokine receptor motif; other site 1116391016311 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391016312 Interdomain contacts; other site 1116391016313 Cytokine receptor motif; other site 1116391016314 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391016315 Interdomain contacts; other site 1116391016316 Cytokine receptor motif; other site 1116391016317 putative pectinesterase; Region: PLN02432; cl01911 1116391016318 Pectinesterase; Region: Pectinesterase; pfam01095 1116391016319 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 1116391016320 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 1116391016321 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1116391016322 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1116391016323 putative metal binding site; other site 1116391016324 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1116391016325 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1116391016326 binding surface 1116391016327 TPR motif; other site 1116391016328 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1116391016329 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1116391016330 active site 1116391016331 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1116391016332 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391016333 putative homodimer interface [polypeptide binding]; other site 1116391016334 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1116391016335 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1116391016336 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 1116391016337 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391016338 putative homodimer interface [polypeptide binding]; other site 1116391016339 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1116391016340 metal binding site [ion binding]; metal-binding site 1116391016341 active site 1116391016342 Putative esterase; Region: Esterase; pfam00756 1116391016343 S-formylglutathione hydrolase; Region: PLN02442 1116391016344 Putative esterase; Region: Esterase; pfam00756 1116391016345 S-layer homology domain; Region: SLH; pfam00395 1116391016346 S-layer homology domain; Region: SLH; pfam00395 1116391016347 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1116391016348 active site 1116391016349 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 1116391016350 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 1116391016351 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391016352 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391016353 homodimer interface [polypeptide binding]; other site 1116391016354 catalytic residue [active] 1116391016355 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391016356 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016357 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391016358 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016359 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1116391016360 catalytic core [active] 1116391016361 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391016362 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391016363 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1116391016364 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1116391016365 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 1116391016366 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1116391016367 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391016368 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391016369 DNA binding site [nucleotide binding] 1116391016370 domain linker motif; other site 1116391016371 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1116391016372 dimerization interface [polypeptide binding]; other site 1116391016373 ligand binding site [chemical binding]; other site 1116391016374 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1116391016375 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391016376 Interdomain contacts; other site 1116391016377 Cytokine receptor motif; other site 1116391016378 Cellulose binding domain; Region: CBM_3; pfam00942 1116391016379 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 1116391016380 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1116391016381 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391016382 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391016383 Interdomain contacts; other site 1116391016384 Cytokine receptor motif; other site 1116391016385 Cellulose binding domain; Region: CBM_3; pfam00942 1116391016386 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1116391016387 dimer interface [polypeptide binding]; other site 1116391016388 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391016389 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1116391016390 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391016391 Coenzyme A binding pocket [chemical binding]; other site 1116391016392 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1116391016393 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1116391016394 active site 1116391016395 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391016396 Putative transcription activator [Transcription]; Region: TenA; COG0819 1116391016397 acetylornithine deacetylase; Validated; Region: PRK08596 1116391016398 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1116391016399 metal binding site [ion binding]; metal-binding site 1116391016400 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1116391016401 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391016402 Walker A/P-loop; other site 1116391016403 ATP binding site [chemical binding]; other site 1116391016404 Q-loop/lid; other site 1116391016405 ABC transporter signature motif; other site 1116391016406 Walker B; other site 1116391016407 D-loop; other site 1116391016408 H-loop/switch region; other site 1116391016409 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1116391016410 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1116391016411 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1116391016412 Walker A/P-loop; other site 1116391016413 ATP binding site [chemical binding]; other site 1116391016414 Q-loop/lid; other site 1116391016415 ABC transporter signature motif; other site 1116391016416 Walker B; other site 1116391016417 D-loop; other site 1116391016418 H-loop/switch region; other site 1116391016419 BioY family; Region: BioY; pfam02632 1116391016420 Glycosyl hydrolase family 43; Region: GH43_5; cd08984 1116391016421 active site 1116391016422 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1116391016423 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1116391016424 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391016425 DNA-binding site [nucleotide binding]; DNA binding site 1116391016426 FCD domain; Region: FCD; pfam07729 1116391016427 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1116391016428 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1116391016429 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1116391016430 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1116391016431 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1116391016432 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1116391016433 Cysteine-rich domain; Region: CCG; pfam02754 1116391016434 Cysteine-rich domain; Region: CCG; pfam02754 1116391016435 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1116391016436 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1116391016437 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1116391016438 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1116391016439 N- and C-terminal domain interface [polypeptide binding]; other site 1116391016440 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1116391016441 active site 1116391016442 putative catalytic site [active] 1116391016443 metal binding site [ion binding]; metal-binding site 1116391016444 ATP binding site [chemical binding]; other site 1116391016445 carbohydrate binding site [chemical binding]; other site 1116391016446 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 1116391016447 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1116391016448 Anabaena sensory rhodopsin transducer; Region: ASRT; cl01751 1116391016449 short chain dehydrogenase; Validated; Region: PRK08324 1116391016450 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1116391016451 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1116391016452 putative NAD(P) binding site [chemical binding]; other site 1116391016453 active site 1116391016454 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1116391016455 intersubunit interface [polypeptide binding]; other site 1116391016456 active site 1116391016457 Zn2+ binding site [ion binding]; other site 1116391016458 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1116391016459 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1116391016460 active site 1116391016461 intersubunit interface [polypeptide binding]; other site 1116391016462 Zn2+ binding site [ion binding]; other site 1116391016463 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1116391016464 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391016465 MarR family; Region: MarR_2; pfam12802 1116391016466 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391016467 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391016468 putative substrate translocation pore; other site 1116391016469 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391016470 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1116391016471 NAD(P) binding site [chemical binding]; other site 1116391016472 active site 1116391016473 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391016474 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391016475 active site 1116391016476 phosphorylation site [posttranslational modification] 1116391016477 intermolecular recognition site; other site 1116391016478 dimerization interface [polypeptide binding]; other site 1116391016479 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391016480 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016481 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1116391016482 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1116391016483 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1116391016484 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391016485 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391016486 homodimer interface [polypeptide binding]; other site 1116391016487 catalytic residue [active] 1116391016488 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1116391016489 active site 1116391016490 catalytic triad [active] 1116391016491 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1116391016492 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391016493 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016494 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391016495 Predicted membrane protein [Function unknown]; Region: COG4709 1116391016496 Regulatory protein YrvL; Region: YrvL; pfam14184 1116391016497 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 1116391016498 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1116391016499 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 1116391016500 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1116391016501 dimerization interface [polypeptide binding]; other site 1116391016502 NAD binding site [chemical binding]; other site 1116391016503 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1116391016504 ligand binding site [chemical binding]; other site 1116391016505 catalytic site [active] 1116391016506 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391016507 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391016508 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1116391016509 Walker A/P-loop; other site 1116391016510 ATP binding site [chemical binding]; other site 1116391016511 Q-loop/lid; other site 1116391016512 ABC transporter signature motif; other site 1116391016513 Walker B; other site 1116391016514 D-loop; other site 1116391016515 H-loop/switch region; other site 1116391016516 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391016517 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391016518 metal binding site [ion binding]; metal-binding site 1116391016519 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 1116391016520 substrate binding site [chemical binding]; other site 1116391016521 active site 1116391016522 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 1116391016523 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1116391016524 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1116391016525 S-layer homology domain; Region: SLH; pfam00395 1116391016526 S-layer homology domain; Region: SLH; pfam00395 1116391016527 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1116391016528 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391016529 substrate binding pocket [chemical binding]; other site 1116391016530 membrane-bound complex binding site; other site 1116391016531 hinge residues; other site 1116391016532 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1116391016533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016534 dimer interface [polypeptide binding]; other site 1116391016535 conserved gate region; other site 1116391016536 putative PBP binding loops; other site 1116391016537 ABC-ATPase subunit interface; other site 1116391016538 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1116391016539 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1116391016540 Walker A/P-loop; other site 1116391016541 ATP binding site [chemical binding]; other site 1116391016542 Q-loop/lid; other site 1116391016543 ABC transporter signature motif; other site 1116391016544 Walker B; other site 1116391016545 D-loop; other site 1116391016546 H-loop/switch region; other site 1116391016547 Peptidase C26; Region: Peptidase_C26; pfam07722 1116391016548 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1116391016549 catalytic triad [active] 1116391016550 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1116391016551 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1116391016552 nucleotide binding site [chemical binding]; other site 1116391016553 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391016554 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1116391016555 NlpC/P60 family; Region: NLPC_P60; pfam00877 1116391016556 Transglycosylase; Region: Transgly; pfam00912 1116391016557 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1116391016558 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1116391016559 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 1116391016560 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1116391016561 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1116391016562 putative pectinesterase; Region: PLN02432; cl01911 1116391016563 YhfH-like protein; Region: YhfH; pfam14149 1116391016564 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1116391016565 Protein export membrane protein; Region: SecD_SecF; cl14618 1116391016566 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1116391016567 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 1116391016568 DNA binding residues [nucleotide binding] 1116391016569 drug binding residues [chemical binding]; other site 1116391016570 dimer interface [polypeptide binding]; other site 1116391016571 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1116391016572 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391016573 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391016574 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391016575 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391016576 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1116391016577 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1116391016578 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1116391016579 metal-binding site [ion binding] 1116391016580 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1116391016581 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1116391016582 metal-binding site [ion binding] 1116391016583 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1116391016584 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391016585 motif II; other site 1116391016586 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1116391016587 metal-binding site [ion binding] 1116391016588 Arginase family; Region: Arginase; cd09989 1116391016589 active site 1116391016590 Mn binding site [ion binding]; other site 1116391016591 oligomer interface [polypeptide binding]; other site 1116391016592 Arginase family; Region: Arginase; cd09989 1116391016593 active site 1116391016594 Mn binding site [ion binding]; other site 1116391016595 oligomer interface [polypeptide binding]; other site 1116391016596 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391016597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391016598 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391016599 dimerization interface [polypeptide binding]; other site 1116391016600 S-methylmethionine transporter; Provisional; Region: PRK11387 1116391016601 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1116391016602 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1116391016603 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1116391016604 NAD(P) binding site [chemical binding]; other site 1116391016605 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 1116391016606 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1116391016607 inhibitor-cofactor binding pocket; inhibition site 1116391016608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391016609 catalytic residue [active] 1116391016610 PAS domain; Region: PAS; smart00091 1116391016611 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391016612 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1116391016613 Walker A motif; other site 1116391016614 ATP binding site [chemical binding]; other site 1116391016615 Walker B motif; other site 1116391016616 arginine finger; other site 1116391016617 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1116391016618 active site 1116391016619 hypothetical protein; Provisional; Region: PRK09739 1116391016620 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1116391016621 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391016622 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391016623 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391016624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391016625 active site 1116391016626 phosphorylation site [posttranslational modification] 1116391016627 intermolecular recognition site; other site 1116391016628 dimerization interface [polypeptide binding]; other site 1116391016629 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016630 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391016631 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016632 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391016633 dimerization interface [polypeptide binding]; other site 1116391016634 Histidine kinase; Region: His_kinase; pfam06580 1116391016635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391016636 ATP binding site [chemical binding]; other site 1116391016637 G-X-G motif; other site 1116391016638 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391016639 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391016640 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391016641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016642 dimer interface [polypeptide binding]; other site 1116391016643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391016644 ABC-ATPase subunit interface; other site 1116391016645 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391016646 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1116391016647 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391016648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016649 dimer interface [polypeptide binding]; other site 1116391016650 conserved gate region; other site 1116391016651 putative PBP binding loops; other site 1116391016652 ABC-ATPase subunit interface; other site 1116391016653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016654 dimer interface [polypeptide binding]; other site 1116391016655 conserved gate region; other site 1116391016656 putative PBP binding loops; other site 1116391016657 ABC-ATPase subunit interface; other site 1116391016658 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391016659 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391016660 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391016661 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391016662 dimerization interface [polypeptide binding]; other site 1116391016663 Histidine kinase; Region: His_kinase; pfam06580 1116391016664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391016665 ATP binding site [chemical binding]; other site 1116391016666 Mg2+ binding site [ion binding]; other site 1116391016667 G-X-G motif; other site 1116391016668 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1116391016669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391016670 active site 1116391016671 phosphorylation site [posttranslational modification] 1116391016672 intermolecular recognition site; other site 1116391016673 dimerization interface [polypeptide binding]; other site 1116391016674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016675 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1116391016676 putative FMN binding site [chemical binding]; other site 1116391016677 NADPH bind site [chemical binding]; other site 1116391016678 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1116391016679 putative FMN binding site [chemical binding]; other site 1116391016680 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1116391016681 YcaO-like family; Region: YcaO; pfam02624 1116391016682 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 1116391016683 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 1116391016684 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 1116391016685 DinB superfamily; Region: DinB_2; pfam12867 1116391016686 Protein of unknown function (DUF664); Region: DUF664; pfam04978 1116391016687 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1116391016688 classical (c) SDRs; Region: SDR_c; cd05233 1116391016689 NAD(P) binding site [chemical binding]; other site 1116391016690 active site 1116391016691 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1116391016692 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1116391016693 active site 1 [active] 1116391016694 dimer interface [polypeptide binding]; other site 1116391016695 hexamer interface [polypeptide binding]; other site 1116391016696 active site 2 [active] 1116391016697 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391016698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391016699 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391016700 dimerization interface [polypeptide binding]; other site 1116391016701 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391016702 dimerization interface [polypeptide binding]; other site 1116391016703 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391016704 Histidine kinase; Region: His_kinase; pfam06580 1116391016705 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391016706 ATP binding site [chemical binding]; other site 1116391016707 Mg2+ binding site [ion binding]; other site 1116391016708 G-X-G motif; other site 1116391016709 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391016710 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391016711 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391016712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016713 dimer interface [polypeptide binding]; other site 1116391016714 conserved gate region; other site 1116391016715 putative PBP binding loops; other site 1116391016716 ABC-ATPase subunit interface; other site 1116391016717 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391016718 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1116391016719 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1116391016720 sugar binding site [chemical binding]; other site 1116391016721 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1116391016722 sugar binding site [chemical binding]; other site 1116391016723 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 1116391016724 Cupin; Region: Cupin_1; smart00835 1116391016725 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391016726 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391016727 DNA binding site [nucleotide binding] 1116391016728 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1116391016729 Domain of unknown function (DUF336); Region: DUF336; cl01249 1116391016730 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 1116391016731 active site 1116391016732 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391016733 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391016734 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1116391016735 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391016736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016737 dimer interface [polypeptide binding]; other site 1116391016738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391016739 ABC-ATPase subunit interface; other site 1116391016740 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391016741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016742 dimer interface [polypeptide binding]; other site 1116391016743 conserved gate region; other site 1116391016744 ABC-ATPase subunit interface; other site 1116391016745 Cache domain; Region: Cache_1; pfam02743 1116391016746 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391016747 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391016748 metal binding site [ion binding]; metal-binding site 1116391016749 active site 1116391016750 I-site; other site 1116391016751 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1116391016752 NADP binding site [chemical binding]; other site 1116391016753 active site 1116391016754 steroid binding site; other site 1116391016755 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391016756 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391016757 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1116391016758 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1116391016759 putative ligand binding site [chemical binding]; other site 1116391016760 Cache domain; Region: Cache_1; pfam02743 1116391016761 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391016762 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391016763 dimerization interface [polypeptide binding]; other site 1116391016764 Histidine kinase; Region: His_kinase; pfam06580 1116391016765 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391016766 ATP binding site [chemical binding]; other site 1116391016767 Mg2+ binding site [ion binding]; other site 1116391016768 G-X-G motif; other site 1116391016769 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391016770 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391016771 active site 1116391016772 phosphorylation site [posttranslational modification] 1116391016773 intermolecular recognition site; other site 1116391016774 dimerization interface [polypeptide binding]; other site 1116391016775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016776 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391016777 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016778 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1116391016779 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1116391016780 putative ligand binding site [chemical binding]; other site 1116391016781 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391016782 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1116391016783 TM-ABC transporter signature motif; other site 1116391016784 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1116391016785 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1116391016786 Walker A/P-loop; other site 1116391016787 ATP binding site [chemical binding]; other site 1116391016788 Q-loop/lid; other site 1116391016789 ABC transporter signature motif; other site 1116391016790 Walker B; other site 1116391016791 D-loop; other site 1116391016792 H-loop/switch region; other site 1116391016793 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1116391016794 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1116391016795 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016796 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391016797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016798 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1116391016799 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 1116391016800 metal binding site [ion binding]; metal-binding site 1116391016801 substrate binding pocket [chemical binding]; other site 1116391016802 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1116391016803 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1116391016804 NAD(P) binding site [chemical binding]; other site 1116391016805 catalytic residues [active] 1116391016806 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391016807 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391016808 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016809 dimer interface [polypeptide binding]; other site 1116391016810 conserved gate region; other site 1116391016811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1116391016812 ABC-ATPase subunit interface; other site 1116391016813 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 1116391016814 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391016815 Walker A/P-loop; other site 1116391016816 ATP binding site [chemical binding]; other site 1116391016817 Q-loop/lid; other site 1116391016818 ABC transporter signature motif; other site 1116391016819 Walker B; other site 1116391016820 D-loop; other site 1116391016821 H-loop/switch region; other site 1116391016822 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1116391016823 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1116391016824 Walker A/P-loop; other site 1116391016825 ATP binding site [chemical binding]; other site 1116391016826 Q-loop/lid; other site 1116391016827 ABC transporter signature motif; other site 1116391016828 Walker B; other site 1116391016829 D-loop; other site 1116391016830 H-loop/switch region; other site 1116391016831 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1116391016832 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1116391016833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016834 dimer interface [polypeptide binding]; other site 1116391016835 conserved gate region; other site 1116391016836 putative PBP binding loops; other site 1116391016837 ABC-ATPase subunit interface; other site 1116391016838 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 1116391016839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016840 dimer interface [polypeptide binding]; other site 1116391016841 conserved gate region; other site 1116391016842 putative PBP binding loops; other site 1116391016843 ABC-ATPase subunit interface; other site 1116391016844 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1116391016845 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1116391016846 substrate binding site [chemical binding]; other site 1116391016847 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391016848 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391016849 putative substrate translocation pore; other site 1116391016850 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1116391016851 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1116391016852 putative N- and C-terminal domain interface [polypeptide binding]; other site 1116391016853 putative active site [active] 1116391016854 MgATP binding site [chemical binding]; other site 1116391016855 catalytic site [active] 1116391016856 metal binding site [ion binding]; metal-binding site 1116391016857 putative carbohydrate binding site [chemical binding]; other site 1116391016858 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391016859 Helix-turn-helix domain; Region: HTH_18; pfam12833 1116391016860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016861 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1116391016862 putative catalytic site [active] 1116391016863 putative metal binding site [ion binding]; other site 1116391016864 putative phosphate binding site [ion binding]; other site 1116391016865 Jacalin-like lectin domains of putative endonucleases/exonucleases/phosphatases and related proteins; Region: Jacalin_EEP; cd09615 1116391016866 putative sugar binding site [chemical binding]; other site 1116391016867 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1116391016868 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1116391016869 active site 1116391016870 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 1116391016871 S-layer homology domain; Region: SLH; pfam00395 1116391016872 S-layer homology domain; Region: SLH; pfam00395 1116391016873 S-layer homology domain; Region: SLH; pfam00395 1116391016874 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1116391016875 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1116391016876 FtsX-like permease family; Region: FtsX; pfam02687 1116391016877 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1116391016878 FtsX-like permease family; Region: FtsX; pfam02687 1116391016879 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1116391016880 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1116391016881 Walker A/P-loop; other site 1116391016882 ATP binding site [chemical binding]; other site 1116391016883 Q-loop/lid; other site 1116391016884 ABC transporter signature motif; other site 1116391016885 Walker B; other site 1116391016886 D-loop; other site 1116391016887 H-loop/switch region; other site 1116391016888 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1116391016889 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391016890 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391016891 DNA binding residues [nucleotide binding] 1116391016892 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391016893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391016894 dimer interface [polypeptide binding]; other site 1116391016895 conserved gate region; other site 1116391016896 ABC-ATPase subunit interface; other site 1116391016897 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1116391016898 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391016899 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1116391016900 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391016901 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391016902 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1116391016903 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1116391016904 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1116391016905 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1116391016906 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391016907 putative DNA binding site [nucleotide binding]; other site 1116391016908 putative Zn2+ binding site [ion binding]; other site 1116391016909 AsnC family; Region: AsnC_trans_reg; pfam01037 1116391016910 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1116391016911 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1116391016912 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 1116391016913 putative active site [active] 1116391016914 putative metal binding site [ion binding]; other site 1116391016915 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1116391016916 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1116391016917 generic binding surface I; other site 1116391016918 generic binding surface II; other site 1116391016919 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1116391016920 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391016921 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391016922 DNA binding residues [nucleotide binding] 1116391016923 dimerization interface [polypeptide binding]; other site 1116391016924 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1116391016925 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 1116391016926 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1116391016927 acyl-activating enzyme (AAE) consensus motif; other site 1116391016928 putative AMP binding site [chemical binding]; other site 1116391016929 putative active site [active] 1116391016930 putative CoA binding site [chemical binding]; other site 1116391016931 Protein of unknown function (DUF429); Region: DUF429; cl12046 1116391016932 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 1116391016933 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1116391016934 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1116391016935 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1116391016936 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1116391016937 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1116391016938 HlyD family secretion protein; Region: HlyD_3; pfam13437 1116391016939 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391016940 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391016941 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1116391016942 Melibiase; Region: Melibiase; pfam02065 1116391016943 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1116391016944 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1116391016945 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1116391016946 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1116391016947 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1116391016948 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1116391016949 E3 interaction surface; other site 1116391016950 lipoyl attachment site [posttranslational modification]; other site 1116391016951 e3 binding domain; Region: E3_binding; pfam02817 1116391016952 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1116391016953 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1116391016954 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1116391016955 alpha subunit interface [polypeptide binding]; other site 1116391016956 TPP binding site [chemical binding]; other site 1116391016957 heterodimer interface [polypeptide binding]; other site 1116391016958 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1116391016959 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1116391016960 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1116391016961 TPP-binding site [chemical binding]; other site 1116391016962 heterodimer interface [polypeptide binding]; other site 1116391016963 tetramer interface [polypeptide binding]; other site 1116391016964 phosphorylation loop region [posttranslational modification] 1116391016965 Putative esterase; Region: Esterase; pfam00756 1116391016966 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1116391016967 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1116391016968 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 1116391016969 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 1116391016970 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391016971 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1116391016972 active site 1116391016973 metal binding site [ion binding]; metal-binding site 1116391016974 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 1116391016975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391016976 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391016977 active site 1116391016978 phosphorylation site [posttranslational modification] 1116391016979 intermolecular recognition site; other site 1116391016980 dimerization interface [polypeptide binding]; other site 1116391016981 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1116391016982 GAF domain; Region: GAF_3; pfam13492 1116391016983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4878 1116391016984 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 1116391016985 NodB motif; other site 1116391016986 putative active site [active] 1116391016987 putative catalytic site [active] 1116391016988 putative Zn binding site [ion binding]; other site 1116391016989 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 1116391016990 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391016991 Predicted membrane protein [Function unknown]; Region: COG4267 1116391016992 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391016993 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391016994 dimer interface [polypeptide binding]; other site 1116391016995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391016996 ATP binding site [chemical binding]; other site 1116391016997 Mg2+ binding site [ion binding]; other site 1116391016998 G-X-G motif; other site 1116391016999 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1116391017000 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1116391017001 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1116391017002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391017003 dimerization interface [polypeptide binding]; other site 1116391017004 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391017005 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391017006 dimer interface [polypeptide binding]; other site 1116391017007 putative CheW interface [polypeptide binding]; other site 1116391017008 Peptidase family U32; Region: Peptidase_U32; pfam01136 1116391017009 YceG-like family; Region: YceG; pfam02618 1116391017010 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1116391017011 dimerization interface [polypeptide binding]; other site 1116391017012 hypothetical protein; Provisional; Region: PRK13678 1116391017013 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1116391017014 hypothetical protein; Provisional; Region: PRK05473 1116391017015 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1116391017016 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1116391017017 motif 1; other site 1116391017018 active site 1116391017019 motif 2; other site 1116391017020 motif 3; other site 1116391017021 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1116391017022 DHHA1 domain; Region: DHHA1; pfam02272 1116391017023 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 1116391017024 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391017025 Spore germination protein; Region: Spore_permease; cl17796 1116391017026 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1116391017027 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1116391017028 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 1116391017029 PRC-barrel domain; Region: PRC; pfam05239 1116391017030 PRC-barrel domain; Region: PRC; pfam05239 1116391017031 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1116391017032 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1116391017033 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1116391017034 catalytic residue [active] 1116391017035 Predicted transcriptional regulator [Transcription]; Region: COG1959 1116391017036 Transcriptional regulator; Region: Rrf2; pfam02082 1116391017037 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1116391017038 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1116391017039 Ligand Binding Site [chemical binding]; other site 1116391017040 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1116391017041 Domain of unknown function DUF21; Region: DUF21; pfam01595 1116391017042 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1116391017043 Transporter associated domain; Region: CorC_HlyC; smart01091 1116391017044 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1116391017045 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1116391017046 recombination factor protein RarA; Reviewed; Region: PRK13342 1116391017047 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391017048 Walker A motif; other site 1116391017049 ATP binding site [chemical binding]; other site 1116391017050 Walker B motif; other site 1116391017051 arginine finger; other site 1116391017052 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1116391017053 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1116391017054 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1116391017055 putative ATP binding site [chemical binding]; other site 1116391017056 putative substrate interface [chemical binding]; other site 1116391017057 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1116391017058 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1116391017059 dimer interface [polypeptide binding]; other site 1116391017060 anticodon binding site; other site 1116391017061 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1116391017062 homodimer interface [polypeptide binding]; other site 1116391017063 motif 1; other site 1116391017064 active site 1116391017065 motif 2; other site 1116391017066 GAD domain; Region: GAD; pfam02938 1116391017067 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1116391017068 active site 1116391017069 motif 3; other site 1116391017070 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1116391017071 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1116391017072 dimer interface [polypeptide binding]; other site 1116391017073 motif 1; other site 1116391017074 active site 1116391017075 motif 2; other site 1116391017076 motif 3; other site 1116391017077 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1116391017078 anticodon binding site; other site 1116391017079 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1116391017080 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1116391017081 putative active site [active] 1116391017082 dimerization interface [polypeptide binding]; other site 1116391017083 putative tRNAtyr binding site [nucleotide binding]; other site 1116391017084 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1116391017085 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1116391017086 Zn2+ binding site [ion binding]; other site 1116391017087 Mg2+ binding site [ion binding]; other site 1116391017088 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1116391017089 synthetase active site [active] 1116391017090 NTP binding site [chemical binding]; other site 1116391017091 metal binding site [ion binding]; metal-binding site 1116391017092 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1116391017093 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1116391017094 CotH protein; Region: CotH; pfam08757 1116391017095 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1116391017096 active site 1116391017097 Cation efflux family; Region: Cation_efflux; cl00316 1116391017098 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1116391017099 Protein export membrane protein; Region: SecD_SecF; pfam02355 1116391017100 protein-export membrane protein SecD; Region: secD; TIGR01129 1116391017101 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1116391017102 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1116391017103 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1116391017104 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1116391017105 Predicted membrane protein [Function unknown]; Region: COG2323 1116391017106 Preprotein translocase subunit; Region: YajC; pfam02699 1116391017107 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1116391017108 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1116391017109 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1116391017110 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1116391017111 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1116391017112 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391017113 Walker A motif; other site 1116391017114 ATP binding site [chemical binding]; other site 1116391017115 Walker B motif; other site 1116391017116 arginine finger; other site 1116391017117 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1116391017118 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1116391017119 RuvA N terminal domain; Region: RuvA_N; pfam01330 1116391017120 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1116391017121 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1116391017122 active site 1116391017123 putative DNA-binding cleft [nucleotide binding]; other site 1116391017124 dimer interface [polypeptide binding]; other site 1116391017125 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1116391017126 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1116391017127 active site 1116391017128 BofC C-terminal domain; Region: BofC_C; pfam08955 1116391017129 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1116391017130 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1116391017131 Catalytic site [active] 1116391017132 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391017133 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1116391017134 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391017135 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1116391017136 MgtC family; Region: MgtC; pfam02308 1116391017137 prephenate dehydratase; Provisional; Region: PRK11898 1116391017138 Prephenate dehydratase; Region: PDT; pfam00800 1116391017139 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1116391017140 putative L-Phe binding site [chemical binding]; other site 1116391017141 homoserine kinase; Provisional; Region: PRK01212 1116391017142 homoserine dehydrogenase; Provisional; Region: PRK06349 1116391017143 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1116391017144 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1116391017145 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1116391017146 hypothetical protein; Provisional; Region: PRK04435 1116391017147 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1116391017148 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1116391017149 nudix motif; other site 1116391017150 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1116391017151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391017152 Walker A/P-loop; other site 1116391017153 ATP binding site [chemical binding]; other site 1116391017154 Q-loop/lid; other site 1116391017155 ABC transporter signature motif; other site 1116391017156 Walker B; other site 1116391017157 D-loop; other site 1116391017158 H-loop/switch region; other site 1116391017159 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 1116391017160 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1116391017161 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1116391017162 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1116391017163 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1116391017164 [4Fe-4S] binding site [ion binding]; other site 1116391017165 molybdopterin cofactor binding site; other site 1116391017166 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1116391017167 molybdopterin cofactor binding site; other site 1116391017168 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 1116391017169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391017170 putative substrate translocation pore; other site 1116391017171 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1116391017172 GTP1/OBG; Region: GTP1_OBG; pfam01018 1116391017173 Obg GTPase; Region: Obg; cd01898 1116391017174 G1 box; other site 1116391017175 GTP/Mg2+ binding site [chemical binding]; other site 1116391017176 Switch I region; other site 1116391017177 G2 box; other site 1116391017178 G3 box; other site 1116391017179 Switch II region; other site 1116391017180 G4 box; other site 1116391017181 G5 box; other site 1116391017182 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1116391017183 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1116391017184 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1116391017185 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1116391017186 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1116391017187 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1116391017188 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1116391017189 homodimer interface [polypeptide binding]; other site 1116391017190 oligonucleotide binding site [chemical binding]; other site 1116391017191 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1116391017192 Peptidase family M50; Region: Peptidase_M50; pfam02163 1116391017193 active site 1116391017194 putative substrate binding region [chemical binding]; other site 1116391017195 Peptidase family M23; Region: Peptidase_M23; pfam01551 1116391017196 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1116391017197 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1116391017198 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1116391017199 Switch I; other site 1116391017200 Switch II; other site 1116391017201 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1116391017202 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1116391017203 rod shape-determining protein MreD; Region: MreD; cl01087 1116391017204 rod shape-determining protein MreC; Provisional; Region: PRK13922 1116391017205 rod shape-determining protein MreC; Region: MreC; pfam04085 1116391017206 rod shape-determining protein MreB; Provisional; Region: PRK13927 1116391017207 MreB and similar proteins; Region: MreB_like; cd10225 1116391017208 nucleotide binding site [chemical binding]; other site 1116391017209 Mg binding site [ion binding]; other site 1116391017210 putative protofilament interaction site [polypeptide binding]; other site 1116391017211 RodZ interaction site [polypeptide binding]; other site 1116391017212 hypothetical protein; Reviewed; Region: PRK00024 1116391017213 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1116391017214 MPN+ (JAMM) motif; other site 1116391017215 Zinc-binding site [ion binding]; other site 1116391017216 Maf-like protein; Provisional; Region: PRK14361 1116391017217 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1116391017218 active site 1116391017219 dimer interface [polypeptide binding]; other site 1116391017220 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1116391017221 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1116391017222 active site 1116391017223 metal binding site [ion binding]; metal-binding site 1116391017224 S-layer homology domain; Region: SLH; pfam00395 1116391017225 S-layer homology domain; Region: SLH; pfam00395 1116391017226 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1116391017227 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1116391017228 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1116391017229 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1116391017230 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1116391017231 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1116391017232 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1116391017233 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1116391017234 active site 1116391017235 HIGH motif; other site 1116391017236 nucleotide binding site [chemical binding]; other site 1116391017237 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1116391017238 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1116391017239 active site 1116391017240 KMSKS motif; other site 1116391017241 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1116391017242 tRNA binding surface [nucleotide binding]; other site 1116391017243 anticodon binding site; other site 1116391017244 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1116391017245 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391017246 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1116391017247 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1116391017248 active site 1116391017249 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1116391017250 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1116391017251 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1116391017252 inhibitor-cofactor binding pocket; inhibition site 1116391017253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391017254 catalytic residue [active] 1116391017255 ferrochelatase; Provisional; Region: PRK12435 1116391017256 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1116391017257 C-terminal domain interface [polypeptide binding]; other site 1116391017258 active site 1116391017259 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1116391017260 active site 1116391017261 N-terminal domain interface [polypeptide binding]; other site 1116391017262 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1116391017263 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1116391017264 substrate binding site [chemical binding]; other site 1116391017265 active site 1116391017266 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1116391017267 dimer interface [polypeptide binding]; other site 1116391017268 active site 1116391017269 Schiff base residues; other site 1116391017270 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1116391017271 active site 1116391017272 SAM binding site [chemical binding]; other site 1116391017273 homodimer interface [polypeptide binding]; other site 1116391017274 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1116391017275 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1116391017276 active site 1116391017277 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1116391017278 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1116391017279 domain interfaces; other site 1116391017280 active site 1116391017281 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1116391017282 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1116391017283 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1116391017284 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1116391017285 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1116391017286 tRNA; other site 1116391017287 putative tRNA binding site [nucleotide binding]; other site 1116391017288 putative NADP binding site [chemical binding]; other site 1116391017289 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1116391017290 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 1116391017291 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1116391017292 G1 box; other site 1116391017293 GTP/Mg2+ binding site [chemical binding]; other site 1116391017294 Switch I region; other site 1116391017295 G2 box; other site 1116391017296 G3 box; other site 1116391017297 Switch II region; other site 1116391017298 G4 box; other site 1116391017299 G5 box; other site 1116391017300 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1116391017301 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1116391017302 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1116391017303 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391017304 Walker A motif; other site 1116391017305 ATP binding site [chemical binding]; other site 1116391017306 Walker B motif; other site 1116391017307 arginine finger; other site 1116391017308 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1116391017309 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1116391017310 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391017311 Walker A motif; other site 1116391017312 ATP binding site [chemical binding]; other site 1116391017313 Walker B motif; other site 1116391017314 arginine finger; other site 1116391017315 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1116391017316 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1116391017317 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1116391017318 active site 1116391017319 metal binding site [ion binding]; metal-binding site 1116391017320 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1116391017321 NodB motif; other site 1116391017322 putative active site [active] 1116391017323 putative catalytic site [active] 1116391017324 Zn binding site [ion binding]; other site 1116391017325 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1116391017326 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1116391017327 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1116391017328 Clp protease; Region: CLP_protease; pfam00574 1116391017329 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1116391017330 oligomer interface [polypeptide binding]; other site 1116391017331 active site residues [active] 1116391017332 trigger factor; Provisional; Region: tig; PRK01490 1116391017333 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1116391017334 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1116391017335 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391017336 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391017337 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391017338 Spore germination protein; Region: Spore_permease; cl17796 1116391017339 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1116391017340 active site 1116391017341 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1116391017342 dimer interface [polypeptide binding]; other site 1116391017343 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1116391017344 Ligand Binding Site [chemical binding]; other site 1116391017345 Molecular Tunnel; other site 1116391017346 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1116391017347 active site 1116391017348 dimerization interface [polypeptide binding]; other site 1116391017349 ribonuclease PH; Reviewed; Region: rph; PRK00173 1116391017350 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1116391017351 hexamer interface [polypeptide binding]; other site 1116391017352 active site 1116391017353 Sporulation and spore germination; Region: Germane; pfam10646 1116391017354 Spore germination protein [General function prediction only]; Region: COG5401 1116391017355 Sporulation and spore germination; Region: Germane; pfam10646 1116391017356 PAS domain S-box; Region: sensory_box; TIGR00229 1116391017357 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391017358 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391017359 metal binding site [ion binding]; metal-binding site 1116391017360 active site 1116391017361 I-site; other site 1116391017362 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1116391017363 tetramer interfaces [polypeptide binding]; other site 1116391017364 binuclear metal-binding site [ion binding]; other site 1116391017365 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391017366 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1116391017367 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1116391017368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391017369 S-adenosylmethionine binding site [chemical binding]; other site 1116391017370 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1116391017371 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1116391017372 nucleotide binding site [chemical binding]; other site 1116391017373 DNA-sulfur modification-associated; Region: DndB; cl17621 1116391017374 DNA-sulfur modification-associated; Region: DndB; cl17621 1116391017375 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391017376 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391017377 active site 1116391017378 phosphorylation site [posttranslational modification] 1116391017379 intermolecular recognition site; other site 1116391017380 dimerization interface [polypeptide binding]; other site 1116391017381 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391017382 DNA binding residues [nucleotide binding] 1116391017383 dimerization interface [polypeptide binding]; other site 1116391017384 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1116391017385 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391017386 ATP binding site [chemical binding]; other site 1116391017387 Mg2+ binding site [ion binding]; other site 1116391017388 G-X-G motif; other site 1116391017389 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 1116391017390 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1116391017391 putative hydrophobic ligand binding site [chemical binding]; other site 1116391017392 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 1116391017393 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391017394 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1116391017395 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1116391017396 tetramer interface [polypeptide binding]; other site 1116391017397 heme binding pocket [chemical binding]; other site 1116391017398 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1116391017399 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391017400 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391017401 DNA binding residues [nucleotide binding] 1116391017402 dimerization interface [polypeptide binding]; other site 1116391017403 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1116391017404 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 1116391017405 transmembrane helices; other site 1116391017406 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1116391017407 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1116391017408 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1116391017409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391017410 S-adenosylmethionine binding site [chemical binding]; other site 1116391017411 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1116391017412 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1116391017413 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1116391017414 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1116391017415 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1116391017416 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1116391017417 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391017418 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391017419 active site 1116391017420 phosphorylation site [posttranslational modification] 1116391017421 intermolecular recognition site; other site 1116391017422 dimerization interface [polypeptide binding]; other site 1116391017423 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391017424 DNA binding residues [nucleotide binding] 1116391017425 dimerization interface [polypeptide binding]; other site 1116391017426 Histidine kinase; Region: HisKA_3; pfam07730 1116391017427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1116391017428 ATP binding site [chemical binding]; other site 1116391017429 Mg2+ binding site [ion binding]; other site 1116391017430 G-X-G motif; other site 1116391017431 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1116391017432 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1116391017433 dimer interface [polypeptide binding]; other site 1116391017434 active site 1116391017435 CoA binding pocket [chemical binding]; other site 1116391017436 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1116391017437 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1116391017438 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1116391017439 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1116391017440 Probable Catalytic site; other site 1116391017441 metal-binding site 1116391017442 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 1116391017443 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1116391017444 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1116391017445 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1116391017446 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1116391017447 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1116391017448 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1116391017449 Probable Catalytic site; other site 1116391017450 metal-binding site 1116391017451 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1116391017452 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1116391017453 active site 1116391017454 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1116391017455 active site 1116391017456 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391017457 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1116391017458 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 1116391017459 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391017460 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1116391017461 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1116391017462 homotetramer interface [polypeptide binding]; other site 1116391017463 NADP-binding site; other site 1116391017464 substrate binding site [chemical binding]; other site 1116391017465 homodimer interface [polypeptide binding]; other site 1116391017466 active site 1116391017467 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1116391017468 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1116391017469 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1116391017470 NADP binding site [chemical binding]; other site 1116391017471 active site 1116391017472 putative substrate binding site [chemical binding]; other site 1116391017473 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1116391017474 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1116391017475 NAD binding site [chemical binding]; other site 1116391017476 substrate binding site [chemical binding]; other site 1116391017477 homodimer interface [polypeptide binding]; other site 1116391017478 active site 1116391017479 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1116391017480 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1116391017481 active site 1116391017482 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1116391017483 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391017484 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1116391017485 EcsC protein family; Region: EcsC; pfam12787 1116391017486 Cupin domain; Region: Cupin_2; pfam07883 1116391017487 O-Antigen ligase; Region: Wzy_C; pfam04932 1116391017488 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1116391017489 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391017490 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391017491 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391017492 MarR family; Region: MarR; pfam01047 1116391017493 MarR family; Region: MarR_2; cl17246 1116391017494 Pirin; Region: Pirin; pfam02678 1116391017495 Pirin-related protein [General function prediction only]; Region: COG1741 1116391017496 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 1116391017497 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1116391017498 Low-spin heme binding site [chemical binding]; other site 1116391017499 Subunit I/II interface [polypeptide binding]; other site 1116391017500 Putative Q-pathway; other site 1116391017501 Putative D-pathway homolog; other site 1116391017502 Putative alternate electron transfer pathway; other site 1116391017503 Putative water exit pathway; other site 1116391017504 Binuclear center (active site) [active] 1116391017505 Putative K-pathway homolog; other site 1116391017506 Putative proton exit pathway; other site 1116391017507 Subunit I/IIa interface [polypeptide binding]; other site 1116391017508 Electron transfer pathway; other site 1116391017509 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 1116391017510 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1116391017511 Ion channel; Region: Ion_trans_2; pfam07885 1116391017512 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1116391017513 TrkA-N domain; Region: TrkA_N; pfam02254 1116391017514 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1116391017515 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1116391017516 Na binding site [ion binding]; other site 1116391017517 Protein of unknown function, DUF485; Region: DUF485; pfam04341 1116391017518 Putative transcription activator [Transcription]; Region: TenA; COG0819 1116391017519 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1116391017520 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1116391017521 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1116391017522 Walker A/P-loop; other site 1116391017523 ATP binding site [chemical binding]; other site 1116391017524 Q-loop/lid; other site 1116391017525 ABC transporter signature motif; other site 1116391017526 Walker B; other site 1116391017527 D-loop; other site 1116391017528 H-loop/switch region; other site 1116391017529 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1116391017530 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1116391017531 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1116391017532 G1 box; other site 1116391017533 Walker A/P-loop; other site 1116391017534 GTP/Mg2+ binding site [chemical binding]; other site 1116391017535 ATP binding site [chemical binding]; other site 1116391017536 Q-loop/lid; other site 1116391017537 ABC transporter signature motif; other site 1116391017538 Walker B; other site 1116391017539 D-loop; other site 1116391017540 H-loop/switch region; other site 1116391017541 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1116391017542 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1116391017543 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391017544 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391017545 putative substrate translocation pore; other site 1116391017546 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1116391017547 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1116391017548 Zn2+ binding site [ion binding]; other site 1116391017549 Mg2+ binding site [ion binding]; other site 1116391017550 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1116391017551 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1116391017552 catalytic residue [active] 1116391017553 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391017554 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1116391017555 Cupin domain; Region: Cupin_2; pfam07883 1116391017556 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391017557 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391017558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391017559 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1116391017560 glutaminase A; Region: Gln_ase; TIGR03814 1116391017561 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391017562 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1116391017563 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1116391017564 TM-ABC transporter signature motif; other site 1116391017565 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1116391017566 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1116391017567 Walker A/P-loop; other site 1116391017568 ATP binding site [chemical binding]; other site 1116391017569 Q-loop/lid; other site 1116391017570 ABC transporter signature motif; other site 1116391017571 Walker B; other site 1116391017572 D-loop; other site 1116391017573 H-loop/switch region; other site 1116391017574 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1116391017575 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1116391017576 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1116391017577 putative ligand binding site [chemical binding]; other site 1116391017578 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 1116391017579 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391017580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391017581 active site 1116391017582 phosphorylation site [posttranslational modification] 1116391017583 intermolecular recognition site; other site 1116391017584 dimerization interface [polypeptide binding]; other site 1116391017585 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391017586 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391017587 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391017588 Cache domain; Region: Cache_1; pfam02743 1116391017589 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391017590 dimerization interface [polypeptide binding]; other site 1116391017591 Histidine kinase; Region: His_kinase; pfam06580 1116391017592 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391017593 ATP binding site [chemical binding]; other site 1116391017594 Mg2+ binding site [ion binding]; other site 1116391017595 G-X-G motif; other site 1116391017596 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1116391017597 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1116391017598 ligand binding site [chemical binding]; other site 1116391017599 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1116391017600 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1116391017601 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391017602 putative DNA binding site [nucleotide binding]; other site 1116391017603 putative Zn2+ binding site [ion binding]; other site 1116391017604 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1116391017605 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391017606 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1116391017607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391017608 homodimer interface [polypeptide binding]; other site 1116391017609 catalytic residue [active] 1116391017610 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1116391017611 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391017612 NAD(P) binding site [chemical binding]; other site 1116391017613 active site 1116391017614 Helix-turn-helix domain; Region: HTH_31; pfam13560 1116391017615 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391017616 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391017617 S-layer homology domain; Region: SLH; pfam00395 1116391017618 S-layer homology domain; Region: SLH; pfam00395 1116391017619 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1116391017620 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1116391017621 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391017622 MarR family; Region: MarR; pfam01047 1116391017623 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391017624 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391017625 putative substrate translocation pore; other site 1116391017626 HTH-like domain; Region: HTH_21; pfam13276 1116391017627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391017628 Integrase core domain; Region: rve; pfam00665 1116391017629 Integrase core domain; Region: rve_3; pfam13683 1116391017630 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391017631 Transposase; Region: HTH_Tnp_1; cl17663 1116391017632 helicase 45; Provisional; Region: PTZ00424 1116391017633 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1116391017634 ATP binding site [chemical binding]; other site 1116391017635 Mg++ binding site [ion binding]; other site 1116391017636 motif III; other site 1116391017637 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1116391017638 nucleotide binding region [chemical binding]; other site 1116391017639 ATP-binding site [chemical binding]; other site 1116391017640 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1116391017641 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1116391017642 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1116391017643 active site 1116391017644 HIGH motif; other site 1116391017645 nucleotide binding site [chemical binding]; other site 1116391017646 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1116391017647 active site 1116391017648 KMSKS motif; other site 1116391017649 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1116391017650 tRNA binding surface [nucleotide binding]; other site 1116391017651 anticodon binding site; other site 1116391017652 Ferredoxin [Energy production and conversion]; Region: COG1146 1116391017653 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1116391017654 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1116391017655 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1116391017656 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1116391017657 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391017658 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 1116391017659 D1, D2 subunits of photosystem II (PSII); M, L subunits of bacterial photosynthetic reaction center; Region: Photo_RC; cl08220 1116391017660 Spore germination protein; Region: Spore_permease; cl17796 1116391017661 Helix-turn-helix domain; Region: HTH_18; pfam12833 1116391017662 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391017663 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1116391017664 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1116391017665 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 1116391017666 D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942 1116391017667 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391017668 active site 1116391017669 motif I; other site 1116391017670 motif II; other site 1116391017671 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1116391017672 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391017673 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1116391017674 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1116391017675 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1116391017676 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1116391017677 Catalytic site [active] 1116391017678 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1116391017679 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 1116391017680 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391017681 putative active site [active] 1116391017682 putative metal binding site [ion binding]; other site 1116391017683 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391017684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391017685 Spore germination protein; Region: Spore_permease; cl17796 1116391017686 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391017687 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391017688 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391017689 TSCPD domain; Region: TSCPD; pfam12637 1116391017690 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391017691 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1116391017692 MOSC domain; Region: MOSC; pfam03473 1116391017693 3-alpha domain; Region: 3-alpha; pfam03475 1116391017694 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 1116391017695 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1116391017696 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1116391017697 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 1116391017698 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1116391017699 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391017700 NAD(P) binding site [chemical binding]; other site 1116391017701 active site 1116391017702 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1116391017703 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1116391017704 VanW like protein; Region: VanW; pfam04294 1116391017705 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 1116391017706 nudix motif; other site 1116391017707 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1116391017708 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1116391017709 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1116391017710 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1116391017711 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391017712 Walker A/P-loop; other site 1116391017713 ATP binding site [chemical binding]; other site 1116391017714 Q-loop/lid; other site 1116391017715 ABC transporter signature motif; other site 1116391017716 Walker B; other site 1116391017717 D-loop; other site 1116391017718 H-loop/switch region; other site 1116391017719 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391017720 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 1116391017721 serpin-like protein; Provisional; Region: PHA02660 1116391017722 reactive center loop; other site 1116391017723 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 1116391017724 serpin-like protein; Provisional; Region: PHA02660 1116391017725 reactive center loop; other site 1116391017726 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1116391017727 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 1116391017728 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391017729 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391017730 active site 1116391017731 phosphorylation site [posttranslational modification] 1116391017732 intermolecular recognition site; other site 1116391017733 dimerization interface [polypeptide binding]; other site 1116391017734 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391017735 DNA binding site [nucleotide binding] 1116391017736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391017737 dimerization interface [polypeptide binding]; other site 1116391017738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391017739 dimer interface [polypeptide binding]; other site 1116391017740 phosphorylation site [posttranslational modification] 1116391017741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391017742 ATP binding site [chemical binding]; other site 1116391017743 Mg2+ binding site [ion binding]; other site 1116391017744 G-X-G motif; other site 1116391017745 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1116391017746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391017747 active site 1116391017748 motif I; other site 1116391017749 motif II; other site 1116391017750 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391017751 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1116391017752 active site 1116391017753 DinB superfamily; Region: DinB_2; pfam12867 1116391017754 metal-dependent hydrolase; Provisional; Region: PRK13291 1116391017755 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1116391017756 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1116391017757 DNA binding residues [nucleotide binding] 1116391017758 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1116391017759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391017760 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391017761 putative substrate translocation pore; other site 1116391017762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391017763 Predicted transcriptional regulators [Transcription]; Region: COG1695 1116391017764 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1116391017765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391017766 putative substrate translocation pore; other site 1116391017767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391017768 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391017769 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391017770 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391017771 dimerization interface [polypeptide binding]; other site 1116391017772 histidinol-phosphatase; Provisional; Region: PRK07328 1116391017773 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1116391017774 active site 1116391017775 dimer interface [polypeptide binding]; other site 1116391017776 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1116391017777 active site 1116391017778 catalytic triad [active] 1116391017779 oxyanion hole [active] 1116391017780 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1116391017781 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1116391017782 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1116391017783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391017784 active site 1116391017785 phosphorylation site [posttranslational modification] 1116391017786 intermolecular recognition site; other site 1116391017787 dimerization interface [polypeptide binding]; other site 1116391017788 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391017789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391017790 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391017791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391017792 dimerization interface [polypeptide binding]; other site 1116391017793 Histidine kinase; Region: His_kinase; pfam06580 1116391017794 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391017795 Mg2+ binding site [ion binding]; other site 1116391017796 G-X-G motif; other site 1116391017797 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391017798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391017799 dimer interface [polypeptide binding]; other site 1116391017800 conserved gate region; other site 1116391017801 putative PBP binding loops; other site 1116391017802 ABC-ATPase subunit interface; other site 1116391017803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391017804 dimer interface [polypeptide binding]; other site 1116391017805 conserved gate region; other site 1116391017806 putative PBP binding loops; other site 1116391017807 ABC-ATPase subunit interface; other site 1116391017808 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391017809 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391017810 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1116391017811 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1116391017812 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 1116391017813 active site turn [active] 1116391017814 phosphorylation site [posttranslational modification] 1116391017815 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1116391017816 HPr interaction site; other site 1116391017817 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1116391017818 active site 1116391017819 phosphorylation site [posttranslational modification] 1116391017820 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1116391017821 CAT RNA binding domain; Region: CAT_RBD; smart01061 1116391017822 PRD domain; Region: PRD; pfam00874 1116391017823 PRD domain; Region: PRD; pfam00874 1116391017824 Predicted transcriptional regulators [Transcription]; Region: COG1695 1116391017825 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1116391017826 hypothetical protein; Validated; Region: PRK07668 1116391017827 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1116391017828 active site 1116391017829 catalytic site [active] 1116391017830 substrate binding site [chemical binding]; other site 1116391017831 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391017832 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391017833 S-layer homology domain; Region: SLH; pfam00395 1116391017834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1116391017835 Histidine kinase; Region: HisKA_3; pfam07730 1116391017836 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391017837 ATP binding site [chemical binding]; other site 1116391017838 Mg2+ binding site [ion binding]; other site 1116391017839 G-X-G motif; other site 1116391017840 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391017841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391017842 active site 1116391017843 phosphorylation site [posttranslational modification] 1116391017844 intermolecular recognition site; other site 1116391017845 dimerization interface [polypeptide binding]; other site 1116391017846 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391017847 DNA binding residues [nucleotide binding] 1116391017848 dimerization interface [polypeptide binding]; other site 1116391017849 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391017850 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391017851 Beta-lactamase; Region: Beta-lactamase; pfam00144 1116391017852 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1116391017853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1116391017854 Histidine kinase; Region: HisKA_3; pfam07730 1116391017855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391017856 ATP binding site [chemical binding]; other site 1116391017857 Mg2+ binding site [ion binding]; other site 1116391017858 G-X-G motif; other site 1116391017859 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391017860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391017861 active site 1116391017862 phosphorylation site [posttranslational modification] 1116391017863 intermolecular recognition site; other site 1116391017864 dimerization interface [polypeptide binding]; other site 1116391017865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391017866 DNA binding residues [nucleotide binding] 1116391017867 dimerization interface [polypeptide binding]; other site 1116391017868 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1116391017869 heme-binding site [chemical binding]; other site 1116391017870 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391017871 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391017872 dimer interface [polypeptide binding]; other site 1116391017873 putative CheW interface [polypeptide binding]; other site 1116391017874 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391017875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391017876 active site 1116391017877 phosphorylation site [posttranslational modification] 1116391017878 intermolecular recognition site; other site 1116391017879 dimerization interface [polypeptide binding]; other site 1116391017880 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391017881 DNA binding site [nucleotide binding] 1116391017882 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1116391017883 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391017884 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391017885 dimer interface [polypeptide binding]; other site 1116391017886 phosphorylation site [posttranslational modification] 1116391017887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391017888 ATP binding site [chemical binding]; other site 1116391017889 Mg2+ binding site [ion binding]; other site 1116391017890 G-X-G motif; other site 1116391017891 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1116391017892 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1116391017893 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1116391017894 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391017895 S-adenosylmethionine binding site [chemical binding]; other site 1116391017896 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1116391017897 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391017898 putative active site [active] 1116391017899 heme pocket [chemical binding]; other site 1116391017900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391017901 dimer interface [polypeptide binding]; other site 1116391017902 phosphorylation site [posttranslational modification] 1116391017903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391017904 ATP binding site [chemical binding]; other site 1116391017905 Mg2+ binding site [ion binding]; other site 1116391017906 G-X-G motif; other site 1116391017907 UDP-glucose 4-epimerase; Region: PLN02240 1116391017908 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1116391017909 NAD binding site [chemical binding]; other site 1116391017910 homodimer interface [polypeptide binding]; other site 1116391017911 active site 1116391017912 substrate binding site [chemical binding]; other site 1116391017913 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1116391017914 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1116391017915 Protein of unknown function (DUF466); Region: DUF466; pfam04328 1116391017916 carbon starvation protein A; Provisional; Region: PRK15015 1116391017917 Carbon starvation protein CstA; Region: CstA; pfam02554 1116391017918 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1116391017919 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1116391017920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391017921 active site 1116391017922 phosphorylation site [posttranslational modification] 1116391017923 intermolecular recognition site; other site 1116391017924 dimerization interface [polypeptide binding]; other site 1116391017925 LytTr DNA-binding domain; Region: LytTR; smart00850 1116391017926 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1116391017927 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1116391017928 Histidine kinase; Region: His_kinase; pfam06580 1116391017929 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391017930 ATP binding site [chemical binding]; other site 1116391017931 Mg2+ binding site [ion binding]; other site 1116391017932 G-X-G motif; other site 1116391017933 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1116391017934 active site 1116391017935 metal binding site [ion binding]; metal-binding site 1116391017936 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1116391017937 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 1116391017938 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1116391017939 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1116391017940 putative active site [active] 1116391017941 putative metal binding site [ion binding]; other site 1116391017942 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1116391017943 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391017944 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391017945 putative substrate translocation pore; other site 1116391017946 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391017947 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391017948 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391017949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391017950 dimer interface [polypeptide binding]; other site 1116391017951 conserved gate region; other site 1116391017952 putative PBP binding loops; other site 1116391017953 ABC-ATPase subunit interface; other site 1116391017954 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1116391017955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391017956 dimer interface [polypeptide binding]; other site 1116391017957 conserved gate region; other site 1116391017958 putative PBP binding loops; other site 1116391017959 ABC-ATPase subunit interface; other site 1116391017960 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391017961 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391017962 dimerization interface [polypeptide binding]; other site 1116391017963 Histidine kinase; Region: His_kinase; pfam06580 1116391017964 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391017965 ATP binding site [chemical binding]; other site 1116391017966 Mg2+ binding site [ion binding]; other site 1116391017967 G-X-G motif; other site 1116391017968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391017969 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391017970 active site 1116391017971 phosphorylation site [posttranslational modification] 1116391017972 intermolecular recognition site; other site 1116391017973 dimerization interface [polypeptide binding]; other site 1116391017974 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391017975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391017976 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391017977 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1116391017978 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1116391017979 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1116391017980 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1116391017981 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1116391017982 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1116391017983 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391017984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391017985 active site 1116391017986 phosphorylation site [posttranslational modification] 1116391017987 intermolecular recognition site; other site 1116391017988 dimerization interface [polypeptide binding]; other site 1116391017989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391017990 DNA binding site [nucleotide binding] 1116391017991 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1116391017992 homodimer interface [polypeptide binding]; other site 1116391017993 substrate-cofactor binding pocket; other site 1116391017994 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391017995 catalytic residue [active] 1116391017996 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1116391017997 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1116391017998 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1116391017999 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1116391018000 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391018001 non-specific DNA binding site [nucleotide binding]; other site 1116391018002 salt bridge; other site 1116391018003 sequence-specific DNA binding site [nucleotide binding]; other site 1116391018004 Anti-repressor SinI; Region: SinI; pfam08671 1116391018005 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1116391018006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391018007 non-specific DNA binding site [nucleotide binding]; other site 1116391018008 salt bridge; other site 1116391018009 sequence-specific DNA binding site [nucleotide binding]; other site 1116391018010 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1116391018011 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1116391018012 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1116391018013 Right handed beta helix region; Region: Beta_helix; pfam13229 1116391018014 Kelch motif; Region: Kelch_1; pfam01344 1116391018015 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1116391018016 Kelch domain; Region: Kelch; smart00612 1116391018017 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 1116391018018 Kelch domain; Region: Kelch; smart00612 1116391018019 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1116391018020 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1116391018021 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1116391018022 trimer interface [polypeptide binding]; other site 1116391018023 active site 1116391018024 substrate binding site [chemical binding]; other site 1116391018025 CoA binding site [chemical binding]; other site 1116391018026 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1116391018027 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1116391018028 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1116391018029 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1116391018030 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1116391018031 Right handed beta helix region; Region: Beta_helix; pfam13229 1116391018032 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1116391018033 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1116391018034 active site 1116391018035 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1116391018036 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1116391018037 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1116391018038 active site 1116391018039 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1116391018040 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1116391018041 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1116391018042 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1116391018043 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1116391018044 Glycosyl transferase 4-like domain; Region: Glyco_trans_4_4; cl17183 1116391018045 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391018046 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1116391018047 WzyE protein; Region: WzyE; cl11643 1116391018048 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1116391018049 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1116391018050 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1116391018051 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 1116391018052 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1116391018053 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1116391018054 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1116391018055 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1116391018056 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1116391018057 active site 1116391018058 tetramer interface; other site 1116391018059 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1116391018060 Chain length determinant protein; Region: Wzz; cl15801 1116391018061 putative glycosyl transferase; Provisional; Region: PRK10307 1116391018062 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1116391018063 putative acyl transferase; Provisional; Region: PRK10502 1116391018064 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1116391018065 putative trimer interface [polypeptide binding]; other site 1116391018066 putative active site [active] 1116391018067 putative substrate binding site [chemical binding]; other site 1116391018068 putative CoA binding site [chemical binding]; other site 1116391018069 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391018070 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1116391018071 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1116391018072 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391018073 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391018074 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1116391018075 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1116391018076 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1116391018077 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1116391018078 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1116391018079 NADP-binding site; other site 1116391018080 homotetramer interface [polypeptide binding]; other site 1116391018081 substrate binding site [chemical binding]; other site 1116391018082 homodimer interface [polypeptide binding]; other site 1116391018083 active site 1116391018084 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1116391018085 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1116391018086 NADP binding site [chemical binding]; other site 1116391018087 active site 1116391018088 putative substrate binding site [chemical binding]; other site 1116391018089 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1116391018090 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1116391018091 active site 1116391018092 tetramer interface; other site 1116391018093 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1116391018094 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1116391018095 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1116391018096 Chain length determinant protein; Region: Wzz; cl15801 1116391018097 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1116391018098 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1116391018099 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391018100 sequence-specific DNA binding site [nucleotide binding]; other site 1116391018101 salt bridge; other site 1116391018102 glutamine synthetase, type I; Region: GlnA; TIGR00653 1116391018103 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1116391018104 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1116391018105 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1116391018106 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1116391018107 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 1116391018108 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1116391018109 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1116391018110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391018111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391018112 dimerization interface [polypeptide binding]; other site 1116391018113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391018114 dimer interface [polypeptide binding]; other site 1116391018115 phosphorylation site [posttranslational modification] 1116391018116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391018117 ATP binding site [chemical binding]; other site 1116391018118 Mg2+ binding site [ion binding]; other site 1116391018119 G-X-G motif; other site 1116391018120 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391018121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391018122 active site 1116391018123 phosphorylation site [posttranslational modification] 1116391018124 intermolecular recognition site; other site 1116391018125 dimerization interface [polypeptide binding]; other site 1116391018126 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391018127 DNA binding site [nucleotide binding] 1116391018128 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1116391018129 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1116391018130 protein binding site [polypeptide binding]; other site 1116391018131 YugN-like family; Region: YugN; pfam08868 1116391018132 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1116391018133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1116391018134 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1116391018135 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1116391018136 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1116391018137 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1116391018138 active site 1116391018139 dimer interface [polypeptide binding]; other site 1116391018140 motif 1; other site 1116391018141 motif 2; other site 1116391018142 motif 3; other site 1116391018143 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1116391018144 anticodon binding site; other site 1116391018145 YtxC-like family; Region: YtxC; pfam08812 1116391018146 Predicted membrane protein [Function unknown]; Region: COG3371 1116391018147 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391018148 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391018149 metal binding site [ion binding]; metal-binding site 1116391018150 active site 1116391018151 I-site; other site 1116391018152 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1116391018153 binding surface 1116391018154 TPR motif; other site 1116391018155 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1116391018156 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1116391018157 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391018158 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1116391018159 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 1116391018160 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391018161 FeS/SAM binding site; other site 1116391018162 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 1116391018163 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1116391018164 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1116391018165 homodimer interface [polypeptide binding]; other site 1116391018166 substrate-cofactor binding pocket; other site 1116391018167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391018168 catalytic residue [active] 1116391018169 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1116391018170 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1116391018171 proposed active site lysine [active] 1116391018172 conserved cys residue [active] 1116391018173 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1116391018174 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1116391018175 oligomer interface [polypeptide binding]; other site 1116391018176 metal binding site [ion binding]; metal-binding site 1116391018177 metal binding site [ion binding]; metal-binding site 1116391018178 putative Cl binding site [ion binding]; other site 1116391018179 aspartate ring; other site 1116391018180 basic sphincter; other site 1116391018181 hydrophobic gate; other site 1116391018182 periplasmic entrance; other site 1116391018183 HRDC domain; Region: HRDC; pfam00570 1116391018184 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1116391018185 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 1116391018186 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1116391018187 Predicted transcriptional regulator [Transcription]; Region: COG4189 1116391018188 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391018189 putative DNA binding site [nucleotide binding]; other site 1116391018190 dimerization interface [polypeptide binding]; other site 1116391018191 putative Zn2+ binding site [ion binding]; other site 1116391018192 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1116391018193 5'-3' exonuclease; Region: 53EXOc; smart00475 1116391018194 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1116391018195 active site 1116391018196 metal binding site 1 [ion binding]; metal-binding site 1116391018197 putative 5' ssDNA interaction site; other site 1116391018198 metal binding site 3; metal-binding site 1116391018199 metal binding site 2 [ion binding]; metal-binding site 1116391018200 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1116391018201 putative DNA binding site [nucleotide binding]; other site 1116391018202 putative metal binding site [ion binding]; other site 1116391018203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391018204 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391018205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391018206 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391018207 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391018208 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391018209 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391018210 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391018211 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391018212 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1116391018213 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391018214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391018215 homodimer interface [polypeptide binding]; other site 1116391018216 catalytic residue [active] 1116391018217 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1116391018218 Peptidase family M50; Region: Peptidase_M50; pfam02163 1116391018219 active site 1116391018220 putative substrate binding region [chemical binding]; other site 1116391018221 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1116391018222 ArsC family; Region: ArsC; pfam03960 1116391018223 putative ArsC-like catalytic residues; other site 1116391018224 putative TRX-like catalytic residues [active] 1116391018225 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1116391018226 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1116391018227 putative active site [active] 1116391018228 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1116391018229 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1116391018230 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1116391018231 active site 1116391018232 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 1116391018233 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1116391018234 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391018235 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391018236 homodimer interface [polypeptide binding]; other site 1116391018237 catalytic residue [active] 1116391018238 cobyric acid synthase; Provisional; Region: PRK00784 1116391018239 Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132 1116391018240 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1116391018241 catalytic triad [active] 1116391018242 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1116391018243 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1116391018244 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 1116391018245 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1116391018246 homotrimer interface [polypeptide binding]; other site 1116391018247 Walker A motif; other site 1116391018248 GTP binding site [chemical binding]; other site 1116391018249 Walker B motif; other site 1116391018250 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1116391018251 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1116391018252 putative dimer interface [polypeptide binding]; other site 1116391018253 active site pocket [active] 1116391018254 putative cataytic base [active] 1116391018255 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1116391018256 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391018257 ABC-ATPase subunit interface; other site 1116391018258 dimer interface [polypeptide binding]; other site 1116391018259 putative PBP binding regions; other site 1116391018260 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1116391018261 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 1116391018262 putative binding site residues; other site 1116391018263 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1116391018264 hypothetical protein; Validated; Region: PRK07682 1116391018265 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391018266 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391018267 homodimer interface [polypeptide binding]; other site 1116391018268 catalytic residue [active] 1116391018269 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1116391018270 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1116391018271 AsnC family; Region: AsnC_trans_reg; pfam01037 1116391018272 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1116391018273 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1116391018274 dimer interface [polypeptide binding]; other site 1116391018275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391018276 catalytic residue [active] 1116391018277 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391018278 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391018279 putative substrate translocation pore; other site 1116391018280 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1116391018281 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1116391018282 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1116391018283 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1116391018284 MutS domain III; Region: MutS_III; pfam05192 1116391018285 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1116391018286 Walker A/P-loop; other site 1116391018287 ATP binding site [chemical binding]; other site 1116391018288 Q-loop/lid; other site 1116391018289 ABC transporter signature motif; other site 1116391018290 Walker B; other site 1116391018291 D-loop; other site 1116391018292 H-loop/switch region; other site 1116391018293 Smr domain; Region: Smr; pfam01713 1116391018294 Membrane protein of unknown function; Region: DUF360; pfam04020 1116391018295 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1116391018296 classical (c) SDRs; Region: SDR_c; cd05233 1116391018297 NAD(P) binding site [chemical binding]; other site 1116391018298 active site 1116391018299 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391018300 DNA-binding site [nucleotide binding]; DNA binding site 1116391018301 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1116391018302 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391018303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391018304 homodimer interface [polypeptide binding]; other site 1116391018305 catalytic residue [active] 1116391018306 Colicin V production protein; Region: Colicin_V; pfam02674 1116391018307 Cell division protein ZapA; Region: ZapA; cl01146 1116391018308 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1116391018309 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1116391018310 putative tRNA-binding site [nucleotide binding]; other site 1116391018311 B3/4 domain; Region: B3_4; pfam03483 1116391018312 tRNA synthetase B5 domain; Region: B5; pfam03484 1116391018313 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1116391018314 dimer interface [polypeptide binding]; other site 1116391018315 motif 1; other site 1116391018316 motif 3; other site 1116391018317 motif 2; other site 1116391018318 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1116391018319 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1116391018320 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1116391018321 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1116391018322 dimer interface [polypeptide binding]; other site 1116391018323 motif 1; other site 1116391018324 active site 1116391018325 motif 2; other site 1116391018326 motif 3; other site 1116391018327 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 1116391018328 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1116391018329 Ferritin-like domain; Region: Ferritin; pfam00210 1116391018330 ferroxidase diiron center [ion binding]; other site 1116391018331 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1116391018332 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1116391018333 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391018334 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391018335 DNA binding residues [nucleotide binding] 1116391018336 SnoaL-like domain; Region: SnoaL_2; pfam12680 1116391018337 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1116391018338 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1116391018339 PAS fold; Region: PAS; pfam00989 1116391018340 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391018341 putative active site [active] 1116391018342 heme pocket [chemical binding]; other site 1116391018343 PAS domain S-box; Region: sensory_box; TIGR00229 1116391018344 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391018345 putative active site [active] 1116391018346 heme pocket [chemical binding]; other site 1116391018347 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391018348 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391018349 metal binding site [ion binding]; metal-binding site 1116391018350 active site 1116391018351 I-site; other site 1116391018352 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1116391018353 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1116391018354 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1116391018355 catalytic triad [active] 1116391018356 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1116391018357 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1116391018358 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1116391018359 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1116391018360 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1116391018361 active site 1116391018362 SAM binding site [chemical binding]; other site 1116391018363 homodimer interface [polypeptide binding]; other site 1116391018364 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1116391018365 active site 1116391018366 SAM binding site [chemical binding]; other site 1116391018367 homodimer interface [polypeptide binding]; other site 1116391018368 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1116391018369 active site 1116391018370 putative homodimer interface [polypeptide binding]; other site 1116391018371 SAM binding site [chemical binding]; other site 1116391018372 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1116391018373 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 1116391018374 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1116391018375 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1116391018376 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1116391018377 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1116391018378 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1116391018379 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1116391018380 putative active site [active] 1116391018381 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1116391018382 putative active site [active] 1116391018383 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1116391018384 active site 1116391018385 SAM binding site [chemical binding]; other site 1116391018386 homodimer interface [polypeptide binding]; other site 1116391018387 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 1116391018388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1116391018389 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391018390 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391018391 active site 1116391018392 catalytic tetrad [active] 1116391018393 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391018394 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391018395 metal binding site [ion binding]; metal-binding site 1116391018396 active site 1116391018397 I-site; other site 1116391018398 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1116391018399 CopC domain; Region: CopC; pfam04234 1116391018400 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 1116391018401 ATP cone domain; Region: ATP-cone; pfam03477 1116391018402 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1116391018403 active site 1116391018404 dimer interface [polypeptide binding]; other site 1116391018405 catalytic residues [active] 1116391018406 effector binding site; other site 1116391018407 R2 peptide binding site; other site 1116391018408 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391018409 Transposase; Region: HTH_Tnp_1; cl17663 1116391018410 HTH-like domain; Region: HTH_21; pfam13276 1116391018411 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391018412 Integrase core domain; Region: rve; pfam00665 1116391018413 Integrase core domain; Region: rve_3; pfam13683 1116391018414 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1116391018415 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1116391018416 dimer interface [polypeptide binding]; other site 1116391018417 putative radical transfer pathway; other site 1116391018418 diiron center [ion binding]; other site 1116391018419 tyrosyl radical; other site 1116391018420 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1116391018421 putative binding surface; other site 1116391018422 active site 1116391018423 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391018424 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391018425 active site 1116391018426 phosphorylation site [posttranslational modification] 1116391018427 intermolecular recognition site; other site 1116391018428 dimerization interface [polypeptide binding]; other site 1116391018429 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391018430 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391018431 metal binding site [ion binding]; metal-binding site 1116391018432 active site 1116391018433 I-site; other site 1116391018434 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391018435 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391018436 active site 1116391018437 phosphorylation site [posttranslational modification] 1116391018438 intermolecular recognition site; other site 1116391018439 dimerization interface [polypeptide binding]; other site 1116391018440 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1116391018441 putative active site pocket [active] 1116391018442 dimerization interface [polypeptide binding]; other site 1116391018443 putative catalytic residue [active] 1116391018444 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 1116391018445 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1116391018446 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 1116391018447 putative active site [active] 1116391018448 Mor transcription activator family; Region: Mor; cl02360 1116391018449 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1116391018450 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1116391018451 Allophanate hydrolase subunit 1; Region: AHS1; smart00796 1116391018452 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1116391018453 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1116391018454 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1116391018455 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1116391018456 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1116391018457 active site 1116391018458 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1116391018459 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1116391018460 active site 1116391018461 metal binding site [ion binding]; metal-binding site 1116391018462 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1116391018463 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 1116391018464 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391018465 substrate binding pocket [chemical binding]; other site 1116391018466 membrane-bound complex binding site; other site 1116391018467 hinge residues; other site 1116391018468 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1116391018469 threonine synthase; Validated; Region: PRK06260 1116391018470 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 1116391018471 homodimer interface [polypeptide binding]; other site 1116391018472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391018473 catalytic residue [active] 1116391018474 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1116391018475 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1116391018476 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1116391018477 dimerization interface [polypeptide binding]; other site 1116391018478 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1116391018479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391018480 dimer interface [polypeptide binding]; other site 1116391018481 conserved gate region; other site 1116391018482 ABC-ATPase subunit interface; other site 1116391018483 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1116391018484 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391018485 dimer interface [polypeptide binding]; other site 1116391018486 conserved gate region; other site 1116391018487 ABC-ATPase subunit interface; other site 1116391018488 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1116391018489 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1116391018490 Walker A/P-loop; other site 1116391018491 ATP binding site [chemical binding]; other site 1116391018492 Q-loop/lid; other site 1116391018493 ABC transporter signature motif; other site 1116391018494 Walker B; other site 1116391018495 D-loop; other site 1116391018496 H-loop/switch region; other site 1116391018497 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1116391018498 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1116391018499 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1116391018500 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1116391018501 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1116391018502 Walker A/P-loop; other site 1116391018503 ATP binding site [chemical binding]; other site 1116391018504 Q-loop/lid; other site 1116391018505 ABC transporter signature motif; other site 1116391018506 Walker B; other site 1116391018507 D-loop; other site 1116391018508 H-loop/switch region; other site 1116391018509 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1116391018510 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1116391018511 active site 1116391018512 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391018513 3D domain; Region: 3D; cl01439 1116391018514 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1116391018515 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1116391018516 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1116391018517 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391018518 putative active site [active] 1116391018519 heme pocket [chemical binding]; other site 1116391018520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391018521 ATP binding site [chemical binding]; other site 1116391018522 Mg2+ binding site [ion binding]; other site 1116391018523 G-X-G motif; other site 1116391018524 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1116391018525 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391018526 active site 1116391018527 phosphorylation site [posttranslational modification] 1116391018528 intermolecular recognition site; other site 1116391018529 dimerization interface [polypeptide binding]; other site 1116391018530 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1116391018531 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1116391018532 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1116391018533 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1116391018534 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1116391018535 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1116391018536 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1116391018537 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391018538 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391018539 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391018540 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391018541 lysine transporter; Provisional; Region: PRK10836 1116391018542 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1116391018543 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1116391018544 Walker A/P-loop; other site 1116391018545 ATP binding site [chemical binding]; other site 1116391018546 Q-loop/lid; other site 1116391018547 ABC transporter signature motif; other site 1116391018548 Walker B; other site 1116391018549 D-loop; other site 1116391018550 H-loop/switch region; other site 1116391018551 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1116391018552 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1116391018553 hypothetical protein; Provisional; Region: PRK06185 1116391018554 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1116391018555 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1116391018556 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1116391018557 catalytic site [active] 1116391018558 PrcB C-terminal; Region: PrcB_C; pfam14343 1116391018559 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1116391018560 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1116391018561 putative ligand binding site [chemical binding]; other site 1116391018562 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1116391018563 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1116391018564 Walker A/P-loop; other site 1116391018565 ATP binding site [chemical binding]; other site 1116391018566 Q-loop/lid; other site 1116391018567 ABC transporter signature motif; other site 1116391018568 Walker B; other site 1116391018569 D-loop; other site 1116391018570 H-loop/switch region; other site 1116391018571 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1116391018572 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391018573 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1116391018574 TM-ABC transporter signature motif; other site 1116391018575 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 1116391018576 putative active site [active] 1116391018577 putative catalytic site [active] 1116391018578 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 1116391018579 PLD-like domain; Region: PLDc_2; pfam13091 1116391018580 putative active site [active] 1116391018581 putative catalytic site [active] 1116391018582 Peptidase family M23; Region: Peptidase_M23; pfam01551 1116391018583 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1116391018584 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1116391018585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391018586 dimer interface [polypeptide binding]; other site 1116391018587 conserved gate region; other site 1116391018588 putative PBP binding loops; other site 1116391018589 ABC-ATPase subunit interface; other site 1116391018590 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1116391018591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391018592 dimer interface [polypeptide binding]; other site 1116391018593 conserved gate region; other site 1116391018594 putative PBP binding loops; other site 1116391018595 ABC-ATPase subunit interface; other site 1116391018596 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1116391018597 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391018598 substrate binding pocket [chemical binding]; other site 1116391018599 membrane-bound complex binding site; other site 1116391018600 hinge residues; other site 1116391018601 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1116391018602 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1116391018603 Walker A/P-loop; other site 1116391018604 ATP binding site [chemical binding]; other site 1116391018605 Q-loop/lid; other site 1116391018606 ABC transporter signature motif; other site 1116391018607 Walker B; other site 1116391018608 D-loop; other site 1116391018609 H-loop/switch region; other site 1116391018610 S-layer homology domain; Region: SLH; pfam00395 1116391018611 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 1116391018612 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1116391018613 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1116391018614 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1116391018615 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 1116391018616 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1116391018617 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 1116391018618 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1116391018619 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391018620 putative active site [active] 1116391018621 heme pocket [chemical binding]; other site 1116391018622 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391018623 dimer interface [polypeptide binding]; other site 1116391018624 phosphorylation site [posttranslational modification] 1116391018625 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391018626 ATP binding site [chemical binding]; other site 1116391018627 Mg2+ binding site [ion binding]; other site 1116391018628 G-X-G motif; other site 1116391018629 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 1116391018630 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1116391018631 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1116391018632 active site 1116391018633 zinc binding site [ion binding]; other site 1116391018634 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391018635 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1116391018636 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391018637 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1116391018638 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391018639 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391018640 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391018641 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391018642 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391018643 dimer interface [polypeptide binding]; other site 1116391018644 conserved gate region; other site 1116391018645 putative PBP binding loops; other site 1116391018646 ABC-ATPase subunit interface; other site 1116391018647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391018648 dimer interface [polypeptide binding]; other site 1116391018649 conserved gate region; other site 1116391018650 putative PBP binding loops; other site 1116391018651 ABC-ATPase subunit interface; other site 1116391018652 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391018653 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391018654 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391018655 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391018656 active site 1116391018657 phosphorylation site [posttranslational modification] 1116391018658 intermolecular recognition site; other site 1116391018659 dimerization interface [polypeptide binding]; other site 1116391018660 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391018661 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391018662 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391018663 Histidine kinase; Region: His_kinase; pfam06580 1116391018664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391018665 ATP binding site [chemical binding]; other site 1116391018666 Mg2+ binding site [ion binding]; other site 1116391018667 G-X-G motif; other site 1116391018668 YheO-like PAS domain; Region: PAS_6; pfam08348 1116391018669 HTH domain; Region: HTH_22; pfam13309 1116391018670 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 1116391018671 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1116391018672 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1116391018673 catalytic residue [active] 1116391018674 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 1116391018675 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 1116391018676 active site 1116391018677 putative substrate binding pocket [chemical binding]; other site 1116391018678 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1116391018679 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 1116391018680 homotrimer interaction site [polypeptide binding]; other site 1116391018681 putative active site [active] 1116391018682 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391018683 Coenzyme A binding pocket [chemical binding]; other site 1116391018684 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1116391018685 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1116391018686 Phosphotransferase enzyme family; Region: APH; pfam01636 1116391018687 substrate binding site [chemical binding]; other site 1116391018688 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1116391018689 Phosphotransferase enzyme family; Region: APH; pfam01636 1116391018690 active site 1116391018691 substrate binding site [chemical binding]; other site 1116391018692 ATP binding site [chemical binding]; other site 1116391018693 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1116391018694 putative active site [active] 1116391018695 putative metal binding site [ion binding]; other site 1116391018696 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1116391018697 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1116391018698 FAD binding domain; Region: FAD_binding_3; pfam01494 1116391018699 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1116391018700 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1116391018701 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391018702 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1116391018703 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1116391018704 active site 1116391018705 non-prolyl cis peptide bond; other site 1116391018706 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1116391018707 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1116391018708 Walker A/P-loop; other site 1116391018709 ATP binding site [chemical binding]; other site 1116391018710 Q-loop/lid; other site 1116391018711 ABC transporter signature motif; other site 1116391018712 Walker B; other site 1116391018713 D-loop; other site 1116391018714 H-loop/switch region; other site 1116391018715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1116391018716 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1116391018717 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1116391018718 dimer interface [polypeptide binding]; other site 1116391018719 FMN binding site [chemical binding]; other site 1116391018720 NADPH bind site [chemical binding]; other site 1116391018721 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1116391018722 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1116391018723 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1116391018724 active site 1116391018725 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1116391018726 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1116391018727 Fn3 associated; Region: Fn3_assoc; pfam13287 1116391018728 Fn3 associated; Region: Fn3_assoc; pfam13287 1116391018729 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1116391018730 Fn3 associated; Region: Fn3_assoc; pfam13287 1116391018731 Fn3 associated; Region: Fn3_assoc; pfam13287 1116391018732 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391018733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391018734 active site 1116391018735 phosphorylation site [posttranslational modification] 1116391018736 intermolecular recognition site; other site 1116391018737 dimerization interface [polypeptide binding]; other site 1116391018738 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391018739 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391018740 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391018741 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391018742 dimerization interface [polypeptide binding]; other site 1116391018743 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391018744 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391018745 dimer interface [polypeptide binding]; other site 1116391018746 putative CheW interface [polypeptide binding]; other site 1116391018747 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1116391018748 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391018749 TM-ABC transporter signature motif; other site 1116391018750 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1116391018751 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1116391018752 Walker A/P-loop; other site 1116391018753 ATP binding site [chemical binding]; other site 1116391018754 Q-loop/lid; other site 1116391018755 ABC transporter signature motif; other site 1116391018756 Walker B; other site 1116391018757 D-loop; other site 1116391018758 H-loop/switch region; other site 1116391018759 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1116391018760 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1116391018761 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1116391018762 ligand binding site [chemical binding]; other site 1116391018763 calcium binding site [ion binding]; other site 1116391018764 putative transposase OrfB; Reviewed; Region: PHA02517 1116391018765 HTH-like domain; Region: HTH_21; pfam13276 1116391018766 Integrase core domain; Region: rve; pfam00665 1116391018767 Integrase core domain; Region: rve_3; pfam13683 1116391018768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391018769 Transposase; Region: HTH_Tnp_1; cl17663 1116391018770 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1116391018771 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1116391018772 putative ligand binding site [chemical binding]; other site 1116391018773 Cache domain; Region: Cache_1; pfam02743 1116391018774 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391018775 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391018776 dimerization interface [polypeptide binding]; other site 1116391018777 Histidine kinase; Region: His_kinase; pfam06580 1116391018778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391018779 ATP binding site [chemical binding]; other site 1116391018780 Mg2+ binding site [ion binding]; other site 1116391018781 G-X-G motif; other site 1116391018782 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391018783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391018784 active site 1116391018785 phosphorylation site [posttranslational modification] 1116391018786 intermolecular recognition site; other site 1116391018787 dimerization interface [polypeptide binding]; other site 1116391018788 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391018789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391018790 TIGR02452 family protein; Region: TIGR02452 1116391018791 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 1116391018792 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1116391018793 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1116391018794 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1116391018795 active site 1116391018796 nucleotide binding site [chemical binding]; other site 1116391018797 HIGH motif; other site 1116391018798 KMSKS motif; other site 1116391018799 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1116391018800 Nicotinamide mononucleotide transporter; Region: NMN_transporter; cl01256 1116391018801 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1116391018802 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1116391018803 Leucine rich repeat; Region: LRR_8; pfam13855 1116391018804 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391018805 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1116391018806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391018807 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1116391018808 Walker A motif; other site 1116391018809 ATP binding site [chemical binding]; other site 1116391018810 Walker B motif; other site 1116391018811 arginine finger; other site 1116391018812 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1116391018813 tellurium resistance terB-like protein; Region: terB_like; cd07177 1116391018814 metal binding site [ion binding]; metal-binding site 1116391018815 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1116391018816 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 1116391018817 CGNR zinc finger; Region: zf-CGNR; pfam11706 1116391018818 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1116391018819 phosphate binding site [ion binding]; other site 1116391018820 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1116391018821 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1116391018822 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1116391018823 DNA binding residues [nucleotide binding] 1116391018824 Predicted transcriptional regulators [Transcription]; Region: COG1695 1116391018825 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1116391018826 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1116391018827 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1116391018828 Heat induced stress protein YflT; Region: YflT; pfam11181 1116391018829 conserved domain; Region: TIGR02271 1116391018830 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1116391018831 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1116391018832 protein binding site [polypeptide binding]; other site 1116391018833 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1116391018834 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391018835 ABC-ATPase subunit interface; other site 1116391018836 dimer interface [polypeptide binding]; other site 1116391018837 putative PBP binding regions; other site 1116391018838 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1116391018839 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391018840 ABC-ATPase subunit interface; other site 1116391018841 dimer interface [polypeptide binding]; other site 1116391018842 putative PBP binding regions; other site 1116391018843 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1116391018844 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1116391018845 intersubunit interface [polypeptide binding]; other site 1116391018846 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391018847 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391018848 metal binding site [ion binding]; metal-binding site 1116391018849 active site 1116391018850 I-site; other site 1116391018851 Fic family protein [Function unknown]; Region: COG3177 1116391018852 Fic/DOC family; Region: Fic; pfam02661 1116391018853 MarR family; Region: MarR_2; cl17246 1116391018854 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 1116391018855 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1116391018856 P loop; other site 1116391018857 Nucleotide binding site [chemical binding]; other site 1116391018858 DTAP/Switch II; other site 1116391018859 Switch I; other site 1116391018860 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1116391018861 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1116391018862 Chorismate mutase type II; Region: CM_2; cl00693 1116391018863 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1116391018864 probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620 1116391018865 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 1116391018866 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1116391018867 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391018868 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391018869 active site 1116391018870 catalytic tetrad [active] 1116391018871 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391018872 Coenzyme A binding pocket [chemical binding]; other site 1116391018873 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391018874 Coenzyme A binding pocket [chemical binding]; other site 1116391018875 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1116391018876 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1116391018877 dimer interface [polypeptide binding]; other site 1116391018878 active site 1116391018879 metal binding site [ion binding]; metal-binding site 1116391018880 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 1116391018881 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 1116391018882 substrate binding site; other site 1116391018883 dimerization interface; other site 1116391018884 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391018885 Coenzyme A binding pocket [chemical binding]; other site 1116391018886 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1116391018887 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1116391018888 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1116391018889 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391018890 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1116391018891 substrate binding site [chemical binding]; other site 1116391018892 Mrr N-terminal domain; Region: Mrr_N; pfam14338 1116391018893 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1116391018894 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1116391018895 Competence protein J (ComJ); Region: ComJ; pfam11033 1116391018896 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391018897 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 1116391018898 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391018899 Interdomain contacts; other site 1116391018900 Cytokine receptor motif; other site 1116391018901 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391018902 Interdomain contacts; other site 1116391018903 Cytokine receptor motif; other site 1116391018904 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 1116391018905 dockerin binding interface; other site 1116391018906 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271 1116391018907 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1116391018908 putative NAD(P) binding site [chemical binding]; other site 1116391018909 substrate binding site [chemical binding]; other site 1116391018910 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1116391018911 iron-sulfur cluster [ion binding]; other site 1116391018912 [2Fe-2S] cluster binding site [ion binding]; other site 1116391018913 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1116391018914 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 1116391018915 conserved cys residue [active] 1116391018916 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391018917 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1116391018918 Metal-binding active site; metal-binding site 1116391018919 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1116391018920 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391018921 acyl carrier protein; Provisional; Region: PRK07639 1116391018922 acyl-CoA synthetase; Validated; Region: PRK08308 1116391018923 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1116391018924 acyl-activating enzyme (AAE) consensus motif; other site 1116391018925 AMP binding site [chemical binding]; other site 1116391018926 active site 1116391018927 CoA binding site [chemical binding]; other site 1116391018928 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1116391018929 IucA / IucC family; Region: IucA_IucC; pfam04183 1116391018930 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1116391018931 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391018932 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 1116391018933 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1116391018934 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1116391018935 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 1116391018936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1116391018937 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 1116391018938 IucA / IucC family; Region: IucA_IucC; pfam04183 1116391018939 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1116391018940 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1116391018941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391018942 catalytic residue [active] 1116391018943 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 1116391018944 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1116391018945 inhibitor-cofactor binding pocket; inhibition site 1116391018946 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391018947 catalytic residue [active] 1116391018948 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1116391018949 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1116391018950 siderophore binding site; other site 1116391018951 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1116391018952 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1116391018953 Walker A/P-loop; other site 1116391018954 ATP binding site [chemical binding]; other site 1116391018955 Q-loop/lid; other site 1116391018956 ABC transporter signature motif; other site 1116391018957 Walker B; other site 1116391018958 D-loop; other site 1116391018959 H-loop/switch region; other site 1116391018960 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1116391018961 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391018962 DNA-binding site [nucleotide binding]; DNA binding site 1116391018963 UTRA domain; Region: UTRA; pfam07702 1116391018964 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1116391018965 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1116391018966 substrate binding site [chemical binding]; other site 1116391018967 ATP binding site [chemical binding]; other site 1116391018968 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1116391018969 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1116391018970 putative active site [active] 1116391018971 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1116391018972 fructoselysine 3-epimerase; Provisional; Region: PRK09856 1116391018973 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1116391018974 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 1116391018975 oligomer interface [polypeptide binding]; other site 1116391018976 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1116391018977 Protein of unknown function (DUF458); Region: DUF458; pfam04308 1116391018978 NAD-dependent deacetylase; Provisional; Region: PRK00481 1116391018979 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1116391018980 NAD+ binding site [chemical binding]; other site 1116391018981 substrate binding site [chemical binding]; other site 1116391018982 Zn binding site [ion binding]; other site 1116391018983 xylose isomerase; Provisional; Region: PRK05474 1116391018984 xylose isomerase; Region: xylose_isom_A; TIGR02630 1116391018985 DinB superfamily; Region: DinB_2; pfam12867 1116391018986 DinB family; Region: DinB; cl17821 1116391018987 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1116391018988 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1116391018989 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391018990 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391018991 active site 1116391018992 phosphorylation site [posttranslational modification] 1116391018993 intermolecular recognition site; other site 1116391018994 dimerization interface [polypeptide binding]; other site 1116391018995 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391018996 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391018997 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391018998 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1116391018999 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391019000 dimerization interface [polypeptide binding]; other site 1116391019001 Histidine kinase; Region: His_kinase; pfam06580 1116391019002 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391019003 ATP binding site [chemical binding]; other site 1116391019004 Mg2+ binding site [ion binding]; other site 1116391019005 G-X-G motif; other site 1116391019006 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391019007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391019008 dimer interface [polypeptide binding]; other site 1116391019009 conserved gate region; other site 1116391019010 putative PBP binding loops; other site 1116391019011 ABC-ATPase subunit interface; other site 1116391019012 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391019013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391019014 dimer interface [polypeptide binding]; other site 1116391019015 conserved gate region; other site 1116391019016 putative PBP binding loops; other site 1116391019017 ABC-ATPase subunit interface; other site 1116391019018 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391019019 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391019020 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391019021 active site 1116391019022 catalytic tetrad [active] 1116391019023 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1116391019024 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 1116391019025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391019026 dimer interface [polypeptide binding]; other site 1116391019027 conserved gate region; other site 1116391019028 putative PBP binding loops; other site 1116391019029 ABC-ATPase subunit interface; other site 1116391019030 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1116391019031 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391019032 substrate binding pocket [chemical binding]; other site 1116391019033 membrane-bound complex binding site; other site 1116391019034 hinge residues; other site 1116391019035 Nuclease-related domain; Region: NERD; pfam08378 1116391019036 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1116391019037 ATP binding site [chemical binding]; other site 1116391019038 putative Mg++ binding site [ion binding]; other site 1116391019039 Family description; Region: UvrD_C_2; pfam13538 1116391019040 Protein of unknown function (DUF693); Region: DUF693; pfam05113 1116391019041 DNA-sulfur modification-associated; Region: DndB; pfam14072 1116391019042 DGQHR domain; Region: DGQHR; TIGR03187 1116391019043 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1116391019044 GIY-YIG motif/motif A; other site 1116391019045 active site 1116391019046 catalytic site [active] 1116391019047 metal binding site [ion binding]; metal-binding site 1116391019048 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1116391019049 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1116391019050 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1116391019051 Ligand Binding Site [chemical binding]; other site 1116391019052 Protein of unknown function (DUF4007); Region: DUF4007; pfam13182 1116391019053 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391019054 Walker A motif; other site 1116391019055 ATP binding site [chemical binding]; other site 1116391019056 Walker B motif; other site 1116391019057 arginine finger; other site 1116391019058 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1116391019059 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1116391019060 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 1116391019061 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 1116391019062 Proteins of 100 residues with WXG; Region: WXG100; cl02005 1116391019063 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1116391019064 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1116391019065 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1116391019066 DNA interaction; other site 1116391019067 Metal-binding active site; metal-binding site 1116391019068 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1116391019069 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1116391019070 active site 1116391019071 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1116391019072 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1116391019073 putative metal binding site; other site 1116391019074 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1116391019075 active site 1116391019076 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1116391019077 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1116391019078 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1116391019079 TROVE domain; Region: TROVE; pfam05731 1116391019080 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1116391019081 metal ion-dependent adhesion site (MIDAS); other site 1116391019082 WYL domain; Region: WYL; pfam13280 1116391019083 WYL domain; Region: WYL; pfam13280 1116391019084 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1116391019085 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1116391019086 ring oligomerisation interface [polypeptide binding]; other site 1116391019087 ATP/Mg binding site [chemical binding]; other site 1116391019088 stacking interactions; other site 1116391019089 hinge regions; other site 1116391019090 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1116391019091 oligomerisation interface [polypeptide binding]; other site 1116391019092 mobile loop; other site 1116391019093 roof hairpin; other site 1116391019094 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1116391019095 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1116391019096 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1116391019097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391019098 dimer interface [polypeptide binding]; other site 1116391019099 conserved gate region; other site 1116391019100 putative PBP binding loops; other site 1116391019101 ABC-ATPase subunit interface; other site 1116391019102 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1116391019103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391019104 dimer interface [polypeptide binding]; other site 1116391019105 conserved gate region; other site 1116391019106 putative PBP binding loops; other site 1116391019107 ABC-ATPase subunit interface; other site 1116391019108 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1116391019109 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391019110 Walker A/P-loop; other site 1116391019111 ATP binding site [chemical binding]; other site 1116391019112 Q-loop/lid; other site 1116391019113 ABC transporter signature motif; other site 1116391019114 Walker B; other site 1116391019115 D-loop; other site 1116391019116 H-loop/switch region; other site 1116391019117 TOBE domain; Region: TOBE_2; pfam08402 1116391019118 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1116391019119 putative binding site; other site 1116391019120 putative dimer interface [polypeptide binding]; other site 1116391019121 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391019122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391019123 active site 1116391019124 phosphorylation site [posttranslational modification] 1116391019125 intermolecular recognition site; other site 1116391019126 dimerization interface [polypeptide binding]; other site 1116391019127 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391019128 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391019129 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391019130 dimerization interface [polypeptide binding]; other site 1116391019131 Histidine kinase; Region: His_kinase; pfam06580 1116391019132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391019133 ATP binding site [chemical binding]; other site 1116391019134 Mg2+ binding site [ion binding]; other site 1116391019135 G-X-G motif; other site 1116391019136 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391019137 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391019138 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391019139 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1116391019140 Walker A/P-loop; other site 1116391019141 ATP binding site [chemical binding]; other site 1116391019142 Q-loop/lid; other site 1116391019143 ABC transporter signature motif; other site 1116391019144 Walker B; other site 1116391019145 D-loop; other site 1116391019146 H-loop/switch region; other site 1116391019147 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391019148 Transposase; Region: HTH_Tnp_1; cl17663 1116391019149 HTH-like domain; Region: HTH_21; pfam13276 1116391019150 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391019151 Integrase core domain; Region: rve; pfam00665 1116391019152 Integrase core domain; Region: rve_3; pfam13683 1116391019153 LysE type translocator; Region: LysE; cl00565 1116391019154 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1116391019155 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1116391019156 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1116391019157 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1116391019158 active site 1116391019159 dimer interface [polypeptide binding]; other site 1116391019160 motif 1; other site 1116391019161 motif 2; other site 1116391019162 motif 3; other site 1116391019163 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1116391019164 anticodon binding site; other site 1116391019165 amidase; Provisional; Region: PRK06828 1116391019166 Amidase; Region: Amidase; cl11426 1116391019167 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1116391019168 S-layer homology domain; Region: SLH; pfam00395 1116391019169 TraX protein; Region: TraX; cl05434 1116391019170 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 1116391019171 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1116391019172 Subunit I/III interface [polypeptide binding]; other site 1116391019173 Subunit III/IV interface [polypeptide binding]; other site 1116391019174 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1116391019175 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1116391019176 D-pathway; other site 1116391019177 Putative ubiquinol binding site [chemical binding]; other site 1116391019178 Low-spin heme (heme b) binding site [chemical binding]; other site 1116391019179 Putative water exit pathway; other site 1116391019180 Binuclear center (heme o3/CuB) [ion binding]; other site 1116391019181 K-pathway; other site 1116391019182 Putative proton exit pathway; other site 1116391019183 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 1116391019184 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1116391019185 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1116391019186 Pectinesterase; Region: Pectinesterase; pfam01095 1116391019187 putative pectinesterase; Region: PLN02432; cl01911 1116391019188 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1116391019189 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1116391019190 catalytic residues [active] 1116391019191 dimer interface [polypeptide binding]; other site 1116391019192 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1116391019193 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 1116391019194 ligand binding site [chemical binding]; other site 1116391019195 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1116391019196 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391019197 TM-ABC transporter signature motif; other site 1116391019198 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391019199 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1116391019200 TM-ABC transporter signature motif; other site 1116391019201 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1116391019202 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1116391019203 Walker A/P-loop; other site 1116391019204 ATP binding site [chemical binding]; other site 1116391019205 Q-loop/lid; other site 1116391019206 ABC transporter signature motif; other site 1116391019207 Walker B; other site 1116391019208 D-loop; other site 1116391019209 H-loop/switch region; other site 1116391019210 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1116391019211 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1116391019212 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1116391019213 Walker A/P-loop; other site 1116391019214 ATP binding site [chemical binding]; other site 1116391019215 Q-loop/lid; other site 1116391019216 ABC transporter signature motif; other site 1116391019217 Walker B; other site 1116391019218 D-loop; other site 1116391019219 H-loop/switch region; other site 1116391019220 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1116391019221 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1116391019222 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1116391019223 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1116391019224 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1116391019225 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1116391019226 DNA binding residues [nucleotide binding] 1116391019227 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1116391019228 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1116391019229 DNA binding residues [nucleotide binding] 1116391019230 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1116391019231 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1116391019232 Cache domain; Region: Cache_1; pfam02743 1116391019233 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391019234 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391019235 metal binding site [ion binding]; metal-binding site 1116391019236 active site 1116391019237 I-site; other site 1116391019238 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1116391019239 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391019240 putative metal binding site [ion binding]; other site 1116391019241 DoxX; Region: DoxX; pfam07681 1116391019242 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391019243 sequence-specific DNA binding site [nucleotide binding]; other site 1116391019244 salt bridge; other site 1116391019245 Cupin domain; Region: Cupin_2; pfam07883 1116391019246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391019247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391019248 ATP binding site [chemical binding]; other site 1116391019249 Mg2+ binding site [ion binding]; other site 1116391019250 G-X-G motif; other site 1116391019251 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391019252 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 1116391019253 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391019254 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391019255 dimer interface [polypeptide binding]; other site 1116391019256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391019257 ATP binding site [chemical binding]; other site 1116391019258 Mg2+ binding site [ion binding]; other site 1116391019259 G-X-G motif; other site 1116391019260 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1116391019261 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1116391019262 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1116391019263 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1116391019264 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1116391019265 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1116391019266 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1116391019267 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1116391019268 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1116391019269 Walker A motif; other site 1116391019270 ATP binding site [chemical binding]; other site 1116391019271 Walker B motif; other site 1116391019272 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1116391019273 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1116391019274 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1116391019275 Walker A motif; other site 1116391019276 ATP binding site [chemical binding]; other site 1116391019277 Walker B motif; other site 1116391019278 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1116391019279 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1116391019280 Bacterial Ig-like domain 2; Region: BID_2; smart00635 1116391019281 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1116391019282 NAD-dependent deacetylase; Provisional; Region: PRK00481 1116391019283 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 1116391019284 NAD+ binding site [chemical binding]; other site 1116391019285 substrate binding site [chemical binding]; other site 1116391019286 Zn binding site [ion binding]; other site 1116391019287 pullulanase, type I; Region: pulA_typeI; TIGR02104 1116391019288 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1116391019289 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1116391019290 Ca binding site [ion binding]; other site 1116391019291 active site 1116391019292 catalytic site [active] 1116391019293 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1116391019294 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1116391019295 tetramer interface [polypeptide binding]; other site 1116391019296 heme binding pocket [chemical binding]; other site 1116391019297 NADPH binding site [chemical binding]; other site 1116391019298 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391019299 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391019300 active site 1116391019301 phosphorylation site [posttranslational modification] 1116391019302 intermolecular recognition site; other site 1116391019303 dimerization interface [polypeptide binding]; other site 1116391019304 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391019305 DNA binding residues [nucleotide binding] 1116391019306 dimerization interface [polypeptide binding]; other site 1116391019307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1116391019308 TspO/MBR family; Region: TspO_MBR; cl01379 1116391019309 Histidine kinase; Region: HisKA_3; pfam07730 1116391019310 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391019311 ATP binding site [chemical binding]; other site 1116391019312 Mg2+ binding site [ion binding]; other site 1116391019313 G-X-G motif; other site 1116391019314 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1116391019315 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1116391019316 putative di-iron ligands [ion binding]; other site 1116391019317 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1116391019318 active site 1116391019319 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1116391019320 active site 1116391019321 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1116391019322 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1116391019323 putative sugar binding sites [chemical binding]; other site 1116391019324 Q-X-W motif; other site 1116391019325 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1116391019326 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 1116391019327 putative ADP-binding pocket [chemical binding]; other site 1116391019328 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1116391019329 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1116391019330 HEAT repeats; Region: HEAT_2; pfam13646 1116391019331 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1116391019332 nudix motif; other site 1116391019333 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1116391019334 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391019335 S-adenosylmethionine binding site [chemical binding]; other site 1116391019336 putative lipid kinase; Reviewed; Region: PRK13337 1116391019337 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1116391019338 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1116391019339 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1116391019340 putative active site [active] 1116391019341 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1116391019342 putative active site [active] 1116391019343 TrpR-related protein YerC/YecD; Region: yecD_yerC; TIGR02531 1116391019344 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1116391019345 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1116391019346 active site 1116391019347 FMN binding site [chemical binding]; other site 1116391019348 substrate binding site [chemical binding]; other site 1116391019349 homotetramer interface [polypeptide binding]; other site 1116391019350 catalytic residue [active] 1116391019351 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1116391019352 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391019353 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391019354 dimer interface [polypeptide binding]; other site 1116391019355 phosphorylation site [posttranslational modification] 1116391019356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391019357 ATP binding site [chemical binding]; other site 1116391019358 Mg2+ binding site [ion binding]; other site 1116391019359 G-X-G motif; other site 1116391019360 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1116391019361 Cupin domain; Region: Cupin_2; pfam07883 1116391019362 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391019363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391019364 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391019365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391019366 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391019367 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391019368 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391019369 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391019370 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391019371 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 1116391019372 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391019373 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391019374 DNA binding residues [nucleotide binding] 1116391019375 Predicted membrane protein [Function unknown]; Region: COG2261 1116391019376 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391019377 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391019378 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1116391019379 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391019380 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1116391019381 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391019382 DNA binding residues [nucleotide binding] 1116391019383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1116391019384 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1116391019385 ATP binding site [chemical binding]; other site 1116391019386 G-X-G motif; other site 1116391019387 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1116391019388 anti sigma factor interaction site; other site 1116391019389 regulatory phosphorylation site [posttranslational modification]; other site 1116391019390 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1116391019391 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1116391019392 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1116391019393 dimerization interface [polypeptide binding]; other site 1116391019394 DPS ferroxidase diiron center [ion binding]; other site 1116391019395 ion pore; other site 1116391019396 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1116391019397 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1116391019398 ligand binding site [chemical binding]; other site 1116391019399 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1116391019400 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1116391019401 Walker A/P-loop; other site 1116391019402 ATP binding site [chemical binding]; other site 1116391019403 Q-loop/lid; other site 1116391019404 ABC transporter signature motif; other site 1116391019405 Walker B; other site 1116391019406 D-loop; other site 1116391019407 H-loop/switch region; other site 1116391019408 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1116391019409 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1116391019410 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1116391019411 TM-ABC transporter signature motif; other site 1116391019412 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1116391019413 TM-ABC transporter signature motif; other site 1116391019414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1116391019415 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1116391019416 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1116391019417 anti sigma factor interaction site; other site 1116391019418 regulatory phosphorylation site [posttranslational modification]; other site 1116391019419 Heat induced stress protein YflT; Region: YflT; pfam11181 1116391019420 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1116391019421 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1116391019422 ligand binding site; other site 1116391019423 oligomer interface; other site 1116391019424 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1116391019425 N-terminal domain interface [polypeptide binding]; other site 1116391019426 sulfate 1 binding site; other site 1116391019427 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391019428 Interdomain contacts; other site 1116391019429 Cytokine receptor motif; other site 1116391019430 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391019431 Interdomain contacts; other site 1116391019432 Cytokine receptor motif; other site 1116391019433 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 1116391019434 dockerin binding interface; other site 1116391019435 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391019436 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391019437 active site 1116391019438 phosphorylation site [posttranslational modification] 1116391019439 intermolecular recognition site; other site 1116391019440 dimerization interface [polypeptide binding]; other site 1116391019441 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391019442 dimer interface [polypeptide binding]; other site 1116391019443 phosphorylation site [posttranslational modification] 1116391019444 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391019445 ATP binding site [chemical binding]; other site 1116391019446 Mg2+ binding site [ion binding]; other site 1116391019447 G-X-G motif; other site 1116391019448 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1116391019449 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1116391019450 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1116391019451 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1116391019452 dimerization interface [polypeptide binding]; other site 1116391019453 GAF domain; Region: GAF_3; pfam13492 1116391019454 GAF domain; Region: GAF_2; pfam13185 1116391019455 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391019456 dimer interface [polypeptide binding]; other site 1116391019457 phosphorylation site [posttranslational modification] 1116391019458 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391019459 ATP binding site [chemical binding]; other site 1116391019460 Mg2+ binding site [ion binding]; other site 1116391019461 G-X-G motif; other site 1116391019462 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391019463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391019464 active site 1116391019465 phosphorylation site [posttranslational modification] 1116391019466 intermolecular recognition site; other site 1116391019467 dimerization interface [polypeptide binding]; other site 1116391019468 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391019469 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391019470 active site 1116391019471 phosphorylation site [posttranslational modification] 1116391019472 intermolecular recognition site; other site 1116391019473 dimerization interface [polypeptide binding]; other site 1116391019474 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391019475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391019476 active site 1116391019477 phosphorylation site [posttranslational modification] 1116391019478 intermolecular recognition site; other site 1116391019479 dimerization interface [polypeptide binding]; other site 1116391019480 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391019481 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391019482 active site 1116391019483 phosphorylation site [posttranslational modification] 1116391019484 intermolecular recognition site; other site 1116391019485 dimerization interface [polypeptide binding]; other site 1116391019486 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1116391019487 Heat induced stress protein YflT; Region: YflT; pfam11181 1116391019488 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1116391019489 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1116391019490 NodB motif; other site 1116391019491 active site 1116391019492 catalytic site [active] 1116391019493 metal binding site [ion binding]; metal-binding site 1116391019494 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 1116391019495 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391019496 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391019497 DNA binding residues [nucleotide binding] 1116391019498 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1116391019499 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1116391019500 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1116391019501 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1116391019502 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1116391019503 putative active site [active] 1116391019504 metal binding site [ion binding]; metal-binding site 1116391019505 DinB superfamily; Region: DinB_2; pfam12867 1116391019506 Predicted transcriptional regulator [Transcription]; Region: COG2378 1116391019507 HTH domain; Region: HTH_11; pfam08279 1116391019508 WYL domain; Region: WYL; pfam13280 1116391019509 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1116391019510 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1116391019511 catalytic residues [active] 1116391019512 IDEAL domain; Region: IDEAL; cl07452 1116391019513 Predicted transcriptional regulator [Transcription]; Region: COG1959 1116391019514 Transcriptional regulator; Region: Rrf2; pfam02082 1116391019515 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1116391019516 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1116391019517 siderophore binding site; other site 1116391019518 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1116391019519 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391019520 ABC-ATPase subunit interface; other site 1116391019521 dimer interface [polypeptide binding]; other site 1116391019522 putative PBP binding regions; other site 1116391019523 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1116391019524 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391019525 ABC-ATPase subunit interface; other site 1116391019526 dimer interface [polypeptide binding]; other site 1116391019527 putative PBP binding regions; other site 1116391019528 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1116391019529 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1116391019530 Walker A/P-loop; other site 1116391019531 ATP binding site [chemical binding]; other site 1116391019532 Q-loop/lid; other site 1116391019533 ABC transporter signature motif; other site 1116391019534 Walker B; other site 1116391019535 D-loop; other site 1116391019536 H-loop/switch region; other site 1116391019537 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1116391019538 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1116391019539 active site 1116391019540 TDP-binding site; other site 1116391019541 acceptor substrate-binding pocket; other site 1116391019542 homodimer interface [polypeptide binding]; other site 1116391019543 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1116391019544 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1116391019545 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1116391019546 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1116391019547 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 1116391019548 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 1116391019549 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1116391019550 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1116391019551 active site 1116391019552 substrate binding site [chemical binding]; other site 1116391019553 cosubstrate binding site; other site 1116391019554 catalytic site [active] 1116391019555 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1116391019556 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1116391019557 dimerization interface [polypeptide binding]; other site 1116391019558 putative ATP binding site [chemical binding]; other site 1116391019559 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 1116391019560 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1116391019561 active site 1116391019562 tetramer interface [polypeptide binding]; other site 1116391019563 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1116391019564 active site 1116391019565 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1116391019566 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1116391019567 dimerization interface [polypeptide binding]; other site 1116391019568 ATP binding site [chemical binding]; other site 1116391019569 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1116391019570 dimerization interface [polypeptide binding]; other site 1116391019571 ATP binding site [chemical binding]; other site 1116391019572 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1116391019573 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1116391019574 putative active site [active] 1116391019575 catalytic triad [active] 1116391019576 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 1116391019577 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1116391019578 ATP binding site [chemical binding]; other site 1116391019579 active site 1116391019580 substrate binding site [chemical binding]; other site 1116391019581 adenylosuccinate lyase; Provisional; Region: PRK07492 1116391019582 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1116391019583 tetramer interface [polypeptide binding]; other site 1116391019584 active site 1116391019585 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1116391019586 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391019587 3D domain; Region: 3D; cl01439 1116391019588 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1116391019589 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1116391019590 NodB motif; other site 1116391019591 active site 1116391019592 catalytic site [active] 1116391019593 metal binding site [ion binding]; metal-binding site 1116391019594 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 1116391019595 UGMP family protein; Validated; Region: PRK09604 1116391019596 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1116391019597 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1116391019598 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391019599 Coenzyme A binding pocket [chemical binding]; other site 1116391019600 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1116391019601 Glycoprotease family; Region: Peptidase_M22; pfam00814 1116391019602 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1116391019603 thiamine monophosphate kinase; Provisional; Region: PRK05731 1116391019604 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1116391019605 ATP binding site [chemical binding]; other site 1116391019606 dimerization interface [polypeptide binding]; other site 1116391019607 Small acid-soluble spore protein H family; Region: SspH; cl06949 1116391019608 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1116391019609 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1116391019610 putative DNA binding site [nucleotide binding]; other site 1116391019611 putative homodimer interface [polypeptide binding]; other site 1116391019612 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 1116391019613 TrkA-C domain; Region: TrkA_C; pfam02080 1116391019614 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1116391019615 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1116391019616 active site 1116391019617 DNA binding site [nucleotide binding] 1116391019618 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1116391019619 DNA binding site [nucleotide binding] 1116391019620 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1116391019621 nucleotide binding site [chemical binding]; other site 1116391019622 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1116391019623 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1116391019624 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1116391019625 putative active site [active] 1116391019626 catalytic site [active] 1116391019627 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1116391019628 putative active site [active] 1116391019629 catalytic site [active] 1116391019630 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1116391019631 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1116391019632 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1116391019633 Spore germination protein; Region: Spore_permease; cl17796 1116391019634 TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329 1116391019635 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1116391019636 Peptidase family M23; Region: Peptidase_M23; pfam01551 1116391019637 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1116391019638 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1116391019639 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1116391019640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391019641 motif II; other site 1116391019642 aminoglycoside resistance protein; Provisional; Region: PRK13746 1116391019643 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1116391019644 metal binding triad [ion binding]; metal-binding site 1116391019645 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 1116391019646 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1116391019647 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1116391019648 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1116391019649 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1116391019650 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1116391019651 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1116391019652 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391019653 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1116391019654 putative active site [active] 1116391019655 heme pocket [chemical binding]; other site 1116391019656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391019657 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1116391019658 putative active site [active] 1116391019659 heme pocket [chemical binding]; other site 1116391019660 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391019661 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1116391019662 putative active site [active] 1116391019663 heme pocket [chemical binding]; other site 1116391019664 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391019665 phosphorylation site [posttranslational modification] 1116391019666 dimer interface [polypeptide binding]; other site 1116391019667 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391019668 ATP binding site [chemical binding]; other site 1116391019669 Mg2+ binding site [ion binding]; other site 1116391019670 G-X-G motif; other site 1116391019671 thymidine kinase; Provisional; Region: PRK04296 1116391019672 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 1116391019673 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391019674 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391019675 homodimer interface [polypeptide binding]; other site 1116391019676 catalytic residue [active] 1116391019677 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1116391019678 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1116391019679 DNA-binding site [nucleotide binding]; DNA binding site 1116391019680 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1116391019681 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391019682 homodimer interface [polypeptide binding]; other site 1116391019683 catalytic residue [active] 1116391019684 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1116391019685 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391019686 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1116391019687 DNA binding residues [nucleotide binding] 1116391019688 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1116391019689 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 1116391019690 putative active site [active] 1116391019691 putative metal binding site [ion binding]; other site 1116391019692 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1116391019693 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391019694 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1116391019695 putative homodimer interface [polypeptide binding]; other site 1116391019696 putative homotetramer interface [polypeptide binding]; other site 1116391019697 allosteric switch controlling residues; other site 1116391019698 putative metal binding site [ion binding]; other site 1116391019699 putative homodimer-homodimer interface [polypeptide binding]; other site 1116391019700 Uncharacterized conserved protein [Function unknown]; Region: COG3349 1116391019701 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1116391019702 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1116391019703 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1116391019704 proposed catalytic triad [active] 1116391019705 conserved cys residue [active] 1116391019706 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1116391019707 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1116391019708 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391019709 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391019710 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1116391019711 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1116391019712 putative ADP-ribose binding site [chemical binding]; other site 1116391019713 putative active site [active] 1116391019714 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391019715 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391019716 active site 1116391019717 phosphorylation site [posttranslational modification] 1116391019718 intermolecular recognition site; other site 1116391019719 dimerization interface [polypeptide binding]; other site 1116391019720 Coat F domain; Region: Coat_F; pfam07875 1116391019721 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391019722 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391019723 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 1116391019724 CheW-like domain; Region: CheW; pfam01584 1116391019725 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1116391019726 lipoyl attachment site [posttranslational modification]; other site 1116391019727 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1116391019728 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1116391019729 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1116391019730 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1116391019731 tetramer interface [polypeptide binding]; other site 1116391019732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391019733 catalytic residue [active] 1116391019734 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1116391019735 tetramer interface [polypeptide binding]; other site 1116391019736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391019737 catalytic residue [active] 1116391019738 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1116391019739 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 1116391019740 siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951 1116391019741 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1116391019742 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 1116391019743 Lamin Tail Domain; Region: LTD; pfam00932 1116391019744 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1116391019745 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391019746 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391019747 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391019748 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1116391019749 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1116391019750 DNA binding site [nucleotide binding] 1116391019751 domain linker motif; other site 1116391019752 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 1116391019753 putative dimerization interface [polypeptide binding]; other site 1116391019754 putative ligand binding site [chemical binding]; other site 1116391019755 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391019756 Interdomain contacts; other site 1116391019757 Cytokine receptor motif; other site 1116391019758 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391019759 Interdomain contacts; other site 1116391019760 Cytokine receptor motif; other site 1116391019761 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 1116391019762 dockerin binding interface; other site 1116391019763 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1116391019764 Glyco_18 domain; Region: Glyco_18; smart00636 1116391019765 active site 1116391019766 S-layer homology domain; Region: SLH; pfam00395 1116391019767 S-layer homology domain; Region: SLH; pfam00395 1116391019768 S-layer homology domain; Region: SLH; pfam00395 1116391019769 phytoene desaturase; Region: phytoene_desat; TIGR02731 1116391019770 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1116391019771 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1116391019772 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1116391019773 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1116391019774 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1116391019775 oligomer interface [polypeptide binding]; other site 1116391019776 metal binding site [ion binding]; metal-binding site 1116391019777 metal binding site [ion binding]; metal-binding site 1116391019778 putative Cl binding site [ion binding]; other site 1116391019779 aspartate ring; other site 1116391019780 basic sphincter; other site 1116391019781 hydrophobic gate; other site 1116391019782 periplasmic entrance; other site 1116391019783 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1116391019784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1116391019785 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391019786 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391019787 Predicted membrane protein [Function unknown]; Region: COG3326 1116391019788 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1116391019789 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391019790 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391019791 metal binding site [ion binding]; metal-binding site 1116391019792 active site 1116391019793 I-site; other site 1116391019794 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391019795 dimer interface [polypeptide binding]; other site 1116391019796 phosphorylation site [posttranslational modification] 1116391019797 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391019798 ATP binding site [chemical binding]; other site 1116391019799 Mg2+ binding site [ion binding]; other site 1116391019800 G-X-G motif; other site 1116391019801 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391019802 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391019803 active site 1116391019804 phosphorylation site [posttranslational modification] 1116391019805 intermolecular recognition site; other site 1116391019806 dimerization interface [polypeptide binding]; other site 1116391019807 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391019808 DNA binding site [nucleotide binding] 1116391019809 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1116391019810 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391019811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391019812 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391019813 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391019814 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1116391019815 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391019816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391019817 dimer interface [polypeptide binding]; other site 1116391019818 conserved gate region; other site 1116391019819 putative PBP binding loops; other site 1116391019820 ABC-ATPase subunit interface; other site 1116391019821 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391019822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391019823 dimer interface [polypeptide binding]; other site 1116391019824 conserved gate region; other site 1116391019825 ABC-ATPase subunit interface; other site 1116391019826 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 1116391019827 active site 1116391019828 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1116391019829 sugar binding site [chemical binding]; other site 1116391019830 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1116391019831 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1116391019832 NAD(P) binding site [chemical binding]; other site 1116391019833 catalytic residues [active] 1116391019834 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 1116391019835 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1116391019836 inhibitor-cofactor binding pocket; inhibition site 1116391019837 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391019838 catalytic residue [active] 1116391019839 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1116391019840 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1116391019841 inhibitor-cofactor binding pocket; inhibition site 1116391019842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391019843 catalytic residue [active] 1116391019844 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 1116391019845 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 1116391019846 tetramerization interface [polypeptide binding]; other site 1116391019847 NAD(P) binding site [chemical binding]; other site 1116391019848 catalytic residues [active] 1116391019849 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1116391019850 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1116391019851 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1116391019852 NAD(P) binding site [chemical binding]; other site 1116391019853 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 1116391019854 tetramer interface [polypeptide binding]; other site 1116391019855 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1116391019856 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1116391019857 active site 1116391019858 multimer interface [polypeptide binding]; other site 1116391019859 Protein of unknown function (DUF441); Region: DUF441; pfam04284 1116391019860 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391019861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391019862 ATP binding site [chemical binding]; other site 1116391019863 Mg2+ binding site [ion binding]; other site 1116391019864 G-X-G motif; other site 1116391019865 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391019866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391019867 active site 1116391019868 phosphorylation site [posttranslational modification] 1116391019869 intermolecular recognition site; other site 1116391019870 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1116391019871 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1116391019872 carboxyltransferase (CT) interaction site; other site 1116391019873 biotinylation site [posttranslational modification]; other site 1116391019874 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1116391019875 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1116391019876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391019877 putative active site [active] 1116391019878 heme pocket [chemical binding]; other site 1116391019879 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391019880 Walker A motif; other site 1116391019881 ATP binding site [chemical binding]; other site 1116391019882 Walker B motif; other site 1116391019883 arginine finger; other site 1116391019884 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1116391019885 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1116391019886 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1116391019887 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1116391019888 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1116391019889 agmatinase; Region: agmatinase; TIGR01230 1116391019890 oligomer interface [polypeptide binding]; other site 1116391019891 putative active site [active] 1116391019892 Mn binding site [ion binding]; other site 1116391019893 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1116391019894 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1116391019895 HIGH motif; other site 1116391019896 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1116391019897 active site 1116391019898 KMSKS motif; other site 1116391019899 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1116391019900 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391019901 ATP binding site [chemical binding]; other site 1116391019902 Mg2+ binding site [ion binding]; other site 1116391019903 G-X-G motif; other site 1116391019904 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 1116391019905 Amidinotransferase; Region: Amidinotransf; pfam02274 1116391019906 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1116391019907 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1116391019908 active site 1116391019909 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1116391019910 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 1116391019911 catalytic core [active] 1116391019912 EamA-like transporter family; Region: EamA; pfam00892 1116391019913 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1116391019914 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1116391019915 glutaminase active site [active] 1116391019916 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1116391019917 dimer interface [polypeptide binding]; other site 1116391019918 active site 1116391019919 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1116391019920 dimer interface [polypeptide binding]; other site 1116391019921 active site 1116391019922 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1116391019923 YbbR-like protein; Region: YbbR; pfam07949 1116391019924 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1116391019925 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1116391019926 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1116391019927 Putative zinc-finger; Region: zf-HC2; pfam13490 1116391019928 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1116391019929 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1116391019930 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 1116391019931 CHASE3 domain; Region: CHASE3; pfam05227 1116391019932 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391019933 dimerization interface [polypeptide binding]; other site 1116391019934 GAF domain; Region: GAF_2; pfam13185 1116391019935 GAF domain; Region: GAF; pfam01590 1116391019936 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391019937 dimer interface [polypeptide binding]; other site 1116391019938 phosphorylation site [posttranslational modification] 1116391019939 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391019940 ATP binding site [chemical binding]; other site 1116391019941 Mg2+ binding site [ion binding]; other site 1116391019942 G-X-G motif; other site 1116391019943 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391019944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391019945 active site 1116391019946 phosphorylation site [posttranslational modification] 1116391019947 intermolecular recognition site; other site 1116391019948 dimerization interface [polypeptide binding]; other site 1116391019949 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1116391019950 homodimer interface [polypeptide binding]; other site 1116391019951 maltodextrin glucosidase; Provisional; Region: PRK10785 1116391019952 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1116391019953 active site 1116391019954 homodimer interface [polypeptide binding]; other site 1116391019955 catalytic site [active] 1116391019956 Heat induced stress protein YflT; Region: YflT; pfam11181 1116391019957 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1116391019958 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1116391019959 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1116391019960 classical (c) SDRs; Region: SDR_c; cd05233 1116391019961 NAD(P) binding site [chemical binding]; other site 1116391019962 active site 1116391019963 Integral membrane protein DUF95; Region: DUF95; pfam01944 1116391019964 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1116391019965 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1116391019966 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1116391019967 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 1116391019968 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1116391019969 Walker A motif; other site 1116391019970 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1116391019971 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1116391019972 active site 1116391019973 metal binding site [ion binding]; metal-binding site 1116391019974 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1116391019975 ATP-sulfurylase; Region: ATPS; cd00517 1116391019976 active site 1116391019977 HXXH motif; other site 1116391019978 flexible loop; other site 1116391019979 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1116391019980 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1116391019981 Active Sites [active] 1116391019982 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1116391019983 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1116391019984 23S rRNA interface [nucleotide binding]; other site 1116391019985 L3 interface [polypeptide binding]; other site 1116391019986 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1116391019987 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1116391019988 dimerization interface 3.5A [polypeptide binding]; other site 1116391019989 active site 1116391019990 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1116391019991 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1116391019992 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1116391019993 alphaNTD - beta interaction site [polypeptide binding]; other site 1116391019994 alphaNTD homodimer interface [polypeptide binding]; other site 1116391019995 alphaNTD - beta' interaction site [polypeptide binding]; other site 1116391019996 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1116391019997 30S ribosomal protein S11; Validated; Region: PRK05309 1116391019998 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1116391019999 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1116391020000 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1116391020001 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1116391020002 rRNA binding site [nucleotide binding]; other site 1116391020003 predicted 30S ribosome binding site; other site 1116391020004 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 1116391020005 RNA binding site [nucleotide binding]; other site 1116391020006 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1116391020007 active site 1116391020008 adenylate kinase; Reviewed; Region: adk; PRK00279 1116391020009 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1116391020010 AMP-binding site [chemical binding]; other site 1116391020011 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1116391020012 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1116391020013 SecY translocase; Region: SecY; pfam00344 1116391020014 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1116391020015 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1116391020016 23S rRNA binding site [nucleotide binding]; other site 1116391020017 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1116391020018 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1116391020019 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1116391020020 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1116391020021 5S rRNA interface [nucleotide binding]; other site 1116391020022 L27 interface [polypeptide binding]; other site 1116391020023 23S rRNA interface [nucleotide binding]; other site 1116391020024 L5 interface [polypeptide binding]; other site 1116391020025 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1116391020026 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1116391020027 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1116391020028 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1116391020029 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1116391020030 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1116391020031 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1116391020032 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1116391020033 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1116391020034 RNA binding site [nucleotide binding]; other site 1116391020035 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1116391020036 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1116391020037 23S rRNA interface [nucleotide binding]; other site 1116391020038 putative translocon interaction site; other site 1116391020039 signal recognition particle (SRP54) interaction site; other site 1116391020040 L23 interface [polypeptide binding]; other site 1116391020041 trigger factor interaction site; other site 1116391020042 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1116391020043 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1116391020044 G-X-X-G motif; other site 1116391020045 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1116391020046 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1116391020047 putative translocon binding site; other site 1116391020048 protein-rRNA interface [nucleotide binding]; other site 1116391020049 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1116391020050 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1116391020051 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1116391020052 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1116391020053 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1116391020054 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1116391020055 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1116391020056 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1116391020057 elongation factor Tu; Reviewed; Region: PRK00049 1116391020058 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1116391020059 G1 box; other site 1116391020060 GEF interaction site [polypeptide binding]; other site 1116391020061 GTP/Mg2+ binding site [chemical binding]; other site 1116391020062 Switch I region; other site 1116391020063 G2 box; other site 1116391020064 G3 box; other site 1116391020065 Switch II region; other site 1116391020066 G4 box; other site 1116391020067 G5 box; other site 1116391020068 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1116391020069 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1116391020070 Antibiotic Binding Site [chemical binding]; other site 1116391020071 30S ribosomal protein S7; Validated; Region: PRK05302 1116391020072 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1116391020073 S17 interaction site [polypeptide binding]; other site 1116391020074 S8 interaction site; other site 1116391020075 16S rRNA interaction site [nucleotide binding]; other site 1116391020076 streptomycin interaction site [chemical binding]; other site 1116391020077 23S rRNA interaction site [nucleotide binding]; other site 1116391020078 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1116391020079 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1116391020080 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1116391020081 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1116391020082 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1116391020083 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1116391020084 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1116391020085 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1116391020086 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1116391020087 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1116391020088 G-loop; other site 1116391020089 DNA binding site [nucleotide binding] 1116391020090 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 1116391020091 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1116391020092 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1116391020093 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1116391020094 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1116391020095 RPB10 interaction site [polypeptide binding]; other site 1116391020096 RPB1 interaction site [polypeptide binding]; other site 1116391020097 RPB11 interaction site [polypeptide binding]; other site 1116391020098 RPB3 interaction site [polypeptide binding]; other site 1116391020099 RPB12 interaction site [polypeptide binding]; other site 1116391020100 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1116391020101 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391020102 S-adenosylmethionine binding site [chemical binding]; other site 1116391020103 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1116391020104 core dimer interface [polypeptide binding]; other site 1116391020105 peripheral dimer interface [polypeptide binding]; other site 1116391020106 L10 interface [polypeptide binding]; other site 1116391020107 L11 interface [polypeptide binding]; other site 1116391020108 putative EF-Tu interaction site [polypeptide binding]; other site 1116391020109 putative EF-G interaction site [polypeptide binding]; other site 1116391020110 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1116391020111 23S rRNA interface [nucleotide binding]; other site 1116391020112 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1116391020113 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1116391020114 mRNA/rRNA interface [nucleotide binding]; other site 1116391020115 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1116391020116 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1116391020117 23S rRNA interface [nucleotide binding]; other site 1116391020118 L7/L12 interface [polypeptide binding]; other site 1116391020119 putative thiostrepton binding site; other site 1116391020120 L25 interface [polypeptide binding]; other site 1116391020121 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1116391020122 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1116391020123 putative homodimer interface [polypeptide binding]; other site 1116391020124 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1116391020125 heterodimer interface [polypeptide binding]; other site 1116391020126 homodimer interface [polypeptide binding]; other site 1116391020127 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1116391020128 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1116391020129 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1116391020130 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1116391020131 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1116391020132 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1116391020133 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1116391020134 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1116391020135 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1116391020136 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 1116391020137 active site 1116391020138 dimerization interface [polypeptide binding]; other site 1116391020139 metal binding site [ion binding]; metal-binding site 1116391020140 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1116391020141 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 1116391020142 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1116391020143 trimer interface [polypeptide binding]; other site 1116391020144 active site 1116391020145 substrate binding site [chemical binding]; other site 1116391020146 CoA binding site [chemical binding]; other site 1116391020147 Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565 1116391020148 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1116391020149 homotrimer interaction site [polypeptide binding]; other site 1116391020150 zinc binding site [ion binding]; other site 1116391020151 CDP-binding sites; other site 1116391020152 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1116391020153 substrate binding site; other site 1116391020154 dimer interface; other site 1116391020155 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1116391020156 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1116391020157 putative active site [active] 1116391020158 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1116391020159 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1116391020160 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1116391020161 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1116391020162 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1116391020163 DNA repair protein RadA; Provisional; Region: PRK11823 1116391020164 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1116391020165 Walker A motif/ATP binding site; other site 1116391020166 ATP binding site [chemical binding]; other site 1116391020167 Walker B motif; other site 1116391020168 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1116391020169 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1116391020170 Clp amino terminal domain; Region: Clp_N; pfam02861 1116391020171 Clp amino terminal domain; Region: Clp_N; pfam02861 1116391020172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391020173 Walker A motif; other site 1116391020174 ATP binding site [chemical binding]; other site 1116391020175 Walker B motif; other site 1116391020176 arginine finger; other site 1116391020177 UvrB/uvrC motif; Region: UVR; pfam02151 1116391020178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391020179 Walker A motif; other site 1116391020180 ATP binding site [chemical binding]; other site 1116391020181 Walker B motif; other site 1116391020182 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1116391020183 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1116391020184 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1116391020185 ADP binding site [chemical binding]; other site 1116391020186 phosphagen binding site; other site 1116391020187 substrate specificity loop; other site 1116391020188 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1116391020189 UvrB/uvrC motif; Region: UVR; pfam02151 1116391020190 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1116391020191 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1116391020192 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1116391020193 dimer interface [polypeptide binding]; other site 1116391020194 putative anticodon binding site; other site 1116391020195 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1116391020196 motif 1; other site 1116391020197 active site 1116391020198 motif 2; other site 1116391020199 motif 3; other site 1116391020200 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1116391020201 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1116391020202 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1116391020203 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1116391020204 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1116391020205 FMN binding site [chemical binding]; other site 1116391020206 active site 1116391020207 catalytic residues [active] 1116391020208 substrate binding site [chemical binding]; other site 1116391020209 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391020210 non-specific DNA binding site [nucleotide binding]; other site 1116391020211 salt bridge; other site 1116391020212 sequence-specific DNA binding site [nucleotide binding]; other site 1116391020213 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1116391020214 catalytic center binding site [active] 1116391020215 ATP binding site [chemical binding]; other site 1116391020216 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1116391020217 homooctamer interface [polypeptide binding]; other site 1116391020218 active site 1116391020219 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1116391020220 dihydropteroate synthase; Region: DHPS; TIGR01496 1116391020221 substrate binding pocket [chemical binding]; other site 1116391020222 dimer interface [polypeptide binding]; other site 1116391020223 inhibitor binding site; inhibition site 1116391020224 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1116391020225 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 1116391020226 homodimer interface [polypeptide binding]; other site 1116391020227 substrate-cofactor binding pocket; other site 1116391020228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391020229 catalytic residue [active] 1116391020230 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1116391020231 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1116391020232 glutamine binding [chemical binding]; other site 1116391020233 catalytic triad [active] 1116391020234 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1116391020235 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1116391020236 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1116391020237 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1116391020238 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1116391020239 dimer interface [polypeptide binding]; other site 1116391020240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1116391020241 catalytic residue [active] 1116391020242 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1116391020243 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1116391020244 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1116391020245 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1116391020246 dimerization interface [polypeptide binding]; other site 1116391020247 domain crossover interface; other site 1116391020248 redox-dependent activation switch; other site 1116391020249 pantothenate kinase; Reviewed; Region: PRK13318 1116391020250 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1116391020251 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1116391020252 dimerization interface [polypeptide binding]; other site 1116391020253 active site 1116391020254 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1116391020255 L-aspartate oxidase; Provisional; Region: PRK06175 1116391020256 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1116391020257 Quinolinate synthetase A protein; Region: NadA; pfam02445 1116391020258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1116391020259 active site 1116391020260 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1116391020261 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1116391020262 Ligand Binding Site [chemical binding]; other site 1116391020263 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1116391020264 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1116391020265 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1116391020266 active site 1116391020267 ATP binding site [chemical binding]; other site 1116391020268 substrate binding site [chemical binding]; other site 1116391020269 activation loop (A-loop); other site 1116391020270 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1116391020271 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1116391020272 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1116391020273 RNA binding site [nucleotide binding]; other site 1116391020274 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1116391020275 Septum formation initiator; Region: DivIC; pfam04977 1116391020276 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 1116391020277 YabP family; Region: YabP; cl06766 1116391020278 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1116391020279 RNA binding surface [nucleotide binding]; other site 1116391020280 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1116391020281 IHF dimer interface [polypeptide binding]; other site 1116391020282 IHF - DNA interface [nucleotide binding]; other site 1116391020283 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1116391020284 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1116391020285 putative SAM binding site [chemical binding]; other site 1116391020286 putative homodimer interface [polypeptide binding]; other site 1116391020287 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1116391020288 homodimer interface [polypeptide binding]; other site 1116391020289 metal binding site [ion binding]; metal-binding site 1116391020290 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1116391020291 homodimer interface [polypeptide binding]; other site 1116391020292 active site 1116391020293 putative chemical substrate binding site [chemical binding]; other site 1116391020294 metal binding site [ion binding]; metal-binding site 1116391020295 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1116391020296 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1116391020297 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1116391020298 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1116391020299 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1116391020300 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1116391020301 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1116391020302 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1116391020303 ATP binding site [chemical binding]; other site 1116391020304 putative Mg++ binding site [ion binding]; other site 1116391020305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1116391020306 nucleotide binding region [chemical binding]; other site 1116391020307 ATP-binding site [chemical binding]; other site 1116391020308 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1116391020309 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1116391020310 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1116391020311 putative active site [active] 1116391020312 catalytic residue [active] 1116391020313 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1116391020314 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1116391020315 5S rRNA interface [nucleotide binding]; other site 1116391020316 CTC domain interface [polypeptide binding]; other site 1116391020317 L16 interface [polypeptide binding]; other site 1116391020318 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1116391020319 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1116391020320 Substrate binding site; other site 1116391020321 Mg++ binding site; other site 1116391020322 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1116391020323 active site 1116391020324 substrate binding site [chemical binding]; other site 1116391020325 CoA binding site [chemical binding]; other site 1116391020326 SpoVG; Region: SpoVG; cl00915 1116391020327 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1116391020328 homotrimer interaction site [polypeptide binding]; other site 1116391020329 putative active site [active] 1116391020330 pur operon repressor; Provisional; Region: PRK09213 1116391020331 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1116391020332 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1116391020333 active site 1116391020334 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1116391020335 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1116391020336 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1116391020337 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1116391020338 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1116391020339 YabG peptidase U57; Region: Peptidase_U57; cl05250 1116391020340 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1116391020341 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391020342 S-adenosylmethionine binding site [chemical binding]; other site 1116391020343 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1116391020344 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1116391020345 putative active site [active] 1116391020346 putative metal binding site [ion binding]; other site 1116391020347 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1116391020348 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1116391020349 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1116391020350 G5 domain; Region: G5; pfam07501 1116391020351 3D domain; Region: 3D; cl01439 1116391020352 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1116391020353 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1116391020354 active site 1116391020355 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1116391020356 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1116391020357 Zn2+ binding site [ion binding]; other site 1116391020358 Mg2+ binding site [ion binding]; other site 1116391020359 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1116391020360 Predicted methyltransferases [General function prediction only]; Region: COG0313 1116391020361 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1116391020362 putative SAM binding site [chemical binding]; other site 1116391020363 putative homodimer interface [polypeptide binding]; other site 1116391020364 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1116391020365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391020366 S-adenosylmethionine binding site [chemical binding]; other site 1116391020367 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1116391020368 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1116391020369 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1116391020370 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1116391020371 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1116391020372 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1116391020373 thymidylate kinase; Validated; Region: tmk; PRK00698 1116391020374 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1116391020375 TMP-binding site; other site 1116391020376 ATP-binding site [chemical binding]; other site 1116391020377 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 1116391020378 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1116391020379 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1116391020380 catalytic residue [active] 1116391020381 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1116391020382 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 1116391020383 recombination protein RecR; Reviewed; Region: recR; PRK00076 1116391020384 RecR protein; Region: RecR; pfam02132 1116391020385 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1116391020386 putative active site [active] 1116391020387 putative metal-binding site [ion binding]; other site 1116391020388 tetramer interface [polypeptide binding]; other site 1116391020389 hypothetical protein; Validated; Region: PRK00153 1116391020390 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1116391020391 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391020392 Walker A motif; other site 1116391020393 ATP binding site [chemical binding]; other site 1116391020394 Walker B motif; other site 1116391020395 arginine finger; other site 1116391020396 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1116391020397 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1116391020398 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1116391020399 putative active site [active] 1116391020400 heme pocket [chemical binding]; other site 1116391020401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391020402 dimer interface [polypeptide binding]; other site 1116391020403 phosphorylation site [posttranslational modification] 1116391020404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391020405 ATP binding site [chemical binding]; other site 1116391020406 Mg2+ binding site [ion binding]; other site 1116391020407 G-X-G motif; other site 1116391020408 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1116391020409 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391020410 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1116391020411 FeS/SAM binding site; other site 1116391020412 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1116391020413 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1116391020414 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1116391020415 RNA binding site [nucleotide binding]; other site 1116391020416 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1116391020417 multimer interface [polypeptide binding]; other site 1116391020418 Walker A motif; other site 1116391020419 ATP binding site [chemical binding]; other site 1116391020420 Walker B motif; other site 1116391020421 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1116391020422 hinge; other site 1116391020423 active site 1116391020424 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1116391020425 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1116391020426 intersubunit interface [polypeptide binding]; other site 1116391020427 active site 1116391020428 zinc binding site [ion binding]; other site 1116391020429 Na+ binding site [ion binding]; other site 1116391020430 Response regulator receiver domain; Region: Response_reg; pfam00072 1116391020431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391020432 active site 1116391020433 phosphorylation site [posttranslational modification] 1116391020434 intermolecular recognition site; other site 1116391020435 dimerization interface [polypeptide binding]; other site 1116391020436 CTP synthetase; Validated; Region: pyrG; PRK05380 1116391020437 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1116391020438 Catalytic site [active] 1116391020439 active site 1116391020440 UTP binding site [chemical binding]; other site 1116391020441 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1116391020442 active site 1116391020443 putative oxyanion hole; other site 1116391020444 catalytic triad [active] 1116391020445 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 1116391020446 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1116391020447 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1116391020448 active site 1116391020449 catalytic residues [active] 1116391020450 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1116391020451 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391020452 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1116391020453 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391020454 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1116391020455 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1116391020456 putative active site [active] 1116391020457 putative metal binding site [ion binding]; other site 1116391020458 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 1116391020459 agmatinase; Region: agmatinase; TIGR01230 1116391020460 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 1116391020461 putative active site [active] 1116391020462 Mn binding site [ion binding]; other site 1116391020463 spermidine synthase; Provisional; Region: PRK00811 1116391020464 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391020465 Transglycosylase; Region: Transgly; pfam00912 1116391020466 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1116391020467 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1116391020468 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 1116391020469 PBP superfamily domain; Region: PBP_like_2; cl17296 1116391020470 YwhD family; Region: YwhD; pfam08741 1116391020471 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 1116391020472 Zn binding site [ion binding]; other site 1116391020473 NlpC/P60 family; Region: NLPC_P60; pfam00877 1116391020474 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 1116391020475 DNA photolyase; Region: DNA_photolyase; pfam00875 1116391020476 PspC domain; Region: PspC; pfam04024 1116391020477 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 1116391020478 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1116391020479 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1116391020480 active site residue [active] 1116391020481 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1116391020482 active site residue [active] 1116391020483 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1116391020484 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1116391020485 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 1116391020486 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391020487 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391020488 dimer interface [polypeptide binding]; other site 1116391020489 putative CheW interface [polypeptide binding]; other site 1116391020490 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1116391020491 aromatic arch; other site 1116391020492 DCoH dimer interaction site [polypeptide binding]; other site 1116391020493 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1116391020494 DCoH tetramer interaction site [polypeptide binding]; other site 1116391020495 substrate binding site [chemical binding]; other site 1116391020496 SNF2 Helicase protein; Region: DUF3670; pfam12419 1116391020497 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1116391020498 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1116391020499 ATP binding site [chemical binding]; other site 1116391020500 putative Mg++ binding site [ion binding]; other site 1116391020501 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1116391020502 nucleotide binding region [chemical binding]; other site 1116391020503 ATP-binding site [chemical binding]; other site 1116391020504 CHASE3 domain; Region: CHASE3; pfam05227 1116391020505 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1116391020506 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391020507 dimer interface [polypeptide binding]; other site 1116391020508 phosphorylation site [posttranslational modification] 1116391020509 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391020510 ATP binding site [chemical binding]; other site 1116391020511 Mg2+ binding site [ion binding]; other site 1116391020512 G-X-G motif; other site 1116391020513 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1116391020514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391020515 active site 1116391020516 phosphorylation site [posttranslational modification] 1116391020517 intermolecular recognition site; other site 1116391020518 dimerization interface [polypeptide binding]; other site 1116391020519 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1116391020520 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1116391020521 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1116391020522 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1116391020523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1116391020524 Uncharacterized conserved protein [Function unknown]; Region: COG2308 1116391020525 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1116391020526 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1116391020527 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1116391020528 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1116391020529 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1116391020530 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1116391020531 NAD binding site [chemical binding]; other site 1116391020532 homodimer interface [polypeptide binding]; other site 1116391020533 active site 1116391020534 substrate binding site [chemical binding]; other site 1116391020535 galactokinase; Provisional; Region: PRK05322 1116391020536 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1116391020537 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1116391020538 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1116391020539 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391020540 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391020541 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391020542 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391020543 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1116391020544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391020545 dimer interface [polypeptide binding]; other site 1116391020546 phosphorylation site [posttranslational modification] 1116391020547 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391020548 ATP binding site [chemical binding]; other site 1116391020549 Mg2+ binding site [ion binding]; other site 1116391020550 G-X-G motif; other site 1116391020551 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391020552 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391020553 active site 1116391020554 phosphorylation site [posttranslational modification] 1116391020555 intermolecular recognition site; other site 1116391020556 dimerization interface [polypeptide binding]; other site 1116391020557 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391020558 DNA binding site [nucleotide binding] 1116391020559 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1116391020560 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1116391020561 RNA binding surface [nucleotide binding]; other site 1116391020562 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1116391020563 probable active site [active] 1116391020564 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1116391020565 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1116391020566 active site 1116391020567 Transglycosylase; Region: Transgly; pfam00912 1116391020568 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1116391020569 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1116391020570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391020571 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391020572 putative substrate translocation pore; other site 1116391020573 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1116391020574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391020575 putative substrate translocation pore; other site 1116391020576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391020577 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1116391020578 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391020579 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1116391020580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391020581 motif II; other site 1116391020582 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1116391020583 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 1116391020584 putative FMN binding site [chemical binding]; other site 1116391020585 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1116391020586 putative active site [active] 1116391020587 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 1116391020588 HTH-like domain; Region: HTH_21; pfam13276 1116391020589 Integrase core domain; Region: rve; pfam00665 1116391020590 Integrase core domain; Region: rve_2; pfam13333 1116391020591 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391020592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1116391020593 Transposase; Region: HTH_Tnp_1; cl17663 1116391020594 Helix-turn-helix domain; Region: HTH_28; pfam13518 1116391020595 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1116391020596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391020597 putative substrate translocation pore; other site 1116391020598 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1116391020599 HlyD family secretion protein; Region: HlyD_3; pfam13437 1116391020600 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1116391020601 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1116391020602 E3 interaction surface; other site 1116391020603 lipoyl attachment site [posttranslational modification]; other site 1116391020604 HlyD family secretion protein; Region: HlyD_3; pfam13437 1116391020605 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391020606 MarR family; Region: MarR; pfam01047 1116391020607 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391020608 MarR family; Region: MarR_2; pfam12802 1116391020609 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1116391020610 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391020611 S-adenosylmethionine binding site [chemical binding]; other site 1116391020612 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1116391020613 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1116391020614 xanthine permease; Region: pbuX; TIGR03173 1116391020615 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391020616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391020617 dimer interface [polypeptide binding]; other site 1116391020618 conserved gate region; other site 1116391020619 putative PBP binding loops; other site 1116391020620 ABC-ATPase subunit interface; other site 1116391020621 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391020622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391020623 putative PBP binding loops; other site 1116391020624 dimer interface [polypeptide binding]; other site 1116391020625 ABC-ATPase subunit interface; other site 1116391020626 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391020627 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391020628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391020629 active site 1116391020630 phosphorylation site [posttranslational modification] 1116391020631 intermolecular recognition site; other site 1116391020632 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391020633 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391020634 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391020635 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391020636 dimerization interface [polypeptide binding]; other site 1116391020637 Histidine kinase; Region: His_kinase; pfam06580 1116391020638 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391020639 ATP binding site [chemical binding]; other site 1116391020640 Mg2+ binding site [ion binding]; other site 1116391020641 G-X-G motif; other site 1116391020642 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1116391020643 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1116391020644 dimerization interface [polypeptide binding]; other site 1116391020645 DPS ferroxidase diiron center [ion binding]; other site 1116391020646 ion pore; other site 1116391020647 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1116391020648 SpoOM protein; Region: Spo0M; pfam07070 1116391020649 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1116391020650 active site 1116391020651 substrate binding site [chemical binding]; other site 1116391020652 ATP binding site [chemical binding]; other site 1116391020653 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1116391020654 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 1116391020655 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1116391020656 putative active site [active] 1116391020657 catalytic site [active] 1116391020658 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1116391020659 putative active site [active] 1116391020660 catalytic site [active] 1116391020661 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1116391020662 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1116391020663 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1116391020664 active site 1116391020665 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1116391020666 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391020667 putative DNA binding site [nucleotide binding]; other site 1116391020668 putative Zn2+ binding site [ion binding]; other site 1116391020669 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1116391020670 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1116391020671 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1116391020672 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1116391020673 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391020674 non-specific DNA binding site [nucleotide binding]; other site 1116391020675 salt bridge; other site 1116391020676 sequence-specific DNA binding site [nucleotide binding]; other site 1116391020677 Cupin domain; Region: Cupin_2; pfam07883 1116391020678 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1116391020679 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391020680 S-adenosylmethionine binding site [chemical binding]; other site 1116391020681 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1116391020682 flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046 1116391020683 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1116391020684 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1116391020685 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1116391020686 apolar tunnel; other site 1116391020687 heme binding site [chemical binding]; other site 1116391020688 dimerization interface [polypeptide binding]; other site 1116391020689 Uncharacterized conserved protein [Function unknown]; Region: COG1801 1116391020690 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1116391020691 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1116391020692 dimer interface [polypeptide binding]; other site 1116391020693 motif 1; other site 1116391020694 active site 1116391020695 motif 2; other site 1116391020696 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1116391020697 putative deacylase active site [active] 1116391020698 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1116391020699 active site 1116391020700 motif 3; other site 1116391020701 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1116391020702 anticodon binding site; other site 1116391020703 EcsC protein family; Region: EcsC; pfam12787 1116391020704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1116391020705 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1116391020706 major capsid L1 protein; Provisional; Region: PHA02778 1116391020707 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1116391020708 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1116391020709 active site 1116391020710 HIGH motif; other site 1116391020711 nucleotide binding site [chemical binding]; other site 1116391020712 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1116391020713 KMSKS motif; other site 1116391020714 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1116391020715 GTPase RsgA; Reviewed; Region: PRK01889 1116391020716 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1116391020717 RNA binding site [nucleotide binding]; other site 1116391020718 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1116391020719 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1116391020720 GTP/Mg2+ binding site [chemical binding]; other site 1116391020721 G4 box; other site 1116391020722 G5 box; other site 1116391020723 G1 box; other site 1116391020724 Switch I region; other site 1116391020725 G2 box; other site 1116391020726 G3 box; other site 1116391020727 Switch II region; other site 1116391020728 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1116391020729 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1116391020730 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391020731 putative Zn2+ binding site [ion binding]; other site 1116391020732 putative DNA binding site [nucleotide binding]; other site 1116391020733 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1116391020734 Cache domain; Region: Cache_1; pfam02743 1116391020735 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391020736 dimerization interface [polypeptide binding]; other site 1116391020737 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391020738 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391020739 dimer interface [polypeptide binding]; other site 1116391020740 putative CheW interface [polypeptide binding]; other site 1116391020741 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 1116391020742 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 1116391020743 Glutamate binding site [chemical binding]; other site 1116391020744 homodimer interface [polypeptide binding]; other site 1116391020745 NAD binding site [chemical binding]; other site 1116391020746 catalytic residues [active] 1116391020747 Proline dehydrogenase; Region: Pro_dh; cl03282 1116391020748 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1116391020749 PAS domain; Region: PAS_9; pfam13426 1116391020750 putative active site [active] 1116391020751 heme pocket [chemical binding]; other site 1116391020752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1116391020753 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 1116391020754 Walker A motif; other site 1116391020755 ATP binding site [chemical binding]; other site 1116391020756 Walker B motif; other site 1116391020757 arginine finger; other site 1116391020758 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1116391020759 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1116391020760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391020761 active site 1116391020762 phosphorylation site [posttranslational modification] 1116391020763 intermolecular recognition site; other site 1116391020764 dimerization interface [polypeptide binding]; other site 1116391020765 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1116391020766 DNA binding residues [nucleotide binding] 1116391020767 dimerization interface [polypeptide binding]; other site 1116391020768 GAF domain; Region: GAF_2; pfam13185 1116391020769 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1116391020770 Histidine kinase; Region: HisKA_3; pfam07730 1116391020771 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391020772 ATP binding site [chemical binding]; other site 1116391020773 Mg2+ binding site [ion binding]; other site 1116391020774 G-X-G motif; other site 1116391020775 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1116391020776 pentamer interface [polypeptide binding]; other site 1116391020777 dodecaamer interface [polypeptide binding]; other site 1116391020778 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1116391020779 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1116391020780 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1116391020781 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1116391020782 Coenzyme A binding pocket [chemical binding]; other site 1116391020783 Heat induced stress protein YflT; Region: YflT; pfam11181 1116391020784 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1116391020785 Catalytic site [active] 1116391020786 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1116391020787 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 1116391020788 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1116391020789 Fe-S cluster binding site [ion binding]; other site 1116391020790 active site 1116391020791 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1116391020792 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1116391020793 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1116391020794 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1116391020795 active site 1116391020796 Zn binding site [ion binding]; other site 1116391020797 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1116391020798 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1116391020799 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1116391020800 DEAD_2; Region: DEAD_2; pfam06733 1116391020801 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1116391020802 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1116391020803 MarR family; Region: MarR; pfam01047 1116391020804 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1116391020805 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391020806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1116391020807 Walker A/P-loop; other site 1116391020808 ATP binding site [chemical binding]; other site 1116391020809 Q-loop/lid; other site 1116391020810 ABC transporter signature motif; other site 1116391020811 Walker B; other site 1116391020812 D-loop; other site 1116391020813 H-loop/switch region; other site 1116391020814 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1116391020815 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1116391020816 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1116391020817 Walker A/P-loop; other site 1116391020818 ATP binding site [chemical binding]; other site 1116391020819 Q-loop/lid; other site 1116391020820 ABC transporter signature motif; other site 1116391020821 Walker B; other site 1116391020822 D-loop; other site 1116391020823 H-loop/switch region; other site 1116391020824 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 1116391020825 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1116391020826 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1116391020827 dimerization interface [polypeptide binding]; other site 1116391020828 DPS ferroxidase diiron center [ion binding]; other site 1116391020829 ion pore; other site 1116391020830 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1116391020831 metal binding site 2 [ion binding]; metal-binding site 1116391020832 putative DNA binding helix; other site 1116391020833 metal binding site 1 [ion binding]; metal-binding site 1116391020834 dimer interface [polypeptide binding]; other site 1116391020835 structural Zn2+ binding site [ion binding]; other site 1116391020836 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391020837 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391020838 DNA binding site [nucleotide binding] 1116391020839 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1116391020840 metal binding site 2 [ion binding]; metal-binding site 1116391020841 putative DNA binding helix; other site 1116391020842 metal binding site 1 [ion binding]; metal-binding site 1116391020843 dimer interface [polypeptide binding]; other site 1116391020844 structural Zn2+ binding site [ion binding]; other site 1116391020845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1116391020846 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1116391020847 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 1116391020848 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1116391020849 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1116391020850 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391020851 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1116391020852 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1116391020853 active site 1116391020854 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1116391020855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391020856 dimer interface [polypeptide binding]; other site 1116391020857 conserved gate region; other site 1116391020858 putative PBP binding loops; other site 1116391020859 ABC-ATPase subunit interface; other site 1116391020860 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1116391020861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391020862 dimer interface [polypeptide binding]; other site 1116391020863 conserved gate region; other site 1116391020864 ABC-ATPase subunit interface; other site 1116391020865 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391020866 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391020867 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391020868 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391020869 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391020870 MAEBL; Provisional; Region: PTZ00121 1116391020871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1116391020872 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391020873 dimerization interface [polypeptide binding]; other site 1116391020874 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391020875 dimer interface [polypeptide binding]; other site 1116391020876 phosphorylation site [posttranslational modification] 1116391020877 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391020878 ATP binding site [chemical binding]; other site 1116391020879 Mg2+ binding site [ion binding]; other site 1116391020880 G-X-G motif; other site 1116391020881 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391020882 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391020883 active site 1116391020884 phosphorylation site [posttranslational modification] 1116391020885 intermolecular recognition site; other site 1116391020886 dimerization interface [polypeptide binding]; other site 1116391020887 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391020888 DNA binding site [nucleotide binding] 1116391020889 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 1116391020890 non-specific DNA binding site [nucleotide binding]; other site 1116391020891 salt bridge; other site 1116391020892 sequence-specific DNA binding site [nucleotide binding]; other site 1116391020893 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1116391020894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1116391020895 non-specific DNA binding site [nucleotide binding]; other site 1116391020896 salt bridge; other site 1116391020897 sequence-specific DNA binding site [nucleotide binding]; other site 1116391020898 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1116391020899 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1116391020900 Walker A/P-loop; other site 1116391020901 ATP binding site [chemical binding]; other site 1116391020902 Q-loop/lid; other site 1116391020903 ABC transporter signature motif; other site 1116391020904 Walker B; other site 1116391020905 D-loop; other site 1116391020906 H-loop/switch region; other site 1116391020907 PAS domain S-box; Region: sensory_box; TIGR00229 1116391020908 PAS domain; Region: PAS_8; pfam13188 1116391020909 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1116391020910 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1116391020911 metal binding site [ion binding]; metal-binding site 1116391020912 active site 1116391020913 I-site; other site 1116391020914 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1116391020915 Cache domain; Region: Cache_1; pfam02743 1116391020916 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391020917 dimerization interface [polypeptide binding]; other site 1116391020918 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391020919 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391020920 dimer interface [polypeptide binding]; other site 1116391020921 putative CheW interface [polypeptide binding]; other site 1116391020922 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391020923 Interdomain contacts; other site 1116391020924 Cytokine receptor motif; other site 1116391020925 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391020926 Interdomain contacts; other site 1116391020927 Cytokine receptor motif; other site 1116391020928 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1116391020929 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391020930 Interdomain contacts; other site 1116391020931 Cytokine receptor motif; other site 1116391020932 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 1116391020933 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1116391020934 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1116391020935 DNA-binding site [nucleotide binding]; DNA binding site 1116391020936 RNA-binding motif; other site 1116391020937 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1116391020938 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1116391020939 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391020940 dimerization interface [polypeptide binding]; other site 1116391020941 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391020942 dimer interface [polypeptide binding]; other site 1116391020943 putative CheW interface [polypeptide binding]; other site 1116391020944 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1116391020945 glycerol kinase; Provisional; Region: glpK; PRK00047 1116391020946 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1116391020947 N- and C-terminal domain interface [polypeptide binding]; other site 1116391020948 active site 1116391020949 MgATP binding site [chemical binding]; other site 1116391020950 catalytic site [active] 1116391020951 metal binding site [ion binding]; metal-binding site 1116391020952 glycerol binding site [chemical binding]; other site 1116391020953 homotetramer interface [polypeptide binding]; other site 1116391020954 homodimer interface [polypeptide binding]; other site 1116391020955 FBP binding site [chemical binding]; other site 1116391020956 protein IIAGlc interface [polypeptide binding]; other site 1116391020957 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1116391020958 amphipathic channel; other site 1116391020959 Asn-Pro-Ala signature motifs; other site 1116391020960 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1116391020961 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1116391020962 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1116391020963 putative ligand binding residues [chemical binding]; other site 1116391020964 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1116391020965 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1116391020966 Walker A/P-loop; other site 1116391020967 ATP binding site [chemical binding]; other site 1116391020968 Q-loop/lid; other site 1116391020969 ABC transporter signature motif; other site 1116391020970 Walker B; other site 1116391020971 D-loop; other site 1116391020972 H-loop/switch region; other site 1116391020973 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391020974 ABC-ATPase subunit interface; other site 1116391020975 dimer interface [polypeptide binding]; other site 1116391020976 putative PBP binding regions; other site 1116391020977 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1116391020978 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1116391020979 ABC-ATPase subunit interface; other site 1116391020980 dimer interface [polypeptide binding]; other site 1116391020981 putative PBP binding regions; other site 1116391020982 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1116391020983 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1116391020984 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1116391020985 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1116391020986 active site 1116391020987 HIGH motif; other site 1116391020988 nucleotide binding site [chemical binding]; other site 1116391020989 active site 1116391020990 KMSKS motif; other site 1116391020991 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1116391020992 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1116391020993 YceI-like domain; Region: YceI; pfam04264 1116391020994 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 1116391020995 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1116391020996 short chain dehydrogenase; Provisional; Region: PRK06701 1116391020997 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1116391020998 NAD binding site [chemical binding]; other site 1116391020999 metal binding site [ion binding]; metal-binding site 1116391021000 active site 1116391021001 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1116391021002 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1116391021003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391021004 dimerization interface [polypeptide binding]; other site 1116391021005 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1116391021006 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1116391021007 dimer interface [polypeptide binding]; other site 1116391021008 putative CheW interface [polypeptide binding]; other site 1116391021009 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1116391021010 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1116391021011 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1116391021012 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1116391021013 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1116391021014 Walker A/P-loop; other site 1116391021015 ATP binding site [chemical binding]; other site 1116391021016 Q-loop/lid; other site 1116391021017 ABC transporter signature motif; other site 1116391021018 Walker B; other site 1116391021019 D-loop; other site 1116391021020 H-loop/switch region; other site 1116391021021 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1116391021022 active site 1116391021023 catalytic triad [active] 1116391021024 oxyanion hole [active] 1116391021025 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1116391021026 EamA-like transporter family; Region: EamA; pfam00892 1116391021027 EamA-like transporter family; Region: EamA; pfam00892 1116391021028 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1116391021029 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1116391021030 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1116391021031 hypothetical protein; Provisional; Region: PRK08236 1116391021032 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 1116391021033 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1116391021034 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1116391021035 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1116391021036 S-layer homology domain; Region: SLH; pfam00395 1116391021037 S-layer homology domain; Region: SLH; pfam00395 1116391021038 DNA Topoisomerase I (eukaryota); Region: TOPEUc; smart00435 1116391021039 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1116391021040 dimerization interface [polypeptide binding]; other site 1116391021041 putative DNA binding site [nucleotide binding]; other site 1116391021042 putative Zn2+ binding site [ion binding]; other site 1116391021043 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 1116391021044 putative hydrophobic ligand binding site [chemical binding]; other site 1116391021045 Predicted transcriptional regulator [Transcription]; Region: COG1959 1116391021046 Transcriptional regulator; Region: Rrf2; pfam02082 1116391021047 MMPL family; Region: MMPL; pfam03176 1116391021048 MMPL family; Region: MMPL; pfam03176 1116391021049 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1116391021050 Family description; Region: VCBS; pfam13517 1116391021051 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 1116391021052 putative inhibitory loop; other site 1116391021053 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391021054 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391021055 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391021056 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1116391021057 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1116391021058 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1116391021059 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1116391021060 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1116391021061 tetramer interface [polypeptide binding]; other site 1116391021062 active site 1116391021063 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1116391021064 active site 1116391021065 dimer interface [polypeptide binding]; other site 1116391021066 magnesium binding site [ion binding]; other site 1116391021067 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391021068 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391021069 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1116391021070 classical (c) SDRs; Region: SDR_c; cd05233 1116391021071 NAD(P) binding site [chemical binding]; other site 1116391021072 active site 1116391021073 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1116391021074 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 1116391021075 tetramer interface [polypeptide binding]; other site 1116391021076 heme binding pocket [chemical binding]; other site 1116391021077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1116391021078 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391021079 S-adenosylmethionine binding site [chemical binding]; other site 1116391021080 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391021081 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1116391021082 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1116391021083 Walker A/P-loop; other site 1116391021084 ATP binding site [chemical binding]; other site 1116391021085 Q-loop/lid; other site 1116391021086 ABC transporter signature motif; other site 1116391021087 Walker B; other site 1116391021088 D-loop; other site 1116391021089 H-loop/switch region; other site 1116391021090 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1116391021091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1116391021092 dimer interface [polypeptide binding]; other site 1116391021093 conserved gate region; other site 1116391021094 putative PBP binding loops; other site 1116391021095 ABC-ATPase subunit interface; other site 1116391021096 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1116391021097 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1116391021098 substrate binding pocket [chemical binding]; other site 1116391021099 membrane-bound complex binding site; other site 1116391021100 hinge residues; other site 1116391021101 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1116391021102 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1116391021103 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1116391021104 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1116391021105 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1116391021106 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1116391021107 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1116391021108 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 1116391021109 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1116391021110 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1116391021111 TPR repeat; Region: TPR_11; pfam13414 1116391021112 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1116391021113 active site 1116391021114 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1116391021115 DNA binding site [nucleotide binding] 1116391021116 active site 1116391021117 CsbD-like; Region: CsbD; pfam05532 1116391021118 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1116391021119 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1116391021120 S-adenosylmethionine binding site [chemical binding]; other site 1116391021121 Predicted transcriptional regulators [Transcription]; Region: COG1733 1116391021122 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1116391021123 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1116391021124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391021125 putative substrate translocation pore; other site 1116391021126 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1116391021127 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1116391021128 active site 1116391021129 catalytic tetrad [active] 1116391021130 xanthine permease; Region: pbuX; TIGR03173 1116391021131 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1116391021132 active site 1116391021133 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1116391021134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391021135 putative substrate translocation pore; other site 1116391021136 POT family; Region: PTR2; cl17359 1116391021137 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1116391021138 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1116391021139 FeS/SAM binding site; other site 1116391021140 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1116391021141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1116391021142 putative substrate translocation pore; other site 1116391021143 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1116391021144 GIY-YIG motif/motif A; other site 1116391021145 active site 1116391021146 catalytic site [active] 1116391021147 putative DNA binding site [nucleotide binding]; other site 1116391021148 metal binding site [ion binding]; metal-binding site 1116391021149 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1116391021150 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1116391021151 PhnA protein; Region: PhnA; pfam03831 1116391021152 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1116391021153 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1116391021154 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1116391021155 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1116391021156 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1116391021157 active site 1116391021158 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391021159 Interdomain contacts; other site 1116391021160 Cytokine receptor motif; other site 1116391021161 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1116391021162 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391021163 Interdomain contacts; other site 1116391021164 Cytokine receptor motif; other site 1116391021165 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 1116391021166 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1116391021167 Interdomain contacts; other site 1116391021168 Cytokine receptor motif; other site 1116391021169 putative pectinesterase; Region: PLN02432; cl01911 1116391021170 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 1116391021171 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1116391021172 Amb_all domain; Region: Amb_all; smart00656 1116391021173 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1116391021174 Predicted transcriptional regulator [Transcription]; Region: COG2378 1116391021175 HTH domain; Region: HTH_11; pfam08279 1116391021176 WYL domain; Region: WYL; pfam13280 1116391021177 hypothetical protein; Provisional; Region: PRK02268 1116391021178 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1116391021179 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1116391021180 ATP binding site [chemical binding]; other site 1116391021181 Mg++ binding site [ion binding]; other site 1116391021182 motif III; other site 1116391021183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1116391021184 nucleotide binding region [chemical binding]; other site 1116391021185 ATP-binding site [chemical binding]; other site 1116391021186 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1116391021187 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1116391021188 dimerization interface [polypeptide binding]; other site 1116391021189 DPS ferroxidase diiron center [ion binding]; other site 1116391021190 ion pore; other site 1116391021191 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1116391021192 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1116391021193 TAP-like protein; Region: Abhydrolase_4; pfam08386 1116391021194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391021195 ATP binding site [chemical binding]; other site 1116391021196 Mg2+ binding site [ion binding]; other site 1116391021197 G-X-G motif; other site 1116391021198 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1116391021199 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391021200 active site 1116391021201 phosphorylation site [posttranslational modification] 1116391021202 intermolecular recognition site; other site 1116391021203 dimerization interface [polypeptide binding]; other site 1116391021204 LytTr DNA-binding domain; Region: LytTR; smart00850 1116391021205 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1116391021206 YyzF-like protein; Region: YyzF; pfam14116 1116391021207 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1116391021208 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1116391021209 protein binding site [polypeptide binding]; other site 1116391021210 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1116391021211 YycH protein; Region: YycI; cl02015 1116391021212 YycH protein; Region: YycH; pfam07435 1116391021213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1116391021214 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1116391021215 dimerization interface [polypeptide binding]; other site 1116391021216 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1116391021217 putative active site [active] 1116391021218 heme pocket [chemical binding]; other site 1116391021219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1116391021220 dimer interface [polypeptide binding]; other site 1116391021221 phosphorylation site [posttranslational modification] 1116391021222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1116391021223 ATP binding site [chemical binding]; other site 1116391021224 Mg2+ binding site [ion binding]; other site 1116391021225 G-X-G motif; other site 1116391021226 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1116391021227 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1116391021228 active site 1116391021229 phosphorylation site [posttranslational modification] 1116391021230 intermolecular recognition site; other site 1116391021231 dimerization interface [polypeptide binding]; other site 1116391021232 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1116391021233 DNA binding site [nucleotide binding] 1116391021234 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1116391021235 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1116391021236 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1116391021237 G5 domain; Region: G5; pfam07501 1116391021238 Peptidase family M23; Region: Peptidase_M23; pfam01551 1116391021239 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1116391021240 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1116391021241 GDP-binding site [chemical binding]; other site 1116391021242 ACT binding site; other site 1116391021243 IMP binding site; other site 1116391021244 replicative DNA helicase; Provisional; Region: PRK05748 1116391021245 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1116391021246 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1116391021247 Walker A motif; other site 1116391021248 ATP binding site [chemical binding]; other site 1116391021249 Walker B motif; other site 1116391021250 DNA binding loops [nucleotide binding] 1116391021251 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1116391021252 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1116391021253 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1116391021254 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1116391021255 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1116391021256 DHH family; Region: DHH; pfam01368 1116391021257 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 1116391021258 MazG-like family; Region: MazG-like; pfam12643 1116391021259 FOG: CBS domain [General function prediction only]; Region: COG0517 1116391021260 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1116391021261 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1116391021262 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1116391021263 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1116391021264 dimer interface [polypeptide binding]; other site 1116391021265 ssDNA binding site [nucleotide binding]; other site 1116391021266 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1116391021267 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1116391021268 YjzC-like protein; Region: YjzC; pfam14168 1116391021269 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1116391021270 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1116391021271 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1116391021272 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 1116391021273 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 1116391021274 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1116391021275 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1116391021276 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1116391021277 catalytic residue [active] 1116391021278 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1116391021279 ParB-like nuclease domain; Region: ParB; smart00470 1116391021280 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1116391021281 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1116391021282 P-loop; other site 1116391021283 Magnesium ion binding site [ion binding]; other site 1116391021284 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1116391021285 Magnesium ion binding site [ion binding]; other site 1116391021286 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1116391021287 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1116391021288 ParB-like nuclease domain; Region: ParB; smart00470 1116391021289 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1116391021290 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1116391021291 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1116391021292 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1116391021293 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1116391021294 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1116391021295 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1116391021296 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1116391021297 G1 box; other site 1116391021298 GTP/Mg2+ binding site [chemical binding]; other site 1116391021299 Switch I region; other site 1116391021300 G2 box; other site 1116391021301 Switch II region; other site 1116391021302 G3 box; other site 1116391021303 G4 box; other site 1116391021304 G5 box; other site 1116391021305 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1116391021306 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1116391021307 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1116391021308 G-X-X-G motif; other site 1116391021309 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1116391021310 RxxxH motif; other site 1116391021311 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1116391021312 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1116391021313 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399