-- dump date 20140619_225418 -- class Genbank::misc_feature -- table misc_feature_note -- id note 997761000001 DNA polymerase III subunit beta; Validated; Region: PRK05643 997761000002 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 997761000003 putative DNA binding surface [nucleotide binding]; other site 997761000004 dimer interface [polypeptide binding]; other site 997761000005 beta-clamp/clamp loader binding surface; other site 997761000006 beta-clamp/translesion DNA polymerase binding surface; other site 997761000007 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 997761000008 recombination protein F; Reviewed; Region: recF; PRK00064 997761000009 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 997761000010 Walker A/P-loop; other site 997761000011 ATP binding site [chemical binding]; other site 997761000012 Q-loop/lid; other site 997761000013 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761000014 ABC transporter signature motif; other site 997761000015 Walker B; other site 997761000016 D-loop; other site 997761000017 H-loop/switch region; other site 997761000018 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 997761000019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761000020 Mg2+ binding site [ion binding]; other site 997761000021 G-X-G motif; other site 997761000022 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 997761000023 anchoring element; other site 997761000024 dimer interface [polypeptide binding]; other site 997761000025 ATP binding site [chemical binding]; other site 997761000026 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 997761000027 active site 997761000028 putative metal-binding site [ion binding]; other site 997761000029 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 997761000030 DNA gyrase subunit A; Validated; Region: PRK05560 997761000031 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 997761000032 CAP-like domain; other site 997761000033 active site 997761000034 primary dimer interface [polypeptide binding]; other site 997761000035 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 997761000036 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 997761000037 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 997761000038 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 997761000039 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 997761000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 997761000041 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 997761000042 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 997761000043 Zn2+ binding site [ion binding]; other site 997761000044 Mg2+ binding site [ion binding]; other site 997761000045 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 997761000046 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 997761000047 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 997761000048 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 997761000049 active site 997761000050 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 997761000051 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 997761000052 active site 997761000053 multimer interface [polypeptide binding]; other site 997761000054 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 997761000055 predicted active site [active] 997761000056 catalytic triad [active] 997761000057 seryl-tRNA synthetase; Provisional; Region: PRK05431 997761000058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 997761000059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 997761000060 dimer interface [polypeptide binding]; other site 997761000061 active site 997761000062 motif 1; other site 997761000063 motif 2; other site 997761000064 motif 3; other site 997761000065 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 997761000066 Part of AAA domain; Region: AAA_19; pfam13245 997761000067 Family description; Region: UvrD_C_2; pfam13538 997761000068 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 997761000069 active site 997761000070 RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642 997761000071 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761000072 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761000073 DNA binding residues [nucleotide binding] 997761000074 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 997761000075 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 997761000076 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 997761000077 nucleoside/Zn binding site; other site 997761000078 dimer interface [polypeptide binding]; other site 997761000079 catalytic motif [active] 997761000080 PilZ domain; Region: PilZ; pfam07238 997761000081 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 997761000082 amidase catalytic site [active] 997761000083 Zn binding residues [ion binding]; other site 997761000084 substrate binding site [chemical binding]; other site 997761000085 GTP-binding protein YchF; Reviewed; Region: PRK09601 997761000086 YchF GTPase; Region: YchF; cd01900 997761000087 G1 box; other site 997761000088 GTP/Mg2+ binding site [chemical binding]; other site 997761000089 Switch I region; other site 997761000090 G2 box; other site 997761000091 Switch II region; other site 997761000092 G3 box; other site 997761000093 G4 box; other site 997761000094 G5 box; other site 997761000095 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 997761000096 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 997761000097 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 997761000098 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 997761000099 Predicted membrane protein [Function unknown]; Region: COG1971 997761000100 Domain of unknown function DUF; Region: DUF204; pfam02659 997761000101 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 997761000102 Low molecular weight phosphatase family; Region: LMWPc; cd00115 997761000103 active site 997761000104 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 997761000105 hypothetical protein; Provisional; Region: PRK13690 997761000106 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 997761000107 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 997761000108 dimer interface [polypeptide binding]; other site 997761000109 active site 997761000110 glycine-pyridoxal phosphate binding site [chemical binding]; other site 997761000111 folate binding site [chemical binding]; other site 997761000112 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 997761000113 active site 997761000114 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 997761000115 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 997761000116 active site 997761000117 homodimer interface [polypeptide binding]; other site 997761000118 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; cl09754 997761000119 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 997761000120 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 997761000121 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 997761000122 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 997761000123 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 997761000124 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 997761000125 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 997761000126 beta subunit interaction interface [polypeptide binding]; other site 997761000127 Walker A motif; other site 997761000128 ATP binding site [chemical binding]; other site 997761000129 Walker B motif; other site 997761000130 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 997761000131 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 997761000132 core domain interface [polypeptide binding]; other site 997761000133 delta subunit interface [polypeptide binding]; other site 997761000134 epsilon subunit interface [polypeptide binding]; other site 997761000135 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 997761000136 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 997761000137 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 997761000138 alpha subunit interaction interface [polypeptide binding]; other site 997761000139 Walker A motif; other site 997761000140 ATP binding site [chemical binding]; other site 997761000141 Walker B motif; other site 997761000142 inhibitor binding site; inhibition site 997761000143 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 997761000144 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 997761000145 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 997761000146 gamma subunit interface [polypeptide binding]; other site 997761000147 epsilon subunit interface [polypeptide binding]; other site 997761000148 LBP interface [polypeptide binding]; other site 997761000149 NADH dehydrogenase subunit A; Validated; Region: PRK07756 997761000150 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 997761000151 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 997761000152 NADH dehydrogenase subunit D; Provisional; Region: PRK12322 997761000153 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 997761000154 4Fe-4S binding domain; Region: Fer4; pfam00037 997761000155 4Fe-4S binding domain; Region: Fer4; pfam00037 997761000156 NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839 997761000157 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 997761000158 NADH dehydrogenase subunit J; Provisional; Region: PRK06439 997761000159 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 997761000160 proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974 997761000161 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 997761000162 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 997761000163 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 997761000164 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 997761000165 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 997761000166 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761000167 MarR family; Region: MarR; pfam01047 997761000168 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 997761000169 active site 997761000170 catalytic residues [active] 997761000171 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 997761000172 S-layer homology domain; Region: SLH; pfam00395 997761000173 S-layer homology domain; Region: SLH; pfam00395 997761000174 S-layer homology domain; Region: SLH; pfam00395 997761000175 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 997761000176 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 997761000177 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 997761000178 hinge; other site 997761000179 active site 997761000180 stage II sporulation protein D; Region: spore_II_D; TIGR02870 997761000181 Stage II sporulation protein; Region: SpoIID; pfam08486 997761000182 Stage III sporulation protein D; Region: SpoIIID; pfam12116 997761000183 rod shape-determining protein Mbl; Provisional; Region: PRK13928 997761000184 MreB and similar proteins; Region: MreB_like; cd10225 997761000185 nucleotide binding site [chemical binding]; other site 997761000186 Mg binding site [ion binding]; other site 997761000187 putative protofilament interaction site [polypeptide binding]; other site 997761000188 RodZ interaction site [polypeptide binding]; other site 997761000189 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 997761000190 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 997761000191 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 997761000192 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 997761000193 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 997761000194 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 997761000195 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 997761000196 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 997761000197 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 997761000198 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 997761000199 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 997761000200 active site 997761000201 substrate binding site [chemical binding]; other site 997761000202 metal binding site [ion binding]; metal-binding site 997761000203 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 997761000204 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 997761000205 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 997761000206 Mg++ binding site [ion binding]; other site 997761000207 putative catalytic motif [active] 997761000208 substrate binding site [chemical binding]; other site 997761000209 S-layer homology domain; Region: SLH; pfam00395 997761000210 S-layer homology domain; Region: SLH; pfam00395 997761000211 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 997761000212 S-adenosylmethionine synthetase; Validated; Region: PRK05250 997761000213 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 997761000214 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 997761000215 Sensor protein DegS; Region: DegS; pfam05384 997761000216 Histidine kinase; Region: HisKA_3; pfam07730 997761000217 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 997761000218 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761000219 ATP binding site [chemical binding]; other site 997761000220 Mg2+ binding site [ion binding]; other site 997761000221 G-X-G motif; other site 997761000222 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761000223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761000224 active site 997761000225 phosphorylation site [posttranslational modification] 997761000226 intermolecular recognition site; other site 997761000227 dimerization interface [polypeptide binding]; other site 997761000228 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761000229 DNA binding residues [nucleotide binding] 997761000230 dimerization interface [polypeptide binding]; other site 997761000231 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 997761000232 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 997761000233 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 997761000234 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 997761000235 ATP binding site [chemical binding]; other site 997761000236 putative Mg++ binding site [ion binding]; other site 997761000237 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 997761000238 nucleotide binding region [chemical binding]; other site 997761000239 ATP-binding site [chemical binding]; other site 997761000240 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 997761000241 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 997761000242 active site 997761000243 flagellar operon protein TIGR03826; Region: YvyF 997761000244 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 997761000245 FlgN protein; Region: FlgN; pfam05130 997761000246 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 997761000247 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 997761000248 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 997761000249 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 997761000250 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 997761000251 carbon storage regulator; Provisional; Region: PRK01712 997761000252 FlaG protein; Region: FlaG; pfam03646 997761000253 flagellar capping protein; Validated; Region: fliD; PRK07737 997761000254 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 997761000255 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 997761000256 Flagellar protein FliS; Region: FliS; cl00654 997761000257 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 997761000258 DNA-binding site [nucleotide binding]; DNA binding site 997761000259 RNA-binding motif; other site 997761000260 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 997761000261 30S subunit binding site; other site 997761000262 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 997761000263 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 997761000264 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 997761000265 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 997761000266 nucleotide binding region [chemical binding]; other site 997761000267 ATP-binding site [chemical binding]; other site 997761000268 SEC-C motif; Region: SEC-C; pfam02810 997761000269 peptide chain release factor 2; Provisional; Region: PRK06746 997761000270 This domain is found in peptide chain release factors; Region: PCRF; smart00937 997761000271 RF-1 domain; Region: RF-1; pfam00472 997761000272 Uncharacterized conserved protein [Function unknown]; Region: COG1284 997761000273 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 997761000274 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 997761000275 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 997761000276 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 997761000277 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 997761000278 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 997761000279 molybdopterin cofactor binding site; other site 997761000280 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 997761000281 molybdopterin cofactor binding site; other site 997761000282 Uncharacterized conserved protein [Function unknown]; Region: COG5609 997761000283 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 997761000284 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 997761000285 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 997761000286 heterotetramer interface [polypeptide binding]; other site 997761000287 active site pocket [active] 997761000288 cleavage site 997761000289 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 997761000290 nucleotide binding site [chemical binding]; other site 997761000291 N-acetyl-L-glutamate binding site [chemical binding]; other site 997761000292 acetylornithine aminotransferase; Provisional; Region: PRK02627 997761000293 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 997761000294 inhibitor-cofactor binding pocket; inhibition site 997761000295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761000296 catalytic residue [active] 997761000297 ornithine carbamoyltransferase; Provisional; Region: PRK00779 997761000298 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 997761000299 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 997761000300 argininosuccinate synthase; Provisional; Region: PRK13820 997761000301 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 997761000302 ANP binding site [chemical binding]; other site 997761000303 Substrate Binding Site II [chemical binding]; other site 997761000304 Substrate Binding Site I [chemical binding]; other site 997761000305 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 997761000306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761000307 Walker A/P-loop; other site 997761000308 ATP binding site [chemical binding]; other site 997761000309 Q-loop/lid; other site 997761000310 ABC transporter signature motif; other site 997761000311 Walker B; other site 997761000312 D-loop; other site 997761000313 H-loop/switch region; other site 997761000314 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 997761000315 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 997761000316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 997761000317 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 997761000318 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 997761000319 Peptidase family M23; Region: Peptidase_M23; pfam01551 997761000320 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 997761000321 C-terminal peptidase (prc); Region: prc; TIGR00225 997761000322 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 997761000323 protein binding site [polypeptide binding]; other site 997761000324 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 997761000325 Catalytic dyad [active] 997761000326 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 997761000327 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 997761000328 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 997761000329 flagellar motor protein MotS; Reviewed; Region: PRK06925 997761000330 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 997761000331 ligand binding site [chemical binding]; other site 997761000332 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 997761000333 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 997761000334 excinuclease ABC subunit B; Provisional; Region: PRK05298 997761000335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 997761000336 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 997761000337 nucleotide binding region [chemical binding]; other site 997761000338 ATP-binding site [chemical binding]; other site 997761000339 Ultra-violet resistance protein B; Region: UvrB; pfam12344 997761000340 UvrB/uvrC motif; Region: UVR; pfam02151 997761000341 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 997761000342 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 997761000343 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 997761000344 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 997761000345 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761000346 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761000347 short chain dehydrogenase; Provisional; Region: PRK08303 997761000348 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761000349 NAD(P) binding site [chemical binding]; other site 997761000350 active site 997761000351 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 997761000352 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 997761000353 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 997761000354 hypothetical protein; Validated; Region: PRK07080 997761000355 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761000356 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 997761000357 Peptidase family U32; Region: Peptidase_U32; pfam01136 997761000358 Collagenase; Region: DUF3656; pfam12392 997761000359 Peptidase family U32; Region: Peptidase_U32; cl03113 997761000360 gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522 997761000361 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 997761000362 Walker A/P-loop; other site 997761000363 ATP binding site [chemical binding]; other site 997761000364 Q-loop/lid; other site 997761000365 ABC transporter signature motif; other site 997761000366 Walker B; other site 997761000367 D-loop; other site 997761000368 H-loop/switch region; other site 997761000369 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 997761000370 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 997761000371 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 997761000372 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 997761000373 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761000374 MarR family; Region: MarR; pfam01047 997761000375 Coat F domain; Region: Coat_F; pfam07875 997761000376 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 997761000377 PcrB family; Region: PcrB; pfam01884 997761000378 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 997761000379 substrate binding site [chemical binding]; other site 997761000380 putative active site [active] 997761000381 dimer interface [polypeptide binding]; other site 997761000382 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 997761000383 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 997761000384 nucleotide binding pocket [chemical binding]; other site 997761000385 K-X-D-G motif; other site 997761000386 catalytic site [active] 997761000387 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 997761000388 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 997761000389 Dimer interface [polypeptide binding]; other site 997761000390 BRCT sequence motif; other site 997761000391 Domain of unknown function (DUF1835); Region: DUF1835; pfam08874 997761000392 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 997761000393 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 997761000394 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 997761000395 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 997761000396 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 997761000397 Walker A/P-loop; other site 997761000398 ATP binding site [chemical binding]; other site 997761000399 Q-loop/lid; other site 997761000400 ABC transporter signature motif; other site 997761000401 Walker B; other site 997761000402 D-loop; other site 997761000403 H-loop/switch region; other site 997761000404 HPr kinase/phosphorylase; Provisional; Region: PRK05428 997761000405 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 997761000406 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 997761000407 Hpr binding site; other site 997761000408 active site 997761000409 homohexamer subunit interaction site [polypeptide binding]; other site 997761000410 pyrophosphatase PpaX; Provisional; Region: PRK13288 997761000411 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761000412 motif II; other site 997761000413 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 997761000414 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 997761000415 trimer interface [polypeptide binding]; other site 997761000416 active site 997761000417 substrate binding site [chemical binding]; other site 997761000418 CoA binding site [chemical binding]; other site 997761000419 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 997761000420 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 997761000421 dimer interface [polypeptide binding]; other site 997761000422 motif 1; other site 997761000423 active site 997761000424 motif 2; other site 997761000425 motif 3; other site 997761000426 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 997761000427 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 997761000428 histidinol dehydrogenase; Region: hisD; TIGR00069 997761000429 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 997761000430 NAD binding site [chemical binding]; other site 997761000431 dimerization interface [polypeptide binding]; other site 997761000432 product binding site; other site 997761000433 substrate binding site [chemical binding]; other site 997761000434 zinc binding site [ion binding]; other site 997761000435 catalytic residues [active] 997761000436 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 997761000437 putative active site pocket [active] 997761000438 4-fold oligomerization interface [polypeptide binding]; other site 997761000439 metal binding residues [ion binding]; metal-binding site 997761000440 3-fold/trimer interface [polypeptide binding]; other site 997761000441 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 997761000442 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 997761000443 putative active site [active] 997761000444 oxyanion strand; other site 997761000445 catalytic triad [active] 997761000446 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 997761000447 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 997761000448 substrate binding site [chemical binding]; other site 997761000449 glutamase interaction surface [polypeptide binding]; other site 997761000450 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 997761000451 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 997761000452 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 997761000453 metal binding site [ion binding]; metal-binding site 997761000454 histidinol-phosphatase; Provisional; Region: PRK07328 997761000455 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 997761000456 active site 997761000457 dimer interface [polypeptide binding]; other site 997761000458 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 997761000459 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 997761000460 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 997761000461 active site 997761000462 TPR repeat; Region: TPR_11; pfam13414 997761000463 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 997761000464 TPR motif; other site 997761000465 binding surface 997761000466 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 997761000467 TPR motif; other site 997761000468 binding surface 997761000469 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 997761000470 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 997761000471 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 997761000472 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 997761000473 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 997761000474 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 997761000475 active site 997761000476 Zn binding site [ion binding]; other site 997761000477 Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201 997761000478 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761000479 Interdomain contacts; other site 997761000480 Cytokine receptor motif; other site 997761000481 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 997761000482 active site 997761000483 catalytic triad [active] 997761000484 oxyanion hole [active] 997761000485 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761000486 Interdomain contacts; other site 997761000487 S-layer homology domain; Region: SLH; pfam00395 997761000488 S-layer homology domain; Region: SLH; pfam00395 997761000489 S-layer homology domain; Region: SLH; pfam00395 997761000490 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 997761000491 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 997761000492 nucleotide binding site [chemical binding]; other site 997761000493 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 997761000494 AAA domain; Region: AAA_33; pfam13671 997761000495 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 997761000496 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 997761000497 phosphate binding site [ion binding]; other site 997761000498 putative substrate binding pocket [chemical binding]; other site 997761000499 dimer interface [polypeptide binding]; other site 997761000500 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 997761000501 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 997761000502 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 997761000503 dimerization domain swap beta strand [polypeptide binding]; other site 997761000504 regulatory protein interface [polypeptide binding]; other site 997761000505 active site 997761000506 regulatory phosphorylation site [posttranslational modification]; other site 997761000507 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761000508 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761000509 Bacterial Ig-like domain; Region: Big_5; pfam13205 997761000510 Clp protease; Region: CLP_protease; pfam00574 997761000511 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 997761000512 oligomer interface [polypeptide binding]; other site 997761000513 active site residues [active] 997761000514 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 997761000515 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 997761000516 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 997761000517 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 997761000518 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 997761000519 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 997761000520 triosephosphate isomerase; Provisional; Region: PRK14565 997761000521 substrate binding site [chemical binding]; other site 997761000522 dimer interface [polypeptide binding]; other site 997761000523 catalytic triad [active] 997761000524 phosphoglyceromutase; Provisional; Region: PRK05434 997761000525 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 997761000526 enolase; Provisional; Region: eno; PRK00077 997761000527 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 997761000528 dimer interface [polypeptide binding]; other site 997761000529 metal binding site [ion binding]; metal-binding site 997761000530 substrate binding pocket [chemical binding]; other site 997761000531 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 997761000532 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 997761000533 Esterase/lipase [General function prediction only]; Region: COG1647 997761000534 Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342 997761000535 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 997761000536 SmpB-tmRNA interface; other site 997761000537 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 997761000538 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 997761000539 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 997761000540 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761000541 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761000542 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 997761000543 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 997761000544 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 997761000545 Helix-turn-helix domain; Region: HTH_18; pfam12833 997761000546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761000547 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 997761000548 putative hydrophobic ligand binding site [chemical binding]; other site 997761000549 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 997761000550 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761000551 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761000552 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761000553 dimerization interface [polypeptide binding]; other site 997761000554 Imelysin; Region: Peptidase_M75; pfam09375 997761000555 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 997761000556 transcriptional antiterminator BglG; Provisional; Region: PRK09772 997761000557 CAT RNA binding domain; Region: CAT_RBD; smart01061 997761000558 PRD domain; Region: PRD; pfam00874 997761000559 PRD domain; Region: PRD; pfam00874 997761000560 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 997761000561 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 997761000562 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 997761000563 active site turn [active] 997761000564 phosphorylation site [posttranslational modification] 997761000565 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 997761000566 HPr interaction site; other site 997761000567 glycerol kinase (GK) interaction site [polypeptide binding]; other site 997761000568 active site 997761000569 phosphorylation site [posttranslational modification] 997761000570 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 997761000571 dimerization domain swap beta strand [polypeptide binding]; other site 997761000572 regulatory protein interface [polypeptide binding]; other site 997761000573 active site 997761000574 regulatory phosphorylation site [posttranslational modification]; other site 997761000575 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 997761000576 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 997761000577 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 997761000578 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 997761000579 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761000580 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761000581 metal binding site [ion binding]; metal-binding site 997761000582 active site 997761000583 I-site; other site 997761000584 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 997761000585 Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679 997761000586 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 997761000587 Hpr binding site; other site 997761000588 active site 997761000589 homohexamer subunit interaction site [polypeptide binding]; other site 997761000590 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 997761000591 extended (e) SDRs; Region: SDR_e; cd08946 997761000592 NAD(P) binding site [chemical binding]; other site 997761000593 active site 997761000594 substrate binding site [chemical binding]; other site 997761000595 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 997761000596 metal-dependent hydrolase; Provisional; Region: PRK13291 997761000597 DinB superfamily; Region: DinB_2; pfam12867 997761000598 short chain dehydrogenase; Provisional; Region: PRK05854 997761000599 retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327 997761000600 putative NAD(P) binding site [chemical binding]; other site 997761000601 active site 997761000602 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 997761000603 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 997761000604 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 997761000605 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 997761000606 GIY-YIG motif/motif A; other site 997761000607 active site 997761000608 catalytic site [active] 997761000609 putative DNA binding site [nucleotide binding]; other site 997761000610 metal binding site [ion binding]; metal-binding site 997761000611 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 997761000612 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 997761000613 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 997761000614 Uncharacterized conserved protein [Function unknown]; Region: COG3339 997761000615 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 997761000616 DNA-binding site [nucleotide binding]; DNA binding site 997761000617 RNA-binding motif; other site 997761000618 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 997761000619 dinuclear metal binding motif [ion binding]; other site 997761000620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761000621 Coenzyme A binding pocket [chemical binding]; other site 997761000622 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761000623 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761000624 dimerization interface [polypeptide binding]; other site 997761000625 Histidine kinase; Region: His_kinase; pfam06580 997761000626 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761000627 ATP binding site [chemical binding]; other site 997761000628 Mg2+ binding site [ion binding]; other site 997761000629 G-X-G motif; other site 997761000630 Response regulator receiver domain; Region: Response_reg; pfam00072 997761000631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761000632 active site 997761000633 phosphorylation site [posttranslational modification] 997761000634 intermolecular recognition site; other site 997761000635 dimerization interface [polypeptide binding]; other site 997761000636 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761000637 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761000638 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761000639 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761000640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761000641 dimer interface [polypeptide binding]; other site 997761000642 conserved gate region; other site 997761000643 ABC-ATPase subunit interface; other site 997761000644 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761000645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761000646 dimer interface [polypeptide binding]; other site 997761000647 ABC-ATPase subunit interface; other site 997761000648 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761000649 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761000650 Fn3 associated; Region: Fn3_assoc; pfam13287 997761000651 Fn3 associated; Region: Fn3_assoc; pfam13287 997761000652 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 997761000653 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 997761000654 putative ligand binding site [chemical binding]; other site 997761000655 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761000656 dimerization interface [polypeptide binding]; other site 997761000657 putative DNA binding site [nucleotide binding]; other site 997761000658 putative Zn2+ binding site [ion binding]; other site 997761000659 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 997761000660 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 997761000661 Walker A/P-loop; other site 997761000662 ATP binding site [chemical binding]; other site 997761000663 Q-loop/lid; other site 997761000664 ABC transporter signature motif; other site 997761000665 Walker B; other site 997761000666 D-loop; other site 997761000667 H-loop/switch region; other site 997761000668 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 997761000669 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 997761000670 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 997761000671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761000672 dimer interface [polypeptide binding]; other site 997761000673 conserved gate region; other site 997761000674 putative PBP binding loops; other site 997761000675 ABC-ATPase subunit interface; other site 997761000676 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 997761000677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761000678 dimer interface [polypeptide binding]; other site 997761000679 conserved gate region; other site 997761000680 putative PBP binding loops; other site 997761000681 ABC-ATPase subunit interface; other site 997761000682 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 997761000683 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 997761000684 Predicted membrane protein (DUF2243); Region: DUF2243; cl01783 997761000685 GAF domain; Region: GAF; pfam01590 997761000686 GAF domain; Region: GAF_2; pfam13185 997761000687 PAS domain S-box; Region: sensory_box; TIGR00229 997761000688 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761000689 putative active site [active] 997761000690 heme pocket [chemical binding]; other site 997761000691 PAS domain S-box; Region: sensory_box; TIGR00229 997761000692 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761000693 putative active site [active] 997761000694 heme pocket [chemical binding]; other site 997761000695 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761000696 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 997761000697 putative active site [active] 997761000698 heme pocket [chemical binding]; other site 997761000699 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761000700 putative active site [active] 997761000701 heme pocket [chemical binding]; other site 997761000702 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761000703 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761000704 metal binding site [ion binding]; metal-binding site 997761000705 active site 997761000706 I-site; other site 997761000707 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 997761000708 Catalytic domain of Protein Kinases; Region: PKc; cd00180 997761000709 active site 997761000710 ATP binding site [chemical binding]; other site 997761000711 substrate binding site [chemical binding]; other site 997761000712 activation loop (A-loop); other site 997761000713 CAAX protease self-immunity; Region: Abi; pfam02517 997761000714 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 997761000715 Predicted integral membrane protein [Function unknown]; Region: COG5658 997761000716 SdpI/YhfL protein family; Region: SdpI; pfam13630 997761000717 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761000718 putative DNA binding site [nucleotide binding]; other site 997761000719 putative Zn2+ binding site [ion binding]; other site 997761000720 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761000721 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761000722 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761000723 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761000724 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 997761000725 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761000726 WHG domain; Region: WHG; pfam13305 997761000727 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 997761000728 Sulfatase; Region: Sulfatase; pfam00884 997761000729 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 997761000730 HTH domain; Region: HTH_11; cl17392 997761000731 HTH domain; Region: HTH_11; pfam08279 997761000732 PRD domain; Region: PRD; pfam00874 997761000733 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 997761000734 active site 997761000735 P-loop; other site 997761000736 phosphorylation site [posttranslational modification] 997761000737 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 997761000738 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 997761000739 active site 997761000740 phosphorylation site [posttranslational modification] 997761000741 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 997761000742 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 997761000743 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 997761000744 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 997761000745 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 997761000746 Zn2+ binding site [ion binding]; other site 997761000747 Mg2+ binding site [ion binding]; other site 997761000748 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 997761000749 transglutaminase; Provisional; Region: tgl; PRK03187 997761000750 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 997761000751 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 997761000752 active site 997761000753 metal binding site [ion binding]; metal-binding site 997761000754 Transcriptional regulators [Transcription]; Region: FadR; COG2186 997761000755 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761000756 DNA-binding site [nucleotide binding]; DNA binding site 997761000757 FCD domain; Region: FCD; pfam07729 997761000758 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 997761000759 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 997761000760 Walker A/P-loop; other site 997761000761 ATP binding site [chemical binding]; other site 997761000762 Q-loop/lid; other site 997761000763 ABC transporter signature motif; other site 997761000764 Walker B; other site 997761000765 D-loop; other site 997761000766 H-loop/switch region; other site 997761000767 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 997761000768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761000769 putative PBP binding loops; other site 997761000770 dimer interface [polypeptide binding]; other site 997761000771 ABC-ATPase subunit interface; other site 997761000772 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 997761000773 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761000774 membrane-bound complex binding site; other site 997761000775 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 997761000776 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761000777 Interdomain contacts; other site 997761000778 Cytokine receptor motif; other site 997761000779 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 997761000780 putative metal binding site [ion binding]; other site 997761000781 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761000782 Interdomain contacts; other site 997761000783 Cytokine receptor motif; other site 997761000784 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 997761000785 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761000786 Interdomain contacts; other site 997761000787 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761000788 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761000789 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761000790 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761000791 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761000792 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 997761000793 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761000794 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761000795 Interdomain contacts; other site 997761000796 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761000797 Interdomain contacts; other site 997761000798 Cytokine receptor motif; other site 997761000799 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 997761000800 catalytic core [active] 997761000801 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 997761000802 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 997761000803 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 997761000804 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 997761000805 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761000806 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 997761000807 putative active site [active] 997761000808 heme pocket [chemical binding]; other site 997761000809 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 997761000810 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761000811 heme pocket [chemical binding]; other site 997761000812 putative active site [active] 997761000813 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761000814 putative active site [active] 997761000815 heme pocket [chemical binding]; other site 997761000816 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 997761000817 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761000818 putative active site [active] 997761000819 heme pocket [chemical binding]; other site 997761000820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761000821 dimer interface [polypeptide binding]; other site 997761000822 phosphorylation site [posttranslational modification] 997761000823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761000824 ATP binding site [chemical binding]; other site 997761000825 Mg2+ binding site [ion binding]; other site 997761000826 G-X-G motif; other site 997761000827 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 997761000828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761000829 active site 997761000830 phosphorylation site [posttranslational modification] 997761000831 intermolecular recognition site; other site 997761000832 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 997761000833 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 997761000834 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 997761000835 YhfH-like protein; Region: YhfH; pfam14149 997761000836 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761000837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761000838 dimer interface [polypeptide binding]; other site 997761000839 phosphorylation site [posttranslational modification] 997761000840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761000841 ATP binding site [chemical binding]; other site 997761000842 Mg2+ binding site [ion binding]; other site 997761000843 G-X-G motif; other site 997761000844 Response regulator receiver domain; Region: Response_reg; pfam00072 997761000845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761000846 active site 997761000847 phosphorylation site [posttranslational modification] 997761000848 intermolecular recognition site; other site 997761000849 dimerization interface [polypeptide binding]; other site 997761000850 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 997761000851 Histidine kinase; Region: HisKA_3; pfam07730 997761000852 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 997761000853 Predicted membrane protein [Function unknown]; Region: COG4818 997761000854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761000855 dimer interface [polypeptide binding]; other site 997761000856 phosphorylation site [posttranslational modification] 997761000857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761000858 ATP binding site [chemical binding]; other site 997761000859 Mg2+ binding site [ion binding]; other site 997761000860 G-X-G motif; other site 997761000861 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 997761000862 dimer interface [polypeptide binding]; other site 997761000863 FMN binding site [chemical binding]; other site 997761000864 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761000865 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761000866 dimerization interface [polypeptide binding]; other site 997761000867 Histidine kinase; Region: His_kinase; pfam06580 997761000868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761000869 ATP binding site [chemical binding]; other site 997761000870 Mg2+ binding site [ion binding]; other site 997761000871 G-X-G motif; other site 997761000872 Response regulator receiver domain; Region: Response_reg; pfam00072 997761000873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761000874 active site 997761000875 phosphorylation site [posttranslational modification] 997761000876 intermolecular recognition site; other site 997761000877 dimerization interface [polypeptide binding]; other site 997761000878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761000879 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761000880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761000881 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 997761000882 EamA-like transporter family; Region: EamA; pfam00892 997761000883 EamA-like transporter family; Region: EamA; pfam00892 997761000884 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 997761000885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761000886 putative substrate translocation pore; other site 997761000887 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761000888 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761000889 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 997761000890 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 997761000891 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761000892 Coenzyme A binding pocket [chemical binding]; other site 997761000893 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 997761000894 Phage Tail Collar Domain; Region: Collar; pfam07484 997761000895 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 997761000896 Phage Tail Collar Domain; Region: Collar; pfam07484 997761000897 Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675 997761000898 Phage Tail Collar Domain; Region: Collar; pfam07484 997761000899 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761000900 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761000901 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 997761000902 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 997761000903 putative active site [active] 997761000904 putative FMN binding site [chemical binding]; other site 997761000905 putative substrate binding site [chemical binding]; other site 997761000906 putative catalytic residue [active] 997761000907 Methyltransferase domain; Region: Methyltransf_23; pfam13489 997761000908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761000909 S-adenosylmethionine binding site [chemical binding]; other site 997761000910 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 997761000911 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761000912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761000913 dimer interface [polypeptide binding]; other site 997761000914 conserved gate region; other site 997761000915 putative PBP binding loops; other site 997761000916 ABC-ATPase subunit interface; other site 997761000917 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761000918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761000919 dimer interface [polypeptide binding]; other site 997761000920 conserved gate region; other site 997761000921 ABC-ATPase subunit interface; other site 997761000922 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761000923 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761000924 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 997761000925 Erythromycin esterase; Region: Erythro_esteras; pfam05139 997761000926 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 997761000927 metal ion-dependent adhesion site (MIDAS); other site 997761000928 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 997761000929 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 997761000930 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761000931 Walker A motif; other site 997761000932 ATP binding site [chemical binding]; other site 997761000933 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 997761000934 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 997761000935 AAA domain; Region: AAA_31; pfam13614 997761000936 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 997761000937 Protein of unknown function (DUF1162); Region: DUF1162; pfam06650 997761000938 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 997761000939 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 997761000940 Walker A motif; other site 997761000941 ATP binding site [chemical binding]; other site 997761000942 Walker B motif; other site 997761000943 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 997761000944 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 997761000945 DctM-like transporters; Region: DctM; pfam06808 997761000946 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 997761000947 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 997761000948 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 997761000949 Cache domain; Region: Cache_1; pfam02743 997761000950 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761000951 dimerization interface [polypeptide binding]; other site 997761000952 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761000953 Histidine kinase; Region: His_kinase; pfam06580 997761000954 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761000955 ATP binding site [chemical binding]; other site 997761000956 Mg2+ binding site [ion binding]; other site 997761000957 G-X-G motif; other site 997761000958 Response regulator receiver domain; Region: Response_reg; pfam00072 997761000959 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761000960 active site 997761000961 phosphorylation site [posttranslational modification] 997761000962 intermolecular recognition site; other site 997761000963 dimerization interface [polypeptide binding]; other site 997761000964 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761000965 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761000966 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761000967 Pectate lyase; Region: Pectate_lyase; pfam03211 997761000968 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 997761000969 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 997761000970 Pectate lyase; Region: Pec_lyase_C; cl01593 997761000971 Leucine rich repeat; Region: LRR_8; pfam13855 997761000972 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 997761000973 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761000974 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761000975 DNA binding residues [nucleotide binding] 997761000976 SnoaL-like domain; Region: SnoaL_2; pfam12680 997761000977 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 997761000978 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 997761000979 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761000980 Coenzyme A binding pocket [chemical binding]; other site 997761000981 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 997761000982 dimer interface [polypeptide binding]; other site 997761000983 FMN binding site [chemical binding]; other site 997761000984 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 997761000985 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 997761000986 P-loop; other site 997761000987 Magnesium ion binding site [ion binding]; other site 997761000988 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 997761000989 Magnesium ion binding site [ion binding]; other site 997761000990 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 997761000991 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 997761000992 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 997761000993 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 997761000994 ATP binding site [chemical binding]; other site 997761000995 putative Mg++ binding site [ion binding]; other site 997761000996 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 997761000997 nucleotide binding region [chemical binding]; other site 997761000998 ATP-binding site [chemical binding]; other site 997761000999 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 997761001000 HRDC domain; Region: HRDC; pfam00570 997761001001 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 997761001002 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 997761001003 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222 997761001004 active site 997761001005 RNA/DNA hybrid binding site [nucleotide binding]; other site 997761001006 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 997761001007 putative hydrolase; Provisional; Region: PRK11460 997761001008 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 997761001009 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 997761001010 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761001011 Zn binding site [ion binding]; other site 997761001012 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 997761001013 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761001014 Zn binding site [ion binding]; other site 997761001015 DoxX; Region: DoxX; pfam07681 997761001016 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761001017 MarR family; Region: MarR; pfam01047 997761001018 MarR family; Region: MarR_2; cl17246 997761001019 Predicted transcriptional regulator [Transcription]; Region: COG2378 997761001020 HTH domain; Region: HTH_11; pfam08279 997761001021 WYL domain; Region: WYL; pfam13280 997761001022 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 997761001023 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 997761001024 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 997761001025 Na2 binding site [ion binding]; other site 997761001026 putative substrate binding site 1 [chemical binding]; other site 997761001027 Na binding site 1 [ion binding]; other site 997761001028 putative substrate binding site 2 [chemical binding]; other site 997761001029 PAS fold; Region: PAS_4; pfam08448 997761001030 PAS domain S-box; Region: sensory_box; TIGR00229 997761001031 PAS domain; Region: PAS; smart00091 997761001032 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761001033 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761001034 metal binding site [ion binding]; metal-binding site 997761001035 active site 997761001036 I-site; other site 997761001037 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 997761001038 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 997761001039 ThiC-associated domain; Region: ThiC-associated; pfam13667 997761001040 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 997761001041 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 997761001042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761001043 Walker A/P-loop; other site 997761001044 ATP binding site [chemical binding]; other site 997761001045 Q-loop/lid; other site 997761001046 ABC transporter signature motif; other site 997761001047 Walker B; other site 997761001048 D-loop; other site 997761001049 H-loop/switch region; other site 997761001050 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761001051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761001052 active site 997761001053 phosphorylation site [posttranslational modification] 997761001054 intermolecular recognition site; other site 997761001055 dimerization interface [polypeptide binding]; other site 997761001056 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761001057 DNA binding site [nucleotide binding] 997761001058 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761001059 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761001060 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761001061 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 997761001062 pyruvate kinase; Provisional; Region: PRK05826 997761001063 domain interfaces; other site 997761001064 active site 997761001065 Protein of unknown function (DUF554); Region: DUF554; pfam04474 997761001066 seryl-tRNA synthetase; Provisional; Region: PRK05431 997761001067 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 997761001068 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 997761001069 dimer interface [polypeptide binding]; other site 997761001070 active site 997761001071 motif 1; other site 997761001072 motif 2; other site 997761001073 motif 3; other site 997761001074 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761001075 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 997761001076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761001077 Walker A/P-loop; other site 997761001078 ATP binding site [chemical binding]; other site 997761001079 Q-loop/lid; other site 997761001080 ABC transporter signature motif; other site 997761001081 Walker B; other site 997761001082 D-loop; other site 997761001083 H-loop/switch region; other site 997761001084 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 997761001085 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761001086 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 997761001087 Walker A/P-loop; other site 997761001088 ATP binding site [chemical binding]; other site 997761001089 Q-loop/lid; other site 997761001090 ABC transporter signature motif; other site 997761001091 Walker B; other site 997761001092 D-loop; other site 997761001093 H-loop/switch region; other site 997761001094 Thiamine pyrophosphokinase; Region: TPK; cd07995 997761001095 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 997761001096 active site 997761001097 dimerization interface [polypeptide binding]; other site 997761001098 thiamine binding site [chemical binding]; other site 997761001099 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 997761001100 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 997761001101 DinB superfamily; Region: DinB_2; pfam12867 997761001102 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 997761001103 Guanylate kinase; Region: Guanylate_kin; pfam00625 997761001104 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 997761001105 active site 997761001106 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 997761001107 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 997761001108 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 997761001109 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 997761001110 Cytochrome c; Region: Cytochrom_C; cl11414 997761001111 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 997761001112 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 997761001113 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 997761001114 D-pathway; other site 997761001115 Putative ubiquinol binding site [chemical binding]; other site 997761001116 Low-spin heme (heme b) binding site [chemical binding]; other site 997761001117 Putative water exit pathway; other site 997761001118 Binuclear center (heme o3/CuB) [ion binding]; other site 997761001119 K-pathway; other site 997761001120 Putative proton exit pathway; other site 997761001121 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 997761001122 Subunit I/III interface [polypeptide binding]; other site 997761001123 Subunit III/IV interface [polypeptide binding]; other site 997761001124 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 997761001125 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173 997761001126 Protein of unknown function (DUF420); Region: DUF420; pfam04238 997761001127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761001128 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 997761001129 Bacterial SH3 domain; Region: SH3_3; pfam08239 997761001130 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 997761001131 NlpC/P60 family; Region: NLPC_P60; pfam00877 997761001132 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 997761001133 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 997761001134 catalytic residues [active] 997761001135 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 997761001136 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 997761001137 Malic enzyme, N-terminal domain; Region: malic; pfam00390 997761001138 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 997761001139 putative NAD(P) binding site [chemical binding]; other site 997761001140 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761001141 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761001142 dimerization interface [polypeptide binding]; other site 997761001143 putative DNA binding site [nucleotide binding]; other site 997761001144 putative Zn2+ binding site [ion binding]; other site 997761001145 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 997761001146 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761001147 FeS/SAM binding site; other site 997761001148 MOSC domain; Region: MOSC; pfam03473 997761001149 4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944 997761001150 active site 997761001151 catalytic residues [active] 997761001152 metal binding site [ion binding]; metal-binding site 997761001153 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 997761001154 nudix motif; other site 997761001155 S-layer homology domain; Region: SLH; pfam00395 997761001156 S-layer homology domain; Region: SLH; pfam00395 997761001157 S-layer homology domain; Region: SLH; pfam00395 997761001158 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 997761001159 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 997761001160 lysophospholipid transporter LplT; Provisional; Region: PRK11195 997761001161 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 997761001162 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 997761001163 putative acyl-acceptor binding pocket; other site 997761001164 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 997761001165 acyl-activating enzyme (AAE) consensus motif; other site 997761001166 AMP binding site [chemical binding]; other site 997761001167 active site 997761001168 CoA binding site [chemical binding]; other site 997761001169 HI0933-like protein; Region: HI0933_like; pfam03486 997761001170 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 997761001171 Site-specific recombinase; Region: SpecificRecomb; cl15411 997761001172 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 997761001173 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 997761001174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761001175 dimerization interface [polypeptide binding]; other site 997761001176 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761001177 dimer interface [polypeptide binding]; other site 997761001178 putative CheW interface [polypeptide binding]; other site 997761001179 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 997761001180 Cation efflux family; Region: Cation_efflux; pfam01545 997761001181 Protein of unknown function (DUF3905); Region: DUF3905; pfam13045 997761001182 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 997761001183 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 997761001184 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 997761001185 homodimer interface [polypeptide binding]; other site 997761001186 NAD binding pocket [chemical binding]; other site 997761001187 ATP binding pocket [chemical binding]; other site 997761001188 Mg binding site [ion binding]; other site 997761001189 active-site loop [active] 997761001190 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 997761001191 dimanganese center [ion binding]; other site 997761001192 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 997761001193 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 997761001194 inhibitor-cofactor binding pocket; inhibition site 997761001195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761001196 catalytic residue [active] 997761001197 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 997761001198 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 997761001199 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761001200 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761001201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761001202 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761001203 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 997761001204 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 997761001205 minor groove reading motif; other site 997761001206 helix-hairpin-helix signature motif; other site 997761001207 substrate binding pocket [chemical binding]; other site 997761001208 active site 997761001209 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 997761001210 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 997761001211 DNA binding and oxoG recognition site [nucleotide binding] 997761001212 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 997761001213 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 997761001214 ligand binding site [chemical binding]; other site 997761001215 flexible hinge region; other site 997761001216 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 997761001217 non-specific DNA interactions [nucleotide binding]; other site 997761001218 DNA binding site [nucleotide binding] 997761001219 sequence specific DNA binding site [nucleotide binding]; other site 997761001220 putative cAMP binding site [chemical binding]; other site 997761001221 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 997761001222 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 997761001223 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 997761001224 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 997761001225 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 997761001226 active site 997761001227 catalytic residues [active] 997761001228 Fn3 associated; Region: Fn3_assoc; pfam13287 997761001229 S-layer homology domain; Region: SLH; pfam00395 997761001230 S-layer homology domain; Region: SLH; pfam00395 997761001231 putative acetyltransferase; Provisional; Region: PRK03624 997761001232 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761001233 Coenzyme A binding pocket [chemical binding]; other site 997761001234 Protein of unknown function (DUF402); Region: DUF402; cl00979 997761001235 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 997761001236 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 997761001237 Catalytic site [active] 997761001238 epoxyqueuosine reductase; Region: TIGR00276 997761001239 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 997761001240 Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500 997761001241 protein binding surface [polypeptide binding]; other site 997761001242 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 997761001243 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 997761001244 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 997761001245 DNA binding site [nucleotide binding] 997761001246 active site 997761001247 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 997761001248 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 997761001249 Zn2+ binding site [ion binding]; other site 997761001250 Mg2+ binding site [ion binding]; other site 997761001251 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 997761001252 homodecamer interface [polypeptide binding]; other site 997761001253 GTP cyclohydrolase I; Provisional; Region: PLN03044 997761001254 active site 997761001255 putative catalytic site residues [active] 997761001256 zinc binding site [ion binding]; other site 997761001257 GTP-CH-I/GFRP interaction surface; other site 997761001258 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 997761001259 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 997761001260 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 997761001261 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 997761001262 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 997761001263 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 997761001264 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 997761001265 Transcriptional regulator [Transcription]; Region: IclR; COG1414 997761001266 Bacterial transcriptional regulator; Region: IclR; pfam01614 997761001267 aconitate hydratase; Validated; Region: PRK09277 997761001268 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 997761001269 substrate binding site [chemical binding]; other site 997761001270 ligand binding site [chemical binding]; other site 997761001271 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 997761001272 substrate binding site [chemical binding]; other site 997761001273 Putative amidase domain; Region: Amidase_6; pfam12671 997761001274 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 997761001275 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 997761001276 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 997761001277 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 997761001278 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594 997761001279 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 997761001280 NAD binding site [chemical binding]; other site 997761001281 homotetramer interface [polypeptide binding]; other site 997761001282 homodimer interface [polypeptide binding]; other site 997761001283 substrate binding site [chemical binding]; other site 997761001284 active site 997761001285 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 997761001286 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 997761001287 active site 997761001288 dimerization interface [polypeptide binding]; other site 997761001289 biotin synthase; Validated; Region: PRK06256 997761001290 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761001291 FeS/SAM binding site; other site 997761001292 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 997761001293 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 997761001294 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 997761001295 substrate-cofactor binding pocket; other site 997761001296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761001297 catalytic residue [active] 997761001298 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 997761001299 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 997761001300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761001301 S-adenosylmethionine binding site [chemical binding]; other site 997761001302 hypothetical protein; Provisional; Region: PHA02939 997761001303 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK12481 997761001304 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 997761001305 NADP binding site [chemical binding]; other site 997761001306 homodimer interface [polypeptide binding]; other site 997761001307 active site 997761001308 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 997761001309 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 997761001310 substrate binding site [chemical binding]; other site 997761001311 ATP binding site [chemical binding]; other site 997761001312 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 997761001313 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 997761001314 active site 997761001315 intersubunit interface [polypeptide binding]; other site 997761001316 catalytic residue [active] 997761001317 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 997761001318 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 997761001319 iron-sulfur cluster [ion binding]; other site 997761001320 [2Fe-2S] cluster binding site [ion binding]; other site 997761001321 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 997761001322 hydrophobic ligand binding site; other site 997761001323 Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067 997761001324 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 997761001325 active site 997761001326 dimer interface [polypeptide binding]; other site 997761001327 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 997761001328 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 997761001329 Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645 997761001330 active site 997761001331 FMN binding site [chemical binding]; other site 997761001332 substrate binding site [chemical binding]; other site 997761001333 3Fe-4S cluster binding site [ion binding]; other site 997761001334 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504 997761001335 domain_subunit interface; other site 997761001336 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 997761001337 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 997761001338 inhibitor-cofactor binding pocket; inhibition site 997761001339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761001340 catalytic residue [active] 997761001341 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 997761001342 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 997761001343 Transcriptional regulator [Transcription]; Region: LytR; COG1316 997761001344 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 997761001345 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 997761001346 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 997761001347 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761001348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761001349 active site 997761001350 phosphorylation site [posttranslational modification] 997761001351 intermolecular recognition site; other site 997761001352 dimerization interface [polypeptide binding]; other site 997761001353 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761001354 DNA binding residues [nucleotide binding] 997761001355 dimerization interface [polypeptide binding]; other site 997761001356 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 997761001357 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 997761001358 catalytic triad [active] 997761001359 glycerate dehydrogenase; Provisional; Region: PRK06487 997761001360 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 997761001361 putative ligand binding site [chemical binding]; other site 997761001362 putative NAD binding site [chemical binding]; other site 997761001363 catalytic site [active] 997761001364 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 997761001365 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 997761001366 NodB motif; other site 997761001367 active site 997761001368 catalytic site [active] 997761001369 Zn binding site [ion binding]; other site 997761001370 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761001371 MoxR-like ATPases [General function prediction only]; Region: COG0714 997761001372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761001373 Walker A motif; other site 997761001374 ATP binding site [chemical binding]; other site 997761001375 Walker B motif; other site 997761001376 arginine finger; other site 997761001377 GMP synthase; Reviewed; Region: guaA; PRK00074 997761001378 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 997761001379 AMP/PPi binding site [chemical binding]; other site 997761001380 candidate oxyanion hole; other site 997761001381 catalytic triad [active] 997761001382 potential glutamine specificity residues [chemical binding]; other site 997761001383 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 997761001384 ATP Binding subdomain [chemical binding]; other site 997761001385 Ligand Binding sites [chemical binding]; other site 997761001386 Dimerization subdomain; other site 997761001387 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 997761001388 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 997761001389 active site 997761001390 Int/Topo IB signature motif; other site 997761001391 DNA binding site [nucleotide binding] 997761001392 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 997761001393 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 997761001394 active site 997761001395 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 997761001396 metal binding site [ion binding]; metal-binding site 997761001397 NUMOD4 motif; Region: NUMOD4; pfam07463 997761001398 HNH endonuclease; Region: HNH_3; pfam13392 997761001399 NUMOD1 domain; Region: NUMOD1; pfam07453 997761001400 multiple promoter invertase; Provisional; Region: mpi; PRK13413 997761001401 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 997761001402 catalytic residues [active] 997761001403 catalytic nucleophile [active] 997761001404 Presynaptic Site I dimer interface [polypeptide binding]; other site 997761001405 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 997761001406 Synaptic Flat tetramer interface [polypeptide binding]; other site 997761001407 Synaptic Site I dimer interface [polypeptide binding]; other site 997761001408 DNA binding site [nucleotide binding] 997761001409 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 997761001410 DNA-binding interface [nucleotide binding]; DNA binding site 997761001411 GMP synthase C terminal domain; Region: GMP_synt_C; pfam00958 997761001412 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 997761001413 2-isopropylmalate synthase; Validated; Region: PRK00915 997761001414 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 997761001415 active site 997761001416 catalytic residues [active] 997761001417 metal binding site [ion binding]; metal-binding site 997761001418 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 997761001419 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 997761001420 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 997761001421 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761001422 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761001423 ABC transporter; Region: ABC_tran_2; pfam12848 997761001424 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761001425 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212 997761001426 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 997761001427 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 997761001428 trimer interface [polypeptide binding]; other site 997761001429 dimer interface [polypeptide binding]; other site 997761001430 putative active site [active] 997761001431 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 997761001432 MPT binding site; other site 997761001433 trimer interface [polypeptide binding]; other site 997761001434 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 997761001435 putative MPT binding site; other site 997761001436 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 997761001437 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 997761001438 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 997761001439 oligomerisation interface [polypeptide binding]; other site 997761001440 mobile loop; other site 997761001441 roof hairpin; other site 997761001442 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 997761001443 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 997761001444 ring oligomerisation interface [polypeptide binding]; other site 997761001445 ATP/Mg binding site [chemical binding]; other site 997761001446 stacking interactions; other site 997761001447 hinge regions; other site 997761001448 SNF2 Helicase protein; Region: DUF3670; pfam12419 997761001449 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 997761001450 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 997761001451 ATP binding site [chemical binding]; other site 997761001452 putative Mg++ binding site [ion binding]; other site 997761001453 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 997761001454 nucleotide binding region [chemical binding]; other site 997761001455 ATP-binding site [chemical binding]; other site 997761001456 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 997761001457 S-layer homology domain; Region: SLH; pfam00395 997761001458 S-layer homology domain; Region: SLH; pfam00395 997761001459 S-layer homology domain; Region: SLH; pfam00395 997761001460 S-layer homology domain; Region: SLH; pfam00395 997761001461 S-layer homology domain; Region: SLH; pfam00395 997761001462 O-Antigen ligase; Region: Wzy_C; pfam04932 997761001463 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 997761001464 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 997761001465 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 997761001466 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 997761001467 Probable Catalytic site; other site 997761001468 metal-binding site 997761001469 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761001470 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 997761001471 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 997761001472 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761001473 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 997761001474 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 997761001475 Ligand binding site; other site 997761001476 Putative Catalytic site; other site 997761001477 DXD motif; other site 997761001478 Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034 997761001479 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 997761001480 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 997761001481 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 997761001482 substrate binding site; other site 997761001483 tetramer interface; other site 997761001484 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 997761001485 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 997761001486 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 997761001487 NAD binding site [chemical binding]; other site 997761001488 substrate binding site [chemical binding]; other site 997761001489 homodimer interface [polypeptide binding]; other site 997761001490 active site 997761001491 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 997761001492 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 997761001493 NADP binding site [chemical binding]; other site 997761001494 active site 997761001495 putative substrate binding site [chemical binding]; other site 997761001496 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 997761001497 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 997761001498 Probable Catalytic site; other site 997761001499 metal-binding site 997761001500 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 997761001501 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 997761001502 Probable Catalytic site; other site 997761001503 metal-binding site 997761001504 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 997761001505 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761001506 Bacterial sugar transferase; Region: Bac_transf; pfam02397 997761001507 alanine racemase; Reviewed; Region: alr; PRK00053 997761001508 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 997761001509 active site 997761001510 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 997761001511 dimer interface [polypeptide binding]; other site 997761001512 substrate binding site [chemical binding]; other site 997761001513 catalytic residues [active] 997761001514 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 997761001515 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864 997761001516 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 997761001517 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 997761001518 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 997761001519 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 997761001520 RNA binding site [nucleotide binding]; other site 997761001521 SprT homologues; Region: SprT; cl01182 997761001522 SprT-like family; Region: SprT-like; pfam10263 997761001523 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 997761001524 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 997761001525 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 997761001526 dimanganese center [ion binding]; other site 997761001527 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 997761001528 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 997761001529 active site 997761001530 catalytic site [active] 997761001531 metal binding site [ion binding]; metal-binding site 997761001532 dimer interface [polypeptide binding]; other site 997761001533 S-layer homology domain; Region: SLH; pfam00395 997761001534 S-layer homology domain; Region: SLH; pfam00395 997761001535 Protein of unknown function (DUF2621); Region: DUF2621; pfam11084 997761001536 endonuclease IV; Provisional; Region: PRK01060 997761001537 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 997761001538 AP (apurinic/apyrimidinic) site pocket; other site 997761001539 DNA interaction; other site 997761001540 Metal-binding active site; metal-binding site 997761001541 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 997761001542 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 997761001543 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 997761001544 putative active site [active] 997761001545 putative substrate binding site [chemical binding]; other site 997761001546 putative cosubstrate binding site; other site 997761001547 catalytic site [active] 997761001548 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 997761001549 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 997761001550 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 997761001551 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 997761001552 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 997761001553 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 997761001554 [2Fe-2S] cluster binding site [ion binding]; other site 997761001555 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 997761001556 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 997761001557 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 997761001558 PilZ domain; Region: PilZ; pfam07238 997761001559 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 997761001560 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 997761001561 active site 997761001562 dimer interface [polypeptide binding]; other site 997761001563 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 997761001564 dimer interface [polypeptide binding]; other site 997761001565 active site 997761001566 Uncharacterized conserved protein [Function unknown]; Region: COG1739 997761001567 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 997761001568 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 997761001569 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761001570 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761001571 WHG domain; Region: WHG; pfam13305 997761001572 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 997761001573 Ribosomal protein L35Ae; Region: Ribosomal_L35Ae; cl01033 997761001574 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 997761001575 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 997761001576 Helix-turn-helix domain; Region: HTH_17; pfam12728 997761001577 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 997761001578 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 997761001579 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 997761001580 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 997761001581 active site 997761001582 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 997761001583 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 997761001584 putative sugar binding sites [chemical binding]; other site 997761001585 Q-X-W motif; other site 997761001586 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 997761001587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761001588 active site 997761001589 phosphorylation site [posttranslational modification] 997761001590 intermolecular recognition site; other site 997761001591 LytTr DNA-binding domain; Region: LytTR; smart00850 997761001592 Response regulator receiver domain; Region: Response_reg; pfam00072 997761001593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761001594 active site 997761001595 phosphorylation site [posttranslational modification] 997761001596 intermolecular recognition site; other site 997761001597 dimerization interface [polypeptide binding]; other site 997761001598 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761001599 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 997761001600 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 997761001601 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 997761001602 GAF domain; Region: GAF_3; pfam13492 997761001603 GAF domain; Region: GAF_2; pfam13185 997761001604 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761001605 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761001606 dimer interface [polypeptide binding]; other site 997761001607 phosphorylation site [posttranslational modification] 997761001608 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761001609 ATP binding site [chemical binding]; other site 997761001610 Mg2+ binding site [ion binding]; other site 997761001611 G-X-G motif; other site 997761001612 alpha-galactosidase; Provisional; Region: PRK15076 997761001613 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 997761001614 NAD binding site [chemical binding]; other site 997761001615 sugar binding site [chemical binding]; other site 997761001616 divalent metal binding site [ion binding]; other site 997761001617 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 997761001618 dimer interface [polypeptide binding]; other site 997761001619 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 997761001620 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 997761001621 methionine sulfoxide reductase A; Provisional; Region: PRK14054 997761001622 methionine sulfoxide reductase B; Provisional; Region: PRK00222 997761001623 SelR domain; Region: SelR; pfam01641 997761001624 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 997761001625 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 997761001626 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761001627 Coenzyme A binding pocket [chemical binding]; other site 997761001628 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 997761001629 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 997761001630 nudix motif; other site 997761001631 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 997761001632 Transcriptional regulators [Transcription]; Region: MarR; COG1846 997761001633 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 997761001634 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 997761001635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761001636 putative substrate translocation pore; other site 997761001637 Uncharacterized conserved protein [Function unknown]; Region: COG3339 997761001638 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 997761001639 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 997761001640 conserved cys residue [active] 997761001641 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 997761001642 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 997761001643 metal binding site [ion binding]; metal-binding site 997761001644 active site 997761001645 Sulfatase; Region: Sulfatase; pfam00884 997761001646 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 997761001647 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 997761001648 RNA binding surface [nucleotide binding]; other site 997761001649 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 997761001650 active site 997761001651 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 997761001652 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 997761001653 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 997761001654 Walker A/P-loop; other site 997761001655 ATP binding site [chemical binding]; other site 997761001656 Q-loop/lid; other site 997761001657 ABC transporter signature motif; other site 997761001658 Walker B; other site 997761001659 D-loop; other site 997761001660 H-loop/switch region; other site 997761001661 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 997761001662 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 997761001663 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 997761001664 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 997761001665 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 997761001666 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761001667 FeS/SAM binding site; other site 997761001668 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 997761001669 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 997761001670 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 997761001671 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761001672 S-adenosylmethionine binding site [chemical binding]; other site 997761001673 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 997761001674 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761001675 FeS/SAM binding site; other site 997761001676 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 997761001677 monogalactosyldiacylglycerol synthase; Region: PLN02605 997761001678 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 997761001679 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 997761001680 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 997761001681 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 997761001682 active site 997761001683 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761001684 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 997761001685 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 997761001686 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 997761001687 DXD motif; other site 997761001688 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 997761001689 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 997761001690 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 997761001691 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 997761001692 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 997761001693 23S rRNA binding site [nucleotide binding]; other site 997761001694 L21 binding site [polypeptide binding]; other site 997761001695 L13 binding site [polypeptide binding]; other site 997761001696 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 997761001697 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 997761001698 active site 997761001699 metal binding site [ion binding]; metal-binding site 997761001700 Domain of unknown function (DUF4073); Region: DUF4073; pfam13285 997761001701 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 997761001702 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 997761001703 PYR/PP interface [polypeptide binding]; other site 997761001704 dimer interface [polypeptide binding]; other site 997761001705 TPP binding site [chemical binding]; other site 997761001706 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 997761001707 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 997761001708 TPP-binding site [chemical binding]; other site 997761001709 dimer interface [polypeptide binding]; other site 997761001710 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 997761001711 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 997761001712 putative valine binding site [chemical binding]; other site 997761001713 dimer interface [polypeptide binding]; other site 997761001714 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 997761001715 ketol-acid reductoisomerase; Provisional; Region: PRK05479 997761001716 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 997761001717 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 997761001718 2-isopropylmalate synthase; Validated; Region: PRK00915 997761001719 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 997761001720 active site 997761001721 catalytic residues [active] 997761001722 metal binding site [ion binding]; metal-binding site 997761001723 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 997761001724 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 997761001725 active site 997761001726 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 997761001727 HAMP domain; Region: HAMP; pfam00672 997761001728 dimerization interface [polypeptide binding]; other site 997761001729 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761001730 dimer interface [polypeptide binding]; other site 997761001731 putative CheW interface [polypeptide binding]; other site 997761001732 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 997761001733 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 997761001734 acyl-activating enzyme (AAE) consensus motif; other site 997761001735 AMP binding site [chemical binding]; other site 997761001736 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761001737 thioester reductase domain; Region: Thioester-redct; TIGR01746 997761001738 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 997761001739 putative NAD(P) binding site [chemical binding]; other site 997761001740 active site 997761001741 putative substrate binding site [chemical binding]; other site 997761001742 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 997761001743 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 997761001744 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761001745 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761001746 homodimer interface [polypeptide binding]; other site 997761001747 catalytic residue [active] 997761001748 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 997761001749 tartrate dehydrogenase; Region: TTC; TIGR02089 997761001750 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 997761001751 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 997761001752 dimer interface [polypeptide binding]; other site 997761001753 decamer (pentamer of dimers) interface [polypeptide binding]; other site 997761001754 catalytic triad [active] 997761001755 peroxidatic and resolving cysteines [active] 997761001756 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 997761001757 lipoyl attachment site [posttranslational modification]; other site 997761001758 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 997761001759 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 997761001760 KTSC domain; Region: KTSC; pfam13619 997761001761 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 997761001762 NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181 997761001763 active site 997761001764 Substrate binding site; other site 997761001765 Mg++ binding site; other site 997761001766 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 997761001767 putative trimer interface [polypeptide binding]; other site 997761001768 putative CoA binding site [chemical binding]; other site 997761001769 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 997761001770 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 997761001771 active site 997761001772 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 997761001773 substrate binding site [chemical binding]; other site 997761001774 metal binding site [ion binding]; metal-binding site 997761001775 Uncharacterized conserved protein [Function unknown]; Region: COG1543 997761001776 N-terminal catalytic domain of alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792 997761001777 active site 997761001778 substrate binding site [chemical binding]; other site 997761001779 catalytic site [active] 997761001780 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 997761001781 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761001782 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 997761001783 putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311 997761001784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761001785 Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791 997761001786 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 997761001787 DinB superfamily; Region: DinB_2; pfam12867 997761001788 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 997761001789 CGNR zinc finger; Region: zf-CGNR; pfam11706 997761001790 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 997761001791 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761001792 active site 997761001793 catalytic tetrad [active] 997761001794 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 997761001795 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761001796 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761001797 PAS domain S-box; Region: sensory_box; TIGR00229 997761001798 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761001799 putative active site [active] 997761001800 heme pocket [chemical binding]; other site 997761001801 PAS fold; Region: PAS_3; pfam08447 997761001802 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 997761001803 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 997761001804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761001805 putative active site [active] 997761001806 heme pocket [chemical binding]; other site 997761001807 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761001808 dimer interface [polypeptide binding]; other site 997761001809 phosphorylation site [posttranslational modification] 997761001810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761001811 ATP binding site [chemical binding]; other site 997761001812 Mg2+ binding site [ion binding]; other site 997761001813 G-X-G motif; other site 997761001814 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 997761001815 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 997761001816 Moco binding site; other site 997761001817 metal coordination site [ion binding]; other site 997761001818 Predicted transcriptional regulator [Transcription]; Region: COG2378 997761001819 HTH domain; Region: HTH_11; pfam08279 997761001820 WYL domain; Region: WYL; pfam13280 997761001821 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 997761001822 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 997761001823 conserved cys residue [active] 997761001824 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 997761001825 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761001826 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761001827 dimer interface [polypeptide binding]; other site 997761001828 putative CheW interface [polypeptide binding]; other site 997761001829 Protein of unknown function, DUF606; Region: DUF606; pfam04657 997761001830 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 997761001831 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 997761001832 ligand binding site [chemical binding]; other site 997761001833 flexible hinge region; other site 997761001834 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 997761001835 Protein of unknown function, DUF606; Region: DUF606; pfam04657 997761001836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761001837 Coenzyme A binding pocket [chemical binding]; other site 997761001838 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761001839 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761001840 dimer interface [polypeptide binding]; other site 997761001841 phosphorylation site [posttranslational modification] 997761001842 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761001843 ATP binding site [chemical binding]; other site 997761001844 Mg2+ binding site [ion binding]; other site 997761001845 G-X-G motif; other site 997761001846 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761001847 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761001848 active site 997761001849 phosphorylation site [posttranslational modification] 997761001850 intermolecular recognition site; other site 997761001851 dimerization interface [polypeptide binding]; other site 997761001852 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761001853 DNA binding site [nucleotide binding] 997761001854 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 997761001855 putative metal binding residues [ion binding]; other site 997761001856 signature motif; other site 997761001857 dimer interface [polypeptide binding]; other site 997761001858 active site 997761001859 polyP binding site; other site 997761001860 substrate binding site [chemical binding]; other site 997761001861 acceptor-phosphate pocket; other site 997761001862 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 997761001863 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 997761001864 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 997761001865 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761001866 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 997761001867 active site 997761001868 oxyanion hole [active] 997761001869 catalytic triad [active] 997761001870 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 997761001871 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761001872 putative substrate translocation pore; other site 997761001873 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761001874 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761001875 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761001876 dimerization interface [polypeptide binding]; other site 997761001877 Histidine kinase; Region: His_kinase; pfam06580 997761001878 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761001879 ATP binding site [chemical binding]; other site 997761001880 Mg2+ binding site [ion binding]; other site 997761001881 G-X-G motif; other site 997761001882 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 997761001883 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 997761001884 ligand binding site [chemical binding]; other site 997761001885 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 997761001886 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 997761001887 DNA binding residues [nucleotide binding] 997761001888 dimer interface [polypeptide binding]; other site 997761001889 Methyltransferase domain; Region: Methyltransf_31; pfam13847 997761001890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761001891 S-adenosylmethionine binding site [chemical binding]; other site 997761001892 IDEAL domain; Region: IDEAL; cl07452 997761001893 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761001894 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761001895 Response regulator receiver domain; Region: Response_reg; pfam00072 997761001896 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761001897 active site 997761001898 phosphorylation site [posttranslational modification] 997761001899 intermolecular recognition site; other site 997761001900 dimerization interface [polypeptide binding]; other site 997761001901 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761001902 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761001903 fructuronate transporter; Provisional; Region: PRK10034; cl15264 997761001904 GntP family permease; Region: GntP_permease; pfam02447 997761001905 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 997761001906 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 997761001907 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 997761001908 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 997761001909 N- and C-terminal domain interface [polypeptide binding]; other site 997761001910 active site 997761001911 catalytic site [active] 997761001912 metal binding site [ion binding]; metal-binding site 997761001913 carbohydrate binding site [chemical binding]; other site 997761001914 ATP binding site [chemical binding]; other site 997761001915 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 997761001916 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 997761001917 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 997761001918 NAD binding site [chemical binding]; other site 997761001919 catalytic Zn binding site [ion binding]; other site 997761001920 structural Zn binding site [ion binding]; other site 997761001921 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 997761001922 Coat F domain; Region: Coat_F; pfam07875 997761001923 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761001924 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761001925 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 997761001926 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 997761001927 Protein of unknown function (DUF418); Region: DUF418; cl12135 997761001928 PhoD-like phosphatase; Region: PhoD; pfam09423 997761001929 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 997761001930 putative active site [active] 997761001931 putative metal binding site [ion binding]; other site 997761001932 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 997761001933 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 997761001934 classical (c) SDRs; Region: SDR_c; cd05233 997761001935 NAD(P) binding site [chemical binding]; other site 997761001936 active site 997761001937 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 997761001938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761001939 DNA-binding site [nucleotide binding]; DNA binding site 997761001940 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761001941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761001942 homodimer interface [polypeptide binding]; other site 997761001943 catalytic residue [active] 997761001944 Lysine efflux permease [General function prediction only]; Region: COG1279 997761001945 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761001946 dimer interface [polypeptide binding]; other site 997761001947 putative CheW interface [polypeptide binding]; other site 997761001948 amino acid transporter; Region: 2A0306; TIGR00909 997761001949 urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425 997761001950 urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424 997761001951 Domain of unknown function (DUF1989); Region: DUF1989; pfam09347 997761001952 allophanate hydrolase; Provisional; Region: PRK08186 997761001953 Amidase; Region: Amidase; cl11426 997761001954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761001955 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 997761001956 putative substrate translocation pore; other site 997761001957 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 997761001958 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 997761001959 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 997761001960 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 997761001961 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 997761001962 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 997761001963 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 997761001964 [4Fe-4S] binding site [ion binding]; other site 997761001965 molybdopterin cofactor binding site; other site 997761001966 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 997761001967 molybdopterin cofactor binding site; other site 997761001968 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761001969 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 997761001970 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 997761001971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 997761001972 Histidine kinase; Region: HisKA_3; pfam07730 997761001973 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 997761001974 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761001975 Response regulator receiver domain; Region: Response_reg; pfam00072 997761001976 active site 997761001977 phosphorylation site [posttranslational modification] 997761001978 intermolecular recognition site; other site 997761001979 dimerization interface [polypeptide binding]; other site 997761001980 YcbB domain; Region: YcbB; pfam08664 997761001981 Amb_all domain; Region: Amb_all; smart00656 997761001982 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761001983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761001984 dimer interface [polypeptide binding]; other site 997761001985 conserved gate region; other site 997761001986 ABC-ATPase subunit interface; other site 997761001987 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761001988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761001989 dimer interface [polypeptide binding]; other site 997761001990 conserved gate region; other site 997761001991 putative PBP binding loops; other site 997761001992 ABC-ATPase subunit interface; other site 997761001993 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761001994 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 997761001995 Sodium Bile acid symporter family; Region: SBF; cl17470 997761001996 S-layer homology domain; Region: SLH; pfam00395 997761001997 S-layer homology domain; Region: SLH; pfam00395 997761001998 S-layer homology domain; Region: SLH; pfam00395 997761001999 Spore germination protein; Region: Spore_permease; cl17796 997761002000 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761002001 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761002002 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761002003 YCII-related domain; Region: YCII; cl00999 997761002004 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 997761002005 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 997761002006 putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265 997761002007 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761002008 Walker A/P-loop; other site 997761002009 ATP binding site [chemical binding]; other site 997761002010 Q-loop/lid; other site 997761002011 ABC transporter signature motif; other site 997761002012 Walker B; other site 997761002013 D-loop; other site 997761002014 H-loop/switch region; other site 997761002015 TOBE domain; Region: TOBE_2; pfam08402 997761002016 putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262 997761002017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002018 dimer interface [polypeptide binding]; other site 997761002019 conserved gate region; other site 997761002020 putative PBP binding loops; other site 997761002021 ABC-ATPase subunit interface; other site 997761002022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002023 dimer interface [polypeptide binding]; other site 997761002024 conserved gate region; other site 997761002025 putative PBP binding loops; other site 997761002026 ABC-ATPase subunit interface; other site 997761002027 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 997761002028 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761002029 motif II; other site 997761002030 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 997761002031 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 997761002032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 997761002033 catalytic residue [active] 997761002034 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 997761002035 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 997761002036 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 997761002037 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 997761002038 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 997761002039 flagellar motor protein MotA; Validated; Region: PRK08124 997761002040 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 997761002041 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 997761002042 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 997761002043 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 997761002044 ligand binding site [chemical binding]; other site 997761002045 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 997761002046 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 997761002047 putative active site [active] 997761002048 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 997761002049 metal ion-dependent adhesion site (MIDAS); other site 997761002050 Tubulin like; Region: Tubulin_2; pfam13809 997761002051 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 997761002052 metal ion-dependent adhesion site (MIDAS); other site 997761002053 PAS fold; Region: PAS_4; pfam08448 997761002054 PAS domain S-box; Region: sensory_box; TIGR00229 997761002055 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761002056 putative active site [active] 997761002057 heme pocket [chemical binding]; other site 997761002058 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761002059 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761002060 metal binding site [ion binding]; metal-binding site 997761002061 active site 997761002062 I-site; other site 997761002063 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 997761002064 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761002065 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761002066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761002067 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761002068 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 997761002069 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761002070 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761002071 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761002072 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 997761002073 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 997761002074 Ligand Binding Site [chemical binding]; other site 997761002075 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 997761002076 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 997761002077 ligand binding site [chemical binding]; other site 997761002078 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 997761002079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761002080 Walker A/P-loop; other site 997761002081 ATP binding site [chemical binding]; other site 997761002082 Q-loop/lid; other site 997761002083 ABC transporter signature motif; other site 997761002084 Walker B; other site 997761002085 D-loop; other site 997761002086 H-loop/switch region; other site 997761002087 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 997761002088 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761002089 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 997761002090 TM-ABC transporter signature motif; other site 997761002091 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761002092 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 997761002093 TM-ABC transporter signature motif; other site 997761002094 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 997761002095 active site 997761002096 NTP binding site [chemical binding]; other site 997761002097 metal binding triad [ion binding]; metal-binding site 997761002098 antibiotic binding site [chemical binding]; other site 997761002099 Methyltransferase domain; Region: Methyltransf_23; pfam13489 997761002100 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761002101 S-adenosylmethionine binding site [chemical binding]; other site 997761002102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761002103 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761002104 putative substrate translocation pore; other site 997761002105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761002106 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 997761002107 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 997761002108 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 997761002109 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 997761002110 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761002111 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 997761002112 motif II; other site 997761002113 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761002114 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761002115 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761002116 metal binding site [ion binding]; metal-binding site 997761002117 active site 997761002118 I-site; other site 997761002119 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 997761002120 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 997761002121 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 997761002122 Zn2+ binding site [ion binding]; other site 997761002123 Mg2+ binding site [ion binding]; other site 997761002124 S-layer homology domain; Region: SLH; pfam00395 997761002125 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 997761002126 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 997761002127 active site 997761002128 metal binding site [ion binding]; metal-binding site 997761002129 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 997761002130 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 997761002131 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 997761002132 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761002133 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761002134 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 997761002135 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 997761002136 putative active site [active] 997761002137 metal binding site [ion binding]; metal-binding site 997761002138 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 997761002139 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 997761002140 putative trimer interface [polypeptide binding]; other site 997761002141 putative CoA binding site [chemical binding]; other site 997761002142 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 997761002143 Bacterial sugar transferase; Region: Bac_transf; pfam02397 997761002144 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 997761002145 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 997761002146 active site 997761002147 tetramer interface; other site 997761002148 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 997761002149 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 997761002150 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 997761002151 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 997761002152 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 997761002153 dimer interface [polypeptide binding]; other site 997761002154 active site 997761002155 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 997761002156 Ligand Binding Site [chemical binding]; other site 997761002157 Molecular Tunnel; other site 997761002158 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 997761002159 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 997761002160 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 997761002161 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 997761002162 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 997761002163 Chain length determinant protein; Region: Wzz; cl15801 997761002164 thymidylate synthase; Reviewed; Region: thyA; PRK01827 997761002165 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 997761002166 dimerization interface [polypeptide binding]; other site 997761002167 active site 997761002168 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 997761002169 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 997761002170 folate binding site [chemical binding]; other site 997761002171 NADP+ binding site [chemical binding]; other site 997761002172 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761002173 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761002174 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761002175 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761002176 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 997761002177 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761002178 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 997761002179 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 997761002180 DXD motif; other site 997761002181 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 997761002182 hypothetical protein; Provisional; Region: PRK10621 997761002183 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 997761002184 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761002185 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 997761002186 active site 997761002187 metal binding site [ion binding]; metal-binding site 997761002188 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 997761002189 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 997761002190 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 997761002191 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 997761002192 NAD binding site [chemical binding]; other site 997761002193 active site 997761002194 nicotinate phosphoribosyltransferase; Region: PLN02885 997761002195 mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486 997761002196 Spore germination protein; Region: Spore_permease; cl17796 997761002197 Spore germination protein; Region: Spore_permease; cl17796 997761002198 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761002199 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761002200 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761002201 HPP family; Region: HPP; pfam04982 997761002202 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761002203 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761002204 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761002205 dimerization interface [polypeptide binding]; other site 997761002206 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 997761002207 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 997761002208 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761002209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002210 dimer interface [polypeptide binding]; other site 997761002211 conserved gate region; other site 997761002212 ABC-ATPase subunit interface; other site 997761002213 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761002214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002215 dimer interface [polypeptide binding]; other site 997761002216 conserved gate region; other site 997761002217 putative PBP binding loops; other site 997761002218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761002219 ABC-ATPase subunit interface; other site 997761002220 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761002221 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761002222 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 997761002223 chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214 997761002224 Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979 997761002225 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761002226 Interdomain contacts; other site 997761002227 Cytokine receptor motif; other site 997761002228 Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325 997761002229 The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548 997761002230 active site 997761002231 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761002232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002233 dimer interface [polypeptide binding]; other site 997761002234 conserved gate region; other site 997761002235 putative PBP binding loops; other site 997761002236 ABC-ATPase subunit interface; other site 997761002237 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761002238 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002239 dimer interface [polypeptide binding]; other site 997761002240 putative PBP binding loops; other site 997761002241 ABC-ATPase subunit interface; other site 997761002242 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 997761002243 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 997761002244 AAA domain; Region: AAA_31; pfam13614 997761002245 Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630 997761002246 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 997761002247 Walker A motif; other site 997761002248 ATP binding site [chemical binding]; other site 997761002249 Walker B motif; other site 997761002250 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 997761002251 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 997761002252 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 997761002253 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 997761002254 active site 997761002255 metal-dependent hydrolase; Provisional; Region: PRK13291 997761002256 DinB superfamily; Region: DinB_2; pfam12867 997761002257 DinB superfamily; Region: DinB_2; pfam12867 997761002258 Protein of unknown function (DUF664); Region: DUF664; pfam04978 997761002259 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761002260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761002261 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761002262 dimerization interface [polypeptide binding]; other site 997761002263 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 997761002264 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 997761002265 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 997761002266 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 997761002267 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 997761002268 GatB domain; Region: GatB_Yqey; smart00845 997761002269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761002270 Coenzyme A binding pocket [chemical binding]; other site 997761002271 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 997761002272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 997761002273 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 997761002274 MgtC family; Region: MgtC; pfam02308 997761002275 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 997761002276 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761002277 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 997761002278 DNA binding residues [nucleotide binding] 997761002279 Putative zinc-finger; Region: zf-HC2; pfam13490 997761002280 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 997761002281 Uncharacterized conserved protein [Function unknown]; Region: COG3595 997761002282 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 997761002283 ferric uptake regulator; Provisional; Region: fur; PRK09462 997761002284 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 997761002285 metal binding site 2 [ion binding]; metal-binding site 997761002286 putative DNA binding helix; other site 997761002287 metal binding site 1 [ion binding]; metal-binding site 997761002288 dimer interface [polypeptide binding]; other site 997761002289 structural Zn2+ binding site [ion binding]; other site 997761002290 Bacterial SH3 domain; Region: SH3_3; pfam08239 997761002291 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 997761002292 active site 997761002293 Protein of unknown function (DUF2614); Region: DUF2614; cl07936 997761002294 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 997761002295 thiS-thiF/thiG interaction site; other site 997761002296 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 997761002297 ThiS interaction site; other site 997761002298 putative active site [active] 997761002299 tetramer interface [polypeptide binding]; other site 997761002300 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 997761002301 active site 997761002302 catalytic triad [active] 997761002303 oxyanion hole [active] 997761002304 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 997761002305 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 997761002306 NodB motif; other site 997761002307 active site 997761002308 catalytic site [active] 997761002309 metal binding site [ion binding]; metal-binding site 997761002310 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 997761002311 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 997761002312 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 997761002313 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 997761002314 Moco binding site; other site 997761002315 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 997761002316 metal coordination site [ion binding]; other site 997761002317 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 997761002318 MOSC domain; Region: MOSC; pfam03473 997761002319 3-alpha domain; Region: 3-alpha; pfam03475 997761002320 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 997761002321 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 997761002322 GTP binding site; other site 997761002323 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 997761002324 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761002325 FeS/SAM binding site; other site 997761002326 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 997761002327 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 997761002328 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 997761002329 dimer interface [polypeptide binding]; other site 997761002330 putative functional site; other site 997761002331 putative MPT binding site; other site 997761002332 Bacterial SH3 domain homologues; Region: SH3b; smart00287 997761002333 Src Homology 3 domain superfamily; Region: SH3; cd00174 997761002334 Bacterial SH3 domain; Region: SH3_3; pfam08239 997761002335 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 997761002336 NlpC/P60 family; Region: NLPC_P60; cl17555 997761002337 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761002338 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761002339 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 997761002340 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761002341 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761002342 DNA binding residues [nucleotide binding] 997761002343 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 997761002344 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 997761002345 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761002346 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761002347 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761002348 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 997761002349 active site 997761002350 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761002351 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 997761002352 active site 997761002353 metal binding site [ion binding]; metal-binding site 997761002354 phage shock protein A; Region: phageshock_pspA; TIGR02977 997761002355 PspC domain; Region: PspC; pfam04024 997761002356 PspA/IM30 family; Region: PspA_IM30; pfam04012 997761002357 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 997761002358 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 997761002359 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761002360 dimerization interface [polypeptide binding]; other site 997761002361 Histidine kinase; Region: HisKA_3; pfam07730 997761002362 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761002363 ATP binding site [chemical binding]; other site 997761002364 Mg2+ binding site [ion binding]; other site 997761002365 G-X-G motif; other site 997761002366 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761002367 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761002368 active site 997761002369 phosphorylation site [posttranslational modification] 997761002370 intermolecular recognition site; other site 997761002371 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761002372 DNA binding residues [nucleotide binding] 997761002373 dimerization interface [polypeptide binding]; other site 997761002374 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761002375 Coenzyme A binding pocket [chemical binding]; other site 997761002376 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 997761002377 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 997761002378 sugar binding site [chemical binding]; other site 997761002379 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 997761002380 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 997761002381 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761002382 Interdomain contacts; other site 997761002383 S-layer homology domain; Region: SLH; pfam00395 997761002384 S-layer homology domain; Region: SLH; pfam00395 997761002385 S-layer homology domain; Region: SLH; pfam00395 997761002386 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 997761002387 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 997761002388 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 997761002389 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 997761002390 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 997761002391 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 997761002392 active site 997761002393 metal binding site [ion binding]; metal-binding site 997761002394 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761002395 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 997761002396 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 997761002397 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761002398 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761002399 DNA binding site [nucleotide binding] 997761002400 domain linker motif; other site 997761002401 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 997761002402 dimerization interface [polypeptide binding]; other site 997761002403 ligand binding site [chemical binding]; other site 997761002404 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761002405 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761002406 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761002407 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 997761002408 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761002409 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761002410 Small, acid-soluble spore protein I; Region: SSPI; cl07940 997761002411 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 997761002412 TrkA-N domain; Region: TrkA_N; pfam02254 997761002413 TrkA-C domain; Region: TrkA_C; pfam02080 997761002414 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 997761002415 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 997761002416 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 997761002417 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 997761002418 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761002419 MarR family; Region: MarR_2; pfam12802 997761002420 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761002421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761002422 active site 997761002423 phosphorylation site [posttranslational modification] 997761002424 intermolecular recognition site; other site 997761002425 dimerization interface [polypeptide binding]; other site 997761002426 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761002427 DNA binding site [nucleotide binding] 997761002428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761002429 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761002430 dimerization interface [polypeptide binding]; other site 997761002431 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761002432 dimer interface [polypeptide binding]; other site 997761002433 phosphorylation site [posttranslational modification] 997761002434 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761002435 ATP binding site [chemical binding]; other site 997761002436 Mg2+ binding site [ion binding]; other site 997761002437 G-X-G motif; other site 997761002438 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 997761002439 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 997761002440 Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122 997761002441 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 997761002442 dimerization interface [polypeptide binding]; other site 997761002443 putative transporter; Provisional; Region: PRK10054 997761002444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761002445 putative substrate translocation pore; other site 997761002446 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 997761002447 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 997761002448 putative active site [active] 997761002449 catalytic site [active] 997761002450 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 997761002451 putative active site [active] 997761002452 catalytic site [active] 997761002453 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 997761002454 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 997761002455 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 997761002456 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 997761002457 Walker A/P-loop; other site 997761002458 ATP binding site [chemical binding]; other site 997761002459 Q-loop/lid; other site 997761002460 ABC transporter signature motif; other site 997761002461 Walker B; other site 997761002462 D-loop; other site 997761002463 H-loop/switch region; other site 997761002464 cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454 997761002465 cobalt transport protein CbiN; Provisional; Region: PRK02898 997761002466 cobalt transport protein CbiM; Validated; Region: PRK08319 997761002467 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 997761002468 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518 997761002469 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 997761002470 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 997761002471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002472 dimer interface [polypeptide binding]; other site 997761002473 conserved gate region; other site 997761002474 putative PBP binding loops; other site 997761002475 ABC-ATPase subunit interface; other site 997761002476 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 997761002477 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 997761002478 Walker A/P-loop; other site 997761002479 ATP binding site [chemical binding]; other site 997761002480 Q-loop/lid; other site 997761002481 ABC transporter signature motif; other site 997761002482 Walker B; other site 997761002483 D-loop; other site 997761002484 H-loop/switch region; other site 997761002485 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 997761002486 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761002487 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761002488 DNA binding site [nucleotide binding] 997761002489 domain linker motif; other site 997761002490 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 997761002491 dimerization interface [polypeptide binding]; other site 997761002492 ligand binding site [chemical binding]; other site 997761002493 sodium binding site [ion binding]; other site 997761002494 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761002495 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761002496 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002497 dimer interface [polypeptide binding]; other site 997761002498 conserved gate region; other site 997761002499 putative PBP binding loops; other site 997761002500 ABC-ATPase subunit interface; other site 997761002501 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761002502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002503 dimer interface [polypeptide binding]; other site 997761002504 conserved gate region; other site 997761002505 putative PBP binding loops; other site 997761002506 ABC-ATPase subunit interface; other site 997761002507 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 997761002508 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 997761002509 substrate binding [chemical binding]; other site 997761002510 active site 997761002511 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 997761002512 azoreductase; Reviewed; Region: PRK00170 997761002513 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 997761002514 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761002515 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761002516 active site 997761002517 catalytic tetrad [active] 997761002518 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 997761002519 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 997761002520 catalytic residues [active] 997761002521 AAA ATPase domain; Region: AAA_16; pfam13191 997761002522 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761002523 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761002524 DNA binding residues [nucleotide binding] 997761002525 dimerization interface [polypeptide binding]; other site 997761002526 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 997761002527 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 997761002528 PYR/PP interface [polypeptide binding]; other site 997761002529 dimer interface [polypeptide binding]; other site 997761002530 TPP binding site [chemical binding]; other site 997761002531 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 997761002532 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 997761002533 TPP-binding site [chemical binding]; other site 997761002534 dimer interface [polypeptide binding]; other site 997761002535 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 997761002536 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 997761002537 putative valine binding site [chemical binding]; other site 997761002538 dimer interface [polypeptide binding]; other site 997761002539 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 997761002540 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761002541 dimerization interface [polypeptide binding]; other site 997761002542 putative DNA binding site [nucleotide binding]; other site 997761002543 putative Zn2+ binding site [ion binding]; other site 997761002544 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761002545 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761002546 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761002547 dimerization interface [polypeptide binding]; other site 997761002548 DinB superfamily; Region: DinB_2; pfam12867 997761002549 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 997761002550 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 997761002551 Peptidase family M23; Region: Peptidase_M23; pfam01551 997761002552 Protein of unknown function DUF111; Region: DUF111; cl03398 997761002553 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 997761002554 AIR carboxylase; Region: AIRC; smart01001 997761002555 lipoyl synthase; Provisional; Region: PRK05481 997761002556 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761002557 FeS/SAM binding site; other site 997761002558 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 997761002559 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 997761002560 ATP-NAD kinase; Region: NAD_kinase; pfam01513 997761002561 PilZ domain; Region: PilZ; pfam07238 997761002562 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 997761002563 putative homodimer interface [polypeptide binding]; other site 997761002564 putative active site pocket [active] 997761002565 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 997761002566 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 997761002567 Nucleoside recognition; Region: Gate; pfam07670 997761002568 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 997761002569 apolar tunnel; other site 997761002570 heme binding site [chemical binding]; other site 997761002571 dimerization interface [polypeptide binding]; other site 997761002572 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 997761002573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 997761002574 YycC-like protein; Region: YycC; pfam14174 997761002575 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 997761002576 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 997761002577 active site 997761002578 Zn binding site [ion binding]; other site 997761002579 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 997761002580 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761002581 dimer interface [polypeptide binding]; other site 997761002582 putative metal binding site [ion binding]; other site 997761002583 General stress protein [General function prediction only]; Region: GsiB; COG3729 997761002584 General stress protein [General function prediction only]; Region: GsiB; COG3729 997761002585 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 997761002586 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 997761002587 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 997761002588 putative active site [active] 997761002589 putative metal binding site [ion binding]; other site 997761002590 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 997761002591 active site 997761002592 catalytic residues [active] 997761002593 Domain of unknown function (DUF1980); Region: DUF1980; pfam09323 997761002594 TIGR03943 family protein; Region: TIGR03943 997761002595 Predicted permease; Region: DUF318; cl17795 997761002596 Predicted permease; Region: DUF318; cl17795 997761002597 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 997761002598 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 997761002599 active site 997761002600 HIGH motif; other site 997761002601 dimer interface [polypeptide binding]; other site 997761002602 KMSKS motif; other site 997761002603 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 997761002604 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 997761002605 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 997761002606 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761002607 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761002608 Walker A/P-loop; other site 997761002609 ATP binding site [chemical binding]; other site 997761002610 Q-loop/lid; other site 997761002611 ABC transporter signature motif; other site 997761002612 Walker B; other site 997761002613 D-loop; other site 997761002614 H-loop/switch region; other site 997761002615 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 997761002616 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761002617 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 997761002618 Walker A/P-loop; other site 997761002619 ATP binding site [chemical binding]; other site 997761002620 Q-loop/lid; other site 997761002621 ABC transporter signature motif; other site 997761002622 Walker B; other site 997761002623 D-loop; other site 997761002624 H-loop/switch region; other site 997761002625 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761002626 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761002627 DNA binding site [nucleotide binding] 997761002628 domain linker motif; other site 997761002629 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 997761002630 dimerization interface [polypeptide binding]; other site 997761002631 ligand binding site [chemical binding]; other site 997761002632 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761002633 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761002634 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761002635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002636 dimer interface [polypeptide binding]; other site 997761002637 conserved gate region; other site 997761002638 putative PBP binding loops; other site 997761002639 ABC-ATPase subunit interface; other site 997761002640 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761002641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002642 dimer interface [polypeptide binding]; other site 997761002643 conserved gate region; other site 997761002644 putative PBP binding loops; other site 997761002645 ABC-ATPase subunit interface; other site 997761002646 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 997761002647 Response regulator receiver domain; Region: Response_reg; pfam00072 997761002648 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761002649 active site 997761002650 phosphorylation site [posttranslational modification] 997761002651 intermolecular recognition site; other site 997761002652 dimerization interface [polypeptide binding]; other site 997761002653 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761002654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761002655 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761002656 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761002657 dimerization interface [polypeptide binding]; other site 997761002658 Histidine kinase; Region: His_kinase; pfam06580 997761002659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761002660 ATP binding site [chemical binding]; other site 997761002661 Mg2+ binding site [ion binding]; other site 997761002662 G-X-G motif; other site 997761002663 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 997761002664 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 997761002665 active site 997761002666 active site 997761002667 catalytic residues [active] 997761002668 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 997761002669 Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509 997761002670 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761002671 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 997761002672 E-class dimer interface [polypeptide binding]; other site 997761002673 P-class dimer interface [polypeptide binding]; other site 997761002674 active site 997761002675 Cu2+ binding site [ion binding]; other site 997761002676 Zn2+ binding site [ion binding]; other site 997761002677 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 997761002678 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 997761002679 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 997761002680 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 997761002681 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 997761002682 NAD binding site [chemical binding]; other site 997761002683 dimer interface [polypeptide binding]; other site 997761002684 substrate binding site [chemical binding]; other site 997761002685 tetramer (dimer of dimers) interface [polypeptide binding]; other site 997761002686 Acyltransferase family; Region: Acyl_transf_3; pfam01757 997761002687 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 997761002688 DinB superfamily; Region: DinB_2; pfam12867 997761002689 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 997761002690 short chain dehydrogenase; Provisional; Region: PRK06914 997761002691 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 997761002692 NADP binding site [chemical binding]; other site 997761002693 active site 997761002694 steroid binding site; other site 997761002695 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761002696 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761002697 active site 997761002698 catalytic tetrad [active] 997761002699 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 997761002700 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 997761002701 TM-ABC transporter signature motif; other site 997761002702 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 997761002703 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761002704 TM-ABC transporter signature motif; other site 997761002705 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 997761002706 alpha-gamma subunit interface [polypeptide binding]; other site 997761002707 beta-gamma subunit interface [polypeptide binding]; other site 997761002708 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 997761002709 gamma-beta subunit interface [polypeptide binding]; other site 997761002710 alpha-beta subunit interface [polypeptide binding]; other site 997761002711 urease subunit alpha; Reviewed; Region: ureC; PRK13207 997761002712 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 997761002713 subunit interactions [polypeptide binding]; other site 997761002714 active site 997761002715 flap region; other site 997761002716 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 997761002717 UreF; Region: UreF; pfam01730 997761002718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761002719 Walker A motif; other site 997761002720 ATP binding site [chemical binding]; other site 997761002721 arginine finger; other site 997761002722 UreD urease accessory protein; Region: UreD; cl00530 997761002723 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 997761002724 UbiA prenyltransferase family; Region: UbiA; pfam01040 997761002725 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 997761002726 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 997761002727 Cu(I) binding site [ion binding]; other site 997761002728 Predicted permeases [General function prediction only]; Region: COG0679 997761002729 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 997761002730 active site 997761002731 metal binding site [ion binding]; metal-binding site 997761002732 S-layer homology domain; Region: SLH; pfam00395 997761002733 S-layer homology domain; Region: SLH; pfam00395 997761002734 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 997761002735 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 997761002736 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 997761002737 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 997761002738 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 997761002739 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 997761002740 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 997761002741 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 997761002742 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 997761002743 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 997761002744 intersubunit interface [polypeptide binding]; other site 997761002745 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 997761002746 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 997761002747 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 997761002748 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761002749 dimer interface [polypeptide binding]; other site 997761002750 ABC-ATPase subunit interface; other site 997761002751 putative PBP binding regions; other site 997761002752 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 997761002753 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761002754 ABC-ATPase subunit interface; other site 997761002755 dimer interface [polypeptide binding]; other site 997761002756 putative PBP binding regions; other site 997761002757 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 997761002758 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 997761002759 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 997761002760 active site 997761002761 dimer interface [polypeptide binding]; other site 997761002762 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 997761002763 Ligand Binding Site [chemical binding]; other site 997761002764 Molecular Tunnel; other site 997761002765 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 997761002766 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761002767 Protein of unknown function (DUF456); Region: DUF456; pfam04306 997761002768 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 997761002769 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 997761002770 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 997761002771 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 997761002772 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 997761002773 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 997761002774 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 997761002775 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 997761002776 catalytic residues [active] 997761002777 EamA-like transporter family; Region: EamA; pfam00892 997761002778 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 997761002779 EamA-like transporter family; Region: EamA; pfam00892 997761002780 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 997761002781 classical (c) SDRs; Region: SDR_c; cd05233 997761002782 NAD(P) binding site [chemical binding]; other site 997761002783 active site 997761002784 NifU-like domain; Region: NifU; cl00484 997761002785 hypothetical protein; Provisional; Region: PRK13669 997761002786 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 997761002787 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 997761002788 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 997761002789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761002790 FeS/SAM binding site; other site 997761002791 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 997761002792 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 997761002793 Tic20-like protein; Region: Tic20; pfam09685 997761002794 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 997761002795 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 997761002796 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 997761002797 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 997761002798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 997761002799 putative heme peroxidase; Provisional; Region: PRK12276 997761002800 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 997761002801 primosomal protein DnaI; Reviewed; Region: PRK08939 997761002802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761002803 Walker A motif; other site 997761002804 ATP binding site [chemical binding]; other site 997761002805 Walker B motif; other site 997761002806 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 997761002807 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 997761002808 catalytic residues [active] 997761002809 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 997761002810 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 997761002811 GIY-YIG motif/motif A; other site 997761002812 active site 997761002813 catalytic site [active] 997761002814 putative DNA binding site [nucleotide binding]; other site 997761002815 metal binding site [ion binding]; metal-binding site 997761002816 UvrB/uvrC motif; Region: UVR; pfam02151 997761002817 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 997761002818 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 997761002819 DNA binding site [nucleotide binding] 997761002820 CAAX protease self-immunity; Region: Abi; pfam02517 997761002821 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 997761002822 TrkA-N domain; Region: TrkA_N; pfam02254 997761002823 TrkA-C domain; Region: TrkA_C; pfam02080 997761002824 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 997761002825 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 997761002826 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761002827 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761002828 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761002829 dimerization interface [polypeptide binding]; other site 997761002830 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 997761002831 proximal heme binding site [chemical binding]; other site 997761002832 distal heme binding site [chemical binding]; other site 997761002833 putative dimer interface [polypeptide binding]; other site 997761002834 putative Iron-sulfur protein interface [polypeptide binding]; other site 997761002835 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 997761002836 L-aspartate oxidase; Provisional; Region: PRK06175 997761002837 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 997761002838 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 997761002839 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 997761002840 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761002841 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761002842 DNA binding site [nucleotide binding] 997761002843 domain linker motif; other site 997761002844 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 997761002845 ligand binding site [chemical binding]; other site 997761002846 dimerization interface [polypeptide binding]; other site 997761002847 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 997761002848 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 997761002849 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 997761002850 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 997761002851 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 997761002852 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 997761002853 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 997761002854 Histidine kinase; Region: HisKA_3; pfam07730 997761002855 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761002856 ATP binding site [chemical binding]; other site 997761002857 Mg2+ binding site [ion binding]; other site 997761002858 G-X-G motif; other site 997761002859 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761002860 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761002861 active site 997761002862 phosphorylation site [posttranslational modification] 997761002863 intermolecular recognition site; other site 997761002864 dimerization interface [polypeptide binding]; other site 997761002865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761002866 DNA binding residues [nucleotide binding] 997761002867 dimerization interface [polypeptide binding]; other site 997761002868 Erythromycin esterase; Region: Erythro_esteras; pfam05139 997761002869 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 997761002870 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 997761002871 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761002872 dimerization interface [polypeptide binding]; other site 997761002873 Histidine kinase; Region: His_kinase; pfam06580 997761002874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761002875 ATP binding site [chemical binding]; other site 997761002876 Mg2+ binding site [ion binding]; other site 997761002877 G-X-G motif; other site 997761002878 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761002879 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002880 dimer interface [polypeptide binding]; other site 997761002881 conserved gate region; other site 997761002882 ABC-ATPase subunit interface; other site 997761002883 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761002884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002885 dimer interface [polypeptide binding]; other site 997761002886 conserved gate region; other site 997761002887 putative PBP binding loops; other site 997761002888 ABC-ATPase subunit interface; other site 997761002889 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 997761002890 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761002891 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 997761002892 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 997761002893 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761002894 dimerization interface [polypeptide binding]; other site 997761002895 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761002896 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761002897 dimer interface [polypeptide binding]; other site 997761002898 putative CheW interface [polypeptide binding]; other site 997761002899 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761002900 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761002901 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761002902 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 997761002903 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761002904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761002905 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761002906 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002907 dimer interface [polypeptide binding]; other site 997761002908 conserved gate region; other site 997761002909 ABC-ATPase subunit interface; other site 997761002910 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761002911 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002912 dimer interface [polypeptide binding]; other site 997761002913 conserved gate region; other site 997761002914 putative PBP binding loops; other site 997761002915 ABC-ATPase subunit interface; other site 997761002916 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761002917 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 997761002918 Pectate lyase; Region: Pec_lyase_C; cl01593 997761002919 LysE type translocator; Region: LysE; cl00565 997761002920 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 997761002921 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 997761002922 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 997761002923 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 997761002924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761002925 putative substrate translocation pore; other site 997761002926 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761002927 putative DNA binding site [nucleotide binding]; other site 997761002928 dimerization interface [polypeptide binding]; other site 997761002929 putative Zn2+ binding site [ion binding]; other site 997761002930 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 997761002931 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 997761002932 Spo7-like protein; Region: Spo7; pfam03907 997761002933 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 997761002934 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 997761002935 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 997761002936 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 997761002937 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 997761002938 Walker A/P-loop; other site 997761002939 ATP binding site [chemical binding]; other site 997761002940 Q-loop/lid; other site 997761002941 ABC transporter signature motif; other site 997761002942 Walker B; other site 997761002943 D-loop; other site 997761002944 H-loop/switch region; other site 997761002945 TOBE domain; Region: TOBE_2; pfam08402 997761002946 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761002947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002948 dimer interface [polypeptide binding]; other site 997761002949 putative PBP binding loops; other site 997761002950 ABC-ATPase subunit interface; other site 997761002951 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761002952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002953 dimer interface [polypeptide binding]; other site 997761002954 conserved gate region; other site 997761002955 ABC-ATPase subunit interface; other site 997761002956 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761002957 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 997761002958 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 997761002959 Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565 997761002960 active site 997761002961 catalytic site [active] 997761002962 metal binding site [ion binding]; metal-binding site 997761002963 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 997761002964 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 997761002965 Metal-binding active site; metal-binding site 997761002966 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761002967 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761002968 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002969 ABC-ATPase subunit interface; other site 997761002970 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761002971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761002972 dimer interface [polypeptide binding]; other site 997761002973 conserved gate region; other site 997761002974 putative PBP binding loops; other site 997761002975 ABC-ATPase subunit interface; other site 997761002976 Fibronectin-binding protein (FBP); Region: FBP; pfam07299 997761002977 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 997761002978 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761002979 Coenzyme A binding pocket [chemical binding]; other site 997761002980 short chain dehydrogenase; Provisional; Region: PRK12747 997761002981 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 997761002982 NADP binding site [chemical binding]; other site 997761002983 homodimer interface [polypeptide binding]; other site 997761002984 active site 997761002985 substrate binding site [chemical binding]; other site 997761002986 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 997761002987 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761002988 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 997761002989 DoxX-like family; Region: DoxX_2; pfam13564 997761002990 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761002991 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 997761002992 NAD(P) binding site [chemical binding]; other site 997761002993 active site 997761002994 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 997761002995 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 997761002996 DNA binding residues [nucleotide binding] 997761002997 putative dimer interface [polypeptide binding]; other site 997761002998 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 997761002999 DinB superfamily; Region: DinB_2; pfam12867 997761003000 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 997761003001 putative active site [active] 997761003002 Cupin; Region: Cupin_1; smart00835 997761003003 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761003004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761003005 dimer interface [polypeptide binding]; other site 997761003006 conserved gate region; other site 997761003007 putative PBP binding loops; other site 997761003008 ABC-ATPase subunit interface; other site 997761003009 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761003010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761003011 dimer interface [polypeptide binding]; other site 997761003012 conserved gate region; other site 997761003013 putative PBP binding loops; other site 997761003014 ABC-ATPase subunit interface; other site 997761003015 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761003016 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761003017 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 997761003018 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 997761003019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 997761003020 Transposase; Region: DEDD_Tnp_IS110; pfam01548 997761003021 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 997761003022 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761003023 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761003024 active site 997761003025 catalytic tetrad [active] 997761003026 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 997761003027 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761003028 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761003029 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761003030 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 997761003031 HTH-like domain; Region: HTH_21; pfam13276 997761003032 Integrase core domain; Region: rve; pfam00665 997761003033 Integrase core domain; Region: rve_2; pfam13333 997761003034 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761003035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761003036 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 997761003037 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 997761003038 homotrimer interaction site [polypeptide binding]; other site 997761003039 putative active site [active] 997761003040 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761003041 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761003042 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761003043 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761003044 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761003045 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 997761003046 Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718 997761003047 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761003048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761003049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761003050 putative PBP binding loops; other site 997761003051 dimer interface [polypeptide binding]; other site 997761003052 ABC-ATPase subunit interface; other site 997761003053 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761003054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761003055 dimer interface [polypeptide binding]; other site 997761003056 conserved gate region; other site 997761003057 putative PBP binding loops; other site 997761003058 ABC-ATPase subunit interface; other site 997761003059 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761003060 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 997761003061 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 997761003062 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 997761003063 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 997761003064 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 997761003065 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 997761003066 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 997761003067 active site 997761003068 metal binding site [ion binding]; metal-binding site 997761003069 interdomain interaction site; other site 997761003070 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 997761003071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 997761003072 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 997761003073 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 997761003074 DNA binding residues [nucleotide binding] 997761003075 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 997761003076 putative dimer interface [polypeptide binding]; other site 997761003077 short chain dehydrogenase; Provisional; Region: PRK08263 997761003078 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 997761003079 NADP binding site [chemical binding]; other site 997761003080 active site 997761003081 steroid binding site; other site 997761003082 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761003083 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761003084 LysR substrate binding domain; Region: LysR_substrate; pfam03466 997761003085 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 997761003086 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761003087 Phosphotransferase enzyme family; Region: APH; pfam01636 997761003088 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 997761003089 active site 997761003090 substrate binding site [chemical binding]; other site 997761003091 ATP binding site [chemical binding]; other site 997761003092 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761003093 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761003094 active site 997761003095 catalytic tetrad [active] 997761003096 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 997761003097 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 997761003098 DNA binding residues [nucleotide binding] 997761003099 putative dimer interface [polypeptide binding]; other site 997761003100 DinB family; Region: DinB; cl17821 997761003101 DinB superfamily; Region: DinB_2; pfam12867 997761003102 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761003103 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761003104 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 997761003105 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 997761003106 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761003107 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761003108 active site 997761003109 catalytic tetrad [active] 997761003110 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 997761003111 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 997761003112 DNA binding residues [nucleotide binding] 997761003113 putative dimer interface [polypeptide binding]; other site 997761003114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761003115 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761003116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761003117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761003118 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761003119 dimerization interface [polypeptide binding]; other site 997761003120 putative DNA binding site [nucleotide binding]; other site 997761003121 putative Zn2+ binding site [ion binding]; other site 997761003122 arsenical pump membrane protein; Provisional; Region: PRK15445 997761003123 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 997761003124 transmembrane helices; other site 997761003125 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 997761003126 Low molecular weight phosphatase family; Region: LMWPc; cd00115 997761003127 active site 997761003128 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254 997761003129 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761003130 putative metal binding site [ion binding]; other site 997761003131 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 997761003132 active site 997761003133 catalytic residues [active] 997761003134 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 997761003135 FtsX-like permease family; Region: FtsX; pfam02687 997761003136 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 997761003137 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 997761003138 Walker A/P-loop; other site 997761003139 ATP binding site [chemical binding]; other site 997761003140 Q-loop/lid; other site 997761003141 ABC transporter signature motif; other site 997761003142 Walker B; other site 997761003143 D-loop; other site 997761003144 H-loop/switch region; other site 997761003145 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761003146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761003147 dimer interface [polypeptide binding]; other site 997761003148 phosphorylation site [posttranslational modification] 997761003149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761003150 ATP binding site [chemical binding]; other site 997761003151 Mg2+ binding site [ion binding]; other site 997761003152 G-X-G motif; other site 997761003153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761003154 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761003155 active site 997761003156 phosphorylation site [posttranslational modification] 997761003157 intermolecular recognition site; other site 997761003158 dimerization interface [polypeptide binding]; other site 997761003159 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761003160 DNA binding site [nucleotide binding] 997761003161 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761003162 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 997761003163 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761003164 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761003165 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761003166 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761003167 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761003168 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 997761003169 active site 997761003170 metal binding site [ion binding]; metal-binding site 997761003171 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 997761003172 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 997761003173 DNA binding residues [nucleotide binding] 997761003174 drug binding residues [chemical binding]; other site 997761003175 dimer interface [polypeptide binding]; other site 997761003176 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 997761003177 short chain dehydrogenase; Provisional; Region: PRK12747 997761003178 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 997761003179 NADP binding site [chemical binding]; other site 997761003180 homodimer interface [polypeptide binding]; other site 997761003181 active site 997761003182 substrate binding site [chemical binding]; other site 997761003183 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 997761003184 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 997761003185 putative substrate binding site [chemical binding]; other site 997761003186 putative ATP binding site [chemical binding]; other site 997761003187 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 997761003188 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 997761003189 active site 997761003190 P-loop; other site 997761003191 phosphorylation site [posttranslational modification] 997761003192 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 997761003193 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 997761003194 active site 997761003195 phosphorylation site [posttranslational modification] 997761003196 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 997761003197 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 997761003198 active site 997761003199 catalytic triad [active] 997761003200 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 997761003201 Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136 997761003202 NAD(P) binding site [chemical binding]; other site 997761003203 catalytic residues [active] 997761003204 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 997761003205 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 997761003206 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 997761003207 ligand binding site [chemical binding]; other site 997761003208 Response regulator receiver domain; Region: Response_reg; pfam00072 997761003209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761003210 active site 997761003211 phosphorylation site [posttranslational modification] 997761003212 intermolecular recognition site; other site 997761003213 dimerization interface [polypeptide binding]; other site 997761003214 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761003215 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761003216 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761003217 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761003218 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761003219 dimerization interface [polypeptide binding]; other site 997761003220 Histidine kinase; Region: His_kinase; pfam06580 997761003221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761003222 ATP binding site [chemical binding]; other site 997761003223 Mg2+ binding site [ion binding]; other site 997761003224 G-X-G motif; other site 997761003225 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 997761003226 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 997761003227 putative ligand binding site [chemical binding]; other site 997761003228 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 997761003229 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 997761003230 Walker A/P-loop; other site 997761003231 ATP binding site [chemical binding]; other site 997761003232 Q-loop/lid; other site 997761003233 ABC transporter signature motif; other site 997761003234 Walker B; other site 997761003235 D-loop; other site 997761003236 H-loop/switch region; other site 997761003237 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 997761003238 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761003239 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 997761003240 TM-ABC transporter signature motif; other site 997761003241 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761003242 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 997761003243 TM-ABC transporter signature motif; other site 997761003244 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 997761003245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761003246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761003247 Domain of unknown function (DUF1961); Region: DUF1961; pfam09224 997761003248 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761003249 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761003250 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761003251 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761003252 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761003253 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761003254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761003255 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 997761003256 putative active site [active] 997761003257 putative metal binding site [ion binding]; other site 997761003258 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 997761003259 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865 997761003260 putative hydrophobic ligand binding site [chemical binding]; other site 997761003261 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar1; cd08583 997761003262 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 997761003263 putative active site [active] 997761003264 catalytic site [active] 997761003265 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 997761003266 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 997761003267 active site 997761003268 metal binding site [ion binding]; metal-binding site 997761003269 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 997761003270 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 997761003271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761003272 dimer interface [polypeptide binding]; other site 997761003273 conserved gate region; other site 997761003274 ABC-ATPase subunit interface; other site 997761003275 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 997761003276 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 997761003277 Walker A/P-loop; other site 997761003278 ATP binding site [chemical binding]; other site 997761003279 Q-loop/lid; other site 997761003280 ABC transporter signature motif; other site 997761003281 Walker B; other site 997761003282 D-loop; other site 997761003283 H-loop/switch region; other site 997761003284 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 997761003285 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 997761003286 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 997761003287 substrate binding site [chemical binding]; other site 997761003288 dimer interface [polypeptide binding]; other site 997761003289 ATP binding site [chemical binding]; other site 997761003290 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 997761003291 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761003292 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761003293 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 997761003294 Cytochrome P450; Region: p450; pfam00067 997761003295 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 997761003296 Flavodoxin; Region: Flavodoxin_1; pfam00258 997761003297 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 997761003298 FAD binding pocket [chemical binding]; other site 997761003299 FAD binding motif [chemical binding]; other site 997761003300 catalytic residues [active] 997761003301 NAD binding pocket [chemical binding]; other site 997761003302 phosphate binding motif [ion binding]; other site 997761003303 beta-alpha-beta structure motif; other site 997761003304 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761003305 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761003306 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761003307 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761003308 active site 997761003309 catalytic tetrad [active] 997761003310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761003311 putative substrate translocation pore; other site 997761003312 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761003313 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 997761003314 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 997761003315 Catalytic site [active] 997761003316 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 997761003317 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761003318 non-specific DNA binding site [nucleotide binding]; other site 997761003319 salt bridge; other site 997761003320 sequence-specific DNA binding site [nucleotide binding]; other site 997761003321 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 997761003322 SpoVR like protein; Region: SpoVR; pfam04293 997761003323 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 997761003324 asparagine synthetase AsnA; Provisional; Region: PRK05425 997761003325 motif 1; other site 997761003326 dimer interface [polypeptide binding]; other site 997761003327 active site 997761003328 motif 2; other site 997761003329 motif 3; other site 997761003330 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 997761003331 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761003332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761003333 dimer interface [polypeptide binding]; other site 997761003334 phosphorylation site [posttranslational modification] 997761003335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761003336 ATP binding site [chemical binding]; other site 997761003337 Mg2+ binding site [ion binding]; other site 997761003338 G-X-G motif; other site 997761003339 Response regulator receiver domain; Region: Response_reg; pfam00072 997761003340 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761003341 active site 997761003342 phosphorylation site [posttranslational modification] 997761003343 intermolecular recognition site; other site 997761003344 dimerization interface [polypeptide binding]; other site 997761003345 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761003346 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761003347 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761003348 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761003349 dimerization interface [polypeptide binding]; other site 997761003350 Histidine kinase; Region: His_kinase; pfam06580 997761003351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761003352 ATP binding site [chemical binding]; other site 997761003353 Mg2+ binding site [ion binding]; other site 997761003354 G-X-G motif; other site 997761003355 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761003356 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761003357 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761003358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761003359 dimer interface [polypeptide binding]; other site 997761003360 conserved gate region; other site 997761003361 ABC-ATPase subunit interface; other site 997761003362 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761003363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761003364 dimer interface [polypeptide binding]; other site 997761003365 conserved gate region; other site 997761003366 ABC-ATPase subunit interface; other site 997761003367 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 997761003368 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 997761003369 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 997761003370 active site 997761003371 catalytic residues [active] 997761003372 ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067 997761003373 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 997761003374 Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985 997761003375 ethanolamine permease; Region: 2A0305; TIGR00908 997761003376 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761003377 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 997761003378 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 997761003379 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 997761003380 active site 997761003381 putative pectinesterase; Region: PLN02432; cl01911 997761003382 Pectinesterase; Region: Pectinesterase; pfam01095 997761003383 threonine synthase; Validated; Region: PRK08197 997761003384 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 997761003385 homodimer interface [polypeptide binding]; other site 997761003386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761003387 catalytic residue [active] 997761003388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761003389 dimer interface [polypeptide binding]; other site 997761003390 conserved gate region; other site 997761003391 putative PBP binding loops; other site 997761003392 ABC-ATPase subunit interface; other site 997761003393 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 997761003394 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761003395 dimer interface [polypeptide binding]; other site 997761003396 conserved gate region; other site 997761003397 putative PBP binding loops; other site 997761003398 ABC-ATPase subunit interface; other site 997761003399 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 997761003400 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 997761003401 Walker A/P-loop; other site 997761003402 ATP binding site [chemical binding]; other site 997761003403 Q-loop/lid; other site 997761003404 ABC transporter signature motif; other site 997761003405 Walker B; other site 997761003406 D-loop; other site 997761003407 H-loop/switch region; other site 997761003408 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 997761003409 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761003410 substrate binding pocket [chemical binding]; other site 997761003411 membrane-bound complex binding site; other site 997761003412 hinge residues; other site 997761003413 FAD binding site [chemical binding]; other site 997761003414 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 997761003415 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761003416 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761003417 dimer interface [polypeptide binding]; other site 997761003418 phosphorylation site [posttranslational modification] 997761003419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761003420 ATP binding site [chemical binding]; other site 997761003421 Mg2+ binding site [ion binding]; other site 997761003422 G-X-G motif; other site 997761003423 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 997761003424 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 997761003425 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 997761003426 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 997761003427 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 997761003428 Transcriptional regulators [Transcription]; Region: FadR; COG2186 997761003429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761003430 DNA-binding site [nucleotide binding]; DNA binding site 997761003431 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 997761003432 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 997761003433 nudix motif; other site 997761003434 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 997761003435 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 997761003436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761003437 Coenzyme A binding pocket [chemical binding]; other site 997761003438 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 997761003439 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 997761003440 active site 997761003441 putative substrate binding pocket [chemical binding]; other site 997761003442 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 997761003443 Protein of unknown function DUF58; Region: DUF58; pfam01882 997761003444 MoxR-like ATPases [General function prediction only]; Region: COG0714 997761003445 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761003446 Walker A motif; other site 997761003447 ATP binding site [chemical binding]; other site 997761003448 Walker B motif; other site 997761003449 arginine finger; other site 997761003450 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 997761003451 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 997761003452 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 997761003453 active site 997761003454 Zn binding site [ion binding]; other site 997761003455 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 997761003456 Transcriptional regulator [Transcription]; Region: IclR; COG1414 997761003457 Bacterial transcriptional regulator; Region: IclR; pfam01614 997761003458 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 997761003459 classical (c) SDRs; Region: SDR_c; cd05233 997761003460 NAD(P) binding site [chemical binding]; other site 997761003461 active site 997761003462 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 997761003463 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 997761003464 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 997761003465 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 997761003466 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 997761003467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761003468 NAD(P) binding site [chemical binding]; other site 997761003469 active site 997761003470 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 997761003471 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 997761003472 active site 997761003473 dimer interface [polypeptide binding]; other site 997761003474 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 997761003475 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 997761003476 active site 997761003477 trimer interface [polypeptide binding]; other site 997761003478 allosteric site; other site 997761003479 active site lid [active] 997761003480 hexamer (dimer of trimers) interface [polypeptide binding]; other site 997761003481 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 997761003482 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 997761003483 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 997761003484 Domain of unknown function (DUF1802); Region: DUF1802; pfam08819 997761003485 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 997761003486 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 997761003487 Walker A/P-loop; other site 997761003488 ATP binding site [chemical binding]; other site 997761003489 Q-loop/lid; other site 997761003490 ABC transporter signature motif; other site 997761003491 Walker B; other site 997761003492 D-loop; other site 997761003493 H-loop/switch region; other site 997761003494 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 997761003495 FeS assembly protein SufD; Region: sufD; TIGR01981 997761003496 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 997761003497 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 997761003498 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 997761003499 catalytic residue [active] 997761003500 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 997761003501 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 997761003502 trimerization site [polypeptide binding]; other site 997761003503 active site 997761003504 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 997761003505 FeS assembly protein SufB; Region: sufB; TIGR01980 997761003506 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761003507 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 997761003508 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 997761003509 NADH(P)-binding; Region: NAD_binding_10; pfam13460 997761003510 NAD binding site [chemical binding]; other site 997761003511 substrate binding site [chemical binding]; other site 997761003512 putative active site [active] 997761003513 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 997761003514 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 997761003515 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 997761003516 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 997761003517 DNA binding residues [nucleotide binding] 997761003518 HAMP domain; Region: HAMP; pfam00672 997761003519 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761003520 dimer interface [polypeptide binding]; other site 997761003521 phosphorylation site [posttranslational modification] 997761003522 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761003523 ATP binding site [chemical binding]; other site 997761003524 Mg2+ binding site [ion binding]; other site 997761003525 G-X-G motif; other site 997761003526 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761003527 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761003528 active site 997761003529 phosphorylation site [posttranslational modification] 997761003530 intermolecular recognition site; other site 997761003531 dimerization interface [polypeptide binding]; other site 997761003532 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761003533 DNA binding site [nucleotide binding] 997761003534 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 997761003535 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 997761003536 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 997761003537 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761003538 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761003539 dimerization interface [polypeptide binding]; other site 997761003540 putative Zn2+ binding site [ion binding]; other site 997761003541 putative DNA binding site [nucleotide binding]; other site 997761003542 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761003543 NADH(P)-binding; Region: NAD_binding_10; pfam13460 997761003544 NAD(P) binding site [chemical binding]; other site 997761003545 active site 997761003546 Predicted integral membrane protein (DUF2269); Region: DUF2269; cl02335 997761003547 short chain dehydrogenase; Provisional; Region: PRK06172 997761003548 classical (c) SDRs; Region: SDR_c; cd05233 997761003549 NAD(P) binding site [chemical binding]; other site 997761003550 active site 997761003551 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761003552 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761003553 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761003554 NAD(P) binding site [chemical binding]; other site 997761003555 active site 997761003556 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 997761003557 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 997761003558 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761003559 putative substrate translocation pore; other site 997761003560 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 997761003561 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 997761003562 Uncharacterized conserved protein [Function unknown]; Region: COG1284 997761003563 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 997761003564 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 997761003565 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 997761003566 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 997761003567 putative hydrophobic ligand binding site [chemical binding]; other site 997761003568 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761003569 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761003570 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761003571 dimerization interface [polypeptide binding]; other site 997761003572 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 997761003573 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 997761003574 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761003575 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 997761003576 NlpC/P60 family; Region: NLPC_P60; pfam00877 997761003577 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 997761003578 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 997761003579 Zn2+ binding site [ion binding]; other site 997761003580 Mg2+ binding site [ion binding]; other site 997761003581 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 997761003582 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 997761003583 ATP binding site [chemical binding]; other site 997761003584 substrate interface [chemical binding]; other site 997761003585 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 997761003586 MoaE interaction surface [polypeptide binding]; other site 997761003587 MoeB interaction surface [polypeptide binding]; other site 997761003588 thiocarboxylated glycine; other site 997761003589 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 997761003590 MoaE homodimer interface [polypeptide binding]; other site 997761003591 MoaD interaction [polypeptide binding]; other site 997761003592 active site residues [active] 997761003593 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 997761003594 Moco binding site; other site 997761003595 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 997761003596 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 997761003597 active site 997761003598 metal binding site [ion binding]; metal-binding site 997761003599 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 997761003600 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 997761003601 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761003602 FeS/SAM binding site; other site 997761003603 YfkB-like domain; Region: YfkB; pfam08756 997761003604 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 997761003605 Domain of unknown function DUF21; Region: DUF21; pfam01595 997761003606 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 997761003607 Transporter associated domain; Region: CorC_HlyC; smart01091 997761003608 Domain of unknown function DUF20; Region: UPF0118; pfam01594 997761003609 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 997761003610 Uncharacterized conserved protein [Function unknown]; Region: COG1284 997761003611 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 997761003612 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 997761003613 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 997761003614 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 997761003615 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 997761003616 NlpC/P60 family; Region: NLPC_P60; pfam00877 997761003617 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 997761003618 CotJB protein; Region: CotJB; pfam12652 997761003619 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 997761003620 dinuclear metal binding motif [ion binding]; other site 997761003621 SEFIR domain; Region: SEFIR; pfam08357 997761003622 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 997761003623 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761003624 non-specific DNA binding site [nucleotide binding]; other site 997761003625 salt bridge; other site 997761003626 sequence-specific DNA binding site [nucleotide binding]; other site 997761003627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761003628 non-specific DNA binding site [nucleotide binding]; other site 997761003629 salt bridge; other site 997761003630 sequence-specific DNA binding site [nucleotide binding]; other site 997761003631 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761003632 non-specific DNA binding site [nucleotide binding]; other site 997761003633 salt bridge; other site 997761003634 sequence-specific DNA binding site [nucleotide binding]; other site 997761003635 Protein of unknown function (DUF2538); Region: DUF2538; pfam10804 997761003636 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 997761003637 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 997761003638 active site 997761003639 DNA binding site [nucleotide binding] 997761003640 Int/Topo IB signature motif; other site 997761003641 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 997761003642 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 997761003643 ATP binding site [chemical binding]; other site 997761003644 putative Mg++ binding site [ion binding]; other site 997761003645 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 997761003646 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 997761003647 active site 997761003648 IncA protein; Region: IncA; pfam04156 997761003649 YebO-like protein; Region: YebO; pfam13974 997761003650 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 997761003651 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 997761003652 Phage-related protein [Function unknown]; Region: COG4695 997761003653 Phage portal protein; Region: Phage_portal; pfam04860 997761003654 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 997761003655 Dyggve-Melchior-Clausen syndrome protein; Region: Dymeclin; cl15483 997761003656 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 997761003657 Phage capsid family; Region: Phage_capsid; pfam05065 997761003658 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 997761003659 oligomerization interface [polypeptide binding]; other site 997761003660 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 997761003661 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 997761003662 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 997761003663 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 997761003664 active site 997761003665 catalytic triad [active] 997761003666 oxyanion hole [active] 997761003667 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761003668 Interdomain contacts; other site 997761003669 Cytokine receptor motif; other site 997761003670 Phage tail protein; Region: Sipho_tail; cl17486 997761003671 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 997761003672 amidase catalytic site [active] 997761003673 Zn binding residues [ion binding]; other site 997761003674 substrate binding site [chemical binding]; other site 997761003675 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 997761003676 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 997761003677 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 997761003678 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 997761003679 IHF dimer interface [polypeptide binding]; other site 997761003680 IHF - DNA interface [nucleotide binding]; other site 997761003681 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 997761003682 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 997761003683 active site 997761003684 DNA binding site [nucleotide binding] 997761003685 Int/Topo IB signature motif; other site 997761003686 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 997761003687 binding surface 997761003688 TPR motif; other site 997761003689 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761003690 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761003691 hypothetical protein; Provisional; Region: PRK09739 997761003692 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 997761003693 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 997761003694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761003695 DNA-binding site [nucleotide binding]; DNA binding site 997761003696 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761003697 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761003698 homodimer interface [polypeptide binding]; other site 997761003699 catalytic residue [active] 997761003700 DinB superfamily; Region: DinB_2; pfam12867 997761003701 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 997761003702 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 997761003703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 997761003704 Transposase; Region: DEDD_Tnp_IS110; pfam01548 997761003705 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 997761003706 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761003707 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761003708 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 997761003709 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 997761003710 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 997761003711 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 997761003712 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 997761003713 Protein of unknown function (DUF975); Region: DUF975; cl10504 997761003714 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 997761003715 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 997761003716 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 997761003717 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 997761003718 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761003719 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 997761003720 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761003721 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761003722 putative substrate translocation pore; other site 997761003723 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761003724 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761003725 MarR family; Region: MarR_2; pfam12802 997761003726 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 997761003727 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 997761003728 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 997761003729 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 997761003730 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 997761003731 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 997761003732 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761003733 DNA-binding site [nucleotide binding]; DNA binding site 997761003734 DRTGG domain; Region: DRTGG; pfam07085 997761003735 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 997761003736 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 997761003737 active site 2 [active] 997761003738 active site 1 [active] 997761003739 YtpI-like protein; Region: YtpI; pfam14007 997761003740 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 997761003741 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 997761003742 tetramer interfaces [polypeptide binding]; other site 997761003743 binuclear metal-binding site [ion binding]; other site 997761003744 Flavodoxin domain; Region: Flavodoxin_5; cl17428 997761003745 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 997761003746 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 997761003747 pyruvate kinase; Provisional; Region: PRK06354 997761003748 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 997761003749 domain interfaces; other site 997761003750 active site 997761003751 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 997761003752 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 997761003753 active site 997761003754 polyphosphate kinase; Provisional; Region: PRK05443 997761003755 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 997761003756 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 997761003757 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 997761003758 putative domain interface [polypeptide binding]; other site 997761003759 putative active site [active] 997761003760 catalytic site [active] 997761003761 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 997761003762 putative domain interface [polypeptide binding]; other site 997761003763 putative active site [active] 997761003764 catalytic site [active] 997761003765 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 997761003766 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 997761003767 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 997761003768 dimer interface [polypeptide binding]; other site 997761003769 Citrate synthase; Region: Citrate_synt; pfam00285 997761003770 active site 997761003771 citrylCoA binding site [chemical binding]; other site 997761003772 oxalacetate/citrate binding site [chemical binding]; other site 997761003773 coenzyme A binding site [chemical binding]; other site 997761003774 catalytic triad [active] 997761003775 isocitrate dehydrogenase; Validated; Region: PRK06451 997761003776 isocitrate dehydrogenase; Reviewed; Region: PRK07006 997761003777 malate dehydrogenase; Reviewed; Region: PRK06223 997761003778 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 997761003779 NAD(P) binding site [chemical binding]; other site 997761003780 dimer interface [polypeptide binding]; other site 997761003781 tetramer (dimer of dimers) interface [polypeptide binding]; other site 997761003782 substrate binding site [chemical binding]; other site 997761003783 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 997761003784 5'-nucleotidase; Provisional; Region: PRK03826 997761003785 Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681 997761003786 Fumarase C-terminus; Region: Fumerase_C; pfam05683 997761003787 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 997761003788 Sodium Bile acid symporter family; Region: SBF; cl17470 997761003789 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 997761003790 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 997761003791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761003792 dimerization interface [polypeptide binding]; other site 997761003793 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761003794 putative active site [active] 997761003795 heme pocket [chemical binding]; other site 997761003796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761003797 dimer interface [polypeptide binding]; other site 997761003798 phosphorylation site [posttranslational modification] 997761003799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761003800 ATP binding site [chemical binding]; other site 997761003801 Mg2+ binding site [ion binding]; other site 997761003802 G-X-G motif; other site 997761003803 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761003804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761003805 active site 997761003806 phosphorylation site [posttranslational modification] 997761003807 intermolecular recognition site; other site 997761003808 dimerization interface [polypeptide binding]; other site 997761003809 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761003810 DNA binding site [nucleotide binding] 997761003811 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761003812 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761003813 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761003814 CHASE3 domain; Region: CHASE3; cl05000 997761003815 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761003816 dimerization interface [polypeptide binding]; other site 997761003817 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761003818 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761003819 dimer interface [polypeptide binding]; other site 997761003820 putative CheW interface [polypeptide binding]; other site 997761003821 PBP superfamily domain; Region: PBP_like_2; cl17296 997761003822 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 997761003823 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 997761003824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761003825 dimer interface [polypeptide binding]; other site 997761003826 conserved gate region; other site 997761003827 putative PBP binding loops; other site 997761003828 ABC-ATPase subunit interface; other site 997761003829 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 997761003830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761003831 dimer interface [polypeptide binding]; other site 997761003832 conserved gate region; other site 997761003833 putative PBP binding loops; other site 997761003834 ABC-ATPase subunit interface; other site 997761003835 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 997761003836 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 997761003837 Walker A/P-loop; other site 997761003838 ATP binding site [chemical binding]; other site 997761003839 Q-loop/lid; other site 997761003840 ABC transporter signature motif; other site 997761003841 Walker B; other site 997761003842 D-loop; other site 997761003843 H-loop/switch region; other site 997761003844 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 997761003845 PhoU domain; Region: PhoU; pfam01895 997761003846 PhoU domain; Region: PhoU; pfam01895 997761003847 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 997761003848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761003849 motif II; other site 997761003850 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 997761003851 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 997761003852 DNA binding site [nucleotide binding] 997761003853 catalytic residue [active] 997761003854 H2TH interface [polypeptide binding]; other site 997761003855 putative catalytic residues [active] 997761003856 turnover-facilitating residue; other site 997761003857 intercalation triad [nucleotide binding]; other site 997761003858 8OG recognition residue [nucleotide binding]; other site 997761003859 putative reading head residues; other site 997761003860 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 997761003861 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 997761003862 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 997761003863 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 997761003864 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 997761003865 CoA-binding site [chemical binding]; other site 997761003866 ATP-binding [chemical binding]; other site 997761003867 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 997761003868 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 997761003869 N-acetyl-D-glucosamine binding site [chemical binding]; other site 997761003870 catalytic residue [active] 997761003871 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 997761003872 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 997761003873 ATP cone domain; Region: ATP-cone; pfam03477 997761003874 SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366 997761003875 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 997761003876 Predicted flavoprotein [General function prediction only]; Region: COG0431 997761003877 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 997761003878 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761003879 dimerization interface [polypeptide binding]; other site 997761003880 putative DNA binding site [nucleotide binding]; other site 997761003881 Winged helix-turn helix; Region: HTH_29; pfam13551 997761003882 putative Zn2+ binding site [ion binding]; other site 997761003883 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 997761003884 putative hydrophobic ligand binding site [chemical binding]; other site 997761003885 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761003886 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 997761003887 Domain of unknown function (DUF4180); Region: DUF4180; pfam13788 997761003888 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761003889 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251 997761003890 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 997761003891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 997761003892 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 997761003893 TPR motif; other site 997761003894 binding surface 997761003895 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761003896 DNA binding residues [nucleotide binding] 997761003897 dimerization interface [polypeptide binding]; other site 997761003898 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 997761003899 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 997761003900 putative NAD(P) binding site [chemical binding]; other site 997761003901 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761003902 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761003903 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 997761003904 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761003905 Coenzyme A binding pocket [chemical binding]; other site 997761003906 Response regulator receiver domain; Region: Response_reg; pfam00072 997761003907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761003908 active site 997761003909 phosphorylation site [posttranslational modification] 997761003910 intermolecular recognition site; other site 997761003911 dimerization interface [polypeptide binding]; other site 997761003912 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761003913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761003914 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761003915 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761003916 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761003917 dimerization interface [polypeptide binding]; other site 997761003918 Histidine kinase; Region: His_kinase; pfam06580 997761003919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761003920 ATP binding site [chemical binding]; other site 997761003921 Mg2+ binding site [ion binding]; other site 997761003922 G-X-G motif; other site 997761003923 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761003924 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761003925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761003926 dimer interface [polypeptide binding]; other site 997761003927 conserved gate region; other site 997761003928 putative PBP binding loops; other site 997761003929 ABC-ATPase subunit interface; other site 997761003930 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761003931 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 997761003932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761003933 dimer interface [polypeptide binding]; other site 997761003934 conserved gate region; other site 997761003935 putative PBP binding loops; other site 997761003936 ABC-ATPase subunit interface; other site 997761003937 pyruvate phosphate dikinase; Provisional; Region: PRK09279 997761003938 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 997761003939 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 997761003940 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 997761003941 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 997761003942 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 997761003943 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 997761003944 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 997761003945 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 997761003946 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 997761003947 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 997761003948 Fungal chitosanase of glycosyl hydrolase group 75; Region: Glyco_hydro_75; pfam07335 997761003949 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 997761003950 active site residue [active] 997761003951 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 997761003952 putative homodimer interface [polypeptide binding]; other site 997761003953 putative homotetramer interface [polypeptide binding]; other site 997761003954 putative metal binding site [ion binding]; other site 997761003955 putative homodimer-homodimer interface [polypeptide binding]; other site 997761003956 putative allosteric switch controlling residues; other site 997761003957 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 997761003958 active site residue [active] 997761003959 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 997761003960 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 997761003961 CPxP motif; other site 997761003962 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 997761003963 active site residue [active] 997761003964 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 997761003965 active site residue [active] 997761003966 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 997761003967 Acyltransferase family; Region: Acyl_transf_3; pfam01757 997761003968 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761003969 Interdomain contacts; other site 997761003970 Cytokine receptor motif; other site 997761003971 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761003972 Interdomain contacts; other site 997761003973 Cytokine receptor motif; other site 997761003974 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 997761003975 dockerin binding interface; other site 997761003976 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 997761003977 Cation efflux family; Region: Cation_efflux; pfam01545 997761003978 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 997761003979 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 997761003980 nudix motif; other site 997761003981 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761003982 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761003983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761003984 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761003985 putative substrate translocation pore; other site 997761003986 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 997761003987 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 997761003988 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 997761003989 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 997761003990 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 997761003991 Transposase; Region: DEDD_Tnp_IS110; pfam01548 997761003992 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 997761003993 Epoxide hydrolase N terminus; Region: EHN; pfam06441 997761003994 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 997761003995 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 997761003996 Predicted transcriptional regulator [Transcription]; Region: COG2378 997761003997 HTH domain; Region: HTH_11; pfam08279 997761003998 WYL domain; Region: WYL; pfam13280 997761003999 short chain dehydrogenase; Provisional; Region: PRK12939 997761004000 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 997761004001 NADP binding site [chemical binding]; other site 997761004002 homodimer interface [polypeptide binding]; other site 997761004003 active site 997761004004 substrate binding site [chemical binding]; other site 997761004005 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353 997761004006 putative dimer interface [polypeptide binding]; other site 997761004007 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761004008 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 997761004009 active site 1 [active] 997761004010 dimer interface [polypeptide binding]; other site 997761004011 hexamer interface [polypeptide binding]; other site 997761004012 active site 2 [active] 997761004013 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761004014 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761004015 putative DNA binding site [nucleotide binding]; other site 997761004016 dimerization interface [polypeptide binding]; other site 997761004017 putative Zn2+ binding site [ion binding]; other site 997761004018 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 997761004019 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 997761004020 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761004021 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761004022 short chain dehydrogenase; Validated; Region: PRK08264 997761004023 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761004024 NAD(P) binding site [chemical binding]; other site 997761004025 active site 997761004026 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 997761004027 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761004028 NAD(P) binding site [chemical binding]; other site 997761004029 active site 997761004030 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 997761004031 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 997761004032 putative NAD(P) binding site [chemical binding]; other site 997761004033 Methyltransferase domain; Region: Methyltransf_31; pfam13847 997761004034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761004035 S-adenosylmethionine binding site [chemical binding]; other site 997761004036 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761004037 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 997761004038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 997761004039 Histidine kinase; Region: HisKA_3; pfam07730 997761004040 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 997761004041 ATP binding site [chemical binding]; other site 997761004042 Mg2+ binding site [ion binding]; other site 997761004043 G-X-G motif; other site 997761004044 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761004045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761004046 active site 997761004047 phosphorylation site [posttranslational modification] 997761004048 intermolecular recognition site; other site 997761004049 dimerization interface [polypeptide binding]; other site 997761004050 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761004051 DNA binding residues [nucleotide binding] 997761004052 dimerization interface [polypeptide binding]; other site 997761004053 DoxX-like family; Region: DoxX_2; pfam13564 997761004054 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 997761004055 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 997761004056 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761004057 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761004058 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004059 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 997761004060 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 997761004061 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 997761004062 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 997761004063 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 997761004064 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 997761004065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761004066 putative substrate translocation pore; other site 997761004067 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 997761004068 regulatory protein interface [polypeptide binding]; other site 997761004069 active site 997761004070 regulatory phosphorylation site [posttranslational modification]; other site 997761004071 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 997761004072 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 997761004073 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 997761004074 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761004075 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004076 ABC-ATPase subunit interface; other site 997761004077 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761004078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004079 dimer interface [polypeptide binding]; other site 997761004080 conserved gate region; other site 997761004081 putative PBP binding loops; other site 997761004082 ABC-ATPase subunit interface; other site 997761004083 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761004084 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004085 Outer membrane lipoprotein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: LolB; COG3017 997761004086 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761004087 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 997761004088 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 997761004089 Cache domain; Region: Cache_1; pfam02743 997761004090 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761004091 Histidine kinase; Region: His_kinase; pfam06580 997761004092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761004093 ATP binding site [chemical binding]; other site 997761004094 Mg2+ binding site [ion binding]; other site 997761004095 G-X-G motif; other site 997761004096 Response regulator receiver domain; Region: Response_reg; pfam00072 997761004097 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761004098 active site 997761004099 phosphorylation site [posttranslational modification] 997761004100 intermolecular recognition site; other site 997761004101 dimerization interface [polypeptide binding]; other site 997761004102 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761004103 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004104 Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956 997761004105 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 997761004106 NodB motif; other site 997761004107 putative active site [active] 997761004108 putative catalytic site [active] 997761004109 putative Zn binding site [ion binding]; other site 997761004110 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761004111 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761004112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004113 dimer interface [polypeptide binding]; other site 997761004114 conserved gate region; other site 997761004115 putative PBP binding loops; other site 997761004116 ABC-ATPase subunit interface; other site 997761004117 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761004118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004119 dimer interface [polypeptide binding]; other site 997761004120 conserved gate region; other site 997761004121 putative PBP binding loops; other site 997761004122 ABC-ATPase subunit interface; other site 997761004123 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 997761004124 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 997761004125 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 997761004126 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 997761004127 heme-binding site [chemical binding]; other site 997761004128 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 997761004129 FAD binding pocket [chemical binding]; other site 997761004130 FAD binding motif [chemical binding]; other site 997761004131 phosphate binding motif [ion binding]; other site 997761004132 beta-alpha-beta structure motif; other site 997761004133 NAD binding pocket [chemical binding]; other site 997761004134 Heme binding pocket [chemical binding]; other site 997761004135 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 997761004136 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 997761004137 ligand binding site [chemical binding]; other site 997761004138 flexible hinge region; other site 997761004139 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 997761004140 non-specific DNA interactions [nucleotide binding]; other site 997761004141 DNA binding site [nucleotide binding] 997761004142 sequence specific DNA binding site [nucleotide binding]; other site 997761004143 putative cAMP binding site [chemical binding]; other site 997761004144 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 997761004145 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 997761004146 Pyruvate formate lyase 1; Region: PFL1; cd01678 997761004147 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 997761004148 coenzyme A binding site [chemical binding]; other site 997761004149 active site 997761004150 catalytic residues [active] 997761004151 glycine loop; other site 997761004152 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 997761004153 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761004154 FeS/SAM binding site; other site 997761004155 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 997761004156 Protein of unknown function (DUF3147); Region: DUF3147; pfam11345 997761004157 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959 997761004158 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 997761004159 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 997761004160 [4Fe-4S] binding site [ion binding]; other site 997761004161 molybdopterin cofactor binding site; other site 997761004162 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 997761004163 molybdopterin cofactor binding site; other site 997761004164 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 997761004165 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 997761004166 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 997761004167 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 997761004168 iron-sulfur cluster [ion binding]; other site 997761004169 [2Fe-2S] cluster binding site [ion binding]; other site 997761004170 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 997761004171 putative hydrophobic ligand binding site [chemical binding]; other site 997761004172 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 997761004173 putative hydrophobic ligand binding site [chemical binding]; other site 997761004174 hydroxylamine reductase; Provisional; Region: PRK12310 997761004175 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 997761004176 ACS interaction site; other site 997761004177 CODH interaction site; other site 997761004178 metal cluster binding site [ion binding]; other site 997761004179 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 997761004180 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 997761004181 ligand binding site [chemical binding]; other site 997761004182 flexible hinge region; other site 997761004183 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 997761004184 non-specific DNA interactions [nucleotide binding]; other site 997761004185 DNA binding site [nucleotide binding] 997761004186 sequence specific DNA binding site [nucleotide binding]; other site 997761004187 putative cAMP binding site [chemical binding]; other site 997761004188 GAF domain; Region: GAF; pfam01590 997761004189 GAF domain; Region: GAF_2; pfam13185 997761004190 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761004191 PAS domain; Region: PAS_9; pfam13426 997761004192 putative active site [active] 997761004193 heme pocket [chemical binding]; other site 997761004194 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 997761004195 Histidine kinase; Region: HisKA_3; pfam07730 997761004196 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761004197 ATP binding site [chemical binding]; other site 997761004198 Mg2+ binding site [ion binding]; other site 997761004199 G-X-G motif; other site 997761004200 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 997761004201 30S subunit binding site; other site 997761004202 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 997761004203 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 997761004204 putative catalytic cysteine [active] 997761004205 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 997761004206 putative active site [active] 997761004207 metal binding site [ion binding]; metal-binding site 997761004208 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 997761004209 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 997761004210 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 997761004211 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 997761004212 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 997761004213 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 997761004214 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 997761004215 iron-sulfur cluster [ion binding]; other site 997761004216 [2Fe-2S] cluster binding site [ion binding]; other site 997761004217 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 997761004218 GTP binding site; other site 997761004219 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 997761004220 dimerization interface [polypeptide binding]; other site 997761004221 active site 997761004222 PAS fold; Region: PAS_4; pfam08448 997761004223 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 997761004224 putative active site [active] 997761004225 heme pocket [chemical binding]; other site 997761004226 PAS domain S-box; Region: sensory_box; TIGR00229 997761004227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761004228 putative active site [active] 997761004229 heme pocket [chemical binding]; other site 997761004230 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761004231 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761004232 metal binding site [ion binding]; metal-binding site 997761004233 active site 997761004234 I-site; other site 997761004235 NlpC/P60 family; Region: NLPC_P60; pfam00877 997761004236 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 997761004237 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 997761004238 active sites [active] 997761004239 tetramer interface [polypeptide binding]; other site 997761004240 imidazolonepropionase; Validated; Region: PRK09356 997761004241 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 997761004242 active site 997761004243 allantoate amidohydrolase; Reviewed; Region: PRK09290 997761004244 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 997761004245 active site 997761004246 metal binding site [ion binding]; metal-binding site 997761004247 dimer interface [polypeptide binding]; other site 997761004248 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 997761004249 N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228 997761004250 active site 997761004251 putative substrate binding pocket [chemical binding]; other site 997761004252 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; pfam01373 997761004253 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 997761004254 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 997761004255 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 997761004256 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 997761004257 active site 997761004258 catalytic site [active] 997761004259 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 997761004260 EamA-like transporter family; Region: EamA; pfam00892 997761004261 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; pfam01373 997761004262 The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347 997761004263 starch-binding site 2 [chemical binding]; other site 997761004264 starch-binding site 1 [chemical binding]; other site 997761004265 Protein of unknown function (DUF1427); Region: DUF1427; cl01771 997761004266 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 997761004267 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 997761004268 putative ligand binding site [chemical binding]; other site 997761004269 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 997761004270 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 997761004271 Walker A/P-loop; other site 997761004272 ATP binding site [chemical binding]; other site 997761004273 Q-loop/lid; other site 997761004274 ABC transporter signature motif; other site 997761004275 Walker B; other site 997761004276 D-loop; other site 997761004277 H-loop/switch region; other site 997761004278 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 997761004279 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761004280 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 997761004281 TM-ABC transporter signature motif; other site 997761004282 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761004283 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 997761004284 TM-ABC transporter signature motif; other site 997761004285 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 997761004286 nucleoside/Zn binding site; other site 997761004287 dimer interface [polypeptide binding]; other site 997761004288 catalytic motif [active] 997761004289 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761004290 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761004291 dimer interface [polypeptide binding]; other site 997761004292 putative CheW interface [polypeptide binding]; other site 997761004293 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 997761004294 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 997761004295 putative substrate binding site [chemical binding]; other site 997761004296 putative ATP binding site [chemical binding]; other site 997761004297 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 997761004298 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 997761004299 Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936 997761004300 Acyltransferase family; Region: Acyl_transf_3; pfam01757 997761004301 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761004302 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761004303 active site 997761004304 phosphorylation site [posttranslational modification] 997761004305 intermolecular recognition site; other site 997761004306 dimerization interface [polypeptide binding]; other site 997761004307 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761004308 DNA binding site [nucleotide binding] 997761004309 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761004310 dimerization interface [polypeptide binding]; other site 997761004311 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761004312 dimer interface [polypeptide binding]; other site 997761004313 phosphorylation site [posttranslational modification] 997761004314 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761004315 ATP binding site [chemical binding]; other site 997761004316 Mg2+ binding site [ion binding]; other site 997761004317 G-X-G motif; other site 997761004318 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 997761004319 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 997761004320 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 997761004321 S-layer homology domain; Region: SLH; pfam00395 997761004322 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 997761004323 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 997761004324 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 997761004325 Intracellular proteinase inhibitor; Region: BsuPI; pfam12690 997761004326 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761004327 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761004328 metal binding site [ion binding]; metal-binding site 997761004329 active site 997761004330 I-site; other site 997761004331 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 997761004332 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761004333 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 997761004334 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 997761004335 putative active site [active] 997761004336 putative metal binding site [ion binding]; other site 997761004337 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 997761004338 Domain of unknown function (DUF1200); Region: DUF1200; pfam06713 997761004339 VanW like protein; Region: VanW; pfam04294 997761004340 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 997761004341 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 997761004342 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761004343 Coenzyme A binding pocket [chemical binding]; other site 997761004344 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 997761004345 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 997761004346 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 997761004347 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 997761004348 DinB family; Region: DinB; cl17821 997761004349 DinB superfamily; Region: DinB_2; pfam12867 997761004350 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 997761004351 NlpC/P60 family; Region: NLPC_P60; pfam00877 997761004352 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 997761004353 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761004354 DNA-binding site [nucleotide binding]; DNA binding site 997761004355 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761004356 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 997761004357 putative ligand binding site [chemical binding]; other site 997761004358 putative dimerization interface [polypeptide binding]; other site 997761004359 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 997761004360 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 997761004361 intersubunit interface [polypeptide binding]; other site 997761004362 active site 997761004363 Zn2+ binding site [ion binding]; other site 997761004364 ribulokinase; Provisional; Region: PRK04123 997761004365 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 997761004366 N- and C-terminal domain interface [polypeptide binding]; other site 997761004367 active site 997761004368 MgATP binding site [chemical binding]; other site 997761004369 catalytic site [active] 997761004370 metal binding site [ion binding]; metal-binding site 997761004371 carbohydrate binding site [chemical binding]; other site 997761004372 homodimer interface [polypeptide binding]; other site 997761004373 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 997761004374 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 997761004375 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 997761004376 nucleotide binding site/active site [active] 997761004377 HIT family signature motif; other site 997761004378 catalytic residue [active] 997761004379 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761004380 Radical SAM superfamily; Region: Radical_SAM; pfam04055 997761004381 FeS/SAM binding site; other site 997761004382 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 997761004383 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761004384 MarR family; Region: MarR; pfam01047 997761004385 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 997761004386 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 997761004387 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 997761004388 nucleotide binding site [chemical binding]; other site 997761004389 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 997761004390 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 997761004391 Tetratricopeptide repeat; Region: TPR_16; pfam13432 997761004392 binding surface 997761004393 TPR motif; other site 997761004394 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 997761004395 binding surface 997761004396 TPR motif; other site 997761004397 Tetratricopeptide repeat; Region: TPR_16; pfam13432 997761004398 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 997761004399 dimer interface [polypeptide binding]; other site 997761004400 substrate binding site [chemical binding]; other site 997761004401 ATP binding site [chemical binding]; other site 997761004402 Uncharacterized conserved protein [Function unknown]; Region: COG2445 997761004403 Predicted transcriptional regulator [Transcription]; Region: COG2345 997761004404 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761004405 putative DNA binding site [nucleotide binding]; other site 997761004406 putative Zn2+ binding site [ion binding]; other site 997761004407 Transcriptional regulator [Transcription]; Region: LytR; COG1316 997761004408 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761004409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761004410 active site 997761004411 phosphorylation site [posttranslational modification] 997761004412 intermolecular recognition site; other site 997761004413 dimerization interface [polypeptide binding]; other site 997761004414 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761004415 DNA binding site [nucleotide binding] 997761004416 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761004417 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761004418 dimerization interface [polypeptide binding]; other site 997761004419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761004420 dimer interface [polypeptide binding]; other site 997761004421 phosphorylation site [posttranslational modification] 997761004422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761004423 ATP binding site [chemical binding]; other site 997761004424 Mg2+ binding site [ion binding]; other site 997761004425 G-X-G motif; other site 997761004426 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 997761004427 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 997761004428 active site 997761004429 intersubunit interface [polypeptide binding]; other site 997761004430 catalytic residue [active] 997761004431 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 997761004432 YtxH-like protein; Region: YtxH; pfam12732 997761004433 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 997761004434 LytTr DNA-binding domain; Region: LytTR; cl04498 997761004435 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761004436 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761004437 metal binding site [ion binding]; metal-binding site 997761004438 active site 997761004439 I-site; other site 997761004440 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 997761004441 Helix-turn-helix; Region: HTH_3; pfam01381 997761004442 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 997761004443 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 997761004444 Family description; Region: VCBS; pfam13517 997761004445 Family description; Region: VCBS; pfam13517 997761004446 Family description; Region: VCBS; pfam13517 997761004447 Family description; Region: VCBS; pfam13517 997761004448 Family description; Region: VCBS; pfam13517 997761004449 Family description; Region: VCBS; pfam13517 997761004450 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 997761004451 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102 997761004452 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 997761004453 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 997761004454 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 997761004455 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761004456 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004457 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761004458 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004459 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 997761004460 alpha-galactosidase; Provisional; Region: PRK15076 997761004461 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 997761004462 NAD binding site [chemical binding]; other site 997761004463 sugar binding site [chemical binding]; other site 997761004464 divalent metal binding site [ion binding]; other site 997761004465 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 997761004466 dimer interface [polypeptide binding]; other site 997761004467 glutamate racemase; Provisional; Region: PRK00865 997761004468 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 997761004469 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 997761004470 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 997761004471 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 997761004472 putative active site [active] 997761004473 Zn binding site [ion binding]; other site 997761004474 Domain of unknown function (DUF377); Region: DUF377; pfam04041 997761004475 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 997761004476 active site 997761004477 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761004478 Helix-turn-helix domain; Region: HTH_18; pfam12833 997761004479 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004480 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 997761004481 Domain of unknown function DUF20; Region: UPF0118; pfam01594 997761004482 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761004483 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761004484 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 997761004485 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 997761004486 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761004487 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 997761004488 SdiA-regulated; Region: SdiA-regulated; cd09971 997761004489 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 997761004490 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 997761004491 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 997761004492 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 997761004493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 997761004494 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 997761004495 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761004496 S-adenosylmethionine binding site [chemical binding]; other site 997761004497 DinB family; Region: DinB; cl17821 997761004498 DinB superfamily; Region: DinB_2; pfam12867 997761004499 drug efflux system protein MdtG; Provisional; Region: PRK09874 997761004500 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761004501 putative substrate translocation pore; other site 997761004502 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 997761004503 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 997761004504 active site 997761004505 metal binding site [ion binding]; metal-binding site 997761004506 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 997761004507 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 997761004508 putative active site [active] 997761004509 putative metal binding site [ion binding]; other site 997761004510 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 997761004511 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 997761004512 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 997761004513 oligoendopeptidase F; Region: pepF; TIGR00181 997761004514 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 997761004515 active site 997761004516 Zn binding site [ion binding]; other site 997761004517 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 997761004518 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 997761004519 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 997761004520 DNA-binding site [nucleotide binding]; DNA binding site 997761004521 RNA-binding motif; other site 997761004522 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 997761004523 FMN binding site [chemical binding]; other site 997761004524 dimer interface [polypeptide binding]; other site 997761004525 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 997761004526 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 997761004527 Sulfate transporter family; Region: Sulfate_transp; pfam00916 997761004528 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 997761004529 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 997761004530 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 997761004531 FtsX-like permease family; Region: FtsX; pfam02687 997761004532 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 997761004533 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 997761004534 Walker A/P-loop; other site 997761004535 ATP binding site [chemical binding]; other site 997761004536 Q-loop/lid; other site 997761004537 ABC transporter signature motif; other site 997761004538 Walker B; other site 997761004539 D-loop; other site 997761004540 H-loop/switch region; other site 997761004541 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761004542 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761004543 putative substrate translocation pore; other site 997761004544 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 997761004545 6-phosphofructokinase; Provisional; Region: PRK03202 997761004546 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 997761004547 active site 997761004548 ADP/pyrophosphate binding site [chemical binding]; other site 997761004549 dimerization interface [polypeptide binding]; other site 997761004550 allosteric effector site; other site 997761004551 fructose-1,6-bisphosphate binding site; other site 997761004552 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 997761004553 Predicted flavoprotein [General function prediction only]; Region: COG0431 997761004554 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 997761004555 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 997761004556 ligand binding site [chemical binding]; other site 997761004557 active site 997761004558 UGI interface [polypeptide binding]; other site 997761004559 catalytic site [active] 997761004560 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 997761004561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761004562 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761004563 putative substrate translocation pore; other site 997761004564 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 997761004565 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 997761004566 Uncharacterized conserved protein [Function unknown]; Region: COG1284 997761004567 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 997761004568 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 997761004569 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 997761004570 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 997761004571 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 997761004572 helicase 45; Provisional; Region: PTZ00424 997761004573 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 997761004574 ATP binding site [chemical binding]; other site 997761004575 Mg++ binding site [ion binding]; other site 997761004576 motif III; other site 997761004577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 997761004578 nucleotide binding region [chemical binding]; other site 997761004579 ATP-binding site [chemical binding]; other site 997761004580 Protein of unknown function, DUF624; Region: DUF624; cl02369 997761004581 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 997761004582 active site 997761004583 intersubunit interactions; other site 997761004584 catalytic residue [active] 997761004585 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 997761004586 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 997761004587 dimer interface [polypeptide binding]; other site 997761004588 catalytic triad [active] 997761004589 peroxidatic and resolving cysteines [active] 997761004590 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761004591 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761004592 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 997761004593 putative dimerization interface [polypeptide binding]; other site 997761004594 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 997761004595 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 997761004596 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 997761004597 Predicted Zn-dependent protease [General function prediction only]; Region: COG2738 997761004598 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 997761004599 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 997761004600 metal binding triad; other site 997761004601 Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335 997761004602 hypothetical protein; Provisional; Region: PRK07740 997761004603 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 997761004604 active site 997761004605 catalytic site [active] 997761004606 substrate binding site [chemical binding]; other site 997761004607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761004608 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761004609 putative substrate translocation pore; other site 997761004610 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 997761004611 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 997761004612 catalytic residues [active] 997761004613 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 997761004614 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 997761004615 active site 997761004616 catalytic residues [active] 997761004617 metal binding site [ion binding]; metal-binding site 997761004618 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 997761004619 DNA polymerase IV; Validated; Region: PRK01810 997761004620 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 997761004621 active site 997761004622 DNA binding site [nucleotide binding] 997761004623 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 997761004624 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 997761004625 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 997761004626 CHASE2 domain; Region: CHASE2; pfam05226 997761004627 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 997761004628 cyclase homology domain; Region: CHD; cd07302 997761004629 nucleotidyl binding site; other site 997761004630 metal binding site [ion binding]; metal-binding site 997761004631 dimer interface [polypeptide binding]; other site 997761004632 FecR protein; Region: FecR; pfam04773 997761004633 NHL repeat; Region: NHL; pfam01436 997761004634 NHL repeat; Region: NHL; pfam01436 997761004635 NHL repeat; Region: NHL; pfam01436 997761004636 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761004637 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 997761004638 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 997761004639 quinone interaction residues [chemical binding]; other site 997761004640 active site 997761004641 catalytic residues [active] 997761004642 FMN binding site [chemical binding]; other site 997761004643 substrate binding site [chemical binding]; other site 997761004644 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 997761004645 synthetase active site [active] 997761004646 NTP binding site [chemical binding]; other site 997761004647 metal binding site [ion binding]; metal-binding site 997761004648 Domain of unknown function (DUF309); Region: DUF309; pfam03745 997761004649 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 997761004650 catalytic residues [active] 997761004651 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 997761004652 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 997761004653 RNA binding surface [nucleotide binding]; other site 997761004654 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 997761004655 active site 997761004656 uracil binding [chemical binding]; other site 997761004657 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 997761004658 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761004659 active site 997761004660 motif I; other site 997761004661 motif II; other site 997761004662 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 997761004663 CsbD-like; Region: CsbD; cl17424 997761004664 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 997761004665 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761004666 S-adenosylmethionine binding site [chemical binding]; other site 997761004667 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 997761004668 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 997761004669 active site 997761004670 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963 997761004671 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761004672 FeS/SAM binding site; other site 997761004673 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 997761004674 Ligand Binding Site [chemical binding]; other site 997761004675 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 997761004676 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761004677 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761004678 metal binding site [ion binding]; metal-binding site 997761004679 active site 997761004680 I-site; other site 997761004681 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761004682 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 997761004683 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 997761004684 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761004685 NAD(P) binding site [chemical binding]; other site 997761004686 active site 997761004687 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 997761004688 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 997761004689 active site 997761004690 Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955 997761004691 Transcriptional regulator [Transcription]; Region: LytR; COG1316 997761004692 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022 997761004693 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 997761004694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761004695 Coenzyme A binding pocket [chemical binding]; other site 997761004696 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 997761004697 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 997761004698 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 997761004699 active site 997761004700 HIGH motif; other site 997761004701 KMSK motif region; other site 997761004702 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 997761004703 tRNA binding surface [nucleotide binding]; other site 997761004704 anticodon binding site; other site 997761004705 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 997761004706 YqzE-like protein; Region: YqzE; pfam14038 997761004707 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 997761004708 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 997761004709 transmembrane helices; other site 997761004710 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 997761004711 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 997761004712 ATP binding site [chemical binding]; other site 997761004713 putative Mg++ binding site [ion binding]; other site 997761004714 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 997761004715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 997761004716 nucleotide binding region [chemical binding]; other site 997761004717 ATP-binding site [chemical binding]; other site 997761004718 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 997761004719 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 997761004720 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 997761004721 homodimer interface [polypeptide binding]; other site 997761004722 substrate-cofactor binding pocket; other site 997761004723 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761004724 catalytic residue [active] 997761004725 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 997761004726 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 997761004727 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 997761004728 active site 997761004729 dimer interface [polypeptide binding]; other site 997761004730 effector binding site; other site 997761004731 TSCPD domain; Region: TSCPD; pfam12637 997761004732 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761004733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004734 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761004735 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004736 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761004737 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761004738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004739 dimer interface [polypeptide binding]; other site 997761004740 conserved gate region; other site 997761004741 putative PBP binding loops; other site 997761004742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761004743 ABC-ATPase subunit interface; other site 997761004744 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761004745 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004746 dimer interface [polypeptide binding]; other site 997761004747 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 997761004748 ABC-ATPase subunit interface; other site 997761004749 beta-D-glucuronidase; Provisional; Region: PRK10150 997761004750 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 997761004751 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 997761004752 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 997761004753 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 997761004754 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 997761004755 catalytic tetrad [active] 997761004756 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 997761004757 hypothetical protein; Provisional; Region: PRK06184 997761004758 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 997761004759 MarR family; Region: MarR_2; cl17246 997761004760 Tryptophan-rich protein (DUF2389); Region: DUF2389; cl09726 997761004761 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 997761004762 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 997761004763 active site 997761004764 homotetramer interface [polypeptide binding]; other site 997761004765 homodimer interface [polypeptide binding]; other site 997761004766 Protein of unknown function (DUF3139); Region: DUF3139; pfam11337 997761004767 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 997761004768 hypothetical protein; Provisional; Region: PRK07236 997761004769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761004770 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 997761004771 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 997761004772 hypothetical protein; Provisional; Region: PRK09739 997761004773 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 997761004774 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761004775 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761004776 Erythromycin esterase; Region: Erythro_esteras; pfam05139 997761004777 Erythromycin esterase; Region: Erythro_esteras; pfam05139 997761004778 Chromate transporter; Region: Chromate_transp; pfam02417 997761004779 Chromate transporter; Region: Chromate_transp; pfam02417 997761004780 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761004781 Cache domain; Region: Cache_1; pfam02743 997761004782 HAMP domain; Region: HAMP; pfam00672 997761004783 Histidine kinase; Region: His_kinase; pfam06580 997761004784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761004785 ATP binding site [chemical binding]; other site 997761004786 Mg2+ binding site [ion binding]; other site 997761004787 G-X-G motif; other site 997761004788 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 997761004789 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 997761004790 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 997761004791 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 997761004792 Sulfatase; Region: Sulfatase; pfam00884 997761004793 Uncharacterized conserved protein [Function unknown]; Region: COG1262 997761004794 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 997761004795 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761004796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004797 Cupin domain; Region: Cupin_2; pfam07883 997761004798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004799 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761004800 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004801 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761004802 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761004803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004804 dimer interface [polypeptide binding]; other site 997761004805 conserved gate region; other site 997761004806 putative PBP binding loops; other site 997761004807 ABC-ATPase subunit interface; other site 997761004808 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761004809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004810 dimer interface [polypeptide binding]; other site 997761004811 conserved gate region; other site 997761004812 putative PBP binding loops; other site 997761004813 ABC-ATPase subunit interface; other site 997761004814 Right handed beta helix region; Region: Beta_helix; pfam13229 997761004815 Bulb-type mannose-specific lectin; Region: B_lectin; smart00108 997761004816 Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028 997761004817 dimerization interface [polypeptide binding]; other site 997761004818 mannose binding site [chemical binding]; other site 997761004819 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761004820 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761004821 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004822 dimer interface [polypeptide binding]; other site 997761004823 conserved gate region; other site 997761004824 putative PBP binding loops; other site 997761004825 ABC-ATPase subunit interface; other site 997761004826 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761004827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004828 dimer interface [polypeptide binding]; other site 997761004829 conserved gate region; other site 997761004830 putative PBP binding loops; other site 997761004831 ABC-ATPase subunit interface; other site 997761004832 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 997761004833 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 997761004834 inhibitor binding site; inhibition site 997761004835 active site 997761004836 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 997761004837 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 997761004838 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 997761004839 catalytic site [active] 997761004840 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 997761004841 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761004842 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761004843 dimerization interface [polypeptide binding]; other site 997761004844 Histidine kinase; Region: His_kinase; pfam06580 997761004845 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761004846 ATP binding site [chemical binding]; other site 997761004847 Mg2+ binding site [ion binding]; other site 997761004848 G-X-G motif; other site 997761004849 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761004850 Response regulator receiver domain; Region: Response_reg; pfam00072 997761004851 active site 997761004852 phosphorylation site [posttranslational modification] 997761004853 intermolecular recognition site; other site 997761004854 dimerization interface [polypeptide binding]; other site 997761004855 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004856 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761004857 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004858 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761004859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004860 dimer interface [polypeptide binding]; other site 997761004861 conserved gate region; other site 997761004862 putative PBP binding loops; other site 997761004863 ABC-ATPase subunit interface; other site 997761004864 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761004865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004866 dimer interface [polypeptide binding]; other site 997761004867 conserved gate region; other site 997761004868 putative PBP binding loops; other site 997761004869 ABC-ATPase subunit interface; other site 997761004870 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 997761004871 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761004872 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761004873 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004874 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 997761004875 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 997761004876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761004877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 997761004878 Coenzyme A binding pocket [chemical binding]; other site 997761004879 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 997761004880 conserved cys residue [active] 997761004881 atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262 997761004882 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 997761004883 putative NAD(P) binding site [chemical binding]; other site 997761004884 hypothetical protein; Provisional; Region: PRK06184 997761004885 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 997761004886 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 997761004887 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004888 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761004889 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004890 Cupin domain; Region: Cupin_2; cl17218 997761004891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004892 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761004893 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004894 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 997761004895 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761004896 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761004897 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004898 Creatinine amidohydrolase; Region: Creatininase; pfam02633 997761004899 beta-D-glucuronidase; Provisional; Region: PRK10150 997761004900 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 997761004901 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 997761004902 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 997761004903 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 997761004904 classical (c) SDRs; Region: SDR_c; cd05233 997761004905 NAD(P) binding site [chemical binding]; other site 997761004906 active site 997761004907 NADH(P)-binding; Region: NAD_binding_10; pfam13460 997761004908 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 997761004909 NADP binding site [chemical binding]; other site 997761004910 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761004911 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761004912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004914 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 997761004915 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 997761004916 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 997761004917 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761004918 Interdomain contacts; other site 997761004919 Cytokine receptor motif; other site 997761004920 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761004921 Interdomain contacts; other site 997761004922 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761004923 Interdomain contacts; other site 997761004924 Cytokine receptor motif; other site 997761004925 Melibiase; Region: Melibiase; pfam02065 997761004926 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 997761004927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761004928 active site 997761004929 phosphorylation site [posttranslational modification] 997761004930 intermolecular recognition site; other site 997761004931 dimerization interface [polypeptide binding]; other site 997761004932 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004933 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004934 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761004935 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761004936 dimerization interface [polypeptide binding]; other site 997761004937 Histidine kinase; Region: His_kinase; pfam06580 997761004938 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761004939 ATP binding site [chemical binding]; other site 997761004940 Mg2+ binding site [ion binding]; other site 997761004941 G-X-G motif; other site 997761004942 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761004943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004944 dimer interface [polypeptide binding]; other site 997761004945 conserved gate region; other site 997761004946 ABC-ATPase subunit interface; other site 997761004947 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761004948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004949 ABC-ATPase subunit interface; other site 997761004950 Right handed beta helix region; Region: Beta_helix; pfam13229 997761004951 Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752 997761004952 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 997761004953 Cupin domain; Region: Cupin_2; pfam07883 997761004954 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004955 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761004956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004957 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761004958 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761004959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004960 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761004961 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761004962 alpha-mannosidase; Provisional; Region: PRK09819 997761004963 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 997761004964 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 997761004965 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 997761004966 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761004967 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761004968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004969 PAS fold; Region: PAS_4; pfam08448 997761004970 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761004971 putative active site [active] 997761004972 heme pocket [chemical binding]; other site 997761004973 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761004974 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761004975 metal binding site [ion binding]; metal-binding site 997761004976 active site 997761004977 I-site; other site 997761004978 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 997761004979 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 997761004980 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761004981 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761004982 metal binding site [ion binding]; metal-binding site 997761004983 active site 997761004984 I-site; other site 997761004985 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 997761004986 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 997761004987 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 997761004988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004989 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761004990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761004991 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 997761004992 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761004993 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761004994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004995 putative PBP binding loops; other site 997761004996 ABC-ATPase subunit interface; other site 997761004997 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761004998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761004999 dimer interface [polypeptide binding]; other site 997761005000 conserved gate region; other site 997761005001 ABC-ATPase subunit interface; other site 997761005002 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761005003 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005004 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761005005 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761005006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005008 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159 997761005009 Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146 997761005010 iron-sulfur cluster [ion binding]; other site 997761005011 [2Fe-2S] cluster binding site [ion binding]; other site 997761005012 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 997761005013 Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934 997761005014 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005016 dimer interface [polypeptide binding]; other site 997761005017 conserved gate region; other site 997761005018 ABC-ATPase subunit interface; other site 997761005019 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005020 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005021 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 997761005022 HEAT repeats; Region: HEAT_2; pfam13646 997761005023 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761005024 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761005025 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005026 2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410 997761005027 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 997761005028 putative ligand binding site [chemical binding]; other site 997761005029 putative NAD binding site [chemical binding]; other site 997761005030 catalytic site [active] 997761005031 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 997761005032 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 997761005033 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 997761005034 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 997761005035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005036 Helix-turn-helix domain; Region: HTH_18; pfam12833 997761005037 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 997761005038 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761005039 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005040 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761005041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005042 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761005043 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761005044 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761005045 dimerization interface [polypeptide binding]; other site 997761005046 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761005047 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761005048 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761005049 dimerization interface [polypeptide binding]; other site 997761005050 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 997761005051 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005052 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761005053 dimerization interface [polypeptide binding]; other site 997761005054 Histidine kinase; Region: His_kinase; pfam06580 997761005055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761005056 ATP binding site [chemical binding]; other site 997761005057 Mg2+ binding site [ion binding]; other site 997761005058 G-X-G motif; other site 997761005059 Response regulator receiver domain; Region: Response_reg; pfam00072 997761005060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761005061 active site 997761005062 phosphorylation site [posttranslational modification] 997761005063 intermolecular recognition site; other site 997761005064 dimerization interface [polypeptide binding]; other site 997761005065 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761005066 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005067 PKD domain; Region: PKD; pfam00801 997761005068 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005069 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005070 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761005071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761005072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005073 dimer interface [polypeptide binding]; other site 997761005074 ABC-ATPase subunit interface; other site 997761005075 putative PBP binding loops; other site 997761005076 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 997761005077 active site 997761005078 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 997761005079 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 997761005080 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 997761005081 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 997761005082 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 997761005083 active site 997761005084 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 997761005085 active site 997761005086 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 997761005087 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 997761005088 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761005089 Interdomain contacts; other site 997761005090 Cytokine receptor motif; other site 997761005091 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 997761005092 dockerin binding interface; other site 997761005093 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 997761005094 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 997761005095 DNA binding residues [nucleotide binding] 997761005096 dimer interface [polypeptide binding]; other site 997761005097 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_7; cd08900 997761005098 putative hydrophobic ligand binding site [chemical binding]; other site 997761005099 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894 997761005100 putative hydrophobic ligand binding site [chemical binding]; other site 997761005101 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 997761005102 classical (c) SDRs; Region: SDR_c; cd05233 997761005103 NAD(P) binding site [chemical binding]; other site 997761005104 active site 997761005105 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 997761005106 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005107 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761005108 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 997761005109 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 997761005110 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761005111 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761005112 LytTr DNA-binding domain; Region: LytTR; smart00850 997761005113 stage V sporulation protein B; Region: spore_V_B; TIGR02900 997761005114 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 997761005115 Transcription antiterminator [Transcription]; Region: NusG; COG0250 997761005116 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 997761005117 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 997761005118 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 997761005119 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 997761005120 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 997761005121 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 997761005122 FMN binding site [chemical binding]; other site 997761005123 substrate binding site [chemical binding]; other site 997761005124 putative catalytic residue [active] 997761005125 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 997761005126 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 997761005127 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 997761005128 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 997761005129 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 997761005130 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 997761005131 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761005132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005133 dimer interface [polypeptide binding]; other site 997761005134 conserved gate region; other site 997761005135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761005136 ABC-ATPase subunit interface; other site 997761005137 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005139 dimer interface [polypeptide binding]; other site 997761005140 conserved gate region; other site 997761005141 putative PBP binding loops; other site 997761005142 ABC-ATPase subunit interface; other site 997761005143 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005144 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 997761005145 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 997761005146 substrate binding [chemical binding]; other site 997761005147 active site 997761005148 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 997761005149 Sporulation inhibitor A; Region: Sda; pfam08970 997761005150 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 997761005151 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 997761005152 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 997761005153 substrate binding [chemical binding]; other site 997761005154 active site 997761005155 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 997761005156 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 997761005157 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 997761005158 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761005159 putative substrate translocation pore; other site 997761005160 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 997761005161 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 997761005162 inhibitor-cofactor binding pocket; inhibition site 997761005163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761005164 catalytic residue [active] 997761005165 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 997761005166 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 997761005167 NAD(P) binding site [chemical binding]; other site 997761005168 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 997761005169 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761005170 motif II; other site 997761005171 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 997761005172 active site 997761005173 Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253 997761005174 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 997761005175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408 997761005176 Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100 997761005177 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 997761005178 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 997761005179 substrate binding site [chemical binding]; other site 997761005180 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 997761005181 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005182 dimer interface [polypeptide binding]; other site 997761005183 conserved gate region; other site 997761005184 putative PBP binding loops; other site 997761005185 ABC-ATPase subunit interface; other site 997761005186 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 997761005187 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 997761005188 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005189 dimer interface [polypeptide binding]; other site 997761005190 conserved gate region; other site 997761005191 putative PBP binding loops; other site 997761005192 ABC-ATPase subunit interface; other site 997761005193 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 997761005194 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 997761005195 Walker A/P-loop; other site 997761005196 ATP binding site [chemical binding]; other site 997761005197 Q-loop/lid; other site 997761005198 ABC transporter signature motif; other site 997761005199 Walker B; other site 997761005200 D-loop; other site 997761005201 H-loop/switch region; other site 997761005202 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 997761005203 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 997761005204 Walker A/P-loop; other site 997761005205 ATP binding site [chemical binding]; other site 997761005206 Q-loop/lid; other site 997761005207 ABC transporter signature motif; other site 997761005208 Walker B; other site 997761005209 D-loop; other site 997761005210 H-loop/switch region; other site 997761005211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761005212 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761005213 putative substrate translocation pore; other site 997761005214 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761005215 dimerization interface [polypeptide binding]; other site 997761005216 putative DNA binding site [nucleotide binding]; other site 997761005217 putative Zn2+ binding site [ion binding]; other site 997761005218 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 997761005219 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 997761005220 metal-binding site [ion binding] 997761005221 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 997761005222 Soluble P-type ATPase [General function prediction only]; Region: COG4087 997761005223 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 997761005224 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 997761005225 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 997761005226 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761005227 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 997761005228 dimerization interface [polypeptide binding]; other site 997761005229 substrate binding pocket [chemical binding]; other site 997761005230 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761005231 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 997761005232 NAD(P) binding site [chemical binding]; other site 997761005233 active site 997761005234 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 997761005235 Helix-turn-helix domain; Region: HTH_18; pfam12833 997761005236 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005237 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 997761005238 classical (c) SDRs; Region: SDR_c; cd05233 997761005239 NAD(P) binding site [chemical binding]; other site 997761005240 active site 997761005241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761005242 Walker A/P-loop; other site 997761005243 ATP binding site [chemical binding]; other site 997761005244 Q-loop/lid; other site 997761005245 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 997761005246 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 997761005247 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761005248 Walker A/P-loop; other site 997761005249 ATP binding site [chemical binding]; other site 997761005250 Q-loop/lid; other site 997761005251 ABC transporter signature motif; other site 997761005252 Walker B; other site 997761005253 D-loop; other site 997761005254 H-loop/switch region; other site 997761005255 DinB family; Region: DinB; cl17821 997761005256 DinB superfamily; Region: DinB_2; pfam12867 997761005257 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 997761005258 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 997761005259 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 997761005260 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 997761005261 Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718 997761005262 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 997761005263 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 997761005264 substrate binding site [chemical binding]; other site 997761005265 ATP binding site [chemical binding]; other site 997761005266 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 997761005267 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 997761005268 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 997761005269 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 997761005270 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 997761005271 active site 997761005272 dimerization interface [polypeptide binding]; other site 997761005273 Cobalt transport protein; Region: CbiQ; cl00463 997761005274 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 997761005275 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 997761005276 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761005277 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761005278 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761005279 dimerization interface [polypeptide binding]; other site 997761005280 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 997761005281 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 997761005282 Protein of unknown function (DUF1572); Region: DUF1572; pfam07609 997761005283 DinB superfamily; Region: DinB_2; pfam12867 997761005284 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761005285 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761005286 NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251 997761005287 NmrA-like family; Region: NmrA; pfam05368 997761005288 NADP binding site [chemical binding]; other site 997761005289 active site 997761005290 regulatory binding site [polypeptide binding]; other site 997761005291 hypothetical protein; Validated; Region: PRK06186 997761005292 conserved cys residue [active] 997761005293 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005294 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005295 Response regulator receiver domain; Region: Response_reg; pfam00072 997761005296 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761005297 active site 997761005298 phosphorylation site [posttranslational modification] 997761005299 intermolecular recognition site; other site 997761005300 dimerization interface [polypeptide binding]; other site 997761005301 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761005302 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005303 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005304 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 997761005305 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 997761005306 substrate binding [chemical binding]; other site 997761005307 active site 997761005308 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 997761005309 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761005310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005311 putative PBP binding loops; other site 997761005312 ABC-ATPase subunit interface; other site 997761005313 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005314 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005315 dimer interface [polypeptide binding]; other site 997761005316 conserved gate region; other site 997761005317 putative PBP binding loops; other site 997761005318 ABC-ATPase subunit interface; other site 997761005319 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 997761005320 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 997761005321 substrate binding [chemical binding]; other site 997761005322 active site 997761005323 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 997761005324 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 997761005325 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 997761005326 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 997761005327 substrate binding [chemical binding]; other site 997761005328 active site 997761005329 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 997761005330 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761005331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761005332 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 997761005333 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 997761005334 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761005335 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761005336 QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360 997761005337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761005338 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761005339 putative substrate translocation pore; other site 997761005340 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 997761005341 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761005342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005343 dimer interface [polypeptide binding]; other site 997761005344 conserved gate region; other site 997761005345 ABC-ATPase subunit interface; other site 997761005346 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005348 dimer interface [polypeptide binding]; other site 997761005349 conserved gate region; other site 997761005350 putative PBP binding loops; other site 997761005351 ABC-ATPase subunit interface; other site 997761005352 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005353 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005354 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761005355 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761005356 Predicted membrane protein [Function unknown]; Region: COG4270 997761005357 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 997761005358 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 997761005359 putative NAD(P) binding site [chemical binding]; other site 997761005360 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 997761005361 active site 997761005362 catalytic triad [active] 997761005363 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 997761005364 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 997761005365 putative active cleft [active] 997761005366 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761005367 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005368 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761005369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005370 dimer interface [polypeptide binding]; other site 997761005371 conserved gate region; other site 997761005372 ABC-ATPase subunit interface; other site 997761005373 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005374 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005375 dimer interface [polypeptide binding]; other site 997761005376 conserved gate region; other site 997761005377 putative PBP binding loops; other site 997761005378 ABC-ATPase subunit interface; other site 997761005379 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005380 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 997761005381 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761005382 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761005383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005384 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761005385 Interdomain contacts; other site 997761005386 Cytokine receptor motif; other site 997761005387 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 997761005388 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 997761005389 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 997761005390 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 997761005391 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321 997761005392 putative ligand binding site [chemical binding]; other site 997761005393 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 997761005394 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 997761005395 Walker A/P-loop; other site 997761005396 ATP binding site [chemical binding]; other site 997761005397 Q-loop/lid; other site 997761005398 ABC transporter signature motif; other site 997761005399 Walker B; other site 997761005400 D-loop; other site 997761005401 H-loop/switch region; other site 997761005402 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 997761005403 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761005404 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 997761005405 TM-ABC transporter signature motif; other site 997761005406 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761005407 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761005408 DNA binding site [nucleotide binding] 997761005409 domain linker motif; other site 997761005410 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 997761005411 dimerization interface [polypeptide binding]; other site 997761005412 ligand binding site [chemical binding]; other site 997761005413 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761005414 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761005415 DNA binding site [nucleotide binding] 997761005416 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 997761005417 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761005418 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005419 ABC-ATPase subunit interface; other site 997761005420 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005422 dimer interface [polypeptide binding]; other site 997761005423 conserved gate region; other site 997761005424 putative PBP binding loops; other site 997761005425 ABC-ATPase subunit interface; other site 997761005426 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005427 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005428 Isochorismatase family; Region: Isochorismatase; pfam00857 997761005429 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 997761005430 catalytic triad [active] 997761005431 dimer interface [polypeptide binding]; other site 997761005432 conserved cis-peptide bond; other site 997761005433 Protein of unknown function (DUF1427); Region: DUF1427; pfam07235 997761005434 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 997761005435 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 997761005436 active site 997761005437 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 997761005438 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 997761005439 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 997761005440 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 997761005441 dimerization interface [polypeptide binding]; other site 997761005442 DPS ferroxidase diiron center [ion binding]; other site 997761005443 ion pore; other site 997761005444 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 997761005445 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 997761005446 substrate binding pocket [chemical binding]; other site 997761005447 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 997761005448 Predicted esterase [General function prediction only]; Region: COG0400 997761005449 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 997761005450 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 997761005451 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 997761005452 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 997761005453 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761005454 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761005455 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005456 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005457 Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401 997761005458 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 997761005459 Transposase; Region: DEDD_Tnp_IS110; pfam01548 997761005460 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 997761005461 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 997761005462 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 997761005463 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 997761005464 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 997761005465 putative DNA binding site [nucleotide binding]; other site 997761005466 putative Zn2+ binding site [ion binding]; other site 997761005467 AsnC family; Region: AsnC_trans_reg; pfam01037 997761005468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761005469 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761005470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761005471 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 997761005472 putative substrate translocation pore; other site 997761005473 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761005474 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005475 dimer interface [polypeptide binding]; other site 997761005476 conserved gate region; other site 997761005477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761005478 ABC-ATPase subunit interface; other site 997761005479 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005480 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005481 dimer interface [polypeptide binding]; other site 997761005482 conserved gate region; other site 997761005483 putative PBP binding loops; other site 997761005484 ABC-ATPase subunit interface; other site 997761005485 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005486 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005487 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761005488 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005489 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 997761005490 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761005491 ABC-ATPase subunit interface; other site 997761005492 dimer interface [polypeptide binding]; other site 997761005493 putative PBP binding regions; other site 997761005494 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 997761005495 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761005496 ABC-ATPase subunit interface; other site 997761005497 dimer interface [polypeptide binding]; other site 997761005498 putative PBP binding regions; other site 997761005499 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 997761005500 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 997761005501 intersubunit interface [polypeptide binding]; other site 997761005502 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 997761005503 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 997761005504 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 997761005505 metal binding site [ion binding]; metal-binding site 997761005506 active site 997761005507 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761005508 Interdomain contacts; other site 997761005509 Cytokine receptor motif; other site 997761005510 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761005511 Interdomain contacts; other site 997761005512 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 997761005513 dockerin binding interface; other site 997761005514 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 997761005515 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 997761005516 inhibitor binding site; inhibition site 997761005517 catalytic Zn binding site [ion binding]; other site 997761005518 structural Zn binding site [ion binding]; other site 997761005519 NADP binding site [chemical binding]; other site 997761005520 tetramer interface [polypeptide binding]; other site 997761005521 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 997761005522 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 997761005523 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761005524 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761005525 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761005526 Spore germination protein; Region: Spore_permease; cl17796 997761005527 SET domain; Region: SET; pfam00856 997761005528 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 997761005529 putative hydrophobic ligand binding site [chemical binding]; other site 997761005530 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761005531 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005532 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005533 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005534 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761005535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005536 dimer interface [polypeptide binding]; other site 997761005537 conserved gate region; other site 997761005538 putative PBP binding loops; other site 997761005539 ABC-ATPase subunit interface; other site 997761005540 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005542 dimer interface [polypeptide binding]; other site 997761005543 conserved gate region; other site 997761005544 ABC-ATPase subunit interface; other site 997761005545 Transcriptional regulators [Transcription]; Region: GntR; COG1802 997761005546 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761005547 DNA-binding site [nucleotide binding]; DNA binding site 997761005548 FCD domain; Region: FCD; pfam07729 997761005549 mannonate dehydratase; Provisional; Region: PRK03906 997761005550 mannonate dehydratase; Region: uxuA; TIGR00695 997761005551 D-mannonate oxidoreductase; Provisional; Region: PRK08277 997761005552 putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935 997761005553 putative NAD(P) binding site [chemical binding]; other site 997761005554 active site 997761005555 Uncharacterized conserved protein [Function unknown]; Region: COG0327 997761005556 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 997761005557 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761005558 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005559 Helix-turn-helix domain; Region: HTH_18; pfam12833 997761005560 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005561 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 997761005562 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 997761005563 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 997761005564 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 997761005565 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761005566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005567 dimer interface [polypeptide binding]; other site 997761005568 putative PBP binding loops; other site 997761005569 ABC-ATPase subunit interface; other site 997761005570 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005572 dimer interface [polypeptide binding]; other site 997761005573 conserved gate region; other site 997761005574 putative PBP binding loops; other site 997761005575 ABC-ATPase subunit interface; other site 997761005576 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761005577 Histidine kinase; Region: His_kinase; pfam06580 997761005578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761005579 ATP binding site [chemical binding]; other site 997761005580 Mg2+ binding site [ion binding]; other site 997761005581 G-X-G motif; other site 997761005582 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005583 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005584 Response regulator receiver domain; Region: Response_reg; pfam00072 997761005585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761005586 active site 997761005587 phosphorylation site [posttranslational modification] 997761005588 intermolecular recognition site; other site 997761005589 dimerization interface [polypeptide binding]; other site 997761005590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005591 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761005592 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005593 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 997761005594 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 997761005595 inhibitor binding site; inhibition site 997761005596 catalytic Zn binding site [ion binding]; other site 997761005597 structural Zn binding site [ion binding]; other site 997761005598 NADP binding site [chemical binding]; other site 997761005599 tetramer interface [polypeptide binding]; other site 997761005600 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 997761005601 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 997761005602 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 997761005603 active site 997761005604 DNA binding site [nucleotide binding] 997761005605 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 997761005606 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 997761005607 NADH(P)-binding; Region: NAD_binding_10; pfam13460 997761005608 NAD binding site [chemical binding]; other site 997761005609 substrate binding site [chemical binding]; other site 997761005610 putative active site [active] 997761005611 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 997761005612 UbiA prenyltransferase family; Region: UbiA; pfam01040 997761005613 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761005614 Helix-turn-helix domain; Region: HTH_18; pfam12833 997761005615 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005616 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 997761005617 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 997761005618 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 997761005619 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 997761005620 NAD(P) binding site [chemical binding]; other site 997761005621 catalytic residues [active] 997761005622 malate:quinone oxidoreductase; Validated; Region: PRK05257 997761005623 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 997761005624 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761005625 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761005626 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761005627 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 997761005629 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 997761005630 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 997761005631 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 997761005632 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 997761005633 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761005634 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005635 Cupin domain; Region: Cupin_2; pfam07883 997761005636 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761005637 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005638 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 997761005639 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 997761005640 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 997761005641 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 997761005642 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 997761005643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761005644 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 997761005645 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 997761005646 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 997761005647 dimerization domain swap beta strand [polypeptide binding]; other site 997761005648 regulatory protein interface [polypeptide binding]; other site 997761005649 active site 997761005650 regulatory phosphorylation site [posttranslational modification]; other site 997761005651 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 997761005652 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 997761005653 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 997761005654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005655 dimer interface [polypeptide binding]; other site 997761005656 conserved gate region; other site 997761005657 ABC-ATPase subunit interface; other site 997761005658 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005659 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005660 dimer interface [polypeptide binding]; other site 997761005661 conserved gate region; other site 997761005662 ABC-ATPase subunit interface; other site 997761005663 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 997761005664 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 997761005665 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005666 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761005667 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761005668 dimerization interface [polypeptide binding]; other site 997761005669 Histidine kinase; Region: His_kinase; pfam06580 997761005670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761005671 ATP binding site [chemical binding]; other site 997761005672 Mg2+ binding site [ion binding]; other site 997761005673 G-X-G motif; other site 997761005674 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 997761005675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761005676 active site 997761005677 phosphorylation site [posttranslational modification] 997761005678 intermolecular recognition site; other site 997761005679 dimerization interface [polypeptide binding]; other site 997761005680 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005681 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005682 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005683 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 997761005684 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 997761005685 active site 997761005686 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 997761005687 dimerization interface [polypeptide binding]; other site 997761005688 putative active cleft [active] 997761005689 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 997761005690 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 997761005691 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 997761005692 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761005693 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761005694 active site 997761005695 phosphorylation site [posttranslational modification] 997761005696 intermolecular recognition site; other site 997761005697 dimerization interface [polypeptide binding]; other site 997761005698 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761005699 DNA binding site [nucleotide binding] 997761005700 CHASE3 domain; Region: CHASE3; cl05000 997761005701 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761005702 dimerization interface [polypeptide binding]; other site 997761005703 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761005704 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761005705 metal binding site [ion binding]; metal-binding site 997761005706 active site 997761005707 I-site; other site 997761005708 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005709 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005710 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 997761005711 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761005712 active site 997761005713 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005714 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005715 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761005716 dimerization interface [polypeptide binding]; other site 997761005717 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761005718 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761005719 dimer interface [polypeptide binding]; other site 997761005720 putative CheW interface [polypeptide binding]; other site 997761005721 Histidine kinase; Region: His_kinase; pfam06580 997761005722 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761005723 ATP binding site [chemical binding]; other site 997761005724 Mg2+ binding site [ion binding]; other site 997761005725 G-X-G motif; other site 997761005726 Response regulator receiver domain; Region: Response_reg; pfam00072 997761005727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761005728 active site 997761005729 phosphorylation site [posttranslational modification] 997761005730 intermolecular recognition site; other site 997761005731 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761005732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005733 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 997761005734 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 997761005735 Ca binding site [ion binding]; other site 997761005736 active site 997761005737 catalytic site [active] 997761005738 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 997761005739 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005740 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 997761005741 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005742 dimer interface [polypeptide binding]; other site 997761005743 conserved gate region; other site 997761005744 putative PBP binding loops; other site 997761005745 ABC-ATPase subunit interface; other site 997761005746 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005747 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005748 dimer interface [polypeptide binding]; other site 997761005749 conserved gate region; other site 997761005750 putative PBP binding loops; other site 997761005751 ABC-ATPase subunit interface; other site 997761005752 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 997761005753 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 997761005754 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 997761005755 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 997761005756 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 997761005757 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 997761005758 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 997761005759 putative metal binding site [ion binding]; other site 997761005760 Arrestin (or S-antigen), C-terminal domain; Region: Arrestin_C; pfam02752 997761005761 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 997761005762 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 997761005763 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761005764 Interdomain contacts; other site 997761005765 Cytokine receptor motif; other site 997761005766 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 997761005767 dockerin binding interface; other site 997761005768 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761005769 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761005770 dimerization interface [polypeptide binding]; other site 997761005771 Histidine kinase; Region: His_kinase; pfam06580 997761005772 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761005773 ATP binding site [chemical binding]; other site 997761005774 Mg2+ binding site [ion binding]; other site 997761005775 G-X-G motif; other site 997761005776 Response regulator receiver domain; Region: Response_reg; pfam00072 997761005777 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761005778 active site 997761005779 phosphorylation site [posttranslational modification] 997761005780 intermolecular recognition site; other site 997761005781 dimerization interface [polypeptide binding]; other site 997761005782 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005783 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761005784 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005785 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 997761005786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005787 dimer interface [polypeptide binding]; other site 997761005788 conserved gate region; other site 997761005789 putative PBP binding loops; other site 997761005790 ABC-ATPase subunit interface; other site 997761005791 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005793 dimer interface [polypeptide binding]; other site 997761005794 conserved gate region; other site 997761005795 putative PBP binding loops; other site 997761005796 ABC-ATPase subunit interface; other site 997761005797 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005798 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005799 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 997761005800 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 997761005801 active site 997761005802 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761005803 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761005804 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761005805 Spore germination protein; Region: Spore_permease; cl17796 997761005806 DinB family; Region: DinB; cl17821 997761005807 DinB superfamily; Region: DinB_2; pfam12867 997761005808 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 997761005809 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761005810 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 997761005811 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761005812 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761005813 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 997761005814 metal binding site [ion binding]; metal-binding site 997761005815 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761005816 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761005817 dimerization interface [polypeptide binding]; other site 997761005818 Histidine kinase; Region: His_kinase; pfam06580 997761005819 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761005820 ATP binding site [chemical binding]; other site 997761005821 Mg2+ binding site [ion binding]; other site 997761005822 G-X-G motif; other site 997761005823 Response regulator receiver domain; Region: Response_reg; pfam00072 997761005824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761005825 active site 997761005826 phosphorylation site [posttranslational modification] 997761005827 intermolecular recognition site; other site 997761005828 dimerization interface [polypeptide binding]; other site 997761005829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005830 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761005831 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005832 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005833 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005834 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 997761005835 putative transposase OrfB; Reviewed; Region: PHA02517 997761005836 HTH-like domain; Region: HTH_21; pfam13276 997761005837 Integrase core domain; Region: rve; pfam00665 997761005838 Integrase core domain; Region: rve_3; pfam13683 997761005839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 997761005840 Transposase; Region: HTH_Tnp_1; pfam01527 997761005841 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761005842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761005843 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761005844 dimerization interface [polypeptide binding]; other site 997761005845 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 997761005846 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 997761005847 hinge; other site 997761005848 active site 997761005849 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 997761005850 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 997761005851 Tetramer interface [polypeptide binding]; other site 997761005852 active site 997761005853 FMN-binding site [chemical binding]; other site 997761005854 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005855 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005856 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 997761005857 catalytic residues [active] 997761005858 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 997761005859 metal-binding site [ion binding] 997761005860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761005861 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761005862 putative substrate translocation pore; other site 997761005863 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761005864 MarR family; Region: MarR_2; pfam12802 997761005865 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 997761005866 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 997761005867 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 997761005868 P-loop, Walker A motif; other site 997761005869 Base recognition motif; other site 997761005870 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 997761005871 S-layer homology domain; Region: SLH; pfam00395 997761005872 amidase; Provisional; Region: PRK06828 997761005873 Amidase; Region: Amidase; pfam01425 997761005874 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761005875 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761005876 metal binding site [ion binding]; metal-binding site 997761005877 active site 997761005878 I-site; other site 997761005879 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 997761005880 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 997761005881 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 997761005882 dockerin binding interface; other site 997761005883 S-layer homology domain; Region: SLH; pfam00395 997761005884 S-layer homology domain; Region: SLH; pfam00395 997761005885 S-layer homology domain; Region: SLH; pfam00395 997761005886 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761005887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005888 dimer interface [polypeptide binding]; other site 997761005889 conserved gate region; other site 997761005890 ABC-ATPase subunit interface; other site 997761005891 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005892 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005893 dimer interface [polypeptide binding]; other site 997761005894 ABC-ATPase subunit interface; other site 997761005895 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005896 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 997761005897 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 997761005898 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 997761005899 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 997761005900 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 997761005901 Predicted membrane protein [Function unknown]; Region: COG2259 997761005902 Response regulator receiver domain; Region: Response_reg; pfam00072 997761005903 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761005904 active site 997761005905 phosphorylation site [posttranslational modification] 997761005906 intermolecular recognition site; other site 997761005907 dimerization interface [polypeptide binding]; other site 997761005908 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761005909 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005910 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 997761005911 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761005912 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005913 dimer interface [polypeptide binding]; other site 997761005914 conserved gate region; other site 997761005915 ABC-ATPase subunit interface; other site 997761005916 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005917 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005918 dimer interface [polypeptide binding]; other site 997761005919 conserved gate region; other site 997761005920 putative PBP binding loops; other site 997761005921 ABC-ATPase subunit interface; other site 997761005922 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005923 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005924 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761005925 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761005926 dimerization interface [polypeptide binding]; other site 997761005927 Histidine kinase; Region: His_kinase; pfam06580 997761005928 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761005929 ATP binding site [chemical binding]; other site 997761005930 Mg2+ binding site [ion binding]; other site 997761005931 G-X-G motif; other site 997761005932 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 997761005933 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761005934 active site 997761005935 phosphorylation site [posttranslational modification] 997761005936 intermolecular recognition site; other site 997761005937 dimerization interface [polypeptide binding]; other site 997761005938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005939 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005940 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 997761005941 catalytic core [active] 997761005942 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 997761005943 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 997761005944 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 997761005945 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 997761005946 catalytic site [active] 997761005947 Predicted transcriptional regulator [Transcription]; Region: COG2378 997761005948 HTH domain; Region: HTH_11; pfam08279 997761005949 WYL domain; Region: WYL; pfam13280 997761005950 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 997761005951 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 997761005952 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 997761005953 active site 997761005954 putative catalytic site [active] 997761005955 DNA binding site [nucleotide binding] 997761005956 putative phosphate binding site [ion binding]; other site 997761005957 metal binding site A [ion binding]; metal-binding site 997761005958 AP binding site [nucleotide binding]; other site 997761005959 metal binding site B [ion binding]; metal-binding site 997761005960 PilZ domain; Region: PilZ; pfam07238 997761005961 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761005962 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005963 dimer interface [polypeptide binding]; other site 997761005964 conserved gate region; other site 997761005965 ABC-ATPase subunit interface; other site 997761005966 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761005967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761005968 dimer interface [polypeptide binding]; other site 997761005969 conserved gate region; other site 997761005970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761005971 ABC-ATPase subunit interface; other site 997761005972 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761005973 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761005974 dimerization interface [polypeptide binding]; other site 997761005975 Histidine kinase; Region: His_kinase; pfam06580 997761005976 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761005977 ATP binding site [chemical binding]; other site 997761005978 Mg2+ binding site [ion binding]; other site 997761005979 G-X-G motif; other site 997761005980 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761005981 Response regulator receiver domain; Region: Response_reg; pfam00072 997761005982 active site 997761005983 phosphorylation site [posttranslational modification] 997761005984 intermolecular recognition site; other site 997761005985 dimerization interface [polypeptide binding]; other site 997761005986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005987 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761005988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761005989 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761005990 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761005991 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761005992 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 997761005993 NAD(P) binding site [chemical binding]; other site 997761005994 active site 997761005995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 997761005996 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 997761005997 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761005998 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761005999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006000 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006001 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 997761006002 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761006003 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761006004 dimer interface [polypeptide binding]; other site 997761006005 phosphorylation site [posttranslational modification] 997761006006 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761006007 ATP binding site [chemical binding]; other site 997761006008 Mg2+ binding site [ion binding]; other site 997761006009 G-X-G motif; other site 997761006010 Transposase; Region: DDE_Tnp_ISL3; pfam01610 997761006011 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761006012 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761006013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761006014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761006015 putative substrate translocation pore; other site 997761006016 Predicted transcriptional regulators [Transcription]; Region: COG1510 997761006017 MarR family; Region: MarR_2; cl17246 997761006018 BCCT family transporter; Region: BCCT; pfam02028 997761006019 Predicted transcriptional regulator [Transcription]; Region: COG4189 997761006020 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761006021 dimerization interface [polypeptide binding]; other site 997761006022 putative DNA binding site [nucleotide binding]; other site 997761006023 putative Zn2+ binding site [ion binding]; other site 997761006024 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 997761006025 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 997761006026 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 997761006027 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761006028 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761006029 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761006030 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761006031 dimerization interface [polypeptide binding]; other site 997761006032 Histidine kinase; Region: His_kinase; pfam06580 997761006033 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761006034 ATP binding site [chemical binding]; other site 997761006035 Mg2+ binding site [ion binding]; other site 997761006036 G-X-G motif; other site 997761006037 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006038 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761006039 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006040 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761006041 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006042 dimer interface [polypeptide binding]; other site 997761006043 conserved gate region; other site 997761006044 ABC-ATPase subunit interface; other site 997761006045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761006046 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761006047 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 997761006048 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 997761006049 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 997761006050 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 997761006051 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761006052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006053 putative PBP binding loops; other site 997761006054 ABC-ATPase subunit interface; other site 997761006055 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761006056 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006057 dimer interface [polypeptide binding]; other site 997761006058 conserved gate region; other site 997761006059 putative PBP binding loops; other site 997761006060 ABC-ATPase subunit interface; other site 997761006061 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 997761006062 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 997761006063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761006064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761006065 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 997761006066 active site 997761006067 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 997761006068 substrate binding site [chemical binding]; other site 997761006069 catalytic residues [active] 997761006070 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 997761006071 putative hydrophobic ligand binding site [chemical binding]; other site 997761006072 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761006073 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761006074 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006075 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761006076 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761006077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006078 dimer interface [polypeptide binding]; other site 997761006079 conserved gate region; other site 997761006080 putative PBP binding loops; other site 997761006081 ABC-ATPase subunit interface; other site 997761006082 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761006083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006084 dimer interface [polypeptide binding]; other site 997761006085 conserved gate region; other site 997761006086 putative PBP binding loops; other site 997761006087 ABC-ATPase subunit interface; other site 997761006088 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 997761006089 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 997761006090 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 997761006091 putative active site [active] 997761006092 putative catalytic site [active] 997761006093 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761006094 HAMP domain; Region: HAMP; pfam00672 997761006095 Histidine kinase; Region: His_kinase; pfam06580 997761006096 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761006097 ATP binding site [chemical binding]; other site 997761006098 Mg2+ binding site [ion binding]; other site 997761006099 G-X-G motif; other site 997761006100 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 997761006101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761006102 active site 997761006103 phosphorylation site [posttranslational modification] 997761006104 intermolecular recognition site; other site 997761006105 dimerization interface [polypeptide binding]; other site 997761006106 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006107 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006108 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761006109 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761006110 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761006111 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006112 dimer interface [polypeptide binding]; other site 997761006113 conserved gate region; other site 997761006114 putative PBP binding loops; other site 997761006115 ABC-ATPase subunit interface; other site 997761006116 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761006117 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761006118 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 997761006119 Histidine kinase; Region: HisKA_3; pfam07730 997761006120 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761006121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761006122 active site 997761006123 phosphorylation site [posttranslational modification] 997761006124 intermolecular recognition site; other site 997761006125 dimerization interface [polypeptide binding]; other site 997761006126 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761006127 DNA binding residues [nucleotide binding] 997761006128 dimerization interface [polypeptide binding]; other site 997761006129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761006130 putative substrate translocation pore; other site 997761006131 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761006132 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761006133 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761006134 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761006135 dimerization interface [polypeptide binding]; other site 997761006136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761006137 Coenzyme A binding pocket [chemical binding]; other site 997761006138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761006139 S-adenosylmethionine binding site [chemical binding]; other site 997761006140 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 997761006141 DNA-binding site [nucleotide binding]; DNA binding site 997761006142 RNA-binding motif; other site 997761006143 Cold-inducible protein YdjO; Region: YdjO; pfam14169 997761006144 GRAS family transcription factor; Region: GRAS; pfam03514 997761006145 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761006146 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761006147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006149 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761006150 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761006151 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761006152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006153 dimer interface [polypeptide binding]; other site 997761006154 conserved gate region; other site 997761006155 putative PBP binding loops; other site 997761006156 ABC-ATPase subunit interface; other site 997761006157 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761006158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006159 dimer interface [polypeptide binding]; other site 997761006160 conserved gate region; other site 997761006161 putative PBP binding loops; other site 997761006162 ABC-ATPase subunit interface; other site 997761006163 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 997761006164 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 997761006165 Predicted transcriptional regulator [Transcription]; Region: COG2378 997761006166 HTH domain; Region: HTH_11; pfam08279 997761006167 WYL domain; Region: WYL; pfam13280 997761006168 TfoX C-terminal domain; Region: TfoX_C; pfam04994 997761006169 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761006170 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 997761006171 active site 997761006172 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 997761006173 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761006174 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 997761006175 dimer interface [polypeptide binding]; other site 997761006176 putative metal binding site [ion binding]; other site 997761006177 LysE type translocator; Region: LysE; pfam01810 997761006178 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 997761006179 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761006180 Coenzyme A binding pocket [chemical binding]; other site 997761006181 AAA domain; Region: AAA_18; pfam13238 997761006182 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 997761006183 active site 997761006184 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 997761006185 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 997761006186 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761006187 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761006188 ABC transporter; Region: ABC_tran_2; pfam12848 997761006189 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761006190 EamA-like transporter family; Region: EamA; pfam00892 997761006191 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 997761006192 EamA-like transporter family; Region: EamA; pfam00892 997761006193 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 997761006194 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 997761006195 DNA binding residues [nucleotide binding] 997761006196 putative dimer interface [polypeptide binding]; other site 997761006197 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 997761006198 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 997761006199 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761006200 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761006201 active site 997761006202 catalytic tetrad [active] 997761006203 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 997761006204 active site 997761006205 catalytic triad [active] 997761006206 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 997761006207 Cytochrome P450; Region: p450; pfam00067 997761006208 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761006209 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761006210 active site 997761006211 phosphorylation site [posttranslational modification] 997761006212 intermolecular recognition site; other site 997761006213 dimerization interface [polypeptide binding]; other site 997761006214 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761006215 DNA binding site [nucleotide binding] 997761006216 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761006217 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761006218 dimer interface [polypeptide binding]; other site 997761006219 phosphorylation site [posttranslational modification] 997761006220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761006221 ATP binding site [chemical binding]; other site 997761006222 Mg2+ binding site [ion binding]; other site 997761006223 G-X-G motif; other site 997761006224 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 997761006225 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 997761006226 Walker A/P-loop; other site 997761006227 ATP binding site [chemical binding]; other site 997761006228 Q-loop/lid; other site 997761006229 ABC transporter signature motif; other site 997761006230 Walker B; other site 997761006231 D-loop; other site 997761006232 H-loop/switch region; other site 997761006233 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 997761006234 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 997761006235 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 997761006236 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 997761006237 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761006238 dimerization interface [polypeptide binding]; other site 997761006239 putative DNA binding site [nucleotide binding]; other site 997761006240 putative Zn2+ binding site [ion binding]; other site 997761006241 EamA-like transporter family; Region: EamA; pfam00892 997761006242 EamA-like transporter family; Region: EamA; pfam00892 997761006243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761006244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761006245 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761006246 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761006247 putative substrate translocation pore; other site 997761006248 Predicted transcriptional regulators [Transcription]; Region: COG1695 997761006249 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 997761006250 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 997761006251 substrate binding site [chemical binding]; other site 997761006252 active site 997761006253 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 997761006254 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318 997761006255 DinB superfamily; Region: DinB_2; pfam12867 997761006256 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 997761006257 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761006258 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 997761006259 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 997761006260 classical (c) SDRs; Region: SDR_c; cd05233 997761006261 NAD(P) binding site [chemical binding]; other site 997761006262 active site 997761006263 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 997761006264 Predicted transcriptional regulators [Transcription]; Region: COG1695 997761006265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761006266 salt bridge; other site 997761006267 non-specific DNA binding site [nucleotide binding]; other site 997761006268 sequence-specific DNA binding site [nucleotide binding]; other site 997761006269 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 997761006270 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 997761006271 NAD(P) binding site [chemical binding]; other site 997761006272 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 997761006273 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 997761006274 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 997761006275 homodimer interface [polypeptide binding]; other site 997761006276 NADP binding site [chemical binding]; other site 997761006277 substrate binding site [chemical binding]; other site 997761006278 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 997761006279 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761006280 Coenzyme A binding pocket [chemical binding]; other site 997761006281 oligoendopeptidase F; Region: pepF; TIGR00181 997761006282 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 997761006283 active site 997761006284 Zn binding site [ion binding]; other site 997761006285 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 997761006286 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 997761006287 short chain dehydrogenase; Provisional; Region: PRK07677 997761006288 Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369 997761006289 NAD(P) binding site [chemical binding]; other site 997761006290 substrate binding site [chemical binding]; other site 997761006291 homotetramer interface [polypeptide binding]; other site 997761006292 active site 997761006293 homodimer interface [polypeptide binding]; other site 997761006294 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 997761006295 active site 997761006296 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761006297 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 997761006298 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 997761006299 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761006300 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 997761006301 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761006302 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 997761006303 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 997761006304 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761006305 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761006306 Interdomain contacts; other site 997761006307 Cytokine receptor motif; other site 997761006308 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 997761006309 dockerin binding interface; other site 997761006310 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761006311 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761006312 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761006313 Response regulator receiver domain; Region: Response_reg; pfam00072 997761006314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761006315 active site 997761006316 phosphorylation site [posttranslational modification] 997761006317 intermolecular recognition site; other site 997761006318 dimerization interface [polypeptide binding]; other site 997761006319 LytTr DNA-binding domain; Region: LytTR; pfam04397 997761006320 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761006321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761006322 ATP binding site [chemical binding]; other site 997761006323 Mg2+ binding site [ion binding]; other site 997761006324 G-X-G motif; other site 997761006325 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 997761006326 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 997761006327 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 997761006328 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 997761006329 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 997761006330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761006331 DNA-binding site [nucleotide binding]; DNA binding site 997761006332 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761006333 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761006334 homodimer interface [polypeptide binding]; other site 997761006335 catalytic residue [active] 997761006336 EamA-like transporter family; Region: EamA; pfam00892 997761006337 EamA-like transporter family; Region: EamA; pfam00892 997761006338 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 997761006339 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761006340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006341 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761006342 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761006344 C factor cell-cell signaling protein; Provisional; Region: PRK09009 997761006345 NAD(P) binding site [chemical binding]; other site 997761006346 active site 997761006347 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 997761006348 conserved cys residue [active] 997761006349 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761006350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006351 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761006352 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 997761006353 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 997761006354 tellurite resistance protein TehB; Provisional; Region: PRK11207 997761006355 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761006356 S-adenosylmethionine binding site [chemical binding]; other site 997761006357 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627 997761006358 Methyltransferase domain; Region: Methyltransf_23; pfam13489 997761006359 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761006360 Coenzyme A binding pocket [chemical binding]; other site 997761006361 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 997761006362 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761006363 NAD(P) binding site [chemical binding]; other site 997761006364 active site 997761006365 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 997761006366 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 997761006367 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 997761006368 Multicopper oxidase; Region: Cu-oxidase; pfam00394 997761006369 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 997761006370 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761006371 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761006372 S-layer homology domain; Region: SLH; pfam00395 997761006373 S-layer homology domain; Region: SLH; pfam00395 997761006374 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761006375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761006376 active site 997761006377 phosphorylation site [posttranslational modification] 997761006378 intermolecular recognition site; other site 997761006379 dimerization interface [polypeptide binding]; other site 997761006380 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761006381 DNA binding site [nucleotide binding] 997761006382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761006383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761006384 dimerization interface [polypeptide binding]; other site 997761006385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761006386 dimer interface [polypeptide binding]; other site 997761006387 phosphorylation site [posttranslational modification] 997761006388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761006389 ATP binding site [chemical binding]; other site 997761006390 Mg2+ binding site [ion binding]; other site 997761006391 G-X-G motif; other site 997761006392 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 997761006393 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 997761006394 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 997761006395 Penicillinase repressor; Region: Pencillinase_R; pfam03965 997761006396 acetoacetyl-CoA reductase; Provisional; Region: PRK12824 997761006397 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 997761006398 NADP binding site [chemical binding]; other site 997761006399 substrate binding site [chemical binding]; other site 997761006400 active site 997761006401 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 997761006402 homotrimer interaction site [polypeptide binding]; other site 997761006403 putative active site [active] 997761006404 LysE type translocator; Region: LysE; cl00565 997761006405 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761006406 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006407 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761006408 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 997761006409 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761006410 NAD(P) binding site [chemical binding]; other site 997761006411 active site 997761006412 EamA-like transporter family; Region: EamA; pfam00892 997761006413 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 997761006414 EamA-like transporter family; Region: EamA; cl17759 997761006415 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 997761006416 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761006417 putative homodimer interface [polypeptide binding]; other site 997761006418 Sm and related proteins; Region: Sm_like; cl00259 997761006419 heptamer interface [polypeptide binding]; other site 997761006420 Sm1 motif; other site 997761006421 hexamer interface [polypeptide binding]; other site 997761006422 RNA binding site [nucleotide binding]; other site 997761006423 Sm2 motif; other site 997761006424 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 997761006425 DHH family; Region: DHH; pfam01368 997761006426 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761006427 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761006428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761006429 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761006430 putative substrate translocation pore; other site 997761006431 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 997761006432 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761006433 ATP binding site [chemical binding]; other site 997761006434 Mg2+ binding site [ion binding]; other site 997761006435 G-X-G motif; other site 997761006436 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 997761006437 Citrate transporter; Region: CitMHS; pfam03600 997761006438 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 997761006439 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 997761006440 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 997761006441 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 997761006442 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 997761006443 active site 997761006444 substrate-binding site [chemical binding]; other site 997761006445 metal-binding site [ion binding] 997761006446 ATP binding site [chemical binding]; other site 997761006447 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 997761006448 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761006449 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761006450 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761006451 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761006452 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761006453 DNA binding site [nucleotide binding] 997761006454 domain linker motif; other site 997761006455 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 997761006456 dimerization interface [polypeptide binding]; other site 997761006457 ligand binding site [chemical binding]; other site 997761006458 High-affinity nickel-transport protein; Region: NicO; cl00964 997761006459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761006460 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761006461 dimerization interface [polypeptide binding]; other site 997761006462 Histidine kinase; Region: His_kinase; pfam06580 997761006463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761006464 ATP binding site [chemical binding]; other site 997761006465 Mg2+ binding site [ion binding]; other site 997761006466 G-X-G motif; other site 997761006467 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761006468 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761006469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006470 dimer interface [polypeptide binding]; other site 997761006471 conserved gate region; other site 997761006472 putative PBP binding loops; other site 997761006473 ABC-ATPase subunit interface; other site 997761006474 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761006475 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006476 dimer interface [polypeptide binding]; other site 997761006477 conserved gate region; other site 997761006478 putative PBP binding loops; other site 997761006479 ABC-ATPase subunit interface; other site 997761006480 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 997761006481 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 997761006482 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 997761006483 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761006484 PAS domain; Region: PAS_9; pfam13426 997761006485 putative active site [active] 997761006486 heme pocket [chemical binding]; other site 997761006487 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761006488 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761006489 metal binding site [ion binding]; metal-binding site 997761006490 active site 997761006491 I-site; other site 997761006492 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 997761006493 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 997761006494 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 997761006495 PYR/PP interface [polypeptide binding]; other site 997761006496 dimer interface [polypeptide binding]; other site 997761006497 TPP binding site [chemical binding]; other site 997761006498 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 997761006499 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 997761006500 TPP-binding site [chemical binding]; other site 997761006501 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 997761006502 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 997761006503 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 997761006504 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 997761006505 PYR/PP interface [polypeptide binding]; other site 997761006506 dimer interface [polypeptide binding]; other site 997761006507 TPP binding site [chemical binding]; other site 997761006508 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 997761006509 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 997761006510 TPP-binding site [chemical binding]; other site 997761006511 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 997761006512 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761006513 putative active site [active] 997761006514 heme pocket [chemical binding]; other site 997761006515 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761006516 dimer interface [polypeptide binding]; other site 997761006517 phosphorylation site [posttranslational modification] 997761006518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761006519 ATP binding site [chemical binding]; other site 997761006520 Mg2+ binding site [ion binding]; other site 997761006521 G-X-G motif; other site 997761006522 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 997761006523 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 997761006524 Walker A/P-loop; other site 997761006525 ATP binding site [chemical binding]; other site 997761006526 Q-loop/lid; other site 997761006527 ABC transporter signature motif; other site 997761006528 Walker B; other site 997761006529 D-loop; other site 997761006530 H-loop/switch region; other site 997761006531 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 997761006532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006533 dimer interface [polypeptide binding]; other site 997761006534 conserved gate region; other site 997761006535 putative PBP binding loops; other site 997761006536 ABC-ATPase subunit interface; other site 997761006537 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 997761006538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006539 dimer interface [polypeptide binding]; other site 997761006540 conserved gate region; other site 997761006541 putative PBP binding loops; other site 997761006542 ABC-ATPase subunit interface; other site 997761006543 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 997761006544 NMT1/THI5 like; Region: NMT1; pfam09084 997761006545 aminotransferase; Validated; Region: PRK07678 997761006546 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 997761006547 inhibitor-cofactor binding pocket; inhibition site 997761006548 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761006549 catalytic residue [active] 997761006550 allantoate amidohydrolase; Reviewed; Region: PRK09290 997761006551 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 997761006552 active site 997761006553 metal binding site [ion binding]; metal-binding site 997761006554 dimer interface [polypeptide binding]; other site 997761006555 mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases); Region: ML_beta-AS_like; cd07568 997761006556 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 997761006557 putative active site [active] 997761006558 catalytic triad [active] 997761006559 multimer interface [polypeptide binding]; other site 997761006560 dimer interface [polypeptide binding]; other site 997761006561 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 997761006562 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 997761006563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 997761006564 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 997761006565 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 997761006566 homodimer interface [polypeptide binding]; other site 997761006567 active site 997761006568 FMN binding site [chemical binding]; other site 997761006569 substrate binding site [chemical binding]; other site 997761006570 4Fe-4S binding domain; Region: Fer4; pfam00037 997761006571 phenylhydantoinase; Validated; Region: PRK08323 997761006572 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 997761006573 tetramer interface [polypeptide binding]; other site 997761006574 active site 997761006575 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 997761006576 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 997761006577 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 997761006578 Predicted transcriptional regulators [Transcription]; Region: COG1695 997761006579 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761006580 putative DNA binding site [nucleotide binding]; other site 997761006581 putative Zn2+ binding site [ion binding]; other site 997761006582 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 997761006583 substrate binding site [chemical binding]; other site 997761006584 active site 997761006585 Methyltransferase domain; Region: Methyltransf_23; pfam13489 997761006586 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761006587 S-adenosylmethionine binding site [chemical binding]; other site 997761006588 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 997761006589 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 997761006590 DNA binding residues [nucleotide binding] 997761006591 Methyltransferase domain; Region: Methyltransf_23; pfam13489 997761006592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761006593 S-adenosylmethionine binding site [chemical binding]; other site 997761006594 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761006595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006596 dimer interface [polypeptide binding]; other site 997761006597 conserved gate region; other site 997761006598 putative PBP binding loops; other site 997761006599 ABC-ATPase subunit interface; other site 997761006600 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761006601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006602 dimer interface [polypeptide binding]; other site 997761006603 conserved gate region; other site 997761006604 putative PBP binding loops; other site 997761006605 ABC-ATPase subunit interface; other site 997761006606 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761006607 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761006608 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761006609 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761006610 dimerization interface [polypeptide binding]; other site 997761006611 Histidine kinase; Region: His_kinase; pfam06580 997761006612 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761006613 ATP binding site [chemical binding]; other site 997761006614 Mg2+ binding site [ion binding]; other site 997761006615 G-X-G motif; other site 997761006616 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761006617 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761006618 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761006619 dimerization interface [polypeptide binding]; other site 997761006620 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 997761006621 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 997761006622 homodimer interface [polypeptide binding]; other site 997761006623 substrate-cofactor binding pocket; other site 997761006624 catalytic residue [active] 997761006625 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761006626 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 997761006627 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 997761006628 homodimer interface [polypeptide binding]; other site 997761006629 substrate-cofactor binding pocket; other site 997761006630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761006631 catalytic residue [active] 997761006632 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 997761006633 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 997761006634 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 997761006635 Walker A/P-loop; other site 997761006636 ATP binding site [chemical binding]; other site 997761006637 Q-loop/lid; other site 997761006638 ABC transporter signature motif; other site 997761006639 Walker B; other site 997761006640 D-loop; other site 997761006641 H-loop/switch region; other site 997761006642 Predicted transcriptional regulators [Transcription]; Region: COG1725 997761006643 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761006644 DNA-binding site [nucleotide binding]; DNA binding site 997761006645 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 997761006646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 997761006647 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 997761006648 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 997761006649 dimanganese center [ion binding]; other site 997761006650 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 997761006651 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 997761006652 active site 997761006653 Pirin-related protein [General function prediction only]; Region: COG1741 997761006654 Pirin; Region: Pirin; pfam02678 997761006655 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 997761006656 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 997761006657 aspartate racemase; Region: asp_race; TIGR00035 997761006658 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761006659 Spore germination protein; Region: Spore_permease; cl17796 997761006660 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761006661 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761006662 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761006663 dimerization interface [polypeptide binding]; other site 997761006664 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761006665 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761006666 dimer interface [polypeptide binding]; other site 997761006667 putative CheW interface [polypeptide binding]; other site 997761006668 L-arabinose isomerase; Provisional; Region: PRK02929 997761006669 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 997761006670 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 997761006671 trimer interface [polypeptide binding]; other site 997761006672 putative substrate binding site [chemical binding]; other site 997761006673 putative metal binding site [ion binding]; other site 997761006674 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 997761006675 active site 997761006676 catalytic residues [active] 997761006677 Domain of unknown function (DUF4385); Region: DUF4385; pfam14328 997761006678 Domain of unknown function (DUF4182); Region: DUF4182; pfam13790 997761006679 Cache domain; Region: Cache_1; pfam02743 997761006680 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761006681 dimerization interface [polypeptide binding]; other site 997761006682 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761006683 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761006684 dimer interface [polypeptide binding]; other site 997761006685 putative CheW interface [polypeptide binding]; other site 997761006686 Clp protease; Region: CLP_protease; pfam00574 997761006687 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 997761006688 oligomer interface [polypeptide binding]; other site 997761006689 active site residues [active] 997761006690 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761006691 putative DNA binding site [nucleotide binding]; other site 997761006692 putative Zn2+ binding site [ion binding]; other site 997761006693 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 997761006694 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 997761006695 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761006696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761006697 active site 997761006698 phosphorylation site [posttranslational modification] 997761006699 intermolecular recognition site; other site 997761006700 dimerization interface [polypeptide binding]; other site 997761006701 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761006702 DNA binding site [nucleotide binding] 997761006703 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761006704 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761006705 dimerization interface [polypeptide binding]; other site 997761006706 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761006707 dimer interface [polypeptide binding]; other site 997761006708 phosphorylation site [posttranslational modification] 997761006709 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761006710 ATP binding site [chemical binding]; other site 997761006711 Mg2+ binding site [ion binding]; other site 997761006712 G-X-G motif; other site 997761006713 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 997761006714 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 997761006715 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761006716 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761006717 Initiator Replication protein; Region: Rep_3; pfam01051 997761006718 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761006719 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761006720 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 997761006721 beta-galactosidase; Region: BGL; TIGR03356 997761006722 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761006723 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761006724 DNA binding site [nucleotide binding] 997761006725 domain linker motif; other site 997761006726 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 997761006727 putative dimerization interface [polypeptide binding]; other site 997761006728 putative ligand binding site [chemical binding]; other site 997761006729 Alginate lyase; Region: Alginate_lyase; pfam05426 997761006730 Bacterial SH3 domain; Region: SH3_3; pfam08239 997761006731 Bacterial SH3 domain; Region: SH3_3; pfam08239 997761006732 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 997761006733 NlpC/P60 family; Region: NLPC_P60; pfam00877 997761006734 hypothetical protein; Provisional; Region: PRK02237 997761006735 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 997761006736 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 997761006737 putative ligand binding site [chemical binding]; other site 997761006738 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 997761006739 HAMP domain; Region: HAMP; pfam00672 997761006740 dimerization interface [polypeptide binding]; other site 997761006741 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761006742 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761006743 dimer interface [polypeptide binding]; other site 997761006744 putative CheW interface [polypeptide binding]; other site 997761006745 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 997761006746 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 997761006747 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 997761006748 PAS domain S-box; Region: sensory_box; TIGR00229 997761006749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761006750 putative active site [active] 997761006751 heme pocket [chemical binding]; other site 997761006752 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761006753 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761006754 metal binding site [ion binding]; metal-binding site 997761006755 active site 997761006756 I-site; other site 997761006757 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 997761006758 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761006759 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761006760 DNA binding site [nucleotide binding] 997761006761 domain linker motif; other site 997761006762 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 997761006763 dimerization interface [polypeptide binding]; other site 997761006764 ligand binding site [chemical binding]; other site 997761006765 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761006766 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761006767 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761006768 Response regulator receiver domain; Region: Response_reg; pfam00072 997761006769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761006770 active site 997761006771 phosphorylation site [posttranslational modification] 997761006772 intermolecular recognition site; other site 997761006773 dimerization interface [polypeptide binding]; other site 997761006774 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 997761006775 metal-dependent hydrolase; Provisional; Region: PRK00685 997761006776 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761006777 Coenzyme A binding pocket [chemical binding]; other site 997761006778 PAS domain S-box; Region: sensory_box; TIGR00229 997761006779 PAS domain; Region: PAS; smart00091 997761006780 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761006781 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761006782 metal binding site [ion binding]; metal-binding site 997761006783 active site 997761006784 I-site; other site 997761006785 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 997761006786 Sulfatase; Region: Sulfatase; pfam00884 997761006787 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 997761006788 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 997761006789 GIY-YIG motif/motif A; other site 997761006790 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 997761006791 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 997761006792 phosphopeptide binding site; other site 997761006793 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761006794 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 997761006795 DNA binding site [nucleotide binding] 997761006796 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 997761006797 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 997761006798 hinge; other site 997761006799 active site 997761006800 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 997761006801 active site 997761006802 multimer interface [polypeptide binding]; other site 997761006803 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761006804 non-specific DNA binding site [nucleotide binding]; other site 997761006805 salt bridge; other site 997761006806 sequence-specific DNA binding site [nucleotide binding]; other site 997761006807 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 997761006808 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 997761006809 Transposase; Region: DEDD_Tnp_IS110; pfam01548 997761006810 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761006811 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006812 Helix-turn-helix domain; Region: HTH_18; pfam12833 997761006813 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006814 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761006815 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761006816 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761006817 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 997761006818 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761006819 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 997761006820 putative dimerization interface [polypeptide binding]; other site 997761006821 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 997761006822 fructuronate transporter; Provisional; Region: PRK10034; cl15264 997761006823 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 997761006824 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761006825 NAD(P) binding site [chemical binding]; other site 997761006826 active site 997761006827 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 997761006828 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 997761006829 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 997761006830 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 997761006831 putative active site [active] 997761006832 putative NTP binding site [chemical binding]; other site 997761006833 putative nucleic acid binding site [nucleotide binding]; other site 997761006834 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 997761006835 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 997761006836 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 997761006837 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 997761006838 Mg++ binding site [ion binding]; other site 997761006839 putative catalytic motif [active] 997761006840 substrate binding site [chemical binding]; other site 997761006841 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761006842 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761006843 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006844 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761006845 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 997761006846 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 997761006847 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 997761006848 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761006849 dimer interface [polypeptide binding]; other site 997761006850 conserved gate region; other site 997761006851 ABC-ATPase subunit interface; other site 997761006852 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 997761006853 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 997761006854 Walker A/P-loop; other site 997761006855 ATP binding site [chemical binding]; other site 997761006856 Q-loop/lid; other site 997761006857 ABC transporter signature motif; other site 997761006858 Walker B; other site 997761006859 D-loop; other site 997761006860 H-loop/switch region; other site 997761006861 selenophosphate synthetase; Provisional; Region: PRK00943 997761006862 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 997761006863 dimerization interface [polypeptide binding]; other site 997761006864 putative ATP binding site [chemical binding]; other site 997761006865 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 997761006866 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 997761006867 active site residue [active] 997761006868 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761006869 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761006870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 997761006871 short chain dehydrogenase; Provisional; Region: PRK06701 997761006872 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 997761006873 NAD binding site [chemical binding]; other site 997761006874 metal binding site [ion binding]; metal-binding site 997761006875 active site 997761006876 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 997761006877 HlyD family secretion protein; Region: HlyD_3; pfam13437 997761006878 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 997761006879 Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999 997761006880 HlyD family secretion protein; Region: HlyD_3; pfam13437 997761006881 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 997761006882 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 997761006883 Walker A/P-loop; other site 997761006884 ATP binding site [chemical binding]; other site 997761006885 Q-loop/lid; other site 997761006886 ABC transporter signature motif; other site 997761006887 Walker B; other site 997761006888 D-loop; other site 997761006889 H-loop/switch region; other site 997761006890 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 997761006891 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 997761006892 FtsX-like permease family; Region: FtsX; pfam02687 997761006893 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 997761006894 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 997761006895 Chromate transporter; Region: Chromate_transp; pfam02417 997761006896 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761006897 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761006898 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 997761006899 zinc binding site [ion binding]; other site 997761006900 putative ligand binding site [chemical binding]; other site 997761006901 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761006902 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 997761006903 TM-ABC transporter signature motif; other site 997761006904 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 997761006905 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761006906 Walker A/P-loop; other site 997761006907 ATP binding site [chemical binding]; other site 997761006908 Q-loop/lid; other site 997761006909 ABC transporter signature motif; other site 997761006910 Walker B; other site 997761006911 D-loop; other site 997761006912 H-loop/switch region; other site 997761006913 Protein of unknown function (DUF3889); Region: DUF3889; pfam13028 997761006914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761006915 dimerization interface [polypeptide binding]; other site 997761006916 putative DNA binding site [nucleotide binding]; other site 997761006917 putative Zn2+ binding site [ion binding]; other site 997761006918 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 997761006919 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 997761006920 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 997761006921 active site 997761006922 Protein of unknown function (DUF962); Region: DUF962; pfam06127 997761006923 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 997761006924 rod shape-determining protein MreB; Provisional; Region: PRK13927 997761006925 MreB and similar proteins; Region: MreB_like; cd10225 997761006926 nucleotide binding site [chemical binding]; other site 997761006927 Mg binding site [ion binding]; other site 997761006928 putative protofilament interaction site [polypeptide binding]; other site 997761006929 RodZ interaction site [polypeptide binding]; other site 997761006930 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761006931 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761006932 active site 997761006933 phosphorylation site [posttranslational modification] 997761006934 intermolecular recognition site; other site 997761006935 dimerization interface [polypeptide binding]; other site 997761006936 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761006937 DNA binding site [nucleotide binding] 997761006938 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 997761006939 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 997761006940 active site 997761006941 HIGH motif; other site 997761006942 KMSKS motif; other site 997761006943 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 997761006944 tRNA binding surface [nucleotide binding]; other site 997761006945 anticodon binding site; other site 997761006946 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 997761006947 dimer interface [polypeptide binding]; other site 997761006948 putative tRNA-binding site [nucleotide binding]; other site 997761006949 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761006950 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761006951 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761006952 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 997761006953 glycogen binding site [chemical binding]; other site 997761006954 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 997761006955 Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313 997761006956 active site 997761006957 catalytic site [active] 997761006958 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 997761006959 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 997761006960 metal binding site [ion binding]; metal-binding site 997761006961 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 997761006962 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 997761006963 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 997761006964 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761006965 ABC-ATPase subunit interface; other site 997761006966 dimer interface [polypeptide binding]; other site 997761006967 putative PBP binding regions; other site 997761006968 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 997761006969 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 997761006970 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 997761006971 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761006972 FeS/SAM binding site; other site 997761006973 manganese transport transcriptional regulator; Provisional; Region: PRK03902 997761006974 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 997761006975 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 997761006976 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 997761006977 active site 997761006978 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 997761006979 nucleophile elbow; other site 997761006980 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 997761006981 Conserved membrane protein YqhR; Region: YqhR; pfam11085 997761006982 Dehydroquinase class II; Region: DHquinase_II; pfam01220 997761006983 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 997761006984 trimer interface [polypeptide binding]; other site 997761006985 active site 997761006986 dimer interface [polypeptide binding]; other site 997761006987 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 997761006988 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 997761006989 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 997761006990 active site 997761006991 elongation factor P; Validated; Region: PRK00529 997761006992 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 997761006993 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 997761006994 RNA binding site [nucleotide binding]; other site 997761006995 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 997761006996 RNA binding site [nucleotide binding]; other site 997761006997 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 997761006998 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761006999 DNA-binding site [nucleotide binding]; DNA binding site 997761007000 DRTGG domain; Region: DRTGG; pfam07085 997761007001 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 997761007002 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 997761007003 active site 2 [active] 997761007004 active site 1 [active] 997761007005 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 997761007006 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 997761007007 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 997761007008 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 997761007009 Protein of unknown function (DUF441); Region: DUF441; pfam04284 997761007010 Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045 997761007011 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 997761007012 (2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679 997761007013 Protein of unknown function (DUF2619); Region: DUF2619; pfam10942 997761007014 Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022 997761007015 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 997761007016 stage III sporulation protein AD; Region: spore_III_AD; TIGR02849 997761007017 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 997761007018 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 997761007019 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 997761007020 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 997761007021 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 997761007022 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 997761007023 carboxyltransferase (CT) interaction site; other site 997761007024 biotinylation site [posttranslational modification]; other site 997761007025 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 997761007026 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 997761007027 ATP-grasp domain; Region: ATP-grasp_4; cl17255 997761007028 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 997761007029 Asp23 family; Region: Asp23; pfam03780 997761007030 Asp23 family; Region: Asp23; pfam03780 997761007031 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 997761007032 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 997761007033 putative RNA binding site [nucleotide binding]; other site 997761007034 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 997761007035 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 997761007036 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 997761007037 homodimer interface [polypeptide binding]; other site 997761007038 NADP binding site [chemical binding]; other site 997761007039 substrate binding site [chemical binding]; other site 997761007040 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 997761007041 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 997761007042 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 997761007043 substrate binding pocket [chemical binding]; other site 997761007044 chain length determination region; other site 997761007045 substrate-Mg2+ binding site; other site 997761007046 catalytic residues [active] 997761007047 aspartate-rich region 1; other site 997761007048 active site lid residues [active] 997761007049 aspartate-rich region 2; other site 997761007050 arginine repressor; Provisional; Region: PRK04280 997761007051 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 997761007052 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 997761007053 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 997761007054 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 997761007055 Walker A/P-loop; other site 997761007056 ATP binding site [chemical binding]; other site 997761007057 Q-loop/lid; other site 997761007058 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 997761007059 Q-loop/lid; other site 997761007060 ABC transporter signature motif; other site 997761007061 Walker B; other site 997761007062 D-loop; other site 997761007063 H-loop/switch region; other site 997761007064 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 997761007065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761007066 active site 997761007067 phosphorylation site [posttranslational modification] 997761007068 intermolecular recognition site; other site 997761007069 dimerization interface [polypeptide binding]; other site 997761007070 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 997761007071 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 997761007072 Protein of unknown function (DUF2627); Region: DUF2627; pfam11118 997761007073 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 997761007074 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 997761007075 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 997761007076 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 997761007077 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 997761007078 tetramer interface [polypeptide binding]; other site 997761007079 TPP-binding site [chemical binding]; other site 997761007080 heterodimer interface [polypeptide binding]; other site 997761007081 phosphorylation loop region [posttranslational modification] 997761007082 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 997761007083 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 997761007084 alpha subunit interface [polypeptide binding]; other site 997761007085 TPP binding site [chemical binding]; other site 997761007086 heterodimer interface [polypeptide binding]; other site 997761007087 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 997761007088 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 997761007089 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 997761007090 E3 interaction surface; other site 997761007091 lipoyl attachment site [posttranslational modification]; other site 997761007092 e3 binding domain; Region: E3_binding; pfam02817 997761007093 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 997761007094 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 997761007095 peptidase T-like protein; Region: PepT-like; TIGR01883 997761007096 metal binding site [ion binding]; metal-binding site 997761007097 putative dimer interface [polypeptide binding]; other site 997761007098 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 997761007099 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 997761007100 dimer interface [polypeptide binding]; other site 997761007101 ADP-ribose binding site [chemical binding]; other site 997761007102 active site 997761007103 nudix motif; other site 997761007104 metal binding site [ion binding]; metal-binding site 997761007105 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 997761007106 PHP-associated; Region: PHP_C; pfam13263 997761007107 Integral membrane protein DUF95; Region: DUF95; cl00572 997761007108 ferric uptake regulator; Provisional; Region: fur; PRK09462 997761007109 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 997761007110 metal binding site 2 [ion binding]; metal-binding site 997761007111 putative DNA binding helix; other site 997761007112 metal binding site 1 [ion binding]; metal-binding site 997761007113 dimer interface [polypeptide binding]; other site 997761007114 structural Zn2+ binding site [ion binding]; other site 997761007115 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 997761007116 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 997761007117 hexamer interface [polypeptide binding]; other site 997761007118 ligand binding site [chemical binding]; other site 997761007119 putative active site [active] 997761007120 NAD(P) binding site [chemical binding]; other site 997761007121 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 997761007122 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 997761007123 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 997761007124 active site 997761007125 Int/Topo IB signature motif; other site 997761007126 purine nucleoside phosphorylase; Provisional; Region: PRK08202 997761007127 purine nucleoside phosphorylase; Provisional; Region: PRK08202 997761007128 flagellar operon protein TIGR03826; Region: YvyF 997761007129 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 997761007130 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 997761007131 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 997761007132 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 997761007133 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 997761007134 anti sigma factor interaction site; other site 997761007135 regulatory phosphorylation site [posttranslational modification]; other site 997761007136 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 997761007137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761007138 ATP binding site [chemical binding]; other site 997761007139 Mg2+ binding site [ion binding]; other site 997761007140 G-X-G motif; other site 997761007141 sporulation sigma factor SigF; Validated; Region: PRK05572 997761007142 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761007143 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 997761007144 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761007145 DNA binding residues [nucleotide binding] 997761007146 Domain of unknown function (DUF378); Region: DUF378; pfam04070 997761007147 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 997761007148 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 997761007149 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761007150 diaminopimelate decarboxylase; Region: lysA; TIGR01048 997761007151 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 997761007152 active site 997761007153 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 997761007154 substrate binding site [chemical binding]; other site 997761007155 catalytic residues [active] 997761007156 dimer interface [polypeptide binding]; other site 997761007157 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 997761007158 active site 997761007159 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 997761007160 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 997761007161 catalytic motif [active] 997761007162 Zn binding site [ion binding]; other site 997761007163 RibD C-terminal domain; Region: RibD_C; cl17279 997761007164 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 997761007165 Lumazine binding domain; Region: Lum_binding; pfam00677 997761007166 Lumazine binding domain; Region: Lum_binding; pfam00677 997761007167 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 997761007168 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 997761007169 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 997761007170 dimerization interface [polypeptide binding]; other site 997761007171 active site 997761007172 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 997761007173 homopentamer interface [polypeptide binding]; other site 997761007174 active site 997761007175 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 997761007176 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 997761007177 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 997761007178 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 997761007179 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 997761007180 PAS domain S-box; Region: sensory_box; TIGR00229 997761007181 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761007182 putative active site [active] 997761007183 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761007184 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761007185 metal binding site [ion binding]; metal-binding site 997761007186 active site 997761007187 I-site; other site 997761007188 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 997761007189 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 997761007190 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 997761007191 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 997761007192 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 997761007193 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 997761007194 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 997761007195 RNA binding surface [nucleotide binding]; other site 997761007196 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 997761007197 active site 997761007198 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 997761007199 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 997761007200 catalytic residues [active] 997761007201 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 997761007202 ResB-like family; Region: ResB; pfam05140 997761007203 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 997761007204 cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144 997761007205 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761007206 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761007207 active site 997761007208 phosphorylation site [posttranslational modification] 997761007209 intermolecular recognition site; other site 997761007210 dimerization interface [polypeptide binding]; other site 997761007211 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761007212 DNA binding site [nucleotide binding] 997761007213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761007214 dimerization interface [polypeptide binding]; other site 997761007215 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 997761007216 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761007217 dimer interface [polypeptide binding]; other site 997761007218 phosphorylation site [posttranslational modification] 997761007219 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761007220 ATP binding site [chemical binding]; other site 997761007221 Mg2+ binding site [ion binding]; other site 997761007222 G-X-G motif; other site 997761007223 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 997761007224 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 997761007225 ligand binding site [chemical binding]; other site 997761007226 NAD binding site [chemical binding]; other site 997761007227 dimerization interface [polypeptide binding]; other site 997761007228 catalytic site [active] 997761007229 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 997761007230 putative L-serine binding site [chemical binding]; other site 997761007231 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 997761007232 active site residue [active] 997761007233 CAAX protease self-immunity; Region: Abi; pfam02517 997761007234 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 997761007235 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 997761007236 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 997761007237 active site 997761007238 interdomain interaction site; other site 997761007239 metal binding site [ion binding]; metal-binding site 997761007240 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 997761007241 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 997761007242 Walker A motif; other site 997761007243 ATP binding site [chemical binding]; other site 997761007244 Walker B motif; other site 997761007245 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 997761007246 germination protein YpeB; Region: spore_YpeB; TIGR02889 997761007247 Flagellar protein YcgR; Region: YcgR_2; pfam12945 997761007248 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 997761007249 PilZ domain; Region: PilZ; pfam07238 997761007250 cytidylate kinase; Provisional; Region: cmk; PRK00023 997761007251 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 997761007252 CMP-binding site; other site 997761007253 The sites determining sugar specificity; other site 997761007254 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 997761007255 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 997761007256 putative acyl-acceptor binding pocket; other site 997761007257 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 997761007258 RNA binding site [nucleotide binding]; other site 997761007259 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 997761007260 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 997761007261 RNA binding site [nucleotide binding]; other site 997761007262 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 997761007263 RNA binding site [nucleotide binding]; other site 997761007264 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 997761007265 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 997761007266 homotetramer interface [polypeptide binding]; other site 997761007267 FMN binding site [chemical binding]; other site 997761007268 homodimer contacts [polypeptide binding]; other site 997761007269 putative active site [active] 997761007270 putative substrate binding site [chemical binding]; other site 997761007271 YIEGIA protein; Region: YIEGIA; pfam14045 997761007272 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 997761007273 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 997761007274 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 997761007275 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 997761007276 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 997761007277 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 997761007278 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 997761007279 catalytic loop [active] 997761007280 iron binding site [ion binding]; other site 997761007281 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 997761007282 metal binding triad [ion binding]; metal-binding site 997761007283 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 997761007284 catalytic loop [active] 997761007285 iron binding site [ion binding]; other site 997761007286 Protein of unknown function (DUF3939); Region: DUF3939; pfam13075 997761007287 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 997761007288 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 997761007289 G1 box; other site 997761007290 GTP/Mg2+ binding site [chemical binding]; other site 997761007291 G2 box; other site 997761007292 Switch I region; other site 997761007293 G3 box; other site 997761007294 Switch II region; other site 997761007295 G4 box; other site 997761007296 G5 box; other site 997761007297 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 997761007298 IHF - DNA interface [nucleotide binding]; other site 997761007299 IHF dimer interface [polypeptide binding]; other site 997761007300 transcription attenuation protein MtrB; Provisional; Region: PRK13251 997761007301 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 997761007302 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 997761007303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761007304 S-adenosylmethionine binding site [chemical binding]; other site 997761007305 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 997761007306 UbiA prenyltransferase family; Region: UbiA; pfam01040 997761007307 aromatic acid decarboxylase; Validated; Region: PRK05920 997761007308 Flavoprotein; Region: Flavoprotein; pfam02441 997761007309 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 997761007310 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 997761007311 substrate binding pocket [chemical binding]; other site 997761007312 chain length determination region; other site 997761007313 substrate-Mg2+ binding site; other site 997761007314 catalytic residues [active] 997761007315 aspartate-rich region 1; other site 997761007316 active site lid residues [active] 997761007317 aspartate-rich region 2; other site 997761007318 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 997761007319 active site 997761007320 multimer interface [polypeptide binding]; other site 997761007321 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 997761007322 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 997761007323 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761007324 S-adenosylmethionine binding site [chemical binding]; other site 997761007325 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 997761007326 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 997761007327 Tetramer interface [polypeptide binding]; other site 997761007328 active site 997761007329 FMN-binding site [chemical binding]; other site 997761007330 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 997761007331 active site 997761007332 dimer interface [polypeptide binding]; other site 997761007333 metal binding site [ion binding]; metal-binding site 997761007334 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 997761007335 homotrimer interaction site [polypeptide binding]; other site 997761007336 active site 997761007337 anthranilate synthase component I; Provisional; Region: PRK13569 997761007338 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 997761007339 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 997761007340 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 997761007341 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 997761007342 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 997761007343 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 997761007344 active site 997761007345 ribulose/triose binding site [chemical binding]; other site 997761007346 phosphate binding site [ion binding]; other site 997761007347 substrate (anthranilate) binding pocket [chemical binding]; other site 997761007348 product (indole) binding pocket [chemical binding]; other site 997761007349 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 997761007350 active site 997761007351 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 997761007352 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 997761007353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761007354 catalytic residue [active] 997761007355 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 997761007356 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 997761007357 substrate binding site [chemical binding]; other site 997761007358 active site 997761007359 catalytic residues [active] 997761007360 heterodimer interface [polypeptide binding]; other site 997761007361 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 997761007362 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761007363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761007364 homodimer interface [polypeptide binding]; other site 997761007365 catalytic residue [active] 997761007366 prephenate dehydrogenase; Validated; Region: PRK06545 997761007367 prephenate dehydrogenase; Validated; Region: PRK08507 997761007368 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 997761007369 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 997761007370 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761007371 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761007372 DNA binding residues [nucleotide binding] 997761007373 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 997761007374 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 997761007375 catalytic core [active] 997761007376 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 997761007377 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 997761007378 trimer interface [polypeptide binding]; other site 997761007379 putative metal binding site [ion binding]; other site 997761007380 IDEAL domain; Region: IDEAL; pfam08858 997761007381 Protein of unknown function (DUF2487); Region: DUF2487; pfam10673 997761007382 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 997761007383 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 997761007384 interchain domain interface [polypeptide binding]; other site 997761007385 intrachain domain interface; other site 997761007386 heme bH binding site [chemical binding]; other site 997761007387 Qi binding site; other site 997761007388 heme bL binding site [chemical binding]; other site 997761007389 Qo binding site; other site 997761007390 intrachain domain interface; other site 997761007391 Qi binding site; other site 997761007392 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 997761007393 interchain domain interface [polypeptide binding]; other site 997761007394 Qo binding site; other site 997761007395 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 997761007396 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 997761007397 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 997761007398 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 997761007399 Uncharacterized conserved protein [Function unknown]; Region: COG1284 997761007400 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 997761007401 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 997761007402 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 997761007403 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 997761007404 homodimer interface [polypeptide binding]; other site 997761007405 metal binding site [ion binding]; metal-binding site 997761007406 TPR repeat; Region: TPR_11; pfam13414 997761007407 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 997761007408 TPR motif; other site 997761007409 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 997761007410 dihydrodipicolinate reductase; Provisional; Region: PRK00048 997761007411 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 997761007412 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 997761007413 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 997761007414 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 997761007415 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 997761007416 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 997761007417 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 997761007418 active site 997761007419 NTP binding site [chemical binding]; other site 997761007420 metal binding triad [ion binding]; metal-binding site 997761007421 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 997761007422 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 997761007423 Biotin operon repressor [Transcription]; Region: BirA; COG1654 997761007424 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 997761007425 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 997761007426 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 997761007427 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 997761007428 oligomerization interface [polypeptide binding]; other site 997761007429 active site 997761007430 metal binding site [ion binding]; metal-binding site 997761007431 pantoate--beta-alanine ligase; Region: panC; TIGR00018 997761007432 Pantoate-beta-alanine ligase; Region: PanC; cd00560 997761007433 active site 997761007434 ATP-binding site [chemical binding]; other site 997761007435 pantoate-binding site; other site 997761007436 HXXH motif; other site 997761007437 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 997761007438 tetramerization interface [polypeptide binding]; other site 997761007439 active site 997761007440 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 997761007441 binding surface 997761007442 TPR repeat; Region: TPR_11; pfam13414 997761007443 TPR motif; other site 997761007444 Tetratricopeptide repeat; Region: TPR_12; pfam13424 997761007445 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 997761007446 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 997761007447 active site 997761007448 catalytic site [active] 997761007449 substrate binding site [chemical binding]; other site 997761007450 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 997761007451 ATP binding site [chemical binding]; other site 997761007452 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 997761007453 putative Mg++ binding site [ion binding]; other site 997761007454 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 997761007455 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 997761007456 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 997761007457 CoA binding domain; Region: CoA_binding; pfam02629 997761007458 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 997761007459 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 997761007460 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 997761007461 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 997761007462 active site 997761007463 putative substrate binding pocket [chemical binding]; other site 997761007464 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 997761007465 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 997761007466 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761007467 Walker A motif; other site 997761007468 ATP binding site [chemical binding]; other site 997761007469 Walker B motif; other site 997761007470 arginine finger; other site 997761007471 Peptidase family M41; Region: Peptidase_M41; pfam01434 997761007472 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761007473 AMIN domain; Region: AMIN; pfam11741 997761007474 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 997761007475 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 997761007476 active site 997761007477 metal binding site [ion binding]; metal-binding site 997761007478 Sporulation and spore germination; Region: Germane; cl11253 997761007479 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 997761007480 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 997761007481 minor groove reading motif; other site 997761007482 helix-hairpin-helix signature motif; other site 997761007483 substrate binding pocket [chemical binding]; other site 997761007484 active site 997761007485 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 997761007486 Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477 997761007487 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 997761007488 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761007489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761007490 Walker A/P-loop; other site 997761007491 ATP binding site [chemical binding]; other site 997761007492 Q-loop/lid; other site 997761007493 ABC transporter signature motif; other site 997761007494 Walker B; other site 997761007495 D-loop; other site 997761007496 H-loop/switch region; other site 997761007497 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 997761007498 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761007499 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 997761007500 Walker A/P-loop; other site 997761007501 ATP binding site [chemical binding]; other site 997761007502 Q-loop/lid; other site 997761007503 ABC transporter signature motif; other site 997761007504 Walker B; other site 997761007505 D-loop; other site 997761007506 H-loop/switch region; other site 997761007507 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 997761007508 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 997761007509 G5 domain; Region: G5; pfam07501 997761007510 Peptidase family M23; Region: Peptidase_M23; pfam01551 997761007511 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 997761007512 active site 997761007513 catalytic triad [active] 997761007514 oxyanion hole [active] 997761007515 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 997761007516 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 997761007517 Walker A/P-loop; other site 997761007518 ATP binding site [chemical binding]; other site 997761007519 Q-loop/lid; other site 997761007520 ABC transporter signature motif; other site 997761007521 Walker B; other site 997761007522 D-loop; other site 997761007523 H-loop/switch region; other site 997761007524 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 997761007525 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 997761007526 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 997761007527 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761007528 Mg2+ binding site [ion binding]; other site 997761007529 G-X-G motif; other site 997761007530 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 997761007531 anchoring element; other site 997761007532 dimer interface [polypeptide binding]; other site 997761007533 ATP binding site [chemical binding]; other site 997761007534 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 997761007535 active site 997761007536 metal binding site [ion binding]; metal-binding site 997761007537 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 997761007538 DNA gyrase subunit A; Validated; Region: PRK05560 997761007539 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 997761007540 CAP-like domain; other site 997761007541 active site 997761007542 primary dimer interface [polypeptide binding]; other site 997761007543 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 997761007544 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 997761007545 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 997761007546 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 997761007547 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 997761007548 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 997761007549 active site 997761007550 S-adenosylmethionine binding site [chemical binding]; other site 997761007551 Methyltransferase domain; Region: Methyltransf_26; pfam13659 997761007552 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 997761007553 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 997761007554 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761007555 catalytic residue [active] 997761007556 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761007557 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 997761007558 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 997761007559 glycogen branching enzyme; Provisional; Region: PRK12313 997761007560 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 997761007561 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 997761007562 active site 997761007563 catalytic site [active] 997761007564 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 997761007565 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 997761007566 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 997761007567 ligand binding site; other site 997761007568 oligomer interface; other site 997761007569 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 997761007570 dimer interface [polypeptide binding]; other site 997761007571 N-terminal domain interface [polypeptide binding]; other site 997761007572 sulfate 1 binding site; other site 997761007573 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 997761007574 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 997761007575 ligand binding site; other site 997761007576 oligomer interface; other site 997761007577 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 997761007578 dimer interface [polypeptide binding]; other site 997761007579 N-terminal domain interface [polypeptide binding]; other site 997761007580 sulfate 1 binding site; other site 997761007581 glycogen synthase; Provisional; Region: glgA; PRK00654 997761007582 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 997761007583 ADP-binding pocket [chemical binding]; other site 997761007584 homodimer interface [polypeptide binding]; other site 997761007585 GAF domain; Region: GAF; pfam01590 997761007586 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 997761007587 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761007588 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761007589 dimer interface [polypeptide binding]; other site 997761007590 phosphorylation site [posttranslational modification] 997761007591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761007592 ATP binding site [chemical binding]; other site 997761007593 Mg2+ binding site [ion binding]; other site 997761007594 G-X-G motif; other site 997761007595 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 997761007596 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 997761007597 Cache domain; Region: Cache_1; pfam02743 997761007598 PAS domain S-box; Region: sensory_box; TIGR00229 997761007599 PAS domain S-box; Region: sensory_box; TIGR00229 997761007600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761007601 putative active site [active] 997761007602 heme pocket [chemical binding]; other site 997761007603 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761007604 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761007605 metal binding site [ion binding]; metal-binding site 997761007606 active site 997761007607 I-site; other site 997761007608 Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861 997761007609 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 997761007610 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761007611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761007612 active site 997761007613 phosphorylation site [posttranslational modification] 997761007614 intermolecular recognition site; other site 997761007615 dimerization interface [polypeptide binding]; other site 997761007616 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761007617 DNA binding site [nucleotide binding] 997761007618 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761007619 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761007620 dimerization interface [polypeptide binding]; other site 997761007621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761007622 dimer interface [polypeptide binding]; other site 997761007623 phosphorylation site [posttranslational modification] 997761007624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761007625 ATP binding site [chemical binding]; other site 997761007626 Mg2+ binding site [ion binding]; other site 997761007627 G-X-G motif; other site 997761007628 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 997761007629 active site clefts [active] 997761007630 zinc binding site [ion binding]; other site 997761007631 dimer interface [polypeptide binding]; other site 997761007632 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 997761007633 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 997761007634 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 997761007635 active site 997761007636 Zn binding site [ion binding]; other site 997761007637 Spore germination protein; Region: Spore_permease; cl17796 997761007638 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761007639 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761007640 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761007641 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 997761007642 NMT1-like family; Region: NMT1_2; pfam13379 997761007643 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 997761007644 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 997761007645 Walker A/P-loop; other site 997761007646 ATP binding site [chemical binding]; other site 997761007647 Q-loop/lid; other site 997761007648 ABC transporter signature motif; other site 997761007649 Walker B; other site 997761007650 D-loop; other site 997761007651 H-loop/switch region; other site 997761007652 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 997761007653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761007654 dimer interface [polypeptide binding]; other site 997761007655 conserved gate region; other site 997761007656 putative PBP binding loops; other site 997761007657 ABC-ATPase subunit interface; other site 997761007658 Predicted membrane protein [Function unknown]; Region: COG4129 997761007659 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 997761007660 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 997761007661 Outer spore coat protein E (CotE); Region: CotE; pfam10628 997761007662 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 997761007663 MutS domain I; Region: MutS_I; pfam01624 997761007664 MutS domain II; Region: MutS_II; pfam05188 997761007665 MutS domain III; Region: MutS_III; pfam05192 997761007666 MutS domain V; Region: MutS_V; pfam00488 997761007667 Walker A/P-loop; other site 997761007668 ATP binding site [chemical binding]; other site 997761007669 Q-loop/lid; other site 997761007670 ABC transporter signature motif; other site 997761007671 Walker B; other site 997761007672 D-loop; other site 997761007673 H-loop/switch region; other site 997761007674 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 997761007675 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 997761007676 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 997761007677 protein binding site [polypeptide binding]; other site 997761007678 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 997761007679 Catalytic dyad [active] 997761007680 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761007681 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 997761007682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761007683 S-adenosylmethionine binding site [chemical binding]; other site 997761007684 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 997761007685 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 997761007686 bacterial Hfq-like; Region: Hfq; cd01716 997761007687 hexamer interface [polypeptide binding]; other site 997761007688 Sm1 motif; other site 997761007689 RNA binding site [nucleotide binding]; other site 997761007690 Sm2 motif; other site 997761007691 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 997761007692 active site 997761007693 Esterase/lipase [General function prediction only]; Region: COG1647 997761007694 PGAP1-like protein; Region: PGAP1; pfam07819 997761007695 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 997761007696 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761007697 active site 997761007698 metal binding site [ion binding]; metal-binding site 997761007699 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 997761007700 Uncharacterized conserved protein [Function unknown]; Region: COG1434 997761007701 putative active site [active] 997761007702 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 997761007703 short chain dehydrogenase; Provisional; Region: PRK06701 997761007704 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 997761007705 NAD binding site [chemical binding]; other site 997761007706 metal binding site [ion binding]; metal-binding site 997761007707 active site 997761007708 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 997761007709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761007710 motif II; other site 997761007711 stage V sporulation protein K; Region: spore_V_K; TIGR02881 997761007712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761007713 Walker A motif; other site 997761007714 ATP binding site [chemical binding]; other site 997761007715 Walker B motif; other site 997761007716 arginine finger; other site 997761007717 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 997761007718 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 997761007719 HflX GTPase family; Region: HflX; cd01878 997761007720 G1 box; other site 997761007721 GTP/Mg2+ binding site [chemical binding]; other site 997761007722 Switch I region; other site 997761007723 G2 box; other site 997761007724 G3 box; other site 997761007725 Switch II region; other site 997761007726 G4 box; other site 997761007727 G5 box; other site 997761007728 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 997761007729 Aluminium resistance protein; Region: Alum_res; pfam06838 997761007730 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 997761007731 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 997761007732 DNA binding residues [nucleotide binding] 997761007733 putative dimer interface [polypeptide binding]; other site 997761007734 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 997761007735 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 997761007736 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 997761007737 LexA repressor; Validated; Region: PRK00215 997761007738 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761007739 putative DNA binding site [nucleotide binding]; other site 997761007740 putative Zn2+ binding site [ion binding]; other site 997761007741 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 997761007742 Catalytic site [active] 997761007743 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 997761007744 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761007745 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761007746 active site 997761007747 catalytic tetrad [active] 997761007748 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 997761007749 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761007750 motif II; other site 997761007751 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 997761007752 Cupin domain; Region: Cupin_2; cl17218 997761007753 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 997761007754 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 997761007755 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 997761007756 substrate binding pocket [chemical binding]; other site 997761007757 dimer interface [polypeptide binding]; other site 997761007758 inhibitor binding site; inhibition site 997761007759 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 997761007760 B12 binding site [chemical binding]; other site 997761007761 cobalt ligand [ion binding]; other site 997761007762 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 997761007763 ribonuclease Z; Region: RNase_Z; TIGR02651 997761007764 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 997761007765 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 997761007766 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 997761007767 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 997761007768 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 997761007769 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 997761007770 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 997761007771 putative acyl-acceptor binding pocket; other site 997761007772 phytoene desaturase; Region: crtI_fam; TIGR02734 997761007773 Protein of unknown function (DUF422); Region: DUF422; cl00991 997761007774 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 997761007775 active site lid residues [active] 997761007776 substrate binding pocket [chemical binding]; other site 997761007777 catalytic residues [active] 997761007778 substrate-Mg2+ binding site; other site 997761007779 aspartate-rich region 1; other site 997761007780 aspartate-rich region 2; other site 997761007781 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 997761007782 phytoene desaturase; Region: crtI_fam; TIGR02734 997761007783 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 997761007784 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 997761007785 ATP binding site [chemical binding]; other site 997761007786 putative Mg++ binding site [ion binding]; other site 997761007787 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 997761007788 nucleotide binding region [chemical binding]; other site 997761007789 ATP-binding site [chemical binding]; other site 997761007790 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 997761007791 RNase_H superfamily; Region: RNase_H_2; pfam13482 997761007792 active site 997761007793 substrate binding site [chemical binding]; other site 997761007794 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 997761007795 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 997761007796 putative DNA binding site [nucleotide binding]; other site 997761007797 catalytic residue [active] 997761007798 putative H2TH interface [polypeptide binding]; other site 997761007799 putative catalytic residues [active] 997761007800 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 997761007801 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 997761007802 AP endonuclease family 2; Region: AP2Ec; smart00518 997761007803 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 997761007804 AP (apurinic/apyrimidinic) site pocket; other site 997761007805 DNA interaction; other site 997761007806 Metal-binding active site; metal-binding site 997761007807 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 997761007808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761007809 Walker A/P-loop; other site 997761007810 ATP binding site [chemical binding]; other site 997761007811 Q-loop/lid; other site 997761007812 ABC transporter signature motif; other site 997761007813 Walker B; other site 997761007814 D-loop; other site 997761007815 H-loop/switch region; other site 997761007816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761007817 S-adenosylmethionine binding site [chemical binding]; other site 997761007818 Methyltransferase domain; Region: Methyltransf_31; pfam13847 997761007819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761007820 S-adenosylmethionine binding site [chemical binding]; other site 997761007821 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 997761007822 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 997761007823 ATP binding site [chemical binding]; other site 997761007824 Walker A motif; other site 997761007825 hexamer interface [polypeptide binding]; other site 997761007826 Walker B motif; other site 997761007827 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 997761007828 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 997761007829 Domain of unknown function (DUF955); Region: DUF955; pfam06114 997761007830 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 997761007831 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 997761007832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761007833 non-specific DNA binding site [nucleotide binding]; other site 997761007834 salt bridge; other site 997761007835 sequence-specific DNA binding site [nucleotide binding]; other site 997761007836 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 997761007837 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 997761007838 RecT family; Region: RecT; cl04285 997761007839 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 997761007840 Replication initiation and membrane attachment; Region: DnaB_2; cl12121 997761007841 replicative DNA helicase; Region: DnaB; TIGR00665 997761007842 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 997761007843 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 997761007844 Walker A motif; other site 997761007845 ATP binding site [chemical binding]; other site 997761007846 Walker B motif; other site 997761007847 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 997761007848 active site 997761007849 putative DNA-binding cleft [nucleotide binding]; other site 997761007850 dimer interface [polypeptide binding]; other site 997761007851 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 997761007852 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 997761007853 active site 997761007854 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 997761007855 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 997761007856 Phage capsid family; Region: Phage_capsid; pfam05065 997761007857 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 997761007858 oligomerization interface [polypeptide binding]; other site 997761007859 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 997761007860 phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603 997761007861 Phage tail protein; Region: Sipho_tail; cl17486 997761007862 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 997761007863 amidase catalytic site [active] 997761007864 Zn binding residues [ion binding]; other site 997761007865 substrate binding site [chemical binding]; other site 997761007866 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 997761007867 Helix-turn-helix domain; Region: HTH_36; pfam13730 997761007868 Phosphotransferase enzyme family; Region: APH; pfam01636 997761007869 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 997761007870 active site 997761007871 ATP binding site [chemical binding]; other site 997761007872 substrate binding site [chemical binding]; other site 997761007873 Helix-turn-helix domain; Region: HTH_36; pfam13730 997761007874 MutS domain I; Region: MutS_I; pfam01624 997761007875 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 997761007876 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 997761007877 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 997761007878 Walker A/P-loop; other site 997761007879 ATP binding site [chemical binding]; other site 997761007880 Q-loop/lid; other site 997761007881 ABC transporter signature motif; other site 997761007882 Walker B; other site 997761007883 D-loop; other site 997761007884 H-loop/switch region; other site 997761007885 Predicted transcriptional regulators [Transcription]; Region: COG1725 997761007886 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761007887 DNA-binding site [nucleotide binding]; DNA binding site 997761007888 Helix-turn-helix domain; Region: HTH_36; pfam13730 997761007889 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 997761007890 active site 997761007891 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 997761007892 metal binding site [ion binding]; metal-binding site 997761007893 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 997761007894 active site 997761007895 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 997761007896 Protein of unknown function (DUF3888); Region: DUF3888; pfam13027 997761007897 TadE-like protein; Region: TadE; pfam07811 997761007898 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 997761007899 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 997761007900 phosphopeptide binding site; other site 997761007901 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 997761007902 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 997761007903 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 997761007904 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 997761007905 putative oligomer interface [polypeptide binding]; other site 997761007906 putative active site [active] 997761007907 metal binding site [ion binding]; metal-binding site 997761007908 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 997761007909 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761007910 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761007911 ABC transporter; Region: ABC_tran_2; pfam12848 997761007912 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761007913 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 997761007914 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761007915 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761007916 ABC transporter; Region: ABC_tran_2; pfam12848 997761007917 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761007918 Kinase associated protein B; Region: KapB; pfam08810 997761007919 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761007920 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761007921 ATP binding site [chemical binding]; other site 997761007922 Mg2+ binding site [ion binding]; other site 997761007923 G-X-G motif; other site 997761007924 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761007925 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761007926 active site 997761007927 phosphorylation site [posttranslational modification] 997761007928 intermolecular recognition site; other site 997761007929 dimerization interface [polypeptide binding]; other site 997761007930 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761007931 DNA binding residues [nucleotide binding] 997761007932 dimerization interface [polypeptide binding]; other site 997761007933 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761007934 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761007935 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761007936 Predicted membrane protein [Function unknown]; Region: COG2860 997761007937 UPF0126 domain; Region: UPF0126; pfam03458 997761007938 UPF0126 domain; Region: UPF0126; pfam03458 997761007939 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 997761007940 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 997761007941 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 997761007942 sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898 997761007943 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 997761007944 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761007945 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761007946 active site 997761007947 phosphorylation site [posttranslational modification] 997761007948 intermolecular recognition site; other site 997761007949 dimerization interface [polypeptide binding]; other site 997761007950 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761007951 DNA binding site [nucleotide binding] 997761007952 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 997761007953 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761007954 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761007955 dimerization interface [polypeptide binding]; other site 997761007956 putative DNA binding site [nucleotide binding]; other site 997761007957 putative Zn2+ binding site [ion binding]; other site 997761007958 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 997761007959 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 997761007960 ATP-grasp domain; Region: ATP-grasp; pfam02222 997761007961 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 997761007962 Predicted membrane protein [Function unknown]; Region: COG4682 997761007963 yiaA/B two helix domain; Region: YiaAB; pfam05360 997761007964 yiaA/B two helix domain; Region: YiaAB; pfam05360 997761007965 Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129 997761007966 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 997761007967 active site 997761007968 metal binding site [ion binding]; metal-binding site 997761007969 homotetramer interface [polypeptide binding]; other site 997761007970 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 997761007971 S-formylglutathione hydrolase; Region: PLN02442 997761007972 Putative esterase; Region: Esterase; pfam00756 997761007973 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761007974 TIGR01777 family protein; Region: yfcH 997761007975 NAD(P) binding site [chemical binding]; other site 997761007976 active site 997761007977 DNA topoisomerase III; Provisional; Region: PRK07726 997761007978 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 997761007979 active site 997761007980 putative interdomain interaction site [polypeptide binding]; other site 997761007981 putative metal-binding site [ion binding]; other site 997761007982 putative nucleotide binding site [chemical binding]; other site 997761007983 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 997761007984 domain I; other site 997761007985 DNA binding groove [nucleotide binding] 997761007986 phosphate binding site [ion binding]; other site 997761007987 domain II; other site 997761007988 domain III; other site 997761007989 nucleotide binding site [chemical binding]; other site 997761007990 catalytic site [active] 997761007991 domain IV; other site 997761007992 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 997761007993 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761007994 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761007995 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761007996 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761007997 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761007998 active site 997761007999 catalytic tetrad [active] 997761008000 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 997761008001 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 997761008002 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 997761008003 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 997761008004 putative NAD(P) binding site [chemical binding]; other site 997761008005 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761008006 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761008007 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761008008 dimerization interface [polypeptide binding]; other site 997761008009 putative DNA binding site [nucleotide binding]; other site 997761008010 putative Zn2+ binding site [ion binding]; other site 997761008011 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 997761008012 hydrophobic ligand binding site; other site 997761008013 Methyltransferase domain; Region: Methyltransf_31; pfam13847 997761008014 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761008015 S-adenosylmethionine binding site [chemical binding]; other site 997761008016 Predicted amidohydrolase [General function prediction only]; Region: COG0388 997761008017 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 997761008018 putative active site [active] 997761008019 catalytic triad [active] 997761008020 putative dimer interface [polypeptide binding]; other site 997761008021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 997761008022 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 997761008023 E-class dimer interface [polypeptide binding]; other site 997761008024 P-class dimer interface [polypeptide binding]; other site 997761008025 active site 997761008026 Cu2+ binding site [ion binding]; other site 997761008027 Zn2+ binding site [ion binding]; other site 997761008028 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761008029 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761008030 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761008031 dimerization interface [polypeptide binding]; other site 997761008032 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 997761008033 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 997761008034 GDP-binding site [chemical binding]; other site 997761008035 ACT binding site; other site 997761008036 IMP binding site; other site 997761008037 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 997761008038 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 997761008039 regulatory ATPase RavA; Provisional; Region: PRK13531 997761008040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761008041 Walker A motif; other site 997761008042 ATP binding site [chemical binding]; other site 997761008043 Walker B motif; other site 997761008044 arginine finger; other site 997761008045 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 997761008046 catalytic residues [active] 997761008047 dimer interface [polypeptide binding]; other site 997761008048 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 997761008049 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 997761008050 Ligand Binding Site [chemical binding]; other site 997761008051 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 997761008052 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 997761008053 Walker A/P-loop; other site 997761008054 ATP binding site [chemical binding]; other site 997761008055 Q-loop/lid; other site 997761008056 ABC transporter signature motif; other site 997761008057 Walker B; other site 997761008058 D-loop; other site 997761008059 H-loop/switch region; other site 997761008060 FtsX-like permease family; Region: FtsX; pfam02687 997761008061 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 997761008062 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 997761008063 acyl-activating enzyme (AAE) consensus motif; other site 997761008064 AMP binding site [chemical binding]; other site 997761008065 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761008066 Condensation domain; Region: Condensation; pfam00668 997761008067 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 997761008068 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 997761008069 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 997761008070 acyl-activating enzyme (AAE) consensus motif; other site 997761008071 AMP binding site [chemical binding]; other site 997761008072 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761008073 Condensation domain; Region: Condensation; pfam00668 997761008074 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 997761008075 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 997761008076 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 997761008077 acyl-activating enzyme (AAE) consensus motif; other site 997761008078 AMP binding site [chemical binding]; other site 997761008079 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761008080 Condensation domain; Region: Condensation; pfam00668 997761008081 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 997761008082 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 997761008083 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 997761008084 acyl-activating enzyme (AAE) consensus motif; other site 997761008085 AMP binding site [chemical binding]; other site 997761008086 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761008087 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 997761008088 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761008089 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761008090 active site 997761008091 phosphorylation site [posttranslational modification] 997761008092 intermolecular recognition site; other site 997761008093 dimerization interface [polypeptide binding]; other site 997761008094 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761008095 DNA binding site [nucleotide binding] 997761008096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761008097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761008098 ATP binding site [chemical binding]; other site 997761008099 Mg2+ binding site [ion binding]; other site 997761008100 G-X-G motif; other site 997761008101 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761008102 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761008103 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 997761008104 Family description; Region: UvrD_C_2; pfam13538 997761008105 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 997761008106 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761008107 non-specific DNA binding site [nucleotide binding]; other site 997761008108 salt bridge; other site 997761008109 sequence-specific DNA binding site [nucleotide binding]; other site 997761008110 fumarate hydratase; Reviewed; Region: fumC; PRK00485 997761008111 Class II fumarases; Region: Fumarase_classII; cd01362 997761008112 active site 997761008113 tetramer interface [polypeptide binding]; other site 997761008114 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 997761008115 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 997761008116 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 997761008117 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 997761008118 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 997761008119 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 997761008120 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 997761008121 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761008122 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 997761008123 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 997761008124 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 997761008125 Peptidase family M23; Region: Peptidase_M23; pfam01551 997761008126 H+ Antiporter protein; Region: 2A0121; TIGR00900 997761008127 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 997761008128 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 997761008129 HAMP domain; Region: HAMP; pfam00672 997761008130 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761008131 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761008132 dimer interface [polypeptide binding]; other site 997761008133 putative CheW interface [polypeptide binding]; other site 997761008134 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 997761008135 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 997761008136 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 997761008137 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 997761008138 metal binding site 2 [ion binding]; metal-binding site 997761008139 putative DNA binding helix; other site 997761008140 metal binding site 1 [ion binding]; metal-binding site 997761008141 dimer interface [polypeptide binding]; other site 997761008142 structural Zn2+ binding site [ion binding]; other site 997761008143 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761008144 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 997761008145 substrate binding pocket [chemical binding]; other site 997761008146 membrane-bound complex binding site; other site 997761008147 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 997761008148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008149 dimer interface [polypeptide binding]; other site 997761008150 conserved gate region; other site 997761008151 putative PBP binding loops; other site 997761008152 ABC-ATPase subunit interface; other site 997761008153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008154 dimer interface [polypeptide binding]; other site 997761008155 conserved gate region; other site 997761008156 putative PBP binding loops; other site 997761008157 ABC-ATPase subunit interface; other site 997761008158 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 997761008159 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 997761008160 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 997761008161 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 997761008162 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 997761008163 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 997761008164 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761008165 substrate binding pocket [chemical binding]; other site 997761008166 membrane-bound complex binding site; other site 997761008167 hinge residues; other site 997761008168 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 997761008169 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 997761008170 active site 997761008171 dimer interface [polypeptide binding]; other site 997761008172 non-prolyl cis peptide bond; other site 997761008173 insertion regions; other site 997761008174 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 997761008175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008176 dimer interface [polypeptide binding]; other site 997761008177 conserved gate region; other site 997761008178 putative PBP binding loops; other site 997761008179 ABC-ATPase subunit interface; other site 997761008180 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 997761008181 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 997761008182 Walker A/P-loop; other site 997761008183 ATP binding site [chemical binding]; other site 997761008184 Q-loop/lid; other site 997761008185 ABC transporter signature motif; other site 997761008186 Walker B; other site 997761008187 D-loop; other site 997761008188 H-loop/switch region; other site 997761008189 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 997761008190 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 997761008191 Walker A/P-loop; other site 997761008192 ATP binding site [chemical binding]; other site 997761008193 Q-loop/lid; other site 997761008194 ABC transporter signature motif; other site 997761008195 Walker B; other site 997761008196 D-loop; other site 997761008197 H-loop/switch region; other site 997761008198 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 997761008199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008200 dimer interface [polypeptide binding]; other site 997761008201 conserved gate region; other site 997761008202 putative PBP binding loops; other site 997761008203 ABC-ATPase subunit interface; other site 997761008204 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 997761008205 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761008206 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761008207 active site 997761008208 catalytic tetrad [active] 997761008209 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 997761008210 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761008211 substrate binding pocket [chemical binding]; other site 997761008212 membrane-bound complex binding site; other site 997761008213 hinge residues; other site 997761008214 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 997761008215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008216 dimer interface [polypeptide binding]; other site 997761008217 conserved gate region; other site 997761008218 ABC-ATPase subunit interface; other site 997761008219 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 997761008220 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 997761008221 Walker A/P-loop; other site 997761008222 ATP binding site [chemical binding]; other site 997761008223 Q-loop/lid; other site 997761008224 ABC transporter signature motif; other site 997761008225 Walker B; other site 997761008226 D-loop; other site 997761008227 H-loop/switch region; other site 997761008228 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 997761008229 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 997761008230 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 997761008231 metal binding site [ion binding]; metal-binding site 997761008232 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 997761008233 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 997761008234 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761008235 Walker A/P-loop; other site 997761008236 ATP binding site [chemical binding]; other site 997761008237 Q-loop/lid; other site 997761008238 ABC transporter signature motif; other site 997761008239 Walker B; other site 997761008240 D-loop; other site 997761008241 H-loop/switch region; other site 997761008242 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 997761008243 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 997761008244 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 997761008245 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 997761008246 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 997761008247 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 997761008248 AAA domain; Region: AAA_18; pfam13238 997761008249 ATP-binding site [chemical binding]; other site 997761008250 Sugar specificity; other site 997761008251 Pyrimidine base specificity; other site 997761008252 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 997761008253 classical (c) SDRs; Region: SDR_c; cd05233 997761008254 NAD(P) binding site [chemical binding]; other site 997761008255 active site 997761008256 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 997761008257 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 997761008258 Ca binding site [ion binding]; other site 997761008259 active site 997761008260 catalytic site [active] 997761008261 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 997761008262 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 997761008263 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 997761008264 dimer interface [polypeptide binding]; other site 997761008265 active site 997761008266 metal binding site [ion binding]; metal-binding site 997761008267 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 997761008268 nucleotide binding site/active site [active] 997761008269 HIT family signature motif; other site 997761008270 catalytic residue [active] 997761008271 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761008272 Coenzyme A binding pocket [chemical binding]; other site 997761008273 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 997761008274 tetracycline repressor protein TetR; Provisional; Region: PRK13756 997761008275 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761008276 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 997761008277 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 997761008278 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761008279 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761008280 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 997761008281 Transcriptional regulators [Transcription]; Region: FadR; COG2186 997761008282 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761008283 DNA-binding site [nucleotide binding]; DNA binding site 997761008284 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 997761008285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761008286 D-galactonate transporter; Region: 2A0114; TIGR00893 997761008287 putative substrate translocation pore; other site 997761008288 transketolase; Reviewed; Region: PRK05899 997761008289 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 997761008290 TPP-binding site [chemical binding]; other site 997761008291 dimer interface [polypeptide binding]; other site 997761008292 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 997761008293 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 997761008294 PYR/PP interface [polypeptide binding]; other site 997761008295 dimer interface [polypeptide binding]; other site 997761008296 TPP binding site [chemical binding]; other site 997761008297 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 997761008298 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 997761008299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761008300 NAD(P) binding site [chemical binding]; other site 997761008301 active site 997761008302 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 997761008303 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 997761008304 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761008305 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761008306 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761008307 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 997761008308 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 997761008309 Walker A/P-loop; other site 997761008310 ATP binding site [chemical binding]; other site 997761008311 Q-loop/lid; other site 997761008312 ABC transporter signature motif; other site 997761008313 Walker B; other site 997761008314 D-loop; other site 997761008315 H-loop/switch region; other site 997761008316 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761008317 ABC-ATPase subunit interface; other site 997761008318 dimer interface [polypeptide binding]; other site 997761008319 putative PBP binding regions; other site 997761008320 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 997761008321 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761008322 ABC-ATPase subunit interface; other site 997761008323 dimer interface [polypeptide binding]; other site 997761008324 putative PBP binding regions; other site 997761008325 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 997761008326 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 997761008327 intersubunit interface [polypeptide binding]; other site 997761008328 Predicted membrane protein [Function unknown]; Region: COG2364 997761008329 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 997761008330 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761008331 Coenzyme A binding pocket [chemical binding]; other site 997761008332 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761008333 MarR family; Region: MarR; pfam01047 997761008334 DoxX-like family; Region: DoxX_2; pfam13564 997761008335 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761008336 dimerization interface [polypeptide binding]; other site 997761008337 putative DNA binding site [nucleotide binding]; other site 997761008338 putative Zn2+ binding site [ion binding]; other site 997761008339 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 997761008340 putative hydrophobic ligand binding site [chemical binding]; other site 997761008341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 997761008342 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 997761008343 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 997761008344 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 997761008345 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 997761008346 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 997761008347 DNA binding residues [nucleotide binding] 997761008348 putative dimer interface [polypeptide binding]; other site 997761008349 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 997761008350 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 997761008351 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761008352 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761008353 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 997761008354 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 997761008355 putative NAD(P) binding site [chemical binding]; other site 997761008356 putative substrate binding site [chemical binding]; other site 997761008357 catalytic Zn binding site [ion binding]; other site 997761008358 structural Zn binding site [ion binding]; other site 997761008359 dimer interface [polypeptide binding]; other site 997761008360 Uncharacterized conserved protein [Function unknown]; Region: COG4925 997761008361 Domain of unknown function (DUF4317); Region: DUF4317; pfam14199 997761008362 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761008363 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761008364 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761008365 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 997761008366 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 997761008367 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 997761008368 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761008369 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761008370 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761008371 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761008372 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 997761008373 classical (c) SDRs; Region: SDR_c; cd05233 997761008374 NAD(P) binding site [chemical binding]; other site 997761008375 active site 997761008376 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 997761008377 Predicted transcriptional regulators [Transcription]; Region: COG1695 997761008378 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 997761008379 CAAX protease self-immunity; Region: Abi; pfam02517 997761008380 serine/threonine transporter SstT; Provisional; Region: PRK13628 997761008381 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 997761008382 Uncharacterized conserved protein [Function unknown]; Region: COG1359 997761008383 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 997761008384 dimer interface [polypeptide binding]; other site 997761008385 FMN binding site [chemical binding]; other site 997761008386 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761008387 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761008388 putative DNA binding site [nucleotide binding]; other site 997761008389 putative Zn2+ binding site [ion binding]; other site 997761008390 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 997761008391 catalytic core [active] 997761008392 Phosphotransferase enzyme family; Region: APH; pfam01636 997761008393 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 997761008394 active site 997761008395 substrate binding site [chemical binding]; other site 997761008396 ATP binding site [chemical binding]; other site 997761008397 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 997761008398 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 997761008399 Phosphotransferase enzyme family; Region: APH; pfam01636 997761008400 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 997761008401 active site 997761008402 substrate binding site [chemical binding]; other site 997761008403 ATP binding site [chemical binding]; other site 997761008404 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 997761008405 Helix-turn-helix domain; Region: HTH_17; pfam12728 997761008406 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 997761008407 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 997761008408 putative oxidoreductase; Provisional; Region: PRK08275 997761008409 L-aspartate oxidase; Provisional; Region: PRK06175 997761008410 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 997761008411 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 997761008412 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 997761008413 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 997761008414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008415 dimer interface [polypeptide binding]; other site 997761008416 conserved gate region; other site 997761008417 putative PBP binding loops; other site 997761008418 ABC-ATPase subunit interface; other site 997761008419 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 997761008420 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 997761008421 Walker A/P-loop; other site 997761008422 ATP binding site [chemical binding]; other site 997761008423 Q-loop/lid; other site 997761008424 ABC transporter signature motif; other site 997761008425 Walker B; other site 997761008426 D-loop; other site 997761008427 H-loop/switch region; other site 997761008428 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761008429 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 997761008430 active site 997761008431 metal binding site [ion binding]; metal-binding site 997761008432 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 997761008433 dimer interface [polypeptide binding]; other site 997761008434 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761008435 ligand binding site [chemical binding]; other site 997761008436 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761008437 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761008438 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 997761008439 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 997761008440 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 997761008441 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761008442 S-adenosylmethionine binding site [chemical binding]; other site 997761008443 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 997761008444 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 997761008445 Coenzyme A binding pocket [chemical binding]; other site 997761008446 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761008447 S-adenosylmethionine binding site [chemical binding]; other site 997761008448 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761008449 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761008450 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761008451 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761008452 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761008453 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 997761008454 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 997761008455 A new structural DNA glycosylase; Region: AlkD_like; cd06561 997761008456 active site 997761008457 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761008458 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761008459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761008460 S-adenosylmethionine binding site [chemical binding]; other site 997761008461 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 997761008462 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 997761008463 active site 997761008464 catalytic triad [active] 997761008465 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 997761008466 catalytic residues [active] 997761008467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 997761008468 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 997761008469 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 997761008470 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 997761008471 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 997761008472 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 997761008473 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 997761008474 XdhC Rossmann domain; Region: XdhC_C; pfam13478 997761008475 xanthine dehydrogenase C subunit; Region: pucC; TIGR03199 997761008476 xanthine dehydrogenase D subunit; Region: pucD; TIGR03196 997761008477 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 997761008478 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 997761008479 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 997761008480 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111 997761008481 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 997761008482 NMT1/THI5 like; Region: NMT1; pfam09084 997761008483 Response regulator receiver domain; Region: Response_reg; pfam00072 997761008484 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761008485 active site 997761008486 phosphorylation site [posttranslational modification] 997761008487 intermolecular recognition site; other site 997761008488 dimerization interface [polypeptide binding]; other site 997761008489 Creatinine amidohydrolase; Region: Creatininase; pfam02633 997761008490 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 997761008491 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 997761008492 Walker A/P-loop; other site 997761008493 ATP binding site [chemical binding]; other site 997761008494 Q-loop/lid; other site 997761008495 ABC transporter signature motif; other site 997761008496 Walker B; other site 997761008497 D-loop; other site 997761008498 H-loop/switch region; other site 997761008499 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 997761008500 FAD binding domain; Region: FAD_binding_4; pfam01565 997761008501 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 997761008502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008503 dimer interface [polypeptide binding]; other site 997761008504 conserved gate region; other site 997761008505 ABC-ATPase subunit interface; other site 997761008506 cytosine deaminase; Provisional; Region: PRK09230 997761008507 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 997761008508 active site 997761008509 NMT1/THI5 like; Region: NMT1; pfam09084 997761008510 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761008511 substrate binding pocket [chemical binding]; other site 997761008512 hinge residues; other site 997761008513 OHCU decarboxylase; Region: OHCU_decarbox; cl01251 997761008514 Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648 997761008515 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 997761008516 active site 997761008517 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 997761008518 active site 997761008519 homotetramer interface [polypeptide binding]; other site 997761008520 allantoinase; Provisional; Region: PRK06189 997761008521 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 997761008522 active site 997761008523 allantoate amidohydrolase; Reviewed; Region: PRK09290 997761008524 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 997761008525 active site 997761008526 metal binding site [ion binding]; metal-binding site 997761008527 dimer interface [polypeptide binding]; other site 997761008528 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 997761008529 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 997761008530 catalytic residue [active] 997761008531 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 997761008532 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 997761008533 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 997761008534 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 997761008535 2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537 997761008536 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144 997761008537 4Fe-4S binding domain; Region: Fer4; cl02805 997761008538 4Fe-4S binding domain; Region: Fer4; pfam00037 997761008539 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 997761008540 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 997761008541 dimer interface [polypeptide binding]; other site 997761008542 PYR/PP interface [polypeptide binding]; other site 997761008543 TPP binding site [chemical binding]; other site 997761008544 substrate binding site [chemical binding]; other site 997761008545 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 997761008546 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 997761008547 TPP-binding site [chemical binding]; other site 997761008548 DoxX-like family; Region: DoxX_2; pfam13564 997761008549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761008550 Coenzyme A binding pocket [chemical binding]; other site 997761008551 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 997761008552 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761008553 Coenzyme A binding pocket [chemical binding]; other site 997761008554 short chain dehydrogenase; Provisional; Region: PRK06180 997761008555 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 997761008556 NADP binding site [chemical binding]; other site 997761008557 active site 997761008558 steroid binding site; other site 997761008559 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 997761008560 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 997761008561 EamA-like transporter family; Region: EamA; pfam00892 997761008562 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 997761008563 EamA-like transporter family; Region: EamA; pfam00892 997761008564 EamA-like transporter family; Region: EamA; pfam00892 997761008565 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 997761008566 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 997761008567 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761008568 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761008569 active site 997761008570 phosphorylation site [posttranslational modification] 997761008571 intermolecular recognition site; other site 997761008572 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761008573 DNA binding site [nucleotide binding] 997761008574 peptide synthase; Provisional; Region: PRK12316 997761008575 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 997761008576 Uncharacterized conserved protein [Function unknown]; Region: COG1434 997761008577 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 997761008578 putative active site [active] 997761008579 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 997761008580 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 997761008581 NADP binding site [chemical binding]; other site 997761008582 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 997761008583 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 997761008584 catalytic residues [active] 997761008585 FlaG protein; Region: FlaG; pfam03646 997761008586 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 997761008587 alanine racemase; Reviewed; Region: alr; PRK00053 997761008588 active site 997761008589 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 997761008590 dimer interface [polypeptide binding]; other site 997761008591 substrate binding site [chemical binding]; other site 997761008592 catalytic residues [active] 997761008593 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 997761008594 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 997761008595 hexamer interface [polypeptide binding]; other site 997761008596 ligand binding site [chemical binding]; other site 997761008597 putative active site [active] 997761008598 NAD(P) binding site [chemical binding]; other site 997761008599 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 997761008600 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 997761008601 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 997761008602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761008603 S-adenosylmethionine binding site [chemical binding]; other site 997761008604 Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162 997761008605 Protein of unknown function (DUF2533); Region: DUF2533; pfam10752 997761008606 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692 997761008607 nudix motif; other site 997761008608 Protein of unknown function (DUF445); Region: DUF445; pfam04286 997761008609 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 997761008610 active site 997761008611 catalytic residues [active] 997761008612 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 997761008613 dimer interface [polypeptide binding]; other site 997761008614 FMN binding site [chemical binding]; other site 997761008615 Domain of unknown function (DUF1904); Region: DUF1904; pfam08921 997761008616 beta-D-glucuronidase; Provisional; Region: PRK10150 997761008617 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 997761008618 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 997761008619 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 997761008620 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761008621 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761008622 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761008623 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 997761008624 putative active site [active] 997761008625 putative metal binding site [ion binding]; other site 997761008626 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 997761008627 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761008628 non-specific DNA binding site [nucleotide binding]; other site 997761008629 salt bridge; other site 997761008630 sequence-specific DNA binding site [nucleotide binding]; other site 997761008631 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528 997761008632 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761008633 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 997761008634 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 997761008635 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 997761008636 Substrate binding site; other site 997761008637 Cupin domain; Region: Cupin_2; cl17218 997761008638 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 997761008639 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 997761008640 NADP-binding site; other site 997761008641 homotetramer interface [polypeptide binding]; other site 997761008642 substrate binding site [chemical binding]; other site 997761008643 homodimer interface [polypeptide binding]; other site 997761008644 active site 997761008645 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 997761008646 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 997761008647 inhibitor-cofactor binding pocket; inhibition site 997761008648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761008649 catalytic residue [active] 997761008650 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 997761008651 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 997761008652 putative trimer interface [polypeptide binding]; other site 997761008653 putative CoA binding site [chemical binding]; other site 997761008654 Domain of unknown function (DUF4386); Region: DUF4386; pfam14329 997761008655 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 997761008656 substrate binding site [chemical binding]; other site 997761008657 active site 997761008658 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 997761008659 dimer interface [polypeptide binding]; other site 997761008660 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761008661 Cupin domain; Region: Cupin_2; pfam07883 997761008662 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761008663 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761008664 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 997761008665 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 997761008666 metal binding site [ion binding]; metal-binding site 997761008667 ligand binding site [chemical binding]; other site 997761008668 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 997761008669 periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038 997761008670 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 997761008671 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 997761008672 protein binding site [polypeptide binding]; other site 997761008673 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761008674 MarR family; Region: MarR; pfam01047 997761008675 Epoxide hydrolase N terminus; Region: EHN; pfam06441 997761008676 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 997761008677 NADH(P)-binding; Region: NAD_binding_10; pfam13460 997761008678 Uncharacterized conserved protein [Function unknown]; Region: COG1262 997761008679 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 997761008680 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 997761008681 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 997761008682 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 997761008683 beta-galactosidase; Region: BGL; TIGR03356 997761008684 hypothetical protein; Provisional; Region: PRK12378 997761008685 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 997761008686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761008687 Coenzyme A binding pocket [chemical binding]; other site 997761008688 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 997761008689 Zn2+ binding site [ion binding]; other site 997761008690 Mg2+ binding site [ion binding]; other site 997761008691 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 997761008692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761008693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761008694 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 997761008695 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 997761008696 active site 997761008697 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 997761008698 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 997761008699 putative metal binding site [ion binding]; other site 997761008700 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 997761008701 putative metal binding site [ion binding]; other site 997761008702 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 997761008703 putative metal binding site [ion binding]; other site 997761008704 Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838 997761008705 putative metal binding site [ion binding]; other site 997761008706 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 997761008707 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761008708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008709 putative PBP binding loops; other site 997761008710 dimer interface [polypeptide binding]; other site 997761008711 ABC-ATPase subunit interface; other site 997761008712 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761008713 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008714 dimer interface [polypeptide binding]; other site 997761008715 conserved gate region; other site 997761008716 putative PBP binding loops; other site 997761008717 ABC-ATPase subunit interface; other site 997761008718 Predicted transcriptional regulator [Transcription]; Region: COG4189 997761008719 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761008720 dimerization interface [polypeptide binding]; other site 997761008721 putative DNA binding site [nucleotide binding]; other site 997761008722 putative Zn2+ binding site [ion binding]; other site 997761008723 beta-D-glucuronidase; Provisional; Region: PRK10150 997761008724 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 997761008725 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 997761008726 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 997761008727 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 997761008728 dimer interface [polypeptide binding]; other site 997761008729 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761008730 RNA polymerase factor sigma-70; Validated; Region: PRK08241 997761008731 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761008732 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761008733 DNA binding residues [nucleotide binding] 997761008734 SnoaL-like domain; Region: SnoaL_2; pfam12680 997761008735 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897 997761008736 putative hydrophobic ligand binding site [chemical binding]; other site 997761008737 DoxX-like family; Region: DoxX_2; pfam13564 997761008738 Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020 997761008739 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761008740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761008741 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 997761008742 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 997761008743 NADP binding site [chemical binding]; other site 997761008744 RibD C-terminal domain; Region: RibD_C; cl17279 997761008745 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 997761008746 Immunity protein Imm6; Region: Imm6; pfam14434 997761008747 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 997761008748 active site 997761008749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761008750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761008751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761008752 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761008753 putative substrate translocation pore; other site 997761008754 Predicted transcriptional regulators [Transcription]; Region: COG1695 997761008755 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 997761008756 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 997761008757 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 997761008758 AAA domain; Region: AAA_18; pfam13238 997761008759 active site 997761008760 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 997761008761 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 997761008762 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761008763 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761008764 amidase; Provisional; Region: PRK06828 997761008765 Amidase; Region: Amidase; cl11426 997761008766 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 997761008767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761008768 Coenzyme A binding pocket [chemical binding]; other site 997761008769 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761008770 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761008771 active site 997761008772 catalytic tetrad [active] 997761008773 Uncharacterized conserved protein [Function unknown]; Region: COG0062 997761008774 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 997761008775 putative substrate binding site [chemical binding]; other site 997761008776 putative ATP binding site [chemical binding]; other site 997761008777 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 997761008778 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 997761008779 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 997761008780 active site 997761008781 DNA binding site [nucleotide binding] 997761008782 Int/Topo IB signature motif; other site 997761008783 peptide synthase; Validated; Region: PRK05691 997761008784 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 997761008785 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761008786 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761008787 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761008788 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 997761008789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008790 dimer interface [polypeptide binding]; other site 997761008791 conserved gate region; other site 997761008792 putative PBP binding loops; other site 997761008793 ABC-ATPase subunit interface; other site 997761008794 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761008795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008796 dimer interface [polypeptide binding]; other site 997761008797 conserved gate region; other site 997761008798 putative PBP binding loops; other site 997761008799 ABC-ATPase subunit interface; other site 997761008800 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 997761008801 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761008802 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 997761008803 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 997761008804 substrate binding site [chemical binding]; other site 997761008805 ATP binding site [chemical binding]; other site 997761008806 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 997761008807 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 997761008808 dimerization interface [polypeptide binding]; other site 997761008809 ligand binding site [chemical binding]; other site 997761008810 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 997761008811 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 997761008812 TM-ABC transporter signature motif; other site 997761008813 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 997761008814 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 997761008815 Walker A/P-loop; other site 997761008816 ATP binding site [chemical binding]; other site 997761008817 Q-loop/lid; other site 997761008818 ABC transporter signature motif; other site 997761008819 Walker B; other site 997761008820 D-loop; other site 997761008821 H-loop/switch region; other site 997761008822 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 997761008823 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 997761008824 Walker A/P-loop; other site 997761008825 ATP binding site [chemical binding]; other site 997761008826 Q-loop/lid; other site 997761008827 ABC transporter signature motif; other site 997761008828 Walker B; other site 997761008829 D-loop; other site 997761008830 H-loop/switch region; other site 997761008831 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761008832 Spore germination protein; Region: Spore_permease; cl17796 997761008833 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761008834 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761008835 Predicted membrane protein [Function unknown]; Region: COG2322 997761008836 Methyltransferase domain; Region: Methyltransf_23; pfam13489 997761008837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761008838 S-adenosylmethionine binding site [chemical binding]; other site 997761008839 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 997761008840 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761008841 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761008842 DNA binding residues [nucleotide binding] 997761008843 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761008844 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 997761008845 Coenzyme A binding pocket [chemical binding]; other site 997761008846 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 997761008847 active site 997761008848 Int/Topo IB signature motif; other site 997761008849 DNA binding site [nucleotide binding] 997761008850 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 997761008851 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 997761008852 active site 997761008853 alpha-glucosidase; Provisional; Region: PRK10426 997761008854 Response regulator receiver domain; Region: Response_reg; pfam00072 997761008855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761008856 active site 997761008857 phosphorylation site [posttranslational modification] 997761008858 intermolecular recognition site; other site 997761008859 dimerization interface [polypeptide binding]; other site 997761008860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761008861 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761008862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761008863 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 997761008864 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761008865 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761008866 dimerization interface [polypeptide binding]; other site 997761008867 Histidine kinase; Region: His_kinase; pfam06580 997761008868 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761008869 ATP binding site [chemical binding]; other site 997761008870 Mg2+ binding site [ion binding]; other site 997761008871 G-X-G motif; other site 997761008872 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761008873 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761008874 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008875 dimer interface [polypeptide binding]; other site 997761008876 conserved gate region; other site 997761008877 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761008878 ABC-ATPase subunit interface; other site 997761008879 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761008880 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008881 dimer interface [polypeptide binding]; other site 997761008882 conserved gate region; other site 997761008883 ABC-ATPase subunit interface; other site 997761008884 Melibiase; Region: Melibiase; pfam02065 997761008885 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 997761008886 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 997761008887 dimerization interface [polypeptide binding]; other site 997761008888 putative ATP binding site [chemical binding]; other site 997761008889 SnoaL-like domain; Region: SnoaL_2; pfam12680 997761008890 short chain dehydrogenase; Provisional; Region: PRK06523 997761008891 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761008892 NAD(P) binding site [chemical binding]; other site 997761008893 active site 997761008894 Predicted transcriptional regulator [Transcription]; Region: COG2378 997761008895 HTH domain; Region: HTH_11; pfam08279 997761008896 WYL domain; Region: WYL; pfam13280 997761008897 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 997761008898 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 997761008899 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 997761008900 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 997761008901 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 997761008902 DNA binding residues [nucleotide binding] 997761008903 putative dimer interface [polypeptide binding]; other site 997761008904 short chain dehydrogenase; Provisional; Region: PRK06500 997761008905 classical (c) SDRs; Region: SDR_c; cd05233 997761008906 NAD(P) binding site [chemical binding]; other site 997761008907 active site 997761008908 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761008909 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761008910 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 997761008911 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 997761008912 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 997761008913 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 997761008914 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 997761008915 sugar binding site [chemical binding]; other site 997761008916 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 997761008917 sugar binding site [chemical binding]; other site 997761008918 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 997761008919 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 997761008920 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 997761008921 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 997761008922 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 997761008923 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 997761008924 putative active site [active] 997761008925 putative metal binding site [ion binding]; other site 997761008926 BNR repeat-like domain; Region: BNR_2; pfam13088 997761008927 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 997761008928 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 997761008929 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 997761008930 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 997761008931 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 997761008932 inhibitor binding site; inhibition site 997761008933 active site 997761008934 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 997761008935 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 997761008936 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 997761008937 putative sugar binding sites [chemical binding]; other site 997761008938 Q-X-W motif; other site 997761008939 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 997761008940 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 997761008941 putative sugar binding sites [chemical binding]; other site 997761008942 Q-X-W motif; other site 997761008943 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 997761008944 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 997761008945 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 997761008946 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 997761008947 ligand binding site [chemical binding]; other site 997761008948 metal binding site [ion binding]; metal-binding site 997761008949 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761008950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008951 dimer interface [polypeptide binding]; other site 997761008952 conserved gate region; other site 997761008953 ABC-ATPase subunit interface; other site 997761008954 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761008955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008956 dimer interface [polypeptide binding]; other site 997761008957 conserved gate region; other site 997761008958 putative PBP binding loops; other site 997761008959 ABC-ATPase subunit interface; other site 997761008960 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761008961 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761008962 Response regulator receiver domain; Region: Response_reg; pfam00072 997761008963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761008964 active site 997761008965 phosphorylation site [posttranslational modification] 997761008966 intermolecular recognition site; other site 997761008967 dimerization interface [polypeptide binding]; other site 997761008968 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761008969 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761008970 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761008971 dimerization interface [polypeptide binding]; other site 997761008972 Histidine kinase; Region: His_kinase; pfam06580 997761008973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761008974 ATP binding site [chemical binding]; other site 997761008975 Mg2+ binding site [ion binding]; other site 997761008976 G-X-G motif; other site 997761008977 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 997761008978 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 997761008979 putative active site [active] 997761008980 putative metal binding site [ion binding]; other site 997761008981 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 997761008982 VPS10 domain; Region: VPS10; smart00602 997761008983 Asp-box motif; other site 997761008984 BNR repeat-like domain; Region: BNR_2; pfam13088 997761008985 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761008986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008987 dimer interface [polypeptide binding]; other site 997761008988 conserved gate region; other site 997761008989 putative PBP binding loops; other site 997761008990 ABC-ATPase subunit interface; other site 997761008991 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761008992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008993 dimer interface [polypeptide binding]; other site 997761008994 ABC-ATPase subunit interface; other site 997761008995 putative PBP binding loops; other site 997761008996 Yip1 domain; Region: Yip1; pfam04893 997761008997 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761008998 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761008999 dimer interface [polypeptide binding]; other site 997761009000 conserved gate region; other site 997761009001 ABC-ATPase subunit interface; other site 997761009002 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761009003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009004 dimer interface [polypeptide binding]; other site 997761009005 conserved gate region; other site 997761009006 putative PBP binding loops; other site 997761009007 ABC-ATPase subunit interface; other site 997761009008 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 997761009009 putative metal binding site [ion binding]; other site 997761009010 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 997761009011 putative metal binding site [ion binding]; other site 997761009012 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009013 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009014 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761009015 Cupin domain; Region: Cupin_2; pfam07883 997761009016 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009017 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761009018 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009019 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 997761009020 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 997761009021 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761009022 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761009023 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761009024 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761009025 putative substrate translocation pore; other site 997761009026 Domain of unknown function (DUF4260); Region: DUF4260; pfam14079 997761009027 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 997761009028 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 997761009029 DNA binding residues [nucleotide binding] 997761009030 dimer interface [polypeptide binding]; other site 997761009031 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 997761009032 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 997761009033 metal-binding site [ion binding] 997761009034 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761009035 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 997761009036 active site 997761009037 metal binding site [ion binding]; metal-binding site 997761009038 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 997761009039 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 997761009040 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 997761009041 putative sugar binding sites [chemical binding]; other site 997761009042 Q-X-W motif; other site 997761009043 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 997761009044 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761009045 active site 997761009046 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761009047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009048 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 997761009049 Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481 997761009050 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 997761009051 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761009052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009053 dimer interface [polypeptide binding]; other site 997761009054 conserved gate region; other site 997761009055 putative PBP binding loops; other site 997761009056 ABC-ATPase subunit interface; other site 997761009057 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761009058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009059 dimer interface [polypeptide binding]; other site 997761009060 conserved gate region; other site 997761009061 ABC-ATPase subunit interface; other site 997761009062 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761009063 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009064 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 997761009065 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 997761009066 Transposase; Region: DEDD_Tnp_IS110; pfam01548 997761009067 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 997761009068 DinB family; Region: DinB; cl17821 997761009069 DinB superfamily; Region: DinB_2; pfam12867 997761009070 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 997761009071 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761009072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 997761009073 Coenzyme A binding pocket [chemical binding]; other site 997761009074 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761009075 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761009076 DinB family; Region: DinB; cl17821 997761009077 DinB superfamily; Region: DinB_2; pfam12867 997761009078 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 997761009079 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761009080 Coenzyme A binding pocket [chemical binding]; other site 997761009081 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 997761009082 ligand-binding site [chemical binding]; other site 997761009083 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 997761009084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761009085 FeS/SAM binding site; other site 997761009086 coproporphyrinogen III oxidase; Validated; Region: PRK08208 997761009087 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761009088 FeS/SAM binding site; other site 997761009089 HemN C-terminal domain; Region: HemN_C; pfam06969 997761009090 Sulfatase; Region: Sulfatase; cl17466 997761009091 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 997761009092 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 997761009093 Substrate binding site [chemical binding]; other site 997761009094 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 997761009095 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 997761009096 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 997761009097 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 997761009098 dipeptidase PepV; Reviewed; Region: PRK07318 997761009099 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 997761009100 active site 997761009101 metal binding site [ion binding]; metal-binding site 997761009102 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 997761009103 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 997761009104 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 997761009105 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761009106 active site 997761009107 SnoaL-like domain; Region: SnoaL_2; pfam12680 997761009108 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 997761009109 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761009110 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761009111 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 997761009112 Predicted transcriptional regulator [Transcription]; Region: COG2378 997761009113 HTH domain; Region: HTH_11; pfam08279 997761009114 WYL domain; Region: WYL; pfam13280 997761009115 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 997761009116 dimer interface [polypeptide binding]; other site 997761009117 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761009118 OsmC-like protein; Region: OsmC; pfam02566 997761009119 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 997761009120 substrate binding site [chemical binding]; other site 997761009121 THF binding site; other site 997761009122 zinc-binding site [ion binding]; other site 997761009123 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 997761009124 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761009125 substrate binding pocket [chemical binding]; other site 997761009126 membrane-bound complex binding site; other site 997761009127 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 997761009128 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 997761009129 active site 997761009130 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761009131 NAD(P) binding site [chemical binding]; other site 997761009132 active site 997761009133 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 997761009134 Ca binding site [ion binding]; other site 997761009135 carbohydrate binding site [chemical binding]; other site 997761009136 Putative esterase; Region: Esterase; pfam00756 997761009137 Response regulator receiver domain; Region: Response_reg; pfam00072 997761009138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761009139 active site 997761009140 phosphorylation site [posttranslational modification] 997761009141 intermolecular recognition site; other site 997761009142 dimerization interface [polypeptide binding]; other site 997761009143 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761009144 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009146 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761009147 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761009148 dimerization interface [polypeptide binding]; other site 997761009149 Histidine kinase; Region: His_kinase; pfam06580 997761009150 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761009151 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009152 dimer interface [polypeptide binding]; other site 997761009153 conserved gate region; other site 997761009154 putative PBP binding loops; other site 997761009155 ABC-ATPase subunit interface; other site 997761009156 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761009157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009158 dimer interface [polypeptide binding]; other site 997761009159 conserved gate region; other site 997761009160 ABC-ATPase subunit interface; other site 997761009161 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009162 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 997761009163 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 997761009164 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 997761009165 putative ligand binding site [chemical binding]; other site 997761009166 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 997761009167 Ca binding site [ion binding]; other site 997761009168 carbohydrate binding site [chemical binding]; other site 997761009169 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761009170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009171 dimer interface [polypeptide binding]; other site 997761009172 conserved gate region; other site 997761009173 ABC-ATPase subunit interface; other site 997761009174 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761009175 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009176 dimer interface [polypeptide binding]; other site 997761009177 conserved gate region; other site 997761009178 ABC-ATPase subunit interface; other site 997761009179 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009180 Response regulator receiver domain; Region: Response_reg; pfam00072 997761009181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761009182 active site 997761009183 phosphorylation site [posttranslational modification] 997761009184 intermolecular recognition site; other site 997761009185 dimerization interface [polypeptide binding]; other site 997761009186 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761009187 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761009188 HAMP domain; Region: HAMP; pfam00672 997761009189 Histidine kinase; Region: His_kinase; pfam06580 997761009190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761009191 ATP binding site [chemical binding]; other site 997761009192 Mg2+ binding site [ion binding]; other site 997761009193 G-X-G motif; other site 997761009194 Response regulator receiver domain; Region: Response_reg; pfam00072 997761009195 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761009196 active site 997761009197 phosphorylation site [posttranslational modification] 997761009198 intermolecular recognition site; other site 997761009199 dimerization interface [polypeptide binding]; other site 997761009200 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761009201 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009202 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009203 Response regulator receiver domain; Region: Response_reg; pfam00072 997761009204 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761009205 active site 997761009206 phosphorylation site [posttranslational modification] 997761009207 intermolecular recognition site; other site 997761009208 dimerization interface [polypeptide binding]; other site 997761009209 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761009210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009211 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009212 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761009213 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761009214 dimerization interface [polypeptide binding]; other site 997761009215 Histidine kinase; Region: His_kinase; pfam06580 997761009216 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761009217 ATP binding site [chemical binding]; other site 997761009218 Mg2+ binding site [ion binding]; other site 997761009219 G-X-G motif; other site 997761009220 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 997761009221 substrate binding site [chemical binding]; other site 997761009222 active site 997761009223 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 997761009224 metal binding site [ion binding]; metal-binding site 997761009225 ligand binding site [chemical binding]; other site 997761009226 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 997761009227 metal binding site [ion binding]; metal-binding site 997761009228 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761009229 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761009230 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 997761009231 dimerization interface [polypeptide binding]; other site 997761009232 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 997761009233 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 997761009234 active site 997761009235 FMN binding site [chemical binding]; other site 997761009236 substrate binding site [chemical binding]; other site 997761009237 putative catalytic residue [active] 997761009238 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 997761009239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009240 dimer interface [polypeptide binding]; other site 997761009241 conserved gate region; other site 997761009242 putative PBP binding loops; other site 997761009243 ABC-ATPase subunit interface; other site 997761009244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009245 dimer interface [polypeptide binding]; other site 997761009246 conserved gate region; other site 997761009247 putative PBP binding loops; other site 997761009248 ABC-ATPase subunit interface; other site 997761009249 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 997761009250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761009251 Walker A/P-loop; other site 997761009252 ATP binding site [chemical binding]; other site 997761009253 Q-loop/lid; other site 997761009254 ABC transporter signature motif; other site 997761009255 Walker B; other site 997761009256 D-loop; other site 997761009257 H-loop/switch region; other site 997761009258 TOBE domain; Region: TOBE_2; pfam08402 997761009259 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 997761009260 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 997761009261 putative hydrolase; Provisional; Region: PRK02113 997761009262 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 997761009263 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 997761009264 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 997761009265 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761009266 DNA-binding site [nucleotide binding]; DNA binding site 997761009267 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 997761009268 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 997761009269 ligand binding site [chemical binding]; other site 997761009270 dimerization interface [polypeptide binding]; other site 997761009271 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761009272 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761009273 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 997761009274 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 997761009275 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009276 Response regulator receiver domain; Region: Response_reg; pfam00072 997761009277 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761009278 active site 997761009279 phosphorylation site [posttranslational modification] 997761009280 intermolecular recognition site; other site 997761009281 dimerization interface [polypeptide binding]; other site 997761009282 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761009283 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009285 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761009286 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761009287 dimerization interface [polypeptide binding]; other site 997761009288 Histidine kinase; Region: His_kinase; pfam06580 997761009289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761009290 ATP binding site [chemical binding]; other site 997761009291 Mg2+ binding site [ion binding]; other site 997761009292 G-X-G motif; other site 997761009293 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009294 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 997761009295 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 997761009296 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 997761009297 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761009298 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009299 dimer interface [polypeptide binding]; other site 997761009300 conserved gate region; other site 997761009301 putative PBP binding loops; other site 997761009302 ABC-ATPase subunit interface; other site 997761009303 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 997761009304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009305 dimer interface [polypeptide binding]; other site 997761009306 conserved gate region; other site 997761009307 putative PBP binding loops; other site 997761009308 ABC-ATPase subunit interface; other site 997761009309 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761009310 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 997761009311 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 997761009312 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 997761009313 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 997761009314 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 997761009315 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 997761009316 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 997761009317 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 997761009318 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 997761009319 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 997761009320 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 997761009321 putative active site [active] 997761009322 putative metal binding site [ion binding]; other site 997761009323 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 997761009324 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761009325 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009326 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761009327 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761009328 putative substrate translocation pore; other site 997761009329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761009330 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 997761009331 calcium mediated ligand binding site; other site 997761009332 intermolecular salt bridges; other site 997761009333 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 997761009334 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 997761009335 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 997761009336 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761009337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009338 dimer interface [polypeptide binding]; other site 997761009339 conserved gate region; other site 997761009340 putative PBP binding loops; other site 997761009341 ABC-ATPase subunit interface; other site 997761009342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009343 dimer interface [polypeptide binding]; other site 997761009344 conserved gate region; other site 997761009345 putative PBP binding loops; other site 997761009346 ABC-ATPase subunit interface; other site 997761009347 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009348 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761009349 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761009350 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009351 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761009352 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761009353 short chain dehydrogenase; Provisional; Region: PRK06924 997761009354 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761009355 NAD(P) binding site [chemical binding]; other site 997761009356 active site 997761009357 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 997761009358 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 997761009359 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 997761009360 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 997761009361 active site pocket [active] 997761009362 oxyanion hole [active] 997761009363 catalytic triad [active] 997761009364 active site nucleophile [active] 997761009365 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 997761009366 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 997761009367 dimer interface [polypeptide binding]; other site 997761009368 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761009369 ligand binding site [chemical binding]; other site 997761009370 Cupin domain; Region: Cupin_2; pfam07883 997761009371 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761009372 MarR family; Region: MarR; pfam01047 997761009373 hypothetical protein; Provisional; Region: PRK08244 997761009374 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 997761009375 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 997761009376 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 997761009377 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009378 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761009379 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 997761009380 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761009381 dimerization interface [polypeptide binding]; other site 997761009382 putative DNA binding site [nucleotide binding]; other site 997761009383 putative Zn2+ binding site [ion binding]; other site 997761009384 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761009385 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761009386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761009387 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 997761009388 putative substrate translocation pore; other site 997761009389 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761009390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761009391 dimerization interface [polypeptide binding]; other site 997761009392 putative DNA binding site [nucleotide binding]; other site 997761009393 putative Zn2+ binding site [ion binding]; other site 997761009394 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 997761009395 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 997761009396 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761009397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009398 dimer interface [polypeptide binding]; other site 997761009399 conserved gate region; other site 997761009400 putative PBP binding loops; other site 997761009401 ABC-ATPase subunit interface; other site 997761009402 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009403 dimer interface [polypeptide binding]; other site 997761009404 conserved gate region; other site 997761009405 putative PBP binding loops; other site 997761009406 ABC-ATPase subunit interface; other site 997761009407 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009408 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761009409 Response regulator receiver domain; Region: Response_reg; pfam00072 997761009410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761009411 active site 997761009412 phosphorylation site [posttranslational modification] 997761009413 intermolecular recognition site; other site 997761009414 dimerization interface [polypeptide binding]; other site 997761009415 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761009416 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009417 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761009418 dimerization interface [polypeptide binding]; other site 997761009419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 997761009420 Histidine kinase; Region: His_kinase; pfam06580 997761009421 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761009422 ATP binding site [chemical binding]; other site 997761009423 Mg2+ binding site [ion binding]; other site 997761009424 G-X-G motif; other site 997761009425 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 997761009426 short chain dehydrogenase; Provisional; Region: PRK08263 997761009427 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 997761009428 NADP binding site [chemical binding]; other site 997761009429 active site 997761009430 steroid binding site; other site 997761009431 Pectate lyase; Region: Pec_lyase_C; cl01593 997761009432 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 997761009433 metal binding site [ion binding]; metal-binding site 997761009434 ligand binding site [chemical binding]; other site 997761009435 Cupin domain; Region: Cupin_2; pfam07883 997761009436 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761009437 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009438 glutamate dehydrogenase; Provisional; Region: PRK09414 997761009439 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 997761009440 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 997761009441 NAD(P) binding site [chemical binding]; other site 997761009442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761009443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761009444 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 997761009445 putative dimerization interface [polypeptide binding]; other site 997761009446 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 997761009447 [2Fe-2S] cluster binding site [ion binding]; other site 997761009448 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 997761009449 This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511 997761009450 putative di-iron ligands [ion binding]; other site 997761009451 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 997761009452 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 997761009453 AP (apurinic/apyrimidinic) site pocket; other site 997761009454 DNA interaction; other site 997761009455 Metal-binding active site; metal-binding site 997761009456 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761009457 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761009458 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761009459 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 997761009460 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 997761009461 inhibitor binding site; inhibition site 997761009462 active site 997761009463 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009464 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761009465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009466 dimer interface [polypeptide binding]; other site 997761009467 conserved gate region; other site 997761009468 putative PBP binding loops; other site 997761009469 ABC-ATPase subunit interface; other site 997761009470 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761009471 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 997761009472 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 997761009473 Helix-turn-helix domain; Region: HTH_18; pfam12833 997761009474 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009475 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761009476 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761009477 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 997761009478 active site 2 [active] 997761009479 active site 1 [active] 997761009480 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 997761009481 Amidohydrolase; Region: Amidohydro_2; pfam04909 997761009482 active site 997761009483 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 997761009484 CoA-transferase family III; Region: CoA_transf_3; pfam02515 997761009485 Transcriptional regulators [Transcription]; Region: FadR; COG2186 997761009486 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761009487 DNA-binding site [nucleotide binding]; DNA binding site 997761009488 FCD domain; Region: FCD; pfam07729 997761009489 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 997761009490 EamA-like transporter family; Region: EamA; pfam00892 997761009491 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 997761009492 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761009493 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761009494 putative DNA binding site [nucleotide binding]; other site 997761009495 putative Zn2+ binding site [ion binding]; other site 997761009496 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 997761009497 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 997761009498 metal ion-dependent adhesion site (MIDAS); other site 997761009499 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 997761009500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761009501 salt bridge; other site 997761009502 non-specific DNA binding site [nucleotide binding]; other site 997761009503 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 997761009504 sequence-specific DNA binding site [nucleotide binding]; other site 997761009505 PAS domain; Region: PAS; smart00091 997761009506 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 997761009507 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 997761009508 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 997761009509 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761009510 motif II; other site 997761009511 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 997761009512 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 997761009513 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761009514 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761009515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009516 dimer interface [polypeptide binding]; other site 997761009517 conserved gate region; other site 997761009518 putative PBP binding loops; other site 997761009519 ABC-ATPase subunit interface; other site 997761009520 maltodextrin glucosidase; Provisional; Region: PRK10785 997761009521 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 997761009522 homodimer interface [polypeptide binding]; other site 997761009523 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 997761009524 active site 997761009525 homodimer interface [polypeptide binding]; other site 997761009526 catalytic site [active] 997761009527 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 997761009528 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 997761009529 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 997761009530 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761009531 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761009532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761009533 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761009534 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 997761009535 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 997761009536 active site 997761009537 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 997761009538 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 997761009539 dimer interface [polypeptide binding]; other site 997761009540 active site 997761009541 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761009542 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 997761009543 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 997761009544 NAD(P) binding site [chemical binding]; other site 997761009545 homotetramer interface [polypeptide binding]; other site 997761009546 homodimer interface [polypeptide binding]; other site 997761009547 active site 997761009548 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 997761009549 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 997761009550 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 997761009551 Methylamine utilisation protein MauE; Region: MauE; pfam07291 997761009552 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 997761009553 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 997761009554 active site 997761009555 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 997761009556 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 997761009557 beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955 997761009558 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 997761009559 putative NADP binding site [chemical binding]; other site 997761009560 active site 997761009561 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 997761009562 Thioesterase domain; Region: Thioesterase; pfam00975 997761009563 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 997761009564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761009565 H+ Antiporter protein; Region: 2A0121; TIGR00900 997761009566 putative substrate translocation pore; other site 997761009567 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761009568 DNA binding residues [nucleotide binding] 997761009569 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 997761009570 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 997761009571 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 997761009572 trimer interface [polypeptide binding]; other site 997761009573 active site 997761009574 substrate binding site [chemical binding]; other site 997761009575 CoA binding site [chemical binding]; other site 997761009576 Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057 997761009577 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 997761009578 TrkA-N domain; Region: TrkA_N; pfam02254 997761009579 TrkA-C domain; Region: TrkA_C; pfam02080 997761009580 Helix-turn-helix domain; Region: HTH_28; pfam13518 997761009581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 997761009582 Transposase; Region: HTH_Tnp_1; cl17663 997761009583 Helix-turn-helix domain; Region: HTH_28; pfam13518 997761009584 OsmC-like protein; Region: OsmC; pfam02566 997761009585 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009586 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 997761009587 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761009588 Ferredoxin [Energy production and conversion]; Region: COG1146 997761009589 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 997761009590 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 997761009591 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 997761009592 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 997761009593 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 997761009594 active site 997761009595 non-prolyl cis peptide bond; other site 997761009596 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 997761009597 dimer interface [polypeptide binding]; other site 997761009598 FMN binding site [chemical binding]; other site 997761009599 NADPH bind site [chemical binding]; other site 997761009600 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 997761009601 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 997761009602 active site 997761009603 non-prolyl cis peptide bond; other site 997761009604 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761009605 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761009606 active site 997761009607 catalytic tetrad [active] 997761009608 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009609 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 997761009610 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 997761009611 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 997761009612 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 997761009613 active site 997761009614 non-prolyl cis peptide bond; other site 997761009615 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 997761009616 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 997761009617 active site 997761009618 non-prolyl cis peptide bond; other site 997761009619 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 997761009620 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761009621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761009622 Walker A/P-loop; other site 997761009623 ATP binding site [chemical binding]; other site 997761009624 Q-loop/lid; other site 997761009625 ABC transporter signature motif; other site 997761009626 Walker B; other site 997761009627 D-loop; other site 997761009628 H-loop/switch region; other site 997761009629 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009630 ABC-ATPase subunit interface; other site 997761009631 putative PBP binding loops; other site 997761009632 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 997761009633 NHL repeat; Region: NHL; pfam01436 997761009634 NHL repeat; Region: NHL; pfam01436 997761009635 Tetratricopeptide repeat; Region: TPR_16; pfam13432 997761009636 Yip1 domain; Region: Yip1; cl17815 997761009637 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761009638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009639 dimer interface [polypeptide binding]; other site 997761009640 conserved gate region; other site 997761009641 putative PBP binding loops; other site 997761009642 ABC-ATPase subunit interface; other site 997761009643 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761009644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009645 dimer interface [polypeptide binding]; other site 997761009646 conserved gate region; other site 997761009647 putative PBP binding loops; other site 997761009648 ABC-ATPase subunit interface; other site 997761009649 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 997761009650 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 997761009651 Walker A/P-loop; other site 997761009652 ATP binding site [chemical binding]; other site 997761009653 Q-loop/lid; other site 997761009654 ABC transporter signature motif; other site 997761009655 Walker B; other site 997761009656 D-loop; other site 997761009657 H-loop/switch region; other site 997761009658 TOBE domain; Region: TOBE_2; pfam08402 997761009659 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 997761009660 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 997761009661 Cysteine-rich domain; Region: CCG; pfam02754 997761009662 Cysteine-rich domain; Region: CCG; pfam02754 997761009663 FAD binding domain; Region: FAD_binding_4; pfam01565 997761009664 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 997761009665 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761009666 salt bridge; other site 997761009667 non-specific DNA binding site [nucleotide binding]; other site 997761009668 sequence-specific DNA binding site [nucleotide binding]; other site 997761009669 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 997761009670 Predicted membrane protein [Function unknown]; Region: COG2311 997761009671 Protein of unknown function (DUF418); Region: DUF418; pfam04235 997761009672 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 997761009673 putative catalytic site [active] 997761009674 putative metal binding site [ion binding]; other site 997761009675 putative phosphate binding site [ion binding]; other site 997761009676 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 997761009677 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761009678 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761009679 putative substrate translocation pore; other site 997761009680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761009681 Helix-turn-helix domain; Region: HTH_31; pfam13560 997761009682 salt bridge; other site 997761009683 non-specific DNA binding site [nucleotide binding]; other site 997761009684 sequence-specific DNA binding site [nucleotide binding]; other site 997761009685 DinB family; Region: DinB; cl17821 997761009686 DinB superfamily; Region: DinB_2; pfam12867 997761009687 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761009688 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761009689 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 997761009690 dimerization interface [polypeptide binding]; other site 997761009691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761009692 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761009693 putative substrate translocation pore; other site 997761009694 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761009695 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 997761009696 RibD C-terminal domain; Region: RibD_C; cl17279 997761009697 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761009698 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 997761009699 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761009700 putative DNA binding site [nucleotide binding]; other site 997761009701 putative Zn2+ binding site [ion binding]; other site 997761009702 AsnC family; Region: AsnC_trans_reg; pfam01037 997761009703 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 997761009704 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 997761009705 putative NAD(P) binding site [chemical binding]; other site 997761009706 putative substrate binding site [chemical binding]; other site 997761009707 catalytic Zn binding site [ion binding]; other site 997761009708 structural Zn binding site [ion binding]; other site 997761009709 dimer interface [polypeptide binding]; other site 997761009710 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 997761009711 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 997761009712 dimer interface [polypeptide binding]; other site 997761009713 PYR/PP interface [polypeptide binding]; other site 997761009714 TPP binding site [chemical binding]; other site 997761009715 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 997761009716 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 997761009717 TPP-binding site [chemical binding]; other site 997761009718 dimer interface [polypeptide binding]; other site 997761009719 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 997761009720 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 997761009721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761009722 HAMP domain; Region: HAMP; pfam00672 997761009723 dimerization interface [polypeptide binding]; other site 997761009724 Histidine kinase; Region: His_kinase; pfam06580 997761009725 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761009726 ATP binding site [chemical binding]; other site 997761009727 Mg2+ binding site [ion binding]; other site 997761009728 G-X-G motif; other site 997761009729 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009730 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761009731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009732 dimer interface [polypeptide binding]; other site 997761009733 conserved gate region; other site 997761009734 putative PBP binding loops; other site 997761009735 ABC-ATPase subunit interface; other site 997761009736 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761009737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009738 dimer interface [polypeptide binding]; other site 997761009739 conserved gate region; other site 997761009740 ABC-ATPase subunit interface; other site 997761009741 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 997761009742 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761009743 active site 997761009744 phosphorylation site [posttranslational modification] 997761009745 intermolecular recognition site; other site 997761009746 dimerization interface [polypeptide binding]; other site 997761009747 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009748 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 997761009749 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761009750 DNA-binding site [nucleotide binding]; DNA binding site 997761009751 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761009752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761009753 homodimer interface [polypeptide binding]; other site 997761009754 catalytic residue [active] 997761009755 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 997761009756 dimer interface [polypeptide binding]; other site 997761009757 FMN binding site [chemical binding]; other site 997761009758 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 997761009759 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 997761009760 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 997761009761 putative active site [active] 997761009762 putative metal binding site [ion binding]; other site 997761009763 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 997761009764 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 997761009765 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 997761009766 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 997761009767 Ca binding site [ion binding]; other site 997761009768 carbohydrate binding site [chemical binding]; other site 997761009769 S-layer homology domain; Region: SLH; pfam00395 997761009770 S-layer homology domain; Region: SLH; pfam00395 997761009771 S-layer homology domain; Region: SLH; pfam00395 997761009772 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 997761009773 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 997761009774 NAD(P) binding site [chemical binding]; other site 997761009775 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761009776 S-adenosylmethionine binding site [chemical binding]; other site 997761009777 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 997761009778 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 997761009779 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 997761009780 HlyD family secretion protein; Region: HlyD_3; pfam13437 997761009781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761009782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 997761009783 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009784 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 997761009785 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761009786 dimerization interface [polypeptide binding]; other site 997761009787 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761009788 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761009789 dimer interface [polypeptide binding]; other site 997761009790 putative CheW interface [polypeptide binding]; other site 997761009791 Cache domain; Region: Cache_1; pfam02743 997761009792 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 997761009793 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761009794 dimerization interface [polypeptide binding]; other site 997761009795 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761009796 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761009797 metal binding site [ion binding]; metal-binding site 997761009798 active site 997761009799 I-site; other site 997761009800 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 997761009801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009802 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761009803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009804 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 997761009805 Condensation domain; Region: Condensation; pfam00668 997761009806 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 997761009807 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 997761009808 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 997761009809 acyl-activating enzyme (AAE) consensus motif; other site 997761009810 AMP binding site [chemical binding]; other site 997761009811 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761009812 Condensation domain; Region: Condensation; pfam00668 997761009813 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 997761009814 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 997761009815 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 997761009816 active site 997761009817 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761009818 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 997761009819 conserved cys residue [active] 997761009820 Putative amidotransferase; Region: DUF4066; pfam13278 997761009821 Predicted transcriptional regulators [Transcription]; Region: COG1695 997761009822 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 997761009823 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 997761009824 Lipase (class 2); Region: Lipase_2; pfam01674 997761009825 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761009826 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761009827 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 997761009828 NAD(P) binding site [chemical binding]; other site 997761009829 active site 997761009830 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 997761009831 active site 997761009832 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 997761009833 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 997761009834 phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315 997761009835 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 997761009836 Walker A/P-loop; other site 997761009837 ATP binding site [chemical binding]; other site 997761009838 Q-loop/lid; other site 997761009839 ABC transporter signature motif; other site 997761009840 Walker B; other site 997761009841 D-loop; other site 997761009842 H-loop/switch region; other site 997761009843 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 997761009844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761009845 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 997761009846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009847 dimer interface [polypeptide binding]; other site 997761009848 conserved gate region; other site 997761009849 ABC-ATPase subunit interface; other site 997761009850 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 997761009851 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761009852 substrate binding pocket [chemical binding]; other site 997761009853 membrane-bound complex binding site; other site 997761009854 hinge residues; other site 997761009855 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761009856 Transcriptional regulators [Transcription]; Region: FadR; COG2186 997761009857 DNA-binding site [nucleotide binding]; DNA binding site 997761009858 FCD domain; Region: FCD; pfam07729 997761009859 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 997761009860 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 997761009861 Predicted permeases [General function prediction only]; Region: RarD; COG2962 997761009862 EamA-like transporter family; Region: EamA; pfam00892 997761009863 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761009864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009865 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009866 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761009867 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761009868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009869 ABC-ATPase subunit interface; other site 997761009870 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761009871 Interdomain contacts; other site 997761009872 Cytokine receptor motif; other site 997761009873 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761009874 Interdomain contacts; other site 997761009875 Cytokine receptor motif; other site 997761009876 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761009877 Interdomain contacts; other site 997761009878 Cytokine receptor motif; other site 997761009879 putative pectinesterase; Region: PLN02432; cl01911 997761009880 Pectinesterase; Region: Pectinesterase; pfam01095 997761009881 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761009882 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761009883 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009884 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009885 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761009886 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761009887 active site 997761009888 catalytic tetrad [active] 997761009889 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761009890 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761009891 DNA binding site [nucleotide binding] 997761009892 domain linker motif; other site 997761009893 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 997761009894 dimerization interface [polypeptide binding]; other site 997761009895 ligand binding site [chemical binding]; other site 997761009896 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 997761009897 classical (c) SDRs; Region: SDR_c; cd05233 997761009898 NAD(P) binding site [chemical binding]; other site 997761009899 active site 997761009900 Cytochrome P450; Region: p450; cl12078 997761009901 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 997761009902 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761009903 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761009904 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 997761009905 Major royal jelly protein; Region: MRJP; pfam03022 997761009906 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 997761009907 dimer interface [polypeptide binding]; other site 997761009908 FMN binding site [chemical binding]; other site 997761009909 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 997761009910 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 997761009911 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 997761009912 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 997761009913 Cellulose binding domain; Region: CBM_3; pfam00942 997761009914 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 997761009915 substrate binding site [chemical binding]; other site 997761009916 active site 997761009917 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 997761009918 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 997761009919 putative sugar binding sites [chemical binding]; other site 997761009920 Q-X-W motif; other site 997761009921 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761009922 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761009923 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761009924 dimerization interface [polypeptide binding]; other site 997761009925 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 997761009926 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 997761009927 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761009928 putative substrate translocation pore; other site 997761009929 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 997761009930 active site 997761009931 catalytic triad [active] 997761009932 oxyanion hole [active] 997761009933 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 997761009934 Putative esterase; Region: Esterase; pfam00756 997761009935 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 997761009936 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761009937 ABC-ATPase subunit interface; other site 997761009938 dimer interface [polypeptide binding]; other site 997761009939 putative PBP binding regions; other site 997761009940 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 997761009941 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 997761009942 intersubunit interface [polypeptide binding]; other site 997761009943 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761009944 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761009945 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 997761009946 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 997761009947 intersubunit interface [polypeptide binding]; other site 997761009948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761009949 active site 997761009950 Amb_all domain; Region: Amb_all; smart00656 997761009951 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 997761009952 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761009953 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 997761009954 Walker A/P-loop; other site 997761009955 ATP binding site [chemical binding]; other site 997761009956 Q-loop/lid; other site 997761009957 ABC transporter signature motif; other site 997761009958 Walker B; other site 997761009959 D-loop; other site 997761009960 H-loop/switch region; other site 997761009961 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 997761009962 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761009963 putative substrate translocation pore; other site 997761009964 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761009965 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761009966 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 997761009967 putative dimerization interface [polypeptide binding]; other site 997761009968 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 997761009969 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 997761009970 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 997761009971 active site 997761009972 non-prolyl cis peptide bond; other site 997761009973 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761009974 substrate binding pocket [chemical binding]; other site 997761009975 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 997761009976 membrane-bound complex binding site; other site 997761009977 hinge residues; other site 997761009978 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 997761009979 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 997761009980 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761009981 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761009982 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761009983 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761009984 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761009985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009986 dimer interface [polypeptide binding]; other site 997761009987 conserved gate region; other site 997761009988 ABC-ATPase subunit interface; other site 997761009989 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761009990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761009991 dimer interface [polypeptide binding]; other site 997761009992 conserved gate region; other site 997761009993 ABC-ATPase subunit interface; other site 997761009994 Response regulator receiver domain; Region: Response_reg; pfam00072 997761009995 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761009996 active site 997761009997 phosphorylation site [posttranslational modification] 997761009998 intermolecular recognition site; other site 997761009999 dimerization interface [polypeptide binding]; other site 997761010000 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010001 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761010002 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010003 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761010004 dimerization interface [polypeptide binding]; other site 997761010005 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761010006 Histidine kinase; Region: His_kinase; pfam06580 997761010007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761010008 ATP binding site [chemical binding]; other site 997761010009 Mg2+ binding site [ion binding]; other site 997761010010 G-X-G motif; other site 997761010011 Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790 997761010012 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 997761010013 Melibiase; Region: Melibiase; pfam02065 997761010014 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761010015 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761010016 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010017 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010018 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 997761010019 putative metal binding site [ion binding]; other site 997761010020 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 997761010021 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761010022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761010023 putative substrate translocation pore; other site 997761010024 Uncharacterized conserved protein [Function unknown]; Region: COG0397 997761010025 hypothetical protein; Validated; Region: PRK00029 997761010026 Pectate lyase; Region: Pec_lyase_C; cl01593 997761010027 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761010028 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761010029 putative substrate translocation pore; other site 997761010030 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 997761010031 FAD binding domain; Region: FAD_binding_4; pfam01565 997761010032 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761010033 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 997761010034 putative hydrophobic ligand binding site [chemical binding]; other site 997761010035 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 997761010036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 997761010037 Predicted transcriptional regulator [Transcription]; Region: COG1959 997761010038 Transcriptional regulator; Region: Rrf2; pfam02082 997761010039 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761010040 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761010041 dimerization interface [polypeptide binding]; other site 997761010042 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761010043 dimer interface [polypeptide binding]; other site 997761010044 phosphorylation site [posttranslational modification] 997761010045 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761010046 ATP binding site [chemical binding]; other site 997761010047 Mg2+ binding site [ion binding]; other site 997761010048 G-X-G motif; other site 997761010049 Response regulator receiver domain; Region: Response_reg; pfam00072 997761010050 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761010051 active site 997761010052 phosphorylation site [posttranslational modification] 997761010053 intermolecular recognition site; other site 997761010054 dimerization interface [polypeptide binding]; other site 997761010055 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761010056 FOG: CBS domain [General function prediction only]; Region: COG0517 997761010057 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 997761010058 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761010059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761010060 active site 997761010061 phosphorylation site [posttranslational modification] 997761010062 intermolecular recognition site; other site 997761010063 dimerization interface [polypeptide binding]; other site 997761010064 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761010065 DNA binding site [nucleotide binding] 997761010066 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761010067 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761010068 dimerization interface [polypeptide binding]; other site 997761010069 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761010070 dimer interface [polypeptide binding]; other site 997761010071 phosphorylation site [posttranslational modification] 997761010072 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761010073 ATP binding site [chemical binding]; other site 997761010074 Mg2+ binding site [ion binding]; other site 997761010075 G-X-G motif; other site 997761010076 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761010077 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 997761010078 Walker A/P-loop; other site 997761010079 ATP binding site [chemical binding]; other site 997761010080 Q-loop/lid; other site 997761010081 ABC transporter signature motif; other site 997761010082 Walker B; other site 997761010083 D-loop; other site 997761010084 H-loop/switch region; other site 997761010085 L-fucose isomerase; Provisional; Region: fucI; PRK10991 997761010086 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 997761010087 hexamer (dimer of trimers) interface [polypeptide binding]; other site 997761010088 trimer interface [polypeptide binding]; other site 997761010089 substrate binding site [chemical binding]; other site 997761010090 Mn binding site [ion binding]; other site 997761010091 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 997761010092 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 997761010093 inhibitor site; inhibition site 997761010094 active site 997761010095 dimer interface [polypeptide binding]; other site 997761010096 catalytic residue [active] 997761010097 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761010098 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761010099 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761010100 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761010101 Interdomain contacts; other site 997761010102 Cytokine receptor motif; other site 997761010103 putative pectinesterase; Region: PLN02432; cl01911 997761010104 Pectinesterase; Region: Pectinesterase; pfam01095 997761010105 Pectate lyase; Region: Pec_lyase_C; cl01593 997761010106 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177 997761010107 Abhydrolase family; Region: Abhydrolase_7; pfam12715 997761010108 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761010109 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761010110 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761010111 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 997761010112 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 997761010113 Walker A/P-loop; other site 997761010114 ATP binding site [chemical binding]; other site 997761010115 Q-loop/lid; other site 997761010116 ABC transporter signature motif; other site 997761010117 Walker B; other site 997761010118 D-loop; other site 997761010119 H-loop/switch region; other site 997761010120 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 997761010121 FtsX-like permease family; Region: FtsX; pfam02687 997761010122 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 997761010123 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 997761010124 HlyD family secretion protein; Region: HlyD_3; pfam13437 997761010125 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 997761010126 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 997761010127 Walker A/P-loop; other site 997761010128 ATP binding site [chemical binding]; other site 997761010129 Q-loop/lid; other site 997761010130 ABC transporter signature motif; other site 997761010131 Walker B; other site 997761010132 D-loop; other site 997761010133 H-loop/switch region; other site 997761010134 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 997761010135 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 997761010136 DNA binding residues [nucleotide binding] 997761010137 dimer interface [polypeptide binding]; other site 997761010138 S-layer homology domain; Region: SLH; pfam00395 997761010139 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761010140 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761010141 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761010142 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761010143 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761010144 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010145 dimer interface [polypeptide binding]; other site 997761010146 conserved gate region; other site 997761010147 putative PBP binding loops; other site 997761010148 ABC-ATPase subunit interface; other site 997761010149 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761010150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010151 ABC-ATPase subunit interface; other site 997761010152 NHL repeat; Region: NHL; pfam01436 997761010153 Yip1 domain; Region: Yip1; pfam04893 997761010154 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 997761010155 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 997761010156 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 997761010157 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 997761010158 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 997761010159 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761010160 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761010161 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761010162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761010163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010164 dimer interface [polypeptide binding]; other site 997761010165 conserved gate region; other site 997761010166 ABC-ATPase subunit interface; other site 997761010167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010168 dimer interface [polypeptide binding]; other site 997761010169 conserved gate region; other site 997761010170 putative PBP binding loops; other site 997761010171 ABC-ATPase subunit interface; other site 997761010172 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 997761010173 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 997761010174 putative metal binding site [ion binding]; other site 997761010175 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761010176 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761010177 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 997761010178 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 997761010179 Walker A/P-loop; other site 997761010180 ATP binding site [chemical binding]; other site 997761010181 Q-loop/lid; other site 997761010182 ABC transporter signature motif; other site 997761010183 Walker B; other site 997761010184 D-loop; other site 997761010185 H-loop/switch region; other site 997761010186 Abhydrolase family; Region: Abhydrolase_7; pfam12715 997761010187 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 997761010188 BNR repeat-like domain; Region: BNR_2; pfam13088 997761010189 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 997761010190 BNR repeat-like domain; Region: BNR_2; pfam13088 997761010191 Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120 997761010192 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 997761010193 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 997761010194 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 997761010195 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 997761010196 active site 997761010197 catalytic triad [active] 997761010198 oxyanion hole [active] 997761010199 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 997761010200 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 997761010201 inhibitor site; inhibition site 997761010202 active site 997761010203 dimer interface [polypeptide binding]; other site 997761010204 catalytic residue [active] 997761010205 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 997761010206 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 997761010207 putative active site [active] 997761010208 metal binding site [ion binding]; metal-binding site 997761010209 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 997761010210 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 997761010211 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 997761010212 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 997761010213 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 997761010214 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761010215 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010216 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 997761010217 ABC-ATPase subunit interface; other site 997761010218 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761010219 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761010220 dimerization interface [polypeptide binding]; other site 997761010221 Histidine kinase; Region: His_kinase; pfam06580 997761010222 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761010223 ATP binding site [chemical binding]; other site 997761010224 Mg2+ binding site [ion binding]; other site 997761010225 G-X-G motif; other site 997761010226 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761010227 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 997761010228 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 997761010229 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761010230 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761010231 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761010232 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 997761010233 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761010234 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761010235 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 997761010236 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 997761010237 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 997761010238 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 997761010239 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 997761010240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 997761010241 Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207 997761010242 Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850 997761010243 dimer interface [polypeptide binding]; other site 997761010244 active site 997761010245 catalytic residue [active] 997761010246 metal binding site [ion binding]; metal-binding site 997761010247 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 997761010248 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 997761010249 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 997761010250 active site 997761010251 intersubunit interface [polypeptide binding]; other site 997761010252 catalytic residue [active] 997761010253 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 997761010254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761010255 NAD(P) binding site [chemical binding]; other site 997761010256 active site 997761010257 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 997761010258 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 997761010259 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 997761010260 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761010261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010262 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 997761010263 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 997761010264 N- and C-terminal domain interface [polypeptide binding]; other site 997761010265 active site 997761010266 MgATP binding site [chemical binding]; other site 997761010267 catalytic site [active] 997761010268 metal binding site [ion binding]; metal-binding site 997761010269 glycerol binding site [chemical binding]; other site 997761010270 homotetramer interface [polypeptide binding]; other site 997761010271 homodimer interface [polypeptide binding]; other site 997761010272 FBP binding site [chemical binding]; other site 997761010273 protein IIAGlc interface [polypeptide binding]; other site 997761010274 transketolase; Reviewed; Region: PRK05899 997761010275 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 997761010276 TPP-binding site [chemical binding]; other site 997761010277 dimer interface [polypeptide binding]; other site 997761010278 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 997761010279 hexamer (dimer of trimers) interface [polypeptide binding]; other site 997761010280 substrate binding site [chemical binding]; other site 997761010281 trimer interface [polypeptide binding]; other site 997761010282 Mn binding site [ion binding]; other site 997761010283 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761010284 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761010285 DNA binding site [nucleotide binding] 997761010286 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 997761010287 ligand binding site [chemical binding]; other site 997761010288 dimerization interface [polypeptide binding]; other site 997761010289 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 997761010290 conserved cys residue [active] 997761010291 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 997761010292 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 997761010293 Spore germination protein; Region: Spore_permease; cl17796 997761010294 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761010295 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761010296 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761010297 Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341 997761010298 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 997761010299 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 997761010300 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 997761010301 DoxX-like family; Region: DoxX_2; pfam13564 997761010302 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 997761010303 ADP-ribose binding site [chemical binding]; other site 997761010304 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 997761010305 MutS domain III; Region: MutS_III; pfam05192 997761010306 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761010307 Walker A/P-loop; other site 997761010308 ATP binding site [chemical binding]; other site 997761010309 Q-loop/lid; other site 997761010310 ABC transporter signature motif; other site 997761010311 Walker B; other site 997761010312 D-loop; other site 997761010313 H-loop/switch region; other site 997761010314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761010315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761010316 active site 997761010317 phosphorylation site [posttranslational modification] 997761010318 intermolecular recognition site; other site 997761010319 dimerization interface [polypeptide binding]; other site 997761010320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761010321 DNA binding site [nucleotide binding] 997761010322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761010323 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761010324 dimerization interface [polypeptide binding]; other site 997761010325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761010326 dimer interface [polypeptide binding]; other site 997761010327 phosphorylation site [posttranslational modification] 997761010328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761010329 ATP binding site [chemical binding]; other site 997761010330 Mg2+ binding site [ion binding]; other site 997761010331 G-X-G motif; other site 997761010332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761010333 putative substrate translocation pore; other site 997761010334 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 997761010335 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 997761010336 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761010337 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 997761010338 dimer interface [polypeptide binding]; other site 997761010339 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 997761010340 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 997761010341 putative NAD(P) binding site [chemical binding]; other site 997761010342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761010343 putative substrate translocation pore; other site 997761010344 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761010345 DNA binding domain, excisionase family; Region: excise; TIGR01764 997761010346 PBP superfamily domain; Region: PBP_like; pfam12727 997761010347 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 997761010348 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010349 dimer interface [polypeptide binding]; other site 997761010350 ABC-ATPase subunit interface; other site 997761010351 putative PBP binding loops; other site 997761010352 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 997761010353 Fibrobacter succinogenes paralogous family TIGR02172; Region: Fb_sc_TIGR02172 997761010354 active site 997761010355 substrate binding site [chemical binding]; other site 997761010356 ATP binding site [chemical binding]; other site 997761010357 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 997761010358 active site 997761010359 oxyanion hole [active] 997761010360 Uncharacterized conserved protein [Function unknown]; Region: COG1262 997761010361 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 997761010362 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761010363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010364 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761010365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010366 dimer interface [polypeptide binding]; other site 997761010367 conserved gate region; other site 997761010368 putative PBP binding loops; other site 997761010369 ABC-ATPase subunit interface; other site 997761010370 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761010371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010372 ABC-ATPase subunit interface; other site 997761010373 Domain of unknown function (DUF303); Region: DUF303; pfam03629 997761010374 Peptidase family C69; Region: Peptidase_C69; cl17793 997761010375 Phophatidylserine decarboxylase; Region: PSDC; pfam12588 997761010376 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; pfam02666 997761010377 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761010378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761010379 active site 997761010380 phosphorylation site [posttranslational modification] 997761010381 intermolecular recognition site; other site 997761010382 dimerization interface [polypeptide binding]; other site 997761010383 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761010384 DNA binding site [nucleotide binding] 997761010385 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761010386 dimerization interface [polypeptide binding]; other site 997761010387 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761010388 dimer interface [polypeptide binding]; other site 997761010389 phosphorylation site [posttranslational modification] 997761010390 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761010391 ATP binding site [chemical binding]; other site 997761010392 Mg2+ binding site [ion binding]; other site 997761010393 G-X-G motif; other site 997761010394 H+ Antiporter protein; Region: 2A0121; TIGR00900 997761010395 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761010396 putative substrate translocation pore; other site 997761010397 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 997761010398 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 997761010399 THF binding site; other site 997761010400 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 997761010401 substrate binding site [chemical binding]; other site 997761010402 THF binding site; other site 997761010403 zinc-binding site [ion binding]; other site 997761010404 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761010405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761010406 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761010407 dimerization interface [polypeptide binding]; other site 997761010408 Helix-turn-helix domain; Region: HTH_18; pfam12833 997761010409 putative pectinesterase; Region: PLN02432; cl01911 997761010410 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 997761010411 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 997761010412 metal binding site [ion binding]; metal-binding site 997761010413 Family description; Region: VCBS; pfam13517 997761010414 active site 997761010415 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761010416 Interdomain contacts; other site 997761010417 Cytokine receptor motif; other site 997761010418 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761010419 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 997761010420 active site 997761010421 metal binding site [ion binding]; metal-binding site 997761010422 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761010423 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761010424 active site 997761010425 catalytic tetrad [active] 997761010426 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 997761010427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761010428 DNA-binding site [nucleotide binding]; DNA binding site 997761010429 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761010430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761010431 homodimer interface [polypeptide binding]; other site 997761010432 catalytic residue [active] 997761010433 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 997761010434 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 997761010435 Condensation domain; Region: Condensation; pfam00668 997761010436 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 997761010437 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 997761010438 acyl-activating enzyme (AAE) consensus motif; other site 997761010439 AMP binding site [chemical binding]; other site 997761010440 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761010441 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 997761010442 Condensation domain; Region: Condensation; pfam00668 997761010443 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 997761010444 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 997761010445 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 997761010446 acyl-activating enzyme (AAE) consensus motif; other site 997761010447 AMP binding site [chemical binding]; other site 997761010448 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761010449 Condensation domain; Region: Condensation; pfam00668 997761010450 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 997761010451 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 997761010452 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 997761010453 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 997761010454 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 997761010455 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 997761010456 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 997761010457 active site 997761010458 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 997761010459 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 997761010460 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 997761010461 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 997761010462 putative NADP binding site [chemical binding]; other site 997761010463 active site 997761010464 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761010465 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761010466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010467 dimer interface [polypeptide binding]; other site 997761010468 conserved gate region; other site 997761010469 putative PBP binding loops; other site 997761010470 ABC-ATPase subunit interface; other site 997761010471 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761010472 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761010473 Histidine kinase; Region: His_kinase; pfam06580 997761010474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761010475 ATP binding site [chemical binding]; other site 997761010476 Mg2+ binding site [ion binding]; other site 997761010477 G-X-G motif; other site 997761010478 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761010479 Response regulator receiver domain; Region: Response_reg; pfam00072 997761010480 active site 997761010481 phosphorylation site [posttranslational modification] 997761010482 intermolecular recognition site; other site 997761010483 dimerization interface [polypeptide binding]; other site 997761010484 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761010485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010486 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 997761010487 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 997761010488 DNA binding residues [nucleotide binding] 997761010489 dimer interface [polypeptide binding]; other site 997761010490 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 997761010491 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 997761010492 dimer interface [polypeptide binding]; other site 997761010493 active site 997761010494 catalytic residue [active] 997761010495 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761010496 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761010497 haloalkane dehalogenase; Provisional; Region: PRK03204 997761010498 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 997761010499 RibD C-terminal domain; Region: RibD_C; cl17279 997761010500 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761010501 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761010502 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761010503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010504 dimer interface [polypeptide binding]; other site 997761010505 conserved gate region; other site 997761010506 putative PBP binding loops; other site 997761010507 ABC-ATPase subunit interface; other site 997761010508 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761010509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010510 dimer interface [polypeptide binding]; other site 997761010511 conserved gate region; other site 997761010512 putative PBP binding loops; other site 997761010513 ABC-ATPase subunit interface; other site 997761010514 Response regulator receiver domain; Region: Response_reg; pfam00072 997761010515 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761010516 active site 997761010517 phosphorylation site [posttranslational modification] 997761010518 intermolecular recognition site; other site 997761010519 dimerization interface [polypeptide binding]; other site 997761010520 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761010521 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010522 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010523 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 997761010524 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 997761010525 DNA binding residues [nucleotide binding] 997761010526 putative dimer interface [polypeptide binding]; other site 997761010527 EamA-like transporter family; Region: EamA; pfam00892 997761010528 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761010529 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 997761010530 active site 997761010531 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761010532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010533 dimer interface [polypeptide binding]; other site 997761010534 conserved gate region; other site 997761010535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761010536 ABC-ATPase subunit interface; other site 997761010537 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761010538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010539 dimer interface [polypeptide binding]; other site 997761010540 conserved gate region; other site 997761010541 putative PBP binding loops; other site 997761010542 ABC-ATPase subunit interface; other site 997761010543 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761010544 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761010545 Histidine kinase; Region: His_kinase; pfam06580 997761010546 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761010547 ATP binding site [chemical binding]; other site 997761010548 Mg2+ binding site [ion binding]; other site 997761010549 G-X-G motif; other site 997761010550 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 997761010551 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 997761010552 active site 997761010553 ATP binding site [chemical binding]; other site 997761010554 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 997761010555 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761010556 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761010557 DNA binding residues [nucleotide binding] 997761010558 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 997761010559 Cytochrome P450; Region: p450; cl12078 997761010560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761010561 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 997761010562 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761010563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010564 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761010565 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010566 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 997761010567 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761010568 DNA-binding site [nucleotide binding]; DNA binding site 997761010569 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761010570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761010571 homodimer interface [polypeptide binding]; other site 997761010572 catalytic residue [active] 997761010573 glycerate kinase; Region: TIGR00045 997761010574 CAAX protease self-immunity; Region: Abi; pfam02517 997761010575 putative acetyltransferase; Provisional; Region: PRK03624 997761010576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761010577 Coenzyme A binding pocket [chemical binding]; other site 997761010578 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 997761010579 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 997761010580 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761010581 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010582 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 997761010583 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 997761010584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761010585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761010586 active site 997761010587 phosphorylation site [posttranslational modification] 997761010588 intermolecular recognition site; other site 997761010589 dimerization interface [polypeptide binding]; other site 997761010590 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761010591 non-specific DNA binding site [nucleotide binding]; other site 997761010592 salt bridge; other site 997761010593 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761010594 sequence-specific DNA binding site [nucleotide binding]; other site 997761010595 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010596 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761010597 dimerization interface [polypeptide binding]; other site 997761010598 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761010599 Histidine kinase; Region: His_kinase; pfam06580 997761010600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761010601 ATP binding site [chemical binding]; other site 997761010602 Mg2+ binding site [ion binding]; other site 997761010603 G-X-G motif; other site 997761010604 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761010605 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761010606 Response regulator receiver domain; Region: Response_reg; pfam00072 997761010607 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761010608 active site 997761010609 phosphorylation site [posttranslational modification] 997761010610 intermolecular recognition site; other site 997761010611 dimerization interface [polypeptide binding]; other site 997761010612 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761010613 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761010614 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761010615 dimerization interface [polypeptide binding]; other site 997761010616 Histidine kinase; Region: His_kinase; pfam06580 997761010617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761010618 ATP binding site [chemical binding]; other site 997761010619 Mg2+ binding site [ion binding]; other site 997761010620 G-X-G motif; other site 997761010621 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761010622 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761010623 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761010624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010625 dimer interface [polypeptide binding]; other site 997761010626 ABC-ATPase subunit interface; other site 997761010627 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761010628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010629 dimer interface [polypeptide binding]; other site 997761010630 conserved gate region; other site 997761010631 ABC-ATPase subunit interface; other site 997761010632 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 997761010633 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 997761010634 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 997761010635 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 997761010636 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761010637 Interdomain contacts; other site 997761010638 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 997761010639 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 997761010640 Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302 997761010641 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761010642 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761010643 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761010644 dimerization interface [polypeptide binding]; other site 997761010645 EamA-like transporter family; Region: EamA; pfam00892 997761010646 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 997761010647 EamA-like transporter family; Region: EamA; pfam00892 997761010648 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 997761010649 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761010650 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 997761010651 active site 997761010652 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 997761010653 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 997761010654 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 997761010655 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761010656 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761010657 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 997761010658 progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948 997761010659 NAD(P) binding site [chemical binding]; other site 997761010660 active site 997761010661 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761010662 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761010663 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 997761010664 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 997761010665 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 997761010666 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761010667 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761010668 putative substrate translocation pore; other site 997761010669 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 997761010670 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 997761010671 hypothetical protein; Provisional; Region: PRK07206 997761010672 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761010673 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 997761010674 H+ Antiporter protein; Region: 2A0121; TIGR00900 997761010675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761010676 putative substrate translocation pore; other site 997761010677 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 997761010678 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 997761010679 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 997761010680 Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144 997761010681 ATP-grasp domain; Region: ATP-grasp_4; cl17255 997761010682 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 997761010683 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 997761010684 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 997761010685 catalytic triad [active] 997761010686 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 997761010687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010688 dimer interface [polypeptide binding]; other site 997761010689 conserved gate region; other site 997761010690 putative PBP binding loops; other site 997761010691 ABC-ATPase subunit interface; other site 997761010692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 997761010693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010694 dimer interface [polypeptide binding]; other site 997761010695 conserved gate region; other site 997761010696 putative PBP binding loops; other site 997761010697 ABC-ATPase subunit interface; other site 997761010698 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 997761010699 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 997761010700 Walker A/P-loop; other site 997761010701 ATP binding site [chemical binding]; other site 997761010702 Q-loop/lid; other site 997761010703 ABC transporter signature motif; other site 997761010704 Walker B; other site 997761010705 D-loop; other site 997761010706 H-loop/switch region; other site 997761010707 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 997761010708 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 997761010709 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 997761010710 putative metal binding site [ion binding]; other site 997761010711 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 997761010712 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 997761010713 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761010714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010715 dimer interface [polypeptide binding]; other site 997761010716 conserved gate region; other site 997761010717 putative PBP binding loops; other site 997761010718 ABC-ATPase subunit interface; other site 997761010719 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761010720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761010721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010722 putative PBP binding loops; other site 997761010723 dimer interface [polypeptide binding]; other site 997761010724 ABC-ATPase subunit interface; other site 997761010725 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761010726 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761010727 argininosuccinate lyase; Provisional; Region: PRK06705 997761010728 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 997761010729 active sites [active] 997761010730 tetramer interface [polypeptide binding]; other site 997761010731 dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021 997761010732 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 997761010733 active site 997761010734 dimer interface [polypeptide binding]; other site 997761010735 non-prolyl cis peptide bond; other site 997761010736 insertion regions; other site 997761010737 Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368 997761010738 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 997761010739 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 997761010740 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761010741 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761010742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761010743 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 997761010744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010745 dimer interface [polypeptide binding]; other site 997761010746 conserved gate region; other site 997761010747 putative PBP binding loops; other site 997761010748 ABC-ATPase subunit interface; other site 997761010749 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761010750 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761010751 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761010752 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761010753 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010754 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010755 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010756 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761010757 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010758 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 997761010759 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761010760 NAD(P) binding site [chemical binding]; other site 997761010761 active site 997761010762 SnoaL-like domain; Region: SnoaL_4; pfam13577 997761010763 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 997761010764 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 997761010765 active site residue [active] 997761010766 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 997761010767 active site residue [active] 997761010768 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 997761010769 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 997761010770 active site 997761010771 non-prolyl cis peptide bond; other site 997761010772 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 997761010773 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 997761010774 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 997761010775 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761010776 Coenzyme A binding pocket [chemical binding]; other site 997761010777 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 997761010778 hydroxyglutarate oxidase; Provisional; Region: PRK11728 997761010779 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 997761010780 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 997761010781 metal binding site [ion binding]; metal-binding site 997761010782 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761010783 Coenzyme A binding pocket [chemical binding]; other site 997761010784 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 997761010785 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 997761010786 Walker A/P-loop; other site 997761010787 ATP binding site [chemical binding]; other site 997761010788 Q-loop/lid; other site 997761010789 ABC transporter signature motif; other site 997761010790 Walker B; other site 997761010791 D-loop; other site 997761010792 H-loop/switch region; other site 997761010793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010794 dimer interface [polypeptide binding]; other site 997761010795 conserved gate region; other site 997761010796 putative PBP binding loops; other site 997761010797 ABC-ATPase subunit interface; other site 997761010798 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 997761010799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010800 dimer interface [polypeptide binding]; other site 997761010801 conserved gate region; other site 997761010802 putative PBP binding loops; other site 997761010803 ABC-ATPase subunit interface; other site 997761010804 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 997761010805 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761010806 substrate binding pocket [chemical binding]; other site 997761010807 membrane-bound complex binding site; other site 997761010808 hinge residues; other site 997761010809 DinB superfamily; Region: DinB_2; pfam12867 997761010810 metal-dependent hydrolase; Provisional; Region: PRK13291 997761010811 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 997761010812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010813 dimer interface [polypeptide binding]; other site 997761010814 conserved gate region; other site 997761010815 putative PBP binding loops; other site 997761010816 ABC-ATPase subunit interface; other site 997761010817 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 997761010818 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 997761010819 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 997761010820 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 997761010821 active site 997761010822 non-prolyl cis peptide bond; other site 997761010823 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 997761010824 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 997761010825 cell density-dependent motility repressor; Provisional; Region: PRK10082 997761010826 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761010827 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761010828 dimerization interface [polypeptide binding]; other site 997761010829 DoxX-like family; Region: DoxX_2; pfam13564 997761010830 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 997761010831 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 997761010832 Sulfatase; Region: Sulfatase; pfam00884 997761010833 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 997761010834 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 997761010835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010836 dimer interface [polypeptide binding]; other site 997761010837 conserved gate region; other site 997761010838 putative PBP binding loops; other site 997761010839 ABC-ATPase subunit interface; other site 997761010840 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 997761010841 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 997761010842 Walker A/P-loop; other site 997761010843 ATP binding site [chemical binding]; other site 997761010844 Q-loop/lid; other site 997761010845 ABC transporter signature motif; other site 997761010846 Walker B; other site 997761010847 D-loop; other site 997761010848 H-loop/switch region; other site 997761010849 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 997761010850 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761010851 substrate binding pocket [chemical binding]; other site 997761010852 membrane-bound complex binding site; other site 997761010853 hinge residues; other site 997761010854 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761010855 MarR family; Region: MarR; pfam01047 997761010856 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761010857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761010858 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761010859 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010860 dimer interface [polypeptide binding]; other site 997761010861 conserved gate region; other site 997761010862 ABC-ATPase subunit interface; other site 997761010863 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761010864 N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320 997761010865 active site 997761010866 catalytic site [active] 997761010867 Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316 997761010868 C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317 997761010869 Ca binding site [ion binding]; other site 997761010870 substrate binding site [chemical binding]; other site 997761010871 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761010872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010873 Helix-turn-helix domain; Region: HTH_18; pfam12833 997761010874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010875 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 997761010876 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 997761010877 active site 997761010878 non-prolyl cis peptide bond; other site 997761010879 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 997761010880 active site 997761010881 metal binding site [ion binding]; metal-binding site 997761010882 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761010883 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 997761010884 nudix motif; other site 997761010885 C factor cell-cell signaling protein; Provisional; Region: PRK09009 997761010886 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 997761010887 NADP binding site [chemical binding]; other site 997761010888 homodimer interface [polypeptide binding]; other site 997761010889 active site 997761010890 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 997761010891 dimer interface [polypeptide binding]; other site 997761010892 substrate binding site [chemical binding]; other site 997761010893 metal binding site [ion binding]; metal-binding site 997761010894 Protein of unknown function (DUF817); Region: DUF817; pfam05675 997761010895 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 997761010896 metal-binding site [ion binding] 997761010897 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 997761010898 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 997761010899 active site 997761010900 catalytic residues [active] 997761010901 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 997761010902 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 997761010903 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 997761010904 Protein of unknown function (DUF1533); Region: DUF1533; pfam07550 997761010905 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 997761010906 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761010907 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761010908 DNA binding site [nucleotide binding] 997761010909 domain linker motif; other site 997761010910 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 997761010911 dimerization interface [polypeptide binding]; other site 997761010912 ligand binding site [chemical binding]; other site 997761010913 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761010914 dimerization interface [polypeptide binding]; other site 997761010915 putative DNA binding site [nucleotide binding]; other site 997761010916 putative Zn2+ binding site [ion binding]; other site 997761010917 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761010918 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761010919 dimer interface [polypeptide binding]; other site 997761010920 phosphorylation site [posttranslational modification] 997761010921 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761010922 ATP binding site [chemical binding]; other site 997761010923 Mg2+ binding site [ion binding]; other site 997761010924 G-X-G motif; other site 997761010925 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761010926 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761010927 active site 997761010928 phosphorylation site [posttranslational modification] 997761010929 intermolecular recognition site; other site 997761010930 dimerization interface [polypeptide binding]; other site 997761010931 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761010932 DNA binding site [nucleotide binding] 997761010933 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 997761010934 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 997761010935 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 997761010936 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761010937 Walker A/P-loop; other site 997761010938 ATP binding site [chemical binding]; other site 997761010939 Q-loop/lid; other site 997761010940 ABC transporter signature motif; other site 997761010941 Walker B; other site 997761010942 D-loop; other site 997761010943 H-loop/switch region; other site 997761010944 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761010945 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761010946 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 997761010947 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 997761010948 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761010949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010950 dimer interface [polypeptide binding]; other site 997761010951 conserved gate region; other site 997761010952 putative PBP binding loops; other site 997761010953 ABC-ATPase subunit interface; other site 997761010954 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 997761010955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761010956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761010957 putative PBP binding loops; other site 997761010958 dimer interface [polypeptide binding]; other site 997761010959 ABC-ATPase subunit interface; other site 997761010960 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761010961 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761010962 Response regulator receiver domain; Region: Response_reg; pfam00072 997761010963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761010964 active site 997761010965 phosphorylation site [posttranslational modification] 997761010966 intermolecular recognition site; other site 997761010967 dimerization interface [polypeptide binding]; other site 997761010968 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010969 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761010970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010971 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761010972 HAMP domain; Region: HAMP; pfam00672 997761010973 Histidine kinase; Region: His_kinase; pfam06580 997761010974 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761010975 ATP binding site [chemical binding]; other site 997761010976 Mg2+ binding site [ion binding]; other site 997761010977 G-X-G motif; other site 997761010978 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 997761010979 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 997761010980 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 997761010981 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 997761010982 active site 997761010983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 997761010984 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 997761010985 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761010986 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761010987 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 997761010988 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761010989 DNA-binding site [nucleotide binding]; DNA binding site 997761010990 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761010991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761010992 homodimer interface [polypeptide binding]; other site 997761010993 catalytic residue [active] 997761010994 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 997761010995 EamA-like transporter family; Region: EamA; pfam00892 997761010996 EamA-like transporter family; Region: EamA; pfam00892 997761010997 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 997761010998 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 997761010999 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 997761011000 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 997761011001 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 997761011002 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761011003 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761011004 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761011005 active site 997761011006 catalytic tetrad [active] 997761011007 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761011008 Spore germination protein; Region: Spore_permease; cl17796 997761011009 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761011010 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761011011 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 997761011012 putative trimer interface [polypeptide binding]; other site 997761011013 putative CoA binding site [chemical binding]; other site 997761011014 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 997761011015 putative trimer interface [polypeptide binding]; other site 997761011016 putative CoA binding site [chemical binding]; other site 997761011017 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 997761011018 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 997761011019 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 997761011020 Walker A/P-loop; other site 997761011021 ATP binding site [chemical binding]; other site 997761011022 Q-loop/lid; other site 997761011023 ABC transporter signature motif; other site 997761011024 Walker B; other site 997761011025 D-loop; other site 997761011026 H-loop/switch region; other site 997761011027 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 997761011028 H+ Antiporter protein; Region: 2A0121; TIGR00900 997761011029 2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944 997761011030 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 997761011031 2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945 997761011032 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 997761011033 dimer interface [polypeptide binding]; other site 997761011034 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761011035 catalytic residue [active] 997761011036 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761011037 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761011038 active site 997761011039 phosphorylation site [posttranslational modification] 997761011040 dimerization interface [polypeptide binding]; other site 997761011041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761011042 DNA binding site [nucleotide binding] 997761011043 ATP-grasp domain; Region: ATP-grasp_4; cl17255 997761011044 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 997761011045 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 997761011046 dimer interface [polypeptide binding]; other site 997761011047 active site 997761011048 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 997761011049 catalytic residues [active] 997761011050 substrate binding site [chemical binding]; other site 997761011051 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 997761011052 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 997761011053 active site 997761011054 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 997761011055 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 997761011056 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 997761011057 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 997761011058 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761011059 Walker A/P-loop; other site 997761011060 ATP binding site [chemical binding]; other site 997761011061 Q-loop/lid; other site 997761011062 ABC transporter signature motif; other site 997761011063 Walker B; other site 997761011064 D-loop; other site 997761011065 H-loop/switch region; other site 997761011066 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761011067 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761011068 tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317 997761011069 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761011070 FeS/SAM binding site; other site 997761011071 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 997761011072 Phosphopantetheine attachment site; Region: PP-binding; cl09936 997761011073 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 997761011074 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 997761011075 substrate binding site [chemical binding]; other site 997761011076 active site 997761011077 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 997761011078 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761011079 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761011080 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 997761011081 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043 997761011082 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 997761011083 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 997761011084 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 997761011085 sulfite reductase subunit beta; Provisional; Region: PRK13504 997761011086 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 997761011087 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 997761011088 Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237 997761011089 Calx-beta domain; Region: Calx-beta; pfam03160 997761011090 Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237 997761011091 Calx-beta domain; Region: Calx-beta; cl02522 997761011092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761011093 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 997761011094 Walker A motif; other site 997761011095 ATP binding site [chemical binding]; other site 997761011096 Walker B motif; other site 997761011097 arginine finger; other site 997761011098 UvrB/uvrC motif; Region: UVR; pfam02151 997761011099 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761011100 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 997761011101 Walker A motif; other site 997761011102 ATP binding site [chemical binding]; other site 997761011103 Walker B motif; other site 997761011104 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 997761011105 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761011106 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761011107 CHASE3 domain; Region: CHASE3; cl05000 997761011108 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761011109 dimerization interface [polypeptide binding]; other site 997761011110 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761011111 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761011112 dimer interface [polypeptide binding]; other site 997761011113 putative CheW interface [polypeptide binding]; other site 997761011114 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761011115 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 997761011116 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 997761011117 Predicted transcriptional regulator [Transcription]; Region: COG2378 997761011118 HTH domain; Region: HTH_11; pfam08279 997761011119 WYL domain; Region: WYL; pfam13280 997761011120 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761011121 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761011122 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761011123 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 997761011124 chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937 997761011125 Chromate transporter; Region: Chromate_transp; pfam02417 997761011126 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 997761011127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761011128 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761011129 dimer interface [polypeptide binding]; other site 997761011130 phosphorylation site [posttranslational modification] 997761011131 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761011132 ATP binding site [chemical binding]; other site 997761011133 Mg2+ binding site [ion binding]; other site 997761011134 G-X-G motif; other site 997761011135 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 997761011136 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 997761011137 acyl-activating enzyme (AAE) consensus motif; other site 997761011138 AMP binding site [chemical binding]; other site 997761011139 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761011140 Condensation domain; Region: Condensation; pfam00668 997761011141 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 997761011142 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 997761011143 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 997761011144 acyl-activating enzyme (AAE) consensus motif; other site 997761011145 AMP binding site [chemical binding]; other site 997761011146 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761011147 Condensation domain; Region: Condensation; pfam00668 997761011148 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 997761011149 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 997761011150 Condensation domain; Region: Condensation; pfam00668 997761011151 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 997761011152 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 997761011153 acyl-activating enzyme (AAE) consensus motif; other site 997761011154 AMP binding site [chemical binding]; other site 997761011155 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761011156 Thioesterase domain; Region: Thioesterase; pfam00975 997761011157 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 997761011158 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761011159 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761011160 Walker A/P-loop; other site 997761011161 ATP binding site [chemical binding]; other site 997761011162 Q-loop/lid; other site 997761011163 ABC transporter signature motif; other site 997761011164 Walker B; other site 997761011165 D-loop; other site 997761011166 H-loop/switch region; other site 997761011167 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 997761011168 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 997761011169 inhibitor-cofactor binding pocket; inhibition site 997761011170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761011171 catalytic residue [active] 997761011172 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 997761011173 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 997761011174 metal ion-dependent adhesion site (MIDAS); other site 997761011175 TraB family; Region: TraB; cl12050 997761011176 MoxR-like ATPases [General function prediction only]; Region: COG0714 997761011177 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 997761011178 Walker A motif; other site 997761011179 ATP binding site [chemical binding]; other site 997761011180 Walker B motif; other site 997761011181 arginine finger; other site 997761011182 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 997761011183 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 997761011184 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 997761011185 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 997761011186 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 997761011187 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 997761011188 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761011189 FeS/SAM binding site; other site 997761011190 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 997761011191 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 997761011192 Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006 997761011193 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 997761011194 CPxP motif; other site 997761011195 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 997761011196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 997761011197 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 997761011198 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 997761011199 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 997761011200 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761011201 putative substrate translocation pore; other site 997761011202 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 997761011203 Phosphotransferase enzyme family; Region: APH; pfam01636 997761011204 putative active site [active] 997761011205 putative substrate binding site [chemical binding]; other site 997761011206 ATP binding site [chemical binding]; other site 997761011207 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 997761011208 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 997761011209 dimer interface [polypeptide binding]; other site 997761011210 active site 997761011211 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761011212 salt bridge; other site 997761011213 non-specific DNA binding site [nucleotide binding]; other site 997761011214 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 997761011215 sequence-specific DNA binding site [nucleotide binding]; other site 997761011216 aminoglycoside resistance protein; Provisional; Region: PRK13746 997761011217 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 997761011218 active site 997761011219 NTP binding site [chemical binding]; other site 997761011220 metal binding triad [ion binding]; metal-binding site 997761011221 antibiotic binding site [chemical binding]; other site 997761011222 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 997761011223 Methyltransferase domain; Region: Methyltransf_23; pfam13489 997761011224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761011225 S-adenosylmethionine binding site [chemical binding]; other site 997761011226 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 997761011227 NmrA-like family; Region: NmrA; pfam05368 997761011228 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761011229 NAD(P) binding site [chemical binding]; other site 997761011230 active site 997761011231 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 997761011232 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761011233 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761011234 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 997761011235 putative dimerization interface [polypeptide binding]; other site 997761011236 Predicted metalloprotease [General function prediction only]; Region: COG2321 997761011237 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 997761011238 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 997761011239 H+ Antiporter protein; Region: 2A0121; TIGR00900 997761011240 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761011241 putative substrate translocation pore; other site 997761011242 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 997761011243 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 997761011244 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132 997761011245 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 997761011246 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 997761011247 active site 997761011248 acyl-CoA synthetase; Validated; Region: PRK05850 997761011249 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 997761011250 acyl-activating enzyme (AAE) consensus motif; other site 997761011251 active site 997761011252 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 997761011253 Condensation domain; Region: Condensation; pfam00668 997761011254 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 997761011255 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 997761011256 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 997761011257 acyl-activating enzyme (AAE) consensus motif; other site 997761011258 AMP binding site [chemical binding]; other site 997761011259 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 997761011260 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761011261 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761011262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761011263 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 997761011264 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 997761011265 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 997761011266 active site 997761011267 Zn binding site [ion binding]; other site 997761011268 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 997761011269 dimer interface [polypeptide binding]; other site 997761011270 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761011271 Class I aldolases; Region: Aldolase_Class_I; cl17187 997761011272 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 997761011273 Uncharacterized conserved protein [Function unknown]; Region: COG2135 997761011274 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 997761011275 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 997761011276 Part of AAA domain; Region: AAA_19; pfam13245 997761011277 Family description; Region: UvrD_C_2; pfam13538 997761011278 putative transporter; Provisional; Region: PRK11021 997761011279 Spore germination protein; Region: Spore_permease; cl17796 997761011280 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 997761011281 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761011282 DNA-binding site [nucleotide binding]; DNA binding site 997761011283 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761011284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761011285 homodimer interface [polypeptide binding]; other site 997761011286 catalytic residue [active] 997761011287 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761011288 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 997761011289 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 997761011290 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761011291 Domain of unknown function (DUF4362); Region: DUF4362; pfam14275 997761011292 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 997761011293 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 997761011294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 997761011295 2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274 997761011296 Chitin binding domain; Region: Chitin_bind_3; pfam03067 997761011297 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 997761011298 aromatic chitin/cellulose binding site residues [chemical binding]; other site 997761011299 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 997761011300 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761011301 Interdomain contacts; other site 997761011302 Cytokine receptor motif; other site 997761011303 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 997761011304 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 997761011305 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761011306 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761011307 DNA binding site [nucleotide binding] 997761011308 domain linker motif; other site 997761011309 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 997761011310 dimerization interface [polypeptide binding]; other site 997761011311 ligand binding site [chemical binding]; other site 997761011312 tellurium resistance terB-like protein; Region: terB_like; cd07177 997761011313 metal binding site [ion binding]; metal-binding site 997761011314 Cytochrome P450; Region: p450; pfam00067 997761011315 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 997761011316 DinB superfamily; Region: DinB_2; pfam12867 997761011317 protoporphyrinogen oxidase; Provisional; Region: PRK12416 997761011318 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 997761011319 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 997761011320 Response regulator receiver domain; Region: Response_reg; pfam00072 997761011321 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761011322 active site 997761011323 phosphorylation site [posttranslational modification] 997761011324 intermolecular recognition site; other site 997761011325 dimerization interface [polypeptide binding]; other site 997761011326 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761011327 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761011328 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761011329 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761011330 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761011331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761011332 dimer interface [polypeptide binding]; other site 997761011333 conserved gate region; other site 997761011334 putative PBP binding loops; other site 997761011335 ABC-ATPase subunit interface; other site 997761011336 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 997761011337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761011338 dimer interface [polypeptide binding]; other site 997761011339 conserved gate region; other site 997761011340 putative PBP binding loops; other site 997761011341 ABC-ATPase subunit interface; other site 997761011342 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761011343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761011344 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 997761011345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761011346 putative substrate translocation pore; other site 997761011347 Spore germination protein; Region: Spore_permease; cl17796 997761011348 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761011349 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 997761011350 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 997761011351 NAD binding site [chemical binding]; other site 997761011352 dimer interface [polypeptide binding]; other site 997761011353 substrate binding site [chemical binding]; other site 997761011354 tetramer (dimer of dimers) interface [polypeptide binding]; other site 997761011355 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 997761011356 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 997761011357 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 997761011358 Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831 997761011359 malonyl-CoA binding site [chemical binding]; other site 997761011360 dimer interface [polypeptide binding]; other site 997761011361 active site 997761011362 product binding site; other site 997761011363 Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859 997761011364 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 997761011365 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 997761011366 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 997761011367 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 997761011368 [2Fe-2S] cluster binding site [ion binding]; other site 997761011369 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 997761011370 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761011371 NAD(P) binding site [chemical binding]; other site 997761011372 active site 997761011373 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 997761011374 FlgD Ig-like domain; Region: FlgD_ig; pfam13860 997761011375 Protein of unknown function (DUF975); Region: DUF975; cl10504 997761011376 S-layer homology domain; Region: SLH; pfam00395 997761011377 S-layer homology domain; Region: SLH; pfam00395 997761011378 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 997761011379 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 997761011380 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 997761011381 active site 997761011382 metal binding site [ion binding]; metal-binding site 997761011383 Spore germination protein; Region: Spore_permease; cl17796 997761011384 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761011385 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761011386 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761011387 Predicted amidohydrolase [General function prediction only]; Region: COG0388 997761011388 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 997761011389 active site 997761011390 catalytic triad [active] 997761011391 dimer interface [polypeptide binding]; other site 997761011392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 997761011393 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 997761011394 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761011395 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761011396 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 997761011397 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 997761011398 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 997761011399 minor groove reading motif; other site 997761011400 helix-hairpin-helix signature motif; other site 997761011401 substrate binding pocket [chemical binding]; other site 997761011402 active site 997761011403 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 997761011404 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 997761011405 DNA binding site [nucleotide binding] 997761011406 active site 997761011407 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 997761011408 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 997761011409 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761011410 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 997761011411 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 997761011412 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 997761011413 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761011414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761011415 putative substrate translocation pore; other site 997761011416 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 997761011417 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761011418 heat shock protein 90; Provisional; Region: PRK05218 997761011419 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761011420 ATP binding site [chemical binding]; other site 997761011421 Mg2+ binding site [ion binding]; other site 997761011422 G-X-G motif; other site 997761011423 Squalene/phytoene synthase; Region: SQS_PSY; pfam00494 997761011424 substrate binding pocket [chemical binding]; other site 997761011425 substrate-Mg2+ binding site; other site 997761011426 aspartate-rich region 1; other site 997761011427 aspartate-rich region 2; other site 997761011428 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 997761011429 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 997761011430 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 997761011431 short chain dehydrogenase; Provisional; Region: PRK07062 997761011432 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761011433 NAD(P) binding site [chemical binding]; other site 997761011434 active site 997761011435 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 997761011436 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 997761011437 phosphopentomutase; Provisional; Region: PRK05362 997761011438 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 997761011439 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 997761011440 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 997761011441 Nucleoside recognition; Region: Gate; pfam07670 997761011442 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 997761011443 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 997761011444 active site 997761011445 catalytic motif [active] 997761011446 Zn binding site [ion binding]; other site 997761011447 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 997761011448 intersubunit interface [polypeptide binding]; other site 997761011449 active site 997761011450 catalytic residue [active] 997761011451 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 997761011452 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 997761011453 non-specific DNA interactions [nucleotide binding]; other site 997761011454 DNA binding site [nucleotide binding] 997761011455 sequence specific DNA binding site [nucleotide binding]; other site 997761011456 putative cAMP binding site [chemical binding]; other site 997761011457 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 997761011458 DNA polymerase III subunit beta; Validated; Region: PRK05643 997761011459 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 997761011460 putative DNA binding surface [nucleotide binding]; other site 997761011461 dimer interface [polypeptide binding]; other site 997761011462 beta-clamp/clamp loader binding surface; other site 997761011463 beta-clamp/translesion DNA polymerase binding surface; other site 997761011464 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 997761011465 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 997761011466 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 997761011467 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 997761011468 dimer interface [polypeptide binding]; other site 997761011469 FMN binding site [chemical binding]; other site 997761011470 Rrf2 family protein; Region: rrf2_super; TIGR00738 997761011471 Transcriptional regulator; Region: Rrf2; pfam02082 997761011472 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 997761011473 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 997761011474 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 997761011475 substrate binding site [chemical binding]; other site 997761011476 active site 997761011477 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 997761011478 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 997761011479 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761011480 Phytochelatin synthase; Region: Phytochelatin; pfam05023 997761011481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761011482 dimer interface [polypeptide binding]; other site 997761011483 conserved gate region; other site 997761011484 putative PBP binding loops; other site 997761011485 ABC-ATPase subunit interface; other site 997761011486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761011487 dimer interface [polypeptide binding]; other site 997761011488 conserved gate region; other site 997761011489 putative PBP binding loops; other site 997761011490 ABC-ATPase subunit interface; other site 997761011491 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761011492 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761011493 Predicted transcriptional regulator [Transcription]; Region: COG4189 997761011494 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761011495 dimerization interface [polypeptide binding]; other site 997761011496 putative DNA binding site [nucleotide binding]; other site 997761011497 putative Zn2+ binding site [ion binding]; other site 997761011498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761011499 PAS domain; Region: PAS_9; pfam13426 997761011500 putative active site [active] 997761011501 heme pocket [chemical binding]; other site 997761011502 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 997761011503 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 997761011504 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761011505 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761011506 Interdomain contacts; other site 997761011507 Cytokine receptor motif; other site 997761011508 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 997761011509 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 997761011510 Moco binding site; other site 997761011511 metal coordination site [ion binding]; other site 997761011512 YolD-like protein; Region: YolD; pfam08863 997761011513 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 997761011514 dimer interface [polypeptide binding]; other site 997761011515 [2Fe-2S] cluster binding site [ion binding]; other site 997761011516 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 997761011517 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 997761011518 ligand binding site [chemical binding]; other site 997761011519 flexible hinge region; other site 997761011520 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 997761011521 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 997761011522 DoxX-like family; Region: DoxX_3; pfam13781 997761011523 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 997761011524 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 997761011525 DNA binding residues [nucleotide binding] 997761011526 putative dimer interface [polypeptide binding]; other site 997761011527 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 997761011528 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 997761011529 catalytic residues [active] 997761011530 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 997761011531 Domain of unknown function DUF21; Region: DUF21; pfam01595 997761011532 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 997761011533 Transporter associated domain; Region: CorC_HlyC; smart01091 997761011534 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 997761011535 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761011536 DTW domain; Region: DTW; cl01221 997761011537 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 997761011538 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761011539 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 997761011540 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 997761011541 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 997761011542 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761011543 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 997761011544 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 997761011545 protein binding site [polypeptide binding]; other site 997761011546 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761011547 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761011548 NAD(P) binding site [chemical binding]; other site 997761011549 active site 997761011550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761011551 S-adenosylmethionine binding site [chemical binding]; other site 997761011552 putative phosphoesterase; Region: acc_ester; TIGR03729 997761011553 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 997761011554 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950 997761011555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761011556 Coenzyme A binding pocket [chemical binding]; other site 997761011557 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761011558 HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7 997761011559 S-layer homology domain; Region: SLH; pfam00395 997761011560 S-layer homology domain; Region: SLH; pfam00395 997761011561 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 997761011562 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 997761011563 protein binding site [polypeptide binding]; other site 997761011564 C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567 997761011565 Active site serine [active] 997761011566 Bacterial Ig-like domain; Region: Big_5; pfam13205 997761011567 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 997761011568 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 997761011569 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 997761011570 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 997761011571 Zn2+ binding site [ion binding]; other site 997761011572 Mg2+ binding site [ion binding]; other site 997761011573 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 997761011574 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 997761011575 ATP binding site [chemical binding]; other site 997761011576 Mg2+ binding site [ion binding]; other site 997761011577 G-X-G motif; other site 997761011578 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 997761011579 anti sigma factor interaction site; other site 997761011580 regulatory phosphorylation site [posttranslational modification]; other site 997761011581 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 997761011582 FAD dependent oxidoreductase; Region: DAO; pfam01266 997761011583 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 997761011584 DNA-binding site [nucleotide binding]; DNA binding site 997761011585 RNA-binding motif; other site 997761011586 Rhomboid family; Region: Rhomboid; pfam01694 997761011587 Coat F domain; Region: Coat_F; pfam07875 997761011588 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761011589 active site 997761011590 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761011591 catalytic tetrad [active] 997761011592 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 997761011593 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761011594 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761011595 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 997761011596 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 997761011597 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 997761011598 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 997761011599 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 997761011600 Walker A/P-loop; other site 997761011601 ATP binding site [chemical binding]; other site 997761011602 Q-loop/lid; other site 997761011603 ABC transporter signature motif; other site 997761011604 Walker B; other site 997761011605 D-loop; other site 997761011606 H-loop/switch region; other site 997761011607 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 997761011608 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 997761011609 Walker A/P-loop; other site 997761011610 ATP binding site [chemical binding]; other site 997761011611 Q-loop/lid; other site 997761011612 ABC transporter signature motif; other site 997761011613 Walker B; other site 997761011614 D-loop; other site 997761011615 H-loop/switch region; other site 997761011616 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 997761011617 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 997761011618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761011619 dimer interface [polypeptide binding]; other site 997761011620 conserved gate region; other site 997761011621 putative PBP binding loops; other site 997761011622 ABC-ATPase subunit interface; other site 997761011623 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 997761011624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761011625 dimer interface [polypeptide binding]; other site 997761011626 conserved gate region; other site 997761011627 putative PBP binding loops; other site 997761011628 ABC-ATPase subunit interface; other site 997761011629 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 997761011630 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 997761011631 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 997761011632 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 997761011633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761011634 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 997761011635 Coenzyme A binding pocket [chemical binding]; other site 997761011636 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 997761011637 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 997761011638 NAD binding site [chemical binding]; other site 997761011639 catalytic Zn binding site [ion binding]; other site 997761011640 structural Zn binding site [ion binding]; other site 997761011641 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 997761011642 active site 997761011643 catalytic residues [active] 997761011644 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 997761011645 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 997761011646 putative sugar binding sites [chemical binding]; other site 997761011647 Q-X-W motif; other site 997761011648 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 997761011649 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 997761011650 substrate binding site [chemical binding]; other site 997761011651 multimerization interface [polypeptide binding]; other site 997761011652 ATP binding site [chemical binding]; other site 997761011653 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 997761011654 Cytochrome P450; Region: p450; cl12078 997761011655 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761011656 MarR family; Region: MarR; pfam01047 997761011657 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761011658 Coenzyme A binding pocket [chemical binding]; other site 997761011659 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 997761011660 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 997761011661 SpoVR like protein; Region: SpoVR; pfam04293 997761011662 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 997761011663 metal ion-dependent adhesion site (MIDAS); other site 997761011664 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 997761011665 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 997761011666 Domain of unknown function (DUF4281); Region: DUF4281; pfam14108 997761011667 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761011668 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761011669 PAS domain S-box; Region: sensory_box; TIGR00229 997761011670 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761011671 putative active site [active] 997761011672 heme pocket [chemical binding]; other site 997761011673 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 997761011674 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761011675 putative active site [active] 997761011676 heme pocket [chemical binding]; other site 997761011677 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761011678 dimer interface [polypeptide binding]; other site 997761011679 phosphorylation site [posttranslational modification] 997761011680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761011681 ATP binding site [chemical binding]; other site 997761011682 Mg2+ binding site [ion binding]; other site 997761011683 G-X-G motif; other site 997761011684 Response regulator receiver domain; Region: Response_reg; pfam00072 997761011685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761011686 active site 997761011687 phosphorylation site [posttranslational modification] 997761011688 intermolecular recognition site; other site 997761011689 dimerization interface [polypeptide binding]; other site 997761011690 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 997761011691 nudix motif; other site 997761011692 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 997761011693 putative dimer interface [polypeptide binding]; other site 997761011694 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761011695 ligand binding site [chemical binding]; other site 997761011696 Zn binding site [ion binding]; other site 997761011697 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 997761011698 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 997761011699 metal ion-dependent adhesion site (MIDAS); other site 997761011700 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 997761011701 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 997761011702 homodimer interface [polypeptide binding]; other site 997761011703 substrate-cofactor binding pocket; other site 997761011704 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761011705 catalytic residue [active] 997761011706 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 997761011707 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 997761011708 Substrate-binding site [chemical binding]; other site 997761011709 Substrate specificity [chemical binding]; other site 997761011710 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 997761011711 catalytic triad [active] 997761011712 conserved cis-peptide bond; other site 997761011713 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 997761011714 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 997761011715 peptide binding site [polypeptide binding]; other site 997761011716 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 997761011717 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 997761011718 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 997761011719 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 997761011720 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 997761011721 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 997761011722 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 997761011723 Protein of unknown function (DUF3967); Region: DUF3967; pfam13152 997761011724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761011725 Coenzyme A binding pocket [chemical binding]; other site 997761011726 Protein of unknown function (DUF2905); Region: DUF2905; pfam11146 997761011727 Cytochrome P450; Region: p450; cl12078 997761011728 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 997761011729 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 997761011730 putative transporter; Provisional; Region: PRK11660 997761011731 Sulfate transporter family; Region: Sulfate_transp; pfam00916 997761011732 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 997761011733 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 997761011734 active site clefts [active] 997761011735 zinc binding site [ion binding]; other site 997761011736 dimer interface [polypeptide binding]; other site 997761011737 Isochorismatase family; Region: Isochorismatase; pfam00857 997761011738 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 997761011739 catalytic triad [active] 997761011740 conserved cis-peptide bond; other site 997761011741 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 997761011742 GIY-YIG motif/motif A; other site 997761011743 Pectic acid lyase; Region: Pec_lyase; pfam09492 997761011744 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 997761011745 hypothetical protein; Provisional; Region: PRK13660 997761011746 Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594 997761011747 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 997761011748 Biofilm formation and stress response factor; Region: BsmA; pfam10014 997761011749 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 997761011750 Ligand Binding Site [chemical binding]; other site 997761011751 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761011752 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761011753 DNA binding residues [nucleotide binding] 997761011754 dimerization interface [polypeptide binding]; other site 997761011755 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 997761011756 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 997761011757 G1 box; other site 997761011758 putative GEF interaction site [polypeptide binding]; other site 997761011759 GTP/Mg2+ binding site [chemical binding]; other site 997761011760 Switch I region; other site 997761011761 G2 box; other site 997761011762 G3 box; other site 997761011763 Switch II region; other site 997761011764 G4 box; other site 997761011765 G5 box; other site 997761011766 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 997761011767 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 997761011768 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 997761011769 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 997761011770 Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967 997761011771 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 997761011772 putative active site [active] 997761011773 putative metal binding site [ion binding]; other site 997761011774 multidrug efflux protein; Reviewed; Region: PRK01766 997761011775 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 997761011776 cation binding site [ion binding]; other site 997761011777 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 997761011778 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 997761011779 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761011780 non-specific DNA binding site [nucleotide binding]; other site 997761011781 salt bridge; other site 997761011782 sequence-specific DNA binding site [nucleotide binding]; other site 997761011783 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 997761011784 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 997761011785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761011786 dimer interface [polypeptide binding]; other site 997761011787 conserved gate region; other site 997761011788 putative PBP binding loops; other site 997761011789 ABC-ATPase subunit interface; other site 997761011790 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 997761011791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761011792 dimer interface [polypeptide binding]; other site 997761011793 conserved gate region; other site 997761011794 putative PBP binding loops; other site 997761011795 ABC-ATPase subunit interface; other site 997761011796 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 997761011797 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 997761011798 peptide binding site [polypeptide binding]; other site 997761011799 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 997761011800 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 997761011801 Walker A/P-loop; other site 997761011802 ATP binding site [chemical binding]; other site 997761011803 Q-loop/lid; other site 997761011804 ABC transporter signature motif; other site 997761011805 Walker B; other site 997761011806 D-loop; other site 997761011807 H-loop/switch region; other site 997761011808 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 997761011809 Phytase; Region: Phytase; cl17685 997761011810 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 997761011811 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 997761011812 NodB motif; other site 997761011813 active site 997761011814 catalytic site [active] 997761011815 Cd binding site [ion binding]; other site 997761011816 Predicted ATPase [General function prediction only]; Region: COG3910 997761011817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761011818 Walker A/P-loop; other site 997761011819 ATP binding site [chemical binding]; other site 997761011820 Q-loop/lid; other site 997761011821 ABC transporter signature motif; other site 997761011822 Walker B; other site 997761011823 D-loop; other site 997761011824 H-loop/switch region; other site 997761011825 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 997761011826 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 997761011827 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 997761011828 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761011829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761011830 dimer interface [polypeptide binding]; other site 997761011831 phosphorylation site [posttranslational modification] 997761011832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761011833 ATP binding site [chemical binding]; other site 997761011834 Mg2+ binding site [ion binding]; other site 997761011835 G-X-G motif; other site 997761011836 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 997761011837 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 997761011838 Walker A/P-loop; other site 997761011839 ATP binding site [chemical binding]; other site 997761011840 Q-loop/lid; other site 997761011841 ABC transporter signature motif; other site 997761011842 Walker B; other site 997761011843 D-loop; other site 997761011844 H-loop/switch region; other site 997761011845 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 997761011846 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 997761011847 metal-dependent hydrolase; Provisional; Region: PRK13291 997761011848 DinB superfamily; Region: DinB_2; pfam12867 997761011849 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 997761011850 hydrophobic ligand binding site; other site 997761011851 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761011852 dimerization interface [polypeptide binding]; other site 997761011853 putative DNA binding site [nucleotide binding]; other site 997761011854 putative Zn2+ binding site [ion binding]; other site 997761011855 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761011856 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 997761011857 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 997761011858 putative FMN binding site [chemical binding]; other site 997761011859 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 997761011860 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 997761011861 metal binding site [ion binding]; metal-binding site 997761011862 Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_7; cd06244 997761011863 putative active site [active] 997761011864 Zn binding site [ion binding]; other site 997761011865 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 997761011866 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 997761011867 DNA binding residues [nucleotide binding] 997761011868 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 997761011869 TAP-like protein; Region: Abhydrolase_4; pfam08386 997761011870 Protein of unknown function (DUF2807); Region: DUF2807; pfam10988 997761011871 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 997761011872 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 997761011873 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761011874 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761011875 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 997761011876 Transcriptional regulator PadR-like family; Region: PadR; cl17335 997761011877 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 997761011878 Uncharacterized conserved protein [Function unknown]; Region: COG1683 997761011879 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761011880 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 997761011881 ABC transporter; Region: ABC_tran_2; pfam12848 997761011882 ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133 997761011883 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 997761011884 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 997761011885 CoenzymeA binding site [chemical binding]; other site 997761011886 subunit interaction site [polypeptide binding]; other site 997761011887 PHB binding site; other site 997761011888 Predicted transcriptional regulator [Transcription]; Region: COG1959 997761011889 Transcriptional regulator; Region: Rrf2; pfam02082 997761011890 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 997761011891 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761011892 Interdomain contacts; other site 997761011893 Cytokine receptor motif; other site 997761011894 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 997761011895 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761011896 TATA Binding Protein (TBP) Associated Factor 9 (TAF9) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; Region: TAF9; cl17378 997761011897 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761011898 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761011899 dimer interface [polypeptide binding]; other site 997761011900 conserved gate region; other site 997761011901 putative PBP binding loops; other site 997761011902 ABC-ATPase subunit interface; other site 997761011903 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761011904 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761011905 dimer interface [polypeptide binding]; other site 997761011906 conserved gate region; other site 997761011907 putative PBP binding loops; other site 997761011908 ABC-ATPase subunit interface; other site 997761011909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761011910 active site 997761011911 phosphorylation site [posttranslational modification] 997761011912 intermolecular recognition site; other site 997761011913 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761011914 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761011915 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761011916 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 997761011917 Histidine kinase; Region: His_kinase; pfam06580 997761011918 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 997761011919 ATP binding site [chemical binding]; other site 997761011920 Mg2+ binding site [ion binding]; other site 997761011921 G-X-G motif; other site 997761011922 CAAX protease self-immunity; Region: Abi; pfam02517 997761011923 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 997761011924 pentamer interface [polypeptide binding]; other site 997761011925 dodecaamer interface [polypeptide binding]; other site 997761011926 YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724 997761011927 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 997761011928 substrate binding site [chemical binding]; other site 997761011929 catalytic residues [active] 997761011930 S-layer homology domain; Region: SLH; pfam00395 997761011931 S-layer homology domain; Region: SLH; pfam00395 997761011932 S-layer homology domain; Region: SLH; pfam00395 997761011933 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 997761011934 Cytochrome P450; Region: p450; cl12078 997761011935 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 997761011936 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 997761011937 DNA interaction; other site 997761011938 Metal-binding active site; metal-binding site 997761011939 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761011940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761011941 dimer interface [polypeptide binding]; other site 997761011942 conserved gate region; other site 997761011943 putative PBP binding loops; other site 997761011944 ABC-ATPase subunit interface; other site 997761011945 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761011946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761011947 dimer interface [polypeptide binding]; other site 997761011948 conserved gate region; other site 997761011949 ABC-ATPase subunit interface; other site 997761011950 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761011951 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 997761011952 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761011953 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761011954 Coat F domain; Region: Coat_F; cl17715 997761011955 Protein of unknown function (DUF4025); Region: DUF4025; pfam13217 997761011956 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 997761011957 X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962 997761011958 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 997761011959 homodimer interface [polypeptide binding]; other site 997761011960 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 997761011961 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 997761011962 active site 997761011963 homodimer interface [polypeptide binding]; other site 997761011964 catalytic site [active] 997761011965 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761011966 Interdomain contacts; other site 997761011967 Cytokine receptor motif; other site 997761011968 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 997761011969 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 997761011970 S-layer homology domain; Region: SLH; pfam00395 997761011971 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761011972 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761011973 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761011974 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 997761011975 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 997761011976 LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861 997761011977 nucleotide binding site [chemical binding]; other site 997761011978 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 997761011979 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 997761011980 putative DNA binding site [nucleotide binding]; other site 997761011981 putative homodimer interface [polypeptide binding]; other site 997761011982 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761011983 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761011984 active site 997761011985 catalytic tetrad [active] 997761011986 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 997761011987 Protein of unknown function, DUF393; Region: DUF393; pfam04134 997761011988 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 997761011989 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 997761011990 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 997761011991 dimer interface [polypeptide binding]; other site 997761011992 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761011993 catalytic residue [active] 997761011994 Cache domain; Region: Cache_1; pfam02743 997761011995 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761011996 dimerization interface [polypeptide binding]; other site 997761011997 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761011998 dimer interface [polypeptide binding]; other site 997761011999 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761012000 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761012001 dimer interface [polypeptide binding]; other site 997761012002 putative CheW interface [polypeptide binding]; other site 997761012003 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 997761012004 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 997761012005 active site 997761012006 iron coordination sites [ion binding]; other site 997761012007 substrate binding pocket [chemical binding]; other site 997761012008 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 997761012009 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761012010 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761012011 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761012012 Protein of unknown function (DUF419); Region: DUF419; pfam04237 997761012013 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 997761012014 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 997761012015 NAD binding site [chemical binding]; other site 997761012016 catalytic Zn binding site [ion binding]; other site 997761012017 structural Zn binding site [ion binding]; other site 997761012018 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 997761012019 active site 997761012020 DNA binding site [nucleotide binding] 997761012021 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 997761012022 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 997761012023 dimer interface [polypeptide binding]; other site 997761012024 catalytic triad [active] 997761012025 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 997761012026 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 997761012027 peptide binding site [polypeptide binding]; other site 997761012028 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 997761012029 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 997761012030 Walker A/P-loop; other site 997761012031 ATP binding site [chemical binding]; other site 997761012032 Q-loop/lid; other site 997761012033 ABC transporter signature motif; other site 997761012034 Walker B; other site 997761012035 D-loop; other site 997761012036 H-loop/switch region; other site 997761012037 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 997761012038 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 997761012039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761012040 dimer interface [polypeptide binding]; other site 997761012041 conserved gate region; other site 997761012042 putative PBP binding loops; other site 997761012043 ABC-ATPase subunit interface; other site 997761012044 Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663 997761012045 SxDxEG motif; other site 997761012046 active site 997761012047 metal binding site [ion binding]; metal-binding site 997761012048 homopentamer interface [polypeptide binding]; other site 997761012049 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 997761012050 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 997761012051 putative active site [active] 997761012052 putative NTP binding site [chemical binding]; other site 997761012053 putative nucleic acid binding site [nucleotide binding]; other site 997761012054 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 997761012055 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 997761012056 metal binding site [ion binding]; metal-binding site 997761012057 active site 997761012058 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761012059 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761012060 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761012061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761012062 dimer interface [polypeptide binding]; other site 997761012063 conserved gate region; other site 997761012064 putative PBP binding loops; other site 997761012065 ABC-ATPase subunit interface; other site 997761012066 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761012067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761012068 dimer interface [polypeptide binding]; other site 997761012069 conserved gate region; other site 997761012070 ABC-ATPase subunit interface; other site 997761012071 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761012072 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761012073 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 997761012074 active site 997761012075 catalytic triad [active] 997761012076 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 997761012077 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 997761012078 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761012079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761012080 dimer interface [polypeptide binding]; other site 997761012081 conserved gate region; other site 997761012082 putative PBP binding loops; other site 997761012083 ABC-ATPase subunit interface; other site 997761012084 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761012085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761012086 dimer interface [polypeptide binding]; other site 997761012087 conserved gate region; other site 997761012088 putative PBP binding loops; other site 997761012089 ABC-ATPase subunit interface; other site 997761012090 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 997761012091 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761012092 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761012093 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 997761012094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761012095 active site 997761012096 phosphorylation site [posttranslational modification] 997761012097 intermolecular recognition site; other site 997761012098 dimerization interface [polypeptide binding]; other site 997761012099 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761012100 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761012101 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 997761012102 active site 997761012103 motif I; other site 997761012104 motif II; other site 997761012105 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 997761012106 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 997761012107 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 997761012108 nudix motif; other site 997761012109 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 997761012110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761012111 Coenzyme A binding pocket [chemical binding]; other site 997761012112 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 997761012113 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 997761012114 E-class dimer interface [polypeptide binding]; other site 997761012115 P-class dimer interface [polypeptide binding]; other site 997761012116 active site 997761012117 Cu2+ binding site [ion binding]; other site 997761012118 Zn2+ binding site [ion binding]; other site 997761012119 Protein of unknown function (DUF4023); Region: DUF4023; pfam13215 997761012120 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 997761012121 Predicted membrane protein [Function unknown]; Region: COG2323 997761012122 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 997761012123 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 997761012124 Acyltransferase family; Region: Acyl_transf_3; pfam01757 997761012125 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 997761012126 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 997761012127 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208 997761012128 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 997761012129 NAD binding site [chemical binding]; other site 997761012130 Phe binding site; other site 997761012131 Methyltransferase domain; Region: Methyltransf_31; pfam13847 997761012132 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761012133 S-adenosylmethionine binding site [chemical binding]; other site 997761012134 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 997761012135 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 997761012136 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 997761012137 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 997761012138 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 997761012139 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 997761012140 Walker A/P-loop; other site 997761012141 ATP binding site [chemical binding]; other site 997761012142 Q-loop/lid; other site 997761012143 ABC transporter signature motif; other site 997761012144 Walker B; other site 997761012145 D-loop; other site 997761012146 H-loop/switch region; other site 997761012147 Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785 997761012148 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 997761012149 dimer interface [polypeptide binding]; other site 997761012150 active site 997761012151 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761012152 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 997761012153 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 997761012154 active site 997761012155 Isochorismatase family; Region: Isochorismatase; pfam00857 997761012156 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 997761012157 catalytic triad [active] 997761012158 conserved cis-peptide bond; other site 997761012159 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 997761012160 Part of AAA domain; Region: AAA_19; pfam13245 997761012161 Family description; Region: UvrD_C_2; pfam13538 997761012162 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 997761012163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761012164 Coenzyme A binding pocket [chemical binding]; other site 997761012165 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 997761012166 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761012167 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 997761012168 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 997761012169 Coenzyme A binding pocket [chemical binding]; other site 997761012170 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 997761012171 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 997761012172 HlyD family secretion protein; Region: HlyD_3; pfam13437 997761012173 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 997761012174 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 997761012175 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761012176 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761012177 Walker A/P-loop; other site 997761012178 ATP binding site [chemical binding]; other site 997761012179 Q-loop/lid; other site 997761012180 ABC transporter signature motif; other site 997761012181 Walker B; other site 997761012182 D-loop; other site 997761012183 H-loop/switch region; other site 997761012184 Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723 997761012185 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 997761012186 active site 997761012187 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 997761012188 Putative esterase; Region: Esterase; pfam00756 997761012189 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 997761012190 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 997761012191 Response regulator receiver domain; Region: Response_reg; pfam00072 997761012192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761012193 active site 997761012194 phosphorylation site [posttranslational modification] 997761012195 intermolecular recognition site; other site 997761012196 dimerization interface [polypeptide binding]; other site 997761012197 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761012198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761012199 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761012200 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761012201 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761012202 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761012203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761012204 dimer interface [polypeptide binding]; other site 997761012205 ABC-ATPase subunit interface; other site 997761012206 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761012207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761012208 dimer interface [polypeptide binding]; other site 997761012209 conserved gate region; other site 997761012210 ABC-ATPase subunit interface; other site 997761012211 Protein of unknown function (DUF2536); Region: DUF2536; pfam10750 997761012212 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 997761012213 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761012214 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761012215 dimer interface [polypeptide binding]; other site 997761012216 phosphorylation site [posttranslational modification] 997761012217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761012218 ATP binding site [chemical binding]; other site 997761012219 Mg2+ binding site [ion binding]; other site 997761012220 G-X-G motif; other site 997761012221 VanZ like family; Region: VanZ; pfam04892 997761012222 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761012223 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761012224 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761012225 Spore germination protein; Region: Spore_permease; cl17796 997761012226 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 997761012227 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 997761012228 putative active site [active] 997761012229 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 997761012230 dimer interface [polypeptide binding]; other site 997761012231 active site 997761012232 fructoselysine 3-epimerase; Provisional; Region: PRK09856 997761012233 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 997761012234 Metal-binding active site; metal-binding site 997761012235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761012236 dimer interface [polypeptide binding]; other site 997761012237 conserved gate region; other site 997761012238 putative PBP binding loops; other site 997761012239 ABC-ATPase subunit interface; other site 997761012240 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761012241 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761012242 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 997761012243 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 997761012244 substrate binding site [chemical binding]; other site 997761012245 ATP binding site [chemical binding]; other site 997761012246 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 997761012247 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761012248 DNA-binding site [nucleotide binding]; DNA binding site 997761012249 UTRA domain; Region: UTRA; pfam07702 997761012250 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 997761012251 regulatory protein interface [polypeptide binding]; other site 997761012252 regulatory phosphorylation site [posttranslational modification]; other site 997761012253 Chromate transporter; Region: Chromate_transp; pfam02417 997761012254 Chromate transporter; Region: Chromate_transp; pfam02417 997761012255 YmaF family; Region: YmaF; pfam12788 997761012256 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 997761012257 YtkA-like; Region: YtkA; pfam13115 997761012258 Family description; Region: DsbD_2; pfam13386 997761012259 nickel responsive regulator; Provisional; Region: PRK04460 997761012260 Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383 997761012261 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 997761012262 Predicted membrane protein [Function unknown]; Region: COG4550 997761012263 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 997761012264 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 997761012265 Predicted permease; Region: DUF318; cl17795 997761012266 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761012267 FeS/SAM binding site; other site 997761012268 TRAM domain; Region: TRAM; pfam01938 997761012269 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 997761012270 Propanediol utilisation protein PduL; Region: PduL; pfam06130 997761012271 Propanediol utilisation protein PduL; Region: PduL; pfam06130 997761012272 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 997761012273 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 997761012274 TPP-binding site [chemical binding]; other site 997761012275 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 997761012276 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 997761012277 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 997761012278 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 997761012279 dimer interface [polypeptide binding]; other site 997761012280 PYR/PP interface [polypeptide binding]; other site 997761012281 TPP binding site [chemical binding]; other site 997761012282 substrate binding site [chemical binding]; other site 997761012283 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 997761012284 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 997761012285 active site 997761012286 dimer interface [polypeptide binding]; other site 997761012287 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 997761012288 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 997761012289 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 997761012290 putative active site [active] 997761012291 metal binding site [ion binding]; metal-binding site 997761012292 homodimer binding site [polypeptide binding]; other site 997761012293 phosphodiesterase; Provisional; Region: PRK12704 997761012294 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 997761012295 Zn2+ binding site [ion binding]; other site 997761012296 Mg2+ binding site [ion binding]; other site 997761012297 RecX family; Region: RecX; cl00936 997761012298 recombinase A; Provisional; Region: recA; PRK09354 997761012299 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 997761012300 hexamer interface [polypeptide binding]; other site 997761012301 Walker A motif; other site 997761012302 ATP binding site [chemical binding]; other site 997761012303 Walker B motif; other site 997761012304 competence damage-inducible protein A; Provisional; Region: PRK00549 997761012305 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 997761012306 putative MPT binding site; other site 997761012307 Competence-damaged protein; Region: CinA; pfam02464 997761012308 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560 997761012309 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 997761012310 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 997761012311 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761012312 FeS/SAM binding site; other site 997761012313 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 997761012314 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761012315 non-specific DNA binding site [nucleotide binding]; other site 997761012316 salt bridge; other site 997761012317 sequence-specific DNA binding site [nucleotide binding]; other site 997761012318 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 997761012319 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 997761012320 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 997761012321 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 997761012322 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 997761012323 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761012324 NAD(P) binding site [chemical binding]; other site 997761012325 active site 997761012326 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 997761012327 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 997761012328 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 997761012329 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 997761012330 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 997761012331 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 997761012332 YlzJ-like protein; Region: YlzJ; pfam14035 997761012333 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 997761012334 active site 997761012335 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 997761012336 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 997761012337 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 997761012338 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 997761012339 dihydrodipicolinate synthase; Region: dapA; TIGR00674 997761012340 dimer interface [polypeptide binding]; other site 997761012341 active site 997761012342 catalytic residue [active] 997761012343 aspartate kinase I; Reviewed; Region: PRK08210 997761012344 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 997761012345 nucleotide binding site [chemical binding]; other site 997761012346 substrate binding site [chemical binding]; other site 997761012347 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 997761012348 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 997761012349 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 997761012350 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 997761012351 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 997761012352 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 997761012353 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 997761012354 NAD binding site [chemical binding]; other site 997761012355 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 997761012356 trimer interface [polypeptide binding]; other site 997761012357 active site 997761012358 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 997761012359 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 997761012360 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 997761012361 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 997761012362 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 997761012363 NodB motif; other site 997761012364 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 997761012365 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 997761012366 RNase E interface [polypeptide binding]; other site 997761012367 trimer interface [polypeptide binding]; other site 997761012368 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 997761012369 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 997761012370 RNase E interface [polypeptide binding]; other site 997761012371 trimer interface [polypeptide binding]; other site 997761012372 active site 997761012373 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 997761012374 putative nucleic acid binding region [nucleotide binding]; other site 997761012375 G-X-X-G motif; other site 997761012376 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 997761012377 RNA binding site [nucleotide binding]; other site 997761012378 domain interface; other site 997761012379 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 997761012380 16S/18S rRNA binding site [nucleotide binding]; other site 997761012381 S13e-L30e interaction site [polypeptide binding]; other site 997761012382 25S rRNA binding site [nucleotide binding]; other site 997761012383 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 997761012384 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 997761012385 active site 997761012386 Riboflavin kinase; Region: Flavokinase; pfam01687 997761012387 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 997761012388 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 997761012389 RNA binding site [nucleotide binding]; other site 997761012390 active site 997761012391 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 997761012392 DHH family; Region: DHH; pfam01368 997761012393 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 997761012394 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 997761012395 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 997761012396 putative RNA binding cleft [nucleotide binding]; other site 997761012397 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 997761012398 NusA N-terminal domain; Region: NusA_N; pfam08529 997761012399 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 997761012400 RNA binding site [nucleotide binding]; other site 997761012401 homodimer interface [polypeptide binding]; other site 997761012402 NusA-like KH domain; Region: KH_5; pfam13184 997761012403 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 997761012404 G-X-X-G motif; other site 997761012405 ribosome maturation protein RimP; Reviewed; Region: PRK00092 997761012406 Sm and related proteins; Region: Sm_like; cl00259 997761012407 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 997761012408 putative oligomer interface [polypeptide binding]; other site 997761012409 putative RNA binding site [nucleotide binding]; other site 997761012410 DNA polymerase III PolC; Validated; Region: polC; PRK00448 997761012411 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 997761012412 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 997761012413 generic binding surface I; other site 997761012414 generic binding surface II; other site 997761012415 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 997761012416 active site 997761012417 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 997761012418 active site 997761012419 catalytic site [active] 997761012420 substrate binding site [chemical binding]; other site 997761012421 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 997761012422 prolyl-tRNA synthetase; Provisional; Region: PRK08661 997761012423 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 997761012424 dimer interface [polypeptide binding]; other site 997761012425 motif 1; other site 997761012426 active site 997761012427 motif 2; other site 997761012428 motif 3; other site 997761012429 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 997761012430 anticodon binding site; other site 997761012431 zinc-binding site [ion binding]; other site 997761012432 RIP metalloprotease RseP; Region: TIGR00054 997761012433 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 997761012434 active site 997761012435 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 997761012436 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 997761012437 protein binding site [polypeptide binding]; other site 997761012438 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 997761012439 putative substrate binding region [chemical binding]; other site 997761012440 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 997761012441 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 997761012442 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 997761012443 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 997761012444 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 997761012445 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 997761012446 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830 997761012447 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 997761012448 catalytic residue [active] 997761012449 putative FPP diphosphate binding site; other site 997761012450 putative FPP binding hydrophobic cleft; other site 997761012451 dimer interface [polypeptide binding]; other site 997761012452 putative IPP diphosphate binding site; other site 997761012453 ribosome recycling factor; Reviewed; Region: frr; PRK00083 997761012454 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 997761012455 hinge region; other site 997761012456 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 997761012457 putative nucleotide binding site [chemical binding]; other site 997761012458 uridine monophosphate binding site [chemical binding]; other site 997761012459 homohexameric interface [polypeptide binding]; other site 997761012460 elongation factor Ts; Reviewed; Region: tsf; PRK12332 997761012461 UBA/TS-N domain; Region: UBA; pfam00627 997761012462 Elongation factor TS; Region: EF_TS; pfam00889 997761012463 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 997761012464 rRNA interaction site [nucleotide binding]; other site 997761012465 S8 interaction site; other site 997761012466 putative laminin-1 binding site; other site 997761012467 YceG-like family; Region: YceG; pfam02618 997761012468 Protein of unknown function (DUF342); Region: DUF342; pfam03961 997761012469 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 997761012470 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761012471 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 997761012472 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761012473 DNA binding residues [nucleotide binding] 997761012474 heterogeneous nuclear ribonucleoprotein R, Q family; Region: hnRNP-R-Q; TIGR01648 997761012475 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 997761012476 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 997761012477 CheC-like family; Region: CheC; pfam04509 997761012478 CheC-like family; Region: CheC; pfam04509 997761012479 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 997761012480 putative CheA interaction surface; other site 997761012481 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 997761012482 putative binding surface; other site 997761012483 active site 997761012484 P2 response regulator binding domain; Region: P2; pfam07194 997761012485 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 997761012486 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 997761012487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761012488 ATP binding site [chemical binding]; other site 997761012489 Mg2+ binding site [ion binding]; other site 997761012490 G-X-G motif; other site 997761012491 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 997761012492 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 997761012493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761012494 active site 997761012495 phosphorylation site [posttranslational modification] 997761012496 intermolecular recognition site; other site 997761012497 dimerization interface [polypeptide binding]; other site 997761012498 CheB methylesterase; Region: CheB_methylest; pfam01339 997761012499 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 997761012500 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 997761012501 P-loop; other site 997761012502 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 997761012503 FHIPEP family; Region: FHIPEP; pfam00771 997761012504 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 997761012505 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 997761012506 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 997761012507 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 997761012508 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 997761012509 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 997761012510 Response regulator receiver domain; Region: Response_reg; pfam00072 997761012511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761012512 active site 997761012513 phosphorylation site [posttranslational modification] 997761012514 intermolecular recognition site; other site 997761012515 dimerization interface [polypeptide binding]; other site 997761012516 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 997761012517 CheC-like family; Region: CheC; pfam04509 997761012518 CheC-like family; Region: CheC; pfam04509 997761012519 flagellar motor switch protein FliN; Region: fliN; TIGR02480 997761012520 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 997761012521 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 997761012522 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718 997761012523 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 997761012524 Flagellar protein (FlbD); Region: FlbD; pfam06289 997761012525 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 997761012526 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 997761012527 Class I aldolases; Region: Aldolase_Class_I; cl17187 997761012528 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 997761012529 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 997761012530 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 997761012531 Uncharacterized conserved protein [Function unknown]; Region: COG3334 997761012532 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 997761012533 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 997761012534 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 997761012535 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 997761012536 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 997761012537 Walker A motif/ATP binding site; other site 997761012538 Walker B motif; other site 997761012539 flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825 997761012540 Flagellar assembly protein FliH; Region: FliH; pfam02108 997761012541 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 997761012542 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 997761012543 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 997761012544 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 997761012545 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 997761012546 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 997761012547 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 997761012548 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 997761012549 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761012550 Walker A motif; other site 997761012551 ATP binding site [chemical binding]; other site 997761012552 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 997761012553 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 997761012554 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 997761012555 active site 997761012556 HslU subunit interaction site [polypeptide binding]; other site 997761012557 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 997761012558 Glucose inhibited division protein A; Region: GIDA; pfam01134 997761012559 DNA topoisomerase I; Validated; Region: PRK05582 997761012560 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 997761012561 active site 997761012562 interdomain interaction site; other site 997761012563 putative metal-binding site [ion binding]; other site 997761012564 nucleotide binding site [chemical binding]; other site 997761012565 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 997761012566 domain I; other site 997761012567 DNA binding groove [nucleotide binding] 997761012568 phosphate binding site [ion binding]; other site 997761012569 domain II; other site 997761012570 domain III; other site 997761012571 nucleotide binding site [chemical binding]; other site 997761012572 catalytic site [active] 997761012573 domain IV; other site 997761012574 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 997761012575 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 997761012576 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 997761012577 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 997761012578 DNA protecting protein DprA; Region: dprA; TIGR00732 997761012579 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 997761012580 CoA binding domain; Region: CoA_binding; smart00881 997761012581 CoA-ligase; Region: Ligase_CoA; pfam00549 997761012582 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 997761012583 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 997761012584 CoA-ligase; Region: Ligase_CoA; pfam00549 997761012585 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 997761012586 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 997761012587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761012588 Walker A motif; other site 997761012589 ATP binding site [chemical binding]; other site 997761012590 Walker B motif; other site 997761012591 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 997761012592 hypothetical protein; Reviewed; Region: PRK12497 997761012593 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 997761012594 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 997761012595 RNA/DNA hybrid binding site [nucleotide binding]; other site 997761012596 active site 997761012597 Uncharacterized conserved protein [Function unknown]; Region: COG1434 997761012598 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 997761012599 putative active site [active] 997761012600 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 997761012601 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 997761012602 GTP/Mg2+ binding site [chemical binding]; other site 997761012603 G4 box; other site 997761012604 G5 box; other site 997761012605 G1 box; other site 997761012606 Switch I region; other site 997761012607 G2 box; other site 997761012608 G3 box; other site 997761012609 Switch II region; other site 997761012610 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 997761012611 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 997761012612 Catalytic site [active] 997761012613 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 997761012614 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 997761012615 CARDB; Region: CARDB; pfam07705 997761012616 S-layer homology domain; Region: SLH; pfam00395 997761012617 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 997761012618 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 997761012619 RimM N-terminal domain; Region: RimM; pfam01782 997761012620 PRC-barrel domain; Region: PRC; pfam05239 997761012621 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 997761012622 hypothetical protein; Provisional; Region: PRK00468 997761012623 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 997761012624 signal recognition particle protein; Provisional; Region: PRK10867 997761012625 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 997761012626 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 997761012627 P loop; other site 997761012628 GTP binding site [chemical binding]; other site 997761012629 Signal peptide binding domain; Region: SRP_SPB; pfam02978 997761012630 putative DNA-binding protein; Validated; Region: PRK00118 997761012631 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 997761012632 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 997761012633 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 997761012634 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 997761012635 P loop; other site 997761012636 GTP binding site [chemical binding]; other site 997761012637 ribonuclease III; Reviewed; Region: rnc; PRK00102 997761012638 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 997761012639 dimerization interface [polypeptide binding]; other site 997761012640 active site 997761012641 metal binding site [ion binding]; metal-binding site 997761012642 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 997761012643 dsRNA binding site [nucleotide binding]; other site 997761012644 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 997761012645 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 997761012646 dimer interface [polypeptide binding]; other site 997761012647 active site 997761012648 acyl carrier protein; Provisional; Region: acpP; PRK00982 997761012649 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 997761012650 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 997761012651 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 997761012652 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 997761012653 dimer interface [polypeptide binding]; other site 997761012654 active site 997761012655 CoA binding pocket [chemical binding]; other site 997761012656 putative phosphate acyltransferase; Provisional; Region: PRK05331 997761012657 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 997761012658 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 997761012659 active site 2 [active] 997761012660 active site 1 [active] 997761012661 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 997761012662 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 997761012663 hypothetical protein; Provisional; Region: PRK13670 997761012664 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 997761012665 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 997761012666 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 997761012667 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 997761012668 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 997761012669 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 997761012670 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 997761012671 active site 997761012672 (T/H)XGH motif; other site 997761012673 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 997761012674 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761012675 S-adenosylmethionine binding site [chemical binding]; other site 997761012676 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 997761012677 Uncharacterized conserved protein [Function unknown]; Region: COG1284 997761012678 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 997761012679 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 997761012680 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 997761012681 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 997761012682 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 997761012683 Glycosyl hydrolase family 43; Region: GH43_4; cd08983 997761012684 active site 997761012685 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 997761012686 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 997761012687 RDD family; Region: RDD; pfam06271 997761012688 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 997761012689 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761012690 putative metal binding site [ion binding]; other site 997761012691 Predicted membrane protein [Function unknown]; Region: COG3766 997761012692 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 997761012693 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 997761012694 Glucuronate isomerase; Region: UxaC; pfam02614 997761012695 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 997761012696 DNA polymerase IV; Reviewed; Region: PRK03103 997761012697 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 997761012698 active site 997761012699 DNA binding site [nucleotide binding] 997761012700 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 997761012701 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 997761012702 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 997761012703 Right handed beta helix region; Region: Beta_helix; pfam13229 997761012704 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 997761012705 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761012706 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761012707 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 997761012708 EDD domain protein, DegV family; Region: DegV; TIGR00762 997761012709 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 997761012710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 997761012711 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 997761012712 Stage V sporulation protein family; Region: SpoV; cl15455 997761012713 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 997761012714 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 997761012715 substrate binding site [chemical binding]; other site 997761012716 hexamer interface [polypeptide binding]; other site 997761012717 metal binding site [ion binding]; metal-binding site 997761012718 GTPase RsgA; Reviewed; Region: PRK00098 997761012719 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 997761012720 RNA binding site [nucleotide binding]; other site 997761012721 homodimer interface [polypeptide binding]; other site 997761012722 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 997761012723 GTPase/Zn-binding domain interface [polypeptide binding]; other site 997761012724 GTP/Mg2+ binding site [chemical binding]; other site 997761012725 G4 box; other site 997761012726 G5 box; other site 997761012727 G1 box; other site 997761012728 Switch I region; other site 997761012729 G2 box; other site 997761012730 G3 box; other site 997761012731 Switch II region; other site 997761012732 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 997761012733 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 997761012734 active site 997761012735 ATP binding site [chemical binding]; other site 997761012736 substrate binding site [chemical binding]; other site 997761012737 activation loop (A-loop); other site 997761012738 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 997761012739 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 997761012740 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 997761012741 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 997761012742 active site 997761012743 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 997761012744 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761012745 FeS/SAM binding site; other site 997761012746 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 997761012747 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 997761012748 putative active site [active] 997761012749 substrate binding site [chemical binding]; other site 997761012750 putative cosubstrate binding site; other site 997761012751 catalytic site [active] 997761012752 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 997761012753 substrate binding site [chemical binding]; other site 997761012754 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 997761012755 active site 997761012756 catalytic residues [active] 997761012757 metal binding site [ion binding]; metal-binding site 997761012758 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 997761012759 primosomal protein N' Region: priA; TIGR00595 997761012760 ATP binding site [chemical binding]; other site 997761012761 putative Mg++ binding site [ion binding]; other site 997761012762 helicase superfamily c-terminal domain; Region: HELICc; smart00490 997761012763 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 997761012764 Flavoprotein; Region: Flavoprotein; pfam02441 997761012765 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 997761012766 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 997761012767 hypothetical protein; Provisional; Region: PRK04323 997761012768 hypothetical protein; Provisional; Region: PRK11820 997761012769 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 997761012770 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 997761012771 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 997761012772 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 997761012773 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 997761012774 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 997761012775 Domain of unknown function (DUF814); Region: DUF814; pfam05670 997761012776 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 997761012777 CheB methylesterase; Region: CheB_methylest; pfam01339 997761012778 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 997761012779 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 997761012780 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 997761012781 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473 997761012782 PAS domain; Region: PAS_10; pfam13596 997761012783 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 997761012784 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761012785 putative active site [active] 997761012786 heme pocket [chemical binding]; other site 997761012787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761012788 dimer interface [polypeptide binding]; other site 997761012789 phosphorylation site [posttranslational modification] 997761012790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761012791 ATP binding site [chemical binding]; other site 997761012792 Mg2+ binding site [ion binding]; other site 997761012793 G-X-G motif; other site 997761012794 B12 binding domain; Region: B12-binding_2; pfam02607 997761012795 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 997761012796 B12 binding site [chemical binding]; other site 997761012797 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 997761012798 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 997761012799 active site 997761012800 tetramer interface; other site 997761012801 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 997761012802 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 997761012803 active site 997761012804 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 997761012805 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761012806 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761012807 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 997761012808 putative dimerization interface [polypeptide binding]; other site 997761012809 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 997761012810 L-asparaginase II; Region: Asparaginase_II; pfam06089 997761012811 Protein of unknown function (DUF964); Region: DUF964; pfam06133 997761012812 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 997761012813 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 997761012814 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 997761012815 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 997761012816 ATP binding site [chemical binding]; other site 997761012817 putative Mg++ binding site [ion binding]; other site 997761012818 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 997761012819 nucleotide binding region [chemical binding]; other site 997761012820 ATP-binding site [chemical binding]; other site 997761012821 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 997761012822 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 997761012823 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 997761012824 active site 997761012825 HIGH motif; other site 997761012826 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 997761012827 tRNA binding surface [nucleotide binding]; other site 997761012828 anticodon binding site; other site 997761012829 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761012830 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761012831 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761012832 FOG: CBS domain [General function prediction only]; Region: COG0517 997761012833 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 997761012834 YugN-like family; Region: YugN; pfam08868 997761012835 Asp23 family; Region: Asp23; pfam03780 997761012836 calcium/proton exchanger (cax); Region: cax; TIGR00378 997761012837 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 997761012838 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 997761012839 hypothetical protein; Provisional; Region: PRK13666 997761012840 PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381 997761012841 regulatory protein interface [polypeptide binding]; other site 997761012842 regulatory phosphorylation site [posttranslational modification]; other site 997761012843 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 997761012844 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 997761012845 Uncharacterized conserved protein [Function unknown]; Region: COG0398 997761012846 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 997761012847 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 997761012848 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 997761012849 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 997761012850 RNA binding surface [nucleotide binding]; other site 997761012851 acetyl-CoA synthetase; Provisional; Region: PRK04319 997761012852 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 997761012853 Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969 997761012854 active site 997761012855 acyl-activating enzyme (AAE) consensus motif; other site 997761012856 putative CoA binding site [chemical binding]; other site 997761012857 AMP binding site [chemical binding]; other site 997761012858 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 997761012859 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 997761012860 active site 997761012861 Zn binding site [ion binding]; other site 997761012862 glycyl-tRNA synthetase; Provisional; Region: PRK04173 997761012863 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 997761012864 motif 1; other site 997761012865 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 997761012866 active site 997761012867 motif 2; other site 997761012868 motif 3; other site 997761012869 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 997761012870 anticodon binding site; other site 997761012871 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 997761012872 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 997761012873 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 997761012874 intracellular protease, PfpI family; Region: PfpI; TIGR01382 997761012875 proposed catalytic triad [active] 997761012876 conserved cys residue [active] 997761012877 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 997761012878 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 997761012879 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 997761012880 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 997761012881 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 997761012882 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 997761012883 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 997761012884 active site turn [active] 997761012885 phosphorylation site [posttranslational modification] 997761012886 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 997761012887 HPr interaction site; other site 997761012888 glycerol kinase (GK) interaction site [polypeptide binding]; other site 997761012889 active site 997761012890 phosphorylation site [posttranslational modification] 997761012891 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 997761012892 thiamine phosphate binding site [chemical binding]; other site 997761012893 active site 997761012894 pyrophosphate binding site [ion binding]; other site 997761012895 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 997761012896 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 997761012897 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 997761012898 hinge; other site 997761012899 active site 997761012900 CrcB-like protein; Region: CRCB; cl09114 997761012901 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 997761012902 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 997761012903 active site residue [active] 997761012904 shikimate kinase; Reviewed; Region: aroK; PRK00131 997761012905 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 997761012906 ADP binding site [chemical binding]; other site 997761012907 magnesium binding site [ion binding]; other site 997761012908 putative shikimate binding site; other site 997761012909 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 997761012910 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 997761012911 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 997761012912 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 997761012913 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 997761012914 N- and C-terminal domain interface [polypeptide binding]; other site 997761012915 active site 997761012916 catalytic site [active] 997761012917 metal binding site [ion binding]; metal-binding site 997761012918 carbohydrate binding site [chemical binding]; other site 997761012919 ATP binding site [chemical binding]; other site 997761012920 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 997761012921 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761012922 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761012923 DNA binding site [nucleotide binding] 997761012924 domain linker motif; other site 997761012925 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 997761012926 dimerization interface [polypeptide binding]; other site 997761012927 ligand binding site [chemical binding]; other site 997761012928 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 997761012929 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 997761012930 active site 997761012931 Na/Ca binding site [ion binding]; other site 997761012932 catalytic site [active] 997761012933 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 997761012934 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761012935 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 997761012936 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 997761012937 active site 997761012938 catalytic triad [active] 997761012939 oxyanion hole [active] 997761012940 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761012941 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761012942 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761012943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761012944 dimer interface [polypeptide binding]; other site 997761012945 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761012946 ABC-ATPase subunit interface; other site 997761012947 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761012948 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761012949 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761012950 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761012951 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 997761012952 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 997761012953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761012954 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761012955 putative substrate translocation pore; other site 997761012956 NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512 997761012957 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761012958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761012959 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 997761012960 active site 997761012961 motif I; other site 997761012962 motif II; other site 997761012963 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761012964 Domain of unknown function (DUF1885); Region: DUF1885; pfam08968 997761012965 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 997761012966 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761012967 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 997761012968 Arginase family; Region: Arginase; cd09989 997761012969 active site 997761012970 Mn binding site [ion binding]; other site 997761012971 oligomer interface [polypeptide binding]; other site 997761012972 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 997761012973 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 997761012974 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 997761012975 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761012976 dimerization interface [polypeptide binding]; other site 997761012977 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761012978 dimer interface [polypeptide binding]; other site 997761012979 putative CheW interface [polypeptide binding]; other site 997761012980 Divergent PAP2 family; Region: DUF212; pfam02681 997761012981 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 997761012982 GTP binding site; other site 997761012983 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 997761012984 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 997761012985 ligand binding site [chemical binding]; other site 997761012986 flexible hinge region; other site 997761012987 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 997761012988 putative switch regulator; other site 997761012989 non-specific DNA interactions [nucleotide binding]; other site 997761012990 DNA binding site [nucleotide binding] 997761012991 sequence specific DNA binding site [nucleotide binding]; other site 997761012992 putative cAMP binding site [chemical binding]; other site 997761012993 Protein of unknown function (DUF1811); Region: DUF1811; pfam08838 997761012994 PilZ domain; Region: PilZ; pfam07238 997761012995 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 997761012996 active site 997761012997 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 997761012998 DNA binding site [nucleotide binding] 997761012999 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 997761013000 DNA binding site [nucleotide binding] 997761013001 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 997761013002 putative deacylase active site [active] 997761013003 Domain of unknown function (DUF3973); Region: DUF3973; pfam13119 997761013004 WYL domain; Region: WYL; cl14852 997761013005 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 997761013006 Spore germination protein GerPC; Region: GerPC; pfam10737 997761013007 Protein of unknown function (DUF2539); Region: DUF2539; pfam10803 997761013008 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 997761013009 Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676 997761013010 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 997761013011 tetramer interfaces [polypeptide binding]; other site 997761013012 binuclear metal-binding site [ion binding]; other site 997761013013 hypothetical protein; Provisional; Region: PRK13679 997761013014 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 997761013015 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 997761013016 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 997761013017 HlyD family secretion protein; Region: HlyD_3; pfam13437 997761013018 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 997761013019 Protein export membrane protein; Region: SecD_SecF; cl14618 997761013020 Protein export membrane protein; Region: SecD_SecF; cl14618 997761013021 Predicted transcriptional regulators [Transcription]; Region: COG1510 997761013022 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761013023 putative DNA binding site [nucleotide binding]; other site 997761013024 putative Zn2+ binding site [ion binding]; other site 997761013025 Domain of unknown function (DUF4166); Region: DUF4166; pfam13761 997761013026 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761013027 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761013028 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 997761013029 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 997761013030 Walker A/P-loop; other site 997761013031 ATP binding site [chemical binding]; other site 997761013032 Q-loop/lid; other site 997761013033 ABC transporter signature motif; other site 997761013034 Walker B; other site 997761013035 D-loop; other site 997761013036 H-loop/switch region; other site 997761013037 FtsX-like permease family; Region: FtsX; pfam02687 997761013038 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761013039 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761013040 dimer interface [polypeptide binding]; other site 997761013041 putative CheW interface [polypeptide binding]; other site 997761013042 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 997761013043 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 997761013044 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 997761013045 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 997761013046 putative dimer interface [polypeptide binding]; other site 997761013047 putative anticodon binding site; other site 997761013048 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 997761013049 homodimer interface [polypeptide binding]; other site 997761013050 motif 1; other site 997761013051 motif 2; other site 997761013052 active site 997761013053 motif 3; other site 997761013054 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 997761013055 propionate/acetate kinase; Provisional; Region: PRK12379 997761013056 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 997761013057 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 997761013058 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 997761013059 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 997761013060 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 997761013061 substrate binding site [chemical binding]; other site 997761013062 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 997761013063 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 997761013064 substrate binding site [chemical binding]; other site 997761013065 ligand binding site [chemical binding]; other site 997761013066 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761013067 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761013068 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761013069 dimerization interface [polypeptide binding]; other site 997761013070 Predicted amidohydrolase [General function prediction only]; Region: COG0388 997761013071 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 997761013072 putative active site [active] 997761013073 catalytic triad [active] 997761013074 putative dimer interface [polypeptide binding]; other site 997761013075 transaminase; Reviewed; Region: PRK08068 997761013076 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761013077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761013078 homodimer interface [polypeptide binding]; other site 997761013079 catalytic residue [active] 997761013080 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 997761013081 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 997761013082 putative catalytic cysteine [active] 997761013083 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 997761013084 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 997761013085 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 997761013086 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 997761013087 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 997761013088 intersubunit interface [polypeptide binding]; other site 997761013089 active site 997761013090 Zn2+ binding site [ion binding]; other site 997761013091 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 997761013092 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 997761013093 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 997761013094 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 997761013095 Walker A/P-loop; other site 997761013096 ATP binding site [chemical binding]; other site 997761013097 Q-loop/lid; other site 997761013098 ABC transporter signature motif; other site 997761013099 Walker B; other site 997761013100 D-loop; other site 997761013101 H-loop/switch region; other site 997761013102 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 997761013103 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761013104 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761013105 DNA binding residues [nucleotide binding] 997761013106 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 997761013107 active site 997761013108 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 997761013109 active site 997761013110 dimer interface [polypeptide binding]; other site 997761013111 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 997761013112 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 997761013113 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 997761013114 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 997761013115 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 997761013116 ATP-grasp domain; Region: ATP-grasp_4; cl17255 997761013117 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 997761013118 IMP binding site; other site 997761013119 dimer interface [polypeptide binding]; other site 997761013120 interdomain contacts; other site 997761013121 partial ornithine binding site; other site 997761013122 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 997761013123 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 997761013124 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 997761013125 catalytic site [active] 997761013126 subunit interface [polypeptide binding]; other site 997761013127 dihydroorotase; Validated; Region: pyrC; PRK09357 997761013128 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 997761013129 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 997761013130 active site 997761013131 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 997761013132 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 997761013133 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 997761013134 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 997761013135 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 997761013136 active site 997761013137 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 997761013138 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 997761013139 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 997761013140 putative trimer interface [polypeptide binding]; other site 997761013141 putative CoA binding site [chemical binding]; other site 997761013142 aminotransferase A; Validated; Region: PRK07683 997761013143 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761013144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761013145 homodimer interface [polypeptide binding]; other site 997761013146 catalytic residue [active] 997761013147 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 997761013148 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 997761013149 RNA binding surface [nucleotide binding]; other site 997761013150 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 997761013151 active site 997761013152 lipoprotein signal peptidase; Provisional; Region: PRK14787 997761013153 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 997761013154 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 997761013155 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 997761013156 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 997761013157 HIGH motif; other site 997761013158 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 997761013159 active site 997761013160 KMSKS motif; other site 997761013161 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 997761013162 tRNA binding surface [nucleotide binding]; other site 997761013163 anticodon binding site; other site 997761013164 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 997761013165 DivIVA protein; Region: DivIVA; pfam05103 997761013166 DivIVA domain; Region: DivI1A_domain; TIGR03544 997761013167 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 997761013168 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 997761013169 RNA binding surface [nucleotide binding]; other site 997761013170 YGGT family; Region: YGGT; pfam02325 997761013171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 997761013172 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 997761013173 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 997761013174 catalytic residue [active] 997761013175 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 997761013176 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 997761013177 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 997761013178 sporulation sigma factor SigG; Reviewed; Region: PRK08215 997761013179 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761013180 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 997761013181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761013182 DNA binding residues [nucleotide binding] 997761013183 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 997761013184 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 997761013185 cell division protein FtsZ; Validated; Region: PRK09330 997761013186 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 997761013187 nucleotide binding site [chemical binding]; other site 997761013188 SulA interaction site; other site 997761013189 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 997761013190 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 997761013191 nucleotide binding site [chemical binding]; other site 997761013192 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 997761013193 Cell division protein FtsA; Region: FtsA; pfam14450 997761013194 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 997761013195 Cell division protein FtsQ; Region: FtsQ; pfam03799 997761013196 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 997761013197 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 997761013198 hinge; other site 997761013199 active site 997761013200 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 997761013201 FAD binding domain; Region: FAD_binding_4; pfam01565 997761013202 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 997761013203 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 997761013204 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 997761013205 active site 997761013206 homodimer interface [polypeptide binding]; other site 997761013207 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 997761013208 TrkA-N domain; Region: TrkA_N; pfam02254 997761013209 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 997761013210 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 997761013211 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 997761013212 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 997761013213 Mg++ binding site [ion binding]; other site 997761013214 putative catalytic motif [active] 997761013215 putative substrate binding site [chemical binding]; other site 997761013216 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 997761013217 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 997761013218 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 997761013219 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 997761013220 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 997761013221 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 997761013222 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 997761013223 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 997761013224 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 997761013225 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 997761013226 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 997761013227 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 997761013228 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 997761013229 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 997761013230 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 997761013231 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 997761013232 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 997761013233 Cell division protein FtsL; Region: FtsL; cl11433 997761013234 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 997761013235 MraW methylase family; Region: Methyltransf_5; pfam01795 997761013236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 997761013237 MraZ protein; Region: MraZ; pfam02381 997761013238 MraZ protein; Region: MraZ; pfam02381 997761013239 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 997761013240 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 997761013241 homotetramer interface [polypeptide binding]; other site 997761013242 ligand binding site [chemical binding]; other site 997761013243 catalytic site [active] 997761013244 NAD binding site [chemical binding]; other site 997761013245 Protein of unknown function (DUF4085); Region: DUF4085; pfam13315 997761013246 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 997761013247 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 997761013248 Walker A/P-loop; other site 997761013249 ATP binding site [chemical binding]; other site 997761013250 Q-loop/lid; other site 997761013251 ABC transporter signature motif; other site 997761013252 Walker B; other site 997761013253 D-loop; other site 997761013254 H-loop/switch region; other site 997761013255 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 997761013256 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 997761013257 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 997761013258 Walker A/P-loop; other site 997761013259 ATP binding site [chemical binding]; other site 997761013260 Q-loop/lid; other site 997761013261 ABC transporter signature motif; other site 997761013262 Walker B; other site 997761013263 D-loop; other site 997761013264 H-loop/switch region; other site 997761013265 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 997761013266 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 997761013267 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 997761013268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761013269 dimer interface [polypeptide binding]; other site 997761013270 conserved gate region; other site 997761013271 putative PBP binding loops; other site 997761013272 ABC-ATPase subunit interface; other site 997761013273 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 997761013274 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761013275 dimer interface [polypeptide binding]; other site 997761013276 conserved gate region; other site 997761013277 putative PBP binding loops; other site 997761013278 ABC-ATPase subunit interface; other site 997761013279 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 997761013280 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 997761013281 peptide binding site [polypeptide binding]; other site 997761013282 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 997761013283 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 997761013284 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 997761013285 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 997761013286 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 997761013287 Protein of unknown function (DUF2626); Region: DUF2626; pfam11117 997761013288 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 997761013289 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 997761013290 putative active site [active] 997761013291 PhoH-like protein; Region: PhoH; pfam02562 997761013292 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 997761013293 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 997761013294 YlaH-like protein; Region: YlaH; pfam14036 997761013295 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 997761013296 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 997761013297 G1 box; other site 997761013298 putative GEF interaction site [polypeptide binding]; other site 997761013299 GTP/Mg2+ binding site [chemical binding]; other site 997761013300 Switch I region; other site 997761013301 G2 box; other site 997761013302 G3 box; other site 997761013303 Switch II region; other site 997761013304 G4 box; other site 997761013305 G5 box; other site 997761013306 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 997761013307 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 997761013308 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 997761013309 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 997761013310 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 997761013311 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 997761013312 Ligand Binding Site [chemical binding]; other site 997761013313 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 997761013314 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 997761013315 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 997761013316 catalytic residue [active] 997761013317 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 997761013318 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 997761013319 N-acetyl-D-glucosamine binding site [chemical binding]; other site 997761013320 catalytic residue [active] 997761013321 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 997761013322 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 997761013323 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 997761013324 active site 997761013325 catalytic triad [active] 997761013326 Uncharacterized conserved protein [Function unknown]; Region: COG0327 997761013327 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 997761013328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 997761013329 Uncharacterized conserved protein [Function unknown]; Region: COG0327 997761013330 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 997761013331 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 997761013332 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 997761013333 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 997761013334 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761013335 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 997761013336 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761013337 DNA binding residues [nucleotide binding] 997761013338 DNA primase; Validated; Region: dnaG; PRK05667 997761013339 CHC2 zinc finger; Region: zf-CHC2; pfam01807 997761013340 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 997761013341 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 997761013342 active site 997761013343 metal binding site [ion binding]; metal-binding site 997761013344 interdomain interaction site; other site 997761013345 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 997761013346 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 997761013347 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 997761013348 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 997761013349 Recombination protein O N terminal; Region: RecO_N; pfam11967 997761013350 Recombination protein O C terminal; Region: RecO_C; pfam02565 997761013351 YqzL-like protein; Region: YqzL; pfam14006 997761013352 GTPase Era; Reviewed; Region: era; PRK00089 997761013353 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 997761013354 G1 box; other site 997761013355 GTP/Mg2+ binding site [chemical binding]; other site 997761013356 Switch I region; other site 997761013357 G2 box; other site 997761013358 Switch II region; other site 997761013359 G3 box; other site 997761013360 G4 box; other site 997761013361 G5 box; other site 997761013362 KH domain; Region: KH_2; pfam07650 997761013363 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 997761013364 active site 997761013365 catalytic motif [active] 997761013366 Zn binding site [ion binding]; other site 997761013367 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 997761013368 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 997761013369 active site 997761013370 metal-binding heat shock protein; Provisional; Region: PRK00016 997761013371 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 997761013372 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 997761013373 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 997761013374 Zn2+ binding site [ion binding]; other site 997761013375 Mg2+ binding site [ion binding]; other site 997761013376 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 997761013377 PhoH-like protein; Region: PhoH; pfam02562 997761013378 YabP family; Region: YabP; cl06766 997761013379 hypothetical protein; Provisional; Region: PRK13665 997761013380 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 997761013381 active site residues [active] 997761013382 dimer interface [polypeptide binding]; other site 997761013383 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 997761013384 Yqey-like protein; Region: YqeY; pfam09424 997761013385 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 997761013386 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 997761013387 nucleotide binding site/active site [active] 997761013388 HIT family signature motif; other site 997761013389 catalytic residue [active] 997761013390 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761013391 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761013392 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 997761013393 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 997761013394 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 997761013395 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 997761013396 active site 997761013397 metal binding site [ion binding]; metal-binding site 997761013398 DNA binding site [nucleotide binding] 997761013399 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 997761013400 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 997761013401 Part of AAA domain; Region: AAA_19; pfam13245 997761013402 Family description; Region: UvrD_C_2; pfam13538 997761013403 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 997761013404 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 997761013405 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 997761013406 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 997761013407 putative FMN binding site [chemical binding]; other site 997761013408 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 997761013409 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 997761013410 putative RNA binding site [nucleotide binding]; other site 997761013411 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761013412 S-adenosylmethionine binding site [chemical binding]; other site 997761013413 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 997761013414 active site 997761013415 Ap6A binding site [chemical binding]; other site 997761013416 nudix motif; other site 997761013417 metal binding site [ion binding]; metal-binding site 997761013418 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 997761013419 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 997761013420 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761013421 FeS/SAM binding site; other site 997761013422 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 997761013423 RNA methyltransferase, RsmE family; Region: TIGR00046 997761013424 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 997761013425 Peptidase family M50; Region: Peptidase_M50; pfam02163 997761013426 active site 997761013427 putative substrate binding region [chemical binding]; other site 997761013428 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 997761013429 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761013430 S-adenosylmethionine binding site [chemical binding]; other site 997761013431 YfhD-like protein; Region: YfhD; pfam14151 997761013432 chaperone protein DnaJ; Provisional; Region: PRK14280 997761013433 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 997761013434 HSP70 interaction site [polypeptide binding]; other site 997761013435 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 997761013436 substrate binding site [polypeptide binding]; other site 997761013437 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 997761013438 Zn binding sites [ion binding]; other site 997761013439 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 997761013440 dimer interface [polypeptide binding]; other site 997761013441 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 997761013442 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 997761013443 nucleotide binding site [chemical binding]; other site 997761013444 NEF interaction site [polypeptide binding]; other site 997761013445 SBD interface [polypeptide binding]; other site 997761013446 GrpE; Region: GrpE; pfam01025 997761013447 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 997761013448 dimer interface [polypeptide binding]; other site 997761013449 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 997761013450 chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309 997761013451 thermosome, various subunits, archaeal; Region: thermosome_arch; TIGR02339 997761013452 ATP/Mg binding site [chemical binding]; other site 997761013453 ring oligomerisation interface [polypeptide binding]; other site 997761013454 hinge regions; other site 997761013455 stacking interactions; other site 997761013456 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 997761013457 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 997761013458 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 997761013459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761013460 Coenzyme A binding pocket [chemical binding]; other site 997761013461 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 997761013462 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761013463 FeS/SAM binding site; other site 997761013464 HemN C-terminal domain; Region: HemN_C; pfam06969 997761013465 GTP-binding protein LepA; Provisional; Region: PRK05433 997761013466 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 997761013467 G1 box; other site 997761013468 putative GEF interaction site [polypeptide binding]; other site 997761013469 GTP/Mg2+ binding site [chemical binding]; other site 997761013470 Switch I region; other site 997761013471 G2 box; other site 997761013472 G3 box; other site 997761013473 Switch II region; other site 997761013474 G4 box; other site 997761013475 G5 box; other site 997761013476 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 997761013477 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 997761013478 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 997761013479 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 997761013480 stage II sporulation protein P; Region: spore_II_P; TIGR02867 997761013481 germination protease; Provisional; Region: PRK02858 997761013482 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 997761013483 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 997761013484 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 997761013485 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 997761013486 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761013487 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761013488 DNA binding residues [nucleotide binding] 997761013489 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 997761013490 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 997761013491 [2Fe-2S] cluster binding site [ion binding]; other site 997761013492 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 997761013493 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 997761013494 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 997761013495 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 997761013496 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 997761013497 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 997761013498 DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361 997761013499 Competence protein; Region: Competence; pfam03772 997761013500 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 997761013501 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 997761013502 catalytic motif [active] 997761013503 Zn binding site [ion binding]; other site 997761013504 late competence protein ComER; Validated; Region: PRK07680 997761013505 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 997761013506 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 997761013507 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 997761013508 HIGH motif; other site 997761013509 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 997761013510 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 997761013511 active site 997761013512 KMSKS motif; other site 997761013513 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 997761013514 tRNA binding surface [nucleotide binding]; other site 997761013515 Methyltransferase domain; Region: Methyltransf_31; pfam13847 997761013516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761013517 S-adenosylmethionine binding site [chemical binding]; other site 997761013518 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 997761013519 S1 domain; Region: S1_2; pfam13509 997761013520 S1 domain; Region: S1_2; pfam13509 997761013521 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 997761013522 putative DNA binding site [nucleotide binding]; other site 997761013523 putative Zn2+ binding site [ion binding]; other site 997761013524 Oligomerisation domain; Region: Oligomerisation; cl00519 997761013525 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 997761013526 Zn2+ binding site [ion binding]; other site 997761013527 Mg2+ binding site [ion binding]; other site 997761013528 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 997761013529 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 997761013530 active site 997761013531 (T/H)XGH motif; other site 997761013532 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 997761013533 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 997761013534 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 997761013535 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 997761013536 shikimate binding site; other site 997761013537 NAD(P) binding site [chemical binding]; other site 997761013538 GTPase YqeH; Provisional; Region: PRK13796 997761013539 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 997761013540 GTP/Mg2+ binding site [chemical binding]; other site 997761013541 G4 box; other site 997761013542 G5 box; other site 997761013543 G1 box; other site 997761013544 Switch I region; other site 997761013545 G2 box; other site 997761013546 G3 box; other site 997761013547 Switch II region; other site 997761013548 HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase 997761013549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761013550 active site 997761013551 motif I; other site 997761013552 motif II; other site 997761013553 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 997761013554 dimanganese center [ion binding]; other site 997761013555 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 997761013556 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 997761013557 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 997761013558 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 997761013559 MoxR-like ATPases [General function prediction only]; Region: COG0714 997761013560 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761013561 Walker A motif; other site 997761013562 ATP binding site [chemical binding]; other site 997761013563 Walker B motif; other site 997761013564 arginine finger; other site 997761013565 stage V sporulation protein AD; Provisional; Region: PRK12404 997761013566 Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451 997761013567 stage V sporulation protein AC; Region: spore_V_AC; TIGR02838 997761013568 Predicted membrane protein [Function unknown]; Region: COG2323 997761013569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 997761013570 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 997761013571 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 997761013572 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 997761013573 putative acyl-acceptor binding pocket; other site 997761013574 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 997761013575 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 997761013576 ligand binding site [chemical binding]; other site 997761013577 flexible hinge region; other site 997761013578 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 997761013579 putative switch regulator; other site 997761013580 non-specific DNA interactions [nucleotide binding]; other site 997761013581 DNA binding site [nucleotide binding] 997761013582 sequence specific DNA binding site [nucleotide binding]; other site 997761013583 putative cAMP binding site [chemical binding]; other site 997761013584 Response regulator receiver domain; Region: Response_reg; pfam00072 997761013585 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761013586 active site 997761013587 phosphorylation site [posttranslational modification] 997761013588 intermolecular recognition site; other site 997761013589 dimerization interface [polypeptide binding]; other site 997761013590 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 997761013591 Methyltransferase domain; Region: Methyltransf_31; pfam13847 997761013592 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761013593 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 997761013594 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761013595 Coenzyme A binding pocket [chemical binding]; other site 997761013596 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 997761013597 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761013598 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761013599 DNA binding site [nucleotide binding] 997761013600 domain linker motif; other site 997761013601 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 997761013602 dimerization interface [polypeptide binding]; other site 997761013603 ligand binding site [chemical binding]; other site 997761013604 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 997761013605 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761013606 NAD(P) binding site [chemical binding]; other site 997761013607 active site 997761013608 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 997761013609 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 997761013610 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 997761013611 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761013612 dimerization interface [polypeptide binding]; other site 997761013613 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761013614 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761013615 dimer interface [polypeptide binding]; other site 997761013616 putative CheW interface [polypeptide binding]; other site 997761013617 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761013618 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 997761013619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761013620 Walker A/P-loop; other site 997761013621 ATP binding site [chemical binding]; other site 997761013622 Q-loop/lid; other site 997761013623 ABC transporter signature motif; other site 997761013624 Walker B; other site 997761013625 D-loop; other site 997761013626 H-loop/switch region; other site 997761013627 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 997761013628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761013629 dimer interface [polypeptide binding]; other site 997761013630 conserved gate region; other site 997761013631 putative PBP binding loops; other site 997761013632 ABC-ATPase subunit interface; other site 997761013633 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 997761013634 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761013635 substrate binding pocket [chemical binding]; other site 997761013636 membrane-bound complex binding site; other site 997761013637 hinge residues; other site 997761013638 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761013639 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 997761013640 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 997761013641 Uncharacterized conserved protein [Function unknown]; Region: COG4278 997761013642 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 997761013643 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 997761013644 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 997761013645 active site 997761013646 catalytic site [active] 997761013647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761013648 dimerization interface [polypeptide binding]; other site 997761013649 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761013650 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761013651 dimer interface [polypeptide binding]; other site 997761013652 putative CheW interface [polypeptide binding]; other site 997761013653 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 997761013654 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 997761013655 ligand binding site [chemical binding]; other site 997761013656 Response regulator receiver domain; Region: Response_reg; pfam00072 997761013657 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761013658 active site 997761013659 phosphorylation site [posttranslational modification] 997761013660 intermolecular recognition site; other site 997761013661 dimerization interface [polypeptide binding]; other site 997761013662 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761013663 dimer interface [polypeptide binding]; other site 997761013664 phosphorylation site [posttranslational modification] 997761013665 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761013666 ATP binding site [chemical binding]; other site 997761013667 Mg2+ binding site [ion binding]; other site 997761013668 G-X-G motif; other site 997761013669 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 997761013670 CheB methylesterase; Region: CheB_methylest; pfam01339 997761013671 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 997761013672 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 997761013673 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 997761013674 Nitrate and nitrite sensing; Region: NIT; pfam08376 997761013675 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 997761013676 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761013677 dimerization interface [polypeptide binding]; other site 997761013678 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 997761013679 GAF domain; Region: GAF; pfam01590 997761013680 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761013681 dimer interface [polypeptide binding]; other site 997761013682 phosphorylation site [posttranslational modification] 997761013683 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761013684 ATP binding site [chemical binding]; other site 997761013685 Mg2+ binding site [ion binding]; other site 997761013686 G-X-G motif; other site 997761013687 Response regulator receiver domain; Region: Response_reg; pfam00072 997761013688 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761013689 active site 997761013690 phosphorylation site [posttranslational modification] 997761013691 intermolecular recognition site; other site 997761013692 dimerization interface [polypeptide binding]; other site 997761013693 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 997761013694 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761013695 active site 997761013696 phosphorylation site [posttranslational modification] 997761013697 intermolecular recognition site; other site 997761013698 dimerization interface [polypeptide binding]; other site 997761013699 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 997761013700 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761013701 active site 997761013702 phosphorylation site [posttranslational modification] 997761013703 intermolecular recognition site; other site 997761013704 dimerization interface [polypeptide binding]; other site 997761013705 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 997761013706 active site 997761013707 intersubunit interactions; other site 997761013708 catalytic residue [active] 997761013709 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 997761013710 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 997761013711 TPP-binding site [chemical binding]; other site 997761013712 dimer interface [polypeptide binding]; other site 997761013713 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 997761013714 PYR/PP interface [polypeptide binding]; other site 997761013715 dimer interface [polypeptide binding]; other site 997761013716 TPP binding site [chemical binding]; other site 997761013717 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 997761013718 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761013719 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761013720 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761013721 dimerization interface [polypeptide binding]; other site 997761013722 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761013723 dimerization interface [polypeptide binding]; other site 997761013724 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761013725 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761013726 dimer interface [polypeptide binding]; other site 997761013727 putative CheW interface [polypeptide binding]; other site 997761013728 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 997761013729 CoenzymeA binding site [chemical binding]; other site 997761013730 subunit interaction site [polypeptide binding]; other site 997761013731 PHB binding site; other site 997761013732 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710 997761013733 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 997761013734 acyl-activating enzyme (AAE) consensus motif; other site 997761013735 putative AMP binding site [chemical binding]; other site 997761013736 putative active site [active] 997761013737 putative CoA binding site [chemical binding]; other site 997761013738 acetyl-CoA acetyltransferase; Provisional; Region: PRK07661 997761013739 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 997761013740 dimer interface [polypeptide binding]; other site 997761013741 active site 997761013742 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 997761013743 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 997761013744 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 997761013745 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 997761013746 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 997761013747 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 997761013748 substrate binding site [chemical binding]; other site 997761013749 oxyanion hole (OAH) forming residues; other site 997761013750 trimer interface [polypeptide binding]; other site 997761013751 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761013752 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761013753 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 997761013754 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 997761013755 Ligand binding site [chemical binding]; other site 997761013756 Electron transfer flavoprotein domain; Region: ETF; pfam01012 997761013757 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 997761013758 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 997761013759 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761013760 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761013761 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761013762 Dienelactone hydrolase family; Region: DLH; pfam01738 997761013763 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 997761013764 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 997761013765 regulatory protein interface [polypeptide binding]; other site 997761013766 active site 997761013767 regulatory phosphorylation site [posttranslational modification]; other site 997761013768 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333 997761013769 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 997761013770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 997761013771 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 997761013772 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761013773 putative active site [active] 997761013774 heme pocket [chemical binding]; other site 997761013775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761013776 ATP binding site [chemical binding]; other site 997761013777 Mg2+ binding site [ion binding]; other site 997761013778 G-X-G motif; other site 997761013779 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 997761013780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761013781 active site 997761013782 phosphorylation site [posttranslational modification] 997761013783 intermolecular recognition site; other site 997761013784 dimerization interface [polypeptide binding]; other site 997761013785 Transcriptional regulator; Region: CitT; pfam12431 997761013786 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 997761013787 LysE type translocator; Region: LysE; pfam01810 997761013788 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 997761013789 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 997761013790 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 997761013791 active site 997761013792 non-prolyl cis peptide bond; other site 997761013793 Predicted transcriptional regulator [Transcription]; Region: COG4189 997761013794 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761013795 dimerization interface [polypeptide binding]; other site 997761013796 putative DNA binding site [nucleotide binding]; other site 997761013797 putative Zn2+ binding site [ion binding]; other site 997761013798 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 997761013799 active site 997761013800 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761013801 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761013802 dimer interface [polypeptide binding]; other site 997761013803 conserved gate region; other site 997761013804 putative PBP binding loops; other site 997761013805 ABC-ATPase subunit interface; other site 997761013806 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761013807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761013808 dimer interface [polypeptide binding]; other site 997761013809 ABC-ATPase subunit interface; other site 997761013810 putative PBP binding loops; other site 997761013811 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 997761013812 active site 997761013813 Predicted transcriptional regulator [Transcription]; Region: COG4189 997761013814 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761013815 dimerization interface [polypeptide binding]; other site 997761013816 putative DNA binding site [nucleotide binding]; other site 997761013817 putative Zn2+ binding site [ion binding]; other site 997761013818 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 997761013819 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 997761013820 Metal-binding active site; metal-binding site 997761013821 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 997761013822 alpha-galactosidase; Region: PLN02808; cl17638 997761013823 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 997761013824 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 997761013825 intersubunit interface [polypeptide binding]; other site 997761013826 active site 997761013827 zinc binding site [ion binding]; other site 997761013828 Na+ binding site [ion binding]; other site 997761013829 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 997761013830 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 997761013831 tetrameric interface [polypeptide binding]; other site 997761013832 NAD binding site [chemical binding]; other site 997761013833 catalytic residues [active] 997761013834 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 997761013835 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761013836 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761013837 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 997761013838 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761013839 dimer interface [polypeptide binding]; other site 997761013840 putative PBP binding regions; other site 997761013841 ABC-ATPase subunit interface; other site 997761013842 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 997761013843 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761013844 ABC-ATPase subunit interface; other site 997761013845 dimer interface [polypeptide binding]; other site 997761013846 putative PBP binding regions; other site 997761013847 Predicted ATPase [General function prediction only]; Region: COG3910 997761013848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761013849 Walker A/P-loop; other site 997761013850 ATP binding site [chemical binding]; other site 997761013851 Q-loop/lid; other site 997761013852 ABC transporter signature motif; other site 997761013853 Walker B; other site 997761013854 D-loop; other site 997761013855 H-loop/switch region; other site 997761013856 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761013857 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 997761013858 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 997761013859 inhibitor binding site; inhibition site 997761013860 active site 997761013861 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761013862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761013863 dimer interface [polypeptide binding]; other site 997761013864 conserved gate region; other site 997761013865 putative PBP binding loops; other site 997761013866 ABC-ATPase subunit interface; other site 997761013867 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761013868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761013869 dimer interface [polypeptide binding]; other site 997761013870 conserved gate region; other site 997761013871 ABC-ATPase subunit interface; other site 997761013872 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761013873 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761013874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761013875 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 997761013876 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 997761013877 active site 997761013878 Pectate lyase; Region: Pec_lyase_C; cl01593 997761013879 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761013880 Interdomain contacts; other site 997761013881 Cytokine receptor motif; other site 997761013882 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761013883 Interdomain contacts; other site 997761013884 Cytokine receptor motif; other site 997761013885 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761013886 Interdomain contacts; other site 997761013887 Cytokine receptor motif; other site 997761013888 putative pectinesterase; Region: PLN02432; cl01911 997761013889 Pectinesterase; Region: Pectinesterase; pfam01095 997761013890 conserved hypothetical protein; Region: lin0512_fam; TIGR02058 997761013891 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 997761013892 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 997761013893 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 997761013894 putative metal binding site; other site 997761013895 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 997761013896 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 997761013897 binding surface 997761013898 TPR motif; other site 997761013899 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 997761013900 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 997761013901 active site 997761013902 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 997761013903 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761013904 putative homodimer interface [polypeptide binding]; other site 997761013905 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 997761013906 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 997761013907 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950 997761013908 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761013909 putative homodimer interface [polypeptide binding]; other site 997761013910 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 997761013911 metal binding site [ion binding]; metal-binding site 997761013912 active site 997761013913 S-formylglutathione hydrolase; Region: PLN02442 997761013914 Putative esterase; Region: Esterase; pfam00756 997761013915 S-layer homology domain; Region: SLH; pfam00395 997761013916 S-layer homology domain; Region: SLH; pfam00395 997761013917 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 997761013918 active site 997761013919 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 997761013920 Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897 997761013921 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761013922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761013923 homodimer interface [polypeptide binding]; other site 997761013924 catalytic residue [active] 997761013925 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 997761013926 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 997761013927 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761013928 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761013929 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761013930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761013931 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 997761013932 catalytic core [active] 997761013933 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761013934 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761013935 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 997761013936 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 997761013937 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 997761013938 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 997761013939 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761013940 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761013941 DNA binding site [nucleotide binding] 997761013942 domain linker motif; other site 997761013943 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 997761013944 dimerization interface [polypeptide binding]; other site 997761013945 ligand binding site [chemical binding]; other site 997761013946 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 997761013947 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761013948 Interdomain contacts; other site 997761013949 Cytokine receptor motif; other site 997761013950 Cellulose binding domain; Region: CBM_3; pfam00942 997761013951 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 997761013952 dimer interface [polypeptide binding]; other site 997761013953 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761013954 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 997761013955 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761013956 Coenzyme A binding pocket [chemical binding]; other site 997761013957 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 997761013958 HEAT repeats; Region: HEAT_2; pfam13646 997761013959 Uncharacterized protein domain similar to Clostridium thermocellum 2751; Region: Cthe_2751_like; cd11743 997761013960 dimer interface [polypeptide binding]; other site 997761013961 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 997761013962 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 997761013963 active site 997761013964 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 997761013965 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 997761013966 Coenzyme A binding pocket [chemical binding]; other site 997761013967 Putative transcription activator [Transcription]; Region: TenA; COG0819 997761013968 acetylornithine deacetylase; Validated; Region: PRK08596 997761013969 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 997761013970 metal binding site [ion binding]; metal-binding site 997761013971 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 997761013972 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 997761013973 Walker A/P-loop; other site 997761013974 ATP binding site [chemical binding]; other site 997761013975 Q-loop/lid; other site 997761013976 ABC transporter signature motif; other site 997761013977 Walker B; other site 997761013978 D-loop; other site 997761013979 H-loop/switch region; other site 997761013980 BioY family; Region: BioY; pfam02632 997761013981 Glycosyl hydrolase family 43; Region: GH43_5; cd08984 997761013982 active site 997761013983 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 997761013984 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 997761013985 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 997761013986 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 997761013987 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 997761013988 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 997761013989 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 997761013990 Cysteine-rich domain; Region: CCG; pfam02754 997761013991 Cysteine-rich domain; Region: CCG; pfam02754 997761013992 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 997761013993 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 997761013994 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 997761013995 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 997761013996 N- and C-terminal domain interface [polypeptide binding]; other site 997761013997 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 997761013998 active site 997761013999 putative catalytic site [active] 997761014000 metal binding site [ion binding]; metal-binding site 997761014001 ATP binding site [chemical binding]; other site 997761014002 carbohydrate binding site [chemical binding]; other site 997761014003 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 997761014004 short chain dehydrogenase; Validated; Region: PRK08324 997761014005 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 997761014006 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 997761014007 putative NAD(P) binding site [chemical binding]; other site 997761014008 active site 997761014009 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 997761014010 intersubunit interface [polypeptide binding]; other site 997761014011 active site 997761014012 Zn2+ binding site [ion binding]; other site 997761014013 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 997761014014 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 997761014015 active site 997761014016 intersubunit interface [polypeptide binding]; other site 997761014017 Zn2+ binding site [ion binding]; other site 997761014018 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 997761014019 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761014020 MarR family; Region: MarR_2; pfam12802 997761014021 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761014022 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761014023 putative substrate translocation pore; other site 997761014024 NADH(P)-binding; Region: NAD_binding_10; pfam13460 997761014025 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761014026 NAD(P) binding site [chemical binding]; other site 997761014027 active site 997761014028 Response regulator receiver domain; Region: Response_reg; pfam00072 997761014029 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761014030 active site 997761014031 phosphorylation site [posttranslational modification] 997761014032 intermolecular recognition site; other site 997761014033 dimerization interface [polypeptide binding]; other site 997761014034 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761014035 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761014036 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 997761014037 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 997761014038 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 997761014039 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761014040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761014041 homodimer interface [polypeptide binding]; other site 997761014042 catalytic residue [active] 997761014043 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 997761014044 active site 997761014045 catalytic triad [active] 997761014046 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761014047 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761014048 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761014049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761014050 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 997761014051 Predicted membrane protein [Function unknown]; Region: COG4709 997761014052 Regulatory protein YrvL; Region: YrvL; pfam14184 997761014053 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 997761014054 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 997761014055 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 997761014056 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 997761014057 dimerization interface [polypeptide binding]; other site 997761014058 NAD binding site [chemical binding]; other site 997761014059 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 997761014060 ligand binding site [chemical binding]; other site 997761014061 catalytic site [active] 997761014062 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 997761014063 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761014064 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 997761014065 Walker A/P-loop; other site 997761014066 ATP binding site [chemical binding]; other site 997761014067 Q-loop/lid; other site 997761014068 ABC transporter signature motif; other site 997761014069 Walker B; other site 997761014070 D-loop; other site 997761014071 H-loop/switch region; other site 997761014072 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761014073 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761014074 metal binding site [ion binding]; metal-binding site 997761014075 active site 997761014076 I-site; other site 997761014077 Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990 997761014078 substrate binding site [chemical binding]; other site 997761014079 active site 997761014080 Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270 997761014081 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 997761014082 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 997761014083 S-layer homology domain; Region: SLH; pfam00395 997761014084 S-layer homology domain; Region: SLH; pfam00395 997761014085 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 997761014086 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 997761014087 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 997761014088 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 997761014089 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 997761014090 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 997761014091 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 997761014092 active site 997761014093 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 997761014094 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761014095 substrate binding pocket [chemical binding]; other site 997761014096 membrane-bound complex binding site; other site 997761014097 hinge residues; other site 997761014098 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 997761014099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761014100 dimer interface [polypeptide binding]; other site 997761014101 conserved gate region; other site 997761014102 putative PBP binding loops; other site 997761014103 ABC-ATPase subunit interface; other site 997761014104 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 997761014105 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 997761014106 substrate binding pocket [chemical binding]; other site 997761014107 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 997761014108 Peptidase C26; Region: Peptidase_C26; pfam07722 997761014109 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 997761014110 catalytic triad [active] 997761014111 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 997761014112 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 997761014113 nucleotide binding site [chemical binding]; other site 997761014114 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761014115 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 997761014116 NlpC/P60 family; Region: NLPC_P60; pfam00877 997761014117 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 997761014118 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 997761014119 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 997761014120 putative pectinesterase; Region: PLN02432; cl01911 997761014121 YhfH-like protein; Region: YhfH; pfam14149 997761014122 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761014123 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761014124 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 997761014125 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 997761014126 metal-binding site [ion binding] 997761014127 Arginase family; Region: Arginase; cd09989 997761014128 active site 997761014129 Mn binding site [ion binding]; other site 997761014130 oligomer interface [polypeptide binding]; other site 997761014131 Arginase family; Region: Arginase; cd09989 997761014132 active site 997761014133 Mn binding site [ion binding]; other site 997761014134 oligomer interface [polypeptide binding]; other site 997761014135 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761014136 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761014137 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761014138 dimerization interface [polypeptide binding]; other site 997761014139 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 997761014140 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 997761014141 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 997761014142 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 997761014143 S-methylmethionine transporter; Provisional; Region: PRK11387 997761014144 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 997761014145 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 997761014146 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 997761014147 NAD(P) binding site [chemical binding]; other site 997761014148 ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073 997761014149 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 997761014150 inhibitor-cofactor binding pocket; inhibition site 997761014151 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761014152 catalytic residue [active] 997761014153 hypothetical protein; Provisional; Region: PRK09739 997761014154 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 997761014155 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761014156 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761014157 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761014158 dimerization interface [polypeptide binding]; other site 997761014159 Histidine kinase; Region: His_kinase; pfam06580 997761014160 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761014161 ATP binding site [chemical binding]; other site 997761014162 G-X-G motif; other site 997761014163 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761014164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761014165 dimer interface [polypeptide binding]; other site 997761014166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761014167 ABC-ATPase subunit interface; other site 997761014168 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761014169 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 997761014170 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761014171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761014172 dimer interface [polypeptide binding]; other site 997761014173 conserved gate region; other site 997761014174 putative PBP binding loops; other site 997761014175 ABC-ATPase subunit interface; other site 997761014176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761014177 dimer interface [polypeptide binding]; other site 997761014178 conserved gate region; other site 997761014179 putative PBP binding loops; other site 997761014180 ABC-ATPase subunit interface; other site 997761014181 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761014182 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761014183 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761014184 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761014185 dimerization interface [polypeptide binding]; other site 997761014186 Histidine kinase; Region: His_kinase; pfam06580 997761014187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761014188 ATP binding site [chemical binding]; other site 997761014189 Mg2+ binding site [ion binding]; other site 997761014190 G-X-G motif; other site 997761014191 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 997761014192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761014193 active site 997761014194 phosphorylation site [posttranslational modification] 997761014195 intermolecular recognition site; other site 997761014196 dimerization interface [polypeptide binding]; other site 997761014197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761014198 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 997761014199 putative FMN binding site [chemical binding]; other site 997761014200 NADPH bind site [chemical binding]; other site 997761014201 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 997761014202 putative FMN binding site [chemical binding]; other site 997761014203 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 997761014204 YcaO-like family; Region: YcaO; pfam02624 997761014205 thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604 997761014206 putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693 997761014207 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 997761014208 DinB superfamily; Region: DinB_2; pfam12867 997761014209 Protein of unknown function (DUF664); Region: DUF664; pfam04978 997761014210 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 997761014211 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 997761014212 active site 1 [active] 997761014213 dimer interface [polypeptide binding]; other site 997761014214 hexamer interface [polypeptide binding]; other site 997761014215 active site 2 [active] 997761014216 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761014217 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761014218 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761014219 dimerization interface [polypeptide binding]; other site 997761014220 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761014221 dimerization interface [polypeptide binding]; other site 997761014222 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761014223 Histidine kinase; Region: His_kinase; pfam06580 997761014224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761014225 ATP binding site [chemical binding]; other site 997761014226 Mg2+ binding site [ion binding]; other site 997761014227 G-X-G motif; other site 997761014228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761014229 Response regulator receiver domain; Region: Response_reg; pfam00072 997761014230 active site 997761014231 phosphorylation site [posttranslational modification] 997761014232 intermolecular recognition site; other site 997761014233 dimerization interface [polypeptide binding]; other site 997761014234 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761014235 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761014236 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761014237 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761014238 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761014239 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761014240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761014241 dimer interface [polypeptide binding]; other site 997761014242 conserved gate region; other site 997761014243 putative PBP binding loops; other site 997761014244 ABC-ATPase subunit interface; other site 997761014245 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761014246 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 997761014247 Cupin; Region: Cupin_1; smart00835 997761014248 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761014249 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761014250 DNA binding site [nucleotide binding] 997761014251 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 997761014252 Domain of unknown function (DUF336); Region: DUF336; cl01249 997761014253 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 997761014254 active site 997761014255 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 997761014256 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761014257 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761014258 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 997761014259 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761014260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761014261 dimer interface [polypeptide binding]; other site 997761014262 conserved gate region; other site 997761014263 ABC-ATPase subunit interface; other site 997761014264 Cache domain; Region: Cache_1; pfam02743 997761014265 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761014266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761014267 metal binding site [ion binding]; metal-binding site 997761014268 active site 997761014269 I-site; other site 997761014270 short chain dehydrogenase; Validated; Region: PRK06182 997761014271 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 997761014272 NADP binding site [chemical binding]; other site 997761014273 active site 997761014274 steroid binding site; other site 997761014275 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761014276 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761014277 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 997761014278 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 997761014279 putative ligand binding site [chemical binding]; other site 997761014280 Cache domain; Region: Cache_1; pfam02743 997761014281 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761014282 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761014283 dimerization interface [polypeptide binding]; other site 997761014284 Histidine kinase; Region: His_kinase; pfam06580 997761014285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761014286 ATP binding site [chemical binding]; other site 997761014287 Mg2+ binding site [ion binding]; other site 997761014288 G-X-G motif; other site 997761014289 Response regulator receiver domain; Region: Response_reg; pfam00072 997761014290 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761014291 active site 997761014292 phosphorylation site [posttranslational modification] 997761014293 intermolecular recognition site; other site 997761014294 dimerization interface [polypeptide binding]; other site 997761014295 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761014296 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761014297 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761014298 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 997761014299 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 997761014300 putative ligand binding site [chemical binding]; other site 997761014301 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761014302 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 997761014303 TM-ABC transporter signature motif; other site 997761014304 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 997761014305 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 997761014306 Walker A/P-loop; other site 997761014307 ATP binding site [chemical binding]; other site 997761014308 Q-loop/lid; other site 997761014309 ABC transporter signature motif; other site 997761014310 Walker B; other site 997761014311 D-loop; other site 997761014312 H-loop/switch region; other site 997761014313 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 997761014314 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 997761014315 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761014316 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761014317 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761014318 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 997761014319 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 997761014320 metal binding site [ion binding]; metal-binding site 997761014321 substrate binding pocket [chemical binding]; other site 997761014322 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 997761014323 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 997761014324 NAD(P) binding site [chemical binding]; other site 997761014325 catalytic residues [active] 997761014326 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761014327 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761014328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761014329 dimer interface [polypeptide binding]; other site 997761014330 conserved gate region; other site 997761014331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 997761014332 ABC-ATPase subunit interface; other site 997761014333 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761014334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761014335 dimer interface [polypeptide binding]; other site 997761014336 conserved gate region; other site 997761014337 ABC-ATPase subunit interface; other site 997761014338 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 997761014339 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 997761014340 Walker A/P-loop; other site 997761014341 ATP binding site [chemical binding]; other site 997761014342 Q-loop/lid; other site 997761014343 ABC transporter signature motif; other site 997761014344 Walker B; other site 997761014345 D-loop; other site 997761014346 H-loop/switch region; other site 997761014347 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 997761014348 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 997761014349 Walker A/P-loop; other site 997761014350 ATP binding site [chemical binding]; other site 997761014351 Q-loop/lid; other site 997761014352 ABC transporter signature motif; other site 997761014353 Walker B; other site 997761014354 D-loop; other site 997761014355 H-loop/switch region; other site 997761014356 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 997761014357 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 997761014358 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 997761014359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761014360 dimer interface [polypeptide binding]; other site 997761014361 conserved gate region; other site 997761014362 putative PBP binding loops; other site 997761014363 ABC-ATPase subunit interface; other site 997761014364 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 997761014365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761014366 dimer interface [polypeptide binding]; other site 997761014367 conserved gate region; other site 997761014368 putative PBP binding loops; other site 997761014369 ABC-ATPase subunit interface; other site 997761014370 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 997761014371 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 997761014372 substrate binding site [chemical binding]; other site 997761014373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761014374 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761014375 putative substrate translocation pore; other site 997761014376 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761014377 Helix-turn-helix domain; Region: HTH_18; pfam12833 997761014378 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761014379 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 997761014380 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 997761014381 active site 997761014382 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 997761014383 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 997761014384 S-layer homology domain; Region: SLH; pfam00395 997761014385 S-layer homology domain; Region: SLH; pfam00395 997761014386 S-layer homology domain; Region: SLH; pfam00395 997761014387 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 997761014388 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 997761014389 FtsX-like permease family; Region: FtsX; pfam02687 997761014390 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 997761014391 FtsX-like permease family; Region: FtsX; pfam02687 997761014392 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 997761014393 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 997761014394 Walker A/P-loop; other site 997761014395 ATP binding site [chemical binding]; other site 997761014396 Q-loop/lid; other site 997761014397 ABC transporter signature motif; other site 997761014398 Walker B; other site 997761014399 D-loop; other site 997761014400 H-loop/switch region; other site 997761014401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 997761014402 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 997761014403 sporulation sigma factor SigK; Reviewed; Region: PRK05803 997761014404 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761014405 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761014406 DNA binding residues [nucleotide binding] 997761014407 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761014408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761014409 dimer interface [polypeptide binding]; other site 997761014410 conserved gate region; other site 997761014411 ABC-ATPase subunit interface; other site 997761014412 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761014413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761014414 dimer interface [polypeptide binding]; other site 997761014415 conserved gate region; other site 997761014416 putative PBP binding loops; other site 997761014417 ABC-ATPase subunit interface; other site 997761014418 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761014419 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 997761014420 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761014421 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761014422 Uncharacterized conserved protein [Function unknown]; Region: COG1284 997761014423 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 997761014424 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 997761014425 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 997761014426 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 997761014427 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 997761014428 putative active site [active] 997761014429 putative metal binding site [ion binding]; other site 997761014430 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 997761014431 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 997761014432 generic binding surface I; other site 997761014433 generic binding surface II; other site 997761014434 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 997761014435 SCP-2 sterol transfer family; Region: SCP2; pfam02036 997761014436 C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733 997761014437 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 997761014438 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 997761014439 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 997761014440 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 997761014441 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 997761014442 HlyD family secretion protein; Region: HlyD_3; pfam13437 997761014443 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 997761014444 Melibiase; Region: Melibiase; pfam02065 997761014445 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761014446 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761014447 metal binding site [ion binding]; metal-binding site 997761014448 active site 997761014449 I-site; other site 997761014450 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 997761014451 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 997761014452 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 997761014453 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 997761014454 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 997761014455 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 997761014456 E3 interaction surface; other site 997761014457 lipoyl attachment site [posttranslational modification]; other site 997761014458 e3 binding domain; Region: E3_binding; pfam02817 997761014459 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 997761014460 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 997761014461 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 997761014462 alpha subunit interface [polypeptide binding]; other site 997761014463 TPP binding site [chemical binding]; other site 997761014464 heterodimer interface [polypeptide binding]; other site 997761014465 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 997761014466 Putative esterase; Region: Esterase; pfam00756 997761014467 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 997761014468 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 997761014469 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 997761014470 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 997761014471 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 997761014472 active site 997761014473 metal binding site [ion binding]; metal-binding site 997761014474 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 997761014475 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761014476 Response regulator receiver domain; Region: Response_reg; pfam00072 997761014477 active site 997761014478 phosphorylation site [posttranslational modification] 997761014479 intermolecular recognition site; other site 997761014480 dimerization interface [polypeptide binding]; other site 997761014481 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 997761014482 GAF domain; Region: GAF_3; pfam13492 997761014483 Predicted membrane protein [Function unknown]; Region: COG4267 997761014484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761014485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761014486 dimer interface [polypeptide binding]; other site 997761014487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761014488 ATP binding site [chemical binding]; other site 997761014489 Mg2+ binding site [ion binding]; other site 997761014490 G-X-G motif; other site 997761014491 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761014492 dimerization interface [polypeptide binding]; other site 997761014493 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761014494 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761014495 dimer interface [polypeptide binding]; other site 997761014496 putative CheW interface [polypeptide binding]; other site 997761014497 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 997761014498 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 997761014499 Peptidase family U32; Region: Peptidase_U32; pfam01136 997761014500 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 997761014501 Peptidase family U32; Region: Peptidase_U32; pfam01136 997761014502 hypothetical protein; Provisional; Region: PRK13678 997761014503 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 997761014504 hypothetical protein; Provisional; Region: PRK05473 997761014505 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 997761014506 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 997761014507 motif 1; other site 997761014508 active site 997761014509 motif 2; other site 997761014510 motif 3; other site 997761014511 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 997761014512 DHHA1 domain; Region: DHHA1; pfam02272 997761014513 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 997761014514 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761014515 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761014516 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761014517 Spore germination protein; Region: Spore_permease; cl17796 997761014518 PRC-barrel domain containing protein [General function prediction only]; Region: COG3881 997761014519 PRC-barrel domain; Region: PRC; pfam05239 997761014520 PRC-barrel domain; Region: PRC; pfam05239 997761014521 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 997761014522 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 997761014523 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 997761014524 catalytic residue [active] 997761014525 Predicted transcriptional regulator [Transcription]; Region: COG1959 997761014526 Transcriptional regulator; Region: Rrf2; pfam02082 997761014527 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 997761014528 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 997761014529 recombination factor protein RarA; Reviewed; Region: PRK13342 997761014530 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761014531 Walker A motif; other site 997761014532 ATP binding site [chemical binding]; other site 997761014533 Walker B motif; other site 997761014534 arginine finger; other site 997761014535 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 997761014536 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 997761014537 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 997761014538 putative ATP binding site [chemical binding]; other site 997761014539 putative substrate interface [chemical binding]; other site 997761014540 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 997761014541 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 997761014542 dimer interface [polypeptide binding]; other site 997761014543 anticodon binding site; other site 997761014544 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 997761014545 homodimer interface [polypeptide binding]; other site 997761014546 motif 1; other site 997761014547 active site 997761014548 motif 2; other site 997761014549 GAD domain; Region: GAD; pfam02938 997761014550 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 997761014551 active site 997761014552 motif 3; other site 997761014553 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 997761014554 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 997761014555 putative active site [active] 997761014556 dimerization interface [polypeptide binding]; other site 997761014557 putative tRNAtyr binding site [nucleotide binding]; other site 997761014558 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 997761014559 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 997761014560 Zn2+ binding site [ion binding]; other site 997761014561 Mg2+ binding site [ion binding]; other site 997761014562 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 997761014563 synthetase active site [active] 997761014564 NTP binding site [chemical binding]; other site 997761014565 metal binding site [ion binding]; metal-binding site 997761014566 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 997761014567 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 997761014568 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 997761014569 active site 997761014570 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 997761014571 DHH family; Region: DHH; pfam01368 997761014572 DHHA1 domain; Region: DHHA1; pfam02272 997761014573 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 997761014574 Cation efflux family; Region: Cation_efflux; cl00316 997761014575 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 997761014576 Protein export membrane protein; Region: SecD_SecF; pfam02355 997761014577 protein-export membrane protein SecD; Region: secD; TIGR01129 997761014578 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 997761014579 Predicted membrane protein [Function unknown]; Region: COG2323 997761014580 Preprotein translocase subunit; Region: YajC; pfam02699 997761014581 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 997761014582 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 997761014583 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 997761014584 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 997761014585 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 997761014586 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761014587 Walker A motif; other site 997761014588 ATP binding site [chemical binding]; other site 997761014589 Walker B motif; other site 997761014590 arginine finger; other site 997761014591 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 997761014592 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 997761014593 RuvA N terminal domain; Region: RuvA_N; pfam01330 997761014594 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 997761014595 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 997761014596 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 997761014597 active site 997761014598 BofC C-terminal domain; Region: BofC_C; pfam08955 997761014599 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 997761014600 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 997761014601 Catalytic site [active] 997761014602 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 997761014603 MgtC family; Region: MgtC; pfam02308 997761014604 prephenate dehydratase; Provisional; Region: PRK11898 997761014605 Prephenate dehydratase; Region: PDT; pfam00800 997761014606 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 997761014607 putative L-Phe binding site [chemical binding]; other site 997761014608 homoserine kinase; Provisional; Region: PRK01212 997761014609 homoserine dehydrogenase; Provisional; Region: PRK06349 997761014610 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 997761014611 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 997761014612 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 997761014613 hypothetical protein; Provisional; Region: PRK04435 997761014614 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 997761014615 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 997761014616 nudix motif; other site 997761014617 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 997761014618 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761014619 Walker A/P-loop; other site 997761014620 ATP binding site [chemical binding]; other site 997761014621 Q-loop/lid; other site 997761014622 ABC transporter signature motif; other site 997761014623 Walker B; other site 997761014624 D-loop; other site 997761014625 H-loop/switch region; other site 997761014626 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 997761014627 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 997761014628 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 997761014629 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 997761014630 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 997761014631 [4Fe-4S] binding site [ion binding]; other site 997761014632 molybdopterin cofactor binding site; other site 997761014633 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 997761014634 molybdopterin cofactor binding site; other site 997761014635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761014636 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 997761014637 putative substrate translocation pore; other site 997761014638 GTPase CgtA; Reviewed; Region: obgE; PRK12297 997761014639 GTP1/OBG; Region: GTP1_OBG; pfam01018 997761014640 Obg GTPase; Region: Obg; cd01898 997761014641 G1 box; other site 997761014642 GTP/Mg2+ binding site [chemical binding]; other site 997761014643 Switch I region; other site 997761014644 G2 box; other site 997761014645 G3 box; other site 997761014646 Switch II region; other site 997761014647 G4 box; other site 997761014648 G5 box; other site 997761014649 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 997761014650 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 997761014651 Protein of unknown function (DUF464); Region: DUF464; pfam04327 997761014652 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 997761014653 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 997761014654 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 997761014655 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 997761014656 homodimer interface [polypeptide binding]; other site 997761014657 oligonucleotide binding site [chemical binding]; other site 997761014658 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 997761014659 Peptidase family M50; Region: Peptidase_M50; pfam02163 997761014660 active site 997761014661 putative substrate binding region [chemical binding]; other site 997761014662 Peptidase family M23; Region: Peptidase_M23; pfam01551 997761014663 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 997761014664 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 997761014665 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 997761014666 Switch I; other site 997761014667 Switch II; other site 997761014668 septum formation inhibitor; Reviewed; Region: minC; PRK00513 997761014669 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 997761014670 rod shape-determining protein MreD; Region: MreD; cl01087 997761014671 rod shape-determining protein MreC; Provisional; Region: PRK13922 997761014672 rod shape-determining protein MreC; Region: MreC; pfam04085 997761014673 rod shape-determining protein MreB; Provisional; Region: PRK13927 997761014674 MreB and similar proteins; Region: MreB_like; cd10225 997761014675 nucleotide binding site [chemical binding]; other site 997761014676 Mg binding site [ion binding]; other site 997761014677 putative protofilament interaction site [polypeptide binding]; other site 997761014678 RodZ interaction site [polypeptide binding]; other site 997761014679 hypothetical protein; Reviewed; Region: PRK00024 997761014680 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 997761014681 MPN+ (JAMM) motif; other site 997761014682 Zinc-binding site [ion binding]; other site 997761014683 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 997761014684 active site 997761014685 dimer interface [polypeptide binding]; other site 997761014686 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 997761014687 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 997761014688 active site 997761014689 metal binding site [ion binding]; metal-binding site 997761014690 S-layer homology domain; Region: SLH; pfam00395 997761014691 S-layer homology domain; Region: SLH; pfam00395 997761014692 S-layer homology domain; Region: SLH; pfam00395 997761014693 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 997761014694 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 997761014695 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 997761014696 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 997761014697 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 997761014698 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 997761014699 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 997761014700 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 997761014701 active site 997761014702 HIGH motif; other site 997761014703 nucleotide binding site [chemical binding]; other site 997761014704 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 997761014705 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 997761014706 active site 997761014707 KMSKS motif; other site 997761014708 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 997761014709 tRNA binding surface [nucleotide binding]; other site 997761014710 anticodon binding site; other site 997761014711 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 997761014712 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 997761014713 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 997761014714 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 997761014715 active site 997761014716 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 997761014717 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 997761014718 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 997761014719 inhibitor-cofactor binding pocket; inhibition site 997761014720 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761014721 catalytic residue [active] 997761014722 ferrochelatase; Provisional; Region: PRK12435 997761014723 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 997761014724 C-terminal domain interface [polypeptide binding]; other site 997761014725 active site 997761014726 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 997761014727 active site 997761014728 N-terminal domain interface [polypeptide binding]; other site 997761014729 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 997761014730 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 997761014731 substrate binding site [chemical binding]; other site 997761014732 active site 997761014733 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 997761014734 dimer interface [polypeptide binding]; other site 997761014735 active site 997761014736 Schiff base residues; other site 997761014737 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 997761014738 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 997761014739 domain interfaces; other site 997761014740 active site 997761014741 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 997761014742 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 997761014743 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 997761014744 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 997761014745 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 997761014746 tRNA; other site 997761014747 putative tRNA binding site [nucleotide binding]; other site 997761014748 putative NADP binding site [chemical binding]; other site 997761014749 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 997761014750 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 997761014751 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 997761014752 G1 box; other site 997761014753 GTP/Mg2+ binding site [chemical binding]; other site 997761014754 Switch I region; other site 997761014755 G2 box; other site 997761014756 G3 box; other site 997761014757 Switch II region; other site 997761014758 G4 box; other site 997761014759 G5 box; other site 997761014760 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 997761014761 Found in ATP-dependent protease La (LON); Region: LON; smart00464 997761014762 Found in ATP-dependent protease La (LON); Region: LON; smart00464 997761014763 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761014764 Walker A motif; other site 997761014765 ATP binding site [chemical binding]; other site 997761014766 Walker B motif; other site 997761014767 arginine finger; other site 997761014768 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 997761014769 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 997761014770 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761014771 Walker A motif; other site 997761014772 ATP binding site [chemical binding]; other site 997761014773 Walker B motif; other site 997761014774 arginine finger; other site 997761014775 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 997761014776 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 997761014777 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 997761014778 active site 997761014779 metal binding site [ion binding]; metal-binding site 997761014780 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 997761014781 NodB motif; other site 997761014782 putative active site [active] 997761014783 putative catalytic site [active] 997761014784 Zn binding site [ion binding]; other site 997761014785 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 997761014786 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 997761014787 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 997761014788 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 997761014789 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 997761014790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761014791 Walker A motif; other site 997761014792 ATP binding site [chemical binding]; other site 997761014793 Walker B motif; other site 997761014794 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 997761014795 Clp protease; Region: CLP_protease; pfam00574 997761014796 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 997761014797 oligomer interface [polypeptide binding]; other site 997761014798 active site residues [active] 997761014799 trigger factor; Provisional; Region: tig; PRK01490 997761014800 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 997761014801 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 997761014802 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761014803 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761014804 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761014805 Spore germination protein; Region: Spore_permease; cl17796 997761014806 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 997761014807 active site 997761014808 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 997761014809 dimer interface [polypeptide binding]; other site 997761014810 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 997761014811 Ligand Binding Site [chemical binding]; other site 997761014812 Molecular Tunnel; other site 997761014813 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 997761014814 active site 997761014815 dimerization interface [polypeptide binding]; other site 997761014816 ribonuclease PH; Reviewed; Region: rph; PRK00173 997761014817 Ribonuclease PH; Region: RNase_PH_bact; cd11362 997761014818 hexamer interface [polypeptide binding]; other site 997761014819 active site 997761014820 Sporulation and spore germination; Region: Germane; pfam10646 997761014821 Spore germination protein [General function prediction only]; Region: COG5401 997761014822 Sporulation and spore germination; Region: Germane; pfam10646 997761014823 PAS domain S-box; Region: sensory_box; TIGR00229 997761014824 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761014825 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761014826 metal binding site [ion binding]; metal-binding site 997761014827 active site 997761014828 I-site; other site 997761014829 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 997761014830 tetramer interfaces [polypeptide binding]; other site 997761014831 binuclear metal-binding site [ion binding]; other site 997761014832 Methyltransferase domain; Region: Methyltransf_31; pfam13847 997761014833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761014834 S-adenosylmethionine binding site [chemical binding]; other site 997761014835 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 997761014836 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 997761014837 nucleotide binding site [chemical binding]; other site 997761014838 DNA-sulfur modification-associated; Region: DndB; cl17621 997761014839 DNA-sulfur modification-associated; Region: DndB; cl17621 997761014840 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761014841 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761014842 active site 997761014843 phosphorylation site [posttranslational modification] 997761014844 intermolecular recognition site; other site 997761014845 dimerization interface [polypeptide binding]; other site 997761014846 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761014847 DNA binding residues [nucleotide binding] 997761014848 dimerization interface [polypeptide binding]; other site 997761014849 Domain of unknown function (DUF4287); Region: DUF4287; pfam14117 997761014850 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 997761014851 putative hydrophobic ligand binding site [chemical binding]; other site 997761014852 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 997761014853 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761014854 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 997761014855 Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310 997761014856 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 997761014857 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 997761014858 tetramer interface [polypeptide binding]; other site 997761014859 heme binding pocket [chemical binding]; other site 997761014860 Cold-inducible protein YdjO; Region: YdjO; pfam14169 997761014861 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761014862 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761014863 DNA binding residues [nucleotide binding] 997761014864 dimerization interface [polypeptide binding]; other site 997761014865 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 997761014866 Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116 997761014867 transmembrane helices; other site 997761014868 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 997761014869 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 997761014870 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 997761014871 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761014872 S-adenosylmethionine binding site [chemical binding]; other site 997761014873 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 997761014874 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 997761014875 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 997761014876 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 997761014877 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 997761014878 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761014879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761014880 active site 997761014881 phosphorylation site [posttranslational modification] 997761014882 intermolecular recognition site; other site 997761014883 dimerization interface [polypeptide binding]; other site 997761014884 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761014885 DNA binding residues [nucleotide binding] 997761014886 dimerization interface [polypeptide binding]; other site 997761014887 Histidine kinase; Region: HisKA_3; pfam07730 997761014888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 997761014889 ATP binding site [chemical binding]; other site 997761014890 Mg2+ binding site [ion binding]; other site 997761014891 G-X-G motif; other site 997761014892 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 997761014893 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 997761014894 dimer interface [polypeptide binding]; other site 997761014895 active site 997761014896 CoA binding pocket [chemical binding]; other site 997761014897 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 997761014898 flagellar assembly protein H; Validated; Region: fliH; PRK05687 997761014899 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 997761014900 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 997761014901 Probable Catalytic site; other site 997761014902 metal-binding site 997761014903 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 997761014904 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 997761014905 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 997761014906 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 997761014907 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 997761014908 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 997761014909 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 997761014910 Probable Catalytic site; other site 997761014911 metal-binding site 997761014912 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 997761014913 active site 997761014914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761014915 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 997761014916 Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795 997761014917 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761014918 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 997761014919 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 997761014920 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 997761014921 homotetramer interface [polypeptide binding]; other site 997761014922 NADP-binding site; other site 997761014923 substrate binding site [chemical binding]; other site 997761014924 homodimer interface [polypeptide binding]; other site 997761014925 active site 997761014926 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 997761014927 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 997761014928 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 997761014929 NADP binding site [chemical binding]; other site 997761014930 active site 997761014931 putative substrate binding site [chemical binding]; other site 997761014932 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 997761014933 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 997761014934 active site 997761014935 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 997761014936 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761014937 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 997761014938 EcsC protein family; Region: EcsC; pfam12787 997761014939 Cupin domain; Region: Cupin_2; pfam07883 997761014940 O-Antigen ligase; Region: Wzy_C; pfam04932 997761014941 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 997761014942 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761014943 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761014944 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761014945 MarR family; Region: MarR; pfam01047 997761014946 MarR family; Region: MarR_2; cl17246 997761014947 ba3-like heme-copper oxidase subunit I. The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660 997761014948 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 997761014949 Low-spin heme binding site [chemical binding]; other site 997761014950 Subunit I/II interface [polypeptide binding]; other site 997761014951 Putative Q-pathway; other site 997761014952 Putative D-pathway homolog; other site 997761014953 Putative alternate electron transfer pathway; other site 997761014954 Putative water exit pathway; other site 997761014955 Binuclear center (active site) [active] 997761014956 Putative K-pathway homolog; other site 997761014957 Putative proton exit pathway; other site 997761014958 Subunit I/IIa interface [polypeptide binding]; other site 997761014959 Electron transfer pathway; other site 997761014960 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 997761014961 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 997761014962 Ion channel; Region: Ion_trans_2; pfam07885 997761014963 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 997761014964 TrkA-N domain; Region: TrkA_N; pfam02254 997761014965 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 997761014966 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 997761014967 Na binding site [ion binding]; other site 997761014968 Protein of unknown function, DUF485; Region: DUF485; pfam04341 997761014969 Putative transcription activator [Transcription]; Region: TenA; COG0819 997761014970 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 997761014971 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 997761014972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761014973 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761014974 putative substrate translocation pore; other site 997761014975 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 997761014976 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 997761014977 Zn2+ binding site [ion binding]; other site 997761014978 Mg2+ binding site [ion binding]; other site 997761014979 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 997761014980 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 997761014981 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 997761014982 glutaminase A; Region: Gln_ase; TIGR03814 997761014983 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761014984 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 997761014985 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 997761014986 TM-ABC transporter signature motif; other site 997761014987 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 997761014988 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 997761014989 Walker A/P-loop; other site 997761014990 ATP binding site [chemical binding]; other site 997761014991 Q-loop/lid; other site 997761014992 ABC transporter signature motif; other site 997761014993 Walker B; other site 997761014994 D-loop; other site 997761014995 H-loop/switch region; other site 997761014996 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 997761014997 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 997761014998 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 997761014999 putative ligand binding site [chemical binding]; other site 997761015000 Response regulator receiver domain; Region: Response_reg; pfam00072 997761015001 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015002 active site 997761015003 phosphorylation site [posttranslational modification] 997761015004 intermolecular recognition site; other site 997761015005 dimerization interface [polypeptide binding]; other site 997761015006 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761015007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761015008 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761015009 Cache domain; Region: Cache_1; pfam02743 997761015010 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761015011 dimerization interface [polypeptide binding]; other site 997761015012 Histidine kinase; Region: His_kinase; pfam06580 997761015013 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761015014 ATP binding site [chemical binding]; other site 997761015015 Mg2+ binding site [ion binding]; other site 997761015016 G-X-G motif; other site 997761015017 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 997761015018 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 997761015019 ligand binding site [chemical binding]; other site 997761015020 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 997761015021 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761015022 putative DNA binding site [nucleotide binding]; other site 997761015023 putative Zn2+ binding site [ion binding]; other site 997761015024 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 997761015025 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761015026 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 997761015027 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761015028 homodimer interface [polypeptide binding]; other site 997761015029 catalytic residue [active] 997761015030 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 997761015031 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761015032 NAD(P) binding site [chemical binding]; other site 997761015033 active site 997761015034 Helix-turn-helix domain; Region: HTH_31; pfam13560 997761015035 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761015036 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761015037 threonine dehydratase; Validated; Region: PRK08639 997761015038 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 997761015039 tetramer interface [polypeptide binding]; other site 997761015040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761015041 catalytic residue [active] 997761015042 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 997761015043 putative Ile/Val binding site [chemical binding]; other site 997761015044 S-layer homology domain; Region: SLH; pfam00395 997761015045 S-layer homology domain; Region: SLH; pfam00395 997761015046 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 997761015047 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 997761015048 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761015049 MarR family; Region: MarR; pfam01047 997761015050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761015051 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761015052 putative substrate translocation pore; other site 997761015053 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 997761015054 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 997761015055 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 997761015056 active site 997761015057 HIGH motif; other site 997761015058 nucleotide binding site [chemical binding]; other site 997761015059 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 997761015060 active site 997761015061 KMSKS motif; other site 997761015062 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 997761015063 tRNA binding surface [nucleotide binding]; other site 997761015064 anticodon binding site; other site 997761015065 Ferredoxin [Energy production and conversion]; Region: COG1146 997761015066 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 997761015067 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 997761015068 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761015069 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761015070 dimerization interface [polypeptide binding]; other site 997761015071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 997761015072 MOSC domain; Region: MOSC; pfam03473 997761015073 3-alpha domain; Region: 3-alpha; pfam03475 997761015074 RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137 997761015075 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 997761015076 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 997761015077 Protein of unknown function (DUF2573); Region: DUF2573; pfam10835 997761015078 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 997761015079 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761015080 NAD(P) binding site [chemical binding]; other site 997761015081 active site 997761015082 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 997761015083 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 997761015084 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 997761015085 nudix motif; other site 997761015086 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 997761015087 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 997761015088 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 997761015089 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 997761015090 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 997761015091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761015092 Walker A/P-loop; other site 997761015093 ATP binding site [chemical binding]; other site 997761015094 Q-loop/lid; other site 997761015095 ABC transporter signature motif; other site 997761015096 Walker B; other site 997761015097 D-loop; other site 997761015098 H-loop/switch region; other site 997761015099 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 997761015100 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 997761015101 serpin-like protein; Provisional; Region: PHA02660 997761015102 reactive center loop; other site 997761015103 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 997761015104 serpin-like protein; Provisional; Region: PHA02660 997761015105 reactive center loop; other site 997761015106 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 997761015107 Cysteine dioxygenase type I; Region: CDO_I; pfam05995 997761015108 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761015109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015110 active site 997761015111 phosphorylation site [posttranslational modification] 997761015112 intermolecular recognition site; other site 997761015113 dimerization interface [polypeptide binding]; other site 997761015114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761015115 DNA binding site [nucleotide binding] 997761015116 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 997761015117 active site 997761015118 DinB superfamily; Region: DinB_2; pfam12867 997761015119 metal-dependent hydrolase; Provisional; Region: PRK13291 997761015120 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 997761015121 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 997761015122 DNA binding residues [nucleotide binding] 997761015123 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 997761015124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761015125 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761015126 putative substrate translocation pore; other site 997761015127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761015128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761015129 putative substrate translocation pore; other site 997761015130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761015131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 997761015132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 997761015133 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 997761015134 dimerization interface [polypeptide binding]; other site 997761015135 histidinol-phosphatase; Provisional; Region: PRK07328 997761015136 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 997761015137 active site 997761015138 dimer interface [polypeptide binding]; other site 997761015139 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 997761015140 active site 997761015141 catalytic triad [active] 997761015142 oxyanion hole [active] 997761015143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015144 Response regulator receiver domain; Region: Response_reg; pfam00072 997761015145 active site 997761015146 phosphorylation site [posttranslational modification] 997761015147 intermolecular recognition site; other site 997761015148 dimerization interface [polypeptide binding]; other site 997761015149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761015150 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761015151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761015152 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761015153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761015154 dimer interface [polypeptide binding]; other site 997761015155 conserved gate region; other site 997761015156 putative PBP binding loops; other site 997761015157 ABC-ATPase subunit interface; other site 997761015158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761015159 dimer interface [polypeptide binding]; other site 997761015160 conserved gate region; other site 997761015161 putative PBP binding loops; other site 997761015162 ABC-ATPase subunit interface; other site 997761015163 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761015164 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761015165 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 997761015166 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 997761015167 Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264 997761015168 active site turn [active] 997761015169 phosphorylation site [posttranslational modification] 997761015170 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 997761015171 HPr interaction site; other site 997761015172 glycerol kinase (GK) interaction site [polypeptide binding]; other site 997761015173 active site 997761015174 phosphorylation site [posttranslational modification] 997761015175 transcriptional antiterminator BglG; Provisional; Region: PRK09772 997761015176 CAT RNA binding domain; Region: CAT_RBD; smart01061 997761015177 PRD domain; Region: PRD; pfam00874 997761015178 PRD domain; Region: PRD; pfam00874 997761015179 Predicted transcriptional regulators [Transcription]; Region: COG1695 997761015180 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 997761015181 hypothetical protein; Validated; Region: PRK07668 997761015182 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 997761015183 active site 997761015184 catalytic site [active] 997761015185 substrate binding site [chemical binding]; other site 997761015186 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761015187 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761015188 S-layer homology domain; Region: SLH; pfam00395 997761015189 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 997761015190 Histidine kinase; Region: HisKA_3; pfam07730 997761015191 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761015192 ATP binding site [chemical binding]; other site 997761015193 Mg2+ binding site [ion binding]; other site 997761015194 G-X-G motif; other site 997761015195 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761015196 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015197 active site 997761015198 phosphorylation site [posttranslational modification] 997761015199 intermolecular recognition site; other site 997761015200 dimerization interface [polypeptide binding]; other site 997761015201 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761015202 DNA binding residues [nucleotide binding] 997761015203 dimerization interface [polypeptide binding]; other site 997761015204 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761015205 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761015206 Beta-lactamase; Region: Beta-lactamase; pfam00144 997761015207 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 997761015208 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 997761015209 Histidine kinase; Region: HisKA_3; pfam07730 997761015210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761015211 ATP binding site [chemical binding]; other site 997761015212 Mg2+ binding site [ion binding]; other site 997761015213 G-X-G motif; other site 997761015214 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761015215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015216 active site 997761015217 phosphorylation site [posttranslational modification] 997761015218 intermolecular recognition site; other site 997761015219 dimerization interface [polypeptide binding]; other site 997761015220 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761015221 DNA binding residues [nucleotide binding] 997761015222 dimerization interface [polypeptide binding]; other site 997761015223 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 997761015224 heme-binding site [chemical binding]; other site 997761015225 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761015226 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761015227 dimer interface [polypeptide binding]; other site 997761015228 putative CheW interface [polypeptide binding]; other site 997761015229 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761015230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015231 active site 997761015232 phosphorylation site [posttranslational modification] 997761015233 intermolecular recognition site; other site 997761015234 dimerization interface [polypeptide binding]; other site 997761015235 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761015236 DNA binding site [nucleotide binding] 997761015237 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 997761015238 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761015239 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761015240 dimer interface [polypeptide binding]; other site 997761015241 phosphorylation site [posttranslational modification] 997761015242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761015243 ATP binding site [chemical binding]; other site 997761015244 Mg2+ binding site [ion binding]; other site 997761015245 G-X-G motif; other site 997761015246 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 997761015247 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 997761015248 Methyltransferase domain; Region: Methyltransf_23; pfam13489 997761015249 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761015250 S-adenosylmethionine binding site [chemical binding]; other site 997761015251 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 997761015252 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761015253 putative active site [active] 997761015254 heme pocket [chemical binding]; other site 997761015255 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761015256 dimer interface [polypeptide binding]; other site 997761015257 phosphorylation site [posttranslational modification] 997761015258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761015259 ATP binding site [chemical binding]; other site 997761015260 Mg2+ binding site [ion binding]; other site 997761015261 G-X-G motif; other site 997761015262 UDP-glucose 4-epimerase; Region: PLN02240 997761015263 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 997761015264 NAD binding site [chemical binding]; other site 997761015265 homodimer interface [polypeptide binding]; other site 997761015266 active site 997761015267 substrate binding site [chemical binding]; other site 997761015268 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 997761015269 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 997761015270 Protein of unknown function (DUF466); Region: DUF466; pfam04328 997761015271 carbon starvation protein A; Provisional; Region: PRK15015 997761015272 Carbon starvation protein CstA; Region: CstA; pfam02554 997761015273 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 997761015274 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 997761015275 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015276 active site 997761015277 phosphorylation site [posttranslational modification] 997761015278 intermolecular recognition site; other site 997761015279 dimerization interface [polypeptide binding]; other site 997761015280 LytTr DNA-binding domain; Region: LytTR; smart00850 997761015281 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 997761015282 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 997761015283 Histidine kinase; Region: His_kinase; pfam06580 997761015284 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761015285 ATP binding site [chemical binding]; other site 997761015286 Mg2+ binding site [ion binding]; other site 997761015287 G-X-G motif; other site 997761015288 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 997761015289 active site 997761015290 metal binding site [ion binding]; metal-binding site 997761015291 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 997761015292 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 997761015293 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 997761015294 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 997761015295 putative active site [active] 997761015296 putative metal binding site [ion binding]; other site 997761015297 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 997761015298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761015299 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761015300 putative substrate translocation pore; other site 997761015301 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761015302 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761015303 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761015304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761015305 dimer interface [polypeptide binding]; other site 997761015306 conserved gate region; other site 997761015307 putative PBP binding loops; other site 997761015308 ABC-ATPase subunit interface; other site 997761015309 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 997761015310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761015311 dimer interface [polypeptide binding]; other site 997761015312 conserved gate region; other site 997761015313 putative PBP binding loops; other site 997761015314 ABC-ATPase subunit interface; other site 997761015315 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761015316 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761015317 dimerization interface [polypeptide binding]; other site 997761015318 Histidine kinase; Region: His_kinase; pfam06580 997761015319 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761015320 ATP binding site [chemical binding]; other site 997761015321 Mg2+ binding site [ion binding]; other site 997761015322 G-X-G motif; other site 997761015323 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015324 Response regulator receiver domain; Region: Response_reg; pfam00072 997761015325 active site 997761015326 phosphorylation site [posttranslational modification] 997761015327 intermolecular recognition site; other site 997761015328 dimerization interface [polypeptide binding]; other site 997761015329 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761015330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761015331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761015332 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 997761015333 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 997761015334 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 997761015335 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 997761015336 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 997761015337 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 997761015338 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761015339 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015340 active site 997761015341 phosphorylation site [posttranslational modification] 997761015342 intermolecular recognition site; other site 997761015343 dimerization interface [polypeptide binding]; other site 997761015344 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761015345 DNA binding site [nucleotide binding] 997761015346 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 997761015347 homodimer interface [polypeptide binding]; other site 997761015348 substrate-cofactor binding pocket; other site 997761015349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761015350 catalytic residue [active] 997761015351 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 997761015352 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 997761015353 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 997761015354 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 997761015355 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761015356 non-specific DNA binding site [nucleotide binding]; other site 997761015357 salt bridge; other site 997761015358 sequence-specific DNA binding site [nucleotide binding]; other site 997761015359 Anti-repressor SinI; Region: SinI; pfam08671 997761015360 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 997761015361 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761015362 non-specific DNA binding site [nucleotide binding]; other site 997761015363 salt bridge; other site 997761015364 sequence-specific DNA binding site [nucleotide binding]; other site 997761015365 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 997761015366 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761015367 sequence-specific DNA binding site [nucleotide binding]; other site 997761015368 salt bridge; other site 997761015369 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 997761015370 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 997761015371 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 997761015372 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 997761015373 Right handed beta helix region; Region: Beta_helix; pfam13229 997761015374 Galactose oxidase, central domain; Region: Kelch_3; cl02701 997761015375 Kelch domain; Region: Kelch; smart00612 997761015376 Galactose oxidase, central domain; Region: Kelch_4; pfam13418 997761015377 Kelch domain; Region: Kelch; smart00612 997761015378 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 997761015379 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 997761015380 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 997761015381 trimer interface [polypeptide binding]; other site 997761015382 active site 997761015383 substrate binding site [chemical binding]; other site 997761015384 CoA binding site [chemical binding]; other site 997761015385 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 997761015386 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 997761015387 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 997761015388 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 997761015389 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 997761015390 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 997761015391 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 997761015392 active site 997761015393 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 997761015394 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 997761015395 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 997761015396 active site 997761015397 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 997761015398 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 997761015399 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 997761015400 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 997761015401 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 997761015402 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 997761015403 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761015404 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761015405 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 997761015406 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087 997761015407 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 997761015408 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 997761015409 Bacterial sugar transferase; Region: Bac_transf; pfam02397 997761015410 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 997761015411 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 997761015412 active site 997761015413 tetramer interface; other site 997761015414 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 997761015415 Chain length determinant protein; Region: Wzz; cl15801 997761015416 putative glycosyl transferase; Provisional; Region: PRK10307 997761015417 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 997761015418 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 997761015419 putative trimer interface [polypeptide binding]; other site 997761015420 putative active site [active] 997761015421 putative substrate binding site [chemical binding]; other site 997761015422 putative CoA binding site [chemical binding]; other site 997761015423 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761015424 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 997761015425 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 997761015426 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761015427 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 997761015428 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 997761015429 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 997761015430 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 997761015431 NADP-binding site; other site 997761015432 homotetramer interface [polypeptide binding]; other site 997761015433 substrate binding site [chemical binding]; other site 997761015434 homodimer interface [polypeptide binding]; other site 997761015435 active site 997761015436 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 997761015437 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 997761015438 NADP binding site [chemical binding]; other site 997761015439 active site 997761015440 putative substrate binding site [chemical binding]; other site 997761015441 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 997761015442 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 997761015443 Chain length determinant protein; Region: Wzz; cl15801 997761015444 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 997761015445 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 997761015446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761015447 sequence-specific DNA binding site [nucleotide binding]; other site 997761015448 salt bridge; other site 997761015449 glutamine synthetase, type I; Region: GlnA; TIGR00653 997761015450 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 997761015451 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 997761015452 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 997761015453 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 997761015454 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261 997761015455 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 997761015456 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 997761015457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761015458 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761015459 dimerization interface [polypeptide binding]; other site 997761015460 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761015461 dimer interface [polypeptide binding]; other site 997761015462 phosphorylation site [posttranslational modification] 997761015463 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761015464 ATP binding site [chemical binding]; other site 997761015465 Mg2+ binding site [ion binding]; other site 997761015466 G-X-G motif; other site 997761015467 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761015468 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015469 active site 997761015470 phosphorylation site [posttranslational modification] 997761015471 intermolecular recognition site; other site 997761015472 dimerization interface [polypeptide binding]; other site 997761015473 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761015474 DNA binding site [nucleotide binding] 997761015475 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 997761015476 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 997761015477 protein binding site [polypeptide binding]; other site 997761015478 YugN-like family; Region: YugN; pfam08868 997761015479 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 997761015480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 997761015481 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 997761015482 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 997761015483 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 997761015484 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 997761015485 active site 997761015486 dimer interface [polypeptide binding]; other site 997761015487 motif 1; other site 997761015488 motif 2; other site 997761015489 motif 3; other site 997761015490 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 997761015491 anticodon binding site; other site 997761015492 YtxC-like family; Region: YtxC; pfam08812 997761015493 Predicted membrane protein [Function unknown]; Region: COG3371 997761015494 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761015495 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761015496 metal binding site [ion binding]; metal-binding site 997761015497 active site 997761015498 I-site; other site 997761015499 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 997761015500 binding surface 997761015501 TPR motif; other site 997761015502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 997761015503 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 997761015504 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761015505 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 997761015506 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 997761015507 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761015508 FeS/SAM binding site; other site 997761015509 Beta-lactamase class D [Defense mechanisms]; Region: COG2602 997761015510 cystathionine gamma-synthase; Reviewed; Region: PRK08247 997761015511 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 997761015512 homodimer interface [polypeptide binding]; other site 997761015513 substrate-cofactor binding pocket; other site 997761015514 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761015515 catalytic residue [active] 997761015516 Homoserine O-succinyltransferase; Region: HTS; pfam04204 997761015517 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 997761015518 proposed active site lysine [active] 997761015519 conserved cys residue [active] 997761015520 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 997761015521 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 997761015522 oligomer interface [polypeptide binding]; other site 997761015523 metal binding site [ion binding]; metal-binding site 997761015524 metal binding site [ion binding]; metal-binding site 997761015525 putative Cl binding site [ion binding]; other site 997761015526 aspartate ring; other site 997761015527 basic sphincter; other site 997761015528 hydrophobic gate; other site 997761015529 periplasmic entrance; other site 997761015530 HRDC domain; Region: HRDC; pfam00570 997761015531 Protein of unknown function (DUF3055); Region: DUF3055; pfam11256 997761015532 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 997761015533 Predicted transcriptional regulator [Transcription]; Region: COG4189 997761015534 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761015535 putative DNA binding site [nucleotide binding]; other site 997761015536 dimerization interface [polypeptide binding]; other site 997761015537 putative Zn2+ binding site [ion binding]; other site 997761015538 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 997761015539 5'-3' exonuclease; Region: 53EXOc; smart00475 997761015540 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 997761015541 active site 997761015542 metal binding site 1 [ion binding]; metal-binding site 997761015543 putative 5' ssDNA interaction site; other site 997761015544 metal binding site 3; metal-binding site 997761015545 metal binding site 2 [ion binding]; metal-binding site 997761015546 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 997761015547 putative DNA binding site [nucleotide binding]; other site 997761015548 putative metal binding site [ion binding]; other site 997761015549 Cupin domain; Region: Cupin_2; pfam07883 997761015550 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761015551 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761015552 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761015553 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761015554 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761015555 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761015556 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761015557 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761015558 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761015559 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 997761015560 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761015561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761015562 homodimer interface [polypeptide binding]; other site 997761015563 catalytic residue [active] 997761015564 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 997761015565 ArsC family; Region: ArsC; pfam03960 997761015566 putative ArsC-like catalytic residues; other site 997761015567 putative TRX-like catalytic residues [active] 997761015568 Uncharacterized conserved protein [Function unknown]; Region: COG1434 997761015569 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 997761015570 putative active site [active] 997761015571 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 997761015572 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 997761015573 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 997761015574 active site 997761015575 cob(I)alamin adenosyltransferase [Coenzyme transport and metabolism]; Region: COG2096 997761015576 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 997761015577 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 997761015578 homotrimer interface [polypeptide binding]; other site 997761015579 Walker A motif; other site 997761015580 GTP binding site [chemical binding]; other site 997761015581 Walker B motif; other site 997761015582 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 997761015583 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 997761015584 putative dimer interface [polypeptide binding]; other site 997761015585 active site pocket [active] 997761015586 putative cataytic base [active] 997761015587 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 997761015588 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 997761015589 Walker A/P-loop; other site 997761015590 ATP binding site [chemical binding]; other site 997761015591 Q-loop/lid; other site 997761015592 ABC transporter signature motif; other site 997761015593 Walker B; other site 997761015594 D-loop; other site 997761015595 H-loop/switch region; other site 997761015596 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 997761015597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761015598 ABC-ATPase subunit interface; other site 997761015599 dimer interface [polypeptide binding]; other site 997761015600 putative PBP binding regions; other site 997761015601 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 997761015602 Periplasmic binding protein YvrC. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143 997761015603 putative binding site residues; other site 997761015604 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 997761015605 hypothetical protein; Validated; Region: PRK07682 997761015606 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761015607 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761015608 homodimer interface [polypeptide binding]; other site 997761015609 catalytic residue [active] 997761015610 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 997761015611 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 997761015612 AsnC family; Region: AsnC_trans_reg; pfam01037 997761015613 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 997761015614 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 997761015615 dimer interface [polypeptide binding]; other site 997761015616 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761015617 catalytic residue [active] 997761015618 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 997761015619 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 997761015620 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 997761015621 Membrane protein of unknown function; Region: DUF360; pfam04020 997761015622 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 997761015623 classical (c) SDRs; Region: SDR_c; cd05233 997761015624 NAD(P) binding site [chemical binding]; other site 997761015625 active site 997761015626 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761015627 DNA-binding site [nucleotide binding]; DNA binding site 997761015628 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 997761015629 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761015630 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761015631 homodimer interface [polypeptide binding]; other site 997761015632 catalytic residue [active] 997761015633 Colicin V production protein; Region: Colicin_V; pfam02674 997761015634 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 997761015635 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 997761015636 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 997761015637 dimer interface [polypeptide binding]; other site 997761015638 motif 1; other site 997761015639 active site 997761015640 motif 2; other site 997761015641 motif 3; other site 997761015642 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 997761015643 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 997761015644 Ferritin-like domain; Region: Ferritin; pfam00210 997761015645 ferroxidase diiron center [ion binding]; other site 997761015646 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 997761015647 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 997761015648 Uncharacterized conserved protein [Function unknown]; Region: COG2128 997761015649 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 997761015650 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 997761015651 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 997761015652 catalytic triad [active] 997761015653 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 997761015654 active site 997761015655 SAM binding site [chemical binding]; other site 997761015656 homodimer interface [polypeptide binding]; other site 997761015657 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 997761015658 active site 997761015659 SAM binding site [chemical binding]; other site 997761015660 homodimer interface [polypeptide binding]; other site 997761015661 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 997761015662 active site 997761015663 putative homodimer interface [polypeptide binding]; other site 997761015664 SAM binding site [chemical binding]; other site 997761015665 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 997761015666 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 997761015667 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 997761015668 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 997761015669 Precorrin-8X methylmutase; Region: CbiC; pfam02570 997761015670 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 997761015671 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 997761015672 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 997761015673 putative active site [active] 997761015674 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 997761015675 putative active site [active] 997761015676 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 997761015677 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761015678 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761015679 active site 997761015680 catalytic tetrad [active] 997761015681 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761015682 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761015683 metal binding site [ion binding]; metal-binding site 997761015684 active site 997761015685 I-site; other site 997761015686 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 997761015687 CopC domain; Region: CopC; pfam04234 997761015688 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088 997761015689 ATP cone domain; Region: ATP-cone; pfam03477 997761015690 Class I ribonucleotide reductase; Region: RNR_I; cd01679 997761015691 active site 997761015692 dimer interface [polypeptide binding]; other site 997761015693 catalytic residues [active] 997761015694 effector binding site; other site 997761015695 R2 peptide binding site; other site 997761015696 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 997761015697 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 997761015698 dimer interface [polypeptide binding]; other site 997761015699 putative radical transfer pathway; other site 997761015700 diiron center [ion binding]; other site 997761015701 tyrosyl radical; other site 997761015702 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 997761015703 putative binding surface; other site 997761015704 active site 997761015705 Response regulator receiver domain; Region: Response_reg; pfam00072 997761015706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015707 active site 997761015708 phosphorylation site [posttranslational modification] 997761015709 intermolecular recognition site; other site 997761015710 dimerization interface [polypeptide binding]; other site 997761015711 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761015712 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761015713 metal binding site [ion binding]; metal-binding site 997761015714 active site 997761015715 I-site; other site 997761015716 Response regulator receiver domain; Region: Response_reg; pfam00072 997761015717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015718 active site 997761015719 phosphorylation site [posttranslational modification] 997761015720 intermolecular recognition site; other site 997761015721 dimerization interface [polypeptide binding]; other site 997761015722 Response regulator receiver domain; Region: Response_reg; pfam00072 997761015723 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015724 active site 997761015725 phosphorylation site [posttranslational modification] 997761015726 intermolecular recognition site; other site 997761015727 dimerization interface [polypeptide binding]; other site 997761015728 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 997761015729 putative active site pocket [active] 997761015730 dimerization interface [polypeptide binding]; other site 997761015731 putative catalytic residue [active] 997761015732 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 997761015733 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 997761015734 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 997761015735 putative active site [active] 997761015736 Mor transcription activator family; Region: Mor; cl02360 997761015737 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 997761015738 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 997761015739 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 997761015740 active site 997761015741 ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221 997761015742 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761015743 substrate binding pocket [chemical binding]; other site 997761015744 membrane-bound complex binding site; other site 997761015745 hinge residues; other site 997761015746 Protein of unknown function (DUF342); Region: DUF342; pfam03961 997761015747 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 997761015748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761015749 dimer interface [polypeptide binding]; other site 997761015750 conserved gate region; other site 997761015751 ABC-ATPase subunit interface; other site 997761015752 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 997761015753 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 997761015754 Walker A/P-loop; other site 997761015755 ATP binding site [chemical binding]; other site 997761015756 Q-loop/lid; other site 997761015757 ABC transporter signature motif; other site 997761015758 Walker B; other site 997761015759 D-loop; other site 997761015760 H-loop/switch region; other site 997761015761 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 997761015762 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 997761015763 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 997761015764 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 997761015765 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 997761015766 Walker A/P-loop; other site 997761015767 ATP binding site [chemical binding]; other site 997761015768 Q-loop/lid; other site 997761015769 ABC transporter signature motif; other site 997761015770 Walker B; other site 997761015771 D-loop; other site 997761015772 H-loop/switch region; other site 997761015773 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 997761015774 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 997761015775 active site 997761015776 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 997761015777 3D domain; Region: 3D; cl01439 997761015778 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 997761015779 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 997761015780 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 997761015781 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761015782 putative active site [active] 997761015783 heme pocket [chemical binding]; other site 997761015784 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761015785 ATP binding site [chemical binding]; other site 997761015786 Mg2+ binding site [ion binding]; other site 997761015787 G-X-G motif; other site 997761015788 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 997761015789 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015790 active site 997761015791 phosphorylation site [posttranslational modification] 997761015792 intermolecular recognition site; other site 997761015793 dimerization interface [polypeptide binding]; other site 997761015794 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 997761015795 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 997761015796 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 997761015797 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 997761015798 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 997761015799 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 997761015800 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 997761015801 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761015802 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761015803 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761015804 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761015805 lysine transporter; Provisional; Region: PRK10836 997761015806 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 997761015807 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 997761015808 Walker A/P-loop; other site 997761015809 ATP binding site [chemical binding]; other site 997761015810 Q-loop/lid; other site 997761015811 ABC transporter signature motif; other site 997761015812 Walker B; other site 997761015813 D-loop; other site 997761015814 H-loop/switch region; other site 997761015815 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 997761015816 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 997761015817 hypothetical protein; Provisional; Region: PRK06185 997761015818 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 997761015819 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 997761015820 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 997761015821 catalytic site [active] 997761015822 PrcB C-terminal; Region: PrcB_C; pfam14343 997761015823 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 997761015824 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 997761015825 putative ligand binding site [chemical binding]; other site 997761015826 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761015827 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 997761015828 TM-ABC transporter signature motif; other site 997761015829 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 997761015830 putative active site [active] 997761015831 putative catalytic site [active] 997761015832 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 997761015833 PLD-like domain; Region: PLDc_2; pfam13091 997761015834 putative active site [active] 997761015835 putative catalytic site [active] 997761015836 Peptidase family M23; Region: Peptidase_M23; pfam01551 997761015837 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 997761015838 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 997761015839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761015840 dimer interface [polypeptide binding]; other site 997761015841 conserved gate region; other site 997761015842 putative PBP binding loops; other site 997761015843 ABC-ATPase subunit interface; other site 997761015844 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 997761015845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761015846 dimer interface [polypeptide binding]; other site 997761015847 conserved gate region; other site 997761015848 putative PBP binding loops; other site 997761015849 ABC-ATPase subunit interface; other site 997761015850 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 997761015851 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761015852 substrate binding pocket [chemical binding]; other site 997761015853 membrane-bound complex binding site; other site 997761015854 hinge residues; other site 997761015855 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 997761015856 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 997761015857 Walker A/P-loop; other site 997761015858 ATP binding site [chemical binding]; other site 997761015859 Q-loop/lid; other site 997761015860 ABC transporter signature motif; other site 997761015861 Walker B; other site 997761015862 D-loop; other site 997761015863 H-loop/switch region; other site 997761015864 S-layer homology domain; Region: SLH; pfam00395 997761015865 Protein of unknown function (DUF2845); Region: DUF2845; pfam11006 997761015866 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 997761015867 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 997761015868 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 997761015869 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 997761015870 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 997761015871 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 997761015872 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 997761015873 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761015874 putative active site [active] 997761015875 heme pocket [chemical binding]; other site 997761015876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761015877 dimer interface [polypeptide binding]; other site 997761015878 phosphorylation site [posttranslational modification] 997761015879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761015880 ATP binding site [chemical binding]; other site 997761015881 Mg2+ binding site [ion binding]; other site 997761015882 G-X-G motif; other site 997761015883 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 997761015884 Protein of unknown function (DUF458); Region: DUF458; pfam04308 997761015885 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 997761015886 active site 997761015887 zinc binding site [ion binding]; other site 997761015888 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 997761015889 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 997761015890 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 997761015891 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 997761015892 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761015893 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761015894 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761015895 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761015896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761015897 dimer interface [polypeptide binding]; other site 997761015898 conserved gate region; other site 997761015899 putative PBP binding loops; other site 997761015900 ABC-ATPase subunit interface; other site 997761015901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761015902 dimer interface [polypeptide binding]; other site 997761015903 conserved gate region; other site 997761015904 putative PBP binding loops; other site 997761015905 ABC-ATPase subunit interface; other site 997761015906 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761015907 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761015908 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761015909 Histidine kinase; Region: His_kinase; pfam06580 997761015910 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761015911 ATP binding site [chemical binding]; other site 997761015912 Mg2+ binding site [ion binding]; other site 997761015913 G-X-G motif; other site 997761015914 YheO-like PAS domain; Region: PAS_6; pfam08348 997761015915 HTH domain; Region: HTH_22; pfam13309 997761015916 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 997761015917 D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297 997761015918 active site 997761015919 putative substrate binding pocket [chemical binding]; other site 997761015920 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 997761015921 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 997761015922 homotrimer interaction site [polypeptide binding]; other site 997761015923 putative active site [active] 997761015924 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 997761015925 FAD binding domain; Region: FAD_binding_3; pfam01494 997761015926 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 997761015927 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 997761015928 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 997761015929 active site 997761015930 non-prolyl cis peptide bond; other site 997761015931 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 997761015932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761015933 dimer interface [polypeptide binding]; other site 997761015934 conserved gate region; other site 997761015935 putative PBP binding loops; other site 997761015936 ABC-ATPase subunit interface; other site 997761015937 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 997761015938 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 997761015939 Walker A/P-loop; other site 997761015940 ATP binding site [chemical binding]; other site 997761015941 Q-loop/lid; other site 997761015942 ABC transporter signature motif; other site 997761015943 Walker B; other site 997761015944 D-loop; other site 997761015945 H-loop/switch region; other site 997761015946 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 997761015947 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 997761015948 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 997761015949 dimer interface [polypeptide binding]; other site 997761015950 FMN binding site [chemical binding]; other site 997761015951 NADPH bind site [chemical binding]; other site 997761015952 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 997761015953 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 997761015954 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 997761015955 active site 997761015956 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 997761015957 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 997761015958 Fn3 associated; Region: Fn3_assoc; pfam13287 997761015959 Fn3 associated; Region: Fn3_assoc; pfam13287 997761015960 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 997761015961 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 997761015962 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 997761015963 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 997761015964 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761015965 TM-ABC transporter signature motif; other site 997761015966 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 997761015967 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 997761015968 Walker A/P-loop; other site 997761015969 ATP binding site [chemical binding]; other site 997761015970 Q-loop/lid; other site 997761015971 ABC transporter signature motif; other site 997761015972 Walker B; other site 997761015973 D-loop; other site 997761015974 H-loop/switch region; other site 997761015975 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 997761015976 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 997761015977 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 997761015978 ligand binding site [chemical binding]; other site 997761015979 calcium binding site [ion binding]; other site 997761015980 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 997761015981 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 997761015982 putative ligand binding site [chemical binding]; other site 997761015983 Cache domain; Region: Cache_1; pfam02743 997761015984 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761015985 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761015986 dimerization interface [polypeptide binding]; other site 997761015987 Histidine kinase; Region: His_kinase; pfam06580 997761015988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761015989 ATP binding site [chemical binding]; other site 997761015990 Mg2+ binding site [ion binding]; other site 997761015991 G-X-G motif; other site 997761015992 Response regulator receiver domain; Region: Response_reg; pfam00072 997761015993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761015994 active site 997761015995 phosphorylation site [posttranslational modification] 997761015996 intermolecular recognition site; other site 997761015997 dimerization interface [polypeptide binding]; other site 997761015998 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761015999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761016000 TIGR02452 family protein; Region: TIGR02452 997761016001 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 997761016002 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 997761016003 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 997761016004 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 997761016005 active site 997761016006 nucleotide binding site [chemical binding]; other site 997761016007 HIGH motif; other site 997761016008 KMSKS motif; other site 997761016009 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 997761016010 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 997761016011 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 997761016012 nudix motif; other site 997761016013 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 997761016014 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 997761016015 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 997761016016 Leucine rich repeat; Region: LRR_8; pfam13855 997761016017 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761016018 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761016019 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 997761016020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761016021 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 997761016022 Walker A motif; other site 997761016023 ATP binding site [chemical binding]; other site 997761016024 Walker B motif; other site 997761016025 arginine finger; other site 997761016026 tellurium resistance terB-like protein; Region: terB_like; cd07177 997761016027 metal binding site [ion binding]; metal-binding site 997761016028 Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516 997761016029 Protein of unknown function (DUF1470); Region: DUF1470; pfam07336 997761016030 CGNR zinc finger; Region: zf-CGNR; pfam11706 997761016031 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 997761016032 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 997761016033 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 997761016034 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 997761016035 DNA binding residues [nucleotide binding] 997761016036 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 997761016037 Predicted transcriptional regulators [Transcription]; Region: COG1695 997761016038 Transcriptional regulator PadR-like family; Region: PadR; cl17335 997761016039 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761016040 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761016041 metal binding site [ion binding]; metal-binding site 997761016042 active site 997761016043 I-site; other site 997761016044 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 997761016045 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 997761016046 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 997761016047 Heat induced stress protein YflT; Region: YflT; pfam11181 997761016048 conserved domain; Region: TIGR02271 997761016049 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 997761016050 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761016051 ABC-ATPase subunit interface; other site 997761016052 dimer interface [polypeptide binding]; other site 997761016053 putative PBP binding regions; other site 997761016054 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 997761016055 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761016056 ABC-ATPase subunit interface; other site 997761016057 dimer interface [polypeptide binding]; other site 997761016058 putative PBP binding regions; other site 997761016059 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 997761016060 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 997761016061 intersubunit interface [polypeptide binding]; other site 997761016062 Fic family protein [Function unknown]; Region: COG3177 997761016063 Fic/DOC family; Region: Fic; pfam02661 997761016064 MarR family; Region: MarR_2; cl17246 997761016065 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 997761016066 Chorismate mutase type II; Region: CM_2; cl00693 997761016067 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 997761016068 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761016069 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761016070 active site 997761016071 catalytic tetrad [active] 997761016072 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761016073 Coenzyme A binding pocket [chemical binding]; other site 997761016074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761016075 Coenzyme A binding pocket [chemical binding]; other site 997761016076 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 997761016077 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 997761016078 dimer interface [polypeptide binding]; other site 997761016079 active site 997761016080 metal binding site [ion binding]; metal-binding site 997761016081 UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284 997761016082 UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193 997761016083 substrate binding site; other site 997761016084 dimerization interface; other site 997761016085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761016086 Coenzyme A binding pocket [chemical binding]; other site 997761016087 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 997761016088 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 997761016089 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 997761016090 putative transposase OrfB; Reviewed; Region: PHA02517 997761016091 HTH-like domain; Region: HTH_21; pfam13276 997761016092 Integrase core domain; Region: rve; pfam00665 997761016093 Integrase core domain; Region: rve_3; pfam13683 997761016094 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 997761016095 Transposase; Region: HTH_Tnp_1; pfam01527 997761016096 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761016097 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 997761016098 substrate binding site [chemical binding]; other site 997761016099 Mrr N-terminal domain; Region: Mrr_N; pfam14338 997761016100 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 997761016101 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 997761016102 Competence protein J (ComJ); Region: ComJ; pfam11033 997761016103 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 997761016104 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 997761016105 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761016106 Interdomain contacts; other site 997761016107 Cytokine receptor motif; other site 997761016108 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761016109 Interdomain contacts; other site 997761016110 Cytokine receptor motif; other site 997761016111 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 997761016112 dockerin binding interface; other site 997761016113 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 997761016114 iron-sulfur cluster [ion binding]; other site 997761016115 [2Fe-2S] cluster binding site [ion binding]; other site 997761016116 intracellular protease, PfpI family; Region: PfpI; TIGR01382 997761016117 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 997761016118 conserved cys residue [active] 997761016119 acyl carrier protein; Provisional; Region: PRK07639 997761016120 acyl-CoA synthetase; Validated; Region: PRK08308 997761016121 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 997761016122 acyl-activating enzyme (AAE) consensus motif; other site 997761016123 AMP binding site [chemical binding]; other site 997761016124 active site 997761016125 CoA binding site [chemical binding]; other site 997761016126 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 997761016127 IucA / IucC family; Region: IucA_IucC; pfam04183 997761016128 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 997761016129 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761016130 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 997761016131 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 997761016132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 997761016133 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 997761016134 IucA / IucC family; Region: IucA_IucC; pfam04183 997761016135 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 997761016136 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 997761016137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761016138 catalytic residue [active] 997761016139 diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938 997761016140 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 997761016141 inhibitor-cofactor binding pocket; inhibition site 997761016142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761016143 catalytic residue [active] 997761016144 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 997761016145 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 997761016146 siderophore binding site; other site 997761016147 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 997761016148 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 997761016149 Walker A/P-loop; other site 997761016150 ATP binding site [chemical binding]; other site 997761016151 Q-loop/lid; other site 997761016152 ABC transporter signature motif; other site 997761016153 Walker B; other site 997761016154 D-loop; other site 997761016155 H-loop/switch region; other site 997761016156 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 997761016157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761016158 DNA-binding site [nucleotide binding]; DNA binding site 997761016159 UTRA domain; Region: UTRA; pfam07702 997761016160 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 997761016161 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 997761016162 substrate binding site [chemical binding]; other site 997761016163 ATP binding site [chemical binding]; other site 997761016164 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 997761016165 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 997761016166 putative active site [active] 997761016167 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 997761016168 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 997761016169 fructoselysine 3-epimerase; Provisional; Region: PRK09856 997761016170 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 997761016171 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 997761016172 oligomer interface [polypeptide binding]; other site 997761016173 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 997761016174 Protein of unknown function (DUF458); Region: DUF458; pfam04308 997761016175 NAD-dependent deacetylase; Provisional; Region: PRK00481 997761016176 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 997761016177 NAD+ binding site [chemical binding]; other site 997761016178 substrate binding site [chemical binding]; other site 997761016179 Zn binding site [ion binding]; other site 997761016180 xylose isomerase; Provisional; Region: PRK05474 997761016181 xylose isomerase; Region: xylose_isom_A; TIGR02630 997761016182 DinB superfamily; Region: DinB_2; pfam12867 997761016183 DinB family; Region: DinB; cl17821 997761016184 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 997761016185 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 997761016186 Response regulator receiver domain; Region: Response_reg; pfam00072 997761016187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761016188 active site 997761016189 phosphorylation site [posttranslational modification] 997761016190 intermolecular recognition site; other site 997761016191 dimerization interface [polypeptide binding]; other site 997761016192 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761016193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761016194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761016195 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 997761016196 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761016197 dimerization interface [polypeptide binding]; other site 997761016198 Histidine kinase; Region: His_kinase; pfam06580 997761016199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761016200 ATP binding site [chemical binding]; other site 997761016201 Mg2+ binding site [ion binding]; other site 997761016202 G-X-G motif; other site 997761016203 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761016204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761016205 dimer interface [polypeptide binding]; other site 997761016206 conserved gate region; other site 997761016207 putative PBP binding loops; other site 997761016208 ABC-ATPase subunit interface; other site 997761016209 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 997761016210 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761016211 dimer interface [polypeptide binding]; other site 997761016212 conserved gate region; other site 997761016213 putative PBP binding loops; other site 997761016214 ABC-ATPase subunit interface; other site 997761016215 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761016216 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761016217 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761016218 active site 997761016219 catalytic tetrad [active] 997761016220 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 997761016221 Uncharacterized conserved protein [Function unknown]; Region: COG4715 997761016222 Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682 997761016223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761016224 dimer interface [polypeptide binding]; other site 997761016225 conserved gate region; other site 997761016226 putative PBP binding loops; other site 997761016227 ABC-ATPase subunit interface; other site 997761016228 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 997761016229 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761016230 substrate binding pocket [chemical binding]; other site 997761016231 membrane-bound complex binding site; other site 997761016232 hinge residues; other site 997761016233 Nuclease-related domain; Region: NERD; pfam08378 997761016234 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 997761016235 ATP binding site [chemical binding]; other site 997761016236 putative Mg++ binding site [ion binding]; other site 997761016237 Family description; Region: UvrD_C_2; pfam13538 997761016238 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 997761016239 active site 997761016240 NTP binding site [chemical binding]; other site 997761016241 metal binding triad [ion binding]; metal-binding site 997761016242 antibiotic binding site [chemical binding]; other site 997761016243 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 997761016244 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 997761016245 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 997761016246 Nuclease-related domain; Region: NERD; pfam08378 997761016247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761016248 Walker A motif; other site 997761016249 ATP binding site [chemical binding]; other site 997761016250 Walker B motif; other site 997761016251 arginine finger; other site 997761016252 DnaA N-terminal domain; Region: DnaA_N; pfam11638 997761016253 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 997761016254 Peptidases of the G1 family and homologs that might lack peptidase activity; Region: Peptidase_G1_like; cl03371 997761016255 BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473 997761016256 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761016257 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761016258 dimer interface [polypeptide binding]; other site 997761016259 phosphorylation site [posttranslational modification] 997761016260 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761016261 ATP binding site [chemical binding]; other site 997761016262 Mg2+ binding site [ion binding]; other site 997761016263 G-X-G motif; other site 997761016264 Response regulator receiver domain; Region: Response_reg; pfam00072 997761016265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761016266 active site 997761016267 phosphorylation site [posttranslational modification] 997761016268 intermolecular recognition site; other site 997761016269 dimerization interface [polypeptide binding]; other site 997761016270 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 997761016271 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 997761016272 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 997761016273 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 997761016274 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 997761016275 A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449 997761016276 Proteins of 100 residues with WXG; Region: WXG100; cl02005 997761016277 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 997761016278 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 997761016279 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 997761016280 DNA interaction; other site 997761016281 Metal-binding active site; metal-binding site 997761016282 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 997761016283 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 997761016284 active site 997761016285 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 997761016286 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 997761016287 putative metal binding site; other site 997761016288 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 997761016289 active site 997761016290 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 997761016291 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 997761016292 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 997761016293 TROVE domain; Region: TROVE; pfam05731 997761016294 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 997761016295 metal ion-dependent adhesion site (MIDAS); other site 997761016296 WYL domain; Region: WYL; pfam13280 997761016297 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 997761016298 oligomerisation interface [polypeptide binding]; other site 997761016299 mobile loop; other site 997761016300 roof hairpin; other site 997761016301 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 997761016302 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 997761016303 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 997761016304 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761016305 dimer interface [polypeptide binding]; other site 997761016306 conserved gate region; other site 997761016307 putative PBP binding loops; other site 997761016308 ABC-ATPase subunit interface; other site 997761016309 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 997761016310 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761016311 dimer interface [polypeptide binding]; other site 997761016312 conserved gate region; other site 997761016313 putative PBP binding loops; other site 997761016314 ABC-ATPase subunit interface; other site 997761016315 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 997761016316 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761016317 Walker A/P-loop; other site 997761016318 ATP binding site [chemical binding]; other site 997761016319 Q-loop/lid; other site 997761016320 ABC transporter signature motif; other site 997761016321 Walker B; other site 997761016322 D-loop; other site 997761016323 H-loop/switch region; other site 997761016324 TOBE domain; Region: TOBE_2; pfam08402 997761016325 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761016326 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 997761016327 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 997761016328 Walker A/P-loop; other site 997761016329 ATP binding site [chemical binding]; other site 997761016330 Q-loop/lid; other site 997761016331 ABC transporter signature motif; other site 997761016332 Walker B; other site 997761016333 D-loop; other site 997761016334 H-loop/switch region; other site 997761016335 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 997761016336 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761016337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761016338 Walker A/P-loop; other site 997761016339 ATP binding site [chemical binding]; other site 997761016340 Q-loop/lid; other site 997761016341 ABC transporter signature motif; other site 997761016342 Walker B; other site 997761016343 D-loop; other site 997761016344 H-loop/switch region; other site 997761016345 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 997761016346 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 997761016347 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 997761016348 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 997761016349 active site 997761016350 dimer interface [polypeptide binding]; other site 997761016351 motif 1; other site 997761016352 motif 2; other site 997761016353 motif 3; other site 997761016354 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 997761016355 anticodon binding site; other site 997761016356 amidase; Provisional; Region: PRK06828 997761016357 Amidase; Region: Amidase; cl11426 997761016358 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 997761016359 TraX protein; Region: TraX; cl05434 997761016360 cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847 997761016361 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 997761016362 Subunit I/III interface [polypeptide binding]; other site 997761016363 Subunit III/IV interface [polypeptide binding]; other site 997761016364 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 997761016365 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 997761016366 D-pathway; other site 997761016367 Putative ubiquinol binding site [chemical binding]; other site 997761016368 Low-spin heme (heme b) binding site [chemical binding]; other site 997761016369 Putative water exit pathway; other site 997761016370 Binuclear center (heme o3/CuB) [ion binding]; other site 997761016371 K-pathway; other site 997761016372 Putative proton exit pathway; other site 997761016373 cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433 997761016374 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 997761016375 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 997761016376 putative pectinesterase; Region: PLN02432; cl01911 997761016377 Pectinesterase; Region: Pectinesterase; pfam01095 997761016378 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 997761016379 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 997761016380 catalytic residues [active] 997761016381 dimer interface [polypeptide binding]; other site 997761016382 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 997761016383 rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637 997761016384 ligand binding site [chemical binding]; other site 997761016385 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 997761016386 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761016387 TM-ABC transporter signature motif; other site 997761016388 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 997761016389 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 997761016390 TM-ABC transporter signature motif; other site 997761016391 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 997761016392 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 997761016393 Walker A/P-loop; other site 997761016394 ATP binding site [chemical binding]; other site 997761016395 Q-loop/lid; other site 997761016396 ABC transporter signature motif; other site 997761016397 Walker B; other site 997761016398 D-loop; other site 997761016399 H-loop/switch region; other site 997761016400 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 997761016401 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 997761016402 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 997761016403 Walker A/P-loop; other site 997761016404 ATP binding site [chemical binding]; other site 997761016405 Q-loop/lid; other site 997761016406 ABC transporter signature motif; other site 997761016407 Walker B; other site 997761016408 D-loop; other site 997761016409 H-loop/switch region; other site 997761016410 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 997761016411 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 997761016412 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 997761016413 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 997761016414 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 997761016415 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 997761016416 DNA binding residues [nucleotide binding] 997761016417 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 997761016418 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 997761016419 DNA binding residues [nucleotide binding] 997761016420 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 997761016421 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 997761016422 Cache domain; Region: Cache_1; pfam02743 997761016423 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761016424 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761016425 metal binding site [ion binding]; metal-binding site 997761016426 active site 997761016427 I-site; other site 997761016428 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 997761016429 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 997761016430 putative metal binding site [ion binding]; other site 997761016431 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 997761016432 active site 997761016433 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761016434 sequence-specific DNA binding site [nucleotide binding]; other site 997761016435 salt bridge; other site 997761016436 Cupin domain; Region: Cupin_2; pfam07883 997761016437 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761016438 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761016439 dimer interface [polypeptide binding]; other site 997761016440 phosphorylation site [posttranslational modification] 997761016441 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761016442 ATP binding site [chemical binding]; other site 997761016443 Mg2+ binding site [ion binding]; other site 997761016444 G-X-G motif; other site 997761016445 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761016446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761016447 active site 997761016448 phosphorylation site [posttranslational modification] 997761016449 intermolecular recognition site; other site 997761016450 dimerization interface [polypeptide binding]; other site 997761016451 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761016452 DNA binding site [nucleotide binding] 997761016453 Predicted membrane protein [Function unknown]; Region: COG2311 997761016454 Protein of unknown function (DUF418); Region: DUF418; cl12135 997761016455 Protein of unknown function (DUF418); Region: DUF418; pfam04235 997761016456 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761016457 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 997761016458 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761016459 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761016460 dimer interface [polypeptide binding]; other site 997761016461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761016462 ATP binding site [chemical binding]; other site 997761016463 Mg2+ binding site [ion binding]; other site 997761016464 G-X-G motif; other site 997761016465 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 997761016466 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 997761016467 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 997761016468 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 997761016469 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 997761016470 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 997761016471 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 997761016472 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 997761016473 Walker A motif; other site 997761016474 ATP binding site [chemical binding]; other site 997761016475 Walker B motif; other site 997761016476 NAD-dependent deacetylase; Provisional; Region: PRK00481 997761016477 SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407 997761016478 NAD+ binding site [chemical binding]; other site 997761016479 substrate binding site [chemical binding]; other site 997761016480 Zn binding site [ion binding]; other site 997761016481 pullulanase, type I; Region: pulA_typeI; TIGR02104 997761016482 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 997761016483 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 997761016484 Ca binding site [ion binding]; other site 997761016485 active site 997761016486 catalytic site [active] 997761016487 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 997761016488 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 997761016489 tetramer interface [polypeptide binding]; other site 997761016490 heme binding pocket [chemical binding]; other site 997761016491 NADPH binding site [chemical binding]; other site 997761016492 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761016493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761016494 active site 997761016495 phosphorylation site [posttranslational modification] 997761016496 intermolecular recognition site; other site 997761016497 dimerization interface [polypeptide binding]; other site 997761016498 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 997761016499 DNA binding residues [nucleotide binding] 997761016500 dimerization interface [polypeptide binding]; other site 997761016501 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 997761016502 TspO/MBR family; Region: TspO_MBR; cl01379 997761016503 Histidine kinase; Region: HisKA_3; pfam07730 997761016504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761016505 ATP binding site [chemical binding]; other site 997761016506 Mg2+ binding site [ion binding]; other site 997761016507 G-X-G motif; other site 997761016508 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 997761016509 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 997761016510 putative di-iron ligands [ion binding]; other site 997761016511 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 997761016512 active site 997761016513 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 997761016514 active site 997761016515 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 997761016516 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 997761016517 putative sugar binding sites [chemical binding]; other site 997761016518 Q-X-W motif; other site 997761016519 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 997761016520 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 997761016521 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 997761016522 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 997761016523 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 997761016524 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 997761016525 Sel1-like repeats; Region: SEL1; smart00671 997761016526 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 997761016527 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 997761016528 Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400 997761016529 putative active site [active] 997761016530 putative metal binding site [ion binding]; other site 997761016531 HEAT repeats; Region: HEAT_2; pfam13646 997761016532 HEAT repeats; Region: HEAT_2; pfam13646 997761016533 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 997761016534 nudix motif; other site 997761016535 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 997761016536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761016537 S-adenosylmethionine binding site [chemical binding]; other site 997761016538 putative lipid kinase; Reviewed; Region: PRK13337 997761016539 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 997761016540 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 997761016541 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 997761016542 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 997761016543 active site 997761016544 FMN binding site [chemical binding]; other site 997761016545 substrate binding site [chemical binding]; other site 997761016546 homotetramer interface [polypeptide binding]; other site 997761016547 catalytic residue [active] 997761016548 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 997761016549 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761016550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761016551 dimer interface [polypeptide binding]; other site 997761016552 phosphorylation site [posttranslational modification] 997761016553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761016554 ATP binding site [chemical binding]; other site 997761016555 Mg2+ binding site [ion binding]; other site 997761016556 G-X-G motif; other site 997761016557 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 997761016558 conserved cys residue [active] 997761016559 Cupin domain; Region: Cupin_2; pfam07883 997761016560 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761016561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761016562 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 997761016563 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761016564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761016565 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761016566 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761016567 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761016568 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761016569 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 997761016570 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761016571 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761016572 DNA binding residues [nucleotide binding] 997761016573 Predicted membrane protein [Function unknown]; Region: COG2261 997761016574 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761016575 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761016576 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 997761016577 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761016578 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761016579 metal binding site [ion binding]; metal-binding site 997761016580 active site 997761016581 I-site; other site 997761016582 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 997761016583 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 997761016584 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761016585 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 997761016586 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761016587 DNA binding residues [nucleotide binding] 997761016588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 997761016589 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 997761016590 ATP binding site [chemical binding]; other site 997761016591 G-X-G motif; other site 997761016592 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 997761016593 anti sigma factor interaction site; other site 997761016594 regulatory phosphorylation site [posttranslational modification]; other site 997761016595 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 997761016596 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 997761016597 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 997761016598 dimerization interface [polypeptide binding]; other site 997761016599 DPS ferroxidase diiron center [ion binding]; other site 997761016600 ion pore; other site 997761016601 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 997761016602 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 997761016603 ligand binding site [chemical binding]; other site 997761016604 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 997761016605 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 997761016606 Walker A/P-loop; other site 997761016607 ATP binding site [chemical binding]; other site 997761016608 Q-loop/lid; other site 997761016609 ABC transporter signature motif; other site 997761016610 Walker B; other site 997761016611 D-loop; other site 997761016612 H-loop/switch region; other site 997761016613 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 997761016614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 997761016615 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 997761016616 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 997761016617 anti sigma factor interaction site; other site 997761016618 regulatory phosphorylation site [posttranslational modification]; other site 997761016619 Heat induced stress protein YflT; Region: YflT; pfam11181 997761016620 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 997761016621 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 997761016622 ligand binding site; other site 997761016623 oligomer interface; other site 997761016624 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 997761016625 N-terminal domain interface [polypeptide binding]; other site 997761016626 sulfate 1 binding site; other site 997761016627 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761016628 Interdomain contacts; other site 997761016629 Cytokine receptor motif; other site 997761016630 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761016631 Interdomain contacts; other site 997761016632 Cytokine receptor motif; other site 997761016633 Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547 997761016634 dockerin binding interface; other site 997761016635 Response regulator receiver domain; Region: Response_reg; pfam00072 997761016636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761016637 active site 997761016638 phosphorylation site [posttranslational modification] 997761016639 intermolecular recognition site; other site 997761016640 dimerization interface [polypeptide binding]; other site 997761016641 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761016642 dimer interface [polypeptide binding]; other site 997761016643 phosphorylation site [posttranslational modification] 997761016644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761016645 ATP binding site [chemical binding]; other site 997761016646 Mg2+ binding site [ion binding]; other site 997761016647 G-X-G motif; other site 997761016648 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 997761016649 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 997761016650 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 997761016651 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 997761016652 dimerization interface [polypeptide binding]; other site 997761016653 GAF domain; Region: GAF_3; pfam13492 997761016654 GAF domain; Region: GAF_2; pfam13185 997761016655 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761016656 dimer interface [polypeptide binding]; other site 997761016657 phosphorylation site [posttranslational modification] 997761016658 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761016659 ATP binding site [chemical binding]; other site 997761016660 Mg2+ binding site [ion binding]; other site 997761016661 G-X-G motif; other site 997761016662 Response regulator receiver domain; Region: Response_reg; pfam00072 997761016663 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761016664 active site 997761016665 phosphorylation site [posttranslational modification] 997761016666 intermolecular recognition site; other site 997761016667 dimerization interface [polypeptide binding]; other site 997761016668 Response regulator receiver domain; Region: Response_reg; pfam00072 997761016669 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761016670 active site 997761016671 phosphorylation site [posttranslational modification] 997761016672 intermolecular recognition site; other site 997761016673 dimerization interface [polypeptide binding]; other site 997761016674 Response regulator receiver domain; Region: Response_reg; pfam00072 997761016675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761016676 active site 997761016677 phosphorylation site [posttranslational modification] 997761016678 intermolecular recognition site; other site 997761016679 dimerization interface [polypeptide binding]; other site 997761016680 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761016681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761016682 active site 997761016683 phosphorylation site [posttranslational modification] 997761016684 intermolecular recognition site; other site 997761016685 dimerization interface [polypeptide binding]; other site 997761016686 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 997761016687 Heat induced stress protein YflT; Region: YflT; pfam11181 997761016688 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 997761016689 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 997761016690 NodB motif; other site 997761016691 active site 997761016692 catalytic site [active] 997761016693 metal binding site [ion binding]; metal-binding site 997761016694 RNA polymerase factor sigma C; Reviewed; Region: PRK09415 997761016695 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761016696 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761016697 DNA binding residues [nucleotide binding] 997761016698 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 997761016699 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 997761016700 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 997761016701 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 997761016702 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 997761016703 putative active site [active] 997761016704 metal binding site [ion binding]; metal-binding site 997761016705 DinB superfamily; Region: DinB_2; pfam12867 997761016706 Predicted transcriptional regulator [Transcription]; Region: COG2378 997761016707 HTH domain; Region: HTH_11; pfam08279 997761016708 WYL domain; Region: WYL; pfam13280 997761016709 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 997761016710 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 997761016711 catalytic residues [active] 997761016712 IDEAL domain; Region: IDEAL; cl07452 997761016713 Predicted transcriptional regulator [Transcription]; Region: COG1959 997761016714 Transcriptional regulator; Region: Rrf2; pfam02082 997761016715 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 997761016716 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 997761016717 siderophore binding site; other site 997761016718 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 997761016719 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761016720 ABC-ATPase subunit interface; other site 997761016721 dimer interface [polypeptide binding]; other site 997761016722 putative PBP binding regions; other site 997761016723 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 997761016724 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761016725 ABC-ATPase subunit interface; other site 997761016726 dimer interface [polypeptide binding]; other site 997761016727 putative PBP binding regions; other site 997761016728 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 997761016729 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 997761016730 Walker A/P-loop; other site 997761016731 ATP binding site [chemical binding]; other site 997761016732 Q-loop/lid; other site 997761016733 ABC transporter signature motif; other site 997761016734 Walker B; other site 997761016735 D-loop; other site 997761016736 H-loop/switch region; other site 997761016737 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 997761016738 glycosyltransferase, MGT family; Region: MGT; TIGR01426 997761016739 active site 997761016740 TDP-binding site; other site 997761016741 acceptor substrate-binding pocket; other site 997761016742 homodimer interface [polypeptide binding]; other site 997761016743 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 997761016744 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 997761016745 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 997761016746 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 997761016747 IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330 997761016748 5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106 997761016749 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 997761016750 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 997761016751 active site 997761016752 substrate binding site [chemical binding]; other site 997761016753 cosubstrate binding site; other site 997761016754 catalytic site [active] 997761016755 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 997761016756 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 997761016757 dimerization interface [polypeptide binding]; other site 997761016758 putative ATP binding site [chemical binding]; other site 997761016759 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 997761016760 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 997761016761 active site 997761016762 tetramer interface [polypeptide binding]; other site 997761016763 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 997761016764 active site 997761016765 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 997761016766 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 997761016767 dimerization interface [polypeptide binding]; other site 997761016768 ATP binding site [chemical binding]; other site 997761016769 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 997761016770 dimerization interface [polypeptide binding]; other site 997761016771 ATP binding site [chemical binding]; other site 997761016772 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 997761016773 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 997761016774 putative active site [active] 997761016775 catalytic triad [active] 997761016776 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 997761016777 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 997761016778 ATP binding site [chemical binding]; other site 997761016779 active site 997761016780 substrate binding site [chemical binding]; other site 997761016781 adenylosuccinate lyase; Provisional; Region: PRK07492 997761016782 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 997761016783 tetramer interface [polypeptide binding]; other site 997761016784 active site 997761016785 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 997761016786 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761016787 3D domain; Region: 3D; cl01439 997761016788 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 997761016789 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 997761016790 NodB motif; other site 997761016791 active site 997761016792 catalytic site [active] 997761016793 metal binding site [ion binding]; metal-binding site 997761016794 Protein of unknown function (DUF2512); Region: DUF2512; pfam10710 997761016795 UGMP family protein; Validated; Region: PRK09604 997761016796 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 997761016797 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 997761016798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761016799 Coenzyme A binding pocket [chemical binding]; other site 997761016800 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 997761016801 Glycoprotease family; Region: Peptidase_M22; pfam00814 997761016802 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 997761016803 thiamine monophosphate kinase; Provisional; Region: PRK05731 997761016804 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 997761016805 ATP binding site [chemical binding]; other site 997761016806 dimerization interface [polypeptide binding]; other site 997761016807 Small acid-soluble spore protein H family; Region: SspH; cl06949 997761016808 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 997761016809 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 997761016810 putative DNA binding site [nucleotide binding]; other site 997761016811 putative homodimer interface [polypeptide binding]; other site 997761016812 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 997761016813 TrkA-C domain; Region: TrkA_C; pfam02080 997761016814 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 997761016815 nucleotide binding site [chemical binding]; other site 997761016816 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 997761016817 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 997761016818 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 997761016819 putative active site [active] 997761016820 catalytic site [active] 997761016821 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 997761016822 putative active site [active] 997761016823 catalytic site [active] 997761016824 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 997761016825 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 997761016826 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 997761016827 Spore germination protein; Region: Spore_permease; cl17796 997761016828 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 997761016829 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 997761016830 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 997761016831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761016832 motif II; other site 997761016833 aminoglycoside resistance protein; Provisional; Region: PRK13746 997761016834 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 997761016835 metal binding triad [ion binding]; metal-binding site 997761016836 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 997761016837 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 997761016838 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 997761016839 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 997761016840 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 997761016841 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 997761016842 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 997761016843 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 997761016844 active site 997761016845 dimer interface [polypeptide binding]; other site 997761016846 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 997761016847 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 997761016848 active site 997761016849 FMN binding site [chemical binding]; other site 997761016850 substrate binding site [chemical binding]; other site 997761016851 3Fe-4S cluster binding site [ion binding]; other site 997761016852 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 997761016853 domain interface; other site 997761016854 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761016855 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 997761016856 putative active site [active] 997761016857 heme pocket [chemical binding]; other site 997761016858 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761016859 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 997761016860 putative active site [active] 997761016861 heme pocket [chemical binding]; other site 997761016862 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761016863 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 997761016864 putative active site [active] 997761016865 heme pocket [chemical binding]; other site 997761016866 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761016867 phosphorylation site [posttranslational modification] 997761016868 dimer interface [polypeptide binding]; other site 997761016869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761016870 ATP binding site [chemical binding]; other site 997761016871 Mg2+ binding site [ion binding]; other site 997761016872 G-X-G motif; other site 997761016873 thymidine kinase; Provisional; Region: PRK04296 997761016874 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 997761016875 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761016876 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761016877 homodimer interface [polypeptide binding]; other site 997761016878 catalytic residue [active] 997761016879 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 997761016880 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 997761016881 DNA-binding site [nucleotide binding]; DNA binding site 997761016882 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 997761016883 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761016884 homodimer interface [polypeptide binding]; other site 997761016885 catalytic residue [active] 997761016886 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 997761016887 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761016888 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761016889 DNA binding residues [nucleotide binding] 997761016890 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 997761016891 putative homodimer interface [polypeptide binding]; other site 997761016892 putative homotetramer interface [polypeptide binding]; other site 997761016893 allosteric switch controlling residues; other site 997761016894 putative metal binding site [ion binding]; other site 997761016895 putative homodimer-homodimer interface [polypeptide binding]; other site 997761016896 Uncharacterized conserved protein [Function unknown]; Region: COG3349 997761016897 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 997761016898 intracellular protease, PfpI family; Region: PfpI; TIGR01382 997761016899 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 997761016900 proposed catalytic triad [active] 997761016901 conserved cys residue [active] 997761016902 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 997761016903 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 997761016904 Ca binding site [ion binding]; other site 997761016905 active site 997761016906 catalytic site [active] 997761016907 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 997761016908 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 997761016909 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 997761016910 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761016911 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761016912 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 997761016913 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 997761016914 putative ADP-ribose binding site [chemical binding]; other site 997761016915 putative active site [active] 997761016916 Response regulator receiver domain; Region: Response_reg; pfam00072 997761016917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761016918 active site 997761016919 phosphorylation site [posttranslational modification] 997761016920 intermolecular recognition site; other site 997761016921 dimerization interface [polypeptide binding]; other site 997761016922 Coat F domain; Region: Coat_F; pfam07875 997761016923 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761016924 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761016925 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 997761016926 CheW-like domain; Region: CheW; pfam01584 997761016927 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 997761016928 lipoyl attachment site [posttranslational modification]; other site 997761016929 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 997761016930 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 997761016931 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 997761016932 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 997761016933 tetramer interface [polypeptide binding]; other site 997761016934 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761016935 catalytic residue [active] 997761016936 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 997761016937 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811 997761016938 Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042 997761016939 Lamin Tail Domain; Region: LTD; pfam00932 997761016940 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 997761016941 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761016942 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761016943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761016944 Transcriptional regulators [Transcription]; Region: PurR; COG1609 997761016945 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 997761016946 DNA binding site [nucleotide binding] 997761016947 domain linker motif; other site 997761016948 Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286 997761016949 putative dimerization interface [polypeptide binding]; other site 997761016950 putative ligand binding site [chemical binding]; other site 997761016951 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 997761016952 Glyco_18 domain; Region: Glyco_18; smart00636 997761016953 active site 997761016954 S-layer homology domain; Region: SLH; pfam00395 997761016955 S-layer homology domain; Region: SLH; pfam00395 997761016956 S-layer homology domain; Region: SLH; pfam00395 997761016957 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 997761016958 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 997761016959 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 997761016960 oligomer interface [polypeptide binding]; other site 997761016961 metal binding site [ion binding]; metal-binding site 997761016962 metal binding site [ion binding]; metal-binding site 997761016963 putative Cl binding site [ion binding]; other site 997761016964 aspartate ring; other site 997761016965 basic sphincter; other site 997761016966 hydrophobic gate; other site 997761016967 periplasmic entrance; other site 997761016968 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 997761016969 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 997761016970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761016971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761016972 Predicted membrane protein [Function unknown]; Region: COG3326 997761016973 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 997761016974 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761016975 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761016976 metal binding site [ion binding]; metal-binding site 997761016977 active site 997761016978 I-site; other site 997761016979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761016980 dimer interface [polypeptide binding]; other site 997761016981 phosphorylation site [posttranslational modification] 997761016982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761016983 ATP binding site [chemical binding]; other site 997761016984 Mg2+ binding site [ion binding]; other site 997761016985 G-X-G motif; other site 997761016986 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761016987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761016988 active site 997761016989 phosphorylation site [posttranslational modification] 997761016990 intermolecular recognition site; other site 997761016991 dimerization interface [polypeptide binding]; other site 997761016992 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761016993 DNA binding site [nucleotide binding] 997761016994 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 997761016995 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761016996 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761016997 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761016998 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761016999 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 997761017000 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761017001 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761017002 dimer interface [polypeptide binding]; other site 997761017003 conserved gate region; other site 997761017004 putative PBP binding loops; other site 997761017005 ABC-ATPase subunit interface; other site 997761017006 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761017007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761017008 dimer interface [polypeptide binding]; other site 997761017009 conserved gate region; other site 997761017010 ABC-ATPase subunit interface; other site 997761017011 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 997761017012 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 997761017013 NAD(P) binding site [chemical binding]; other site 997761017014 catalytic residues [active] 997761017015 4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918 997761017016 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 997761017017 inhibitor-cofactor binding pocket; inhibition site 997761017018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761017019 catalytic residue [active] 997761017020 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 997761017021 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 997761017022 inhibitor-cofactor binding pocket; inhibition site 997761017023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761017024 catalytic residue [active] 997761017025 Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119 997761017026 glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804 997761017027 tetramerization interface [polypeptide binding]; other site 997761017028 NAD(P) binding site [chemical binding]; other site 997761017029 catalytic residues [active] 997761017030 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 997761017031 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 997761017032 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 997761017033 NAD(P) binding site [chemical binding]; other site 997761017034 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 997761017035 tetramer interface [polypeptide binding]; other site 997761017036 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 997761017037 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 997761017038 active site 997761017039 multimer interface [polypeptide binding]; other site 997761017040 Protein of unknown function (DUF441); Region: DUF441; pfam04284 997761017041 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761017042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761017043 ATP binding site [chemical binding]; other site 997761017044 Mg2+ binding site [ion binding]; other site 997761017045 G-X-G motif; other site 997761017046 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 997761017047 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761017048 active site 997761017049 phosphorylation site [posttranslational modification] 997761017050 intermolecular recognition site; other site 997761017051 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 997761017052 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 997761017053 carboxyltransferase (CT) interaction site; other site 997761017054 biotinylation site [posttranslational modification]; other site 997761017055 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 997761017056 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 997761017057 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761017058 putative active site [active] 997761017059 heme pocket [chemical binding]; other site 997761017060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761017061 Walker A motif; other site 997761017062 ATP binding site [chemical binding]; other site 997761017063 Walker B motif; other site 997761017064 arginine finger; other site 997761017065 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 997761017066 agmatinase; Region: agmatinase; TIGR01230 997761017067 oligomer interface [polypeptide binding]; other site 997761017068 putative active site [active] 997761017069 Mn binding site [ion binding]; other site 997761017070 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 997761017071 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 997761017072 HIGH motif; other site 997761017073 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 997761017074 active site 997761017075 KMSKS motif; other site 997761017076 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 997761017077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761017078 ATP binding site [chemical binding]; other site 997761017079 Mg2+ binding site [ion binding]; other site 997761017080 G-X-G motif; other site 997761017081 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 997761017082 Amidinotransferase; Region: Amidinotransf; pfam02274 997761017083 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 997761017084 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 997761017085 active site 997761017086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 997761017087 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 997761017088 catalytic core [active] 997761017089 EamA-like transporter family; Region: EamA; pfam00892 997761017090 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 997761017091 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 997761017092 glutaminase active site [active] 997761017093 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 997761017094 dimer interface [polypeptide binding]; other site 997761017095 active site 997761017096 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 997761017097 dimer interface [polypeptide binding]; other site 997761017098 active site 997761017099 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 997761017100 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 997761017101 active site 997761017102 substrate binding site [chemical binding]; other site 997761017103 metal binding site [ion binding]; metal-binding site 997761017104 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 997761017105 YbbR-like protein; Region: YbbR; pfam07949 997761017106 Uncharacterized conserved protein [Function unknown]; Region: COG1624 997761017107 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 997761017108 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 997761017109 Putative zinc-finger; Region: zf-HC2; pfam13490 997761017110 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 997761017111 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 997761017112 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761017113 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 997761017114 DNA binding residues [nucleotide binding] 997761017115 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 997761017116 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 997761017117 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 997761017118 homodimer interface [polypeptide binding]; other site 997761017119 maltodextrin glucosidase; Provisional; Region: PRK10785 997761017120 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 997761017121 active site 997761017122 homodimer interface [polypeptide binding]; other site 997761017123 catalytic site [active] 997761017124 Heat induced stress protein YflT; Region: YflT; pfam11181 997761017125 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 997761017126 Domain of unknown function DUF20; Region: UPF0118; pfam01594 997761017127 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 997761017128 classical (c) SDRs; Region: SDR_c; cd05233 997761017129 NAD(P) binding site [chemical binding]; other site 997761017130 active site 997761017131 Integral membrane protein DUF95; Region: DUF95; pfam01944 997761017132 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 997761017133 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 997761017134 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 997761017135 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 997761017136 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 997761017137 Walker A motif; other site 997761017138 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 997761017139 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 997761017140 active site 997761017141 metal binding site [ion binding]; metal-binding site 997761017142 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 997761017143 ATP-sulfurylase; Region: ATPS; cd00517 997761017144 active site 997761017145 HXXH motif; other site 997761017146 flexible loop; other site 997761017147 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 997761017148 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 997761017149 Active Sites [active] 997761017150 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 997761017151 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 997761017152 23S rRNA interface [nucleotide binding]; other site 997761017153 L3 interface [polypeptide binding]; other site 997761017154 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 997761017155 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 997761017156 dimerization interface 3.5A [polypeptide binding]; other site 997761017157 active site 997761017158 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 997761017159 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 997761017160 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 997761017161 alphaNTD - beta interaction site [polypeptide binding]; other site 997761017162 alphaNTD homodimer interface [polypeptide binding]; other site 997761017163 alphaNTD - beta' interaction site [polypeptide binding]; other site 997761017164 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 997761017165 30S ribosomal protein S11; Validated; Region: PRK05309 997761017166 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 997761017167 30S ribosomal protein S13; Region: bact_S13; TIGR03631 997761017168 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 997761017169 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 997761017170 RNA binding site [nucleotide binding]; other site 997761017171 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 997761017172 active site 997761017173 adenylate kinase; Reviewed; Region: adk; PRK00279 997761017174 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 997761017175 AMP-binding site [chemical binding]; other site 997761017176 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 997761017177 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 997761017178 SecY translocase; Region: SecY; pfam00344 997761017179 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 997761017180 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 997761017181 23S rRNA binding site [nucleotide binding]; other site 997761017182 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 997761017183 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 997761017184 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 997761017185 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 997761017186 5S rRNA interface [nucleotide binding]; other site 997761017187 L27 interface [polypeptide binding]; other site 997761017188 23S rRNA interface [nucleotide binding]; other site 997761017189 L5 interface [polypeptide binding]; other site 997761017190 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 997761017191 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 997761017192 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 997761017193 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 997761017194 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 997761017195 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 997761017196 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 997761017197 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 997761017198 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 997761017199 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 997761017200 RNA binding site [nucleotide binding]; other site 997761017201 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 997761017202 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 997761017203 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 997761017204 23S rRNA interface [nucleotide binding]; other site 997761017205 putative translocon interaction site; other site 997761017206 signal recognition particle (SRP54) interaction site; other site 997761017207 L23 interface [polypeptide binding]; other site 997761017208 trigger factor interaction site; other site 997761017209 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 997761017210 23S rRNA interface [nucleotide binding]; other site 997761017211 5S rRNA interface [nucleotide binding]; other site 997761017212 putative antibiotic binding site [chemical binding]; other site 997761017213 L25 interface [polypeptide binding]; other site 997761017214 L27 interface [polypeptide binding]; other site 997761017215 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 997761017216 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 997761017217 G-X-X-G motif; other site 997761017218 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 997761017219 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 997761017220 putative translocon binding site; other site 997761017221 protein-rRNA interface [nucleotide binding]; other site 997761017222 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 997761017223 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 997761017224 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 997761017225 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 997761017226 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 997761017227 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 997761017228 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 997761017229 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 997761017230 elongation factor Tu; Reviewed; Region: PRK00049 997761017231 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 997761017232 G1 box; other site 997761017233 GEF interaction site [polypeptide binding]; other site 997761017234 GTP/Mg2+ binding site [chemical binding]; other site 997761017235 Switch I region; other site 997761017236 G2 box; other site 997761017237 G3 box; other site 997761017238 Switch II region; other site 997761017239 G4 box; other site 997761017240 G5 box; other site 997761017241 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 997761017242 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 997761017243 Antibiotic Binding Site [chemical binding]; other site 997761017244 30S ribosomal protein S7; Validated; Region: PRK05302 997761017245 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 997761017246 S17 interaction site [polypeptide binding]; other site 997761017247 S8 interaction site; other site 997761017248 16S rRNA interaction site [nucleotide binding]; other site 997761017249 streptomycin interaction site [chemical binding]; other site 997761017250 23S rRNA interaction site [nucleotide binding]; other site 997761017251 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 997761017252 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 997761017253 DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085 997761017254 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 997761017255 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 997761017256 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 997761017257 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 997761017258 RPB10 interaction site [polypeptide binding]; other site 997761017259 RPB1 interaction site [polypeptide binding]; other site 997761017260 RPB11 interaction site [polypeptide binding]; other site 997761017261 RPB3 interaction site [polypeptide binding]; other site 997761017262 RPB12 interaction site [polypeptide binding]; other site 997761017263 Methyltransferase domain; Region: Methyltransf_31; pfam13847 997761017264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761017265 S-adenosylmethionine binding site [chemical binding]; other site 997761017266 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 997761017267 core dimer interface [polypeptide binding]; other site 997761017268 peripheral dimer interface [polypeptide binding]; other site 997761017269 L10 interface [polypeptide binding]; other site 997761017270 L11 interface [polypeptide binding]; other site 997761017271 putative EF-Tu interaction site [polypeptide binding]; other site 997761017272 putative EF-G interaction site [polypeptide binding]; other site 997761017273 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 997761017274 23S rRNA interface [nucleotide binding]; other site 997761017275 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 997761017276 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 997761017277 mRNA/rRNA interface [nucleotide binding]; other site 997761017278 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 997761017279 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 997761017280 23S rRNA interface [nucleotide binding]; other site 997761017281 L7/L12 interface [polypeptide binding]; other site 997761017282 putative thiostrepton binding site; other site 997761017283 L25 interface [polypeptide binding]; other site 997761017284 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 997761017285 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 997761017286 putative homodimer interface [polypeptide binding]; other site 997761017287 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 997761017288 heterodimer interface [polypeptide binding]; other site 997761017289 homodimer interface [polypeptide binding]; other site 997761017290 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 997761017291 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 997761017292 RNA polymerase factor sigma-70; Validated; Region: PRK08295 997761017293 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 997761017294 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 997761017295 YacP-like NYN domain; Region: NYN_YacP; pfam05991 997761017296 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 997761017297 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 997761017298 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 997761017299 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 997761017300 dimerization interface [polypeptide binding]; other site 997761017301 active site 997761017302 metal binding site [ion binding]; metal-binding site 997761017303 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 997761017304 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 997761017305 active site 997761017306 HIGH motif; other site 997761017307 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 997761017308 KMSKS motif; other site 997761017309 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 997761017310 tRNA binding surface [nucleotide binding]; other site 997761017311 anticodon binding site; other site 997761017312 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 997761017313 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 997761017314 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 997761017315 trimer interface [polypeptide binding]; other site 997761017316 active site 997761017317 substrate binding site [chemical binding]; other site 997761017318 CoA binding site [chemical binding]; other site 997761017319 Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565 997761017320 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 997761017321 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 997761017322 active site 997761017323 HIGH motif; other site 997761017324 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 997761017325 active site 997761017326 KMSKS motif; other site 997761017327 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 997761017328 homotrimer interaction site [polypeptide binding]; other site 997761017329 zinc binding site [ion binding]; other site 997761017330 CDP-binding sites; other site 997761017331 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 997761017332 substrate binding site; other site 997761017333 dimer interface; other site 997761017334 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 997761017335 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 997761017336 putative active site [active] 997761017337 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 997761017338 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 997761017339 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 997761017340 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 997761017341 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 997761017342 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 997761017343 Clp amino terminal domain; Region: Clp_N; pfam02861 997761017344 Clp amino terminal domain; Region: Clp_N; pfam02861 997761017345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761017346 Walker A motif; other site 997761017347 ATP binding site [chemical binding]; other site 997761017348 Walker B motif; other site 997761017349 arginine finger; other site 997761017350 UvrB/uvrC motif; Region: UVR; pfam02151 997761017351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761017352 Walker A motif; other site 997761017353 ATP binding site [chemical binding]; other site 997761017354 Walker B motif; other site 997761017355 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 997761017356 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 997761017357 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 997761017358 ADP binding site [chemical binding]; other site 997761017359 phosphagen binding site; other site 997761017360 substrate specificity loop; other site 997761017361 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 997761017362 UvrB/uvrC motif; Region: UVR; pfam02151 997761017363 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 997761017364 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 997761017365 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 997761017366 dimer interface [polypeptide binding]; other site 997761017367 putative anticodon binding site; other site 997761017368 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 997761017369 motif 1; other site 997761017370 active site 997761017371 motif 2; other site 997761017372 motif 3; other site 997761017373 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 997761017374 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 997761017375 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 997761017376 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 997761017377 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 997761017378 FMN binding site [chemical binding]; other site 997761017379 active site 997761017380 catalytic residues [active] 997761017381 substrate binding site [chemical binding]; other site 997761017382 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761017383 non-specific DNA binding site [nucleotide binding]; other site 997761017384 salt bridge; other site 997761017385 sequence-specific DNA binding site [nucleotide binding]; other site 997761017386 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 997761017387 catalytic center binding site [active] 997761017388 ATP binding site [chemical binding]; other site 997761017389 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 997761017390 homooctamer interface [polypeptide binding]; other site 997761017391 active site 997761017392 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 997761017393 dihydropteroate synthase; Region: DHPS; TIGR01496 997761017394 substrate binding pocket [chemical binding]; other site 997761017395 dimer interface [polypeptide binding]; other site 997761017396 inhibitor binding site; inhibition site 997761017397 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 997761017398 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 997761017399 homodimer interface [polypeptide binding]; other site 997761017400 substrate-cofactor binding pocket; other site 997761017401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761017402 catalytic residue [active] 997761017403 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 997761017404 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 997761017405 glutamine binding [chemical binding]; other site 997761017406 catalytic triad [active] 997761017407 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 997761017408 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 997761017409 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 997761017410 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 997761017411 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 997761017412 dimer interface [polypeptide binding]; other site 997761017413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 997761017414 catalytic residue [active] 997761017415 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 997761017416 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 997761017417 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 997761017418 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 997761017419 dimerization interface [polypeptide binding]; other site 997761017420 domain crossover interface; other site 997761017421 redox-dependent activation switch; other site 997761017422 pantothenate kinase; Reviewed; Region: PRK13318 997761017423 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 997761017424 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 997761017425 dimerization interface [polypeptide binding]; other site 997761017426 active site 997761017427 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 997761017428 L-aspartate oxidase; Provisional; Region: PRK06175 997761017429 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 997761017430 Quinolinate synthetase A protein; Region: NadA; pfam02445 997761017431 FtsH Extracellular; Region: FtsH_ext; pfam06480 997761017432 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 997761017433 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761017434 Walker A motif; other site 997761017435 ATP binding site [chemical binding]; other site 997761017436 Walker B motif; other site 997761017437 arginine finger; other site 997761017438 Peptidase family M41; Region: Peptidase_M41; pfam01434 997761017439 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 997761017440 active site 997761017441 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 997761017442 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 997761017443 Ligand Binding Site [chemical binding]; other site 997761017444 TilS substrate C-terminal domain; Region: TilS_C; smart00977 997761017445 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 997761017446 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 997761017447 active site 997761017448 ATP binding site [chemical binding]; other site 997761017449 substrate binding site [chemical binding]; other site 997761017450 activation loop (A-loop); other site 997761017451 stage II sporulation protein E; Region: spore_II_E; TIGR02865 997761017452 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 997761017453 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 997761017454 RNA binding site [nucleotide binding]; other site 997761017455 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 997761017456 Septum formation initiator; Region: DivIC; pfam04977 997761017457 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 997761017458 YabP family; Region: YabP; cl06766 997761017459 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 997761017460 RNA binding surface [nucleotide binding]; other site 997761017461 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 997761017462 IHF dimer interface [polypeptide binding]; other site 997761017463 IHF - DNA interface [nucleotide binding]; other site 997761017464 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 997761017465 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 997761017466 putative SAM binding site [chemical binding]; other site 997761017467 putative homodimer interface [polypeptide binding]; other site 997761017468 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 997761017469 homodimer interface [polypeptide binding]; other site 997761017470 metal binding site [ion binding]; metal-binding site 997761017471 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 997761017472 homodimer interface [polypeptide binding]; other site 997761017473 active site 997761017474 putative chemical substrate binding site [chemical binding]; other site 997761017475 metal binding site [ion binding]; metal-binding site 997761017476 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 997761017477 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 997761017478 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 997761017479 ATP binding site [chemical binding]; other site 997761017480 putative Mg++ binding site [ion binding]; other site 997761017481 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 997761017482 nucleotide binding region [chemical binding]; other site 997761017483 ATP-binding site [chemical binding]; other site 997761017484 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 997761017485 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 997761017486 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 997761017487 putative active site [active] 997761017488 catalytic residue [active] 997761017489 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 997761017490 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 997761017491 5S rRNA interface [nucleotide binding]; other site 997761017492 CTC domain interface [polypeptide binding]; other site 997761017493 L16 interface [polypeptide binding]; other site 997761017494 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 997761017495 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 997761017496 Substrate binding site; other site 997761017497 Mg++ binding site; other site 997761017498 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 997761017499 active site 997761017500 substrate binding site [chemical binding]; other site 997761017501 CoA binding site [chemical binding]; other site 997761017502 regulatory protein SpoVG; Reviewed; Region: PRK13259 997761017503 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 997761017504 homotrimer interaction site [polypeptide binding]; other site 997761017505 putative active site [active] 997761017506 pur operon repressor; Provisional; Region: PRK09213 997761017507 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 997761017508 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 997761017509 active site 997761017510 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 997761017511 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 997761017512 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 997761017513 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761017514 S-adenosylmethionine binding site [chemical binding]; other site 997761017515 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 997761017516 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 997761017517 putative active site [active] 997761017518 putative metal binding site [ion binding]; other site 997761017519 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 997761017520 Domain of unknown function (DUF348); Region: DUF348; pfam03990 997761017521 Domain of unknown function (DUF348); Region: DUF348; pfam03990 997761017522 G5 domain; Region: G5; pfam07501 997761017523 3D domain; Region: 3D; cl01439 997761017524 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 997761017525 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 997761017526 active site 997761017527 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 997761017528 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 997761017529 Zn2+ binding site [ion binding]; other site 997761017530 Mg2+ binding site [ion binding]; other site 997761017531 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 997761017532 Predicted methyltransferases [General function prediction only]; Region: COG0313 997761017533 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 997761017534 putative SAM binding site [chemical binding]; other site 997761017535 putative homodimer interface [polypeptide binding]; other site 997761017536 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 997761017537 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761017538 S-adenosylmethionine binding site [chemical binding]; other site 997761017539 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 997761017540 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 997761017541 DNA polymerase III subunit delta'; Validated; Region: PRK08058 997761017542 DNA polymerase III subunit delta'; Validated; Region: PRK08485 997761017543 Protein of unknown function (DUF327); Region: DUF327; pfam03885 997761017544 Protein of unknown function (DUF970); Region: DUF970; pfam06153 997761017545 thymidylate kinase; Validated; Region: tmk; PRK00698 997761017546 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 997761017547 TMP-binding site; other site 997761017548 ATP-binding site [chemical binding]; other site 997761017549 Orn/Lys/Arg decarboxylase, major domain; Region: OKR_DC_1; pfam01276 997761017550 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 997761017551 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 997761017552 catalytic residue [active] 997761017553 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 997761017554 SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466 997761017555 recombination protein RecR; Reviewed; Region: recR; PRK00076 997761017556 RecR protein; Region: RecR; pfam02132 997761017557 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 997761017558 putative active site [active] 997761017559 putative metal-binding site [ion binding]; other site 997761017560 tetramer interface [polypeptide binding]; other site 997761017561 hypothetical protein; Validated; Region: PRK00153 997761017562 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 997761017563 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761017564 Walker A motif; other site 997761017565 ATP binding site [chemical binding]; other site 997761017566 Walker B motif; other site 997761017567 arginine finger; other site 997761017568 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 997761017569 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 997761017570 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 997761017571 putative active site [active] 997761017572 heme pocket [chemical binding]; other site 997761017573 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761017574 dimer interface [polypeptide binding]; other site 997761017575 phosphorylation site [posttranslational modification] 997761017576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761017577 ATP binding site [chemical binding]; other site 997761017578 Mg2+ binding site [ion binding]; other site 997761017579 G-X-G motif; other site 997761017580 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 997761017581 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 997761017582 Radical SAM superfamily; Region: Radical_SAM; pfam04055 997761017583 FeS/SAM binding site; other site 997761017584 transcription termination factor Rho; Provisional; Region: rho; PRK09376 997761017585 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 997761017586 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 997761017587 RNA binding site [nucleotide binding]; other site 997761017588 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 997761017589 multimer interface [polypeptide binding]; other site 997761017590 Walker A motif; other site 997761017591 ATP binding site [chemical binding]; other site 997761017592 Walker B motif; other site 997761017593 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 997761017594 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 997761017595 intersubunit interface [polypeptide binding]; other site 997761017596 active site 997761017597 zinc binding site [ion binding]; other site 997761017598 Na+ binding site [ion binding]; other site 997761017599 Response regulator receiver domain; Region: Response_reg; pfam00072 997761017600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761017601 active site 997761017602 phosphorylation site [posttranslational modification] 997761017603 intermolecular recognition site; other site 997761017604 dimerization interface [polypeptide binding]; other site 997761017605 CTP synthetase; Validated; Region: pyrG; PRK05380 997761017606 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 997761017607 Catalytic site [active] 997761017608 active site 997761017609 UTP binding site [chemical binding]; other site 997761017610 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 997761017611 active site 997761017612 putative oxyanion hole; other site 997761017613 catalytic triad [active] 997761017614 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 997761017615 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 997761017616 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 997761017617 active site 997761017618 catalytic residues [active] 997761017619 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761017620 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 997761017621 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761017622 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 997761017623 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 997761017624 putative active site [active] 997761017625 putative metal binding site [ion binding]; other site 997761017626 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 997761017627 agmatinase; Region: agmatinase; TIGR01230 997761017628 Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593 997761017629 putative active site [active] 997761017630 Mn binding site [ion binding]; other site 997761017631 spermidine synthase; Provisional; Region: PRK00811 997761017632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761017633 The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880 997761017634 YwhD family; Region: YwhD; pfam08741 997761017635 NlpC/P60 family; Region: NLPC_P60; pfam00877 997761017636 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 997761017637 DNA photolyase; Region: DNA_photolyase; pfam00875 997761017638 PspC domain; Region: PspC; pfam04024 997761017639 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 997761017640 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 997761017641 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 997761017642 active site residue [active] 997761017643 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 997761017644 active site residue [active] 997761017645 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 997761017646 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 997761017647 Phosphoribosyl-dephospho-CoA transferase MdcG; Region: MdcG; pfam10620 997761017648 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761017649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761017650 dimer interface [polypeptide binding]; other site 997761017651 putative CheW interface [polypeptide binding]; other site 997761017652 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 997761017653 aromatic arch; other site 997761017654 DCoH dimer interaction site [polypeptide binding]; other site 997761017655 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 997761017656 DCoH tetramer interaction site [polypeptide binding]; other site 997761017657 substrate binding site [chemical binding]; other site 997761017658 Uncharacterized conserved protein [Function unknown]; Region: COG2308 997761017659 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 997761017660 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 997761017661 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 997761017662 NAD binding site [chemical binding]; other site 997761017663 homodimer interface [polypeptide binding]; other site 997761017664 active site 997761017665 substrate binding site [chemical binding]; other site 997761017666 galactokinase; Provisional; Region: PRK05322 997761017667 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 997761017668 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 997761017669 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 997761017670 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 997761017671 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761017672 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761017673 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761017674 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 997761017675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761017676 dimer interface [polypeptide binding]; other site 997761017677 phosphorylation site [posttranslational modification] 997761017678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761017679 ATP binding site [chemical binding]; other site 997761017680 Mg2+ binding site [ion binding]; other site 997761017681 G-X-G motif; other site 997761017682 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761017683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761017684 active site 997761017685 phosphorylation site [posttranslational modification] 997761017686 intermolecular recognition site; other site 997761017687 dimerization interface [polypeptide binding]; other site 997761017688 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761017689 DNA binding site [nucleotide binding] 997761017690 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 997761017691 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 997761017692 RNA binding surface [nucleotide binding]; other site 997761017693 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 997761017694 probable active site [active] 997761017695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 997761017696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761017697 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761017698 putative substrate translocation pore; other site 997761017699 Major Facilitator Superfamily; Region: MFS_1; pfam07690 997761017700 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761017701 putative substrate translocation pore; other site 997761017702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761017703 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 997761017704 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761017705 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 997761017706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761017707 motif II; other site 997761017708 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 997761017709 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 997761017710 putative FMN binding site [chemical binding]; other site 997761017711 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 997761017712 putative active site [active] 997761017713 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 997761017714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761017715 putative substrate translocation pore; other site 997761017716 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 997761017717 HlyD family secretion protein; Region: HlyD_3; pfam13437 997761017718 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 997761017719 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 997761017720 E3 interaction surface; other site 997761017721 lipoyl attachment site [posttranslational modification]; other site 997761017722 HlyD family secretion protein; Region: HlyD_3; pfam13437 997761017723 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761017724 MarR family; Region: MarR; pfam01047 997761017725 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761017726 MarR family; Region: MarR_2; pfam12802 997761017727 Methyltransferase domain; Region: Methyltransf_31; pfam13847 997761017728 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761017729 S-adenosylmethionine binding site [chemical binding]; other site 997761017730 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 997761017731 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 997761017732 xanthine permease; Region: pbuX; TIGR03173 997761017733 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 997761017734 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761017735 dimer interface [polypeptide binding]; other site 997761017736 conserved gate region; other site 997761017737 putative PBP binding loops; other site 997761017738 ABC-ATPase subunit interface; other site 997761017739 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761017740 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761017741 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761017742 active site 997761017743 phosphorylation site [posttranslational modification] 997761017744 intermolecular recognition site; other site 997761017745 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761017746 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761017747 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761017748 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761017749 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761017750 dimerization interface [polypeptide binding]; other site 997761017751 Histidine kinase; Region: His_kinase; pfam06580 997761017752 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761017753 ATP binding site [chemical binding]; other site 997761017754 Mg2+ binding site [ion binding]; other site 997761017755 G-X-G motif; other site 997761017756 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 997761017757 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 997761017758 dimerization interface [polypeptide binding]; other site 997761017759 DPS ferroxidase diiron center [ion binding]; other site 997761017760 ion pore; other site 997761017761 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 997761017762 SpoOM protein; Region: Spo0M; pfam07070 997761017763 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 997761017764 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 997761017765 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 997761017766 putative active site [active] 997761017767 catalytic site [active] 997761017768 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 997761017769 putative active site [active] 997761017770 catalytic site [active] 997761017771 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 997761017772 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 997761017773 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 997761017774 active site 997761017775 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 997761017776 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761017777 putative DNA binding site [nucleotide binding]; other site 997761017778 putative Zn2+ binding site [ion binding]; other site 997761017779 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 997761017780 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 997761017781 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 997761017782 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761017783 non-specific DNA binding site [nucleotide binding]; other site 997761017784 salt bridge; other site 997761017785 sequence-specific DNA binding site [nucleotide binding]; other site 997761017786 Cupin domain; Region: Cupin_2; pfam07883 997761017787 Methyltransferase domain; Region: Methyltransf_23; pfam13489 997761017788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761017789 S-adenosylmethionine binding site [chemical binding]; other site 997761017790 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 997761017791 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 997761017792 apolar tunnel; other site 997761017793 heme binding site [chemical binding]; other site 997761017794 dimerization interface [polypeptide binding]; other site 997761017795 Uncharacterized conserved protein [Function unknown]; Region: COG1801 997761017796 prolyl-tRNA synthetase; Provisional; Region: PRK09194 997761017797 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 997761017798 dimer interface [polypeptide binding]; other site 997761017799 motif 1; other site 997761017800 active site 997761017801 motif 2; other site 997761017802 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 997761017803 putative deacylase active site [active] 997761017804 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 997761017805 active site 997761017806 motif 3; other site 997761017807 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 997761017808 anticodon binding site; other site 997761017809 EcsC protein family; Region: EcsC; pfam12787 997761017810 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 997761017811 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 997761017812 major capsid L1 protein; Provisional; Region: PHA02778 997761017813 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 997761017814 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 997761017815 active site 997761017816 HIGH motif; other site 997761017817 nucleotide binding site [chemical binding]; other site 997761017818 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 997761017819 KMSKS motif; other site 997761017820 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 997761017821 GTPase RsgA; Reviewed; Region: PRK01889 997761017822 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 997761017823 RNA binding site [nucleotide binding]; other site 997761017824 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 997761017825 GTPase/Zn-binding domain interface [polypeptide binding]; other site 997761017826 GTP/Mg2+ binding site [chemical binding]; other site 997761017827 G4 box; other site 997761017828 G5 box; other site 997761017829 G1 box; other site 997761017830 Switch I region; other site 997761017831 G2 box; other site 997761017832 G3 box; other site 997761017833 Switch II region; other site 997761017834 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 997761017835 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761017836 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 997761017837 putative Zn2+ binding site [ion binding]; other site 997761017838 putative DNA binding site [nucleotide binding]; other site 997761017839 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 997761017840 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761017841 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 997761017842 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 997761017843 Glutamate binding site [chemical binding]; other site 997761017844 homodimer interface [polypeptide binding]; other site 997761017845 NAD binding site [chemical binding]; other site 997761017846 catalytic residues [active] 997761017847 Proline dehydrogenase; Region: Pro_dh; cl03282 997761017848 PAS domain; Region: PAS_9; pfam13426 997761017849 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 997761017850 putative active site [active] 997761017851 heme pocket [chemical binding]; other site 997761017852 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 997761017853 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 997761017854 Walker A motif; other site 997761017855 ATP binding site [chemical binding]; other site 997761017856 Walker B motif; other site 997761017857 arginine finger; other site 997761017858 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 997761017859 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 997761017860 pentamer interface [polypeptide binding]; other site 997761017861 dodecaamer interface [polypeptide binding]; other site 997761017862 Uncharacterized conserved protein [Function unknown]; Region: COG0398 997761017863 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 997761017864 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 997761017865 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 997761017866 Coenzyme A binding pocket [chemical binding]; other site 997761017867 Heat induced stress protein YflT; Region: YflT; pfam11181 997761017868 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 997761017869 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761017870 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 997761017871 Walker A/P-loop; other site 997761017872 ATP binding site [chemical binding]; other site 997761017873 Q-loop/lid; other site 997761017874 ABC transporter signature motif; other site 997761017875 Walker B; other site 997761017876 D-loop; other site 997761017877 H-loop/switch region; other site 997761017878 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 997761017879 Catalytic site [active] 997761017880 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 997761017881 SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249 997761017882 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 997761017883 Fe-S cluster binding site [ion binding]; other site 997761017884 active site 997761017885 GAF domain; Region: GAF; pfam01590 997761017886 GAF domain; Region: GAF_2; pfam13185 997761017887 PAS domain S-box; Region: sensory_box; TIGR00229 997761017888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761017889 putative active site [active] 997761017890 heme pocket [chemical binding]; other site 997761017891 PAS domain; Region: PAS_9; pfam13426 997761017892 PAS domain S-box; Region: sensory_box; TIGR00229 997761017893 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761017894 putative active site [active] 997761017895 heme pocket [chemical binding]; other site 997761017896 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761017897 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761017898 metal binding site [ion binding]; metal-binding site 997761017899 active site 997761017900 I-site; other site 997761017901 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 997761017902 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 997761017903 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 997761017904 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 997761017905 active site 997761017906 Zn binding site [ion binding]; other site 997761017907 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 997761017908 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 997761017909 DEAD/DEAH box helicase; Region: DEAD; pfam00270 997761017910 DEAD_2; Region: DEAD_2; pfam06733 997761017911 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 997761017912 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 997761017913 MarR family; Region: MarR; pfam01047 997761017914 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 997761017915 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761017916 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761017917 Walker A/P-loop; other site 997761017918 ATP binding site [chemical binding]; other site 997761017919 Q-loop/lid; other site 997761017920 ABC transporter signature motif; other site 997761017921 Walker B; other site 997761017922 D-loop; other site 997761017923 H-loop/switch region; other site 997761017924 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 997761017925 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 997761017926 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 997761017927 Walker A/P-loop; other site 997761017928 ATP binding site [chemical binding]; other site 997761017929 Q-loop/lid; other site 997761017930 ABC transporter signature motif; other site 997761017931 Walker B; other site 997761017932 D-loop; other site 997761017933 H-loop/switch region; other site 997761017934 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 997761017935 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 997761017936 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 997761017937 dimerization interface [polypeptide binding]; other site 997761017938 DPS ferroxidase diiron center [ion binding]; other site 997761017939 ion pore; other site 997761017940 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 997761017941 metal binding site 2 [ion binding]; metal-binding site 997761017942 putative DNA binding helix; other site 997761017943 metal binding site 1 [ion binding]; metal-binding site 997761017944 dimer interface [polypeptide binding]; other site 997761017945 structural Zn2+ binding site [ion binding]; other site 997761017946 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761017947 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761017948 DNA binding site [nucleotide binding] 997761017949 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 997761017950 metal binding site 2 [ion binding]; metal-binding site 997761017951 putative DNA binding helix; other site 997761017952 metal binding site 1 [ion binding]; metal-binding site 997761017953 dimer interface [polypeptide binding]; other site 997761017954 structural Zn2+ binding site [ion binding]; other site 997761017955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 997761017956 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 997761017957 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 997761017958 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 997761017959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761017960 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 997761017961 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 997761017962 active site 997761017963 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 997761017964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761017965 dimer interface [polypeptide binding]; other site 997761017966 conserved gate region; other site 997761017967 ABC-ATPase subunit interface; other site 997761017968 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761017969 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761017970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761017971 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 997761017972 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 997761017973 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 997761017974 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761017975 dimerization interface [polypeptide binding]; other site 997761017976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761017977 dimer interface [polypeptide binding]; other site 997761017978 phosphorylation site [posttranslational modification] 997761017979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761017980 ATP binding site [chemical binding]; other site 997761017981 Mg2+ binding site [ion binding]; other site 997761017982 G-X-G motif; other site 997761017983 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761017984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761017985 active site 997761017986 phosphorylation site [posttranslational modification] 997761017987 intermolecular recognition site; other site 997761017988 dimerization interface [polypeptide binding]; other site 997761017989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761017990 DNA binding site [nucleotide binding] 997761017991 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 997761017992 non-specific DNA binding site [nucleotide binding]; other site 997761017993 salt bridge; other site 997761017994 sequence-specific DNA binding site [nucleotide binding]; other site 997761017995 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 997761017996 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 997761017997 non-specific DNA binding site [nucleotide binding]; other site 997761017998 salt bridge; other site 997761017999 sequence-specific DNA binding site [nucleotide binding]; other site 997761018000 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 997761018001 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 997761018002 Walker A/P-loop; other site 997761018003 ATP binding site [chemical binding]; other site 997761018004 Q-loop/lid; other site 997761018005 ABC transporter signature motif; other site 997761018006 Walker B; other site 997761018007 D-loop; other site 997761018008 H-loop/switch region; other site 997761018009 PAS domain S-box; Region: sensory_box; TIGR00229 997761018010 PAS domain; Region: PAS_8; pfam13188 997761018011 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 997761018012 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 997761018013 metal binding site [ion binding]; metal-binding site 997761018014 active site 997761018015 I-site; other site 997761018016 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 997761018017 Cache domain; Region: Cache_1; pfam02743 997761018018 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761018019 dimerization interface [polypeptide binding]; other site 997761018020 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761018021 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761018022 dimer interface [polypeptide binding]; other site 997761018023 putative CheW interface [polypeptide binding]; other site 997761018024 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 997761018025 Interdomain contacts; other site 997761018026 Cytokine receptor motif; other site 997761018027 Cold-inducible protein YdjO; Region: YdjO; pfam14169 997761018028 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 997761018029 DNA-binding site [nucleotide binding]; DNA binding site 997761018030 RNA-binding motif; other site 997761018031 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 997761018032 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 997761018033 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761018034 dimerization interface [polypeptide binding]; other site 997761018035 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761018036 dimer interface [polypeptide binding]; other site 997761018037 putative CheW interface [polypeptide binding]; other site 997761018038 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 997761018039 glycerol kinase; Provisional; Region: glpK; PRK00047 997761018040 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 997761018041 N- and C-terminal domain interface [polypeptide binding]; other site 997761018042 active site 997761018043 MgATP binding site [chemical binding]; other site 997761018044 catalytic site [active] 997761018045 metal binding site [ion binding]; metal-binding site 997761018046 glycerol binding site [chemical binding]; other site 997761018047 homotetramer interface [polypeptide binding]; other site 997761018048 homodimer interface [polypeptide binding]; other site 997761018049 FBP binding site [chemical binding]; other site 997761018050 protein IIAGlc interface [polypeptide binding]; other site 997761018051 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 997761018052 amphipathic channel; other site 997761018053 Asn-Pro-Ala signature motifs; other site 997761018054 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 997761018055 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 997761018056 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 997761018057 putative ligand binding residues [chemical binding]; other site 997761018058 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 997761018059 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 997761018060 Walker A/P-loop; other site 997761018061 ATP binding site [chemical binding]; other site 997761018062 Q-loop/lid; other site 997761018063 ABC transporter signature motif; other site 997761018064 Walker B; other site 997761018065 D-loop; other site 997761018066 H-loop/switch region; other site 997761018067 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761018068 ABC-ATPase subunit interface; other site 997761018069 dimer interface [polypeptide binding]; other site 997761018070 putative PBP binding regions; other site 997761018071 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 997761018072 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 997761018073 ABC-ATPase subunit interface; other site 997761018074 dimer interface [polypeptide binding]; other site 997761018075 putative PBP binding regions; other site 997761018076 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 997761018077 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 997761018078 Uncharacterized conserved protein [Function unknown]; Region: COG2427 997761018079 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 997761018080 active site 997761018081 HIGH motif; other site 997761018082 nucleotide binding site [chemical binding]; other site 997761018083 active site 997761018084 KMSKS motif; other site 997761018085 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 997761018086 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 997761018087 YceI-like domain; Region: YceI; pfam04264 997761018088 Penicillinase repressor; Region: Pencillinase_R; pfam03965 997761018089 short chain dehydrogenase; Provisional; Region: PRK06701 997761018090 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 997761018091 NAD binding site [chemical binding]; other site 997761018092 metal binding site [ion binding]; metal-binding site 997761018093 active site 997761018094 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 997761018095 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 997761018096 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761018097 dimerization interface [polypeptide binding]; other site 997761018098 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 997761018099 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 997761018100 dimer interface [polypeptide binding]; other site 997761018101 putative CheW interface [polypeptide binding]; other site 997761018102 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 997761018103 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 997761018104 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 997761018105 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 997761018106 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 997761018107 Walker A/P-loop; other site 997761018108 ATP binding site [chemical binding]; other site 997761018109 Q-loop/lid; other site 997761018110 ABC transporter signature motif; other site 997761018111 Walker B; other site 997761018112 D-loop; other site 997761018113 H-loop/switch region; other site 997761018114 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 997761018115 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 997761018116 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 997761018117 Phosphotransferase enzyme family; Region: APH; pfam01636 997761018118 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 997761018119 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 997761018120 putative hydrophobic ligand binding site [chemical binding]; other site 997761018121 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 997761018122 Family description; Region: VCBS; pfam13517 997761018123 Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632 997761018124 putative inhibitory loop; other site 997761018125 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761018126 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761018127 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761018128 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 997761018129 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 997761018130 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 997761018131 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 997761018132 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 997761018133 tetramer interface [polypeptide binding]; other site 997761018134 active site 997761018135 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 997761018136 active site 997761018137 dimer interface [polypeptide binding]; other site 997761018138 magnesium binding site [ion binding]; other site 997761018139 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761018140 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761018141 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 997761018142 classical (c) SDRs; Region: SDR_c; cd05233 997761018143 NAD(P) binding site [chemical binding]; other site 997761018144 active site 997761018145 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 997761018146 Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154 997761018147 tetramer interface [polypeptide binding]; other site 997761018148 heme binding pocket [chemical binding]; other site 997761018149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761018150 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 997761018151 active site 997761018152 motif I; other site 997761018153 motif II; other site 997761018154 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 997761018155 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761018156 S-adenosylmethionine binding site [chemical binding]; other site 997761018157 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 997761018158 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 997761018159 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 997761018160 Walker A/P-loop; other site 997761018161 ATP binding site [chemical binding]; other site 997761018162 Q-loop/lid; other site 997761018163 ABC transporter signature motif; other site 997761018164 Walker B; other site 997761018165 D-loop; other site 997761018166 H-loop/switch region; other site 997761018167 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 997761018168 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 997761018169 dimer interface [polypeptide binding]; other site 997761018170 conserved gate region; other site 997761018171 putative PBP binding loops; other site 997761018172 ABC-ATPase subunit interface; other site 997761018173 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 997761018174 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 997761018175 substrate binding pocket [chemical binding]; other site 997761018176 membrane-bound complex binding site; other site 997761018177 hinge residues; other site 997761018178 Uncharacterized conserved protein [Function unknown]; Region: COG0398 997761018179 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 997761018180 Uncharacterized conserved protein [Function unknown]; Region: COG0398 997761018181 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 997761018182 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 997761018183 Uncharacterized conserved protein [Function unknown]; Region: COG2966 997761018184 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 997761018185 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 997761018186 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 997761018187 active site 997761018188 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 997761018189 DNA binding site [nucleotide binding] 997761018190 active site 997761018191 CsbD-like; Region: CsbD; pfam05532 997761018192 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 997761018193 S-adenosylmethionine binding site [chemical binding]; other site 997761018194 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 997761018195 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 997761018196 ATP binding site [chemical binding]; other site 997761018197 Mg++ binding site [ion binding]; other site 997761018198 motif III; other site 997761018199 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 997761018200 nucleotide binding region [chemical binding]; other site 997761018201 ATP-binding site [chemical binding]; other site 997761018202 RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500 997761018203 RNA binding site [nucleotide binding]; other site 997761018204 Predicted transcriptional regulators [Transcription]; Region: COG1733 997761018205 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 997761018206 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 997761018207 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761018208 putative substrate translocation pore; other site 997761018209 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 997761018210 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 997761018211 active site 997761018212 catalytic tetrad [active] 997761018213 xanthine permease; Region: pbuX; TIGR03173 997761018214 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 997761018215 active site 997761018216 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 997761018217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761018218 putative substrate translocation pore; other site 997761018219 POT family; Region: PTR2; cl17359 997761018220 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 997761018221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 997761018222 putative substrate translocation pore; other site 997761018223 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 997761018224 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 997761018225 PhnA protein; Region: PhnA; pfam03831 997761018226 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 997761018227 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 997761018228 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 997761018229 Predicted transcriptional regulator [Transcription]; Region: COG2378 997761018230 HTH domain; Region: HTH_11; pfam08279 997761018231 WYL domain; Region: WYL; pfam13280 997761018232 hypothetical protein; Provisional; Region: PRK02268 997761018233 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 997761018234 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 997761018235 ATP binding site [chemical binding]; other site 997761018236 Mg++ binding site [ion binding]; other site 997761018237 motif III; other site 997761018238 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 997761018239 nucleotide binding region [chemical binding]; other site 997761018240 ATP-binding site [chemical binding]; other site 997761018241 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 997761018242 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 997761018243 dimerization interface [polypeptide binding]; other site 997761018244 DPS ferroxidase diiron center [ion binding]; other site 997761018245 ion pore; other site 997761018246 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 997761018247 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 997761018248 TAP-like protein; Region: Abhydrolase_4; pfam08386 997761018249 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761018250 ATP binding site [chemical binding]; other site 997761018251 Mg2+ binding site [ion binding]; other site 997761018252 G-X-G motif; other site 997761018253 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 997761018254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761018255 active site 997761018256 phosphorylation site [posttranslational modification] 997761018257 intermolecular recognition site; other site 997761018258 dimerization interface [polypeptide binding]; other site 997761018259 LytTr DNA-binding domain; Region: LytTR; smart00850 997761018260 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 997761018261 YyzF-like protein; Region: YyzF; pfam14116 997761018262 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 997761018263 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 997761018264 protein binding site [polypeptide binding]; other site 997761018265 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 997761018266 YycH protein; Region: YycI; cl02015 997761018267 YycH protein; Region: YycH; pfam07435 997761018268 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 997761018269 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 997761018270 dimerization interface [polypeptide binding]; other site 997761018271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 997761018272 putative active site [active] 997761018273 heme pocket [chemical binding]; other site 997761018274 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 997761018275 dimer interface [polypeptide binding]; other site 997761018276 phosphorylation site [posttranslational modification] 997761018277 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 997761018278 ATP binding site [chemical binding]; other site 997761018279 Mg2+ binding site [ion binding]; other site 997761018280 G-X-G motif; other site 997761018281 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 997761018282 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 997761018283 active site 997761018284 phosphorylation site [posttranslational modification] 997761018285 intermolecular recognition site; other site 997761018286 dimerization interface [polypeptide binding]; other site 997761018287 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 997761018288 DNA binding site [nucleotide binding] 997761018289 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 997761018290 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 997761018291 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 997761018292 G5 domain; Region: G5; pfam07501 997761018293 Peptidase family M23; Region: Peptidase_M23; pfam01551 997761018294 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 997761018295 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 997761018296 GDP-binding site [chemical binding]; other site 997761018297 ACT binding site; other site 997761018298 IMP binding site; other site 997761018299 replicative DNA helicase; Provisional; Region: PRK05748 997761018300 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 997761018301 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 997761018302 Walker A motif; other site 997761018303 ATP binding site [chemical binding]; other site 997761018304 Walker B motif; other site 997761018305 DNA binding loops [nucleotide binding] 997761018306 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 997761018307 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 997761018308 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 997761018309 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 997761018310 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 997761018311 DHH family; Region: DHH; pfam01368 997761018312 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 997761018313 MazG-like family; Region: MazG-like; pfam12643 997761018314 FOG: CBS domain [General function prediction only]; Region: COG0517 997761018315 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 997761018316 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 997761018317 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 997761018318 YjzC-like protein; Region: YjzC; pfam14168 997761018319 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 997761018320 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 997761018321 Mechanosensitive ion channel; Region: MS_channel; pfam00924 997761018322 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 997761018323 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 997761018324 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 997761018325 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 997761018326 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 997761018327 catalytic residue [active] 997761018328 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 997761018329 ParB-like nuclease domain; Region: ParB; smart00470 997761018330 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 997761018331 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 997761018332 P-loop; other site 997761018333 Magnesium ion binding site [ion binding]; other site 997761018334 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 997761018335 Magnesium ion binding site [ion binding]; other site 997761018336 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 997761018337 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 997761018338 ParB-like nuclease domain; Region: ParB; smart00470 997761018339 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 997761018340 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 997761018341 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 997761018342 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 997761018343 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 997761018344 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 997761018345 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 997761018346 trmE is a tRNA modification GTPase; Region: trmE; cd04164 997761018347 G1 box; other site 997761018348 GTP/Mg2+ binding site [chemical binding]; other site 997761018349 Switch I region; other site 997761018350 G2 box; other site 997761018351 Switch II region; other site 997761018352 G3 box; other site 997761018353 G4 box; other site 997761018354 G5 box; other site 997761018355 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 997761018356 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 997761018357 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 997761018358 G-X-X-G motif; other site 997761018359 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 997761018360 RxxxH motif; other site 997761018361 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 997761018362 ribonuclease P; Reviewed; Region: rnpA; PRK00499 997761018363 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399