-- dump date   	20140619_225546
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1036673000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1036673000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1036673000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673000004	Walker A motif; other site
1036673000005	ATP binding site [chemical binding]; other site
1036673000006	Walker B motif; other site
1036673000007	arginine finger; other site
1036673000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1036673000009	DnaA box-binding interface [nucleotide binding]; other site
1036673000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
1036673000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1036673000012	putative DNA binding surface [nucleotide binding]; other site
1036673000013	dimer interface [polypeptide binding]; other site
1036673000014	beta-clamp/clamp loader binding surface; other site
1036673000015	beta-clamp/translesion DNA polymerase binding surface; other site
1036673000016	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
1036673000017	recombination protein F; Reviewed; Region: recF; PRK00064
1036673000018	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1036673000019	Walker A/P-loop; other site
1036673000020	ATP binding site [chemical binding]; other site
1036673000021	Q-loop/lid; other site
1036673000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673000023	ABC transporter signature motif; other site
1036673000024	Walker B; other site
1036673000025	D-loop; other site
1036673000026	H-loop/switch region; other site
1036673000027	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1036673000028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673000029	Mg2+ binding site [ion binding]; other site
1036673000030	G-X-G motif; other site
1036673000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1036673000032	anchoring element; other site
1036673000033	dimer interface [polypeptide binding]; other site
1036673000034	ATP binding site [chemical binding]; other site
1036673000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1036673000036	active site
1036673000037	putative metal-binding site [ion binding]; other site
1036673000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1036673000039	DNA gyrase subunit A; Validated; Region: PRK05560
1036673000040	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1036673000041	CAP-like domain; other site
1036673000042	active site
1036673000043	primary dimer interface [polypeptide binding]; other site
1036673000044	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036673000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036673000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036673000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036673000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036673000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036673000050	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1036673000051	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036673000052	Zn2+ binding site [ion binding]; other site
1036673000053	Mg2+ binding site [ion binding]; other site
1036673000054	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1036673000055	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1036673000056	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1036673000057	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1036673000058	active site
1036673000059	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1036673000060	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1036673000061	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1036673000062	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1036673000063	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1036673000064	active site
1036673000065	multimer interface [polypeptide binding]; other site
1036673000066	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
1036673000067	predicted active site [active]
1036673000068	catalytic triad [active]
1036673000069	seryl-tRNA synthetase; Provisional; Region: PRK05431
1036673000070	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1036673000071	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1036673000072	dimer interface [polypeptide binding]; other site
1036673000073	active site
1036673000074	motif 1; other site
1036673000075	motif 2; other site
1036673000076	motif 3; other site
1036673000077	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1036673000078	Part of AAA domain; Region: AAA_19; pfam13245
1036673000079	Family description; Region: UvrD_C_2; pfam13538
1036673000080	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1036673000081	active site
1036673000082	RNA polymerase sigma factor SigW; Reviewed; Region: PRK09642
1036673000083	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673000084	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673000085	DNA binding residues [nucleotide binding]
1036673000086	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1036673000087	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1036673000088	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1036673000089	nucleoside/Zn binding site; other site
1036673000090	dimer interface [polypeptide binding]; other site
1036673000091	catalytic motif [active]
1036673000092	PilZ domain; Region: PilZ; pfam07238
1036673000093	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1036673000094	amidase catalytic site [active]
1036673000095	Zn binding residues [ion binding]; other site
1036673000096	substrate binding site [chemical binding]; other site
1036673000097	GTP-binding protein YchF; Reviewed; Region: PRK09601
1036673000098	YchF GTPase; Region: YchF; cd01900
1036673000099	G1 box; other site
1036673000100	GTP/Mg2+ binding site [chemical binding]; other site
1036673000101	Switch I region; other site
1036673000102	G2 box; other site
1036673000103	Switch II region; other site
1036673000104	G3 box; other site
1036673000105	G4 box; other site
1036673000106	G5 box; other site
1036673000107	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1036673000108	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1036673000109	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1036673000110	RF-1 domain; Region: RF-1; pfam00472
1036673000111	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1036673000112	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673000113	S-adenosylmethionine binding site [chemical binding]; other site
1036673000114	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
1036673000115	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1036673000116	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1036673000117	Predicted membrane protein [Function unknown]; Region: COG1971
1036673000118	Domain of unknown function DUF; Region: DUF204; pfam02659
1036673000119	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1036673000120	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1036673000121	active site
1036673000122	ribose-5-phosphate isomerase B; Provisional; Region: PRK05571
1036673000123	hypothetical protein; Provisional; Region: PRK13690
1036673000124	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1036673000125	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1036673000126	dimer interface [polypeptide binding]; other site
1036673000127	active site
1036673000128	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1036673000129	folate binding site [chemical binding]; other site
1036673000130	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036673000131	active site
1036673000132	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1036673000133	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1036673000134	active site
1036673000135	homodimer interface [polypeptide binding]; other site
1036673000136	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1036673000137	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1036673000138	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
1036673000139	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1036673000140	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1036673000141	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1036673000142	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1036673000143	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1036673000144	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1036673000145	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1036673000146	beta subunit interaction interface [polypeptide binding]; other site
1036673000147	Walker A motif; other site
1036673000148	ATP binding site [chemical binding]; other site
1036673000149	Walker B motif; other site
1036673000150	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1036673000151	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1036673000152	core domain interface [polypeptide binding]; other site
1036673000153	delta subunit interface [polypeptide binding]; other site
1036673000154	epsilon subunit interface [polypeptide binding]; other site
1036673000155	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1036673000156	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1036673000157	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1036673000158	alpha subunit interaction interface [polypeptide binding]; other site
1036673000159	Walker A motif; other site
1036673000160	ATP binding site [chemical binding]; other site
1036673000161	Walker B motif; other site
1036673000162	inhibitor binding site; inhibition site
1036673000163	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1036673000164	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1036673000165	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1036673000166	gamma subunit interface [polypeptide binding]; other site
1036673000167	epsilon subunit interface [polypeptide binding]; other site
1036673000168	LBP interface [polypeptide binding]; other site
1036673000169	NADH dehydrogenase subunit A; Validated; Region: PRK07756
1036673000170	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1036673000171	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917
1036673000172	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1036673000173	NADH dehydrogenase subunit D; Provisional; Region: PRK12322
1036673000174	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1036673000175	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1036673000176	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
1036673000177	4Fe-4S binding domain; Region: Fer4; pfam00037
1036673000178	4Fe-4S binding domain; Region: Fer4; cl02805
1036673000179	NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; Region: NuoJ; COG0839
1036673000180	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1036673000181	NADH dehydrogenase subunit J; Provisional; Region: PRK06439
1036673000182	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1036673000183	proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974
1036673000184	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1036673000185	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1036673000186	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1036673000187	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1036673000188	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1036673000189	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673000190	MarR family; Region: MarR; pfam01047
1036673000191	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1036673000192	active site
1036673000193	catalytic residues [active]
1036673000194	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1036673000195	S-layer homology domain; Region: SLH; pfam00395
1036673000196	S-layer homology domain; Region: SLH; pfam00395
1036673000197	S-layer homology domain; Region: SLH; pfam00395
1036673000198	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
1036673000199	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1036673000200	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1036673000201	hinge; other site
1036673000202	active site
1036673000203	stage II sporulation protein D; Region: spore_II_D; TIGR02870
1036673000204	Stage II sporulation protein; Region: SpoIID; pfam08486
1036673000205	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1036673000206	Peptidase family M23; Region: Peptidase_M23; pfam01551
1036673000207	Stage III sporulation protein D; Region: SpoIIID; pfam12116
1036673000208	rod shape-determining protein Mbl; Provisional; Region: PRK13928
1036673000209	MreB and similar proteins; Region: MreB_like; cd10225
1036673000210	nucleotide binding site [chemical binding]; other site
1036673000211	Mg binding site [ion binding]; other site
1036673000212	putative protofilament interaction site [polypeptide binding]; other site
1036673000213	RodZ interaction site [polypeptide binding]; other site
1036673000214	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
1036673000215	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1036673000216	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1036673000217	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
1036673000218	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1036673000219	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1036673000220	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
1036673000221	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1036673000222	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1036673000223	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1036673000224	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1036673000225	active site
1036673000226	substrate binding site [chemical binding]; other site
1036673000227	metal binding site [ion binding]; metal-binding site
1036673000228	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
1036673000229	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1036673000230	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1036673000231	Mg++ binding site [ion binding]; other site
1036673000232	putative catalytic motif [active]
1036673000233	substrate binding site [chemical binding]; other site
1036673000234	S-layer homology domain; Region: SLH; pfam00395
1036673000235	S-layer homology domain; Region: SLH; pfam00395
1036673000236	S-layer homology domain; Region: SLH; pfam00395
1036673000237	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1036673000238	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1036673000239	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1036673000240	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1036673000241	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1036673000242	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673000243	Sensor protein DegS; Region: DegS; pfam05384
1036673000244	Histidine kinase; Region: HisKA_3; pfam07730
1036673000245	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1036673000246	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673000247	ATP binding site [chemical binding]; other site
1036673000248	Mg2+ binding site [ion binding]; other site
1036673000249	G-X-G motif; other site
1036673000250	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673000251	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673000252	active site
1036673000253	phosphorylation site [posttranslational modification]
1036673000254	intermolecular recognition site; other site
1036673000255	dimerization interface [polypeptide binding]; other site
1036673000256	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673000257	DNA binding residues [nucleotide binding]
1036673000258	dimerization interface [polypeptide binding]; other site
1036673000259	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1036673000260	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
1036673000261	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1036673000262	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1036673000263	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673000264	Walker A motif; other site
1036673000265	ATP binding site [chemical binding]; other site
1036673000266	ATP binding site [chemical binding]; other site
1036673000267	putative Mg++ binding site [ion binding]; other site
1036673000268	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673000269	nucleotide binding region [chemical binding]; other site
1036673000270	ATP-binding site [chemical binding]; other site
1036673000271	comF family protein; Region: comF; TIGR00201
1036673000272	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036673000273	active site
1036673000274	flagellar operon protein TIGR03826; Region: YvyF
1036673000275	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
1036673000276	FlgN protein; Region: FlgN; pfam05130
1036673000277	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
1036673000278	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1036673000279	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
1036673000280	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1036673000281	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1036673000282	flagellar assembly protein FliW; Provisional; Region: PRK13285
1036673000283	carbon storage regulator; Provisional; Region: PRK01712
1036673000284	flagellin; Provisional; Region: PRK12804
1036673000285	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1036673000286	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1036673000287	flagellin; Provisional; Region: PRK12804
1036673000288	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1036673000289	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1036673000290	flagellin; Provisional; Region: PRK12804
1036673000291	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1036673000292	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1036673000293	flagellin; Provisional; Region: PRK12804
1036673000294	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1036673000295	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1036673000296	FlaG protein; Region: FlaG; pfam03646
1036673000297	flagellar capping protein; Validated; Region: fliD; PRK07737
1036673000298	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
1036673000299	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
1036673000300	Flagellar protein FliS; Region: FliS; cl00654
1036673000301	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1036673000302	DNA-binding site [nucleotide binding]; DNA binding site
1036673000303	RNA-binding motif; other site
1036673000304	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1036673000305	30S subunit binding site; other site
1036673000306	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1036673000307	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1036673000308	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1036673000309	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
1036673000310	nucleotide binding region [chemical binding]; other site
1036673000311	ATP-binding site [chemical binding]; other site
1036673000312	SEC-C motif; Region: SEC-C; pfam02810
1036673000313	peptide chain release factor 2; Provisional; Region: PRK06746
1036673000314	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1036673000315	RF-1 domain; Region: RF-1; pfam00472
1036673000316	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1036673000317	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1036673000318	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1036673000319	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1036673000320	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
1036673000321	oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701
1036673000322	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1036673000323	molybdopterin cofactor binding site; other site
1036673000324	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1036673000325	molybdopterin cofactor binding site; other site
1036673000326	Uncharacterized conserved protein [Function unknown]; Region: COG5609
1036673000327	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1036673000328	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1036673000329	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1036673000330	heterotetramer interface [polypeptide binding]; other site
1036673000331	active site pocket [active]
1036673000332	cleavage site
1036673000333	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
1036673000334	nucleotide binding site [chemical binding]; other site
1036673000335	N-acetyl-L-glutamate binding site [chemical binding]; other site
1036673000336	acetylornithine aminotransferase; Provisional; Region: PRK02627
1036673000337	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036673000338	inhibitor-cofactor binding pocket; inhibition site
1036673000339	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673000340	catalytic residue [active]
1036673000341	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1036673000342	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1036673000343	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1036673000344	argininosuccinate synthase; Provisional; Region: PRK13820
1036673000345	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1036673000346	ANP binding site [chemical binding]; other site
1036673000347	Substrate Binding Site II [chemical binding]; other site
1036673000348	Substrate Binding Site I [chemical binding]; other site
1036673000349	argininosuccinate lyase; Provisional; Region: PRK00855
1036673000350	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1036673000351	active sites [active]
1036673000352	tetramer interface [polypeptide binding]; other site
1036673000353	VanW like protein; Region: VanW; pfam04294
1036673000354	G5 domain; Region: G5; pfam07501
1036673000355	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1036673000356	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673000357	Walker A/P-loop; other site
1036673000358	ATP binding site [chemical binding]; other site
1036673000359	Q-loop/lid; other site
1036673000360	ABC transporter signature motif; other site
1036673000361	Walker B; other site
1036673000362	D-loop; other site
1036673000363	H-loop/switch region; other site
1036673000364	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1036673000365	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1036673000366	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1036673000367	Protein of unknown function (DUF2968); Region: DUF2968; pfam11180
1036673000368	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1036673000369	Peptidase family M23; Region: Peptidase_M23; pfam01551
1036673000370	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1036673000371	C-terminal peptidase (prc); Region: prc; TIGR00225
1036673000372	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1036673000373	protein binding site [polypeptide binding]; other site
1036673000374	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1036673000375	Catalytic dyad [active]
1036673000376	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1036673000377	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1036673000378	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1036673000379	flagellar motor protein MotS; Reviewed; Region: PRK06925
1036673000380	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1036673000381	ligand binding site [chemical binding]; other site
1036673000382	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1036673000383	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1036673000384	excinuclease ABC subunit B; Provisional; Region: PRK05298
1036673000385	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673000386	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673000387	nucleotide binding region [chemical binding]; other site
1036673000388	ATP-binding site [chemical binding]; other site
1036673000389	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1036673000390	UvrB/uvrC motif; Region: UVR; pfam02151
1036673000391	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1036673000392	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1036673000393	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1036673000394	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1036673000395	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673000396	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673000397	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673000398	NAD(P) binding site [chemical binding]; other site
1036673000399	active site
1036673000400	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1036673000401	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1036673000402	MBOAT, membrane-bound O-acyltransferase family; Region: MBOAT; cl00738
1036673000403	hypothetical protein; Validated; Region: PRK07080
1036673000404	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673000405	FG-GAP repeat; Region: FG-GAP; pfam01839
1036673000406	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1036673000407	Peptidase family U32; Region: Peptidase_U32; pfam01136
1036673000408	Collagenase; Region: DUF3656; pfam12392
1036673000409	Peptidase family U32; Region: Peptidase_U32; pfam01136
1036673000410	gliding motility-associated ABC transporter ATP-binding subunit GldA; Region: GldA_ABC_ATP; TIGR03522
1036673000411	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1036673000412	Walker A/P-loop; other site
1036673000413	ATP binding site [chemical binding]; other site
1036673000414	Q-loop/lid; other site
1036673000415	ABC transporter signature motif; other site
1036673000416	Walker B; other site
1036673000417	D-loop; other site
1036673000418	H-loop/switch region; other site
1036673000419	gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518
1036673000420	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1036673000421	Domain of unknown function (DUF4340); Region: DUF4340; pfam14238
1036673000422	Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120
1036673000423	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1036673000424	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673000425	motif II; other site
1036673000426	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1036673000427	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673000428	MarR family; Region: MarR; pfam01047
1036673000429	Coat F domain; Region: Coat_F; pfam07875
1036673000430	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1036673000431	PcrB family; Region: PcrB; pfam01884
1036673000432	PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812
1036673000433	substrate binding site [chemical binding]; other site
1036673000434	putative active site [active]
1036673000435	dimer interface [polypeptide binding]; other site
1036673000436	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1036673000437	Part of AAA domain; Region: AAA_19; pfam13245
1036673000438	Family description; Region: UvrD_C_2; pfam13538
1036673000439	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1036673000440	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1036673000441	nucleotide binding pocket [chemical binding]; other site
1036673000442	K-X-D-G motif; other site
1036673000443	catalytic site [active]
1036673000444	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1036673000445	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1036673000446	Dimer interface [polypeptide binding]; other site
1036673000447	BRCT sequence motif; other site
1036673000448	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
1036673000449	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
1036673000450	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1036673000451	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1036673000452	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1036673000453	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1036673000454	Walker A/P-loop; other site
1036673000455	ATP binding site [chemical binding]; other site
1036673000456	Q-loop/lid; other site
1036673000457	ABC transporter signature motif; other site
1036673000458	Walker B; other site
1036673000459	D-loop; other site
1036673000460	H-loop/switch region; other site
1036673000461	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1036673000462	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1036673000463	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1036673000464	Hpr binding site; other site
1036673000465	active site
1036673000466	homohexamer subunit interaction site [polypeptide binding]; other site
1036673000467	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1036673000468	pyrophosphatase PpaX; Provisional; Region: PRK13288
1036673000469	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673000470	motif II; other site
1036673000471	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1036673000472	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1036673000473	trimer interface [polypeptide binding]; other site
1036673000474	active site
1036673000475	substrate binding site [chemical binding]; other site
1036673000476	CoA binding site [chemical binding]; other site
1036673000477	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
1036673000478	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1036673000479	dimer interface [polypeptide binding]; other site
1036673000480	motif 1; other site
1036673000481	active site
1036673000482	motif 2; other site
1036673000483	motif 3; other site
1036673000484	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
1036673000485	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
1036673000486	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1036673000487	histidinol dehydrogenase; Region: hisD; TIGR00069
1036673000488	NAD binding site [chemical binding]; other site
1036673000489	dimerization interface [polypeptide binding]; other site
1036673000490	product binding site; other site
1036673000491	substrate binding site [chemical binding]; other site
1036673000492	zinc binding site [ion binding]; other site
1036673000493	catalytic residues [active]
1036673000494	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1036673000495	putative active site pocket [active]
1036673000496	4-fold oligomerization interface [polypeptide binding]; other site
1036673000497	metal binding residues [ion binding]; metal-binding site
1036673000498	3-fold/trimer interface [polypeptide binding]; other site
1036673000499	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
1036673000500	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1036673000501	putative active site [active]
1036673000502	oxyanion strand; other site
1036673000503	catalytic triad [active]
1036673000504	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1036673000505	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1036673000506	substrate binding site [chemical binding]; other site
1036673000507	glutamase interaction surface [polypeptide binding]; other site
1036673000508	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
1036673000509	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1036673000510	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1036673000511	metal binding site [ion binding]; metal-binding site
1036673000512	histidinol-phosphatase; Provisional; Region: PRK07328
1036673000513	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
1036673000514	active site
1036673000515	dimer interface [polypeptide binding]; other site
1036673000516	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1036673000517	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1036673000518	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036673000519	active site
1036673000520	TPR repeat; Region: TPR_11; pfam13414
1036673000521	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1036673000522	TPR motif; other site
1036673000523	binding surface
1036673000524	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1036673000525	TPR motif; other site
1036673000526	binding surface
1036673000527	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1036673000528	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036673000529	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036673000530	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1036673000531	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1036673000532	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1036673000533	active site
1036673000534	Zn binding site [ion binding]; other site
1036673000535	Putative glycoside hydrolase xylanase; Region: Xylanase; pfam13201
1036673000536	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673000537	Interdomain contacts; other site
1036673000538	Cytokine receptor motif; other site
1036673000539	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1036673000540	active site
1036673000541	catalytic triad [active]
1036673000542	oxyanion hole [active]
1036673000543	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673000544	Interdomain contacts; other site
1036673000545	S-layer homology domain; Region: SLH; pfam00395
1036673000546	S-layer homology domain; Region: SLH; pfam00395
1036673000547	S-layer homology domain; Region: SLH; pfam00395
1036673000548	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1036673000549	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1036673000550	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
1036673000551	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1036673000552	AAA domain; Region: AAA_33; pfam13671
1036673000553	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1036673000554	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
1036673000555	phosphate binding site [ion binding]; other site
1036673000556	putative substrate binding pocket [chemical binding]; other site
1036673000557	dimer interface [polypeptide binding]; other site
1036673000558	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1036673000559	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1036673000560	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1036673000561	regulatory phosphorylation site [posttranslational modification]; other site
1036673000562	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673000563	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673000564	Bacterial Ig-like domain; Region: Big_5; pfam13205
1036673000565	Clp protease; Region: CLP_protease; pfam00574
1036673000566	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1036673000567	oligomer interface [polypeptide binding]; other site
1036673000568	active site residues [active]
1036673000569	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1036673000570	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1036673000571	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1036673000572	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1036673000573	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1036673000574	Phosphoglycerate kinase; Region: PGK; pfam00162
1036673000575	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1036673000576	substrate binding site [chemical binding]; other site
1036673000577	hinge regions; other site
1036673000578	ADP binding site [chemical binding]; other site
1036673000579	catalytic site [active]
1036673000580	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1036673000581	triosephosphate isomerase; Provisional; Region: PRK14565
1036673000582	substrate binding site [chemical binding]; other site
1036673000583	dimer interface [polypeptide binding]; other site
1036673000584	catalytic triad [active]
1036673000585	phosphoglyceromutase; Provisional; Region: PRK05434
1036673000586	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1036673000587	enolase; Provisional; Region: eno; PRK00077
1036673000588	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1036673000589	dimer interface [polypeptide binding]; other site
1036673000590	metal binding site [ion binding]; metal-binding site
1036673000591	substrate binding pocket [chemical binding]; other site
1036673000592	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
1036673000593	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
1036673000594	Esterase/lipase [General function prediction only]; Region: COG1647
1036673000595	Alpha/beta hydrolase of unknown function (DUF1057); Region: DUF1057; pfam06342
1036673000596	ribonuclease R; Region: RNase_R; TIGR02063
1036673000597	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1036673000598	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1036673000599	RNB domain; Region: RNB; pfam00773
1036673000600	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1036673000601	RNA binding site [nucleotide binding]; other site
1036673000602	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1036673000603	SmpB-tmRNA interface; other site
1036673000604	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1036673000605	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1036673000606	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673000607	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673000608	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673000609	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1036673000610	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
1036673000611	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
1036673000612	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036673000613	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673000614	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
1036673000615	putative hydrophobic ligand binding site [chemical binding]; other site
1036673000616	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1036673000617	putative transporter; Provisional; Region: PRK11021
1036673000618	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673000619	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673000620	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673000621	dimerization interface [polypeptide binding]; other site
1036673000622	Imelysin; Region: Peptidase_M75; pfam09375
1036673000623	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1036673000624	High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672
1036673000625	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
1036673000626	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1036673000627	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1036673000628	putative active site [active]
1036673000629	catalytic triad [active]
1036673000630	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
1036673000631	putative integrin binding motif; other site
1036673000632	PA/protease domain interface [polypeptide binding]; other site
1036673000633	Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474
1036673000634	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
1036673000635	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673000636	Interdomain contacts; other site
1036673000637	GH18 domain of Chitinase D (ChiD).  ChiD, a chitinase found in Bacillus circulans, hydrolyzes the 1,4-beta-linkages of N-acetylglucosamine in chitin and chitodextrins.  The domain architecture of ChiD includes a catalytic glycosyl hydrolase family 18; Region: GH18_chitinase_D-like; cd02871
1036673000638	Glycosyl hydrolases family 18; Region: Glyco_hydro_18; pfam00704
1036673000639	putative active site [active]
1036673000640	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1036673000641	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1036673000642	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1036673000643	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1036673000644	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1036673000645	CAT RNA binding domain; Region: CAT_RBD; smart01061
1036673000646	PRD domain; Region: PRD; pfam00874
1036673000647	PRD domain; Region: PRD; pfam00874
1036673000648	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
1036673000649	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1036673000650	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1036673000651	active site turn [active]
1036673000652	phosphorylation site [posttranslational modification]
1036673000653	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1036673000654	HPr interaction site; other site
1036673000655	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1036673000656	active site
1036673000657	phosphorylation site [posttranslational modification]
1036673000658	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1036673000659	dimerization domain swap beta strand [polypeptide binding]; other site
1036673000660	regulatory protein interface [polypeptide binding]; other site
1036673000661	active site
1036673000662	regulatory phosphorylation site [posttranslational modification]; other site
1036673000663	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1036673000664	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1036673000665	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1036673000666	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1036673000667	General stress protein [General function prediction only]; Region: GsiB; COG3729
1036673000668	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673000669	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673000670	metal binding site [ion binding]; metal-binding site
1036673000671	active site
1036673000672	I-site; other site
1036673000673	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1036673000674	Hpr(Ser) kinase/phosphatase; Region: hpr-ser; TIGR00679
1036673000675	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1036673000676	Hpr binding site; other site
1036673000677	active site
1036673000678	homohexamer subunit interaction site [polypeptide binding]; other site
1036673000679	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1036673000680	extended (e) SDRs; Region: SDR_e; cd08946
1036673000681	NAD(P) binding site [chemical binding]; other site
1036673000682	active site
1036673000683	substrate binding site [chemical binding]; other site
1036673000684	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
1036673000685	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1036673000686	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673000687	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673000688	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1036673000689	active site
1036673000690	metal-dependent hydrolase; Provisional; Region: PRK13291
1036673000691	DinB superfamily; Region: DinB_2; pfam12867
1036673000692	short chain dehydrogenase; Provisional; Region: PRK06197
1036673000693	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
1036673000694	putative NAD(P) binding site [chemical binding]; other site
1036673000695	active site
1036673000696	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1036673000697	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1036673000698	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1036673000699	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1036673000700	GIY-YIG motif/motif A; other site
1036673000701	active site
1036673000702	catalytic site [active]
1036673000703	putative DNA binding site [nucleotide binding]; other site
1036673000704	metal binding site [ion binding]; metal-binding site
1036673000705	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1036673000706	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1036673000707	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
1036673000708	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1036673000709	Cold-inducible protein YdjO; Region: YdjO; pfam14169
1036673000710	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1036673000711	DNA-binding site [nucleotide binding]; DNA binding site
1036673000712	RNA-binding motif; other site
1036673000713	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1036673000714	dinuclear metal binding motif [ion binding]; other site
1036673000715	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
1036673000716	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673000717	Coenzyme A binding pocket [chemical binding]; other site
1036673000718	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673000719	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673000720	dimerization interface [polypeptide binding]; other site
1036673000721	Histidine kinase; Region: His_kinase; pfam06580
1036673000722	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673000723	ATP binding site [chemical binding]; other site
1036673000724	Mg2+ binding site [ion binding]; other site
1036673000725	G-X-G motif; other site
1036673000726	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673000727	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673000728	active site
1036673000729	phosphorylation site [posttranslational modification]
1036673000730	intermolecular recognition site; other site
1036673000731	dimerization interface [polypeptide binding]; other site
1036673000732	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673000733	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673000734	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673000735	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1036673000736	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
1036673000737	putative ligand binding site [chemical binding]; other site
1036673000738	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673000739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673000740	dimer interface [polypeptide binding]; other site
1036673000741	conserved gate region; other site
1036673000742	ABC-ATPase subunit interface; other site
1036673000743	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673000744	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673000745	dimer interface [polypeptide binding]; other site
1036673000746	ABC-ATPase subunit interface; other site
1036673000747	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673000748	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673000749	Fn3 associated; Region: Fn3_assoc; pfam13287
1036673000750	Fn3 associated; Region: Fn3_assoc; pfam13287
1036673000751	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1036673000752	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
1036673000753	putative ligand binding site [chemical binding]; other site
1036673000754	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673000755	dimerization interface [polypeptide binding]; other site
1036673000756	putative DNA binding site [nucleotide binding]; other site
1036673000757	putative Zn2+ binding site [ion binding]; other site
1036673000758	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1036673000759	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673000760	Walker A/P-loop; other site
1036673000761	ATP binding site [chemical binding]; other site
1036673000762	Q-loop/lid; other site
1036673000763	ABC transporter signature motif; other site
1036673000764	Walker B; other site
1036673000765	D-loop; other site
1036673000766	H-loop/switch region; other site
1036673000767	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1036673000768	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1036673000769	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673000770	Walker A/P-loop; other site
1036673000771	ATP binding site [chemical binding]; other site
1036673000772	Q-loop/lid; other site
1036673000773	ABC transporter signature motif; other site
1036673000774	Walker B; other site
1036673000775	D-loop; other site
1036673000776	H-loop/switch region; other site
1036673000777	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1036673000778	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1036673000779	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1036673000780	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673000781	dimer interface [polypeptide binding]; other site
1036673000782	conserved gate region; other site
1036673000783	putative PBP binding loops; other site
1036673000784	ABC-ATPase subunit interface; other site
1036673000785	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1036673000786	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673000787	dimer interface [polypeptide binding]; other site
1036673000788	conserved gate region; other site
1036673000789	putative PBP binding loops; other site
1036673000790	ABC-ATPase subunit interface; other site
1036673000791	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1036673000792	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1036673000793	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673000794	S-adenosylmethionine binding site [chemical binding]; other site
1036673000795	Predicted membrane protein (DUF2243); Region: DUF2243; cl01783
1036673000796	GAF domain; Region: GAF; pfam01590
1036673000797	GAF domain; Region: GAF_2; pfam13185
1036673000798	PAS domain S-box; Region: sensory_box; TIGR00229
1036673000799	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673000800	putative active site [active]
1036673000801	heme pocket [chemical binding]; other site
1036673000802	PAS domain S-box; Region: sensory_box; TIGR00229
1036673000803	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673000804	putative active site [active]
1036673000805	heme pocket [chemical binding]; other site
1036673000806	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673000807	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1036673000808	putative active site [active]
1036673000809	heme pocket [chemical binding]; other site
1036673000810	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673000811	putative active site [active]
1036673000812	heme pocket [chemical binding]; other site
1036673000813	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673000814	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673000815	metal binding site [ion binding]; metal-binding site
1036673000816	active site
1036673000817	I-site; other site
1036673000818	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1036673000819	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1036673000820	active site
1036673000821	ATP binding site [chemical binding]; other site
1036673000822	substrate binding site [chemical binding]; other site
1036673000823	activation loop (A-loop); other site
1036673000824	S-layer homology domain; Region: SLH; pfam00395
1036673000825	S-layer homology domain; Region: SLH; pfam00395
1036673000826	CAAX protease self-immunity; Region: Abi; pfam02517
1036673000827	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1036673000828	Predicted integral membrane protein [Function unknown]; Region: COG5658
1036673000829	SdpI/YhfL protein family; Region: SdpI; pfam13630
1036673000830	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673000831	putative DNA binding site [nucleotide binding]; other site
1036673000832	putative Zn2+ binding site [ion binding]; other site
1036673000833	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673000834	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673000835	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673000836	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673000837	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673000838	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673000839	active site
1036673000840	catalytic tetrad [active]
1036673000841	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036673000842	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673000843	WHG domain; Region: WHG; pfam13305
1036673000844	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1036673000845	Sulfatase; Region: Sulfatase; pfam00884
1036673000846	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
1036673000847	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
1036673000848	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
1036673000849	active site
1036673000850	P-loop; other site
1036673000851	phosphorylation site [posttranslational modification]
1036673000852	HTH domain; Region: HTH_11; cl17392
1036673000853	HTH domain; Region: HTH_11; pfam08279
1036673000854	PRD domain; Region: PRD; pfam00874
1036673000855	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
1036673000856	active site
1036673000857	P-loop; other site
1036673000858	phosphorylation site [posttranslational modification]
1036673000859	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
1036673000860	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1036673000861	active site
1036673000862	phosphorylation site [posttranslational modification]
1036673000863	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
1036673000864	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1036673000865	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1036673000866	deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353
1036673000867	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036673000868	Zn2+ binding site [ion binding]; other site
1036673000869	Mg2+ binding site [ion binding]; other site
1036673000870	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1036673000871	transglutaminase; Provisional; Region: tgl; PRK03187
1036673000872	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673000873	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1036673000874	active site
1036673000875	metal binding site [ion binding]; metal-binding site
1036673000876	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1036673000877	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673000878	DNA-binding site [nucleotide binding]; DNA binding site
1036673000879	FCD domain; Region: FCD; pfam07729
1036673000880	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1036673000881	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1036673000882	Walker A/P-loop; other site
1036673000883	ATP binding site [chemical binding]; other site
1036673000884	Q-loop/lid; other site
1036673000885	ABC transporter signature motif; other site
1036673000886	Walker B; other site
1036673000887	D-loop; other site
1036673000888	H-loop/switch region; other site
1036673000889	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036673000890	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673000891	putative PBP binding loops; other site
1036673000892	dimer interface [polypeptide binding]; other site
1036673000893	ABC-ATPase subunit interface; other site
1036673000894	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1036673000895	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673000896	membrane-bound complex binding site; other site
1036673000897	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1036673000898	nudix motif; other site
1036673000899	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1036673000900	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673000901	Interdomain contacts; other site
1036673000902	Cytokine receptor motif; other site
1036673000903	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1036673000904	putative metal binding site [ion binding]; other site
1036673000905	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673000906	Interdomain contacts; other site
1036673000907	Cytokine receptor motif; other site
1036673000908	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1036673000909	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673000910	Interdomain contacts; other site
1036673000911	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673000912	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673000913	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673000914	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673000915	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673000916	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673000917	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673000918	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673000919	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673000920	Interdomain contacts; other site
1036673000921	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673000922	Interdomain contacts; other site
1036673000923	Cytokine receptor motif; other site
1036673000924	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1036673000925	catalytic core [active]
1036673000926	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399
1036673000927	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673000928	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1036673000929	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1036673000930	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673000931	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1036673000932	putative active site [active]
1036673000933	heme pocket [chemical binding]; other site
1036673000934	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673000935	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1036673000936	putative active site [active]
1036673000937	heme pocket [chemical binding]; other site
1036673000938	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1036673000939	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673000940	heme pocket [chemical binding]; other site
1036673000941	putative active site [active]
1036673000942	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673000943	putative active site [active]
1036673000944	heme pocket [chemical binding]; other site
1036673000945	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1036673000946	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673000947	putative active site [active]
1036673000948	heme pocket [chemical binding]; other site
1036673000949	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673000950	dimer interface [polypeptide binding]; other site
1036673000951	phosphorylation site [posttranslational modification]
1036673000952	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673000953	ATP binding site [chemical binding]; other site
1036673000954	Mg2+ binding site [ion binding]; other site
1036673000955	G-X-G motif; other site
1036673000956	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1036673000957	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673000958	active site
1036673000959	phosphorylation site [posttranslational modification]
1036673000960	intermolecular recognition site; other site
1036673000961	diacylglycerol glucosyltransferase; Provisional; Region: PRK13609
1036673000962	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1036673000963	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1036673000964	YhfH-like protein; Region: YhfH; pfam14149
1036673000965	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673000966	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673000967	dimer interface [polypeptide binding]; other site
1036673000968	phosphorylation site [posttranslational modification]
1036673000969	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673000970	ATP binding site [chemical binding]; other site
1036673000971	Mg2+ binding site [ion binding]; other site
1036673000972	G-X-G motif; other site
1036673000973	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673000974	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673000975	active site
1036673000976	phosphorylation site [posttranslational modification]
1036673000977	intermolecular recognition site; other site
1036673000978	dimerization interface [polypeptide binding]; other site
1036673000979	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1036673000980	Histidine kinase; Region: HisKA_3; pfam07730
1036673000981	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1036673000982	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673000983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673000984	active site
1036673000985	phosphorylation site [posttranslational modification]
1036673000986	intermolecular recognition site; other site
1036673000987	dimerization interface [polypeptide binding]; other site
1036673000988	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673000989	DNA binding residues [nucleotide binding]
1036673000990	dimerization interface [polypeptide binding]; other site
1036673000991	Predicted membrane protein [Function unknown]; Region: COG4818
1036673000992	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673000993	dimer interface [polypeptide binding]; other site
1036673000994	phosphorylation site [posttranslational modification]
1036673000995	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673000996	ATP binding site [chemical binding]; other site
1036673000997	Mg2+ binding site [ion binding]; other site
1036673000998	G-X-G motif; other site
1036673000999	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1036673001000	dimer interface [polypeptide binding]; other site
1036673001001	FMN binding site [chemical binding]; other site
1036673001002	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673001003	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673001004	dimerization interface [polypeptide binding]; other site
1036673001005	Histidine kinase; Region: His_kinase; pfam06580
1036673001006	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673001007	ATP binding site [chemical binding]; other site
1036673001008	Mg2+ binding site [ion binding]; other site
1036673001009	G-X-G motif; other site
1036673001010	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673001011	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673001012	active site
1036673001013	phosphorylation site [posttranslational modification]
1036673001014	intermolecular recognition site; other site
1036673001015	dimerization interface [polypeptide binding]; other site
1036673001016	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673001017	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673001018	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673001019	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1036673001020	EamA-like transporter family; Region: EamA; pfam00892
1036673001021	EamA-like transporter family; Region: EamA; pfam00892
1036673001022	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1036673001023	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673001024	putative substrate translocation pore; other site
1036673001025	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673001026	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673001027	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
1036673001028	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673001029	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1036673001030	Coenzyme A binding pocket [chemical binding]; other site
1036673001031	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
1036673001032	Phage Tail Collar Domain; Region: Collar; pfam07484
1036673001033	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1036673001034	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
1036673001035	Phage Tail Collar Domain; Region: Collar; pfam07484
1036673001036	Microcystin-dependent protein [Function unknown]; Region: MdpB; COG4675
1036673001037	Phage Tail Collar Domain; Region: Collar; pfam07484
1036673001038	Domain of unknown function DUF11; Region: DUF11; pfam01345
1036673001039	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
1036673001040	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1036673001041	S-layer homology domain; Region: SLH; pfam00395
1036673001042	S-layer homology domain; Region: SLH; pfam00395
1036673001043	S-layer homology domain; Region: SLH; pfam00395
1036673001044	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673001045	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673001046	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1036673001047	Old yellow enzyme (OYE)-related FMN binding domain, group 5.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747
1036673001048	putative active site [active]
1036673001049	putative FMN binding site [chemical binding]; other site
1036673001050	putative substrate binding site [chemical binding]; other site
1036673001051	putative catalytic residue [active]
1036673001052	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673001053	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036673001054	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673001055	S-adenosylmethionine binding site [chemical binding]; other site
1036673001056	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1036673001057	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673001058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673001059	dimer interface [polypeptide binding]; other site
1036673001060	conserved gate region; other site
1036673001061	putative PBP binding loops; other site
1036673001062	ABC-ATPase subunit interface; other site
1036673001063	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673001064	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673001065	dimer interface [polypeptide binding]; other site
1036673001066	conserved gate region; other site
1036673001067	ABC-ATPase subunit interface; other site
1036673001068	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673001069	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673001070	putative alpha-glucosidase; Provisional; Region: PRK10658
1036673001071	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1036673001072	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
1036673001073	active site
1036673001074	homotrimer interface [polypeptide binding]; other site
1036673001075	catalytic site [active]
1036673001076	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
1036673001077	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673001078	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1036673001079	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1036673001080	S-layer homology domain; Region: SLH; pfam00395
1036673001081	S-layer homology domain; Region: SLH; pfam00395
1036673001082	Domain of unknown function (DUF1992); Region: DUF1992; cl08096
1036673001083	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1036673001084	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1036673001085	metal ion-dependent adhesion site (MIDAS); other site
1036673001086	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1036673001087	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1036673001088	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673001089	Walker A motif; other site
1036673001090	ATP binding site [chemical binding]; other site
1036673001091	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1036673001092	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1036673001093	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1036673001094	active site
1036673001095	substrate binding site [chemical binding]; other site
1036673001096	ATP binding site [chemical binding]; other site
1036673001097	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
1036673001098	AAA domain; Region: AAA_31; pfam13614
1036673001099	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1036673001100	Protein of unknown function (DUF1162); Region: DUF1162; pfam06650
1036673001101	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1036673001102	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1036673001103	Walker A motif; other site
1036673001104	ATP binding site [chemical binding]; other site
1036673001105	Walker B motif; other site
1036673001106	S-layer homology domain; Region: SLH; pfam00395
1036673001107	S-layer homology domain; Region: SLH; pfam00395
1036673001108	putative catalytic domain of glycoside hydrolase family 119 (GH119); Region: GH119_BcIgtZ-like; cd11663
1036673001109	putative active site [active]
1036673001110	catalytic site [active]
1036673001111	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673001112	Interdomain contacts; other site
1036673001113	Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423
1036673001114	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
1036673001115	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
1036673001116	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1036673001117	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
1036673001118	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1036673001119	DctM-like transporters; Region: DctM; pfam06808
1036673001120	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1036673001121	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1036673001122	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1036673001123	Cache domain; Region: Cache_1; pfam02743
1036673001124	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673001125	dimerization interface [polypeptide binding]; other site
1036673001126	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673001127	Histidine kinase; Region: His_kinase; pfam06580
1036673001128	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673001129	ATP binding site [chemical binding]; other site
1036673001130	Mg2+ binding site [ion binding]; other site
1036673001131	G-X-G motif; other site
1036673001132	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673001133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673001134	active site
1036673001135	phosphorylation site [posttranslational modification]
1036673001136	intermolecular recognition site; other site
1036673001137	dimerization interface [polypeptide binding]; other site
1036673001138	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673001139	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673001140	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673001141	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1036673001142	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673001143	active site
1036673001144	phosphorylation site [posttranslational modification]
1036673001145	intermolecular recognition site; other site
1036673001146	dimerization interface [polypeptide binding]; other site
1036673001147	B12 binding domain; Region: B12-binding_2; pfam02607
1036673001148	B12 binding domain; Region: B12-binding; pfam02310
1036673001149	B12 binding site [chemical binding]; other site
1036673001150	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673001151	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673001152	dimer interface [polypeptide binding]; other site
1036673001153	phosphorylation site [posttranslational modification]
1036673001154	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673001155	ATP binding site [chemical binding]; other site
1036673001156	Mg2+ binding site [ion binding]; other site
1036673001157	G-X-G motif; other site
1036673001158	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673001159	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673001160	active site
1036673001161	phosphorylation site [posttranslational modification]
1036673001162	intermolecular recognition site; other site
1036673001163	dimerization interface [polypeptide binding]; other site
1036673001164	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1036673001165	putative binding surface; other site
1036673001166	active site
1036673001167	Pectate lyase; Region: Pectate_lyase; pfam03211
1036673001168	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1036673001169	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
1036673001170	Pectate lyase; Region: Pec_lyase_C; cl01593
1036673001171	Domain of unknown function (DUF1835); Region: DUF1835; pfam08874
1036673001172	Protein of unknown function; Region: DUF3658; pfam12395
1036673001173	Leucine rich repeat; Region: LRR_8; pfam13855
1036673001174	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1036673001175	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673001176	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673001177	DNA binding residues [nucleotide binding]
1036673001178	SnoaL-like domain; Region: SnoaL_2; pfam12680
1036673001179	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1036673001180	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036673001181	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673001182	Coenzyme A binding pocket [chemical binding]; other site
1036673001183	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1036673001184	dimer interface [polypeptide binding]; other site
1036673001185	FMN binding site [chemical binding]; other site
1036673001186	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1036673001187	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1036673001188	P-loop; other site
1036673001189	Magnesium ion binding site [ion binding]; other site
1036673001190	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1036673001191	Magnesium ion binding site [ion binding]; other site
1036673001192	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1036673001193	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1036673001194	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1036673001195	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673001196	ATP binding site [chemical binding]; other site
1036673001197	putative Mg++ binding site [ion binding]; other site
1036673001198	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673001199	nucleotide binding region [chemical binding]; other site
1036673001200	ATP-binding site [chemical binding]; other site
1036673001201	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1036673001202	HRDC domain; Region: HRDC; pfam00570
1036673001203	Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341
1036673001204	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
1036673001205	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cd06222
1036673001206	active site
1036673001207	RNA/DNA hybrid binding site [nucleotide binding]; other site
1036673001208	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1036673001209	putative hydrolase; Provisional; Region: PRK11460
1036673001210	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1036673001211	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1036673001212	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673001213	Zn binding site [ion binding]; other site
1036673001214	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1036673001215	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673001216	Zn binding site [ion binding]; other site
1036673001217	DoxX; Region: DoxX; pfam07681
1036673001218	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673001219	MarR family; Region: MarR; pfam01047
1036673001220	MarR family; Region: MarR_2; cl17246
1036673001221	Predicted transcriptional regulator [Transcription]; Region: COG2378
1036673001222	HTH domain; Region: HTH_11; pfam08279
1036673001223	WYL domain; Region: WYL; pfam13280
1036673001224	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1036673001225	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1036673001226	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
1036673001227	Na2 binding site [ion binding]; other site
1036673001228	putative substrate binding site 1 [chemical binding]; other site
1036673001229	Na binding site 1 [ion binding]; other site
1036673001230	putative substrate binding site 2 [chemical binding]; other site
1036673001231	PAS fold; Region: PAS_4; pfam08448
1036673001232	PAS domain S-box; Region: sensory_box; TIGR00229
1036673001233	PAS domain; Region: PAS; smart00091
1036673001234	putative active site [active]
1036673001235	heme pocket [chemical binding]; other site
1036673001236	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673001237	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673001238	metal binding site [ion binding]; metal-binding site
1036673001239	active site
1036673001240	I-site; other site
1036673001241	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673001242	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1036673001243	ThiC-associated domain; Region: ThiC-associated; pfam13667
1036673001244	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1036673001245	ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982
1036673001246	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673001247	Walker A/P-loop; other site
1036673001248	ATP binding site [chemical binding]; other site
1036673001249	Q-loop/lid; other site
1036673001250	ABC transporter signature motif; other site
1036673001251	Walker B; other site
1036673001252	D-loop; other site
1036673001253	H-loop/switch region; other site
1036673001254	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1036673001255	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673001256	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673001257	dimerization interface [polypeptide binding]; other site
1036673001258	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673001259	dimer interface [polypeptide binding]; other site
1036673001260	phosphorylation site [posttranslational modification]
1036673001261	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673001262	ATP binding site [chemical binding]; other site
1036673001263	Mg2+ binding site [ion binding]; other site
1036673001264	G-X-G motif; other site
1036673001265	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673001266	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673001267	active site
1036673001268	phosphorylation site [posttranslational modification]
1036673001269	intermolecular recognition site; other site
1036673001270	dimerization interface [polypeptide binding]; other site
1036673001271	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673001272	DNA binding site [nucleotide binding]
1036673001273	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673001274	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673001275	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673001276	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1036673001277	pyruvate kinase; Provisional; Region: PRK05826
1036673001278	domain interfaces; other site
1036673001279	active site
1036673001280	Protein of unknown function (DUF554); Region: DUF554; pfam04474
1036673001281	seryl-tRNA synthetase; Provisional; Region: PRK05431
1036673001282	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1036673001283	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1036673001284	motif 1; other site
1036673001285	dimer interface [polypeptide binding]; other site
1036673001286	active site
1036673001287	motif 2; other site
1036673001288	motif 3; other site
1036673001289	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673001290	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1036673001291	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673001292	Walker A/P-loop; other site
1036673001293	ATP binding site [chemical binding]; other site
1036673001294	Q-loop/lid; other site
1036673001295	ABC transporter signature motif; other site
1036673001296	Walker B; other site
1036673001297	D-loop; other site
1036673001298	H-loop/switch region; other site
1036673001299	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673001300	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673001301	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1036673001302	Walker A/P-loop; other site
1036673001303	ATP binding site [chemical binding]; other site
1036673001304	Q-loop/lid; other site
1036673001305	ABC transporter signature motif; other site
1036673001306	Walker B; other site
1036673001307	D-loop; other site
1036673001308	H-loop/switch region; other site
1036673001309	Thiamine pyrophosphokinase; Region: TPK; cd07995
1036673001310	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
1036673001311	active site
1036673001312	dimerization interface [polypeptide binding]; other site
1036673001313	thiamine binding site [chemical binding]; other site
1036673001314	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1036673001315	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1036673001316	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932
1036673001317	Virulence factor; Region: Virulence_fact; pfam13769
1036673001318	HEAT repeats; Region: HEAT_2; pfam13646
1036673001319	HEAT repeat; Region: HEAT; pfam02985
1036673001320	HEAT repeats; Region: HEAT_2; pfam13646
1036673001321	E-Z type HEAT repeats; Region: EZ_HEAT; smart00567
1036673001322	DinB superfamily; Region: DinB_2; pfam12867
1036673001323	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1036673001324	Guanylate kinase; Region: Guanylate_kin; pfam00625
1036673001325	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1036673001326	active site
1036673001327	helicase 45; Provisional; Region: PTZ00424
1036673001328	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1036673001329	ATP binding site [chemical binding]; other site
1036673001330	Mg++ binding site [ion binding]; other site
1036673001331	motif III; other site
1036673001332	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673001333	nucleotide binding region [chemical binding]; other site
1036673001334	ATP-binding site [chemical binding]; other site
1036673001335	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1036673001336	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
1036673001337	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1036673001338	Cytochrome c; Region: Cytochrom_C; cl11414
1036673001339	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1036673001340	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1036673001341	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1036673001342	D-pathway; other site
1036673001343	Putative ubiquinol binding site [chemical binding]; other site
1036673001344	Low-spin heme (heme b) binding site [chemical binding]; other site
1036673001345	Putative water exit pathway; other site
1036673001346	Binuclear center (heme o3/CuB) [ion binding]; other site
1036673001347	K-pathway; other site
1036673001348	Putative proton exit pathway; other site
1036673001349	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1036673001350	Subunit I/III interface [polypeptide binding]; other site
1036673001351	Subunit III/IV interface [polypeptide binding]; other site
1036673001352	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
1036673001353	Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; cl09173
1036673001354	Protein of unknown function (DUF420); Region: DUF420; pfam04238
1036673001355	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1036673001356	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1036673001357	Bacterial SH3 domain; Region: SH3_3; pfam08239
1036673001358	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1036673001359	NlpC/P60 family; Region: NLPC_P60; pfam00877
1036673001360	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1036673001361	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1036673001362	catalytic residues [active]
1036673001363	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1036673001364	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
1036673001365	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1036673001366	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1036673001367	putative NAD(P) binding site [chemical binding]; other site
1036673001368	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673001369	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673001370	dimerization interface [polypeptide binding]; other site
1036673001371	putative DNA binding site [nucleotide binding]; other site
1036673001372	putative Zn2+ binding site [ion binding]; other site
1036673001373	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1036673001374	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
1036673001375	FeS/SAM binding site; other site
1036673001376	MOSC domain; Region: MOSC; pfam03473
1036673001377	4-hydroxy-2-oxovalerate aldolase-like, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA_like; cd07944
1036673001378	active site
1036673001379	catalytic residues [active]
1036673001380	metal binding site [ion binding]; metal-binding site
1036673001381	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1036673001382	putative active site [active]
1036673001383	nucleotide binding site [chemical binding]; other site
1036673001384	nudix motif; other site
1036673001385	putative metal binding site [ion binding]; other site
1036673001386	S-layer homology domain; Region: SLH; pfam00395
1036673001387	S-layer homology domain; Region: SLH; pfam00395
1036673001388	S-layer homology domain; Region: SLH; pfam00395
1036673001389	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1036673001390	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1036673001391	S-layer homology domain; Region: SLH; pfam00395
1036673001392	S-layer homology domain; Region: SLH; pfam00395
1036673001393	lysophospholipid transporter LplT; Provisional; Region: PRK11195
1036673001394	bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043
1036673001395	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1036673001396	putative acyl-acceptor binding pocket; other site
1036673001397	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673001398	acyl-activating enzyme (AAE) consensus motif; other site
1036673001399	AMP binding site [chemical binding]; other site
1036673001400	active site
1036673001401	CoA binding site [chemical binding]; other site
1036673001402	HI0933-like protein; Region: HI0933_like; pfam03486
1036673001403	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036673001404	Site-specific recombinase; Region: SpecificRecomb; cl15411
1036673001405	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1036673001406	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1036673001407	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673001408	dimerization interface [polypeptide binding]; other site
1036673001409	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673001410	dimer interface [polypeptide binding]; other site
1036673001411	putative CheW interface [polypeptide binding]; other site
1036673001412	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1036673001413	Domain of unknown function DUF21; Region: DUF21; pfam01595
1036673001414	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1036673001415	Transporter associated domain; Region: CorC_HlyC; smart01091
1036673001416	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1036673001417	Cation efflux family; Region: Cation_efflux; pfam01545
1036673001418	Protein of unknown function (DUF3905); Region: DUF3905; pfam13045
1036673001419	bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191
1036673001420	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1036673001421	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1036673001422	homodimer interface [polypeptide binding]; other site
1036673001423	NAD binding pocket [chemical binding]; other site
1036673001424	ATP binding pocket [chemical binding]; other site
1036673001425	Mg binding site [ion binding]; other site
1036673001426	active-site loop [active]
1036673001427	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1036673001428	dimanganese center [ion binding]; other site
1036673001429	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036673001430	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
1036673001431	inhibitor-cofactor binding pocket; inhibition site
1036673001432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673001433	catalytic residue [active]
1036673001434	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1036673001435	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1036673001436	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673001437	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673001438	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673001439	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673001440	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1036673001441	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1036673001442	minor groove reading motif; other site
1036673001443	helix-hairpin-helix signature motif; other site
1036673001444	substrate binding pocket [chemical binding]; other site
1036673001445	active site
1036673001446	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1036673001447	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1036673001448	DNA binding and oxoG recognition site [nucleotide binding]
1036673001449	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1036673001450	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1036673001451	ligand binding site [chemical binding]; other site
1036673001452	flexible hinge region; other site
1036673001453	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1036673001454	non-specific DNA interactions [nucleotide binding]; other site
1036673001455	DNA binding site [nucleotide binding]
1036673001456	sequence specific DNA binding site [nucleotide binding]; other site
1036673001457	putative cAMP binding site [chemical binding]; other site
1036673001458	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1036673001459	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1036673001460	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1036673001461	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1036673001462	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1036673001463	active site
1036673001464	catalytic residues [active]
1036673001465	Fn3 associated; Region: Fn3_assoc; pfam13287
1036673001466	S-layer homology domain; Region: SLH; pfam00395
1036673001467	S-layer homology domain; Region: SLH; pfam00395
1036673001468	putative acetyltransferase; Provisional; Region: PRK03624
1036673001469	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673001470	Coenzyme A binding pocket [chemical binding]; other site
1036673001471	Protein of unknown function (DUF402); Region: DUF402; cl00979
1036673001472	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1036673001473	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1036673001474	Catalytic site [active]
1036673001475	epoxyqueuosine reductase; Region: TIGR00276
1036673001476	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1036673001477	Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin; Region: ARM; cl02500
1036673001478	protein binding surface [polypeptide binding]; other site
1036673001479	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1036673001480	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
1036673001481	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1036673001482	DNA binding site [nucleotide binding]
1036673001483	active site
1036673001484	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1036673001485	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036673001486	Zn2+ binding site [ion binding]; other site
1036673001487	Mg2+ binding site [ion binding]; other site
1036673001488	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1036673001489	homodecamer interface [polypeptide binding]; other site
1036673001490	GTP cyclohydrolase I; Provisional; Region: PLN03044
1036673001491	active site
1036673001492	putative catalytic site residues [active]
1036673001493	zinc binding site [ion binding]; other site
1036673001494	GTP-CH-I/GFRP interaction surface; other site
1036673001495	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1036673001496	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1036673001497	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1036673001498	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1036673001499	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673001500	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1036673001501	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1036673001502	Bacterial transcriptional regulator; Region: IclR; pfam01614
1036673001503	aconitate hydratase; Validated; Region: PRK09277
1036673001504	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1036673001505	substrate binding site [chemical binding]; other site
1036673001506	ligand binding site [chemical binding]; other site
1036673001507	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1036673001508	substrate binding site [chemical binding]; other site
1036673001509	Putative amidase domain; Region: Amidase_6; pfam12671
1036673001510	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1036673001511	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1036673001512	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1036673001513	putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308
1036673001514	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08594
1036673001515	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1036673001516	NAD binding site [chemical binding]; other site
1036673001517	homotetramer interface [polypeptide binding]; other site
1036673001518	homodimer interface [polypeptide binding]; other site
1036673001519	substrate binding site [chemical binding]; other site
1036673001520	active site
1036673001521	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1036673001522	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1036673001523	active site
1036673001524	dimerization interface [polypeptide binding]; other site
1036673001525	AAA domain; Region: AAA_26; pfam13500
1036673001526	Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109
1036673001527	ADP binding site [chemical binding]; other site
1036673001528	biotin synthase; Validated; Region: PRK06256
1036673001529	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673001530	FeS/SAM binding site; other site
1036673001531	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
1036673001532	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1036673001533	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1036673001534	substrate-cofactor binding pocket; other site
1036673001535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673001536	catalytic residue [active]
1036673001537	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1036673001538	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1036673001539	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673001540	S-adenosylmethionine binding site [chemical binding]; other site
1036673001541	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK12481
1036673001542	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
1036673001543	NADP binding site [chemical binding]; other site
1036673001544	homodimer interface [polypeptide binding]; other site
1036673001545	active site
1036673001546	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1036673001547	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1036673001548	substrate binding site [chemical binding]; other site
1036673001549	ATP binding site [chemical binding]; other site
1036673001550	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1036673001551	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1036673001552	active site
1036673001553	intersubunit interface [polypeptide binding]; other site
1036673001554	catalytic residue [active]
1036673001555	Glutamate synthase domain 1 [Amino acid transport and metabolism]; Region: GltB; COG0067
1036673001556	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1036673001557	active site
1036673001558	dimer interface [polypeptide binding]; other site
1036673001559	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1036673001560	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1036673001561	Conserved region in glutamate synthase; Region: Glu_synthase; pfam01645
1036673001562	active site
1036673001563	FMN binding site [chemical binding]; other site
1036673001564	substrate binding site [chemical binding]; other site
1036673001565	3Fe-4S cluster binding site [ion binding]; other site
1036673001566	GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS),  in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cd00504
1036673001567	domain_subunit interface; other site
1036673001568	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389
1036673001569	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036673001570	inhibitor-cofactor binding pocket; inhibition site
1036673001571	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673001572	catalytic residue [active]
1036673001573	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1036673001574	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1036673001575	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1036673001576	ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267
1036673001577	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1036673001578	Walker A/P-loop; other site
1036673001579	ATP binding site [chemical binding]; other site
1036673001580	Q-loop/lid; other site
1036673001581	ABC transporter signature motif; other site
1036673001582	Walker B; other site
1036673001583	D-loop; other site
1036673001584	H-loop/switch region; other site
1036673001585	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1036673001586	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1036673001587	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1036673001588	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673001589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673001590	active site
1036673001591	phosphorylation site [posttranslational modification]
1036673001592	intermolecular recognition site; other site
1036673001593	dimerization interface [polypeptide binding]; other site
1036673001594	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673001595	DNA binding residues [nucleotide binding]
1036673001596	dimerization interface [polypeptide binding]; other site
1036673001597	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1036673001598	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1036673001599	catalytic triad [active]
1036673001600	glycerate dehydrogenase; Provisional; Region: PRK06487
1036673001601	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
1036673001602	putative ligand binding site [chemical binding]; other site
1036673001603	putative NAD binding site [chemical binding]; other site
1036673001604	catalytic site [active]
1036673001605	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1036673001606	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1036673001607	Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944
1036673001608	NodB motif; other site
1036673001609	active site
1036673001610	catalytic site [active]
1036673001611	Zn binding site [ion binding]; other site
1036673001612	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673001613	MoxR-like ATPases [General function prediction only]; Region: COG0714
1036673001614	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673001615	Walker A motif; other site
1036673001616	ATP binding site [chemical binding]; other site
1036673001617	Walker B motif; other site
1036673001618	arginine finger; other site
1036673001619	Protein of unknown function DUF58; Region: DUF58; pfam01882
1036673001620	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1036673001621	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1036673001622	GMP synthase; Reviewed; Region: guaA; PRK00074
1036673001623	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1036673001624	AMP/PPi binding site [chemical binding]; other site
1036673001625	candidate oxyanion hole; other site
1036673001626	catalytic triad [active]
1036673001627	potential glutamine specificity residues [chemical binding]; other site
1036673001628	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1036673001629	ATP Binding subdomain [chemical binding]; other site
1036673001630	Ligand Binding sites [chemical binding]; other site
1036673001631	Dimerization subdomain; other site
1036673001632	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1036673001633	2-isopropylmalate synthase; Validated; Region: PRK00915
1036673001634	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1036673001635	active site
1036673001636	catalytic residues [active]
1036673001637	metal binding site [ion binding]; metal-binding site
1036673001638	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1036673001639	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
1036673001640	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1036673001641	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673001642	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673001643	ABC transporter; Region: ABC_tran_2; pfam12848
1036673001644	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673001645	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212
1036673001646	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1036673001647	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1036673001648	trimer interface [polypeptide binding]; other site
1036673001649	dimer interface [polypeptide binding]; other site
1036673001650	putative active site [active]
1036673001651	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1036673001652	MPT binding site; other site
1036673001653	trimer interface [polypeptide binding]; other site
1036673001654	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
1036673001655	putative MPT binding site; other site
1036673001656	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1036673001657	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1036673001658	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1036673001659	oligomerisation interface [polypeptide binding]; other site
1036673001660	mobile loop; other site
1036673001661	roof hairpin; other site
1036673001662	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1036673001663	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1036673001664	ring oligomerisation interface [polypeptide binding]; other site
1036673001665	ATP/Mg binding site [chemical binding]; other site
1036673001666	stacking interactions; other site
1036673001667	hinge regions; other site
1036673001668	SNF2 Helicase protein; Region: DUF3670; pfam12419
1036673001669	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1036673001670	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673001671	ATP binding site [chemical binding]; other site
1036673001672	putative Mg++ binding site [ion binding]; other site
1036673001673	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673001674	nucleotide binding region [chemical binding]; other site
1036673001675	ATP-binding site [chemical binding]; other site
1036673001676	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
1036673001677	S-layer homology domain; Region: SLH; pfam00395
1036673001678	S-layer homology domain; Region: SLH; pfam00395
1036673001679	S-layer homology domain; Region: SLH; pfam00395
1036673001680	S-layer homology domain; Region: SLH; pfam00395
1036673001681	S-layer homology domain; Region: SLH; pfam00395
1036673001682	S-layer homology domain; Region: SLH; pfam00395
1036673001683	O-Antigen ligase; Region: Wzy_C; pfam04932
1036673001684	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1036673001685	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1036673001686	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1036673001687	active site
1036673001688	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673001689	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1036673001690	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673001691	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
1036673001692	putative ADP-binding pocket [chemical binding]; other site
1036673001693	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1036673001694	active site 2 [active]
1036673001695	active site 1 [active]
1036673001696	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1036673001697	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1036673001698	active site
1036673001699	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673001700	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1036673001701	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1036673001702	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1036673001703	Ligand binding site; other site
1036673001704	oligomer interface; other site
1036673001705	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1036673001706	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1036673001707	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1036673001708	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1036673001709	Walker A/P-loop; other site
1036673001710	ATP binding site [chemical binding]; other site
1036673001711	Q-loop/lid; other site
1036673001712	ABC transporter signature motif; other site
1036673001713	Walker B; other site
1036673001714	D-loop; other site
1036673001715	H-loop/switch region; other site
1036673001716	C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147
1036673001717	putative carbohydrate binding site [chemical binding]; other site
1036673001718	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673001719	S-adenosylmethionine binding site [chemical binding]; other site
1036673001720	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
1036673001721	KpsF/GutQ family protein; Region: kpsF; TIGR00393
1036673001722	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1036673001723	putative active site [active]
1036673001724	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1036673001725	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1036673001726	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1036673001727	Ligand binding site; other site
1036673001728	Putative Catalytic site; other site
1036673001729	DXD motif; other site
1036673001730	GtrA-like protein; Region: GtrA; pfam04138
1036673001731	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
1036673001732	Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023
1036673001733	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673001734	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1036673001735	alanine racemase; Reviewed; Region: alr; PRK00053
1036673001736	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1036673001737	active site
1036673001738	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1036673001739	dimer interface [polypeptide binding]; other site
1036673001740	substrate binding site [chemical binding]; other site
1036673001741	catalytic residues [active]
1036673001742	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609
1036673001743	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
1036673001744	PemK-like protein; Region: PemK; pfam02452
1036673001745	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1036673001746	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1036673001747	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1036673001748	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1036673001749	RNA binding site [nucleotide binding]; other site
1036673001750	Cyclophilin-like; Region: Cyclophil_like; cl17583
1036673001751	SprT homologues; Region: SprT; cl01182
1036673001752	SprT-like family; Region: SprT-like; pfam10263
1036673001753	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1036673001754	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1036673001755	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1036673001756	dimanganese center [ion binding]; other site
1036673001757	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1036673001758	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
1036673001759	active site
1036673001760	catalytic site [active]
1036673001761	metal binding site [ion binding]; metal-binding site
1036673001762	dimer interface [polypeptide binding]; other site
1036673001763	S-layer homology domain; Region: SLH; pfam00395
1036673001764	S-layer homology domain; Region: SLH; pfam00395
1036673001765	Protein of unknown function (DUF2621); Region: DUF2621; pfam11084
1036673001766	endonuclease IV; Provisional; Region: PRK01060
1036673001767	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1036673001768	AP (apurinic/apyrimidinic) site pocket; other site
1036673001769	DNA interaction; other site
1036673001770	Metal-binding active site; metal-binding site
1036673001771	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
1036673001772	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
1036673001773	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
1036673001774	putative active site [active]
1036673001775	putative substrate binding site [chemical binding]; other site
1036673001776	putative cosubstrate binding site; other site
1036673001777	catalytic site [active]
1036673001778	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1036673001779	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036673001780	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1036673001781	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1036673001782	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1036673001783	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
1036673001784	[2Fe-2S] cluster binding site [ion binding]; other site
1036673001785	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1036673001786	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1036673001787	TPP-binding site [chemical binding]; other site
1036673001788	dimer interface [polypeptide binding]; other site
1036673001789	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1036673001790	PYR/PP interface [polypeptide binding]; other site
1036673001791	dimer interface [polypeptide binding]; other site
1036673001792	TPP binding site [chemical binding]; other site
1036673001793	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
1036673001794	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1036673001795	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1036673001796	PilZ domain; Region: PilZ; pfam07238
1036673001797	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1036673001798	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1036673001799	active site
1036673001800	dimer interface [polypeptide binding]; other site
1036673001801	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1036673001802	dimer interface [polypeptide binding]; other site
1036673001803	active site
1036673001804	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1036673001805	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1036673001806	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1036673001807	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673001808	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673001809	WHG domain; Region: WHG; pfam13305
1036673001810	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
1036673001811	Protein of unknown function (DUF1128); Region: DUF1128; cl11553
1036673001812	Ribosomal protein L35Ae; Region: Ribosomal_L35Ae; cl01033
1036673001813	Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294
1036673001814	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1036673001815	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1036673001816	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1036673001817	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1036673001818	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1036673001819	active site
1036673001820	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1036673001821	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1036673001822	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1036673001823	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1036673001824	Helix-turn-helix domain; Region: HTH_17; pfam12728
1036673001825	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1036673001826	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036673001827	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1036673001828	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
1036673001829	active site
1036673001830	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1036673001831	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1036673001832	putative sugar binding sites [chemical binding]; other site
1036673001833	Q-X-W motif; other site
1036673001834	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1036673001835	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673001836	active site
1036673001837	phosphorylation site [posttranslational modification]
1036673001838	intermolecular recognition site; other site
1036673001839	LytTr DNA-binding domain; Region: LytTR; smart00850
1036673001840	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673001841	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673001842	active site
1036673001843	phosphorylation site [posttranslational modification]
1036673001844	intermolecular recognition site; other site
1036673001845	dimerization interface [polypeptide binding]; other site
1036673001846	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673001847	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1036673001848	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1036673001849	GAF domain; Region: GAF_3; pfam13492
1036673001850	GAF domain; Region: GAF_2; pfam13185
1036673001851	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673001852	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673001853	dimer interface [polypeptide binding]; other site
1036673001854	phosphorylation site [posttranslational modification]
1036673001855	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673001856	ATP binding site [chemical binding]; other site
1036673001857	Mg2+ binding site [ion binding]; other site
1036673001858	G-X-G motif; other site
1036673001859	Domain of unknown function (DUF4303); Region: DUF4303; pfam14136
1036673001860	alpha-galactosidase; Provisional; Region: PRK15076
1036673001861	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
1036673001862	NAD binding site [chemical binding]; other site
1036673001863	sugar binding site [chemical binding]; other site
1036673001864	divalent metal binding site [ion binding]; other site
1036673001865	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1036673001866	dimer interface [polypeptide binding]; other site
1036673001867	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1036673001868	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1036673001869	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1036673001870	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1036673001871	SelR domain; Region: SelR; pfam01641
1036673001872	Domain of unknown function (DUF1904); Region: DUF1904; pfam08921
1036673001873	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1036673001874	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673001875	Coenzyme A binding pocket [chemical binding]; other site
1036673001876	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673001877	dimerization interface [polypeptide binding]; other site
1036673001878	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673001879	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673001880	metal binding site [ion binding]; metal-binding site
1036673001881	active site
1036673001882	I-site; other site
1036673001883	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673001884	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1036673001885	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1036673001886	nudix motif; other site
1036673001887	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1036673001888	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1036673001889	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1036673001890	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1036673001891	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673001892	putative substrate translocation pore; other site
1036673001893	Uncharacterized conserved protein [Function unknown]; Region: COG3339
1036673001894	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1036673001895	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
1036673001896	conserved cys residue [active]
1036673001897	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1036673001898	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1036673001899	metal binding site [ion binding]; metal-binding site
1036673001900	active site
1036673001901	Sulfatase; Region: Sulfatase; pfam00884
1036673001902	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1036673001903	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036673001904	RNA binding surface [nucleotide binding]; other site
1036673001905	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1036673001906	active site
1036673001907	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1036673001908	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1036673001909	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
1036673001910	Walker A/P-loop; other site
1036673001911	ATP binding site [chemical binding]; other site
1036673001912	Q-loop/lid; other site
1036673001913	ABC transporter signature motif; other site
1036673001914	Walker B; other site
1036673001915	D-loop; other site
1036673001916	H-loop/switch region; other site
1036673001917	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1036673001918	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1036673001919	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1036673001920	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
1036673001921	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
1036673001922	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673001923	FeS/SAM binding site; other site
1036673001924	Protein of unknown function (DUF4080); Region: DUF4080; pfam13311
1036673001925	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1036673001926	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
1036673001927	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673001928	S-adenosylmethionine binding site [chemical binding]; other site
1036673001929	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1036673001930	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673001931	FeS/SAM binding site; other site
1036673001932	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
1036673001933	monogalactosyldiacylglycerol synthase; Region: PLN02605
1036673001934	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
1036673001935	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1036673001936	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1036673001937	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1036673001938	active site
1036673001939	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673001940	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
1036673001941	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1036673001942	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
1036673001943	DXD motif; other site
1036673001944	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1036673001945	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1036673001946	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1036673001947	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1036673001948	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1036673001949	23S rRNA binding site [nucleotide binding]; other site
1036673001950	L21 binding site [polypeptide binding]; other site
1036673001951	L13 binding site [polypeptide binding]; other site
1036673001952	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1036673001953	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673001954	active site
1036673001955	metal binding site [ion binding]; metal-binding site
1036673001956	Domain of unknown function (DUF4073); Region: DUF4073; pfam13285
1036673001957	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673001958	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1036673001959	active site
1036673001960	metal binding site [ion binding]; metal-binding site
1036673001961	Domain of unknown function (DUF4073); Region: DUF4073; pfam13285
1036673001962	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
1036673001963	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1036673001964	PYR/PP interface [polypeptide binding]; other site
1036673001965	dimer interface [polypeptide binding]; other site
1036673001966	TPP binding site [chemical binding]; other site
1036673001967	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1036673001968	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1036673001969	TPP-binding site [chemical binding]; other site
1036673001970	dimer interface [polypeptide binding]; other site
1036673001971	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1036673001972	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1036673001973	putative valine binding site [chemical binding]; other site
1036673001974	dimer interface [polypeptide binding]; other site
1036673001975	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1036673001976	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1036673001977	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1036673001978	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1036673001979	2-isopropylmalate synthase; Validated; Region: PRK00915
1036673001980	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1036673001981	active site
1036673001982	catalytic residues [active]
1036673001983	metal binding site [ion binding]; metal-binding site
1036673001984	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1036673001985	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1036673001986	active site
1036673001987	HAMP domain; Region: HAMP; pfam00672
1036673001988	dimerization interface [polypeptide binding]; other site
1036673001989	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673001990	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673001991	dimer interface [polypeptide binding]; other site
1036673001992	putative CheW interface [polypeptide binding]; other site
1036673001993	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673001994	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673001995	acyl-activating enzyme (AAE) consensus motif; other site
1036673001996	AMP binding site [chemical binding]; other site
1036673001997	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673001998	thioester reductase domain; Region: Thioester-redct; TIGR01746
1036673001999	extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235
1036673002000	putative NAD(P) binding site [chemical binding]; other site
1036673002001	active site
1036673002002	putative substrate binding site [chemical binding]; other site
1036673002003	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
1036673002004	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1036673002005	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673002006	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673002007	homodimer interface [polypeptide binding]; other site
1036673002008	catalytic residue [active]
1036673002009	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1036673002010	tartrate dehydrogenase; Region: TTC; TIGR02089
1036673002011	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1036673002012	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
1036673002013	dimer interface [polypeptide binding]; other site
1036673002014	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1036673002015	catalytic triad [active]
1036673002016	peroxidatic and resolving cysteines [active]
1036673002017	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1036673002018	lipoyl attachment site [posttranslational modification]; other site
1036673002019	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1036673002020	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1036673002021	KTSC domain; Region: KTSC; pfam13619
1036673002022	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1036673002023	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
1036673002024	active site
1036673002025	Substrate binding site; other site
1036673002026	Mg++ binding site; other site
1036673002027	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1036673002028	putative trimer interface [polypeptide binding]; other site
1036673002029	putative CoA binding site [chemical binding]; other site
1036673002030	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1036673002031	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
1036673002032	active site
1036673002033	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
1036673002034	substrate binding site [chemical binding]; other site
1036673002035	metal binding site [ion binding]; metal-binding site
1036673002036	Uncharacterized conserved protein [Function unknown]; Region: COG1543
1036673002037	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
1036673002038	active site
1036673002039	substrate binding site [chemical binding]; other site
1036673002040	catalytic site [active]
1036673002041	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
1036673002042	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673002043	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1036673002044	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
1036673002045	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
1036673002046	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673002047	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1036673002048	DinB superfamily; Region: DinB_2; pfam12867
1036673002049	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
1036673002050	CGNR zinc finger; Region: zf-CGNR; pfam11706
1036673002051	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
1036673002052	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673002053	active site
1036673002054	catalytic tetrad [active]
1036673002055	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1036673002056	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1036673002057	interface (dimer of trimers) [polypeptide binding]; other site
1036673002058	Substrate-binding/catalytic site; other site
1036673002059	Zn-binding sites [ion binding]; other site
1036673002060	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673002061	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673002062	PAS domain S-box; Region: sensory_box; TIGR00229
1036673002063	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673002064	putative active site [active]
1036673002065	heme pocket [chemical binding]; other site
1036673002066	PAS fold; Region: PAS_3; pfam08447
1036673002067	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
1036673002068	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1036673002069	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673002070	putative active site [active]
1036673002071	heme pocket [chemical binding]; other site
1036673002072	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673002073	dimer interface [polypeptide binding]; other site
1036673002074	phosphorylation site [posttranslational modification]
1036673002075	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673002076	ATP binding site [chemical binding]; other site
1036673002077	Mg2+ binding site [ion binding]; other site
1036673002078	G-X-G motif; other site
1036673002079	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1036673002080	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
1036673002081	Moco binding site; other site
1036673002082	metal coordination site [ion binding]; other site
1036673002083	Predicted transcriptional regulator [Transcription]; Region: COG2378
1036673002084	HTH domain; Region: HTH_11; pfam08279
1036673002085	WYL domain; Region: WYL; pfam13280
1036673002086	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140
1036673002087	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1036673002088	conserved cys residue [active]
1036673002089	Major royal jelly protein; Region: MRJP; pfam03022
1036673002090	Predicted transcriptional regulators [Transcription]; Region: COG1695
1036673002091	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1036673002092	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1036673002093	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1036673002094	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1036673002095	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1036673002096	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1036673002097	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673002098	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673002099	dimer interface [polypeptide binding]; other site
1036673002100	putative CheW interface [polypeptide binding]; other site
1036673002101	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1036673002102	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1036673002103	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1036673002104	ligand binding site [chemical binding]; other site
1036673002105	flexible hinge region; other site
1036673002106	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1036673002107	Protein of unknown function, DUF606; Region: DUF606; pfam04657
1036673002108	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673002109	Coenzyme A binding pocket [chemical binding]; other site
1036673002110	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673002111	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673002112	dimer interface [polypeptide binding]; other site
1036673002113	phosphorylation site [posttranslational modification]
1036673002114	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673002115	ATP binding site [chemical binding]; other site
1036673002116	Mg2+ binding site [ion binding]; other site
1036673002117	G-X-G motif; other site
1036673002118	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673002119	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673002120	active site
1036673002121	phosphorylation site [posttranslational modification]
1036673002122	intermolecular recognition site; other site
1036673002123	dimerization interface [polypeptide binding]; other site
1036673002124	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673002125	DNA binding site [nucleotide binding]
1036673002126	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
1036673002127	putative metal binding residues [ion binding]; other site
1036673002128	signature motif; other site
1036673002129	dimer interface [polypeptide binding]; other site
1036673002130	active site
1036673002131	polyP binding site; other site
1036673002132	substrate binding site [chemical binding]; other site
1036673002133	acceptor-phosphate pocket; other site
1036673002134	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
1036673002135	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
1036673002136	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1036673002137	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673002138	GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472
1036673002139	active site
1036673002140	oxyanion hole [active]
1036673002141	catalytic triad [active]
1036673002142	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
1036673002143	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673002144	putative substrate translocation pore; other site
1036673002145	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673002146	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673002147	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673002148	active site
1036673002149	phosphorylation site [posttranslational modification]
1036673002150	intermolecular recognition site; other site
1036673002151	dimerization interface [polypeptide binding]; other site
1036673002152	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673002153	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673002154	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673002155	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673002156	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673002157	dimerization interface [polypeptide binding]; other site
1036673002158	Histidine kinase; Region: His_kinase; pfam06580
1036673002159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673002160	ATP binding site [chemical binding]; other site
1036673002161	Mg2+ binding site [ion binding]; other site
1036673002162	G-X-G motif; other site
1036673002163	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1036673002164	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1036673002165	ligand binding site [chemical binding]; other site
1036673002166	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1036673002167	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1036673002168	DNA binding residues [nucleotide binding]
1036673002169	dimer interface [polypeptide binding]; other site
1036673002170	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036673002171	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673002172	S-adenosylmethionine binding site [chemical binding]; other site
1036673002173	GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009
1036673002174	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1036673002175	dimer interface [polypeptide binding]; other site
1036673002176	ADP-ribose binding site [chemical binding]; other site
1036673002177	active site
1036673002178	nudix motif; other site
1036673002179	metal binding site [ion binding]; metal-binding site
1036673002180	IDEAL domain; Region: IDEAL; pfam08858
1036673002181	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1036673002182	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1036673002183	putative active site [active]
1036673002184	putative FMN binding site [chemical binding]; other site
1036673002185	putative substrate binding site [chemical binding]; other site
1036673002186	putative catalytic residue [active]
1036673002187	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673002188	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673002189	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673002190	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673002191	dimerization interface [polypeptide binding]; other site
1036673002192	Histidine kinase; Region: His_kinase; pfam06580
1036673002193	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673002194	ATP binding site [chemical binding]; other site
1036673002195	Mg2+ binding site [ion binding]; other site
1036673002196	G-X-G motif; other site
1036673002197	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673002198	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673002199	active site
1036673002200	phosphorylation site [posttranslational modification]
1036673002201	intermolecular recognition site; other site
1036673002202	dimerization interface [polypeptide binding]; other site
1036673002203	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673002204	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673002205	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1036673002206	GntP family permease; Region: GntP_permease; pfam02447
1036673002207	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
1036673002208	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1036673002209	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1036673002210	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1036673002211	N- and C-terminal domain interface [polypeptide binding]; other site
1036673002212	active site
1036673002213	catalytic site [active]
1036673002214	metal binding site [ion binding]; metal-binding site
1036673002215	carbohydrate binding site [chemical binding]; other site
1036673002216	ATP binding site [chemical binding]; other site
1036673002217	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1036673002218	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1036673002219	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1036673002220	NAD binding site [chemical binding]; other site
1036673002221	catalytic Zn binding site [ion binding]; other site
1036673002222	structural Zn binding site [ion binding]; other site
1036673002223	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1036673002224	Coat F domain; Region: Coat_F; pfam07875
1036673002225	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1036673002226	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1036673002227	AsnC family; Region: AsnC_trans_reg; pfam01037
1036673002228	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
1036673002229	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1036673002230	active site
1036673002231	putative substrate binding pocket [chemical binding]; other site
1036673002232	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673002233	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1036673002234	TM-ABC transporter signature motif; other site
1036673002235	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673002236	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1036673002237	TM-ABC transporter signature motif; other site
1036673002238	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1036673002239	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1036673002240	Walker A/P-loop; other site
1036673002241	ATP binding site [chemical binding]; other site
1036673002242	Q-loop/lid; other site
1036673002243	ABC transporter signature motif; other site
1036673002244	Walker B; other site
1036673002245	D-loop; other site
1036673002246	H-loop/switch region; other site
1036673002247	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1036673002248	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1036673002249	Periplasmic binding component of a family of basic membrane lipoproteins from Borrelia and various putative lipoproteins from other bacteria; Region: PBP1_BmpA_like; cd06304
1036673002250	ligand binding site [chemical binding]; other site
1036673002251	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1036673002252	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1036673002253	[2Fe-2S] cluster binding site [ion binding]; other site
1036673002254	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1036673002255	hydrophobic ligand binding site; other site
1036673002256	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673002257	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673002258	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1036673002259	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
1036673002260	Protein of unknown function (DUF418); Region: DUF418; cl12135
1036673002261	PhoD-like phosphatase; Region: PhoD; pfam09423
1036673002262	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1036673002263	putative active site [active]
1036673002264	putative metal binding site [ion binding]; other site
1036673002265	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
1036673002266	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1036673002267	classical (c) SDRs; Region: SDR_c; cd05233
1036673002268	NAD(P) binding site [chemical binding]; other site
1036673002269	active site
1036673002270	CAAX protease self-immunity; Region: Abi; pfam02517
1036673002271	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1036673002272	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673002273	DNA-binding site [nucleotide binding]; DNA binding site
1036673002274	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673002275	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673002276	homodimer interface [polypeptide binding]; other site
1036673002277	catalytic residue [active]
1036673002278	Lysine efflux permease [General function prediction only]; Region: COG1279
1036673002279	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1036673002280	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
1036673002281	putative [4Fe-4S] binding site [ion binding]; other site
1036673002282	putative molybdopterin cofactor binding site [chemical binding]; other site
1036673002283	The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786
1036673002284	putative molybdopterin cofactor binding site; other site
1036673002285	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673002286	dimer interface [polypeptide binding]; other site
1036673002287	putative CheW interface [polypeptide binding]; other site
1036673002288	amino acid transporter; Region: 2A0306; TIGR00909
1036673002289	urea carboxylase-associated protein 2; Region: urea_degr_2; TIGR03425
1036673002290	urea carboxylase-associated protein 1; Region: urea_degr_1; TIGR03424
1036673002291	Domain of unknown function (DUF1989); Region: DUF1989; pfam09347
1036673002292	urea carboxylase; Region: urea_carbox; TIGR02712
1036673002293	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1036673002294	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1036673002295	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
1036673002296	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
1036673002297	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1036673002298	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1036673002299	carboxyltransferase (CT) interaction site; other site
1036673002300	biotinylation site [posttranslational modification]; other site
1036673002301	allophanate hydrolase; Provisional; Region: PRK08186
1036673002302	Amidase; Region: Amidase; cl11426
1036673002303	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673002304	Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223
1036673002305	putative substrate translocation pore; other site
1036673002306	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1036673002307	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036673002308	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1036673002309	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1036673002310	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1036673002311	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1036673002312	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1036673002313	molybdopterin cofactor binding site; other site
1036673002314	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
1036673002315	molybdopterin cofactor binding site; other site
1036673002316	Sulfatase; Region: Sulfatase; pfam00884
1036673002317	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673002318	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1036673002319	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1036673002320	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1036673002321	Histidine kinase; Region: HisKA_3; pfam07730
1036673002322	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1036673002323	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1036673002324	Aspartase; Region: Aspartase; cd01357
1036673002325	active sites [active]
1036673002326	tetramer interface [polypeptide binding]; other site
1036673002327	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1036673002328	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1036673002329	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1036673002330	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1036673002331	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1036673002332	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673002333	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673002334	ATP binding site [chemical binding]; other site
1036673002335	G-X-G motif; other site
1036673002336	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673002337	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673002338	active site
1036673002339	phosphorylation site [posttranslational modification]
1036673002340	intermolecular recognition site; other site
1036673002341	dimerization interface [polypeptide binding]; other site
1036673002342	YcbB domain; Region: YcbB; pfam08664
1036673002343	Amb_all domain; Region: Amb_all; smart00656
1036673002344	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673002345	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673002346	dimer interface [polypeptide binding]; other site
1036673002347	conserved gate region; other site
1036673002348	ABC-ATPase subunit interface; other site
1036673002349	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673002350	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673002351	dimer interface [polypeptide binding]; other site
1036673002352	conserved gate region; other site
1036673002353	putative PBP binding loops; other site
1036673002354	ABC-ATPase subunit interface; other site
1036673002355	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673002356	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1036673002357	Sodium Bile acid symporter family; Region: SBF; cl17470
1036673002358	MAEBL; Provisional; Region: PTZ00121
1036673002359	S-layer homology domain; Region: SLH; pfam00395
1036673002360	S-layer homology domain; Region: SLH; pfam00395
1036673002361	S-layer homology domain; Region: SLH; pfam00395
1036673002362	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1036673002363	Spore germination protein; Region: Spore_permease; cl17796
1036673002364	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673002365	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673002366	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673002367	YCII-related domain; Region: YCII; cl00999
1036673002368	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1036673002369	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
1036673002370	putative 2-aminoethylphosphonate ABC transporter, ATP-binding protein; Region: PhnT2; TIGR03265
1036673002371	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673002372	Walker A/P-loop; other site
1036673002373	ATP binding site [chemical binding]; other site
1036673002374	Q-loop/lid; other site
1036673002375	ABC transporter signature motif; other site
1036673002376	Walker B; other site
1036673002377	D-loop; other site
1036673002378	H-loop/switch region; other site
1036673002379	TOBE domain; Region: TOBE_2; pfam08402
1036673002380	putative 2-aminoethylphosphonate ABC transporter, permease protein; Region: PhnU2; TIGR03262
1036673002381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673002382	dimer interface [polypeptide binding]; other site
1036673002383	conserved gate region; other site
1036673002384	putative PBP binding loops; other site
1036673002385	ABC-ATPase subunit interface; other site
1036673002386	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673002387	dimer interface [polypeptide binding]; other site
1036673002388	conserved gate region; other site
1036673002389	putative PBP binding loops; other site
1036673002390	ABC-ATPase subunit interface; other site
1036673002391	phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478
1036673002392	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673002393	motif II; other site
1036673002394	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1036673002395	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1036673002396	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036673002397	catalytic residue [active]
1036673002398	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673002399	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
1036673002400	NAD(P) binding site [chemical binding]; other site
1036673002401	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1036673002402	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1036673002403	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1036673002404	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
1036673002405	flagellar motor protein MotA; Validated; Region: PRK08124
1036673002406	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1036673002407	flagellar motor protein MotB; Reviewed; Region: motB; PRK07734
1036673002408	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1036673002409	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1036673002410	ligand binding site [chemical binding]; other site
1036673002411	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
1036673002412	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673002413	Phytase; Region: Phytase; cl17685
1036673002414	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
1036673002415	putative active site [active]
1036673002416	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1036673002417	metal ion-dependent adhesion site (MIDAS); other site
1036673002418	Tubulin like; Region: Tubulin_2; pfam13809
1036673002419	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1036673002420	metal ion-dependent adhesion site (MIDAS); other site
1036673002421	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1036673002422	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1036673002423	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673002424	putative active site [active]
1036673002425	heme pocket [chemical binding]; other site
1036673002426	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673002427	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673002428	metal binding site [ion binding]; metal-binding site
1036673002429	active site
1036673002430	I-site; other site
1036673002431	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673002432	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673002433	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673002434	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673002435	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673002436	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1036673002437	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673002438	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673002439	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673002440	Protein of unknown function (DUF1453); Region: DUF1453; pfam07301
1036673002441	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1036673002442	Ligand Binding Site [chemical binding]; other site
1036673002443	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1036673002444	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1036673002445	ligand binding site [chemical binding]; other site
1036673002446	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1036673002447	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673002448	Walker A/P-loop; other site
1036673002449	ATP binding site [chemical binding]; other site
1036673002450	Q-loop/lid; other site
1036673002451	ABC transporter signature motif; other site
1036673002452	Walker B; other site
1036673002453	D-loop; other site
1036673002454	H-loop/switch region; other site
1036673002455	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1036673002456	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673002457	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1036673002458	TM-ABC transporter signature motif; other site
1036673002459	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673002460	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1036673002461	TM-ABC transporter signature motif; other site
1036673002462	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1036673002463	active site
1036673002464	NTP binding site [chemical binding]; other site
1036673002465	metal binding triad [ion binding]; metal-binding site
1036673002466	antibiotic binding site [chemical binding]; other site
1036673002467	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1036673002468	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673002469	S-adenosylmethionine binding site [chemical binding]; other site
1036673002470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673002471	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673002472	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673002473	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673002474	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1036673002475	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036673002476	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673002477	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1036673002478	motif II; other site
1036673002479	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673002480	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673002481	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673002482	metal binding site [ion binding]; metal-binding site
1036673002483	active site
1036673002484	I-site; other site
1036673002485	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673002486	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1036673002487	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036673002488	Zn2+ binding site [ion binding]; other site
1036673002489	Mg2+ binding site [ion binding]; other site
1036673002490	S-layer homology domain; Region: SLH; pfam00395
1036673002491	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1036673002492	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1036673002493	active site
1036673002494	metal binding site [ion binding]; metal-binding site
1036673002495	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1036673002496	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1036673002497	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
1036673002498	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673002499	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673002500	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1036673002501	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1036673002502	putative active site [active]
1036673002503	metal binding site [ion binding]; metal-binding site
1036673002504	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
1036673002505	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1036673002506	putative trimer interface [polypeptide binding]; other site
1036673002507	putative CoA binding site [chemical binding]; other site
1036673002508	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1036673002509	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1036673002510	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1036673002511	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1036673002512	active site
1036673002513	tetramer interface; other site
1036673002514	Alginate lyase; Region: Alginate_lyase; pfam05426
1036673002515	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1036673002516	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1036673002517	putative active site [active]
1036673002518	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1036673002519	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1036673002520	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673002521	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1036673002522	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1036673002523	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1036673002524	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673002525	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
1036673002526	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1036673002527	active site
1036673002528	dimer interface [polypeptide binding]; other site
1036673002529	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1036673002530	Ligand Binding Site [chemical binding]; other site
1036673002531	Molecular Tunnel; other site
1036673002532	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
1036673002533	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101
1036673002534	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1036673002535	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1036673002536	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1036673002537	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1036673002538	Chain length determinant protein; Region: Wzz; cl15801
1036673002539	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1036673002540	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1036673002541	dimerization interface [polypeptide binding]; other site
1036673002542	active site
1036673002543	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1036673002544	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1036673002545	folate binding site [chemical binding]; other site
1036673002546	NADP+ binding site [chemical binding]; other site
1036673002547	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673002548	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673002549	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673002550	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673002551	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
1036673002552	NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195
1036673002553	NAD(P) binding site [chemical binding]; other site
1036673002554	LDH/MDH dimer interface [polypeptide binding]; other site
1036673002555	substrate binding site [chemical binding]; other site
1036673002556	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
1036673002557	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673002558	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1036673002559	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1036673002560	DXD motif; other site
1036673002561	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
1036673002562	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673002563	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673002564	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673002565	Walker A/P-loop; other site
1036673002566	ATP binding site [chemical binding]; other site
1036673002567	Q-loop/lid; other site
1036673002568	ABC transporter signature motif; other site
1036673002569	Walker B; other site
1036673002570	D-loop; other site
1036673002571	H-loop/switch region; other site
1036673002572	hypothetical protein; Provisional; Region: PRK10621
1036673002573	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1036673002574	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673002575	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1036673002576	active site
1036673002577	metal binding site [ion binding]; metal-binding site
1036673002578	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
1036673002579	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1036673002580	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
1036673002581	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1036673002582	NAD binding site [chemical binding]; other site
1036673002583	active site
1036673002584	nicotinate phosphoribosyltransferase; Region: PLN02885
1036673002585	mannosyl-3-phosphoglycerate phosphatase family; Region: HAD-SF-IIB-MPGP; TIGR01486
1036673002586	Spore germination protein; Region: Spore_permease; cl17796
1036673002587	Spore germination protein; Region: Spore_permease; cl17796
1036673002588	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673002589	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673002590	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673002591	HPP family; Region: HPP; pfam04982
1036673002592	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673002593	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673002594	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673002595	dimerization interface [polypeptide binding]; other site
1036673002596	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1036673002597	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1036673002598	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1036673002599	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1036673002600	S-formylglutathione hydrolase; Region: PLN02442
1036673002601	Predicted esterase [General function prediction only]; Region: COG0627
1036673002602	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673002603	active site
1036673002604	phosphorylation site [posttranslational modification]
1036673002605	intermolecular recognition site; other site
1036673002606	dimerization interface [polypeptide binding]; other site
1036673002607	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673002608	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673002609	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673002610	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673002611	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673002612	dimerization interface [polypeptide binding]; other site
1036673002613	Histidine kinase; Region: His_kinase; pfam06580
1036673002614	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673002615	ATP binding site [chemical binding]; other site
1036673002616	Mg2+ binding site [ion binding]; other site
1036673002617	G-X-G motif; other site
1036673002618	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673002619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673002620	dimer interface [polypeptide binding]; other site
1036673002621	conserved gate region; other site
1036673002622	ABC-ATPase subunit interface; other site
1036673002623	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673002624	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673002625	dimer interface [polypeptide binding]; other site
1036673002626	conserved gate region; other site
1036673002627	putative PBP binding loops; other site
1036673002628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673002629	ABC-ATPase subunit interface; other site
1036673002630	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673002631	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673002632	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1036673002633	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
1036673002634	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
1036673002635	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673002636	Interdomain contacts; other site
1036673002637	Cytokine receptor motif; other site
1036673002638	Chitinase [Carbohydrate transport and metabolism]; Region: ChiA; COG3325
1036673002639	The GH18 (glycosyl hydrolases, family 18) type II chitinases hydrolyze chitin, an abundant polymer of N-acetylglucosamine and have been identified in bacteria, fungi, insects, plants, viruses, and protozoan parasites. The structure of this domain is an...; Region: GH18_chitinase; cd06548
1036673002640	active site
1036673002641	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1036673002642	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1036673002643	putative trimer interface [polypeptide binding]; other site
1036673002644	putative CoA binding site [chemical binding]; other site
1036673002645	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1036673002646	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673002647	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673002648	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673002649	dimer interface [polypeptide binding]; other site
1036673002650	conserved gate region; other site
1036673002651	putative PBP binding loops; other site
1036673002652	ABC-ATPase subunit interface; other site
1036673002653	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673002654	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673002655	dimer interface [polypeptide binding]; other site
1036673002656	putative PBP binding loops; other site
1036673002657	ABC-ATPase subunit interface; other site
1036673002658	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1036673002659	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1036673002660	active site
1036673002661	ATP binding site [chemical binding]; other site
1036673002662	substrate binding site [chemical binding]; other site
1036673002663	activation loop (A-loop); other site
1036673002664	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1036673002665	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1036673002666	AAA domain; Region: AAA_31; pfam13614
1036673002667	Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis [Cell motility and secretion / Intracellular trafficking and secretion]; Region: VirB11; COG0630
1036673002668	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1036673002669	Walker A motif; other site
1036673002670	ATP binding site [chemical binding]; other site
1036673002671	Walker B motif; other site
1036673002672	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1036673002673	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1036673002674	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1036673002675	active site
1036673002676	metal-dependent hydrolase; Provisional; Region: PRK13291
1036673002677	DinB superfamily; Region: DinB_2; pfam12867
1036673002678	DinB superfamily; Region: DinB_2; pfam12867
1036673002679	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673002680	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673002681	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673002682	dimerization interface [polypeptide binding]; other site
1036673002683	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673002684	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1036673002685	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1036673002686	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1036673002687	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1036673002688	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1036673002689	GatB domain; Region: GatB_Yqey; smart00845
1036673002690	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673002691	Coenzyme A binding pocket [chemical binding]; other site
1036673002692	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1036673002693	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1036673002694	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1036673002695	MgtC family; Region: MgtC; pfam02308
1036673002696	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1036673002697	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673002698	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1036673002699	DNA binding residues [nucleotide binding]
1036673002700	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1036673002701	Uncharacterized conserved protein [Function unknown]; Region: COG3595
1036673002702	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1036673002703	ferric uptake regulator; Provisional; Region: fur; PRK09462
1036673002704	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1036673002705	metal binding site 2 [ion binding]; metal-binding site
1036673002706	putative DNA binding helix; other site
1036673002707	metal binding site 1 [ion binding]; metal-binding site
1036673002708	dimer interface [polypeptide binding]; other site
1036673002709	structural Zn2+ binding site [ion binding]; other site
1036673002710	Bacterial SH3 domain; Region: SH3_3; pfam08239
1036673002711	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1036673002712	active site
1036673002713	Protein of unknown function (DUF2614); Region: DUF2614; cl07936
1036673002714	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1036673002715	thiS-thiF/thiG interaction site; other site
1036673002716	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1036673002717	ThiS interaction site; other site
1036673002718	putative active site [active]
1036673002719	tetramer interface [polypeptide binding]; other site
1036673002720	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
1036673002721	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673002722	dimer interface [polypeptide binding]; other site
1036673002723	phosphorylation site [posttranslational modification]
1036673002724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673002725	ATP binding site [chemical binding]; other site
1036673002726	Mg2+ binding site [ion binding]; other site
1036673002727	G-X-G motif; other site
1036673002728	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1036673002729	Domain of unknown function (DUF1805); Region: DUF1805; cl01339
1036673002730	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1036673002731	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1036673002732	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1036673002733	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1036673002734	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673002735	DNA-binding site [nucleotide binding]; DNA binding site
1036673002736	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1036673002737	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1036673002738	nudix motif; other site
1036673002739	Protein of unknown function (DUF1349); Region: DUF1349; pfam07081
1036673002740	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1036673002741	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673002742	Coenzyme A binding pocket [chemical binding]; other site
1036673002743	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1036673002744	N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228
1036673002745	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1036673002746	active site
1036673002747	putative substrate binding pocket [chemical binding]; other site
1036673002748	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1036673002749	Protein of unknown function DUF58; Region: DUF58; pfam01882
1036673002750	MoxR-like ATPases [General function prediction only]; Region: COG0714
1036673002751	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673002752	Walker A motif; other site
1036673002753	ATP binding site [chemical binding]; other site
1036673002754	Walker B motif; other site
1036673002755	arginine finger; other site
1036673002756	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1036673002757	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1036673002758	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1036673002759	active site
1036673002760	Zn binding site [ion binding]; other site
1036673002761	S-layer homology domain; Region: SLH; pfam00395
1036673002762	S-layer homology domain; Region: SLH; pfam00395
1036673002763	S-layer homology domain; Region: SLH; pfam00395
1036673002764	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1036673002765	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1036673002766	Bacterial transcriptional regulator; Region: IclR; pfam01614
1036673002767	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1036673002768	classical (c) SDRs; Region: SDR_c; cd05233
1036673002769	NAD(P) binding site [chemical binding]; other site
1036673002770	active site
1036673002771	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
1036673002772	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1036673002773	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
1036673002774	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
1036673002775	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1036673002776	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673002777	NAD(P) binding site [chemical binding]; other site
1036673002778	active site
1036673002779	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1036673002780	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1036673002781	active site
1036673002782	dimer interface [polypeptide binding]; other site
1036673002783	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1036673002784	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1036673002785	active site
1036673002786	trimer interface [polypeptide binding]; other site
1036673002787	allosteric site; other site
1036673002788	active site lid [active]
1036673002789	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1036673002790	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1036673002791	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1036673002792	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1036673002793	putative active site [active]
1036673002794	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1036673002795	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
1036673002796	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
1036673002797	Domain of unknown function (DUF1802); Region: DUF1802; pfam08819
1036673002798	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1036673002799	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1036673002800	Walker A/P-loop; other site
1036673002801	ATP binding site [chemical binding]; other site
1036673002802	Q-loop/lid; other site
1036673002803	ABC transporter signature motif; other site
1036673002804	Walker B; other site
1036673002805	D-loop; other site
1036673002806	H-loop/switch region; other site
1036673002807	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1036673002808	FeS assembly protein SufD; Region: sufD; TIGR01981
1036673002809	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1036673002810	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1036673002811	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036673002812	catalytic residue [active]
1036673002813	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1036673002814	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1036673002815	trimerization site [polypeptide binding]; other site
1036673002816	active site
1036673002817	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1036673002818	FeS assembly protein SufB; Region: sufB; TIGR01980
1036673002819	BCCT family transporter; Region: BCCT; pfam02028
1036673002820	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1036673002821	Cache domain; Region: Cache_1; pfam02743
1036673002822	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673002823	dimerization interface [polypeptide binding]; other site
1036673002824	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673002825	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673002826	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673002827	dimer interface [polypeptide binding]; other site
1036673002828	putative CheW interface [polypeptide binding]; other site
1036673002829	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1036673002830	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673002831	dimerization interface [polypeptide binding]; other site
1036673002832	Cache domain; Region: Cache_1; pfam02743
1036673002833	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1036673002834	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673002835	dimerization interface [polypeptide binding]; other site
1036673002836	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673002837	dimer interface [polypeptide binding]; other site
1036673002838	putative CheW interface [polypeptide binding]; other site
1036673002839	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1036673002840	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1036673002841	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1036673002842	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
1036673002843	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1036673002844	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673002845	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673002846	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1036673002847	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673002848	active site
1036673002849	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673002850	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673002851	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1036673002852	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1036673002853	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1036673002854	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1036673002855	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1036673002856	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
1036673002857	Aspartase; Region: Aspartase; cd01357
1036673002858	active sites [active]
1036673002859	tetramer interface [polypeptide binding]; other site
1036673002860	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1036673002861	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1036673002862	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1036673002863	active site
1036673002864	homotetramer interface [polypeptide binding]; other site
1036673002865	homodimer interface [polypeptide binding]; other site
1036673002866	Bulb-type mannose-specific lectin. The domain contains a three-fold internal repeat (beta-prism architecture). The consensus sequence motif QXDXNXVXY is involved in alpha-D-mannose recognition. Lectins are carbohydrate-binding proteins which specifically...; Region: B_lectin; cd00028
1036673002867	dimerization interface [polypeptide binding]; other site
1036673002868	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673002869	MarR family; Region: MarR; pfam01047
1036673002870	active site
1036673002871	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
1036673002872	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1036673002873	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1036673002874	NAD binding site [chemical binding]; other site
1036673002875	substrate binding site [chemical binding]; other site
1036673002876	putative active site [active]
1036673002877	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1036673002878	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1036673002879	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1036673002880	hypothetical protein; Validated; Region: PRK07581
1036673002881	Homoserine acetyltransferase [Amino acid transport and metabolism]; Region: MET2; COG2021
1036673002882	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673002883	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673002884	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673002885	dimerization interface [polypeptide binding]; other site
1036673002886	hypothetical protein; Provisional; Region: PRK06184
1036673002887	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1036673002888	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1036673002889	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673002890	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673002891	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673002892	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1036673002893	conserved cys residue [active]
1036673002894	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1036673002895	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1036673002896	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673002897	putative substrate translocation pore; other site
1036673002898	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1036673002899	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1036673002900	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1036673002901	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1036673002902	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1036673002903	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1036673002904	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673002905	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673002906	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673002907	dimerization interface [polypeptide binding]; other site
1036673002908	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1036673002909	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1036673002910	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673002911	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1036673002912	NlpC/P60 family; Region: NLPC_P60; pfam00877
1036673002913	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1036673002914	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036673002915	Zn2+ binding site [ion binding]; other site
1036673002916	Mg2+ binding site [ion binding]; other site
1036673002917	thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688
1036673002918	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1036673002919	ATP binding site [chemical binding]; other site
1036673002920	substrate interface [chemical binding]; other site
1036673002921	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1036673002922	MoaE interaction surface [polypeptide binding]; other site
1036673002923	MoeB interaction surface [polypeptide binding]; other site
1036673002924	thiocarboxylated glycine; other site
1036673002925	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1036673002926	MoaE homodimer interface [polypeptide binding]; other site
1036673002927	MoaD interaction [polypeptide binding]; other site
1036673002928	active site residues [active]
1036673002929	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1036673002930	Moco binding site; other site
1036673002931	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
1036673002932	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673002933	active site
1036673002934	metal binding site [ion binding]; metal-binding site
1036673002935	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1036673002936	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
1036673002937	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673002938	FeS/SAM binding site; other site
1036673002939	YfkB-like domain; Region: YfkB; pfam08756
1036673002940	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1036673002941	Domain of unknown function DUF21; Region: DUF21; pfam01595
1036673002942	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1036673002943	Transporter associated domain; Region: CorC_HlyC; smart01091
1036673002944	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1036673002945	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1036673002946	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1036673002947	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1036673002948	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1036673002949	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1036673002950	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1036673002951	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1036673002952	NlpC/P60 family; Region: NLPC_P60; pfam00877
1036673002953	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
1036673002954	CotJB protein; Region: CotJB; pfam12652
1036673002955	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1036673002956	dinuclear metal binding motif [ion binding]; other site
1036673002957	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1036673002958	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
1036673002959	catalytic residues [active]
1036673002960	catalytic nucleophile [active]
1036673002961	Recombinase; Region: Recombinase; pfam07508
1036673002962	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
1036673002963	SEFIR domain; Region: SEFIR; pfam08357
1036673002964	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673002965	non-specific DNA binding site [nucleotide binding]; other site
1036673002966	salt bridge; other site
1036673002967	sequence-specific DNA binding site [nucleotide binding]; other site
1036673002968	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673002969	non-specific DNA binding site [nucleotide binding]; other site
1036673002970	salt bridge; other site
1036673002971	sequence-specific DNA binding site [nucleotide binding]; other site
1036673002972	Protein of unknown function (DUF2538); Region: DUF2538; pfam10804
1036673002973	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1036673002974	Preprotein translocase subunit; Region: YajC; cl00806
1036673002975	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1036673002976	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1036673002977	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1036673002978	active site
1036673002979	DNA binding site [nucleotide binding]
1036673002980	Int/Topo IB signature motif; other site
1036673002981	Phage terminase, small subunit; Region: Terminase_4; cl01525
1036673002982	Phage Terminase; Region: Terminase_1; pfam03354
1036673002983	Phage-related protein [Function unknown]; Region: COG4695
1036673002984	Phage portal protein; Region: Phage_portal; pfam04860
1036673002985	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1036673002986	Phage capsid family; Region: Phage_capsid; pfam05065
1036673002987	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
1036673002988	oligomerization interface [polypeptide binding]; other site
1036673002989	phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725
1036673002990	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
1036673002991	phage major tail protein, phi13 family; Region: maj_tail_phi13; TIGR01603
1036673002992	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1036673002993	active site
1036673002994	catalytic triad [active]
1036673002995	oxyanion hole [active]
1036673002996	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673002997	Interdomain contacts; other site
1036673002998	Cytokine receptor motif; other site
1036673002999	Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145
1036673003000	Stathmin family; Region: Stathmin; pfam00836
1036673003001	Phage-related protein [Function unknown]; Region: COG5412
1036673003002	Phage tail protein; Region: Sipho_tail; cl17486
1036673003003	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1036673003004	amidase catalytic site [active]
1036673003005	Zn binding residues [ion binding]; other site
1036673003006	substrate binding site [chemical binding]; other site
1036673003007	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1036673003008	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
1036673003009	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036673003010	MULE transposase domain; Region: MULE; pfam10551
1036673003011	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
1036673003012	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
1036673003013	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
1036673003014	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
1036673003015	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1036673003016	DNA-sulfur modification-associated; Region: DndB; pfam14072
1036673003017	DGQHR domain; Region: DGQHR; TIGR03187
1036673003018	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
1036673003019	Short C-terminal domain; Region: SHOCT; pfam09851
1036673003020	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1036673003021	dinuclear metal binding motif [ion binding]; other site
1036673003022	Protein of unknown function (DUF975); Region: DUF975; cl10504
1036673003023	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1036673003024	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673003025	motif II; other site
1036673003026	alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768
1036673003027	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1036673003028	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1036673003029	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1036673003030	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1036673003031	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1036673003032	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1036673003033	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1036673003034	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673003035	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1036673003036	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1036673003037	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673003038	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673003039	putative substrate translocation pore; other site
1036673003040	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673003041	MarR family; Region: MarR_2; pfam12802
1036673003042	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1036673003043	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1036673003044	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1036673003045	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1036673003046	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1036673003047	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1036673003048	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673003049	DNA-binding site [nucleotide binding]; DNA binding site
1036673003050	DRTGG domain; Region: DRTGG; pfam07085
1036673003051	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1036673003052	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1036673003053	active site 2 [active]
1036673003054	active site 1 [active]
1036673003055	YtpI-like protein; Region: YtpI; pfam14007
1036673003056	Sporulation protein YtrH; Region: Spore_YtrH; pfam14034
1036673003057	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
1036673003058	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
1036673003059	active site
1036673003060	PHP Thumb interface [polypeptide binding]; other site
1036673003061	metal binding site [ion binding]; metal-binding site
1036673003062	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1036673003063	generic binding surface II; other site
1036673003064	generic binding surface I; other site
1036673003065	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1036673003066	tetramer interfaces [polypeptide binding]; other site
1036673003067	binuclear metal-binding site [ion binding]; other site
1036673003068	Flavodoxin domain; Region: Flavodoxin_5; cl17428
1036673003069	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1036673003070	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
1036673003071	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1036673003072	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1036673003073	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1036673003074	pyruvate kinase; Provisional; Region: PRK06354
1036673003075	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1036673003076	domain interfaces; other site
1036673003077	active site
1036673003078	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
1036673003079	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1036673003080	active site
1036673003081	polyphosphate kinase; Provisional; Region: PRK05443
1036673003082	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
1036673003083	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
1036673003084	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
1036673003085	putative domain interface [polypeptide binding]; other site
1036673003086	putative active site [active]
1036673003087	catalytic site [active]
1036673003088	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
1036673003089	putative domain interface [polypeptide binding]; other site
1036673003090	putative active site [active]
1036673003091	catalytic site [active]
1036673003092	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
1036673003093	dimer interface [polypeptide binding]; other site
1036673003094	Citrate synthase; Region: Citrate_synt; pfam00285
1036673003095	active site
1036673003096	citrylCoA binding site [chemical binding]; other site
1036673003097	oxalacetate/citrate binding site [chemical binding]; other site
1036673003098	coenzyme A binding site [chemical binding]; other site
1036673003099	catalytic triad [active]
1036673003100	isocitrate dehydrogenase; Validated; Region: PRK06451
1036673003101	isocitrate dehydrogenase; Reviewed; Region: PRK07006
1036673003102	malate dehydrogenase; Reviewed; Region: PRK06223
1036673003103	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
1036673003104	NAD(P) binding site [chemical binding]; other site
1036673003105	dimer interface [polypeptide binding]; other site
1036673003106	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1036673003107	substrate binding site [chemical binding]; other site
1036673003108	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1036673003109	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1036673003110	nucleophilic elbow; other site
1036673003111	catalytic triad; other site
1036673003112	5'-nucleotidase; Provisional; Region: PRK03826
1036673003113	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
1036673003114	Fumarase C-terminus; Region: Fumerase_C; pfam05683
1036673003115	Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385
1036673003116	Sodium Bile acid symporter family; Region: SBF; cl17470
1036673003117	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1036673003118	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673003119	dimerization interface [polypeptide binding]; other site
1036673003120	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673003121	putative active site [active]
1036673003122	heme pocket [chemical binding]; other site
1036673003123	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673003124	dimer interface [polypeptide binding]; other site
1036673003125	phosphorylation site [posttranslational modification]
1036673003126	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673003127	ATP binding site [chemical binding]; other site
1036673003128	Mg2+ binding site [ion binding]; other site
1036673003129	G-X-G motif; other site
1036673003130	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673003131	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673003132	active site
1036673003133	phosphorylation site [posttranslational modification]
1036673003134	intermolecular recognition site; other site
1036673003135	dimerization interface [polypeptide binding]; other site
1036673003136	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673003137	DNA binding site [nucleotide binding]
1036673003138	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673003139	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673003140	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673003141	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673003142	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673003143	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673003144	CHASE3 domain; Region: CHASE3; cl05000
1036673003145	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673003146	dimerization interface [polypeptide binding]; other site
1036673003147	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673003148	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673003149	dimer interface [polypeptide binding]; other site
1036673003150	putative CheW interface [polypeptide binding]; other site
1036673003151	PBP superfamily domain; Region: PBP_like_2; cl17296
1036673003152	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1036673003153	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
1036673003154	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673003155	dimer interface [polypeptide binding]; other site
1036673003156	conserved gate region; other site
1036673003157	putative PBP binding loops; other site
1036673003158	ABC-ATPase subunit interface; other site
1036673003159	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
1036673003160	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673003161	dimer interface [polypeptide binding]; other site
1036673003162	conserved gate region; other site
1036673003163	putative PBP binding loops; other site
1036673003164	ABC-ATPase subunit interface; other site
1036673003165	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
1036673003166	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1036673003167	Walker A/P-loop; other site
1036673003168	ATP binding site [chemical binding]; other site
1036673003169	Q-loop/lid; other site
1036673003170	ABC transporter signature motif; other site
1036673003171	Walker B; other site
1036673003172	D-loop; other site
1036673003173	H-loop/switch region; other site
1036673003174	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1036673003175	PhoU domain; Region: PhoU; pfam01895
1036673003176	PhoU domain; Region: PhoU; pfam01895
1036673003177	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1036673003178	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673003179	motif II; other site
1036673003180	DNA polymerase I; Provisional; Region: PRK05755
1036673003181	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1036673003182	active site
1036673003183	metal binding site 1 [ion binding]; metal-binding site
1036673003184	putative 5' ssDNA interaction site; other site
1036673003185	metal binding site 3; metal-binding site
1036673003186	metal binding site 2 [ion binding]; metal-binding site
1036673003187	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1036673003188	putative DNA binding site [nucleotide binding]; other site
1036673003189	putative metal binding site [ion binding]; other site
1036673003190	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1036673003191	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1036673003192	active site
1036673003193	DNA binding site [nucleotide binding]
1036673003194	catalytic site [active]
1036673003195	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1036673003196	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1036673003197	DNA binding site [nucleotide binding]
1036673003198	catalytic residue [active]
1036673003199	H2TH interface [polypeptide binding]; other site
1036673003200	putative catalytic residues [active]
1036673003201	turnover-facilitating residue; other site
1036673003202	intercalation triad [nucleotide binding]; other site
1036673003203	8OG recognition residue [nucleotide binding]; other site
1036673003204	putative reading head residues; other site
1036673003205	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1036673003206	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1036673003207	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
1036673003208	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1036673003209	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1036673003210	CoA-binding site [chemical binding]; other site
1036673003211	ATP-binding [chemical binding]; other site
1036673003212	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1036673003213	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1036673003214	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1036673003215	catalytic residue [active]
1036673003216	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1036673003217	ATP cone domain; Region: ATP-cone; pfam03477
1036673003218	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
1036673003219	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1036673003220	Predicted flavoprotein [General function prediction only]; Region: COG0431
1036673003221	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1036673003222	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673003223	dimerization interface [polypeptide binding]; other site
1036673003224	putative DNA binding site [nucleotide binding]; other site
1036673003225	Winged helix-turn helix; Region: HTH_29; pfam13551
1036673003226	putative Zn2+ binding site [ion binding]; other site
1036673003227	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893
1036673003228	putative hydrophobic ligand binding site [chemical binding]; other site
1036673003229	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673003230	MarR family; Region: MarR_2; pfam12802
1036673003231	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1036673003232	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673003233	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673003234	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1036673003235	Domain of unknown function (DUF4180); Region: DUF4180; pfam13788
1036673003236	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1036673003237	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1036673003238	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
1036673003239	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673003240	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
1036673003241	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1036673003242	TPR motif; other site
1036673003243	binding surface
1036673003244	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673003245	DNA binding residues [nucleotide binding]
1036673003246	dimerization interface [polypeptide binding]; other site
1036673003247	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1036673003248	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267
1036673003249	putative NAD(P) binding site [chemical binding]; other site
1036673003250	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673003251	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673003252	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1036673003253	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673003254	Coenzyme A binding pocket [chemical binding]; other site
1036673003255	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673003256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673003257	active site
1036673003258	phosphorylation site [posttranslational modification]
1036673003259	intermolecular recognition site; other site
1036673003260	dimerization interface [polypeptide binding]; other site
1036673003261	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673003262	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673003263	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673003264	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673003265	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673003266	dimerization interface [polypeptide binding]; other site
1036673003267	Histidine kinase; Region: His_kinase; pfam06580
1036673003268	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673003269	ATP binding site [chemical binding]; other site
1036673003270	Mg2+ binding site [ion binding]; other site
1036673003271	G-X-G motif; other site
1036673003272	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673003273	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673003274	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673003275	dimer interface [polypeptide binding]; other site
1036673003276	conserved gate region; other site
1036673003277	putative PBP binding loops; other site
1036673003278	ABC-ATPase subunit interface; other site
1036673003279	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673003280	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
1036673003281	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673003282	dimer interface [polypeptide binding]; other site
1036673003283	conserved gate region; other site
1036673003284	putative PBP binding loops; other site
1036673003285	ABC-ATPase subunit interface; other site
1036673003286	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
1036673003287	Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425
1036673003288	pyruvate phosphate dikinase; Provisional; Region: PRK09279
1036673003289	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1036673003290	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1036673003291	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1036673003292	Predicted transcriptional regulators [Transcription]; Region: COG1695
1036673003293	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1036673003294	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
1036673003295	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1036673003296	active site residue [active]
1036673003297	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
1036673003298	putative homodimer interface [polypeptide binding]; other site
1036673003299	putative homotetramer interface [polypeptide binding]; other site
1036673003300	putative metal binding site [ion binding]; other site
1036673003301	putative homodimer-homodimer interface [polypeptide binding]; other site
1036673003302	putative allosteric switch controlling residues; other site
1036673003303	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1036673003304	active site residue [active]
1036673003305	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1036673003306	CPxP  motif; other site
1036673003307	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
1036673003308	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1036673003309	CPxP  motif; other site
1036673003310	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1036673003311	active site residue [active]
1036673003312	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1036673003313	active site residue [active]
1036673003314	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036673003315	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1036673003316	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673003317	Interdomain contacts; other site
1036673003318	Cytokine receptor motif; other site
1036673003319	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673003320	Interdomain contacts; other site
1036673003321	Cytokine receptor motif; other site
1036673003322	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1036673003323	dockerin binding interface; other site
1036673003324	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1036673003325	Cation efflux family; Region: Cation_efflux; pfam01545
1036673003326	Transposase domain (DUF772); Region: DUF772; pfam05598
1036673003327	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1036673003328	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1036673003329	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673003330	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1036673003331	nudix motif; other site
1036673003332	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673003333	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673003334	putative substrate translocation pore; other site
1036673003335	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1036673003336	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1036673003337	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1036673003338	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1036673003339	NAD(P) binding site [chemical binding]; other site
1036673003340	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1036673003341	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1036673003342	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673003343	Coenzyme A binding pocket [chemical binding]; other site
1036673003344	Epoxide hydrolase N terminus; Region: EHN; pfam06441
1036673003345	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1036673003346	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1036673003347	Predicted transcriptional regulator [Transcription]; Region: COG2378
1036673003348	HTH domain; Region: HTH_11; pfam08279
1036673003349	WYL domain; Region: WYL; pfam13280
1036673003350	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1036673003351	NADP binding site [chemical binding]; other site
1036673003352	short chain dehydrogenase; Provisional; Region: PRK12939
1036673003353	active site
1036673003354	substrate binding site [chemical binding]; other site
1036673003355	homodimer interface [polypeptide binding]; other site
1036673003356	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1036673003357	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_7; cd08353
1036673003358	putative dimer interface [polypeptide binding]; other site
1036673003359	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673003360	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673003361	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673003362	putative DNA binding site [nucleotide binding]; other site
1036673003363	dimerization interface [polypeptide binding]; other site
1036673003364	putative Zn2+ binding site [ion binding]; other site
1036673003365	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1036673003366	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673003367	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673003368	short chain dehydrogenase; Validated; Region: PRK08264
1036673003369	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673003370	NAD(P) binding site [chemical binding]; other site
1036673003371	active site
1036673003372	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1036673003373	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673003374	NAD(P) binding site [chemical binding]; other site
1036673003375	active site
1036673003376	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1036673003377	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1036673003378	putative NAD(P) binding site [chemical binding]; other site
1036673003379	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673003380	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673003381	putative substrate translocation pore; other site
1036673003382	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036673003383	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673003384	S-adenosylmethionine binding site [chemical binding]; other site
1036673003385	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673003386	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1036673003387	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1036673003388	Histidine kinase; Region: HisKA_3; pfam07730
1036673003389	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1036673003390	ATP binding site [chemical binding]; other site
1036673003391	Mg2+ binding site [ion binding]; other site
1036673003392	G-X-G motif; other site
1036673003393	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673003394	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673003395	active site
1036673003396	phosphorylation site [posttranslational modification]
1036673003397	intermolecular recognition site; other site
1036673003398	dimerization interface [polypeptide binding]; other site
1036673003399	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673003400	DNA binding residues [nucleotide binding]
1036673003401	dimerization interface [polypeptide binding]; other site
1036673003402	DoxX-like family; Region: DoxX_2; pfam13564
1036673003403	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673003404	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1036673003405	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673003406	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673003407	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673003408	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673003409	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673003410	Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229
1036673003411	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1036673003412	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1036673003413	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1036673003414	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1036673003415	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1036673003416	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1036673003417	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1036673003418	regulatory protein interface [polypeptide binding]; other site
1036673003419	active site
1036673003420	regulatory phosphorylation site [posttranslational modification]; other site
1036673003421	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1036673003422	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1036673003423	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1036673003424	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1036673003425	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673003426	putative substrate translocation pore; other site
1036673003427	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673003428	putative Zn2+ binding site [ion binding]; other site
1036673003429	putative DNA binding site [nucleotide binding]; other site
1036673003430	dimerization interface [polypeptide binding]; other site
1036673003431	Cache domain; Region: Cache_1; pfam02743
1036673003432	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673003433	Histidine kinase; Region: His_kinase; pfam06580
1036673003434	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673003435	ATP binding site [chemical binding]; other site
1036673003436	Mg2+ binding site [ion binding]; other site
1036673003437	G-X-G motif; other site
1036673003438	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673003439	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673003440	active site
1036673003441	phosphorylation site [posttranslational modification]
1036673003442	intermolecular recognition site; other site
1036673003443	dimerization interface [polypeptide binding]; other site
1036673003444	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673003445	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673003446	Putative catalytic NodB homology domain of uncharacterized BH1302 protein from Bacillus halodurans and its bacterial homologs; Region: CE4_BH1302_like; cd10956
1036673003447	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1036673003448	NodB motif; other site
1036673003449	putative active site [active]
1036673003450	putative catalytic site [active]
1036673003451	putative Zn binding site [ion binding]; other site
1036673003452	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673003453	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673003454	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673003455	dimer interface [polypeptide binding]; other site
1036673003456	conserved gate region; other site
1036673003457	putative PBP binding loops; other site
1036673003458	ABC-ATPase subunit interface; other site
1036673003459	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673003460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673003461	dimer interface [polypeptide binding]; other site
1036673003462	conserved gate region; other site
1036673003463	putative PBP binding loops; other site
1036673003464	ABC-ATPase subunit interface; other site
1036673003465	Protein of unknown function (DUF3500); Region: DUF3500; pfam12006
1036673003466	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
1036673003467	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1036673003468	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1036673003469	heme-binding site [chemical binding]; other site
1036673003470	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1036673003471	FAD binding pocket [chemical binding]; other site
1036673003472	FAD binding motif [chemical binding]; other site
1036673003473	phosphate binding motif [ion binding]; other site
1036673003474	beta-alpha-beta structure motif; other site
1036673003475	NAD binding pocket [chemical binding]; other site
1036673003476	Heme binding  pocket [chemical binding]; other site
1036673003477	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1036673003478	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1036673003479	ligand binding site [chemical binding]; other site
1036673003480	flexible hinge region; other site
1036673003481	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1036673003482	non-specific DNA interactions [nucleotide binding]; other site
1036673003483	DNA binding site [nucleotide binding]
1036673003484	sequence specific DNA binding site [nucleotide binding]; other site
1036673003485	putative cAMP binding site [chemical binding]; other site
1036673003486	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673003487	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673003488	Pyruvate formate lyase 1; Region: PFL1; cd01678
1036673003489	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1036673003490	coenzyme A binding site [chemical binding]; other site
1036673003491	active site
1036673003492	catalytic residues [active]
1036673003493	glycine loop; other site
1036673003494	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1036673003495	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673003496	FeS/SAM binding site; other site
1036673003497	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
1036673003498	Protein of unknown function (DUF3147); Region: DUF3147; pfam11345
1036673003499	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1036673003500	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
1036673003501	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1036673003502	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1036673003503	[4Fe-4S] binding site [ion binding]; other site
1036673003504	molybdopterin cofactor binding site; other site
1036673003505	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
1036673003506	molybdopterin cofactor binding site; other site
1036673003507	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1036673003508	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1036673003509	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1036673003510	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1036673003511	iron-sulfur cluster [ion binding]; other site
1036673003512	[2Fe-2S] cluster binding site [ion binding]; other site
1036673003513	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_1; cd08894
1036673003514	putative hydrophobic ligand binding site [chemical binding]; other site
1036673003515	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1036673003516	putative hydrophobic ligand binding site [chemical binding]; other site
1036673003517	hydroxylamine reductase; Provisional; Region: PRK12310
1036673003518	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1036673003519	ACS interaction site; other site
1036673003520	CODH interaction site; other site
1036673003521	metal cluster binding site [ion binding]; other site
1036673003522	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1036673003523	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1036673003524	ligand binding site [chemical binding]; other site
1036673003525	flexible hinge region; other site
1036673003526	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1036673003527	non-specific DNA interactions [nucleotide binding]; other site
1036673003528	DNA binding site [nucleotide binding]
1036673003529	sequence specific DNA binding site [nucleotide binding]; other site
1036673003530	putative cAMP binding site [chemical binding]; other site
1036673003531	GAF domain; Region: GAF; pfam01590
1036673003532	GAF domain; Region: GAF_2; pfam13185
1036673003533	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673003534	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673003535	active site
1036673003536	phosphorylation site [posttranslational modification]
1036673003537	intermolecular recognition site; other site
1036673003538	dimerization interface [polypeptide binding]; other site
1036673003539	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673003540	DNA binding residues [nucleotide binding]
1036673003541	dimerization interface [polypeptide binding]; other site
1036673003542	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673003543	PAS domain; Region: PAS_9; pfam13426
1036673003544	putative active site [active]
1036673003545	heme pocket [chemical binding]; other site
1036673003546	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1036673003547	Histidine kinase; Region: HisKA_3; pfam07730
1036673003548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673003549	ATP binding site [chemical binding]; other site
1036673003550	Mg2+ binding site [ion binding]; other site
1036673003551	G-X-G motif; other site
1036673003552	Hemerythrin family; Region: Hemerythrin-like; cl15774
1036673003553	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1036673003554	30S subunit binding site; other site
1036673003555	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1036673003556	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1036673003557	putative catalytic cysteine [active]
1036673003558	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1036673003559	putative active site [active]
1036673003560	metal binding site [ion binding]; metal-binding site
1036673003561	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1036673003562	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036673003563	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036673003564	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1036673003565	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1036673003566	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1036673003567	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938
1036673003568	iron-sulfur cluster [ion binding]; other site
1036673003569	[2Fe-2S] cluster binding site [ion binding]; other site
1036673003570	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1036673003571	GTP binding site; other site
1036673003572	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1036673003573	dimerization interface [polypeptide binding]; other site
1036673003574	active site
1036673003575	PAS fold; Region: PAS_4; pfam08448
1036673003576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1036673003577	putative active site [active]
1036673003578	heme pocket [chemical binding]; other site
1036673003579	PAS domain S-box; Region: sensory_box; TIGR00229
1036673003580	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673003581	putative active site [active]
1036673003582	heme pocket [chemical binding]; other site
1036673003583	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673003584	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673003585	metal binding site [ion binding]; metal-binding site
1036673003586	active site
1036673003587	I-site; other site
1036673003588	NlpC/P60 family; Region: NLPC_P60; pfam00877
1036673003589	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861
1036673003590	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1036673003591	active sites [active]
1036673003592	tetramer interface [polypeptide binding]; other site
1036673003593	urocanate hydratase; Provisional; Region: PRK05414
1036673003594	imidazolonepropionase; Validated; Region: PRK09356
1036673003595	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1036673003596	active site
1036673003597	allantoate amidohydrolase; Reviewed; Region: PRK09290
1036673003598	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1036673003599	active site
1036673003600	metal binding site [ion binding]; metal-binding site
1036673003601	dimer interface [polypeptide binding]; other site
1036673003602	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1036673003603	N-ethylammeline chlorohydrolase; Provisional; Region: PRK07228
1036673003604	active site
1036673003605	putative substrate binding pocket [chemical binding]; other site
1036673003606	Glycosyl hydrolase family 14; Region: Glyco_hydro_14; pfam01373
1036673003607	Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423
1036673003608	Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423
1036673003609	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
1036673003610	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1036673003611	active site
1036673003612	catalytic site [active]
1036673003613	Protein of unknown function (DUF1453); Region: DUF1453; cl02009
1036673003614	EamA-like transporter family; Region: EamA; pfam00892
1036673003615	Amino acid permease; Region: AA_permease_2; pfam13520
1036673003616	K+ potassium transporter; Region: K_trans; cl15781
1036673003617	Glycosyl hydrolase family 14; Region: Glyco_hydro_14; pfam01373
1036673003618	The family 20 carbohydrate-binding module (CBM20), also known as the starch-binding domain, is found in a large number of starch degrading enzymes including alpha-amylase, beta-amylase, glucoamylase, and CGTase (cyclodextrin glucanotransferase). CBM20 is...; Region: CBM20; cl15347
1036673003619	starch-binding site 2 [chemical binding]; other site
1036673003620	starch-binding site 1 [chemical binding]; other site
1036673003621	Protein of unknown function (DUF1427); Region: DUF1427; cl01771
1036673003622	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1036673003623	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
1036673003624	putative ligand binding site [chemical binding]; other site
1036673003625	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1036673003626	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1036673003627	Walker A/P-loop; other site
1036673003628	ATP binding site [chemical binding]; other site
1036673003629	Q-loop/lid; other site
1036673003630	ABC transporter signature motif; other site
1036673003631	Walker B; other site
1036673003632	D-loop; other site
1036673003633	H-loop/switch region; other site
1036673003634	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1036673003635	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673003636	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1036673003637	TM-ABC transporter signature motif; other site
1036673003638	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673003639	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1036673003640	TM-ABC transporter signature motif; other site
1036673003641	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1036673003642	nucleoside/Zn binding site; other site
1036673003643	dimer interface [polypeptide binding]; other site
1036673003644	catalytic motif [active]
1036673003645	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673003646	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673003647	dimer interface [polypeptide binding]; other site
1036673003648	putative CheW interface [polypeptide binding]; other site
1036673003649	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673003650	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673003651	DNA binding site [nucleotide binding]
1036673003652	domain linker motif; other site
1036673003653	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673003654	dimerization interface [polypeptide binding]; other site
1036673003655	ligand binding site [chemical binding]; other site
1036673003656	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1036673003657	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1036673003658	putative substrate binding site [chemical binding]; other site
1036673003659	putative ATP binding site [chemical binding]; other site
1036673003660	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1036673003661	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1036673003662	Protein involved in polysaccharide intercellular adhesin (PIA) synthesis/biofilm formation [Carbohydrate transport and metabolism]; Region: COG3936
1036673003663	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1036673003664	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1036673003665	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673003666	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673003667	active site
1036673003668	phosphorylation site [posttranslational modification]
1036673003669	intermolecular recognition site; other site
1036673003670	dimerization interface [polypeptide binding]; other site
1036673003671	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673003672	DNA binding site [nucleotide binding]
1036673003673	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673003674	dimerization interface [polypeptide binding]; other site
1036673003675	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673003676	dimer interface [polypeptide binding]; other site
1036673003677	phosphorylation site [posttranslational modification]
1036673003678	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673003679	ATP binding site [chemical binding]; other site
1036673003680	Mg2+ binding site [ion binding]; other site
1036673003681	G-X-G motif; other site
1036673003682	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1036673003683	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1036673003684	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1036673003685	S-layer homology domain; Region: SLH; pfam00395
1036673003686	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
1036673003687	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1036673003688	Carbohydrate binding domain X2; Region: CBM_X2; pfam03442
1036673003689	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673003690	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673003691	metal binding site [ion binding]; metal-binding site
1036673003692	active site
1036673003693	I-site; other site
1036673003694	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673003695	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673003696	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1036673003697	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1036673003698	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036673003699	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1036673003700	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1036673003701	putative active site [active]
1036673003702	putative metal binding site [ion binding]; other site
1036673003703	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036673003704	Domain of unknown function (DUF1200); Region: DUF1200; pfam06713
1036673003705	VanW like protein; Region: VanW; pfam04294
1036673003706	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
1036673003707	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1036673003708	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673003709	Coenzyme A binding pocket [chemical binding]; other site
1036673003710	Cache domain; Region: Cache_1; pfam02743
1036673003711	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673003712	dimerization interface [polypeptide binding]; other site
1036673003713	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673003714	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673003715	dimer interface [polypeptide binding]; other site
1036673003716	putative CheW interface [polypeptide binding]; other site
1036673003717	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1036673003718	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1036673003719	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1036673003720	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673003721	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1036673003722	Walker A/P-loop; other site
1036673003723	ATP binding site [chemical binding]; other site
1036673003724	Q-loop/lid; other site
1036673003725	ABC transporter signature motif; other site
1036673003726	Walker B; other site
1036673003727	D-loop; other site
1036673003728	H-loop/switch region; other site
1036673003729	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
1036673003730	DinB family; Region: DinB; cl17821
1036673003731	DinB superfamily; Region: DinB_2; pfam12867
1036673003732	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1036673003733	NlpC/P60 family; Region: NLPC_P60; pfam00877
1036673003734	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1036673003735	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673003736	DNA-binding site [nucleotide binding]; DNA binding site
1036673003737	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673003738	Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541
1036673003739	putative ligand binding site [chemical binding]; other site
1036673003740	putative dimerization interface [polypeptide binding]; other site
1036673003741	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
1036673003742	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398
1036673003743	intersubunit interface [polypeptide binding]; other site
1036673003744	active site
1036673003745	Zn2+ binding site [ion binding]; other site
1036673003746	ribulokinase; Provisional; Region: PRK04123
1036673003747	Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781
1036673003748	N- and C-terminal domain interface [polypeptide binding]; other site
1036673003749	active site
1036673003750	MgATP binding site [chemical binding]; other site
1036673003751	catalytic site [active]
1036673003752	metal binding site [ion binding]; metal-binding site
1036673003753	carbohydrate binding site [chemical binding]; other site
1036673003754	homodimer interface [polypeptide binding]; other site
1036673003755	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1036673003756	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036673003757	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
1036673003758	nucleotide binding site/active site [active]
1036673003759	HIT family signature motif; other site
1036673003760	catalytic residue [active]
1036673003761	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673003762	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1036673003763	FeS/SAM binding site; other site
1036673003764	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1036673003765	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673003766	MarR family; Region: MarR; pfam01047
1036673003767	Protein of unknown function (DUF2642); Region: DUF2642; pfam10842
1036673003768	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1036673003769	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1036673003770	nucleotide binding site [chemical binding]; other site
1036673003771	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1036673003772	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1036673003773	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1036673003774	binding surface
1036673003775	TPR motif; other site
1036673003776	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1036673003777	binding surface
1036673003778	TPR motif; other site
1036673003779	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1036673003780	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1036673003781	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1036673003782	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1036673003783	thiamine phosphate binding site [chemical binding]; other site
1036673003784	active site
1036673003785	pyrophosphate binding site [ion binding]; other site
1036673003786	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1036673003787	dimer interface [polypeptide binding]; other site
1036673003788	substrate binding site [chemical binding]; other site
1036673003789	ATP binding site [chemical binding]; other site
1036673003790	Uncharacterized conserved protein [Function unknown]; Region: COG2445
1036673003791	Predicted transcriptional regulator [Transcription]; Region: COG2345
1036673003792	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673003793	putative DNA binding site [nucleotide binding]; other site
1036673003794	putative Zn2+ binding site [ion binding]; other site
1036673003795	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1036673003796	active site
1036673003797	catalytic residues [active]
1036673003798	metal binding site [ion binding]; metal-binding site
1036673003799	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1036673003800	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673003801	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673003802	active site
1036673003803	phosphorylation site [posttranslational modification]
1036673003804	intermolecular recognition site; other site
1036673003805	dimerization interface [polypeptide binding]; other site
1036673003806	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673003807	DNA binding site [nucleotide binding]
1036673003808	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673003809	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673003810	dimerization interface [polypeptide binding]; other site
1036673003811	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673003812	dimer interface [polypeptide binding]; other site
1036673003813	phosphorylation site [posttranslational modification]
1036673003814	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673003815	ATP binding site [chemical binding]; other site
1036673003816	Mg2+ binding site [ion binding]; other site
1036673003817	G-X-G motif; other site
1036673003818	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1036673003819	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1036673003820	active site
1036673003821	intersubunit interface [polypeptide binding]; other site
1036673003822	catalytic residue [active]
1036673003823	Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103
1036673003824	YtxH-like protein; Region: YtxH; pfam12732
1036673003825	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1036673003826	LytTr DNA-binding domain; Region: LytTR; cl04498
1036673003827	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673003828	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673003829	metal binding site [ion binding]; metal-binding site
1036673003830	active site
1036673003831	I-site; other site
1036673003832	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673003833	Staphylococcal AgrD protein; Region: AgrD; cl05477
1036673003834	CAAX protease self-immunity; Region: Abi; pfam02517
1036673003835	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673003836	sequence-specific DNA binding site [nucleotide binding]; other site
1036673003837	salt bridge; other site
1036673003838	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
1036673003839	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
1036673003840	Glucose dehydrogenase; Region: glucose_DH; cd08230
1036673003841	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1036673003842	NADP binding site [chemical binding]; other site
1036673003843	catalytic Zn binding site [ion binding]; other site
1036673003844	structural Zn binding site [ion binding]; other site
1036673003845	dimer interface [polypeptide binding]; other site
1036673003846	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1036673003847	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1036673003848	S-layer homology domain; Region: SLH; pfam00395
1036673003849	S-layer homology domain; Region: SLH; pfam00395
1036673003850	Family description; Region: VCBS; pfam13517
1036673003851	Family description; Region: VCBS; pfam13517
1036673003852	Family description; Region: VCBS; pfam13517
1036673003853	Family description; Region: VCBS; pfam13517
1036673003854	Family description; Region: VCBS; pfam13517
1036673003855	Family description; Region: VCBS; pfam13517
1036673003856	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1036673003857	Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cd00102
1036673003858	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
1036673003859	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673003860	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673003861	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673003862	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673003863	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
1036673003864	alpha-galactosidase; Provisional; Region: PRK15076
1036673003865	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
1036673003866	NAD binding site [chemical binding]; other site
1036673003867	sugar binding site [chemical binding]; other site
1036673003868	divalent metal binding site [ion binding]; other site
1036673003869	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
1036673003870	dimer interface [polypeptide binding]; other site
1036673003871	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
1036673003872	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
1036673003873	NodB motif; other site
1036673003874	active site
1036673003875	catalytic site [active]
1036673003876	Cd binding site [ion binding]; other site
1036673003877	glutamate racemase; Provisional; Region: PRK00865
1036673003878	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673003879	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1036673003880	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673003881	Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229
1036673003882	putative active site [active]
1036673003883	Zn binding site [ion binding]; other site
1036673003884	Domain of unknown function (DUF377); Region: DUF377; pfam04041
1036673003885	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1036673003886	active site
1036673003887	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673003888	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036673003889	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673003890	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
1036673003891	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1036673003892	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673003893	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673003894	Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400
1036673003895	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
1036673003896	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673003897	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
1036673003898	SdiA-regulated; Region: SdiA-regulated; cd09971
1036673003899	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1036673003900	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1036673003901	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1036673003902	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1036673003903	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1036673003904	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1036673003905	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673003906	S-adenosylmethionine binding site [chemical binding]; other site
1036673003907	DinB superfamily; Region: DinB_2; pfam12867
1036673003908	DinB family; Region: DinB; cl17821
1036673003909	drug efflux system protein MdtG; Provisional; Region: PRK09874
1036673003910	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673003911	putative substrate translocation pore; other site
1036673003912	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
1036673003913	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673003914	active site
1036673003915	metal binding site [ion binding]; metal-binding site
1036673003916	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1036673003917	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1036673003918	putative active site [active]
1036673003919	putative metal binding site [ion binding]; other site
1036673003920	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1036673003921	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1036673003922	Integral membrane protein DUF92; Region: DUF92; pfam01940
1036673003923	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673003924	Beta propeller domain; Region: Beta_propel; pfam09826
1036673003925	Protein of unknown function (DUF1049); Region: DUF1049; cl01539
1036673003926	oligoendopeptidase F; Region: pepF; TIGR00181
1036673003927	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1036673003928	active site
1036673003929	Zn binding site [ion binding]; other site
1036673003930	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1036673003931	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1036673003932	Methyltransferase domain; Region: Methyltransf_11; pfam08241
1036673003933	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1036673003934	DNA-binding site [nucleotide binding]; DNA binding site
1036673003935	RNA-binding motif; other site
1036673003936	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
1036673003937	FMN binding site [chemical binding]; other site
1036673003938	dimer interface [polypeptide binding]; other site
1036673003939	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1036673003940	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1036673003941	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1036673003942	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1036673003943	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1036673003944	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036673003945	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1036673003946	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
1036673003947	FtsX-like permease family; Region: FtsX; pfam02687
1036673003948	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036673003949	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036673003950	Walker A/P-loop; other site
1036673003951	ATP binding site [chemical binding]; other site
1036673003952	Q-loop/lid; other site
1036673003953	ABC transporter signature motif; other site
1036673003954	Walker B; other site
1036673003955	D-loop; other site
1036673003956	H-loop/switch region; other site
1036673003957	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673003958	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673003959	putative substrate translocation pore; other site
1036673003960	Protein of unknown function (DUF2600); Region: DUF2600; pfam10776
1036673003961	6-phosphofructokinase; Provisional; Region: PRK03202
1036673003962	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1036673003963	active site
1036673003964	ADP/pyrophosphate binding site [chemical binding]; other site
1036673003965	dimerization interface [polypeptide binding]; other site
1036673003966	allosteric effector site; other site
1036673003967	fructose-1,6-bisphosphate binding site; other site
1036673003968	Protein of unknown function (DUF3906); Region: DUF3906; pfam13046
1036673003969	Predicted flavoprotein [General function prediction only]; Region: COG0431
1036673003970	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1036673003971	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1036673003972	ligand binding site [chemical binding]; other site
1036673003973	active site
1036673003974	UGI interface [polypeptide binding]; other site
1036673003975	catalytic site [active]
1036673003976	Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200
1036673003977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673003978	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673003979	putative substrate translocation pore; other site
1036673003980	twin arginine translocase protein A; Provisional; Region: tatA; PRK00575
1036673003981	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1036673003982	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1036673003983	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1036673003984	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1036673003985	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1036673003986	Domain of unknown function (DUF4247); Region: DUF4247; pfam14042
1036673003987	Domain of unknown function (DUF4178); Region: DUF4178; pfam13785
1036673003988	helicase 45; Provisional; Region: PTZ00424
1036673003989	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1036673003990	ATP binding site [chemical binding]; other site
1036673003991	Mg++ binding site [ion binding]; other site
1036673003992	motif III; other site
1036673003993	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673003994	nucleotide binding region [chemical binding]; other site
1036673003995	ATP-binding site [chemical binding]; other site
1036673003996	Protein of unknown function, DUF624; Region: DUF624; cl02369
1036673003997	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1036673003998	active site
1036673003999	intersubunit interactions; other site
1036673004000	catalytic residue [active]
1036673004001	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1036673004002	N- and C-terminal domain interface [polypeptide binding]; other site
1036673004003	D-xylulose kinase; Region: XylB; TIGR01312
1036673004004	active site
1036673004005	MgATP binding site [chemical binding]; other site
1036673004006	catalytic site [active]
1036673004007	metal binding site [ion binding]; metal-binding site
1036673004008	xylulose binding site [chemical binding]; other site
1036673004009	homodimer interface [polypeptide binding]; other site
1036673004010	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
1036673004011	non-specific DNA interactions [nucleotide binding]; other site
1036673004012	DNA binding site [nucleotide binding]
1036673004013	sequence specific DNA binding site [nucleotide binding]; other site
1036673004014	putative cAMP binding site [chemical binding]; other site
1036673004015	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1036673004016	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1036673004017	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1036673004018	Protein of unknown function (DUF1499); Region: DUF1499; cl01841
1036673004019	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1036673004020	dimer interface [polypeptide binding]; other site
1036673004021	catalytic triad [active]
1036673004022	peroxidatic and resolving cysteines [active]
1036673004023	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673004024	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673004025	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1036673004026	putative dimerization interface [polypeptide binding]; other site
1036673004027	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1036673004028	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1036673004029	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1036673004030	Predicted Zn-dependent protease [General function prediction only]; Region: COG2738
1036673004031	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1036673004032	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1036673004033	DNA binding residues [nucleotide binding]
1036673004034	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1036673004035	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1036673004036	metal binding triad; other site
1036673004037	Putative nucleotidyltransferase substrate binding domain; Region: DUF294_C; pfam10335
1036673004038	hypothetical protein; Provisional; Region: PRK07740
1036673004039	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1036673004040	active site
1036673004041	catalytic site [active]
1036673004042	substrate binding site [chemical binding]; other site
1036673004043	Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996
1036673004044	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673004045	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673004046	putative substrate translocation pore; other site
1036673004047	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1036673004048	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1036673004049	catalytic residues [active]
1036673004050	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
1036673004051	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
1036673004052	active site
1036673004053	catalytic residues [active]
1036673004054	metal binding site [ion binding]; metal-binding site
1036673004055	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1036673004056	DNA polymerase IV; Validated; Region: PRK01810
1036673004057	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1036673004058	active site
1036673004059	DNA binding site [nucleotide binding]
1036673004060	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1036673004061	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1036673004062	Walker A motif; other site
1036673004063	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
1036673004064	CHASE2 domain; Region: CHASE2; pfam05226
1036673004065	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1036673004066	cyclase homology domain; Region: CHD; cd07302
1036673004067	nucleotidyl binding site; other site
1036673004068	metal binding site [ion binding]; metal-binding site
1036673004069	dimer interface [polypeptide binding]; other site
1036673004070	FecR protein; Region: FecR; pfam04773
1036673004071	NHL repeat; Region: NHL; pfam01436
1036673004072	NHL repeat; Region: NHL; pfam01436
1036673004073	NHL repeat; Region: NHL; pfam01436
1036673004074	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673004075	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1036673004076	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1036673004077	quinone interaction residues [chemical binding]; other site
1036673004078	active site
1036673004079	catalytic residues [active]
1036673004080	FMN binding site [chemical binding]; other site
1036673004081	substrate binding site [chemical binding]; other site
1036673004082	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1036673004083	synthetase active site [active]
1036673004084	NTP binding site [chemical binding]; other site
1036673004085	metal binding site [ion binding]; metal-binding site
1036673004086	Domain of unknown function (DUF309); Region: DUF309; pfam03745
1036673004087	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1036673004088	catalytic residues [active]
1036673004089	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
1036673004090	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673004091	S-adenosylmethionine binding site [chemical binding]; other site
1036673004092	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
1036673004093	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
1036673004094	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036673004095	RNA binding surface [nucleotide binding]; other site
1036673004096	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1036673004097	active site
1036673004098	uracil binding [chemical binding]; other site
1036673004099	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1036673004100	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673004101	active site
1036673004102	motif I; other site
1036673004103	motif II; other site
1036673004104	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1036673004105	CsbD-like; Region: CsbD; cl17424
1036673004106	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
1036673004107	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673004108	S-adenosylmethionine binding site [chemical binding]; other site
1036673004109	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
1036673004110	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
1036673004111	active site
1036673004112	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, clostridial; Region: rSAM_QueE_Clost; TIGR03963
1036673004113	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673004114	FeS/SAM binding site; other site
1036673004115	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1036673004116	Ligand Binding Site [chemical binding]; other site
1036673004117	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
1036673004118	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673004119	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673004120	metal binding site [ion binding]; metal-binding site
1036673004121	active site
1036673004122	I-site; other site
1036673004123	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673004124	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1036673004125	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1036673004126	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673004127	NAD(P) binding site [chemical binding]; other site
1036673004128	active site
1036673004129	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
1036673004130	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1036673004131	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1036673004132	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036673004133	active site
1036673004134	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
1036673004135	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1036673004136	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
1036673004137	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1036673004138	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673004139	Coenzyme A binding pocket [chemical binding]; other site
1036673004140	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
1036673004141	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1036673004142	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1036673004143	active site
1036673004144	HIGH motif; other site
1036673004145	KMSK motif region; other site
1036673004146	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1036673004147	tRNA binding surface [nucleotide binding]; other site
1036673004148	anticodon binding site; other site
1036673004149	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
1036673004150	YqzE-like protein; Region: YqzE; pfam14038
1036673004151	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1036673004152	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1036673004153	transmembrane helices; other site
1036673004154	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1036673004155	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673004156	ATP binding site [chemical binding]; other site
1036673004157	putative Mg++ binding site [ion binding]; other site
1036673004158	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1036673004159	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673004160	nucleotide binding region [chemical binding]; other site
1036673004161	ATP-binding site [chemical binding]; other site
1036673004162	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1036673004163	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1036673004164	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1036673004165	homodimer interface [polypeptide binding]; other site
1036673004166	substrate-cofactor binding pocket; other site
1036673004167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673004168	catalytic residue [active]
1036673004169	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
1036673004170	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
1036673004171	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
1036673004172	active site
1036673004173	dimer interface [polypeptide binding]; other site
1036673004174	effector binding site; other site
1036673004175	TSCPD domain; Region: TSCPD; pfam12637
1036673004176	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
1036673004177	Carbohydrate Binding Module Family 6 (CBM6), Fibrobacter succinogenes S85 Xyn10D-like; appended mainly to glycoside hydrolase (GH) family 5 and GH43 domains; Region: CBM6_FsXyn10D-like; cd09838
1036673004178	putative metal binding site [ion binding]; other site
1036673004179	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673004180	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673004181	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673004182	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004183	dimer interface [polypeptide binding]; other site
1036673004184	conserved gate region; other site
1036673004185	putative PBP binding loops; other site
1036673004186	ABC-ATPase subunit interface; other site
1036673004187	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673004188	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004189	dimer interface [polypeptide binding]; other site
1036673004190	conserved gate region; other site
1036673004191	putative PBP binding loops; other site
1036673004192	ABC-ATPase subunit interface; other site
1036673004193	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1036673004194	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1036673004195	inhibitor binding site; inhibition site
1036673004196	active site
1036673004197	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
1036673004198	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1036673004199	The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402
1036673004200	catalytic site [active]
1036673004201	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1036673004202	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673004203	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673004204	dimerization interface [polypeptide binding]; other site
1036673004205	Histidine kinase; Region: His_kinase; pfam06580
1036673004206	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673004207	ATP binding site [chemical binding]; other site
1036673004208	Mg2+ binding site [ion binding]; other site
1036673004209	G-X-G motif; other site
1036673004210	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673004211	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673004212	active site
1036673004213	phosphorylation site [posttranslational modification]
1036673004214	intermolecular recognition site; other site
1036673004215	dimerization interface [polypeptide binding]; other site
1036673004216	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004217	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673004218	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004219	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673004220	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673004221	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004222	dimer interface [polypeptide binding]; other site
1036673004223	conserved gate region; other site
1036673004224	putative PBP binding loops; other site
1036673004225	ABC-ATPase subunit interface; other site
1036673004226	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673004227	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004228	dimer interface [polypeptide binding]; other site
1036673004229	conserved gate region; other site
1036673004230	putative PBP binding loops; other site
1036673004231	ABC-ATPase subunit interface; other site
1036673004232	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673004233	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1036673004234	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
1036673004235	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673004236	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673004237	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004238	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
1036673004239	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
1036673004240	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1036673004241	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
1036673004242	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673004243	dimerization interface [polypeptide binding]; other site
1036673004244	Histidine kinase; Region: His_kinase; pfam06580
1036673004245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673004246	ATP binding site [chemical binding]; other site
1036673004247	Mg2+ binding site [ion binding]; other site
1036673004248	G-X-G motif; other site
1036673004249	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1036673004250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673004251	active site
1036673004252	phosphorylation site [posttranslational modification]
1036673004253	intermolecular recognition site; other site
1036673004254	dimerization interface [polypeptide binding]; other site
1036673004255	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004256	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004257	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673004258	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673004259	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1036673004260	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1036673004261	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673004262	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1036673004263	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673004264	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004265	dimer interface [polypeptide binding]; other site
1036673004266	conserved gate region; other site
1036673004267	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673004268	ABC-ATPase subunit interface; other site
1036673004269	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673004270	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004271	ABC-ATPase subunit interface; other site
1036673004272	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1036673004273	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1036673004274	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1036673004275	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004276	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673004277	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004278	Cupin domain; Region: Cupin_2; cl17218
1036673004279	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004280	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673004281	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004282	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1036673004283	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673004284	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673004285	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004286	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673004287	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673004288	active site
1036673004289	catalytic tetrad [active]
1036673004290	Creatinine amidohydrolase; Region: Creatininase; pfam02633
1036673004291	beta-D-glucuronidase; Provisional; Region: PRK10150
1036673004292	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1036673004293	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673004294	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1036673004295	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1036673004296	classical (c) SDRs; Region: SDR_c; cd05233
1036673004297	NAD(P) binding site [chemical binding]; other site
1036673004298	active site
1036673004299	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1036673004300	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673004301	NAD(P) binding site [chemical binding]; other site
1036673004302	active site
1036673004303	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673004304	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673004305	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004306	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004307	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1036673004308	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
1036673004309	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673004310	Interdomain contacts; other site
1036673004311	Cytokine receptor motif; other site
1036673004312	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673004313	Interdomain contacts; other site
1036673004314	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673004315	Interdomain contacts; other site
1036673004316	Cytokine receptor motif; other site
1036673004317	Melibiase; Region: Melibiase; pfam02065
1036673004318	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1036673004319	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673004320	active site
1036673004321	phosphorylation site [posttranslational modification]
1036673004322	intermolecular recognition site; other site
1036673004323	dimerization interface [polypeptide binding]; other site
1036673004324	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004325	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004326	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673004327	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673004328	dimerization interface [polypeptide binding]; other site
1036673004329	Histidine kinase; Region: His_kinase; pfam06580
1036673004330	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673004331	ATP binding site [chemical binding]; other site
1036673004332	Mg2+ binding site [ion binding]; other site
1036673004333	G-X-G motif; other site
1036673004334	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673004335	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004336	dimer interface [polypeptide binding]; other site
1036673004337	conserved gate region; other site
1036673004338	ABC-ATPase subunit interface; other site
1036673004339	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673004340	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004341	ABC-ATPase subunit interface; other site
1036673004342	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673004343	Right handed beta helix region; Region: Beta_helix; pfam13229
1036673004344	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1036673004345	metal binding site [ion binding]; metal-binding site
1036673004346	Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082
1036673004347	Ca binding site [ion binding]; other site
1036673004348	Ca binding site (active) [ion binding]; other site
1036673004349	ligand binding site [chemical binding]; other site
1036673004350	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
1036673004351	putative ligand binding site [chemical binding]; other site
1036673004352	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1036673004353	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1036673004354	Right handed beta helix region; Region: Beta_helix; pfam13229
1036673004355	Spore germination protein; Region: Spore_permease; cl17796
1036673004356	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673004357	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673004358	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673004359	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
1036673004360	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1036673004361	Cupin domain; Region: Cupin_2; pfam07883
1036673004362	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673004363	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004364	FAD binding domain; Region: FAD_binding_1; pfam00667
1036673004365	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1036673004366	FAD binding pocket [chemical binding]; other site
1036673004367	FAD binding motif [chemical binding]; other site
1036673004368	catalytic residues [active]
1036673004369	NAD binding pocket [chemical binding]; other site
1036673004370	phosphate binding motif [ion binding]; other site
1036673004371	beta-alpha-beta structure motif; other site
1036673004372	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673004373	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673004374	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004375	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673004376	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673004377	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1036673004378	dimer interface [polypeptide binding]; other site
1036673004379	active site
1036673004380	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1036673004381	dimer interface [polypeptide binding]; other site
1036673004382	active site
1036673004383	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1036673004384	Ribokinase-like subgroup A.  Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942
1036673004385	substrate binding site [chemical binding]; other site
1036673004386	ATP binding site [chemical binding]; other site
1036673004387	Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191
1036673004388	alpha-mannosidase; Provisional; Region: PRK09819
1036673004389	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
1036673004390	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1036673004391	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673004392	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673004393	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004394	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1036673004395	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1036673004396	substrate binding site [chemical binding]; other site
1036673004397	dimer interface [polypeptide binding]; other site
1036673004398	ATP binding site [chemical binding]; other site
1036673004399	PAS fold; Region: PAS_4; pfam08448
1036673004400	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673004401	putative active site [active]
1036673004402	heme pocket [chemical binding]; other site
1036673004403	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673004404	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673004405	metal binding site [ion binding]; metal-binding site
1036673004406	active site
1036673004407	I-site; other site
1036673004408	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1036673004409	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673004410	I-site; other site
1036673004411	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1036673004412	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673004413	non-specific DNA binding site [nucleotide binding]; other site
1036673004414	salt bridge; other site
1036673004415	sequence-specific DNA binding site [nucleotide binding]; other site
1036673004416	Cupin domain; Region: Cupin_2; pfam07883
1036673004417	Cupin domain; Region: Cupin_2; pfam07883
1036673004418	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1036673004419	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673004420	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673004421	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1036673004422	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1036673004423	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
1036673004424	active site
1036673004425	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1036673004426	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1036673004427	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673004428	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673004429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004430	dimer interface [polypeptide binding]; other site
1036673004431	conserved gate region; other site
1036673004432	putative PBP binding loops; other site
1036673004433	ABC-ATPase subunit interface; other site
1036673004434	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673004435	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004436	dimer interface [polypeptide binding]; other site
1036673004437	conserved gate region; other site
1036673004438	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673004439	ABC-ATPase subunit interface; other site
1036673004440	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673004441	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004442	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673004443	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673004444	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004445	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004446	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG2159
1036673004447	Ferredoxin subunits of nitrite reductase and ring-hydroxylating dioxygenases [Inorganic ion transport and metabolism / General function prediction only]; Region: {NirD}; COG2146
1036673004448	iron-sulfur cluster [ion binding]; other site
1036673004449	[2Fe-2S] cluster binding site [ion binding]; other site
1036673004450	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1036673004451	Endo-beta-mannanase [Carbohydrate transport and metabolism]; Region: COG3934
1036673004452	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673004453	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673004454	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004455	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673004456	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004457	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673004458	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004459	dimer interface [polypeptide binding]; other site
1036673004460	conserved gate region; other site
1036673004461	ABC-ATPase subunit interface; other site
1036673004462	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673004463	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004464	dimer interface [polypeptide binding]; other site
1036673004465	conserved gate region; other site
1036673004466	ABC-ATPase subunit interface; other site
1036673004467	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673004468	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673004469	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
1036673004470	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673004471	Spore germination protein; Region: Spore_permease; cl17796
1036673004472	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673004473	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673004474	Predicted transcriptional regulators [Transcription]; Region: COG1695
1036673004475	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1036673004476	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
1036673004477	Protein of unknown function (DUF1048); Region: DUF1048; pfam06304
1036673004478	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
1036673004479	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673004480	Walker A/P-loop; other site
1036673004481	ATP binding site [chemical binding]; other site
1036673004482	Q-loop/lid; other site
1036673004483	ABC transporter signature motif; other site
1036673004484	Walker B; other site
1036673004485	D-loop; other site
1036673004486	H-loop/switch region; other site
1036673004487	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1036673004488	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1036673004489	HAMP domain; Region: HAMP; pfam00672
1036673004490	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673004491	dimer interface [polypeptide binding]; other site
1036673004492	phosphorylation site [posttranslational modification]
1036673004493	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673004494	ATP binding site [chemical binding]; other site
1036673004495	Mg2+ binding site [ion binding]; other site
1036673004496	G-X-G motif; other site
1036673004497	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673004498	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673004499	active site
1036673004500	phosphorylation site [posttranslational modification]
1036673004501	intermolecular recognition site; other site
1036673004502	dimerization interface [polypeptide binding]; other site
1036673004503	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673004504	DNA binding site [nucleotide binding]
1036673004505	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1036673004506	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1036673004507	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1036673004508	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1036673004509	HEAT repeats; Region: HEAT_2; pfam13646
1036673004510	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673004511	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673004512	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004513	2-hydroxyacid dehydrogenase; Provisional; Region: PRK08410
1036673004514	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
1036673004515	putative ligand binding site [chemical binding]; other site
1036673004516	putative NAD binding site [chemical binding]; other site
1036673004517	catalytic site [active]
1036673004518	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1036673004519	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
1036673004520	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1036673004521	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1036673004522	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
1036673004523	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
1036673004524	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004525	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036673004526	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
1036673004527	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673004528	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004529	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673004530	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004531	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673004532	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673004533	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673004534	dimerization interface [polypeptide binding]; other site
1036673004535	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673004536	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673004537	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673004538	dimerization interface [polypeptide binding]; other site
1036673004539	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1036673004540	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673004541	dimerization interface [polypeptide binding]; other site
1036673004542	Histidine kinase; Region: His_kinase; pfam06580
1036673004543	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673004544	ATP binding site [chemical binding]; other site
1036673004545	Mg2+ binding site [ion binding]; other site
1036673004546	G-X-G motif; other site
1036673004547	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673004548	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673004549	active site
1036673004550	phosphorylation site [posttranslational modification]
1036673004551	intermolecular recognition site; other site
1036673004552	dimerization interface [polypeptide binding]; other site
1036673004553	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673004554	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004555	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673004556	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673004557	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673004558	dimerization interface [polypeptide binding]; other site
1036673004559	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1036673004560	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036673004561	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1036673004562	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673004563	active site
1036673004564	metal binding site [ion binding]; metal-binding site
1036673004565	Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089
1036673004566	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673004567	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673004568	dimerization interface [polypeptide binding]; other site
1036673004569	Histidine kinase; Region: His_kinase; pfam06580
1036673004570	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1036673004571	Mg2+ binding site [ion binding]; other site
1036673004572	G-X-G motif; other site
1036673004573	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673004574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673004575	active site
1036673004576	phosphorylation site [posttranslational modification]
1036673004577	intermolecular recognition site; other site
1036673004578	dimerization interface [polypeptide binding]; other site
1036673004579	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673004580	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004581	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673004582	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673004583	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673004584	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673004585	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004586	dimer interface [polypeptide binding]; other site
1036673004587	ABC-ATPase subunit interface; other site
1036673004588	putative PBP binding loops; other site
1036673004589	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673004590	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004591	dimer interface [polypeptide binding]; other site
1036673004592	conserved gate region; other site
1036673004593	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673004594	ABC-ATPase subunit interface; other site
1036673004595	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
1036673004596	active site
1036673004597	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1036673004598	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1036673004599	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1036673004600	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1036673004601	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
1036673004602	active site
1036673004603	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1036673004604	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1036673004605	Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156
1036673004606	active site
1036673004607	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673004608	Interdomain contacts; other site
1036673004609	Cytokine receptor motif; other site
1036673004610	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1036673004611	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1036673004612	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673004613	Interdomain contacts; other site
1036673004614	Cytokine receptor motif; other site
1036673004615	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1036673004616	dockerin binding interface; other site
1036673004617	Helix-Turn-Helix DNA binding domain of the transcription regulators NolA and AlbR; Region: HTH_NolA-AlbR; cd04788
1036673004618	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1036673004619	DNA binding residues [nucleotide binding]
1036673004620	putative dimer interface [polypeptide binding]; other site
1036673004621	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1036673004622	hydrophobic ligand binding site; other site
1036673004623	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1036673004624	classical (c) SDRs; Region: SDR_c; cd05233
1036673004625	NAD(P) binding site [chemical binding]; other site
1036673004626	active site
1036673004627	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1036673004628	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004629	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036673004630	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
1036673004631	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
1036673004632	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673004633	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1036673004634	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673004635	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673004636	LytTr DNA-binding domain; Region: LytTR; smart00850
1036673004637	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1036673004638	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1036673004639	Transcription antiterminator [Transcription]; Region: NusG; COG0250
1036673004640	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000
1036673004641	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500
1036673004642	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1036673004643	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1036673004644	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
1036673004645	FMN binding site [chemical binding]; other site
1036673004646	substrate binding site [chemical binding]; other site
1036673004647	putative catalytic residue [active]
1036673004648	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1036673004649	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1036673004650	active site
1036673004651	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1036673004652	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1036673004653	putative NADP binding site [chemical binding]; other site
1036673004654	KR domain; Region: KR; pfam08659
1036673004655	active site
1036673004656	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673004657	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1036673004658	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1036673004659	active site
1036673004660	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1036673004661	putative NADP binding site [chemical binding]; other site
1036673004662	active site
1036673004663	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673004664	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1036673004665	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1036673004666	active site
1036673004667	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1036673004668	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1036673004669	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1036673004670	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1036673004671	active site
1036673004672	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1036673004673	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1036673004674	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1036673004675	putative NADP binding site [chemical binding]; other site
1036673004676	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1036673004677	active site
1036673004678	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673004679	S-adenosylmethionine binding site [chemical binding]; other site
1036673004680	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1036673004681	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1036673004682	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1036673004683	active site
1036673004684	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1036673004685	KR domain; Region: KR; pfam08659
1036673004686	putative NADP binding site [chemical binding]; other site
1036673004687	active site
1036673004688	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673004689	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1036673004690	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1036673004691	active site
1036673004692	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673004693	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1036673004694	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1036673004695	active site
1036673004696	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1036673004697	putative NADP binding site [chemical binding]; other site
1036673004698	KR domain; Region: KR; pfam08659
1036673004699	active site
1036673004700	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673004701	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1036673004702	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1036673004703	active site
1036673004704	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673004705	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1036673004706	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1036673004707	active site
1036673004708	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1036673004709	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1036673004710	putative NADP binding site [chemical binding]; other site
1036673004711	KR domain; Region: KR; pfam08659
1036673004712	active site
1036673004713	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1036673004714	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1036673004715	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1036673004716	active site
1036673004717	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673004718	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1036673004719	Acyl transferase domain; Region: Acyl_transf_1; cl08282
1036673004720	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1036673004721	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
1036673004722	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
1036673004723	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1036673004724	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1036673004725	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673004726	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673004727	DNA binding site [nucleotide binding]
1036673004728	domain linker motif; other site
1036673004729	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
1036673004730	dimerization interface [polypeptide binding]; other site
1036673004731	ligand binding site [chemical binding]; other site
1036673004732	sodium binding site [ion binding]; other site
1036673004733	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673004734	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004735	dimer interface [polypeptide binding]; other site
1036673004736	conserved gate region; other site
1036673004737	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673004738	ABC-ATPase subunit interface; other site
1036673004739	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673004740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004741	dimer interface [polypeptide binding]; other site
1036673004742	conserved gate region; other site
1036673004743	putative PBP binding loops; other site
1036673004744	ABC-ATPase subunit interface; other site
1036673004745	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673004746	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1036673004747	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1036673004748	substrate binding [chemical binding]; other site
1036673004749	active site
1036673004750	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1036673004751	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1036673004752	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
1036673004753	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1036673004754	substrate binding [chemical binding]; other site
1036673004755	active site
1036673004756	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1036673004757	S-layer homology domain; Region: SLH; pfam00395
1036673004758	S-layer homology domain; Region: SLH; pfam00395
1036673004759	Phosphotransferase enzyme family; Region: APH; pfam01636
1036673004760	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1036673004761	active site
1036673004762	ATP binding site [chemical binding]; other site
1036673004763	substrate binding site [chemical binding]; other site
1036673004764	Sporulation inhibitor A; Region: Sda; pfam08970
1036673004765	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1036673004766	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
1036673004767	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1036673004768	substrate binding [chemical binding]; other site
1036673004769	active site
1036673004770	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1036673004771	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1036673004772	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1036673004773	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673004774	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
1036673004775	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
1036673004776	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036673004777	inhibitor-cofactor binding pocket; inhibition site
1036673004778	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673004779	catalytic residue [active]
1036673004780	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1036673004781	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1036673004782	NAD(P) binding site [chemical binding]; other site
1036673004783	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1036673004784	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673004785	motif II; other site
1036673004786	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1036673004787	active site
1036673004788	Diaminopimelate epimerase [Amino acid transport and metabolism]; Region: DapF; COG0253
1036673004789	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1036673004790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4408
1036673004791	Uncharacterized protein conserved in bacteria (DUF2338); Region: DUF2338; pfam10100
1036673004792	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1036673004793	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
1036673004794	substrate binding site [chemical binding]; other site
1036673004795	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1036673004796	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004797	dimer interface [polypeptide binding]; other site
1036673004798	conserved gate region; other site
1036673004799	putative PBP binding loops; other site
1036673004800	ABC-ATPase subunit interface; other site
1036673004801	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1036673004802	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1036673004803	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004804	dimer interface [polypeptide binding]; other site
1036673004805	conserved gate region; other site
1036673004806	putative PBP binding loops; other site
1036673004807	ABC-ATPase subunit interface; other site
1036673004808	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1036673004809	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673004810	Walker A/P-loop; other site
1036673004811	ATP binding site [chemical binding]; other site
1036673004812	Q-loop/lid; other site
1036673004813	ABC transporter signature motif; other site
1036673004814	Walker B; other site
1036673004815	D-loop; other site
1036673004816	H-loop/switch region; other site
1036673004817	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1036673004818	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673004819	Walker A/P-loop; other site
1036673004820	ATP binding site [chemical binding]; other site
1036673004821	Q-loop/lid; other site
1036673004822	ABC transporter signature motif; other site
1036673004823	Walker B; other site
1036673004824	D-loop; other site
1036673004825	H-loop/switch region; other site
1036673004826	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673004827	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673004828	putative substrate translocation pore; other site
1036673004829	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673004830	dimerization interface [polypeptide binding]; other site
1036673004831	putative DNA binding site [nucleotide binding]; other site
1036673004832	putative Zn2+ binding site [ion binding]; other site
1036673004833	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1036673004834	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1036673004835	metal-binding site [ion binding]
1036673004836	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1036673004837	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1036673004838	DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906
1036673004839	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673004840	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
1036673004841	dimerization interface [polypeptide binding]; other site
1036673004842	substrate binding pocket [chemical binding]; other site
1036673004843	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022
1036673004844	putative deacylase active site [active]
1036673004845	EamA-like transporter family; Region: EamA; cl17759
1036673004846	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1036673004847	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
1036673004848	Pectate lyase; Region: Pec_lyase_C; cl01593
1036673004849	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1036673004850	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673004851	Interdomain contacts; other site
1036673004852	Cytokine receptor motif; other site
1036673004853	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673004854	Interdomain contacts; other site
1036673004855	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673004856	Interdomain contacts; other site
1036673004857	Cytokine receptor motif; other site
1036673004858	putative pectinesterase; Region: PLN02432; cl01911
1036673004859	Pectinesterase; Region: Pectinesterase; pfam01095
1036673004860	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673004861	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004862	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673004863	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004864	dimer interface [polypeptide binding]; other site
1036673004865	conserved gate region; other site
1036673004866	ABC-ATPase subunit interface; other site
1036673004867	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673004868	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673004869	dimer interface [polypeptide binding]; other site
1036673004870	conserved gate region; other site
1036673004871	putative PBP binding loops; other site
1036673004872	ABC-ATPase subunit interface; other site
1036673004873	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673004874	Predicted transcriptional regulators [Transcription]; Region: COG1378
1036673004875	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
1036673004876	Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124
1036673004877	C-terminal domain interface [polypeptide binding]; other site
1036673004878	sugar binding site [chemical binding]; other site
1036673004879	AzlC protein; Region: AzlC; cl00570
1036673004880	YxiJ-like protein; Region: YxiJ; pfam14176
1036673004881	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673004882	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673004883	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1036673004884	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1036673004885	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
1036673004886	NADP binding site [chemical binding]; other site
1036673004887	substrate binding site [chemical binding]; other site
1036673004888	active site
1036673004889	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036673004890	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1036673004891	FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666
1036673004892	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036673004893	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1036673004894	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036673004895	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004896	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1036673004897	classical (c) SDRs; Region: SDR_c; cd05233
1036673004898	NAD(P) binding site [chemical binding]; other site
1036673004899	active site
1036673004900	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673004901	Walker A/P-loop; other site
1036673004902	ATP binding site [chemical binding]; other site
1036673004903	Q-loop/lid; other site
1036673004904	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1036673004905	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1036673004906	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1036673004907	DinB family; Region: DinB; cl17821
1036673004908	DinB superfamily; Region: DinB_2; pfam12867
1036673004909	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1036673004910	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1036673004911	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1036673004912	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1036673004913	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
1036673004914	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1036673004915	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1036673004916	substrate binding site [chemical binding]; other site
1036673004917	ATP binding site [chemical binding]; other site
1036673004918	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1036673004919	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1036673004920	intersubunit interface [polypeptide binding]; other site
1036673004921	active site
1036673004922	zinc binding site [ion binding]; other site
1036673004923	Na+ binding site [ion binding]; other site
1036673004924	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1036673004925	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1036673004926	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1036673004927	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1036673004928	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1036673004929	active site
1036673004930	dimerization interface [polypeptide binding]; other site
1036673004931	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
1036673004932	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1036673004933	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1036673004934	putative NAD(P) binding site [chemical binding]; other site
1036673004935	catalytic Zn binding site [ion binding]; other site
1036673004936	structural Zn binding site [ion binding]; other site
1036673004937	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673004938	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673004939	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673004940	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673004941	dimerization interface [polypeptide binding]; other site
1036673004942	Histidine kinase; Region: His_kinase; pfam06580
1036673004943	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673004944	ATP binding site [chemical binding]; other site
1036673004945	Mg2+ binding site [ion binding]; other site
1036673004946	G-X-G motif; other site
1036673004947	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673004948	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673004949	active site
1036673004950	phosphorylation site [posttranslational modification]
1036673004951	intermolecular recognition site; other site
1036673004952	dimerization interface [polypeptide binding]; other site
1036673004953	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673004954	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673004955	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
1036673004956	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
1036673004957	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
1036673004958	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
1036673004959	S-layer homology domain; Region: SLH; pfam00395
1036673004960	S-layer homology domain; Region: SLH; pfam00395
1036673004961	S-layer homology domain; Region: SLH; pfam00395
1036673004962	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1036673004963	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1036673004964	Walker A/P-loop; other site
1036673004965	ATP binding site [chemical binding]; other site
1036673004966	Q-loop/lid; other site
1036673004967	ABC transporter signature motif; other site
1036673004968	Walker B; other site
1036673004969	D-loop; other site
1036673004970	H-loop/switch region; other site
1036673004971	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1036673004972	Walker A/P-loop; other site
1036673004973	ATP binding site [chemical binding]; other site
1036673004974	Q-loop/lid; other site
1036673004975	ABC transporter signature motif; other site
1036673004976	Walker B; other site
1036673004977	D-loop; other site
1036673004978	H-loop/switch region; other site
1036673004979	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1036673004980	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
1036673004981	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673004982	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673004983	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673004984	dimerization interface [polypeptide binding]; other site
1036673004985	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1036673004986	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1036673004987	Protein of unknown function (DUF1572); Region: DUF1572; pfam07609
1036673004988	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1036673004989	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673004990	Coenzyme A binding pocket [chemical binding]; other site
1036673004991	Predicted transcriptional regulators [Transcription]; Region: COG1695
1036673004992	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1036673004993	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1036673004994	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1036673004995	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1036673004996	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1036673004997	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673004998	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673004999	hypothetical protein; Validated; Region: PRK06186
1036673005000	conserved cys residue [active]
1036673005001	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036673005002	MULE transposase domain; Region: MULE; pfam10551
1036673005003	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005004	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005005	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1036673005006	Histidine kinase; Region: His_kinase; pfam06580
1036673005007	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673005008	ATP binding site [chemical binding]; other site
1036673005009	Mg2+ binding site [ion binding]; other site
1036673005010	G-X-G motif; other site
1036673005011	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673005012	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673005013	active site
1036673005014	phosphorylation site [posttranslational modification]
1036673005015	intermolecular recognition site; other site
1036673005016	dimerization interface [polypeptide binding]; other site
1036673005017	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673005018	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005019	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005020	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1036673005021	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1036673005022	substrate binding [chemical binding]; other site
1036673005023	active site
1036673005024	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1036673005025	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673005026	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005027	putative PBP binding loops; other site
1036673005028	ABC-ATPase subunit interface; other site
1036673005029	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005030	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005031	dimer interface [polypeptide binding]; other site
1036673005032	conserved gate region; other site
1036673005033	putative PBP binding loops; other site
1036673005034	ABC-ATPase subunit interface; other site
1036673005035	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1036673005036	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1036673005037	substrate binding [chemical binding]; other site
1036673005038	active site
1036673005039	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1036673005040	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
1036673005041	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1036673005042	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1036673005043	substrate binding [chemical binding]; other site
1036673005044	active site
1036673005045	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1036673005046	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673005047	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673005048	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1036673005049	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1036673005050	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673005051	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673005052	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
1036673005053	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673005054	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673005055	putative substrate translocation pore; other site
1036673005056	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1036673005057	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673005058	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005059	dimer interface [polypeptide binding]; other site
1036673005060	conserved gate region; other site
1036673005061	ABC-ATPase subunit interface; other site
1036673005062	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005064	dimer interface [polypeptide binding]; other site
1036673005065	conserved gate region; other site
1036673005066	putative PBP binding loops; other site
1036673005067	ABC-ATPase subunit interface; other site
1036673005068	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005069	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005070	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673005071	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005072	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673005073	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673005074	Predicted membrane protein [Function unknown]; Region: COG4270
1036673005075	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1036673005076	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1036673005077	putative NAD(P) binding site [chemical binding]; other site
1036673005078	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1036673005079	active site
1036673005080	catalytic triad [active]
1036673005081	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1036673005082	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673005083	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005084	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673005085	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005086	dimer interface [polypeptide binding]; other site
1036673005087	conserved gate region; other site
1036673005088	ABC-ATPase subunit interface; other site
1036673005089	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005090	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005091	dimer interface [polypeptide binding]; other site
1036673005092	conserved gate region; other site
1036673005093	putative PBP binding loops; other site
1036673005094	ABC-ATPase subunit interface; other site
1036673005095	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005096	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1036673005097	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673005098	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673005099	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005100	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1036673005101	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1036673005102	metal binding site [ion binding]; metal-binding site
1036673005103	active site
1036673005104	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1036673005105	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
1036673005106	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
1036673005107	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1036673005108	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_11; cd06321
1036673005109	putative ligand binding site [chemical binding]; other site
1036673005110	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1036673005111	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1036673005112	Walker A/P-loop; other site
1036673005113	ATP binding site [chemical binding]; other site
1036673005114	Q-loop/lid; other site
1036673005115	ABC transporter signature motif; other site
1036673005116	Walker B; other site
1036673005117	D-loop; other site
1036673005118	H-loop/switch region; other site
1036673005119	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1036673005120	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673005121	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1036673005122	TM-ABC transporter signature motif; other site
1036673005123	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673005124	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673005125	DNA binding site [nucleotide binding]
1036673005126	domain linker motif; other site
1036673005127	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673005128	dimerization interface [polypeptide binding]; other site
1036673005129	ligand binding site [chemical binding]; other site
1036673005130	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673005131	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673005132	DNA binding site [nucleotide binding]
1036673005133	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1036673005134	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673005135	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005136	ABC-ATPase subunit interface; other site
1036673005137	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005138	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005139	dimer interface [polypeptide binding]; other site
1036673005140	conserved gate region; other site
1036673005141	putative PBP binding loops; other site
1036673005142	ABC-ATPase subunit interface; other site
1036673005143	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005144	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005145	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1036673005146	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1036673005147	substrate binding [chemical binding]; other site
1036673005148	active site
1036673005149	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1036673005150	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
1036673005151	Isochorismatase family; Region: Isochorismatase; pfam00857
1036673005152	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
1036673005153	catalytic triad [active]
1036673005154	dimer interface [polypeptide binding]; other site
1036673005155	conserved cis-peptide bond; other site
1036673005156	Protein of unknown function (DUF1427); Region: DUF1427; pfam07235
1036673005157	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1036673005158	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1036673005159	active site
1036673005160	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
1036673005161	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673005162	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1036673005163	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673005164	putative substrate translocation pore; other site
1036673005165	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1036673005166	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1036673005167	dimerization interface [polypeptide binding]; other site
1036673005168	DPS ferroxidase diiron center [ion binding]; other site
1036673005169	ion pore; other site
1036673005170	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1036673005171	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1036673005172	substrate binding pocket [chemical binding]; other site
1036673005173	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1036673005174	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1036673005175	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673005176	Zn binding site [ion binding]; other site
1036673005177	C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347
1036673005178	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673005179	Zn binding site [ion binding]; other site
1036673005180	Predicted esterase [General function prediction only]; Region: COG0400
1036673005181	putative hydrolase; Provisional; Region: PRK11460
1036673005182	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1036673005183	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1036673005184	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1036673005185	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
1036673005186	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673005187	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673005188	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005189	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005190	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
1036673005191	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
1036673005192	Protein of unknown function (DUF3024); Region: DUF3024; pfam11225
1036673005193	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1036673005194	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1036673005195	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1036673005196	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1036673005197	putative DNA binding site [nucleotide binding]; other site
1036673005198	putative Zn2+ binding site [ion binding]; other site
1036673005199	AsnC family; Region: AsnC_trans_reg; pfam01037
1036673005200	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673005201	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673005202	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673005203	dimerization interface [polypeptide binding]; other site
1036673005204	putative DNA binding site [nucleotide binding]; other site
1036673005205	putative Zn2+ binding site [ion binding]; other site
1036673005206	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673005207	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1036673005208	putative substrate translocation pore; other site
1036673005209	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673005210	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005211	dimer interface [polypeptide binding]; other site
1036673005212	conserved gate region; other site
1036673005213	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673005214	ABC-ATPase subunit interface; other site
1036673005215	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005217	dimer interface [polypeptide binding]; other site
1036673005218	conserved gate region; other site
1036673005219	putative PBP binding loops; other site
1036673005220	ABC-ATPase subunit interface; other site
1036673005221	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005222	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005223	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673005224	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005225	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1036673005226	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673005227	ABC-ATPase subunit  interface; other site
1036673005228	dimer interface [polypeptide binding]; other site
1036673005229	putative PBP binding regions; other site
1036673005230	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1036673005231	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673005232	ABC-ATPase subunit  interface; other site
1036673005233	dimer interface [polypeptide binding]; other site
1036673005234	putative PBP binding regions; other site
1036673005235	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1036673005236	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1036673005237	intersubunit interface [polypeptide binding]; other site
1036673005238	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1036673005239	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1036673005240	Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733
1036673005241	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1036673005242	metal binding site [ion binding]; metal-binding site
1036673005243	active site
1036673005244	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673005245	Interdomain contacts; other site
1036673005246	Cytokine receptor motif; other site
1036673005247	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673005248	Interdomain contacts; other site
1036673005249	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1036673005250	dockerin binding interface; other site
1036673005251	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1036673005252	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
1036673005253	inhibitor binding site; inhibition site
1036673005254	catalytic Zn binding site [ion binding]; other site
1036673005255	structural Zn binding site [ion binding]; other site
1036673005256	NADP binding site [chemical binding]; other site
1036673005257	tetramer interface [polypeptide binding]; other site
1036673005258	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1036673005259	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1036673005260	AAA ATPase domain; Region: AAA_16; pfam13191
1036673005261	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1036673005262	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1036673005263	TPR motif; other site
1036673005264	binding surface
1036673005265	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1036673005266	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673005267	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673005268	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673005269	Spore germination protein; Region: Spore_permease; cl17796
1036673005270	Spore germination protein; Region: Spore_permease; cl17796
1036673005271	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1036673005272	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673005273	non-specific DNA binding site [nucleotide binding]; other site
1036673005274	salt bridge; other site
1036673005275	sequence-specific DNA binding site [nucleotide binding]; other site
1036673005276	SET domain; Region: SET; pfam00856
1036673005277	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897
1036673005278	putative hydrophobic ligand binding site [chemical binding]; other site
1036673005279	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673005280	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005281	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005282	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005283	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673005284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005285	dimer interface [polypeptide binding]; other site
1036673005286	conserved gate region; other site
1036673005287	putative PBP binding loops; other site
1036673005288	ABC-ATPase subunit interface; other site
1036673005289	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005290	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005291	dimer interface [polypeptide binding]; other site
1036673005292	conserved gate region; other site
1036673005293	ABC-ATPase subunit interface; other site
1036673005294	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1036673005295	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673005296	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1036673005297	Bacterial Ig-like domain (group 1); Region: Big_1; cl17740
1036673005298	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1036673005299	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673005300	DNA-binding site [nucleotide binding]; DNA binding site
1036673005301	FCD domain; Region: FCD; pfam07729
1036673005302	mannonate dehydratase; Provisional; Region: PRK03906
1036673005303	mannonate dehydratase; Region: uxuA; TIGR00695
1036673005304	D-mannonate oxidoreductase; Provisional; Region: PRK08277
1036673005305	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
1036673005306	putative NAD(P) binding site [chemical binding]; other site
1036673005307	active site
1036673005308	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1036673005309	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1036673005310	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673005311	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005312	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036673005313	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005314	Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512
1036673005315	Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661
1036673005316	Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648
1036673005317	Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477
1036673005318	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1036673005319	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1036673005320	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1036673005321	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673005322	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005323	dimer interface [polypeptide binding]; other site
1036673005324	putative PBP binding loops; other site
1036673005325	ABC-ATPase subunit interface; other site
1036673005326	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005328	dimer interface [polypeptide binding]; other site
1036673005329	conserved gate region; other site
1036673005330	putative PBP binding loops; other site
1036673005331	ABC-ATPase subunit interface; other site
1036673005332	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673005333	Histidine kinase; Region: His_kinase; pfam06580
1036673005334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673005335	ATP binding site [chemical binding]; other site
1036673005336	Mg2+ binding site [ion binding]; other site
1036673005337	G-X-G motif; other site
1036673005338	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005339	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005340	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673005341	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673005342	active site
1036673005343	phosphorylation site [posttranslational modification]
1036673005344	intermolecular recognition site; other site
1036673005345	dimerization interface [polypeptide binding]; other site
1036673005346	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005347	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673005348	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005349	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1036673005350	Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285
1036673005351	inhibitor binding site; inhibition site
1036673005352	catalytic Zn binding site [ion binding]; other site
1036673005353	structural Zn binding site [ion binding]; other site
1036673005354	NADP binding site [chemical binding]; other site
1036673005355	tetramer interface [polypeptide binding]; other site
1036673005356	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
1036673005357	ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636
1036673005358	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1036673005359	active site
1036673005360	DNA binding site [nucleotide binding]
1036673005361	The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424
1036673005362	Benzoate membrane transport protein; Region: BenE; pfam03594
1036673005363	benzoate transporter; Region: benE; TIGR00843
1036673005364	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
1036673005365	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1036673005366	NAD binding site [chemical binding]; other site
1036673005367	substrate binding site [chemical binding]; other site
1036673005368	putative active site [active]
1036673005369	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1036673005370	UbiA prenyltransferase family; Region: UbiA; pfam01040
1036673005371	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673005372	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036673005373	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005374	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1036673005375	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1036673005376	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
1036673005377	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1036673005378	NAD(P) binding site [chemical binding]; other site
1036673005379	catalytic residues [active]
1036673005380	putative dehydratase; Provisional; Region: PRK08211
1036673005381	Dehydratase family; Region: ILVD_EDD; cl00340
1036673005382	malate:quinone oxidoreductase; Validated; Region: PRK05257
1036673005383	malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320
1036673005384	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673005385	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673005386	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673005387	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005388	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1036673005389	2-keto-3-deoxygluconate permease; Region: KdgT; cl14653
1036673005390	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1036673005391	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1036673005392	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1036673005393	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673005394	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005395	Cupin domain; Region: Cupin_2; pfam07883
1036673005396	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673005397	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005398	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1036673005399	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1036673005400	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
1036673005401	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
1036673005402	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1036673005403	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673005404	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1036673005405	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1036673005406	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1036673005407	dimerization domain swap beta strand [polypeptide binding]; other site
1036673005408	regulatory protein interface [polypeptide binding]; other site
1036673005409	active site
1036673005410	regulatory phosphorylation site [posttranslational modification]; other site
1036673005411	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1036673005412	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1036673005413	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
1036673005414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005415	dimer interface [polypeptide binding]; other site
1036673005416	conserved gate region; other site
1036673005417	ABC-ATPase subunit interface; other site
1036673005418	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005419	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005420	dimer interface [polypeptide binding]; other site
1036673005421	conserved gate region; other site
1036673005422	ABC-ATPase subunit interface; other site
1036673005423	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1036673005424	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1036673005425	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005426	S-layer homology domain; Region: SLH; pfam00395
1036673005427	S-layer homology domain; Region: SLH; pfam00395
1036673005428	S-layer homology domain; Region: SLH; pfam00395
1036673005429	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
1036673005430	Carbohydrate binding module 27; Region: CBM27; pfam09212
1036673005431	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673005432	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673005433	dimerization interface [polypeptide binding]; other site
1036673005434	Histidine kinase; Region: His_kinase; pfam06580
1036673005435	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673005436	ATP binding site [chemical binding]; other site
1036673005437	Mg2+ binding site [ion binding]; other site
1036673005438	G-X-G motif; other site
1036673005439	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1036673005440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673005441	active site
1036673005442	phosphorylation site [posttranslational modification]
1036673005443	intermolecular recognition site; other site
1036673005444	dimerization interface [polypeptide binding]; other site
1036673005445	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005446	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005447	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005448	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1036673005449	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1036673005450	active site
1036673005451	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
1036673005452	dimerization interface [polypeptide binding]; other site
1036673005453	putative active cleft [active]
1036673005454	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
1036673005455	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
1036673005456	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1036673005457	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1036673005458	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673005459	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673005460	active site
1036673005461	phosphorylation site [posttranslational modification]
1036673005462	intermolecular recognition site; other site
1036673005463	dimerization interface [polypeptide binding]; other site
1036673005464	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673005465	DNA binding site [nucleotide binding]
1036673005466	Carbohydrate binding domain (family 25); Region: CBM_25; cl04060
1036673005467	Carbohydrate binding domain; Region: CBM_25; smart01066
1036673005468	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673005469	Interdomain contacts; other site
1036673005470	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
1036673005471	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1036673005472	Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339
1036673005473	active site
1036673005474	catalytic site [active]
1036673005475	CHASE3 domain; Region: CHASE3; cl05000
1036673005476	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673005477	dimerization interface [polypeptide binding]; other site
1036673005478	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673005479	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673005480	metal binding site [ion binding]; metal-binding site
1036673005481	active site
1036673005482	I-site; other site
1036673005483	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005484	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005485	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1036673005486	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673005487	active site
1036673005488	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005489	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005490	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673005491	dimerization interface [polypeptide binding]; other site
1036673005492	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673005493	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673005494	dimer interface [polypeptide binding]; other site
1036673005495	putative CheW interface [polypeptide binding]; other site
1036673005496	Histidine kinase; Region: His_kinase; pfam06580
1036673005497	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673005498	ATP binding site [chemical binding]; other site
1036673005499	Mg2+ binding site [ion binding]; other site
1036673005500	G-X-G motif; other site
1036673005501	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673005502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673005503	active site
1036673005504	phosphorylation site [posttranslational modification]
1036673005505	intermolecular recognition site; other site
1036673005506	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673005507	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005508	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005509	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1036673005510	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1036673005511	Ca binding site [ion binding]; other site
1036673005512	active site
1036673005513	catalytic site [active]
1036673005514	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1036673005515	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005516	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1036673005517	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1036673005518	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005519	dimer interface [polypeptide binding]; other site
1036673005520	conserved gate region; other site
1036673005521	putative PBP binding loops; other site
1036673005522	ABC-ATPase subunit interface; other site
1036673005523	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005524	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005525	dimer interface [polypeptide binding]; other site
1036673005526	conserved gate region; other site
1036673005527	putative PBP binding loops; other site
1036673005528	ABC-ATPase subunit interface; other site
1036673005529	Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199
1036673005530	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1036673005531	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1036673005532	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
1036673005533	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1036673005534	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
1036673005535	Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083
1036673005536	putative metal binding site [ion binding]; other site
1036673005537	Arrestin (or S-antigen), C-terminal domain; Region: Arrestin_C; pfam02752
1036673005538	Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199
1036673005539	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1036673005540	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673005541	Interdomain contacts; other site
1036673005542	Cytokine receptor motif; other site
1036673005543	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1036673005544	dockerin binding interface; other site
1036673005545	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673005546	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673005547	dimerization interface [polypeptide binding]; other site
1036673005548	Histidine kinase; Region: His_kinase; pfam06580
1036673005549	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673005550	ATP binding site [chemical binding]; other site
1036673005551	Mg2+ binding site [ion binding]; other site
1036673005552	G-X-G motif; other site
1036673005553	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673005554	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673005555	active site
1036673005556	phosphorylation site [posttranslational modification]
1036673005557	intermolecular recognition site; other site
1036673005558	dimerization interface [polypeptide binding]; other site
1036673005559	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005560	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673005561	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005562	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1036673005563	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005564	dimer interface [polypeptide binding]; other site
1036673005565	conserved gate region; other site
1036673005566	putative PBP binding loops; other site
1036673005567	ABC-ATPase subunit interface; other site
1036673005568	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005569	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005570	dimer interface [polypeptide binding]; other site
1036673005571	conserved gate region; other site
1036673005572	putative PBP binding loops; other site
1036673005573	ABC-ATPase subunit interface; other site
1036673005574	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005575	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005576	Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626
1036673005577	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1036673005578	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1036673005579	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673005580	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673005581	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673005582	Spore germination protein; Region: Spore_permease; cl17796
1036673005583	DinB family; Region: DinB; cl17821
1036673005584	DinB superfamily; Region: DinB_2; pfam12867
1036673005585	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673005586	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673005587	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673005588	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1036673005589	metal binding site [ion binding]; metal-binding site
1036673005590	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; pfam10022
1036673005591	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673005592	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673005593	dimerization interface [polypeptide binding]; other site
1036673005594	Histidine kinase; Region: His_kinase; pfam06580
1036673005595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673005596	ATP binding site [chemical binding]; other site
1036673005597	Mg2+ binding site [ion binding]; other site
1036673005598	G-X-G motif; other site
1036673005599	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673005600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673005601	active site
1036673005602	phosphorylation site [posttranslational modification]
1036673005603	intermolecular recognition site; other site
1036673005604	dimerization interface [polypeptide binding]; other site
1036673005605	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005606	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673005607	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005608	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005609	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005610	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1036673005611	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673005612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673005613	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673005614	dimerization interface [polypeptide binding]; other site
1036673005615	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1036673005616	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1036673005617	hinge; other site
1036673005618	active site
1036673005619	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1036673005620	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1036673005621	Tetramer interface [polypeptide binding]; other site
1036673005622	active site
1036673005623	FMN-binding site [chemical binding]; other site
1036673005624	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673005625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005626	dimer interface [polypeptide binding]; other site
1036673005627	conserved gate region; other site
1036673005628	putative PBP binding loops; other site
1036673005629	ABC-ATPase subunit interface; other site
1036673005630	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005631	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005632	dimer interface [polypeptide binding]; other site
1036673005633	conserved gate region; other site
1036673005634	putative PBP binding loops; other site
1036673005635	ABC-ATPase subunit interface; other site
1036673005636	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005637	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005638	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1036673005639	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1036673005640	catalytic residues [active]
1036673005641	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1036673005642	metal-binding site [ion binding]
1036673005643	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1036673005644	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673005645	putative substrate translocation pore; other site
1036673005646	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673005647	MarR family; Region: MarR_2; pfam12802
1036673005648	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673005649	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
1036673005650	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1036673005651	The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112
1036673005652	P-loop, Walker A motif; other site
1036673005653	Base recognition motif; other site
1036673005654	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1036673005655	S-layer homology domain; Region: SLH; pfam00395
1036673005656	amidase; Provisional; Region: PRK06828
1036673005657	Amidase; Region: Amidase; pfam01425
1036673005658	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673005659	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673005660	metal binding site [ion binding]; metal-binding site
1036673005661	active site
1036673005662	I-site; other site
1036673005663	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
1036673005664	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1036673005665	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1036673005666	dockerin binding interface; other site
1036673005667	S-layer homology domain; Region: SLH; pfam00395
1036673005668	S-layer homology domain; Region: SLH; pfam00395
1036673005669	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673005670	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005671	dimer interface [polypeptide binding]; other site
1036673005672	conserved gate region; other site
1036673005673	ABC-ATPase subunit interface; other site
1036673005674	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005675	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005676	dimer interface [polypeptide binding]; other site
1036673005677	ABC-ATPase subunit interface; other site
1036673005678	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005679	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1036673005680	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1036673005681	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1036673005682	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1036673005683	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1036673005684	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673005685	MarR family; Region: MarR; pfam01047
1036673005686	MarR family; Region: MarR_2; cl17246
1036673005687	Pirin; Region: Pirin; pfam02678
1036673005688	Pirin-related protein [General function prediction only]; Region: COG1741
1036673005689	Predicted membrane protein [Function unknown]; Region: COG2259
1036673005690	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1036673005691	dimerization interface [polypeptide binding]; other site
1036673005692	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673005693	Histidine kinase; Region: His_kinase; pfam06580
1036673005694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673005695	ATP binding site [chemical binding]; other site
1036673005696	Mg2+ binding site [ion binding]; other site
1036673005697	G-X-G motif; other site
1036673005698	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673005699	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673005700	active site
1036673005701	phosphorylation site [posttranslational modification]
1036673005702	intermolecular recognition site; other site
1036673005703	dimerization interface [polypeptide binding]; other site
1036673005704	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673005705	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005706	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
1036673005707	SnoaL-like domain; Region: SnoaL_3; pfam13474
1036673005708	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1036673005709	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673005710	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005711	dimer interface [polypeptide binding]; other site
1036673005712	conserved gate region; other site
1036673005713	ABC-ATPase subunit interface; other site
1036673005714	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005715	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005716	dimer interface [polypeptide binding]; other site
1036673005717	conserved gate region; other site
1036673005718	putative PBP binding loops; other site
1036673005719	ABC-ATPase subunit interface; other site
1036673005720	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005721	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005722	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673005723	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673005724	dimerization interface [polypeptide binding]; other site
1036673005725	Histidine kinase; Region: His_kinase; pfam06580
1036673005726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673005727	ATP binding site [chemical binding]; other site
1036673005728	Mg2+ binding site [ion binding]; other site
1036673005729	G-X-G motif; other site
1036673005730	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1036673005731	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673005732	active site
1036673005733	phosphorylation site [posttranslational modification]
1036673005734	intermolecular recognition site; other site
1036673005735	dimerization interface [polypeptide binding]; other site
1036673005736	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005737	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005738	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1036673005739	catalytic core [active]
1036673005740	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
1036673005741	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1036673005742	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673005743	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1036673005744	catalytic site [active]
1036673005745	Predicted transcriptional regulator [Transcription]; Region: COG2378
1036673005746	HTH domain; Region: HTH_11; pfam08279
1036673005747	WYL domain; Region: WYL; pfam13280
1036673005748	Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041
1036673005749	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3813
1036673005750	Protein of unknown function (DUF1272); Region: DUF1272; pfam06906
1036673005751	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1036673005752	active site
1036673005753	putative catalytic site [active]
1036673005754	DNA binding site [nucleotide binding]
1036673005755	putative phosphate binding site [ion binding]; other site
1036673005756	metal binding site A [ion binding]; metal-binding site
1036673005757	AP binding site [nucleotide binding]; other site
1036673005758	metal binding site B [ion binding]; metal-binding site
1036673005759	PilZ domain; Region: PilZ; pfam07238
1036673005760	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673005761	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005762	dimer interface [polypeptide binding]; other site
1036673005763	conserved gate region; other site
1036673005764	ABC-ATPase subunit interface; other site
1036673005765	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005766	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005767	dimer interface [polypeptide binding]; other site
1036673005768	conserved gate region; other site
1036673005769	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673005770	ABC-ATPase subunit interface; other site
1036673005771	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673005772	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673005773	dimerization interface [polypeptide binding]; other site
1036673005774	Histidine kinase; Region: His_kinase; pfam06580
1036673005775	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673005776	ATP binding site [chemical binding]; other site
1036673005777	Mg2+ binding site [ion binding]; other site
1036673005778	G-X-G motif; other site
1036673005779	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673005780	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673005781	active site
1036673005782	phosphorylation site [posttranslational modification]
1036673005783	intermolecular recognition site; other site
1036673005784	dimerization interface [polypeptide binding]; other site
1036673005785	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005786	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673005787	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005788	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005789	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005790	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673005791	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1036673005792	NAD(P) binding site [chemical binding]; other site
1036673005793	active site
1036673005794	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
1036673005795	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
1036673005796	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673005797	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673005798	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005799	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005800	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673005801	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673005802	dimer interface [polypeptide binding]; other site
1036673005803	phosphorylation site [posttranslational modification]
1036673005804	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673005805	ATP binding site [chemical binding]; other site
1036673005806	Mg2+ binding site [ion binding]; other site
1036673005807	G-X-G motif; other site
1036673005808	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673005809	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673005810	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673005811	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673005812	putative substrate translocation pore; other site
1036673005813	Predicted transcriptional regulators [Transcription]; Region: COG1510
1036673005814	MarR family; Region: MarR_2; cl17246
1036673005815	BCCT family transporter; Region: BCCT; pfam02028
1036673005816	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1036673005817	Predicted transcriptional regulator [Transcription]; Region: COG4189
1036673005818	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673005819	dimerization interface [polypeptide binding]; other site
1036673005820	putative DNA binding site [nucleotide binding]; other site
1036673005821	putative Zn2+ binding site [ion binding]; other site
1036673005822	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1036673005823	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673005824	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1036673005825	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005826	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005827	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673005828	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673005829	dimerization interface [polypeptide binding]; other site
1036673005830	Histidine kinase; Region: His_kinase; pfam06580
1036673005831	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673005832	ATP binding site [chemical binding]; other site
1036673005833	Mg2+ binding site [ion binding]; other site
1036673005834	G-X-G motif; other site
1036673005835	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673005836	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673005837	active site
1036673005838	phosphorylation site [posttranslational modification]
1036673005839	intermolecular recognition site; other site
1036673005840	dimerization interface [polypeptide binding]; other site
1036673005841	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1036673005842	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673005843	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005844	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005845	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005846	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673005847	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005848	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673005849	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005850	dimer interface [polypeptide binding]; other site
1036673005851	conserved gate region; other site
1036673005852	ABC-ATPase subunit interface; other site
1036673005853	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673005854	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005855	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005856	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005857	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1036673005858	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1036673005859	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1036673005860	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1036673005861	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673005862	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673005863	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005864	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005865	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005866	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005867	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673005868	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005869	putative PBP binding loops; other site
1036673005870	ABC-ATPase subunit interface; other site
1036673005871	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005872	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005873	dimer interface [polypeptide binding]; other site
1036673005874	conserved gate region; other site
1036673005875	putative PBP binding loops; other site
1036673005876	ABC-ATPase subunit interface; other site
1036673005877	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1036673005878	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488
1036673005879	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673005880	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673005881	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1036673005882	active site
1036673005883	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1036673005884	Phosphotransferase enzyme family; Region: APH; pfam01636
1036673005885	active site
1036673005886	substrate binding site [chemical binding]; other site
1036673005887	ATP binding site [chemical binding]; other site
1036673005888	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1036673005889	substrate binding site [chemical binding]; other site
1036673005890	catalytic residues [active]
1036673005891	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
1036673005892	putative hydrophobic ligand binding site [chemical binding]; other site
1036673005893	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673005894	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673005895	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005896	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005897	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005899	dimer interface [polypeptide binding]; other site
1036673005900	conserved gate region; other site
1036673005901	putative PBP binding loops; other site
1036673005902	ABC-ATPase subunit interface; other site
1036673005903	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005905	dimer interface [polypeptide binding]; other site
1036673005906	conserved gate region; other site
1036673005907	putative PBP binding loops; other site
1036673005908	ABC-ATPase subunit interface; other site
1036673005909	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
1036673005910	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1036673005911	Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599
1036673005912	putative active site [active]
1036673005913	putative catalytic site [active]
1036673005914	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673005915	HAMP domain; Region: HAMP; pfam00672
1036673005916	Histidine kinase; Region: His_kinase; pfam06580
1036673005917	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673005918	ATP binding site [chemical binding]; other site
1036673005919	Mg2+ binding site [ion binding]; other site
1036673005920	G-X-G motif; other site
1036673005921	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1036673005922	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673005923	active site
1036673005924	phosphorylation site [posttranslational modification]
1036673005925	intermolecular recognition site; other site
1036673005926	dimerization interface [polypeptide binding]; other site
1036673005927	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005928	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005929	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005930	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005931	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005932	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005933	putative PBP binding loops; other site
1036673005934	dimer interface [polypeptide binding]; other site
1036673005935	ABC-ATPase subunit interface; other site
1036673005936	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005937	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005938	dimer interface [polypeptide binding]; other site
1036673005939	conserved gate region; other site
1036673005940	putative PBP binding loops; other site
1036673005941	ABC-ATPase subunit interface; other site
1036673005942	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1036673005943	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1036673005944	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673005945	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673005946	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1036673005947	Histidine kinase; Region: HisKA_3; pfam07730
1036673005948	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673005949	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673005950	active site
1036673005951	phosphorylation site [posttranslational modification]
1036673005952	intermolecular recognition site; other site
1036673005953	dimerization interface [polypeptide binding]; other site
1036673005954	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673005955	DNA binding residues [nucleotide binding]
1036673005956	dimerization interface [polypeptide binding]; other site
1036673005957	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673005958	putative substrate translocation pore; other site
1036673005959	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673005960	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673005961	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673005962	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673005963	dimerization interface [polypeptide binding]; other site
1036673005964	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673005965	Coenzyme A binding pocket [chemical binding]; other site
1036673005966	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673005967	S-adenosylmethionine binding site [chemical binding]; other site
1036673005968	Protein of unknown function (DUF3895); Region: DUF3895; pfam13034
1036673005969	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1036673005970	DNA-binding site [nucleotide binding]; DNA binding site
1036673005971	RNA-binding motif; other site
1036673005972	Cold-inducible protein YdjO; Region: YdjO; pfam14169
1036673005973	GRAS family transcription factor; Region: GRAS; pfam03514
1036673005974	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673005975	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673005976	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005977	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673005978	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673005979	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673005980	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005981	dimer interface [polypeptide binding]; other site
1036673005982	conserved gate region; other site
1036673005983	putative PBP binding loops; other site
1036673005984	ABC-ATPase subunit interface; other site
1036673005985	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673005986	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673005987	dimer interface [polypeptide binding]; other site
1036673005988	conserved gate region; other site
1036673005989	putative PBP binding loops; other site
1036673005990	ABC-ATPase subunit interface; other site
1036673005991	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
1036673005992	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
1036673005993	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
1036673005994	Predicted transcriptional regulator [Transcription]; Region: COG2378
1036673005995	HTH domain; Region: HTH_11; pfam08279
1036673005996	WYL domain; Region: WYL; pfam13280
1036673005997	TfoX C-terminal domain; Region: TfoX_C; pfam04994
1036673005998	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673005999	microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential  for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th,  Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212
1036673006000	active site
1036673006001	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673006002	S-adenosylmethionine binding site [chemical binding]; other site
1036673006003	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673006004	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
1036673006005	dimer interface [polypeptide binding]; other site
1036673006006	putative metal binding site [ion binding]; other site
1036673006007	LysE type translocator; Region: LysE; pfam01810
1036673006008	Phosphotransferase enzyme family; Region: APH; pfam01636
1036673006009	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1036673006010	substrate binding site [chemical binding]; other site
1036673006011	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673006012	Coenzyme A binding pocket [chemical binding]; other site
1036673006013	AAA domain; Region: AAA_18; pfam13238
1036673006014	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1036673006015	active site
1036673006016	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1036673006017	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1036673006018	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673006019	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673006020	ABC transporter; Region: ABC_tran_2; pfam12848
1036673006021	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673006022	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1036673006023	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1036673006024	EamA-like transporter family; Region: EamA; pfam00892
1036673006025	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1036673006026	EamA-like transporter family; Region: EamA; pfam00892
1036673006027	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1036673006028	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1036673006029	DNA binding residues [nucleotide binding]
1036673006030	putative dimer interface [polypeptide binding]; other site
1036673006031	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
1036673006032	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1036673006033	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1036673006034	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1036673006035	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673006036	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673006037	active site
1036673006038	catalytic tetrad [active]
1036673006039	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1036673006040	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1036673006041	active site
1036673006042	catalytic triad [active]
1036673006043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673006044	Walker A motif; other site
1036673006045	ATP binding site [chemical binding]; other site
1036673006046	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673006047	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673006048	DNA binding residues [nucleotide binding]
1036673006049	dimerization interface [polypeptide binding]; other site
1036673006050	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1036673006051	Cytochrome P450; Region: p450; pfam00067
1036673006052	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
1036673006053	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673006054	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673006055	active site
1036673006056	phosphorylation site [posttranslational modification]
1036673006057	intermolecular recognition site; other site
1036673006058	dimerization interface [polypeptide binding]; other site
1036673006059	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673006060	DNA binding site [nucleotide binding]
1036673006061	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673006062	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673006063	dimer interface [polypeptide binding]; other site
1036673006064	phosphorylation site [posttranslational modification]
1036673006065	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673006066	ATP binding site [chemical binding]; other site
1036673006067	Mg2+ binding site [ion binding]; other site
1036673006068	G-X-G motif; other site
1036673006069	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1036673006070	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1036673006071	Walker A/P-loop; other site
1036673006072	ATP binding site [chemical binding]; other site
1036673006073	Q-loop/lid; other site
1036673006074	ABC transporter signature motif; other site
1036673006075	Walker B; other site
1036673006076	D-loop; other site
1036673006077	H-loop/switch region; other site
1036673006078	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1036673006079	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1036673006080	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1036673006081	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1036673006082	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
1036673006083	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1036673006084	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673006085	dimerization interface [polypeptide binding]; other site
1036673006086	putative DNA binding site [nucleotide binding]; other site
1036673006087	putative Zn2+ binding site [ion binding]; other site
1036673006088	EamA-like transporter family; Region: EamA; pfam00892
1036673006089	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1036673006090	EamA-like transporter family; Region: EamA; pfam00892
1036673006091	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673006092	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673006093	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673006094	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673006095	putative substrate translocation pore; other site
1036673006096	Predicted transcriptional regulators [Transcription]; Region: COG1695
1036673006097	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1036673006098	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
1036673006099	substrate binding site [chemical binding]; other site
1036673006100	active site
1036673006101	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
1036673006102	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1036673006103	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DinB; COG2318
1036673006104	DinB superfamily; Region: DinB_2; pfam12867
1036673006105	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1036673006106	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673006107	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
1036673006108	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1036673006109	classical (c) SDRs; Region: SDR_c; cd05233
1036673006110	NAD(P) binding site [chemical binding]; other site
1036673006111	active site
1036673006112	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673006113	Predicted transcriptional regulators [Transcription]; Region: COG1695
1036673006114	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673006115	salt bridge; other site
1036673006116	non-specific DNA binding site [nucleotide binding]; other site
1036673006117	sequence-specific DNA binding site [nucleotide binding]; other site
1036673006118	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1036673006119	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1036673006120	NAD(P) binding site [chemical binding]; other site
1036673006121	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192
1036673006122	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1036673006123	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1036673006124	homodimer interface [polypeptide binding]; other site
1036673006125	NADP binding site [chemical binding]; other site
1036673006126	substrate binding site [chemical binding]; other site
1036673006127	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1036673006128	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673006129	Coenzyme A binding pocket [chemical binding]; other site
1036673006130	oligoendopeptidase F; Region: pepF; TIGR00181
1036673006131	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1036673006132	active site
1036673006133	Zn binding site [ion binding]; other site
1036673006134	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673006135	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673006136	Trans-2-enoyl-CoA reductase (TER) and 2,4-dienoyl-CoA reductase (DECR), atypical (a) SDR; Region: TER_DECR_SDR_a; cd05369
1036673006137	NAD(P) binding site [chemical binding]; other site
1036673006138	short chain dehydrogenase; Provisional; Region: PRK07677
1036673006139	substrate binding site [chemical binding]; other site
1036673006140	homotetramer interface [polypeptide binding]; other site
1036673006141	active site
1036673006142	homodimer interface [polypeptide binding]; other site
1036673006143	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1036673006144	active site
1036673006145	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673006146	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673006147	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673006148	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673006149	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673006150	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673006151	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673006152	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673006153	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673006154	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673006155	Interdomain contacts; other site
1036673006156	Cytokine receptor motif; other site
1036673006157	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1036673006158	dockerin binding interface; other site
1036673006159	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673006160	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673006161	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673006162	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673006163	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673006164	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673006165	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673006166	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673006167	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673006168	active site
1036673006169	phosphorylation site [posttranslational modification]
1036673006170	intermolecular recognition site; other site
1036673006171	dimerization interface [polypeptide binding]; other site
1036673006172	LytTr DNA-binding domain; Region: LytTR; pfam04397
1036673006173	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673006174	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673006175	ATP binding site [chemical binding]; other site
1036673006176	Mg2+ binding site [ion binding]; other site
1036673006177	G-X-G motif; other site
1036673006178	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036673006179	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
1036673006180	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673006181	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1036673006182	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1036673006183	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673006184	DNA-binding site [nucleotide binding]; DNA binding site
1036673006185	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673006186	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673006187	homodimer interface [polypeptide binding]; other site
1036673006188	catalytic residue [active]
1036673006189	EamA-like transporter family; Region: EamA; pfam00892
1036673006190	EamA-like transporter family; Region: EamA; pfam00892
1036673006191	Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969
1036673006192	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673006193	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673006194	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673006195	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673006196	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673006197	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673006198	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1036673006199	NAD(P) binding site [chemical binding]; other site
1036673006200	active site
1036673006201	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1036673006202	conserved cys residue [active]
1036673006203	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673006204	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673006205	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721
1036673006206	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1036673006207	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036673006208	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673006209	S-adenosylmethionine binding site [chemical binding]; other site
1036673006210	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673006211	Coenzyme A binding pocket [chemical binding]; other site
1036673006212	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673006213	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673006214	NAD(P) binding site [chemical binding]; other site
1036673006215	active site
1036673006216	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1036673006217	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1036673006218	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1036673006219	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1036673006220	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1036673006221	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673006222	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673006223	S-layer homology domain; Region: SLH; pfam00395
1036673006224	S-layer homology domain; Region: SLH; pfam00395
1036673006225	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673006226	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673006227	active site
1036673006228	phosphorylation site [posttranslational modification]
1036673006229	intermolecular recognition site; other site
1036673006230	dimerization interface [polypeptide binding]; other site
1036673006231	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673006232	DNA binding site [nucleotide binding]
1036673006233	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673006234	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673006235	dimerization interface [polypeptide binding]; other site
1036673006236	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673006237	dimer interface [polypeptide binding]; other site
1036673006238	phosphorylation site [posttranslational modification]
1036673006239	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673006240	ATP binding site [chemical binding]; other site
1036673006241	Mg2+ binding site [ion binding]; other site
1036673006242	G-X-G motif; other site
1036673006243	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1036673006244	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
1036673006245	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1036673006246	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
1036673006247	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1036673006248	Helix-turn-helix domain; Region: HTH_31; pfam13560
1036673006249	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1036673006250	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
1036673006251	NADP binding site [chemical binding]; other site
1036673006252	substrate binding site [chemical binding]; other site
1036673006253	active site
1036673006254	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1036673006255	homotrimer interaction site [polypeptide binding]; other site
1036673006256	putative active site [active]
1036673006257	LysE type translocator; Region: LysE; cl00565
1036673006258	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673006259	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673006260	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673006261	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1036673006262	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1036673006263	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673006264	NAD(P) binding site [chemical binding]; other site
1036673006265	active site
1036673006266	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1036673006267	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1036673006268	DNA binding residues [nucleotide binding]
1036673006269	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673006270	short chain dehydrogenase; Provisional; Region: PRK07454
1036673006271	NAD(P) binding site [chemical binding]; other site
1036673006272	active site
1036673006273	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1036673006274	nudix motif; other site
1036673006275	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1036673006276	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673006277	EamA-like transporter family; Region: EamA; pfam00892
1036673006278	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1036673006279	EamA-like transporter family; Region: EamA; cl17759
1036673006280	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
1036673006281	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1036673006282	MOSC domain; Region: MOSC; pfam03473
1036673006283	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
1036673006284	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673006285	putative homodimer interface [polypeptide binding]; other site
1036673006286	Sm and related proteins; Region: Sm_like; cl00259
1036673006287	heptamer interface [polypeptide binding]; other site
1036673006288	Sm1 motif; other site
1036673006289	hexamer interface [polypeptide binding]; other site
1036673006290	RNA binding site [nucleotide binding]; other site
1036673006291	Sm2 motif; other site
1036673006292	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
1036673006293	Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404
1036673006294	DHH family; Region: DHH; pfam01368
1036673006295	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673006296	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673006297	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673006298	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673006299	putative substrate translocation pore; other site
1036673006300	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1036673006301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673006302	active site
1036673006303	phosphorylation site [posttranslational modification]
1036673006304	intermolecular recognition site; other site
1036673006305	dimerization interface [polypeptide binding]; other site
1036673006306	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1036673006307	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673006308	ATP binding site [chemical binding]; other site
1036673006309	Mg2+ binding site [ion binding]; other site
1036673006310	G-X-G motif; other site
1036673006311	H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851
1036673006312	Citrate transporter; Region: CitMHS; pfam03600
1036673006313	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1036673006314	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
1036673006315	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1036673006316	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1036673006317	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1036673006318	active site
1036673006319	substrate-binding site [chemical binding]; other site
1036673006320	metal-binding site [ion binding]
1036673006321	ATP binding site [chemical binding]; other site
1036673006322	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1036673006323	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673006324	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673006325	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673006326	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673006327	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673006328	DNA binding site [nucleotide binding]
1036673006329	domain linker motif; other site
1036673006330	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673006331	dimerization interface [polypeptide binding]; other site
1036673006332	ligand binding site [chemical binding]; other site
1036673006333	High-affinity nickel-transport protein; Region: NicO; cl00964
1036673006334	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673006335	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673006336	dimerization interface [polypeptide binding]; other site
1036673006337	Histidine kinase; Region: His_kinase; pfam06580
1036673006338	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673006339	ATP binding site [chemical binding]; other site
1036673006340	Mg2+ binding site [ion binding]; other site
1036673006341	G-X-G motif; other site
1036673006342	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673006343	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673006344	active site
1036673006345	phosphorylation site [posttranslational modification]
1036673006346	intermolecular recognition site; other site
1036673006347	dimerization interface [polypeptide binding]; other site
1036673006348	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673006349	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673006350	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673006351	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673006352	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673006353	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673006354	dimer interface [polypeptide binding]; other site
1036673006355	conserved gate region; other site
1036673006356	putative PBP binding loops; other site
1036673006357	ABC-ATPase subunit interface; other site
1036673006358	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673006359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673006360	dimer interface [polypeptide binding]; other site
1036673006361	conserved gate region; other site
1036673006362	putative PBP binding loops; other site
1036673006363	ABC-ATPase subunit interface; other site
1036673006364	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1036673006365	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1036673006366	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1036673006367	PAS domain; Region: PAS; smart00091
1036673006368	PAS domain; Region: PAS_9; pfam13426
1036673006369	putative active site [active]
1036673006370	heme pocket [chemical binding]; other site
1036673006371	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673006372	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673006373	metal binding site [ion binding]; metal-binding site
1036673006374	active site
1036673006375	I-site; other site
1036673006376	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673006377	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1036673006378	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1036673006379	dimer interface [polypeptide binding]; other site
1036673006380	PYR/PP interface [polypeptide binding]; other site
1036673006381	TPP binding site [chemical binding]; other site
1036673006382	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1036673006383	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1036673006384	TPP-binding site [chemical binding]; other site
1036673006385	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1036673006386	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1036673006387	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1036673006388	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1036673006389	PYR/PP interface [polypeptide binding]; other site
1036673006390	dimer interface [polypeptide binding]; other site
1036673006391	TPP binding site [chemical binding]; other site
1036673006392	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1036673006393	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1036673006394	TPP-binding site [chemical binding]; other site
1036673006395	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1036673006396	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673006397	putative active site [active]
1036673006398	heme pocket [chemical binding]; other site
1036673006399	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673006400	dimer interface [polypeptide binding]; other site
1036673006401	phosphorylation site [posttranslational modification]
1036673006402	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673006403	ATP binding site [chemical binding]; other site
1036673006404	Mg2+ binding site [ion binding]; other site
1036673006405	G-X-G motif; other site
1036673006406	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1036673006407	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1036673006408	Walker A/P-loop; other site
1036673006409	ATP binding site [chemical binding]; other site
1036673006410	Q-loop/lid; other site
1036673006411	ABC transporter signature motif; other site
1036673006412	Walker B; other site
1036673006413	D-loop; other site
1036673006414	H-loop/switch region; other site
1036673006415	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036673006416	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673006417	dimer interface [polypeptide binding]; other site
1036673006418	conserved gate region; other site
1036673006419	putative PBP binding loops; other site
1036673006420	ABC-ATPase subunit interface; other site
1036673006421	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036673006422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673006423	dimer interface [polypeptide binding]; other site
1036673006424	conserved gate region; other site
1036673006425	putative PBP binding loops; other site
1036673006426	ABC-ATPase subunit interface; other site
1036673006427	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1036673006428	NMT1/THI5 like; Region: NMT1; pfam09084
1036673006429	aminotransferase; Validated; Region: PRK07678
1036673006430	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036673006431	inhibitor-cofactor binding pocket; inhibition site
1036673006432	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673006433	catalytic residue [active]
1036673006434	allantoate amidohydrolase; Reviewed; Region: PRK09290
1036673006435	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1036673006436	active site
1036673006437	metal binding site [ion binding]; metal-binding site
1036673006438	dimer interface [polypeptide binding]; other site
1036673006439	mammalian-like beta-alanine synthase (beta-AS) and similar proteins (class 5 nitrilases); Region: ML_beta-AS_like; cd07568
1036673006440	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
1036673006441	putative active site [active]
1036673006442	catalytic triad [active]
1036673006443	multimer interface [polypeptide binding]; other site
1036673006444	dimer interface [polypeptide binding]; other site
1036673006445	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
1036673006446	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036673006447	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036673006448	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
1036673006449	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
1036673006450	homodimer interface [polypeptide binding]; other site
1036673006451	active site
1036673006452	FMN binding site [chemical binding]; other site
1036673006453	substrate binding site [chemical binding]; other site
1036673006454	4Fe-4S binding domain; Region: Fer4; pfam00037
1036673006455	phenylhydantoinase; Validated; Region: PRK08323
1036673006456	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
1036673006457	tetramer interface [polypeptide binding]; other site
1036673006458	active site
1036673006459	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1036673006460	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1036673006461	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1036673006462	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1036673006463	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1036673006464	NAD(P) binding site [chemical binding]; other site
1036673006465	catalytic residues [active]
1036673006466	ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144
1036673006467	Cache domain; Region: Cache_1; pfam02743
1036673006468	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673006469	dimerization interface [polypeptide binding]; other site
1036673006470	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673006471	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673006472	dimer interface [polypeptide binding]; other site
1036673006473	putative CheW interface [polypeptide binding]; other site
1036673006474	Predicted transcriptional regulators [Transcription]; Region: COG1695
1036673006475	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673006476	putative DNA binding site [nucleotide binding]; other site
1036673006477	putative Zn2+ binding site [ion binding]; other site
1036673006478	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
1036673006479	substrate binding site [chemical binding]; other site
1036673006480	active site
1036673006481	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1036673006482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673006483	S-adenosylmethionine binding site [chemical binding]; other site
1036673006484	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1036673006485	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1036673006486	DNA binding residues [nucleotide binding]
1036673006487	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1036673006488	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673006489	S-adenosylmethionine binding site [chemical binding]; other site
1036673006490	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673006491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673006492	dimer interface [polypeptide binding]; other site
1036673006493	conserved gate region; other site
1036673006494	putative PBP binding loops; other site
1036673006495	ABC-ATPase subunit interface; other site
1036673006496	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673006497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673006498	dimer interface [polypeptide binding]; other site
1036673006499	conserved gate region; other site
1036673006500	putative PBP binding loops; other site
1036673006501	ABC-ATPase subunit interface; other site
1036673006502	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673006503	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673006504	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1036673006505	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673006506	active site
1036673006507	phosphorylation site [posttranslational modification]
1036673006508	intermolecular recognition site; other site
1036673006509	dimerization interface [polypeptide binding]; other site
1036673006510	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673006511	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673006512	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673006513	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673006514	dimerization interface [polypeptide binding]; other site
1036673006515	Histidine kinase; Region: His_kinase; pfam06580
1036673006516	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673006517	ATP binding site [chemical binding]; other site
1036673006518	Mg2+ binding site [ion binding]; other site
1036673006519	G-X-G motif; other site
1036673006520	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673006521	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673006522	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673006523	dimerization interface [polypeptide binding]; other site
1036673006524	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1036673006525	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1036673006526	homodimer interface [polypeptide binding]; other site
1036673006527	substrate-cofactor binding pocket; other site
1036673006528	catalytic residue [active]
1036673006529	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673006530	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248
1036673006531	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1036673006532	homodimer interface [polypeptide binding]; other site
1036673006533	substrate-cofactor binding pocket; other site
1036673006534	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673006535	catalytic residue [active]
1036673006536	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673006537	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1036673006538	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1036673006539	Walker A/P-loop; other site
1036673006540	ATP binding site [chemical binding]; other site
1036673006541	Q-loop/lid; other site
1036673006542	ABC transporter signature motif; other site
1036673006543	Walker B; other site
1036673006544	D-loop; other site
1036673006545	H-loop/switch region; other site
1036673006546	Predicted transcriptional regulators [Transcription]; Region: COG1725
1036673006547	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673006548	DNA-binding site [nucleotide binding]; DNA binding site
1036673006549	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1036673006550	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036673006551	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1036673006552	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1036673006553	dimanganese center [ion binding]; other site
1036673006554	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1036673006555	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1036673006556	active site
1036673006557	Pirin-related protein [General function prediction only]; Region: COG1741
1036673006558	Pirin; Region: Pirin; pfam02678
1036673006559	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1036673006560	Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794
1036673006561	aspartate racemase; Region: asp_race; TIGR00035
1036673006562	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673006563	Spore germination protein; Region: Spore_permease; cl17796
1036673006564	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673006565	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673006566	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1036673006567	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673006568	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673006569	dimer interface [polypeptide binding]; other site
1036673006570	phosphorylation site [posttranslational modification]
1036673006571	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673006572	ATP binding site [chemical binding]; other site
1036673006573	Mg2+ binding site [ion binding]; other site
1036673006574	G-X-G motif; other site
1036673006575	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673006576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673006577	active site
1036673006578	phosphorylation site [posttranslational modification]
1036673006579	intermolecular recognition site; other site
1036673006580	dimerization interface [polypeptide binding]; other site
1036673006581	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1036673006582	Histidine kinase; Region: HisKA_3; pfam07730
1036673006583	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673006584	ATP binding site [chemical binding]; other site
1036673006585	Mg2+ binding site [ion binding]; other site
1036673006586	G-X-G motif; other site
1036673006587	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673006588	dimerization interface [polypeptide binding]; other site
1036673006589	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673006590	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673006591	dimer interface [polypeptide binding]; other site
1036673006592	putative CheW interface [polypeptide binding]; other site
1036673006593	L-arabinose isomerase; Provisional; Region: PRK02929
1036673006594	L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557
1036673006595	putative hexamer (dimer of trimers) interface [polypeptide binding]; other site
1036673006596	trimer interface [polypeptide binding]; other site
1036673006597	putative substrate binding site [chemical binding]; other site
1036673006598	putative metal binding site [ion binding]; other site
1036673006599	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
1036673006600	active site
1036673006601	catalytic residues [active]
1036673006602	Domain of unknown function (DUF4385); Region: DUF4385; pfam14328
1036673006603	Domain of unknown function (DUF4182); Region: DUF4182; pfam13790
1036673006604	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
1036673006605	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673006606	Cache domain; Region: Cache_1; pfam02743
1036673006607	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673006608	dimerization interface [polypeptide binding]; other site
1036673006609	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673006610	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673006611	dimer interface [polypeptide binding]; other site
1036673006612	putative CheW interface [polypeptide binding]; other site
1036673006613	Clp protease; Region: CLP_protease; pfam00574
1036673006614	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1036673006615	oligomer interface [polypeptide binding]; other site
1036673006616	active site residues [active]
1036673006617	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673006618	putative DNA binding site [nucleotide binding]; other site
1036673006619	putative Zn2+ binding site [ion binding]; other site
1036673006620	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1036673006621	G-X-G motif; other site
1036673006622	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1036673006623	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488
1036673006624	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673006625	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673006626	Initiator Replication protein; Region: Rep_3; pfam01051
1036673006627	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673006628	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673006629	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1036673006630	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1036673006631	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1036673006632	beta-galactosidase; Region: BGL; TIGR03356
1036673006633	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673006634	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673006635	DNA binding site [nucleotide binding]
1036673006636	domain linker motif; other site
1036673006637	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1036673006638	putative dimerization interface [polypeptide binding]; other site
1036673006639	putative ligand binding site [chemical binding]; other site
1036673006640	DoxX; Region: DoxX; cl17842
1036673006641	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673006642	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673006643	Alginate lyase; Region: Alginate_lyase; pfam05426
1036673006644	Bacterial SH3 domain; Region: SH3_3; pfam08239
1036673006645	Bacterial SH3 domain; Region: SH3_3; pfam08239
1036673006646	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1036673006647	NlpC/P60 family; Region: NLPC_P60; pfam00877
1036673006648	hypothetical protein; Provisional; Region: PRK02237
1036673006649	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1036673006650	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
1036673006651	putative ligand binding site [chemical binding]; other site
1036673006652	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1036673006653	HAMP domain; Region: HAMP; pfam00672
1036673006654	dimerization interface [polypeptide binding]; other site
1036673006655	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673006656	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673006657	dimer interface [polypeptide binding]; other site
1036673006658	putative CheW interface [polypeptide binding]; other site
1036673006659	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1036673006660	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1036673006661	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1036673006662	PAS domain S-box; Region: sensory_box; TIGR00229
1036673006663	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673006664	putative active site [active]
1036673006665	heme pocket [chemical binding]; other site
1036673006666	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673006667	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673006668	metal binding site [ion binding]; metal-binding site
1036673006669	active site
1036673006670	I-site; other site
1036673006671	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673006672	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673006673	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673006674	DNA binding site [nucleotide binding]
1036673006675	domain linker motif; other site
1036673006676	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673006677	dimerization interface [polypeptide binding]; other site
1036673006678	ligand binding site [chemical binding]; other site
1036673006679	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673006680	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673006681	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673006682	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673006683	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673006684	active site
1036673006685	phosphorylation site [posttranslational modification]
1036673006686	intermolecular recognition site; other site
1036673006687	dimerization interface [polypeptide binding]; other site
1036673006688	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1036673006689	metal-dependent hydrolase; Provisional; Region: PRK00685
1036673006690	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673006691	Coenzyme A binding pocket [chemical binding]; other site
1036673006692	PAS domain S-box; Region: sensory_box; TIGR00229
1036673006693	PAS domain; Region: PAS; smart00091
1036673006694	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673006695	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673006696	metal binding site [ion binding]; metal-binding site
1036673006697	active site
1036673006698	I-site; other site
1036673006699	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673006700	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
1036673006701	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673006702	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673006703	Walker A/P-loop; other site
1036673006704	ATP binding site [chemical binding]; other site
1036673006705	Q-loop/lid; other site
1036673006706	ABC transporter signature motif; other site
1036673006707	Walker B; other site
1036673006708	D-loop; other site
1036673006709	H-loop/switch region; other site
1036673006710	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673006711	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673006712	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673006713	Walker A/P-loop; other site
1036673006714	ATP binding site [chemical binding]; other site
1036673006715	Q-loop/lid; other site
1036673006716	ABC transporter signature motif; other site
1036673006717	Walker B; other site
1036673006718	D-loop; other site
1036673006719	H-loop/switch region; other site
1036673006720	histidyl-tRNA synthetase; Region: hisS; TIGR00442
1036673006721	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1036673006722	dimer interface [polypeptide binding]; other site
1036673006723	motif 1; other site
1036673006724	active site
1036673006725	motif 2; other site
1036673006726	motif 3; other site
1036673006727	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1036673006728	anticodon binding site; other site
1036673006729	Sulfatase; Region: Sulfatase; pfam00884
1036673006730	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
1036673006731	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
1036673006732	GIY-YIG motif/motif A; other site
1036673006733	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1036673006734	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1036673006735	phosphopeptide binding site; other site
1036673006736	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673006737	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673006738	DNA binding site [nucleotide binding]
1036673006739	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1036673006740	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1036673006741	hinge; other site
1036673006742	active site
1036673006743	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1036673006744	active site
1036673006745	multimer interface [polypeptide binding]; other site
1036673006746	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673006747	non-specific DNA binding site [nucleotide binding]; other site
1036673006748	salt bridge; other site
1036673006749	sequence-specific DNA binding site [nucleotide binding]; other site
1036673006750	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1036673006751	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1036673006752	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673006753	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673006754	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036673006755	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673006756	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673006757	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673006758	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673006759	membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082
1036673006760	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
1036673006761	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673006762	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1036673006763	putative dimerization interface [polypeptide binding]; other site
1036673006764	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
1036673006765	fructuronate transporter; Provisional; Region: PRK10034; cl15264
1036673006766	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1036673006767	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673006768	NAD(P) binding site [chemical binding]; other site
1036673006769	active site
1036673006770	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1036673006771	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1036673006772	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1036673006773	dimer interface [polypeptide binding]; other site
1036673006774	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1036673006775	active site
1036673006776	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1036673006777	Cytochrome P450; Region: p450; cl12078
1036673006778	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1036673006779	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1036673006780	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1036673006781	Mg++ binding site [ion binding]; other site
1036673006782	putative catalytic motif [active]
1036673006783	substrate binding site [chemical binding]; other site
1036673006784	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673006785	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673006786	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673006787	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673006788	Domain of unknown function (DUF3817); Region: DUF3817; pfam12823
1036673006789	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1036673006790	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1036673006791	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673006792	dimer interface [polypeptide binding]; other site
1036673006793	conserved gate region; other site
1036673006794	ABC-ATPase subunit interface; other site
1036673006795	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1036673006796	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1036673006797	Walker A/P-loop; other site
1036673006798	ATP binding site [chemical binding]; other site
1036673006799	Q-loop/lid; other site
1036673006800	ABC transporter signature motif; other site
1036673006801	Walker B; other site
1036673006802	D-loop; other site
1036673006803	H-loop/switch region; other site
1036673006804	selenophosphate synthetase; Provisional; Region: PRK00943
1036673006805	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1036673006806	dimerization interface [polypeptide binding]; other site
1036673006807	putative ATP binding site [chemical binding]; other site
1036673006808	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
1036673006809	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1036673006810	active site residue [active]
1036673006811	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673006812	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673006813	ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091
1036673006814	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1036673006815	NAD(P) binding site [chemical binding]; other site
1036673006816	catalytic residues [active]
1036673006817	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
1036673006818	short chain dehydrogenase; Provisional; Region: PRK06701
1036673006819	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1036673006820	NAD binding site [chemical binding]; other site
1036673006821	metal binding site [ion binding]; metal-binding site
1036673006822	active site
1036673006823	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1036673006824	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036673006825	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1036673006826	Membrane Fusion Protein cluster 2 (function with RND porters); Region: 8a0102; TIGR00999
1036673006827	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036673006828	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036673006829	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036673006830	Walker A/P-loop; other site
1036673006831	ATP binding site [chemical binding]; other site
1036673006832	Q-loop/lid; other site
1036673006833	ABC transporter signature motif; other site
1036673006834	Walker B; other site
1036673006835	D-loop; other site
1036673006836	H-loop/switch region; other site
1036673006837	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1036673006838	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1036673006839	FtsX-like permease family; Region: FtsX; pfam02687
1036673006840	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1036673006841	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1036673006842	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1036673006843	Chromate transporter; Region: Chromate_transp; pfam02417
1036673006844	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673006845	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673006846	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1036673006847	zinc binding site [ion binding]; other site
1036673006848	putative ligand binding site [chemical binding]; other site
1036673006849	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673006850	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1036673006851	TM-ABC transporter signature motif; other site
1036673006852	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1036673006853	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673006854	Walker A/P-loop; other site
1036673006855	ATP binding site [chemical binding]; other site
1036673006856	Q-loop/lid; other site
1036673006857	ABC transporter signature motif; other site
1036673006858	Walker B; other site
1036673006859	D-loop; other site
1036673006860	H-loop/switch region; other site
1036673006861	Protein of unknown function (DUF3889); Region: DUF3889; pfam13028
1036673006862	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673006863	dimerization interface [polypeptide binding]; other site
1036673006864	putative DNA binding site [nucleotide binding]; other site
1036673006865	putative Zn2+ binding site [ion binding]; other site
1036673006866	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
1036673006867	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1036673006868	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1036673006869	active site
1036673006870	Protein of unknown function (DUF962); Region: DUF962; pfam06127
1036673006871	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1036673006872	rod shape-determining protein MreB; Provisional; Region: PRK13927
1036673006873	MreB and similar proteins; Region: MreB_like; cd10225
1036673006874	nucleotide binding site [chemical binding]; other site
1036673006875	Mg binding site [ion binding]; other site
1036673006876	putative protofilament interaction site [polypeptide binding]; other site
1036673006877	RodZ interaction site [polypeptide binding]; other site
1036673006878	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673006879	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1036673006880	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673006881	dimer interface [polypeptide binding]; other site
1036673006882	phosphorylation site [posttranslational modification]
1036673006883	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673006884	ATP binding site [chemical binding]; other site
1036673006885	Mg2+ binding site [ion binding]; other site
1036673006886	G-X-G motif; other site
1036673006887	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673006888	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673006889	active site
1036673006890	phosphorylation site [posttranslational modification]
1036673006891	intermolecular recognition site; other site
1036673006892	dimerization interface [polypeptide binding]; other site
1036673006893	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673006894	DNA binding site [nucleotide binding]
1036673006895	Haemolytic domain; Region: Haemolytic; pfam01809
1036673006896	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1036673006897	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1036673006898	active site
1036673006899	HIGH motif; other site
1036673006900	KMSKS motif; other site
1036673006901	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1036673006902	tRNA binding surface [nucleotide binding]; other site
1036673006903	anticodon binding site; other site
1036673006904	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1036673006905	dimer interface [polypeptide binding]; other site
1036673006906	putative tRNA-binding site [nucleotide binding]; other site
1036673006907	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673006908	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673006909	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673006910	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
1036673006911	glycogen binding site [chemical binding]; other site
1036673006912	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1036673006913	active site
1036673006914	catalytic site [active]
1036673006915	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
1036673006916	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1036673006917	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1036673006918	metal binding site [ion binding]; metal-binding site
1036673006919	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036673006920	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1036673006921	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1036673006922	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673006923	ABC-ATPase subunit  interface; other site
1036673006924	dimer interface [polypeptide binding]; other site
1036673006925	putative PBP binding regions; other site
1036673006926	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1036673006927	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1036673006928	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1036673006929	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673006930	FeS/SAM binding site; other site
1036673006931	manganese transport transcriptional regulator; Provisional; Region: PRK03902
1036673006932	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1036673006933	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1036673006934	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
1036673006935	active site
1036673006936	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1036673006937	nucleophile elbow; other site
1036673006938	Protein of unknown function (DUF1385); Region: DUF1385; cl01595
1036673006939	Conserved membrane protein YqhR; Region: YqhR; pfam11085
1036673006940	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1036673006941	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1036673006942	trimer interface [polypeptide binding]; other site
1036673006943	active site
1036673006944	dimer interface [polypeptide binding]; other site
1036673006945	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1036673006946	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1036673006947	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1036673006948	active site
1036673006949	elongation factor P; Validated; Region: PRK00529
1036673006950	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1036673006951	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1036673006952	RNA binding site [nucleotide binding]; other site
1036673006953	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1036673006954	RNA binding site [nucleotide binding]; other site
1036673006955	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1036673006956	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673006957	DNA-binding site [nucleotide binding]; DNA binding site
1036673006958	DRTGG domain; Region: DRTGG; pfam07085
1036673006959	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1036673006960	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1036673006961	active site 2 [active]
1036673006962	active site 1 [active]
1036673006963	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
1036673006964	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1036673006965	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673006966	motif II; other site
1036673006967	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1036673006968	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
1036673006969	aspartate kinase; Reviewed; Region: PRK06635
1036673006970	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1036673006971	putative nucleotide binding site [chemical binding]; other site
1036673006972	putative catalytic residues [active]
1036673006973	putative Mg ion binding site [ion binding]; other site
1036673006974	putative aspartate binding site [chemical binding]; other site
1036673006975	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1036673006976	putative allosteric regulatory site; other site
1036673006977	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1036673006978	Protein of unknown function (DUF441); Region: DUF441; pfam04284
1036673006979	Phosphosulfolactate phosphohydrolase and related enzymes [Coenzyme metabolism / General function prediction only]; Region: COG2045
1036673006980	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
1036673006981	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679
1036673006982	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
1036673006983	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
1036673006984	NTPase; Region: NTPase_1; cl17478
1036673006985	Stage III sporulation protein AB (spore_III_AB); Region: Spore_III_AB; cl08022
1036673006986	Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961
1036673006987	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
1036673006988	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546
1036673006989	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
1036673006990	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
1036673006991	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
1036673006992	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1036673006993	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1036673006994	carboxyltransferase (CT) interaction site; other site
1036673006995	biotinylation site [posttranslational modification]; other site
1036673006996	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1036673006997	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1036673006998	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1036673006999	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1036673007000	Asp23 family; Region: Asp23; pfam03780
1036673007001	Asp23 family; Region: Asp23; pfam03780
1036673007002	Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031
1036673007003	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
1036673007004	putative RNA binding site [nucleotide binding]; other site
1036673007005	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
1036673007006	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1036673007007	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1036673007008	homodimer interface [polypeptide binding]; other site
1036673007009	NADP binding site [chemical binding]; other site
1036673007010	substrate binding site [chemical binding]; other site
1036673007011	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1036673007012	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1036673007013	generic binding surface II; other site
1036673007014	generic binding surface I; other site
1036673007015	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1036673007016	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1036673007017	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1036673007018	substrate binding pocket [chemical binding]; other site
1036673007019	chain length determination region; other site
1036673007020	substrate-Mg2+ binding site; other site
1036673007021	catalytic residues [active]
1036673007022	aspartate-rich region 1; other site
1036673007023	active site lid residues [active]
1036673007024	aspartate-rich region 2; other site
1036673007025	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1036673007026	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1036673007027	TPP-binding site; other site
1036673007028	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1036673007029	PYR/PP interface [polypeptide binding]; other site
1036673007030	dimer interface [polypeptide binding]; other site
1036673007031	TPP binding site [chemical binding]; other site
1036673007032	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1036673007033	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1036673007034	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036673007035	RNA binding surface [nucleotide binding]; other site
1036673007036	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1036673007037	arginine repressor; Provisional; Region: PRK04280
1036673007038	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1036673007039	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1036673007040	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1036673007041	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1036673007042	Walker A/P-loop; other site
1036673007043	ATP binding site [chemical binding]; other site
1036673007044	Q-loop/lid; other site
1036673007045	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1036673007046	Q-loop/lid; other site
1036673007047	ABC transporter signature motif; other site
1036673007048	Walker B; other site
1036673007049	D-loop; other site
1036673007050	H-loop/switch region; other site
1036673007051	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
1036673007052	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1036673007053	protein binding site [polypeptide binding]; other site
1036673007054	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
1036673007055	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
1036673007056	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673007057	active site
1036673007058	phosphorylation site [posttranslational modification]
1036673007059	intermolecular recognition site; other site
1036673007060	dimerization interface [polypeptide binding]; other site
1036673007061	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
1036673007062	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1036673007063	Protein of unknown function (DUF2627); Region: DUF2627; pfam11118
1036673007064	dihydrolipoamide dehydrogenase; Validated; Region: PRK05976
1036673007065	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036673007066	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1036673007067	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1036673007068	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1036673007069	tetramer interface [polypeptide binding]; other site
1036673007070	TPP-binding site [chemical binding]; other site
1036673007071	heterodimer interface [polypeptide binding]; other site
1036673007072	phosphorylation loop region [posttranslational modification]
1036673007073	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1036673007074	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1036673007075	alpha subunit interface [polypeptide binding]; other site
1036673007076	TPP binding site [chemical binding]; other site
1036673007077	heterodimer interface [polypeptide binding]; other site
1036673007078	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1036673007079	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1036673007080	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1036673007081	E3 interaction surface; other site
1036673007082	lipoyl attachment site [posttranslational modification]; other site
1036673007083	e3 binding domain; Region: E3_binding; pfam02817
1036673007084	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1036673007085	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
1036673007086	peptidase T-like protein; Region: PepT-like; TIGR01883
1036673007087	metal binding site [ion binding]; metal-binding site
1036673007088	putative dimer interface [polypeptide binding]; other site
1036673007089	Protein of unknown function (DUF3936); Region: DUF3936; pfam13072
1036673007090	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1036673007091	dimer interface [polypeptide binding]; other site
1036673007092	ADP-ribose binding site [chemical binding]; other site
1036673007093	active site
1036673007094	nudix motif; other site
1036673007095	metal binding site [ion binding]; metal-binding site
1036673007096	PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379
1036673007097	PHP-associated; Region: PHP_C; pfam13263
1036673007098	Integral membrane protein DUF95; Region: DUF95; cl00572
1036673007099	ferric uptake regulator; Provisional; Region: fur; PRK09462
1036673007100	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1036673007101	metal binding site 2 [ion binding]; metal-binding site
1036673007102	putative DNA binding helix; other site
1036673007103	metal binding site 1 [ion binding]; metal-binding site
1036673007104	dimer interface [polypeptide binding]; other site
1036673007105	structural Zn2+ binding site [ion binding]; other site
1036673007106	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1036673007107	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1036673007108	hexamer interface [polypeptide binding]; other site
1036673007109	ligand binding site [chemical binding]; other site
1036673007110	putative active site [active]
1036673007111	NAD(P) binding site [chemical binding]; other site
1036673007112	Protein of unknown function (DUF4227); Region: DUF4227; pfam14004
1036673007113	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
1036673007114	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
1036673007115	active site
1036673007116	Int/Topo IB signature motif; other site
1036673007117	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1036673007118	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1036673007119	flagellar operon protein TIGR03826; Region: YvyF
1036673007120	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1036673007121	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1036673007122	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1036673007123	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1036673007124	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
1036673007125	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1036673007126	anti sigma factor interaction site; other site
1036673007127	regulatory phosphorylation site [posttranslational modification]; other site
1036673007128	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1036673007129	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673007130	ATP binding site [chemical binding]; other site
1036673007131	Mg2+ binding site [ion binding]; other site
1036673007132	G-X-G motif; other site
1036673007133	sporulation sigma factor SigF; Validated; Region: PRK05572
1036673007134	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673007135	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1036673007136	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673007137	DNA binding residues [nucleotide binding]
1036673007138	Domain of unknown function (DUF378); Region: DUF378; pfam04070
1036673007139	Stage V sporulation protein AA; Region: SporV_AA; pfam12164
1036673007140	Stage V sporulation protein AB; Region: SpoVAB; pfam13782
1036673007141	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673007142	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1036673007143	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1036673007144	active site
1036673007145	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1036673007146	substrate binding site [chemical binding]; other site
1036673007147	catalytic residues [active]
1036673007148	dimer interface [polypeptide binding]; other site
1036673007149	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1036673007150	active site
1036673007151	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1036673007152	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1036673007153	catalytic motif [active]
1036673007154	Zn binding site [ion binding]; other site
1036673007155	RibD C-terminal domain; Region: RibD_C; cl17279
1036673007156	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1036673007157	Lumazine binding domain; Region: Lum_binding; pfam00677
1036673007158	Lumazine binding domain; Region: Lum_binding; pfam00677
1036673007159	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
1036673007160	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1036673007161	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1036673007162	dimerization interface [polypeptide binding]; other site
1036673007163	active site
1036673007164	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1036673007165	homopentamer interface [polypeptide binding]; other site
1036673007166	active site
1036673007167	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1036673007168	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
1036673007169	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
1036673007170	sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874
1036673007171	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1036673007172	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1036673007173	PAS domain S-box; Region: sensory_box; TIGR00229
1036673007174	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673007175	putative active site [active]
1036673007176	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673007177	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673007178	metal binding site [ion binding]; metal-binding site
1036673007179	active site
1036673007180	I-site; other site
1036673007181	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673007182	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
1036673007183	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1036673007184	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1036673007185	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
1036673007186	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
1036673007187	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
1036673007188	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1036673007189	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036673007190	RNA binding surface [nucleotide binding]; other site
1036673007191	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1036673007192	active site
1036673007193	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1036673007194	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1036673007195	catalytic residues [active]
1036673007196	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
1036673007197	ResB-like family; Region: ResB; pfam05140
1036673007198	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1036673007199	cytochrome c-type biogenesis protein CcsB; Region: cytochr_II_ccsB; TIGR03144
1036673007200	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673007201	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673007202	active site
1036673007203	phosphorylation site [posttranslational modification]
1036673007204	intermolecular recognition site; other site
1036673007205	dimerization interface [polypeptide binding]; other site
1036673007206	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673007207	DNA binding site [nucleotide binding]
1036673007208	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673007209	dimerization interface [polypeptide binding]; other site
1036673007210	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1036673007211	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673007212	dimer interface [polypeptide binding]; other site
1036673007213	phosphorylation site [posttranslational modification]
1036673007214	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673007215	ATP binding site [chemical binding]; other site
1036673007216	Mg2+ binding site [ion binding]; other site
1036673007217	G-X-G motif; other site
1036673007218	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1036673007219	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1036673007220	ligand binding site [chemical binding]; other site
1036673007221	NAD binding site [chemical binding]; other site
1036673007222	dimerization interface [polypeptide binding]; other site
1036673007223	catalytic site [active]
1036673007224	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1036673007225	putative L-serine binding site [chemical binding]; other site
1036673007226	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1036673007227	active site residue [active]
1036673007228	CAAX protease self-immunity; Region: Abi; pfam02517
1036673007229	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1036673007230	NodB motif; other site
1036673007231	active site
1036673007232	catalytic site [active]
1036673007233	metal binding site [ion binding]; metal-binding site
1036673007234	Negative regulator of genetic competence (MecA); Region: MecA; cl02022
1036673007235	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1036673007236	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
1036673007237	active site
1036673007238	interdomain interaction site; other site
1036673007239	metal binding site [ion binding]; metal-binding site
1036673007240	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
1036673007241	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1036673007242	Walker A motif; other site
1036673007243	ATP binding site [chemical binding]; other site
1036673007244	Walker B motif; other site
1036673007245	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1036673007246	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1036673007247	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1036673007248	NAD(P) binding site [chemical binding]; other site
1036673007249	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1036673007250	germination protein YpeB; Region: spore_YpeB; TIGR02889
1036673007251	Flagellar protein YcgR; Region: YcgR_2; pfam12945
1036673007252	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
1036673007253	PilZ domain; Region: PilZ; pfam07238
1036673007254	cytidylate kinase; Provisional; Region: cmk; PRK00023
1036673007255	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1036673007256	CMP-binding site; other site
1036673007257	The sites determining sugar specificity; other site
1036673007258	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1036673007259	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1036673007260	putative acyl-acceptor binding pocket; other site
1036673007261	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1036673007262	RNA binding site [nucleotide binding]; other site
1036673007263	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1036673007264	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1036673007265	RNA binding site [nucleotide binding]; other site
1036673007266	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1036673007267	RNA binding site [nucleotide binding]; other site
1036673007268	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1036673007269	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1036673007270	homotetramer interface [polypeptide binding]; other site
1036673007271	FMN binding site [chemical binding]; other site
1036673007272	homodimer contacts [polypeptide binding]; other site
1036673007273	putative active site [active]
1036673007274	putative substrate binding site [chemical binding]; other site
1036673007275	YIEGIA protein; Region: YIEGIA; pfam14045
1036673007276	GTP-binding protein Der; Reviewed; Region: PRK00093
1036673007277	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1036673007278	G1 box; other site
1036673007279	GTP/Mg2+ binding site [chemical binding]; other site
1036673007280	Switch I region; other site
1036673007281	G2 box; other site
1036673007282	Switch II region; other site
1036673007283	G3 box; other site
1036673007284	G4 box; other site
1036673007285	G5 box; other site
1036673007286	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1036673007287	G1 box; other site
1036673007288	GTP/Mg2+ binding site [chemical binding]; other site
1036673007289	Switch I region; other site
1036673007290	G2 box; other site
1036673007291	G3 box; other site
1036673007292	Switch II region; other site
1036673007293	G4 box; other site
1036673007294	G5 box; other site
1036673007295	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
1036673007296	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1036673007297	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1036673007298	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1036673007299	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
1036673007300	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1036673007301	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1036673007302	catalytic loop [active]
1036673007303	iron binding site [ion binding]; other site
1036673007304	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1036673007305	metal binding triad [ion binding]; metal-binding site
1036673007306	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1036673007307	catalytic loop [active]
1036673007308	iron binding site [ion binding]; other site
1036673007309	Protein of unknown function (DUF3939); Region: DUF3939; pfam13075
1036673007310	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
1036673007311	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1036673007312	G1 box; other site
1036673007313	GTP/Mg2+ binding site [chemical binding]; other site
1036673007314	G2 box; other site
1036673007315	Switch I region; other site
1036673007316	G3 box; other site
1036673007317	Switch II region; other site
1036673007318	G5 box; other site
1036673007319	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1036673007320	IHF - DNA interface [nucleotide binding]; other site
1036673007321	IHF dimer interface [polypeptide binding]; other site
1036673007322	transcription attenuation protein MtrB; Provisional; Region: PRK13251
1036673007323	Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307
1036673007324	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
1036673007325	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673007326	S-adenosylmethionine binding site [chemical binding]; other site
1036673007327	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
1036673007328	UbiA prenyltransferase family; Region: UbiA; pfam01040
1036673007329	aromatic acid decarboxylase; Validated; Region: PRK05920
1036673007330	Flavoprotein; Region: Flavoprotein; pfam02441
1036673007331	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1036673007332	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1036673007333	substrate binding pocket [chemical binding]; other site
1036673007334	chain length determination region; other site
1036673007335	substrate-Mg2+ binding site; other site
1036673007336	catalytic residues [active]
1036673007337	aspartate-rich region 1; other site
1036673007338	active site lid residues [active]
1036673007339	aspartate-rich region 2; other site
1036673007340	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1036673007341	active site
1036673007342	multimer interface [polypeptide binding]; other site
1036673007343	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1036673007344	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1036673007345	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673007346	S-adenosylmethionine binding site [chemical binding]; other site
1036673007347	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1036673007348	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1036673007349	Tetramer interface [polypeptide binding]; other site
1036673007350	active site
1036673007351	FMN-binding site [chemical binding]; other site
1036673007352	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1036673007353	active site
1036673007354	dimer interface [polypeptide binding]; other site
1036673007355	metal binding site [ion binding]; metal-binding site
1036673007356	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
1036673007357	homotrimer interaction site [polypeptide binding]; other site
1036673007358	active site
1036673007359	anthranilate synthase component I; Provisional; Region: PRK13569
1036673007360	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1036673007361	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1036673007362	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1036673007363	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1036673007364	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1036673007365	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1036673007366	active site
1036673007367	ribulose/triose binding site [chemical binding]; other site
1036673007368	phosphate binding site [ion binding]; other site
1036673007369	substrate (anthranilate) binding pocket [chemical binding]; other site
1036673007370	product (indole) binding pocket [chemical binding]; other site
1036673007371	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1036673007372	active site
1036673007373	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1036673007374	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1036673007375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673007376	catalytic residue [active]
1036673007377	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1036673007378	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1036673007379	substrate binding site [chemical binding]; other site
1036673007380	active site
1036673007381	catalytic residues [active]
1036673007382	heterodimer interface [polypeptide binding]; other site
1036673007383	histidinol-phosphate aminotransferase; Provisional; Region: PRK03158
1036673007384	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673007385	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673007386	homodimer interface [polypeptide binding]; other site
1036673007387	catalytic residue [active]
1036673007388	prephenate dehydrogenase; Validated; Region: PRK06545
1036673007389	prephenate dehydrogenase; Validated; Region: PRK08507
1036673007390	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1036673007391	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1036673007392	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673007393	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673007394	DNA binding residues [nucleotide binding]
1036673007395	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
1036673007396	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1036673007397	catalytic core [active]
1036673007398	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1036673007399	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1036673007400	trimer interface [polypeptide binding]; other site
1036673007401	putative metal binding site [ion binding]; other site
1036673007402	IDEAL domain; Region: IDEAL; pfam08858
1036673007403	Protein of unknown function (DUF2487); Region: DUF2487; pfam10673
1036673007404	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1036673007405	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1036673007406	iron-sulfur cluster [ion binding]; other site
1036673007407	[2Fe-2S] cluster binding site [ion binding]; other site
1036673007408	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
1036673007409	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1036673007410	interchain domain interface [polypeptide binding]; other site
1036673007411	intrachain domain interface; other site
1036673007412	heme bH binding site [chemical binding]; other site
1036673007413	Qi binding site; other site
1036673007414	heme bL binding site [chemical binding]; other site
1036673007415	Qo binding site; other site
1036673007416	intrachain domain interface; other site
1036673007417	Qi binding site; other site
1036673007418	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
1036673007419	interchain domain interface [polypeptide binding]; other site
1036673007420	Qo binding site; other site
1036673007421	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1036673007422	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1036673007423	Protein of unknown function (DUF1405); Region: DUF1405; cl01798
1036673007424	Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800
1036673007425	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1036673007426	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1036673007427	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1036673007428	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1036673007429	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
1036673007430	homodimer interface [polypeptide binding]; other site
1036673007431	metal binding site [ion binding]; metal-binding site
1036673007432	TPR repeat; Region: TPR_11; pfam13414
1036673007433	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1036673007434	TPR motif; other site
1036673007435	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1036673007436	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1036673007437	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1036673007438	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1036673007439	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
1036673007440	active site
1036673007441	dimer interfaces [polypeptide binding]; other site
1036673007442	catalytic residues [active]
1036673007443	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
1036673007444	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
1036673007445	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
1036673007446	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1036673007447	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1036673007448	active site
1036673007449	NTP binding site [chemical binding]; other site
1036673007450	metal binding triad [ion binding]; metal-binding site
1036673007451	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1036673007452	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1036673007453	Biotin operon repressor [Transcription]; Region: BirA; COG1654
1036673007454	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1036673007455	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1036673007456	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1036673007457	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1036673007458	oligomerization interface [polypeptide binding]; other site
1036673007459	active site
1036673007460	metal binding site [ion binding]; metal-binding site
1036673007461	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1036673007462	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1036673007463	active site
1036673007464	ATP-binding site [chemical binding]; other site
1036673007465	pantoate-binding site; other site
1036673007466	HXXH motif; other site
1036673007467	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
1036673007468	tetramerization interface [polypeptide binding]; other site
1036673007469	active site
1036673007470	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1036673007471	binding surface
1036673007472	TPR repeat; Region: TPR_11; pfam13414
1036673007473	TPR motif; other site
1036673007474	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1036673007475	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
1036673007476	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1036673007477	active site
1036673007478	catalytic site [active]
1036673007479	substrate binding site [chemical binding]; other site
1036673007480	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673007481	ATP binding site [chemical binding]; other site
1036673007482	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1036673007483	putative Mg++ binding site [ion binding]; other site
1036673007484	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1036673007485	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1036673007486	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1036673007487	CoA binding domain; Region: CoA_binding; pfam02629
1036673007488	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1036673007489	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
1036673007490	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
1036673007491	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1036673007492	active site
1036673007493	putative substrate binding pocket [chemical binding]; other site
1036673007494	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
1036673007495	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1036673007496	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673007497	Walker A motif; other site
1036673007498	ATP binding site [chemical binding]; other site
1036673007499	Walker B motif; other site
1036673007500	arginine finger; other site
1036673007501	Peptidase family M41; Region: Peptidase_M41; pfam01434
1036673007502	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673007503	AMIN domain; Region: AMIN; pfam11741
1036673007504	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1036673007505	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1036673007506	active site
1036673007507	metal binding site [ion binding]; metal-binding site
1036673007508	Sporulation and spore germination; Region: Germane; cl11253
1036673007509	S-layer homology domain; Region: SLH; pfam00395
1036673007510	S-layer homology domain; Region: SLH; pfam00395
1036673007511	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1036673007512	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1036673007513	minor groove reading motif; other site
1036673007514	helix-hairpin-helix signature motif; other site
1036673007515	substrate binding pocket [chemical binding]; other site
1036673007516	active site
1036673007517	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1036673007518	Hydrogenase specific C-terminal endopeptidases, also called Hydrogen Maturation Proteases (H2MP). These enzymes belong to the peptidase family M52. Maturation of [FeNi] hydrogenases includes formation of the nickel metallocenter, proteolytic processing...; Region: H2MP; cl00477
1036673007519	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673007520	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673007521	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673007522	Walker A/P-loop; other site
1036673007523	ATP binding site [chemical binding]; other site
1036673007524	Q-loop/lid; other site
1036673007525	ABC transporter signature motif; other site
1036673007526	Walker B; other site
1036673007527	D-loop; other site
1036673007528	H-loop/switch region; other site
1036673007529	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673007530	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673007531	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1036673007532	Walker A/P-loop; other site
1036673007533	ATP binding site [chemical binding]; other site
1036673007534	Q-loop/lid; other site
1036673007535	ABC transporter signature motif; other site
1036673007536	Walker B; other site
1036673007537	D-loop; other site
1036673007538	H-loop/switch region; other site
1036673007539	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1036673007540	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673007541	G5 domain; Region: G5; pfam07501
1036673007542	Peptidase family M23; Region: Peptidase_M23; pfam01551
1036673007543	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1036673007544	active site
1036673007545	catalytic triad [active]
1036673007546	oxyanion hole [active]
1036673007547	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1036673007548	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1036673007549	Walker A/P-loop; other site
1036673007550	ATP binding site [chemical binding]; other site
1036673007551	Q-loop/lid; other site
1036673007552	ABC transporter signature motif; other site
1036673007553	Walker B; other site
1036673007554	D-loop; other site
1036673007555	H-loop/switch region; other site
1036673007556	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1036673007557	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1036673007558	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1036673007559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673007560	Mg2+ binding site [ion binding]; other site
1036673007561	G-X-G motif; other site
1036673007562	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1036673007563	anchoring element; other site
1036673007564	dimer interface [polypeptide binding]; other site
1036673007565	ATP binding site [chemical binding]; other site
1036673007566	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1036673007567	active site
1036673007568	metal binding site [ion binding]; metal-binding site
1036673007569	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1036673007570	DNA gyrase subunit A; Validated; Region: PRK05560
1036673007571	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1036673007572	CAP-like domain; other site
1036673007573	active site
1036673007574	primary dimer interface [polypeptide binding]; other site
1036673007575	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036673007576	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036673007577	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036673007578	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1036673007579	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673007580	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1036673007581	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1036673007582	active site
1036673007583	S-adenosylmethionine binding site [chemical binding]; other site
1036673007584	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1036673007585	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1036673007586	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1036673007587	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673007588	catalytic residue [active]
1036673007589	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673007590	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
1036673007591	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
1036673007592	glycogen branching enzyme; Provisional; Region: PRK12313
1036673007593	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1036673007594	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1036673007595	active site
1036673007596	catalytic site [active]
1036673007597	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1036673007598	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
1036673007599	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1036673007600	ligand binding site; other site
1036673007601	oligomer interface; other site
1036673007602	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1036673007603	dimer interface [polypeptide binding]; other site
1036673007604	N-terminal domain interface [polypeptide binding]; other site
1036673007605	sulfate 1 binding site; other site
1036673007606	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
1036673007607	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1036673007608	ligand binding site; other site
1036673007609	oligomer interface; other site
1036673007610	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1036673007611	dimer interface [polypeptide binding]; other site
1036673007612	N-terminal domain interface [polypeptide binding]; other site
1036673007613	sulfate 1 binding site; other site
1036673007614	glycogen synthase; Provisional; Region: glgA; PRK00654
1036673007615	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1036673007616	ADP-binding pocket [chemical binding]; other site
1036673007617	homodimer interface [polypeptide binding]; other site
1036673007618	GAF domain; Region: GAF; pfam01590
1036673007619	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1036673007620	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673007621	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673007622	dimer interface [polypeptide binding]; other site
1036673007623	phosphorylation site [posttranslational modification]
1036673007624	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673007625	ATP binding site [chemical binding]; other site
1036673007626	Mg2+ binding site [ion binding]; other site
1036673007627	G-X-G motif; other site
1036673007628	L,D-transpeptidase; Provisional; Region: PRK10260
1036673007629	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1036673007630	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1036673007631	Cache domain; Region: Cache_1; pfam02743
1036673007632	PAS domain S-box; Region: sensory_box; TIGR00229
1036673007633	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1036673007634	putative active site [active]
1036673007635	heme pocket [chemical binding]; other site
1036673007636	PAS domain S-box; Region: sensory_box; TIGR00229
1036673007637	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673007638	putative active site [active]
1036673007639	heme pocket [chemical binding]; other site
1036673007640	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673007641	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673007642	metal binding site [ion binding]; metal-binding site
1036673007643	active site
1036673007644	I-site; other site
1036673007645	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
1036673007646	Predicted nucleotide-binding protein containing TIR-like domain; Region: TIR-like; cl17861
1036673007647	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1036673007648	active site
1036673007649	Protein of unknown function (DUF2653); Region: DUF2653; pfam10850
1036673007650	Domain of unknown function (DUF309); Region: DUF309; pfam03745
1036673007651	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673007652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673007653	active site
1036673007654	phosphorylation site [posttranslational modification]
1036673007655	intermolecular recognition site; other site
1036673007656	dimerization interface [polypeptide binding]; other site
1036673007657	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673007658	DNA binding site [nucleotide binding]
1036673007659	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673007660	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673007661	dimerization interface [polypeptide binding]; other site
1036673007662	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673007663	dimer interface [polypeptide binding]; other site
1036673007664	phosphorylation site [posttranslational modification]
1036673007665	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673007666	ATP binding site [chemical binding]; other site
1036673007667	Mg2+ binding site [ion binding]; other site
1036673007668	G-X-G motif; other site
1036673007669	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1036673007670	active site clefts [active]
1036673007671	zinc binding site [ion binding]; other site
1036673007672	dimer interface [polypeptide binding]; other site
1036673007673	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
1036673007674	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
1036673007675	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
1036673007676	active site
1036673007677	Zn binding site [ion binding]; other site
1036673007678	Spore germination protein; Region: Spore_permease; cl17796
1036673007679	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673007680	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673007681	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673007682	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1036673007683	NMT1-like family; Region: NMT1_2; pfam13379
1036673007684	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1036673007685	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1036673007686	Walker A/P-loop; other site
1036673007687	ATP binding site [chemical binding]; other site
1036673007688	Q-loop/lid; other site
1036673007689	ABC transporter signature motif; other site
1036673007690	Walker B; other site
1036673007691	D-loop; other site
1036673007692	H-loop/switch region; other site
1036673007693	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036673007694	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673007695	dimer interface [polypeptide binding]; other site
1036673007696	conserved gate region; other site
1036673007697	putative PBP binding loops; other site
1036673007698	ABC-ATPase subunit interface; other site
1036673007699	Predicted membrane protein [Function unknown]; Region: COG4129
1036673007700	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1036673007701	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1036673007702	Outer spore coat protein E (CotE); Region: CotE; pfam10628
1036673007703	Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395
1036673007704	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1036673007705	MutS domain I; Region: MutS_I; pfam01624
1036673007706	MutS domain II; Region: MutS_II; pfam05188
1036673007707	MutS domain III; Region: MutS_III; pfam05192
1036673007708	MutS domain V; Region: MutS_V; pfam00488
1036673007709	Walker A/P-loop; other site
1036673007710	ATP binding site [chemical binding]; other site
1036673007711	Q-loop/lid; other site
1036673007712	ABC transporter signature motif; other site
1036673007713	Walker B; other site
1036673007714	D-loop; other site
1036673007715	H-loop/switch region; other site
1036673007716	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1036673007717	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1036673007718	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1036673007719	protein binding site [polypeptide binding]; other site
1036673007720	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1036673007721	Catalytic dyad [active]
1036673007722	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673007723	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1036673007724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673007725	ATP binding site [chemical binding]; other site
1036673007726	Mg2+ binding site [ion binding]; other site
1036673007727	G-X-G motif; other site
1036673007728	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1036673007729	ATP binding site [chemical binding]; other site
1036673007730	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1036673007731	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1036673007732	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673007733	S-adenosylmethionine binding site [chemical binding]; other site
1036673007734	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1036673007735	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1036673007736	bacterial Hfq-like; Region: Hfq; cd01716
1036673007737	hexamer interface [polypeptide binding]; other site
1036673007738	Sm1 motif; other site
1036673007739	RNA binding site [nucleotide binding]; other site
1036673007740	Sm2 motif; other site
1036673007741	Transglycosylase; Region: Transgly; pfam00912
1036673007742	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1036673007743	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1036673007744	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1036673007745	active site
1036673007746	Esterase/lipase [General function prediction only]; Region: COG1647
1036673007747	PGAP1-like protein; Region: PGAP1; pfam07819
1036673007748	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1036673007749	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673007750	active site
1036673007751	metal binding site [ion binding]; metal-binding site
1036673007752	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1036673007753	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1036673007754	putative active site [active]
1036673007755	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1036673007756	short chain dehydrogenase; Provisional; Region: PRK06701
1036673007757	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1036673007758	NAD binding site [chemical binding]; other site
1036673007759	metal binding site [ion binding]; metal-binding site
1036673007760	active site
1036673007761	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1036673007762	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673007763	motif II; other site
1036673007764	stage V sporulation protein K; Region: spore_V_K; TIGR02881
1036673007765	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673007766	Walker A motif; other site
1036673007767	ATP binding site [chemical binding]; other site
1036673007768	Walker B motif; other site
1036673007769	arginine finger; other site
1036673007770	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1036673007771	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1036673007772	HflX GTPase family; Region: HflX; cd01878
1036673007773	G1 box; other site
1036673007774	GTP/Mg2+ binding site [chemical binding]; other site
1036673007775	Switch I region; other site
1036673007776	G2 box; other site
1036673007777	G3 box; other site
1036673007778	Switch II region; other site
1036673007779	G4 box; other site
1036673007780	G5 box; other site
1036673007781	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
1036673007782	Aluminium resistance protein; Region: Alum_res; pfam06838
1036673007783	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1036673007784	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1036673007785	DNA binding residues [nucleotide binding]
1036673007786	putative dimer interface [polypeptide binding]; other site
1036673007787	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1036673007788	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1036673007789	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1036673007790	LexA repressor; Validated; Region: PRK00215
1036673007791	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673007792	putative DNA binding site [nucleotide binding]; other site
1036673007793	putative Zn2+ binding site [ion binding]; other site
1036673007794	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1036673007795	Catalytic site [active]
1036673007796	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673007797	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
1036673007798	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673007799	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673007800	active site
1036673007801	catalytic tetrad [active]
1036673007802	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1036673007803	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673007804	motif II; other site
1036673007805	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791
1036673007806	Cupin domain; Region: Cupin_2; cl17218
1036673007807	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
1036673007808	5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082
1036673007809	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
1036673007810	substrate binding pocket [chemical binding]; other site
1036673007811	dimer interface [polypeptide binding]; other site
1036673007812	inhibitor binding site; inhibition site
1036673007813	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
1036673007814	B12 binding site [chemical binding]; other site
1036673007815	cobalt ligand [ion binding]; other site
1036673007816	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
1036673007817	ribonuclease Z; Region: RNase_Z; TIGR02651
1036673007818	small acid-soluble spore protein Tlp; Provisional; Region: PRK03830
1036673007819	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1036673007820	Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346
1036673007821	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
1036673007822	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
1036673007823	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1036673007824	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1036673007825	putative acyl-acceptor binding pocket; other site
1036673007826	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1036673007827	phytoene desaturase; Region: crtI_fam; TIGR02734
1036673007828	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
1036673007829	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1036673007830	DXD motif; other site
1036673007831	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1036673007832	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
1036673007833	putative acyl-acceptor binding pocket; other site
1036673007834	Protein of unknown function (DUF422); Region: DUF422; cl00991
1036673007835	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
1036673007836	active site lid residues [active]
1036673007837	substrate binding pocket [chemical binding]; other site
1036673007838	catalytic residues [active]
1036673007839	substrate-Mg2+ binding site; other site
1036673007840	aspartate-rich region 1; other site
1036673007841	aspartate-rich region 2; other site
1036673007842	phytoene desaturase; Region: crtI_fam; TIGR02734
1036673007843	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036673007844	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1036673007845	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036673007846	phytoene desaturase; Region: crtI_fam; TIGR02734
1036673007847	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
1036673007848	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673007849	ATP binding site [chemical binding]; other site
1036673007850	putative Mg++ binding site [ion binding]; other site
1036673007851	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673007852	nucleotide binding region [chemical binding]; other site
1036673007853	ATP-binding site [chemical binding]; other site
1036673007854	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
1036673007855	RNase_H superfamily; Region: RNase_H_2; pfam13482
1036673007856	active site
1036673007857	substrate binding site [chemical binding]; other site
1036673007858	Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266
1036673007859	Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei  (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973
1036673007860	putative DNA binding site [nucleotide binding]; other site
1036673007861	catalytic residue [active]
1036673007862	putative H2TH interface [polypeptide binding]; other site
1036673007863	putative catalytic residues [active]
1036673007864	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1036673007865	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1036673007866	AP endonuclease family 2; Region: AP2Ec; smart00518
1036673007867	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
1036673007868	AP (apurinic/apyrimidinic) site pocket; other site
1036673007869	DNA interaction; other site
1036673007870	Metal-binding active site; metal-binding site
1036673007871	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1036673007872	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673007873	Walker A/P-loop; other site
1036673007874	ATP binding site [chemical binding]; other site
1036673007875	Q-loop/lid; other site
1036673007876	ABC transporter signature motif; other site
1036673007877	Walker B; other site
1036673007878	D-loop; other site
1036673007879	H-loop/switch region; other site
1036673007880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673007881	S-adenosylmethionine binding site [chemical binding]; other site
1036673007882	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036673007883	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673007884	S-adenosylmethionine binding site [chemical binding]; other site
1036673007885	AAA domain; Region: AAA_31; pfam13614
1036673007886	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1036673007887	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1036673007888	Walker A motif; other site
1036673007889	hexamer interface [polypeptide binding]; other site
1036673007890	ATP binding site [chemical binding]; other site
1036673007891	Walker B motif; other site
1036673007892	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1036673007893	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1036673007894	TadE-like protein; Region: TadE; pfam07811
1036673007895	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
1036673007896	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
1036673007897	phosphopeptide binding site; other site
1036673007898	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1036673007899	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
1036673007900	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1036673007901	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1036673007902	putative oligomer interface [polypeptide binding]; other site
1036673007903	putative active site [active]
1036673007904	metal binding site [ion binding]; metal-binding site
1036673007905	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1036673007906	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673007907	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673007908	ABC transporter; Region: ABC_tran_2; pfam12848
1036673007909	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673007910	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1036673007911	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673007912	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673007913	ABC transporter; Region: ABC_tran_2; pfam12848
1036673007914	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673007915	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1036673007916	catalytic residues [active]
1036673007917	Kinase associated protein B; Region: KapB; pfam08810
1036673007918	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673007919	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673007920	ATP binding site [chemical binding]; other site
1036673007921	Mg2+ binding site [ion binding]; other site
1036673007922	G-X-G motif; other site
1036673007923	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673007924	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673007925	active site
1036673007926	phosphorylation site [posttranslational modification]
1036673007927	intermolecular recognition site; other site
1036673007928	dimerization interface [polypeptide binding]; other site
1036673007929	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673007930	DNA binding residues [nucleotide binding]
1036673007931	dimerization interface [polypeptide binding]; other site
1036673007932	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673007933	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673007934	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673007935	Predicted membrane protein [Function unknown]; Region: COG2860
1036673007936	UPF0126 domain; Region: UPF0126; pfam03458
1036673007937	UPF0126 domain; Region: UPF0126; pfam03458
1036673007938	sporulation lipoprotein, YhcN/YlaJ family; Region: spore_YhcN_YlaJ; TIGR02898
1036673007939	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1036673007940	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673007941	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673007942	active site
1036673007943	phosphorylation site [posttranslational modification]
1036673007944	intermolecular recognition site; other site
1036673007945	dimerization interface [polypeptide binding]; other site
1036673007946	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673007947	DNA binding site [nucleotide binding]
1036673007948	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1036673007949	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673007950	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673007951	dimerization interface [polypeptide binding]; other site
1036673007952	putative DNA binding site [nucleotide binding]; other site
1036673007953	putative Zn2+ binding site [ion binding]; other site
1036673007954	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
1036673007955	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1036673007956	ATP-grasp domain; Region: ATP-grasp; pfam02222
1036673007957	Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987
1036673007958	Predicted membrane protein [Function unknown]; Region: COG4682
1036673007959	yiaA/B two helix domain; Region: YiaAB; pfam05360
1036673007960	yiaA/B two helix domain; Region: YiaAB; pfam05360
1036673007961	Predicted phosphoesterases, related to the Icc protein [General function prediction only]; Region: COG2129
1036673007962	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1036673007963	active site
1036673007964	metal binding site [ion binding]; metal-binding site
1036673007965	homotetramer interface [polypeptide binding]; other site
1036673007966	bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019
1036673007967	S-formylglutathione hydrolase; Region: PLN02442
1036673007968	Putative esterase; Region: Esterase; pfam00756
1036673007969	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1036673007970	Predicted ATPase [General function prediction only]; Region: COG3899
1036673007971	AAA ATPase domain; Region: AAA_16; pfam13191
1036673007972	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1036673007973	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
1036673007974	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673007975	TIGR01777 family protein; Region: yfcH
1036673007976	NAD(P) binding site [chemical binding]; other site
1036673007977	active site
1036673007978	DNA topoisomerase III; Provisional; Region: PRK07726
1036673007979	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1036673007980	active site
1036673007981	putative interdomain interaction site [polypeptide binding]; other site
1036673007982	putative metal-binding site [ion binding]; other site
1036673007983	putative nucleotide binding site [chemical binding]; other site
1036673007984	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1036673007985	domain I; other site
1036673007986	DNA binding groove [nucleotide binding]
1036673007987	phosphate binding site [ion binding]; other site
1036673007988	domain II; other site
1036673007989	domain III; other site
1036673007990	nucleotide binding site [chemical binding]; other site
1036673007991	catalytic site [active]
1036673007992	domain IV; other site
1036673007993	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1036673007994	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673007995	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673007996	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673007997	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673007998	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673007999	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673008000	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673008001	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673008002	active site
1036673008003	catalytic tetrad [active]
1036673008004	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
1036673008005	active site
1036673008006	Predicted transcriptional regulator [Transcription]; Region: COG2378
1036673008007	HTH domain; Region: HTH_11; pfam08279
1036673008008	WYL domain; Region: WYL; pfam13280
1036673008009	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276
1036673008010	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1036673008011	putative NAD(P) binding site [chemical binding]; other site
1036673008012	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673008013	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673008014	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673008015	dimerization interface [polypeptide binding]; other site
1036673008016	putative DNA binding site [nucleotide binding]; other site
1036673008017	putative Zn2+ binding site [ion binding]; other site
1036673008018	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1036673008019	hydrophobic ligand binding site; other site
1036673008020	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036673008021	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673008022	S-adenosylmethionine binding site [chemical binding]; other site
1036673008023	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1036673008024	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
1036673008025	putative active site [active]
1036673008026	catalytic triad [active]
1036673008027	putative dimer interface [polypeptide binding]; other site
1036673008028	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1036673008029	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1036673008030	E-class dimer interface [polypeptide binding]; other site
1036673008031	P-class dimer interface [polypeptide binding]; other site
1036673008032	active site
1036673008033	Cu2+ binding site [ion binding]; other site
1036673008034	Zn2+ binding site [ion binding]; other site
1036673008035	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673008036	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673008037	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673008038	dimerization interface [polypeptide binding]; other site
1036673008039	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1036673008040	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1036673008041	GDP-binding site [chemical binding]; other site
1036673008042	ACT binding site; other site
1036673008043	IMP binding site; other site
1036673008044	Protein of unknown function (DUF3900); Region: DUF3900; pfam13039
1036673008045	Domain of unknown function (DUF3898); Region: DUF3898; pfam13037
1036673008046	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2425
1036673008047	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1036673008048	metal ion-dependent adhesion site (MIDAS); other site
1036673008049	regulatory ATPase RavA; Provisional; Region: PRK13531
1036673008050	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673008051	Walker A motif; other site
1036673008052	ATP binding site [chemical binding]; other site
1036673008053	Walker B motif; other site
1036673008054	arginine finger; other site
1036673008055	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1036673008056	catalytic residues [active]
1036673008057	dimer interface [polypeptide binding]; other site
1036673008058	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
1036673008059	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
1036673008060	Ligand Binding Site [chemical binding]; other site
1036673008061	bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409
1036673008062	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1036673008063	dimerization interface [polypeptide binding]; other site
1036673008064	ligand binding site [chemical binding]; other site
1036673008065	NADP binding site [chemical binding]; other site
1036673008066	catalytic site [active]
1036673008067	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036673008068	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036673008069	Walker A/P-loop; other site
1036673008070	ATP binding site [chemical binding]; other site
1036673008071	Q-loop/lid; other site
1036673008072	ABC transporter signature motif; other site
1036673008073	Walker B; other site
1036673008074	D-loop; other site
1036673008075	H-loop/switch region; other site
1036673008076	FtsX-like permease family; Region: FtsX; pfam02687
1036673008077	peptide synthase; Provisional; Region: PRK12316
1036673008078	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673008079	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673008080	acyl-activating enzyme (AAE) consensus motif; other site
1036673008081	AMP binding site [chemical binding]; other site
1036673008082	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673008083	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673008084	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673008085	acyl-activating enzyme (AAE) consensus motif; other site
1036673008086	AMP binding site [chemical binding]; other site
1036673008087	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673008088	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673008089	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673008090	acyl-activating enzyme (AAE) consensus motif; other site
1036673008091	AMP binding site [chemical binding]; other site
1036673008092	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673008093	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673008094	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673008095	acyl-activating enzyme (AAE) consensus motif; other site
1036673008096	AMP binding site [chemical binding]; other site
1036673008097	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673008098	Condensation domain; Region: Condensation; pfam00668
1036673008099	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673008100	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673008101	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673008102	acyl-activating enzyme (AAE) consensus motif; other site
1036673008103	AMP binding site [chemical binding]; other site
1036673008104	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673008105	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673008106	Condensation domain; Region: Condensation; pfam00668
1036673008107	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673008108	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673008109	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673008110	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673008111	acyl-activating enzyme (AAE) consensus motif; other site
1036673008112	AMP binding site [chemical binding]; other site
1036673008113	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673008114	Condensation domain; Region: Condensation; pfam00668
1036673008115	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673008116	Condensation domain; Region: Condensation; pfam00668
1036673008117	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673008118	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673008119	acyl-activating enzyme (AAE) consensus motif; other site
1036673008120	AMP binding site [chemical binding]; other site
1036673008121	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673008122	Condensation domain; Region: Condensation; pfam00668
1036673008123	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673008124	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673008125	Condensation domain; Region: Condensation; pfam00668
1036673008126	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673008127	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673008128	acyl-activating enzyme (AAE) consensus motif; other site
1036673008129	AMP binding site [chemical binding]; other site
1036673008130	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673008131	Condensation domain; Region: Condensation; pfam00668
1036673008132	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673008133	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673008134	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673008135	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673008136	acyl-activating enzyme (AAE) consensus motif; other site
1036673008137	AMP binding site [chemical binding]; other site
1036673008138	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673008139	Condensation domain; Region: Condensation; pfam00668
1036673008140	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673008141	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673008142	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673008143	acyl-activating enzyme (AAE) consensus motif; other site
1036673008144	AMP binding site [chemical binding]; other site
1036673008145	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673008146	Condensation domain; Region: Condensation; pfam00668
1036673008147	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673008148	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673008149	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673008150	acyl-activating enzyme (AAE) consensus motif; other site
1036673008151	AMP binding site [chemical binding]; other site
1036673008152	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673008153	Condensation domain; Region: Condensation; pfam00668
1036673008154	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673008155	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673008156	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673008157	acyl-activating enzyme (AAE) consensus motif; other site
1036673008158	AMP binding site [chemical binding]; other site
1036673008159	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673008160	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1036673008161	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673008162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673008163	active site
1036673008164	phosphorylation site [posttranslational modification]
1036673008165	intermolecular recognition site; other site
1036673008166	dimerization interface [polypeptide binding]; other site
1036673008167	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673008168	DNA binding site [nucleotide binding]
1036673008169	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673008170	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673008171	ATP binding site [chemical binding]; other site
1036673008172	Mg2+ binding site [ion binding]; other site
1036673008173	G-X-G motif; other site
1036673008174	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673008175	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673008176	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1036673008177	Family description; Region: UvrD_C_2; pfam13538
1036673008178	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1036673008179	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673008180	non-specific DNA binding site [nucleotide binding]; other site
1036673008181	salt bridge; other site
1036673008182	sequence-specific DNA binding site [nucleotide binding]; other site
1036673008183	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1036673008184	Class II fumarases; Region: Fumarase_classII; cd01362
1036673008185	active site
1036673008186	tetramer interface [polypeptide binding]; other site
1036673008187	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
1036673008188	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1036673008189	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
1036673008190	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
1036673008191	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1036673008192	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1036673008193	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1036673008194	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1036673008195	ATP binding site [chemical binding]; other site
1036673008196	Walker A motif; other site
1036673008197	hexamer interface [polypeptide binding]; other site
1036673008198	Walker B motif; other site
1036673008199	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1036673008200	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1036673008201	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1036673008202	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673008203	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1036673008204	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673008205	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673008206	Peptidase family M23; Region: Peptidase_M23; pfam01551
1036673008207	H+ Antiporter protein; Region: 2A0121; TIGR00900
1036673008208	DNA topoisomerase III; Provisional; Region: PRK07726
1036673008209	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
1036673008210	active site
1036673008211	putative interdomain interaction site [polypeptide binding]; other site
1036673008212	putative metal-binding site [ion binding]; other site
1036673008213	putative nucleotide binding site [chemical binding]; other site
1036673008214	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1036673008215	domain I; other site
1036673008216	DNA binding groove [nucleotide binding]
1036673008217	phosphate binding site [ion binding]; other site
1036673008218	domain II; other site
1036673008219	domain III; other site
1036673008220	nucleotide binding site [chemical binding]; other site
1036673008221	catalytic site [active]
1036673008222	domain IV; other site
1036673008223	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1036673008224	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1036673008225	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1036673008226	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673008227	dimer interface [polypeptide binding]; other site
1036673008228	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1036673008229	putative CheW interface [polypeptide binding]; other site
1036673008230	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1036673008231	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1036673008232	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1036673008233	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1036673008234	metal binding site 2 [ion binding]; metal-binding site
1036673008235	putative DNA binding helix; other site
1036673008236	metal binding site 1 [ion binding]; metal-binding site
1036673008237	dimer interface [polypeptide binding]; other site
1036673008238	structural Zn2+ binding site [ion binding]; other site
1036673008239	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673008240	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1036673008241	substrate binding pocket [chemical binding]; other site
1036673008242	membrane-bound complex binding site; other site
1036673008243	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1036673008244	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673008245	dimer interface [polypeptide binding]; other site
1036673008246	conserved gate region; other site
1036673008247	putative PBP binding loops; other site
1036673008248	ABC-ATPase subunit interface; other site
1036673008249	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673008250	dimer interface [polypeptide binding]; other site
1036673008251	conserved gate region; other site
1036673008252	putative PBP binding loops; other site
1036673008253	ABC-ATPase subunit interface; other site
1036673008254	ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296
1036673008255	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1036673008256	Walker A/P-loop; other site
1036673008257	ATP binding site [chemical binding]; other site
1036673008258	Q-loop/lid; other site
1036673008259	ABC transporter signature motif; other site
1036673008260	Walker B; other site
1036673008261	D-loop; other site
1036673008262	H-loop/switch region; other site
1036673008263	TOBE domain; Region: TOBE_2; pfam08402
1036673008264	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1036673008265	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1036673008266	Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055
1036673008267	FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567
1036673008268	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1036673008269	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1036673008270	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673008271	substrate binding pocket [chemical binding]; other site
1036673008272	membrane-bound complex binding site; other site
1036673008273	hinge residues; other site
1036673008274	alkanesulfonate monooxygenase; Provisional; Region: PRK00719
1036673008275	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1036673008276	dimer interface [polypeptide binding]; other site
1036673008277	active site
1036673008278	non-prolyl cis peptide bond; other site
1036673008279	insertion regions; other site
1036673008280	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036673008281	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673008282	dimer interface [polypeptide binding]; other site
1036673008283	conserved gate region; other site
1036673008284	putative PBP binding loops; other site
1036673008285	ABC-ATPase subunit interface; other site
1036673008286	aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247
1036673008287	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1036673008288	Walker A/P-loop; other site
1036673008289	ATP binding site [chemical binding]; other site
1036673008290	Q-loop/lid; other site
1036673008291	ABC transporter signature motif; other site
1036673008292	Walker B; other site
1036673008293	D-loop; other site
1036673008294	H-loop/switch region; other site
1036673008295	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1036673008296	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1036673008297	Walker A/P-loop; other site
1036673008298	ATP binding site [chemical binding]; other site
1036673008299	Q-loop/lid; other site
1036673008300	ABC transporter signature motif; other site
1036673008301	Walker B; other site
1036673008302	D-loop; other site
1036673008303	H-loop/switch region; other site
1036673008304	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036673008305	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673008306	dimer interface [polypeptide binding]; other site
1036673008307	conserved gate region; other site
1036673008308	putative PBP binding loops; other site
1036673008309	ABC-ATPase subunit interface; other site
1036673008310	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1036673008311	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673008312	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673008313	active site
1036673008314	catalytic tetrad [active]
1036673008315	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673008316	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673008317	putative substrate translocation pore; other site
1036673008318	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1036673008319	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673008320	substrate binding pocket [chemical binding]; other site
1036673008321	membrane-bound complex binding site; other site
1036673008322	hinge residues; other site
1036673008323	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1036673008324	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673008325	dimer interface [polypeptide binding]; other site
1036673008326	conserved gate region; other site
1036673008327	ABC-ATPase subunit interface; other site
1036673008328	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1036673008329	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1036673008330	Walker A/P-loop; other site
1036673008331	ATP binding site [chemical binding]; other site
1036673008332	Q-loop/lid; other site
1036673008333	ABC transporter signature motif; other site
1036673008334	Walker B; other site
1036673008335	D-loop; other site
1036673008336	H-loop/switch region; other site
1036673008337	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1036673008338	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1036673008339	M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672
1036673008340	metal binding site [ion binding]; metal-binding site
1036673008341	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
1036673008342	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1036673008343	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673008344	Walker A/P-loop; other site
1036673008345	ATP binding site [chemical binding]; other site
1036673008346	Q-loop/lid; other site
1036673008347	ABC transporter signature motif; other site
1036673008348	Walker B; other site
1036673008349	D-loop; other site
1036673008350	H-loop/switch region; other site
1036673008351	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1036673008352	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1036673008353	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036673008354	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268
1036673008355	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1036673008356	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1036673008357	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1036673008358	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1036673008359	AAA domain; Region: AAA_18; pfam13238
1036673008360	ATP-binding site [chemical binding]; other site
1036673008361	Sugar specificity; other site
1036673008362	Pyrimidine base specificity; other site
1036673008363	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1036673008364	classical (c) SDRs; Region: SDR_c; cd05233
1036673008365	NAD(P) binding site [chemical binding]; other site
1036673008366	active site
1036673008367	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1036673008368	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1036673008369	Ca binding site [ion binding]; other site
1036673008370	active site
1036673008371	catalytic site [active]
1036673008372	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1036673008373	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1036673008374	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1036673008375	dimer interface [polypeptide binding]; other site
1036673008376	active site
1036673008377	metal binding site [ion binding]; metal-binding site
1036673008378	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673008379	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673008380	putative substrate translocation pore; other site
1036673008381	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
1036673008382	nucleotide binding site/active site [active]
1036673008383	HIT family signature motif; other site
1036673008384	catalytic residue [active]
1036673008385	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673008386	Coenzyme A binding pocket [chemical binding]; other site
1036673008387	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1036673008388	tetracycline repressor protein TetR; Provisional; Region: PRK13756
1036673008389	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673008390	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
1036673008391	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1036673008392	lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175
1036673008393	active site
1036673008394	active site
1036673008395	catalytic residues [active]
1036673008396	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
1036673008397	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1036673008398	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1036673008399	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673008400	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673008401	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
1036673008402	D-mannose binding lectin; Region: B_lectin; pfam01453
1036673008403	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1036673008404	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673008405	DNA-binding site [nucleotide binding]; DNA binding site
1036673008406	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1036673008407	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673008408	D-galactonate transporter; Region: 2A0114; TIGR00893
1036673008409	putative substrate translocation pore; other site
1036673008410	transketolase; Reviewed; Region: PRK05899
1036673008411	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1036673008412	TPP-binding site [chemical binding]; other site
1036673008413	dimer interface [polypeptide binding]; other site
1036673008414	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1036673008415	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1036673008416	PYR/PP interface [polypeptide binding]; other site
1036673008417	dimer interface [polypeptide binding]; other site
1036673008418	TPP binding site [chemical binding]; other site
1036673008419	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1036673008420	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1036673008421	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673008422	NAD(P) binding site [chemical binding]; other site
1036673008423	active site
1036673008424	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1036673008425	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1036673008426	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673008427	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673008428	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673008429	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1036673008430	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1036673008431	Walker A/P-loop; other site
1036673008432	ATP binding site [chemical binding]; other site
1036673008433	Q-loop/lid; other site
1036673008434	ABC transporter signature motif; other site
1036673008435	Walker B; other site
1036673008436	D-loop; other site
1036673008437	H-loop/switch region; other site
1036673008438	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673008439	ABC-ATPase subunit  interface; other site
1036673008440	dimer interface [polypeptide binding]; other site
1036673008441	putative PBP binding regions; other site
1036673008442	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1036673008443	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673008444	ABC-ATPase subunit  interface; other site
1036673008445	dimer interface [polypeptide binding]; other site
1036673008446	putative PBP binding regions; other site
1036673008447	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1036673008448	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1036673008449	siderophore binding site; other site
1036673008450	Predicted membrane protein [Function unknown]; Region: COG2364
1036673008451	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1036673008452	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673008453	Coenzyme A binding pocket [chemical binding]; other site
1036673008454	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673008455	MarR family; Region: MarR; pfam01047
1036673008456	DoxX-like family; Region: DoxX_2; pfam13564
1036673008457	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673008458	dimerization interface [polypeptide binding]; other site
1036673008459	putative DNA binding site [nucleotide binding]; other site
1036673008460	putative Zn2+ binding site [ion binding]; other site
1036673008461	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1036673008462	putative hydrophobic ligand binding site [chemical binding]; other site
1036673008463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1036673008464	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1036673008465	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1036673008466	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
1036673008467	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1036673008468	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1036673008469	DNA binding residues [nucleotide binding]
1036673008470	putative dimer interface [polypeptide binding]; other site
1036673008471	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
1036673008472	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1036673008473	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673008474	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673008475	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1036673008476	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1036673008477	putative NAD(P) binding site [chemical binding]; other site
1036673008478	putative substrate binding site [chemical binding]; other site
1036673008479	catalytic Zn binding site [ion binding]; other site
1036673008480	structural Zn binding site [ion binding]; other site
1036673008481	dimer interface [polypeptide binding]; other site
1036673008482	Uncharacterized conserved protein [Function unknown]; Region: COG4925
1036673008483	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar1; cd08583
1036673008484	putative active site [active]
1036673008485	catalytic site [active]
1036673008486	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1036673008487	Domain of unknown function (DUF4317); Region: DUF4317; pfam14199
1036673008488	Helix-turn-helix domain; Region: HTH_17; pfam12728
1036673008489	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673008490	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673008491	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673008492	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1036673008493	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673008494	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1036673008495	Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876
1036673008496	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673008497	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673008498	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673008499	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1036673008500	classical (c) SDRs; Region: SDR_c; cd05233
1036673008501	NAD(P) binding site [chemical binding]; other site
1036673008502	active site
1036673008503	galactonate dehydratase; Provisional; Region: PRK14017
1036673008504	D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325
1036673008505	putative active site pocket [active]
1036673008506	putative metal binding site [ion binding]; other site
1036673008507	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
1036673008508	Predicted transcriptional regulators [Transcription]; Region: COG1695
1036673008509	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1036673008510	CAAX protease self-immunity; Region: Abi; pfam02517
1036673008511	serine/threonine transporter SstT; Provisional; Region: PRK13628
1036673008512	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1036673008513	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1036673008514	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1036673008515	dimer interface [polypeptide binding]; other site
1036673008516	FMN binding site [chemical binding]; other site
1036673008517	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673008518	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673008519	putative DNA binding site [nucleotide binding]; other site
1036673008520	putative Zn2+ binding site [ion binding]; other site
1036673008521	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1036673008522	catalytic core [active]
1036673008523	Phosphotransferase enzyme family; Region: APH; pfam01636
1036673008524	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1036673008525	active site
1036673008526	substrate binding site [chemical binding]; other site
1036673008527	ATP binding site [chemical binding]; other site
1036673008528	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
1036673008529	DinB superfamily; Region: DinB_2; pfam12867
1036673008530	Domain of unknown function (DUF4272); Region: DUF4272; pfam14094
1036673008531	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
1036673008532	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048
1036673008533	RNAase interaction site [polypeptide binding]; other site
1036673008534	Helix-turn-helix domain; Region: HTH_17; pfam12728
1036673008535	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1036673008536	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1036673008537	putative oxidoreductase; Provisional; Region: PRK08275
1036673008538	L-aspartate oxidase; Provisional; Region: PRK06175
1036673008539	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1036673008540	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1036673008541	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1036673008542	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1036673008543	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673008544	membrane-bound complex binding site; other site
1036673008545	hinge residues; other site
1036673008546	Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475
1036673008547	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036673008548	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673008549	dimer interface [polypeptide binding]; other site
1036673008550	conserved gate region; other site
1036673008551	putative PBP binding loops; other site
1036673008552	ABC-ATPase subunit interface; other site
1036673008553	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1036673008554	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1036673008555	Walker A/P-loop; other site
1036673008556	ATP binding site [chemical binding]; other site
1036673008557	Q-loop/lid; other site
1036673008558	ABC transporter signature motif; other site
1036673008559	Walker B; other site
1036673008560	D-loop; other site
1036673008561	H-loop/switch region; other site
1036673008562	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673008563	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1036673008564	active site
1036673008565	metal binding site [ion binding]; metal-binding site
1036673008566	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
1036673008567	dimer interface [polypeptide binding]; other site
1036673008568	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673008569	ligand binding site [chemical binding]; other site
1036673008570	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673008571	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673008572	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
1036673008573	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1036673008574	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1036673008575	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673008576	S-adenosylmethionine binding site [chemical binding]; other site
1036673008577	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1036673008578	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673008579	Coenzyme A binding pocket [chemical binding]; other site
1036673008580	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673008581	S-adenosylmethionine binding site [chemical binding]; other site
1036673008582	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673008583	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673008584	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673008585	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673008586	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673008587	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1036673008588	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1036673008589	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1036673008590	active site
1036673008591	PAS fold; Region: PAS_4; pfam08448
1036673008592	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673008593	putative active site [active]
1036673008594	heme pocket [chemical binding]; other site
1036673008595	PAS domain S-box; Region: sensory_box; TIGR00229
1036673008596	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673008597	putative active site [active]
1036673008598	heme pocket [chemical binding]; other site
1036673008599	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1036673008600	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673008601	putative active site [active]
1036673008602	heme pocket [chemical binding]; other site
1036673008603	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673008604	dimer interface [polypeptide binding]; other site
1036673008605	phosphorylation site [posttranslational modification]
1036673008606	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673008607	ATP binding site [chemical binding]; other site
1036673008608	Mg2+ binding site [ion binding]; other site
1036673008609	G-X-G motif; other site
1036673008610	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673008611	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673008612	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673008613	S-adenosylmethionine binding site [chemical binding]; other site
1036673008614	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673008615	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673008616	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673008617	KIAA1161 is an uncharacterized Homo sapiens protein with a glycosyl hydrolase family 31 (GH31) domain that is homologous to the Escherichia coli YihQ glucosidase. Orthologs of KIA1161 are found in eukaryotes and prokaryotes. In bacteria, YihQ (along with...; Region: GH31_glucosidase_KIAA1161; cd06592
1036673008618	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
1036673008619	putative active site [active]
1036673008620	putative catalytic site [active]
1036673008621	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1036673008622	Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482
1036673008623	active site
1036673008624	catalytic triad [active]
1036673008625	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1036673008626	catalytic residues [active]
1036673008627	Protein of unknown function (DUF419); Region: DUF419; cl15265
1036673008628	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1036673008629	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
1036673008630	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
1036673008631	putative active site [active]
1036673008632	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1036673008633	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
1036673008634	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
1036673008635	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1036673008636	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1036673008637	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
1036673008638	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1036673008639	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1036673008640	metal-binding site
1036673008641	xanthine dehydrogenase C subunit; Region: pucC; TIGR03199
1036673008642	xanthine dehydrogenase D subunit; Region: pucD; TIGR03196
1036673008643	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1036673008644	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1036673008645	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1036673008646	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111
1036673008647	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1036673008648	NMT1/THI5 like; Region: NMT1; pfam09084
1036673008649	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673008650	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673008651	active site
1036673008652	phosphorylation site [posttranslational modification]
1036673008653	intermolecular recognition site; other site
1036673008654	dimerization interface [polypeptide binding]; other site
1036673008655	Creatinine amidohydrolase; Region: Creatininase; pfam02633
1036673008656	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1036673008657	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1036673008658	Walker A/P-loop; other site
1036673008659	ATP binding site [chemical binding]; other site
1036673008660	Q-loop/lid; other site
1036673008661	ABC transporter signature motif; other site
1036673008662	Walker B; other site
1036673008663	D-loop; other site
1036673008664	H-loop/switch region; other site
1036673008665	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1036673008666	FAD binding domain; Region: FAD_binding_4; pfam01565
1036673008667	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036673008668	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673008669	dimer interface [polypeptide binding]; other site
1036673008670	conserved gate region; other site
1036673008671	ABC-ATPase subunit interface; other site
1036673008672	cytosine deaminase; Provisional; Region: PRK09230
1036673008673	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1036673008674	active site
1036673008675	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1036673008676	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1036673008677	NMT1/THI5 like; Region: NMT1; pfam09084
1036673008678	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673008679	substrate binding pocket [chemical binding]; other site
1036673008680	hinge residues; other site
1036673008681	cytosine deaminase; Provisional; Region: PRK09230
1036673008682	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1036673008683	active site
1036673008684	OHCU decarboxylase; Region: OHCU_decarbox; cl01251
1036673008685	Uricase (urate oxidase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3648
1036673008686	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
1036673008687	active site
1036673008688	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1036673008689	active site
1036673008690	homotetramer interface [polypeptide binding]; other site
1036673008691	allantoinase; Provisional; Region: PRK06189
1036673008692	L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315
1036673008693	active site
1036673008694	allantoate amidohydrolase; Reviewed; Region: PRK09290
1036673008695	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1036673008696	active site
1036673008697	metal binding site [ion binding]; metal-binding site
1036673008698	dimer interface [polypeptide binding]; other site
1036673008699	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
1036673008700	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036673008701	catalytic residue [active]
1036673008702	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1036673008703	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1036673008704	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1036673008705	Predicted transcriptional regulators [Transcription]; Region: COG1695
1036673008706	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1036673008707	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
1036673008708	NPCBM/NEW2 domain; Region: NPCBM; cl07060
1036673008709	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
1036673008710	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
1036673008711	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144
1036673008712	4Fe-4S binding domain; Region: Fer4; cl02805
1036673008713	4Fe-4S binding domain; Region: Fer4; pfam00037
1036673008714	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
1036673008715	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1036673008716	dimer interface [polypeptide binding]; other site
1036673008717	PYR/PP interface [polypeptide binding]; other site
1036673008718	TPP binding site [chemical binding]; other site
1036673008719	substrate binding site [chemical binding]; other site
1036673008720	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
1036673008721	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1036673008722	TPP-binding site [chemical binding]; other site
1036673008723	DoxX-like family; Region: DoxX_2; pfam13564
1036673008724	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673008725	Coenzyme A binding pocket [chemical binding]; other site
1036673008726	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1036673008727	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673008728	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1036673008729	Coenzyme A binding pocket [chemical binding]; other site
1036673008730	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673008731	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673008732	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673008733	short chain dehydrogenase; Provisional; Region: PRK06180
1036673008734	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1036673008735	NADP binding site [chemical binding]; other site
1036673008736	active site
1036673008737	steroid binding site; other site
1036673008738	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673008739	MarR family; Region: MarR_2; pfam12802
1036673008740	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1036673008741	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1036673008742	EamA-like transporter family; Region: EamA; pfam00892
1036673008743	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1036673008744	GAF domain; Region: GAF_2; pfam13185
1036673008745	EDD domain protein, DegV family; Region: DegV; TIGR00762
1036673008746	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1036673008747	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1036673008748	EamA-like transporter family; Region: EamA; pfam00892
1036673008749	EamA-like transporter family; Region: EamA; pfam00892
1036673008750	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
1036673008751	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1036673008752	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673008753	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673008754	active site
1036673008755	phosphorylation site [posttranslational modification]
1036673008756	intermolecular recognition site; other site
1036673008757	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673008758	DNA binding site [nucleotide binding]
1036673008759	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673008760	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673008761	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
1036673008762	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1036673008763	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1036673008764	putative active site [active]
1036673008765	short chain dehydrogenase; Provisional; Region: PRK06924
1036673008766	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673008767	NAD(P) binding site [chemical binding]; other site
1036673008768	active site
1036673008769	benzoate transport; Region: 2A0115; TIGR00895
1036673008770	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673008771	putative substrate translocation pore; other site
1036673008772	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1036673008773	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1036673008774	NADP binding site [chemical binding]; other site
1036673008775	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1036673008776	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1036673008777	catalytic residues [active]
1036673008778	FlaG protein; Region: FlaG; pfam03646
1036673008779	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1036673008780	alanine racemase; Reviewed; Region: alr; PRK00053
1036673008781	active site
1036673008782	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1036673008783	dimer interface [polypeptide binding]; other site
1036673008784	substrate binding site [chemical binding]; other site
1036673008785	catalytic residues [active]
1036673008786	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1036673008787	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1036673008788	hexamer interface [polypeptide binding]; other site
1036673008789	ligand binding site [chemical binding]; other site
1036673008790	putative active site [active]
1036673008791	NAD(P) binding site [chemical binding]; other site
1036673008792	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1036673008793	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1036673008794	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1036673008795	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673008796	S-adenosylmethionine binding site [chemical binding]; other site
1036673008797	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1036673008798	Protein of unknown function (DUF2533); Region: DUF2533; pfam10752
1036673008799	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_33; cd04692
1036673008800	nudix motif; other site
1036673008801	Protein of unknown function (DUF445); Region: DUF445; pfam04286
1036673008802	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
1036673008803	active site
1036673008804	catalytic residues [active]
1036673008805	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
1036673008806	dimer interface [polypeptide binding]; other site
1036673008807	FMN binding site [chemical binding]; other site
1036673008808	Domain of unknown function (DUF1904); Region: DUF1904; pfam08921
1036673008809	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1036673008810	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673008811	Coenzyme A binding pocket [chemical binding]; other site
1036673008812	beta-D-glucuronidase; Provisional; Region: PRK10150
1036673008813	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1036673008814	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673008815	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1036673008816	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673008817	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673008818	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673008819	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1036673008820	putative active site [active]
1036673008821	putative metal binding site [ion binding]; other site
1036673008822	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
1036673008823	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1036673008824	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673008825	non-specific DNA binding site [nucleotide binding]; other site
1036673008826	salt bridge; other site
1036673008827	sequence-specific DNA binding site [nucleotide binding]; other site
1036673008828	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
1036673008829	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673008830	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1036673008831	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
1036673008832	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1036673008833	Substrate binding site; other site
1036673008834	Cupin domain; Region: Cupin_2; cl17218
1036673008835	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1036673008836	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1036673008837	NADP-binding site; other site
1036673008838	homotetramer interface [polypeptide binding]; other site
1036673008839	substrate binding site [chemical binding]; other site
1036673008840	homodimer interface [polypeptide binding]; other site
1036673008841	active site
1036673008842	This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809
1036673008843	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673008844	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
1036673008845	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1036673008846	inhibitor-cofactor binding pocket; inhibition site
1036673008847	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673008848	catalytic residue [active]
1036673008849	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
1036673008850	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
1036673008851	putative trimer interface [polypeptide binding]; other site
1036673008852	putative CoA binding site [chemical binding]; other site
1036673008853	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673008854	Domain of unknown function (DUF4386); Region: DUF4386; pfam14329
1036673008855	iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411
1036673008856	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1036673008857	siderophore binding site; other site
1036673008858	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1036673008859	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673008860	ABC-ATPase subunit  interface; other site
1036673008861	dimer interface [polypeptide binding]; other site
1036673008862	putative PBP binding regions; other site
1036673008863	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673008864	ABC-ATPase subunit  interface; other site
1036673008865	dimer interface [polypeptide binding]; other site
1036673008866	putative PBP binding regions; other site
1036673008867	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
1036673008868	substrate binding site [chemical binding]; other site
1036673008869	active site
1036673008870	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1036673008871	dimer interface [polypeptide binding]; other site
1036673008872	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673008873	Cupin domain; Region: Cupin_2; pfam07883
1036673008874	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673008875	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673008876	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
1036673008877	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
1036673008878	metal binding site [ion binding]; metal-binding site
1036673008879	ligand binding site [chemical binding]; other site
1036673008880	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1036673008881	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
1036673008882	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1036673008883	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1036673008884	protein binding site [polypeptide binding]; other site
1036673008885	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673008886	MarR family; Region: MarR; pfam01047
1036673008887	Epoxide hydrolase N terminus; Region: EHN; pfam06441
1036673008888	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673008889	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1036673008890	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1036673008891	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1036673008892	Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457
1036673008893	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
1036673008894	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1036673008895	generic binding surface I; other site
1036673008896	generic binding surface II; other site
1036673008897	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036673008898	Zn2+ binding site [ion binding]; other site
1036673008899	Mg2+ binding site [ion binding]; other site
1036673008900	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1036673008901	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
1036673008902	beta-galactosidase; Region: BGL; TIGR03356
1036673008903	hypothetical protein; Provisional; Region: PRK12378
1036673008904	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673008905	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1036673008906	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673008907	Coenzyme A binding pocket [chemical binding]; other site
1036673008908	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036673008909	Zn2+ binding site [ion binding]; other site
1036673008910	Mg2+ binding site [ion binding]; other site
1036673008911	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036673008912	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673008913	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673008914	Spore coat protein (Spore_GerQ); Region: Spore_GerQ; cl09881
1036673008915	preprotein translocase subunit SecA; Reviewed; Region: PRK12326
1036673008916	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1036673008917	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673008918	nucleotide binding region [chemical binding]; other site
1036673008919	ATP-binding site [chemical binding]; other site
1036673008920	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1036673008921	dimer interface [polypeptide binding]; other site
1036673008922	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673008923	RNA polymerase factor sigma-70; Validated; Region: PRK08241
1036673008924	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673008925	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673008926	DNA binding residues [nucleotide binding]
1036673008927	SnoaL-like domain; Region: SnoaL_2; pfam12680
1036673008928	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_4; cd08897
1036673008929	putative hydrophobic ligand binding site [chemical binding]; other site
1036673008930	DoxX-like family; Region: DoxX_2; pfam13564
1036673008931	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1036673008932	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1036673008933	FMN binding site [chemical binding]; other site
1036673008934	active site
1036673008935	substrate binding site [chemical binding]; other site
1036673008936	catalytic residue [active]
1036673008937	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673008938	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673008939	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1036673008940	Uncharacterized protein conserved in bacteria (DUF2262); Region: DUF2262; pfam10020
1036673008941	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673008942	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673008943	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1036673008944	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1036673008945	NADP binding site [chemical binding]; other site
1036673008946	RibD C-terminal domain; Region: RibD_C; cl17279
1036673008947	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1036673008948	AAA domain; Region: AAA_33; pfam13671
1036673008949	Immunity protein Imm6; Region: Imm6; pfam14434
1036673008950	S-layer homology domain; Region: SLH; pfam00395
1036673008951	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036673008952	MULE transposase domain; Region: MULE; pfam10551
1036673008953	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673008954	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673008955	active site
1036673008956	catalytic tetrad [active]
1036673008957	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1036673008958	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1036673008959	DNA binding residues [nucleotide binding]
1036673008960	putative dimer interface [polypeptide binding]; other site
1036673008961	DinB family; Region: DinB; cl17821
1036673008962	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673008963	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673008964	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1036673008965	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1036673008966	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673008967	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673008968	active site
1036673008969	catalytic tetrad [active]
1036673008970	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1036673008971	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1036673008972	DNA binding residues [nucleotide binding]
1036673008973	putative dimer interface [polypeptide binding]; other site
1036673008974	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1036673008975	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673008976	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673008977	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673008978	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673008979	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673008980	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673008981	dimerization interface [polypeptide binding]; other site
1036673008982	putative DNA binding site [nucleotide binding]; other site
1036673008983	putative Zn2+ binding site [ion binding]; other site
1036673008984	arsenical pump membrane protein; Provisional; Region: PRK15445
1036673008985	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
1036673008986	transmembrane helices; other site
1036673008987	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1036673008988	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1036673008989	active site
1036673008990	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
1036673008991	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673008992	putative metal binding site [ion binding]; other site
1036673008993	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
1036673008994	active site
1036673008995	catalytic residues [active]
1036673008996	putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018
1036673008997	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1036673008998	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_20; cd07254
1036673008999	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673009000	putative metal binding site [ion binding]; other site
1036673009001	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1036673009002	FtsX-like permease family; Region: FtsX; pfam02687
1036673009003	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036673009004	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036673009005	Walker A/P-loop; other site
1036673009006	ATP binding site [chemical binding]; other site
1036673009007	Q-loop/lid; other site
1036673009008	ABC transporter signature motif; other site
1036673009009	Walker B; other site
1036673009010	D-loop; other site
1036673009011	H-loop/switch region; other site
1036673009012	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673009013	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673009014	dimer interface [polypeptide binding]; other site
1036673009015	phosphorylation site [posttranslational modification]
1036673009016	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673009017	ATP binding site [chemical binding]; other site
1036673009018	Mg2+ binding site [ion binding]; other site
1036673009019	G-X-G motif; other site
1036673009020	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673009021	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673009022	active site
1036673009023	phosphorylation site [posttranslational modification]
1036673009024	intermolecular recognition site; other site
1036673009025	dimerization interface [polypeptide binding]; other site
1036673009026	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673009027	DNA binding site [nucleotide binding]
1036673009028	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673009029	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673009030	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673009031	Transposase domain (DUF772); Region: DUF772; pfam05598
1036673009032	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1036673009033	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1036673009034	RNA polymerase sigma factor SigY; Reviewed; Region: PRK09638
1036673009035	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673009036	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673009037	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673009038	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673009039	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673009040	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1036673009041	active site
1036673009042	metal binding site [ion binding]; metal-binding site
1036673009043	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
1036673009044	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1036673009045	DNA binding residues [nucleotide binding]
1036673009046	drug binding residues [chemical binding]; other site
1036673009047	dimer interface [polypeptide binding]; other site
1036673009048	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1036673009049	short chain dehydrogenase; Provisional; Region: PRK12747
1036673009050	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1036673009051	NADP binding site [chemical binding]; other site
1036673009052	homodimer interface [polypeptide binding]; other site
1036673009053	active site
1036673009054	substrate binding site [chemical binding]; other site
1036673009055	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1036673009056	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1036673009057	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1036673009058	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1036673009059	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1036673009060	putative substrate binding site [chemical binding]; other site
1036673009061	putative ATP binding site [chemical binding]; other site
1036673009062	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
1036673009063	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1036673009064	active site
1036673009065	P-loop; other site
1036673009066	phosphorylation site [posttranslational modification]
1036673009067	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1036673009068	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1036673009069	active site
1036673009070	phosphorylation site [posttranslational modification]
1036673009071	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
1036673009072	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1036673009073	active site
1036673009074	catalytic triad [active]
1036673009075	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
1036673009076	Bacillus subtilis aldehyde dehydrogenase ywdH-like; Region: ALDH_YwdH-P39616; cd07136
1036673009077	NAD(P) binding site [chemical binding]; other site
1036673009078	catalytic residues [active]
1036673009079	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1036673009080	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673009081	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673009082	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1036673009083	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1036673009084	ligand binding site [chemical binding]; other site
1036673009085	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673009086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673009087	active site
1036673009088	phosphorylation site [posttranslational modification]
1036673009089	intermolecular recognition site; other site
1036673009090	dimerization interface [polypeptide binding]; other site
1036673009091	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673009092	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673009093	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673009094	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673009095	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673009096	dimerization interface [polypeptide binding]; other site
1036673009097	Histidine kinase; Region: His_kinase; pfam06580
1036673009098	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673009099	ATP binding site [chemical binding]; other site
1036673009100	Mg2+ binding site [ion binding]; other site
1036673009101	G-X-G motif; other site
1036673009102	Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309
1036673009103	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1036673009104	putative ligand binding site [chemical binding]; other site
1036673009105	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1036673009106	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1036673009107	Walker A/P-loop; other site
1036673009108	ATP binding site [chemical binding]; other site
1036673009109	Q-loop/lid; other site
1036673009110	ABC transporter signature motif; other site
1036673009111	Walker B; other site
1036673009112	D-loop; other site
1036673009113	H-loop/switch region; other site
1036673009114	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1036673009115	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673009116	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1036673009117	TM-ABC transporter signature motif; other site
1036673009118	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673009119	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1036673009120	TM-ABC transporter signature motif; other site
1036673009121	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
1036673009122	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673009123	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673009124	Domain of unknown function (DUF1961); Region: DUF1961; pfam09224
1036673009125	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673009126	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673009127	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673009128	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673009129	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673009130	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673009131	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673009132	Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399
1036673009133	putative active site [active]
1036673009134	putative metal binding site [ion binding]; other site
1036673009135	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673009136	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_10; cd08865
1036673009137	putative hydrophobic ligand binding site [chemical binding]; other site
1036673009138	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar1; cd08583
1036673009139	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1036673009140	putative active site [active]
1036673009141	catalytic site [active]
1036673009142	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673009143	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1036673009144	active site
1036673009145	metal binding site [ion binding]; metal-binding site
1036673009146	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1036673009147	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1036673009148	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673009149	dimer interface [polypeptide binding]; other site
1036673009150	conserved gate region; other site
1036673009151	ABC-ATPase subunit interface; other site
1036673009152	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
1036673009153	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1036673009154	Walker A/P-loop; other site
1036673009155	ATP binding site [chemical binding]; other site
1036673009156	Q-loop/lid; other site
1036673009157	ABC transporter signature motif; other site
1036673009158	Walker B; other site
1036673009159	D-loop; other site
1036673009160	H-loop/switch region; other site
1036673009161	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1036673009162	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1036673009163	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1036673009164	substrate binding site [chemical binding]; other site
1036673009165	dimer interface [polypeptide binding]; other site
1036673009166	ATP binding site [chemical binding]; other site
1036673009167	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
1036673009168	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673009169	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673009170	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1036673009171	Cytochrome P450; Region: p450; pfam00067
1036673009172	Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369
1036673009173	Flavodoxin; Region: Flavodoxin_1; pfam00258
1036673009174	These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206
1036673009175	FAD binding pocket [chemical binding]; other site
1036673009176	FAD binding motif [chemical binding]; other site
1036673009177	catalytic residues [active]
1036673009178	NAD binding pocket [chemical binding]; other site
1036673009179	phosphate binding motif [ion binding]; other site
1036673009180	beta-alpha-beta structure motif; other site
1036673009181	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673009182	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673009183	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673009184	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673009185	active site
1036673009186	catalytic tetrad [active]
1036673009187	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673009188	putative substrate translocation pore; other site
1036673009189	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673009190	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1036673009191	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1036673009192	Catalytic site [active]
1036673009193	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1036673009194	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1036673009195	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1036673009196	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1036673009197	metal binding site [ion binding]; metal-binding site
1036673009198	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
1036673009199	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
1036673009200	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1036673009201	metal binding site [ion binding]; metal-binding site
1036673009202	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1036673009203	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1036673009204	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1036673009205	metal binding site [ion binding]; metal-binding site
1036673009206	Fn3 associated; Region: Fn3_assoc; pfam13287
1036673009207	Fn3 associated; Region: Fn3_assoc; pfam13287
1036673009208	S-layer homology domain; Region: SLH; pfam00395
1036673009209	S-layer homology domain; Region: SLH; pfam00395
1036673009210	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1036673009211	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673009212	non-specific DNA binding site [nucleotide binding]; other site
1036673009213	salt bridge; other site
1036673009214	sequence-specific DNA binding site [nucleotide binding]; other site
1036673009215	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1036673009216	SpoVR like protein; Region: SpoVR; pfam04293
1036673009217	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
1036673009218	asparagine synthetase AsnA; Provisional; Region: PRK05425
1036673009219	motif 1; other site
1036673009220	dimer interface [polypeptide binding]; other site
1036673009221	active site
1036673009222	motif 2; other site
1036673009223	motif 3; other site
1036673009224	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1036673009225	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673009226	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673009227	dimer interface [polypeptide binding]; other site
1036673009228	phosphorylation site [posttranslational modification]
1036673009229	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673009230	ATP binding site [chemical binding]; other site
1036673009231	Mg2+ binding site [ion binding]; other site
1036673009232	G-X-G motif; other site
1036673009233	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673009234	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673009235	active site
1036673009236	phosphorylation site [posttranslational modification]
1036673009237	intermolecular recognition site; other site
1036673009238	dimerization interface [polypeptide binding]; other site
1036673009239	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673009240	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673009241	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673009242	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673009243	dimerization interface [polypeptide binding]; other site
1036673009244	Histidine kinase; Region: His_kinase; pfam06580
1036673009245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673009246	ATP binding site [chemical binding]; other site
1036673009247	Mg2+ binding site [ion binding]; other site
1036673009248	G-X-G motif; other site
1036673009249	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673009250	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673009251	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673009252	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673009253	dimer interface [polypeptide binding]; other site
1036673009254	conserved gate region; other site
1036673009255	ABC-ATPase subunit interface; other site
1036673009256	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673009257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673009258	dimer interface [polypeptide binding]; other site
1036673009259	conserved gate region; other site
1036673009260	ABC-ATPase subunit interface; other site
1036673009261	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
1036673009262	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1036673009263	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1036673009264	active site
1036673009265	catalytic residues [active]
1036673009266	reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719
1036673009267	ethanolamine ammonia lyase large subunit; Provisional; Region: PRK15067
1036673009268	Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751
1036673009269	Ethanolamine ammonia-lyase light chain (EutC); Region: EutC; pfam05985
1036673009270	ethanolamine permease; Region: 2A0305; TIGR00908
1036673009271	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673009272	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
1036673009273	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
1036673009274	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1036673009275	active site
1036673009276	putative pectinesterase; Region: PLN02432; cl01911
1036673009277	Pectinesterase; Region: Pectinesterase; pfam01095
1036673009278	threonine synthase; Validated; Region: PRK08197
1036673009279	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1036673009280	homodimer interface [polypeptide binding]; other site
1036673009281	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673009282	catalytic residue [active]
1036673009283	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673009284	dimer interface [polypeptide binding]; other site
1036673009285	conserved gate region; other site
1036673009286	putative PBP binding loops; other site
1036673009287	ABC-ATPase subunit interface; other site
1036673009288	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1036673009289	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673009290	dimer interface [polypeptide binding]; other site
1036673009291	conserved gate region; other site
1036673009292	putative PBP binding loops; other site
1036673009293	ABC-ATPase subunit interface; other site
1036673009294	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1036673009295	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1036673009296	Walker A/P-loop; other site
1036673009297	ATP binding site [chemical binding]; other site
1036673009298	Q-loop/lid; other site
1036673009299	ABC transporter signature motif; other site
1036673009300	Walker B; other site
1036673009301	D-loop; other site
1036673009302	H-loop/switch region; other site
1036673009303	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1036673009304	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673009305	substrate binding pocket [chemical binding]; other site
1036673009306	membrane-bound complex binding site; other site
1036673009307	hinge residues; other site
1036673009308	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
1036673009309	FAD binding site [chemical binding]; other site
1036673009310	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1036673009311	putative active site [active]
1036673009312	putative metal binding site [ion binding]; other site
1036673009313	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
1036673009314	active site
1036673009315	catalytic triad [active]
1036673009316	oxyanion hole [active]
1036673009317	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
1036673009318	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1036673009319	NodB motif; other site
1036673009320	active site
1036673009321	catalytic site [active]
1036673009322	metal binding site [ion binding]; metal-binding site
1036673009323	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1036673009324	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1036673009325	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1036673009326	putative active site [active]
1036673009327	HTH domain; Region: HTH_11; pfam08279
1036673009328	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1036673009329	FOG: CBS domain [General function prediction only]; Region: COG0517
1036673009330	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
1036673009331	Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033
1036673009332	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1036673009333	Moco binding site; other site
1036673009334	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1036673009335	metal coordination site [ion binding]; other site
1036673009336	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1036673009337	MOSC domain; Region: MOSC; pfam03473
1036673009338	3-alpha domain; Region: 3-alpha; pfam03475
1036673009339	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1036673009340	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1036673009341	GTP binding site; other site
1036673009342	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
1036673009343	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673009344	FeS/SAM binding site; other site
1036673009345	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1036673009346	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1036673009347	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1036673009348	dimer interface [polypeptide binding]; other site
1036673009349	putative functional site; other site
1036673009350	putative MPT binding site; other site
1036673009351	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1036673009352	Src Homology 3 domain superfamily; Region: SH3; cd00174
1036673009353	Bacterial SH3 domain; Region: SH3_3; pfam08239
1036673009354	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1036673009355	NlpC/P60 family; Region: NLPC_P60; cl17555
1036673009356	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673009357	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673009358	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1036673009359	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673009360	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673009361	DNA binding residues [nucleotide binding]
1036673009362	putative anti-sigmaE protein; Provisional; Region: PRK13920
1036673009363	Putative zinc-finger; Region: zf-HC2; pfam13490
1036673009364	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
1036673009365	Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552
1036673009366	carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851
1036673009367	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673009368	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673009369	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673009370	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1036673009371	active site
1036673009372	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673009373	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1036673009374	active site
1036673009375	metal binding site [ion binding]; metal-binding site
1036673009376	phage shock protein A; Region: phageshock_pspA; TIGR02977
1036673009377	PspC domain; Region: PspC; pfam04024
1036673009378	PspA/IM30 family; Region: PspA_IM30; pfam04012
1036673009379	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1036673009380	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1036673009381	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673009382	dimerization interface [polypeptide binding]; other site
1036673009383	Histidine kinase; Region: HisKA_3; pfam07730
1036673009384	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673009385	ATP binding site [chemical binding]; other site
1036673009386	Mg2+ binding site [ion binding]; other site
1036673009387	G-X-G motif; other site
1036673009388	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673009389	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673009390	active site
1036673009391	phosphorylation site [posttranslational modification]
1036673009392	intermolecular recognition site; other site
1036673009393	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673009394	DNA binding residues [nucleotide binding]
1036673009395	dimerization interface [polypeptide binding]; other site
1036673009396	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673009397	Coenzyme A binding pocket [chemical binding]; other site
1036673009398	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1036673009399	Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231
1036673009400	sugar binding site [chemical binding]; other site
1036673009401	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
1036673009402	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
1036673009403	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
1036673009404	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673009405	Interdomain contacts; other site
1036673009406	S-layer homology domain; Region: SLH; pfam00395
1036673009407	S-layer homology domain; Region: SLH; pfam00395
1036673009408	S-layer homology domain; Region: SLH; pfam00395
1036673009409	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1036673009410	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1036673009411	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1036673009412	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1036673009413	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673009414	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1036673009415	active site
1036673009416	metal binding site [ion binding]; metal-binding site
1036673009417	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1036673009418	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1036673009419	G1 box; other site
1036673009420	putative GEF interaction site [polypeptide binding]; other site
1036673009421	GTP/Mg2+ binding site [chemical binding]; other site
1036673009422	Switch I region; other site
1036673009423	G2 box; other site
1036673009424	G3 box; other site
1036673009425	Switch II region; other site
1036673009426	G4 box; other site
1036673009427	G5 box; other site
1036673009428	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1036673009429	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673009430	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1036673009431	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1036673009432	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402
1036673009433	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
1036673009434	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673009435	dimerization interface [polypeptide binding]; other site
1036673009436	ligand binding site [chemical binding]; other site
1036673009437	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673009438	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673009439	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673009440	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1036673009441	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673009442	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673009443	Small, acid-soluble spore protein I; Region: SSPI; cl07940
1036673009444	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1036673009445	TrkA-N domain; Region: TrkA_N; pfam02254
1036673009446	TrkA-C domain; Region: TrkA_C; pfam02080
1036673009447	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1036673009448	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1036673009449	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1036673009450	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1036673009451	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1036673009452	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673009453	MarR family; Region: MarR_2; pfam12802
1036673009454	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673009455	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673009456	active site
1036673009457	phosphorylation site [posttranslational modification]
1036673009458	intermolecular recognition site; other site
1036673009459	dimerization interface [polypeptide binding]; other site
1036673009460	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673009461	DNA binding site [nucleotide binding]
1036673009462	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673009463	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673009464	dimerization interface [polypeptide binding]; other site
1036673009465	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673009466	dimer interface [polypeptide binding]; other site
1036673009467	phosphorylation site [posttranslational modification]
1036673009468	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673009469	ATP binding site [chemical binding]; other site
1036673009470	Mg2+ binding site [ion binding]; other site
1036673009471	G-X-G motif; other site
1036673009472	VPS10 domain; Region: VPS10; smart00602
1036673009473	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1036673009474	Putative cell wall binding repeat 2; Region: CW_binding_2; pfam04122
1036673009475	Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026
1036673009476	putative transporter; Provisional; Region: PRK10054
1036673009477	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673009478	putative substrate translocation pore; other site
1036673009479	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1036673009480	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1036673009481	putative active site [active]
1036673009482	catalytic site [active]
1036673009483	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1036673009484	putative active site [active]
1036673009485	catalytic site [active]
1036673009486	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1036673009487	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1036673009488	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1036673009489	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1036673009490	Walker A/P-loop; other site
1036673009491	ATP binding site [chemical binding]; other site
1036673009492	Q-loop/lid; other site
1036673009493	ABC transporter signature motif; other site
1036673009494	Walker B; other site
1036673009495	D-loop; other site
1036673009496	H-loop/switch region; other site
1036673009497	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
1036673009498	cobalt transport protein CbiN; Provisional; Region: PRK02898
1036673009499	cobalt transport protein CbiM; Validated; Region: PRK08319
1036673009500	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
1036673009501	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_19; cd08518
1036673009502	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1036673009503	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1036673009504	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673009505	dimer interface [polypeptide binding]; other site
1036673009506	conserved gate region; other site
1036673009507	putative PBP binding loops; other site
1036673009508	ABC-ATPase subunit interface; other site
1036673009509	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1036673009510	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1036673009511	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673009512	Walker A/P-loop; other site
1036673009513	ATP binding site [chemical binding]; other site
1036673009514	Q-loop/lid; other site
1036673009515	ABC transporter signature motif; other site
1036673009516	Walker B; other site
1036673009517	D-loop; other site
1036673009518	H-loop/switch region; other site
1036673009519	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1036673009520	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673009521	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1036673009522	Walker A/P-loop; other site
1036673009523	ATP binding site [chemical binding]; other site
1036673009524	Q-loop/lid; other site
1036673009525	ABC transporter signature motif; other site
1036673009526	Walker B; other site
1036673009527	D-loop; other site
1036673009528	H-loop/switch region; other site
1036673009529	Predicted membrane protein [Function unknown]; Region: COG1511
1036673009530	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1036673009531	Predicted membrane protein [Function unknown]; Region: COG1511
1036673009532	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1036673009533	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
1036673009534	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673009535	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673009536	DNA binding site [nucleotide binding]
1036673009537	domain linker motif; other site
1036673009538	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
1036673009539	dimerization interface [polypeptide binding]; other site
1036673009540	ligand binding site [chemical binding]; other site
1036673009541	sodium binding site [ion binding]; other site
1036673009542	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673009543	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673009544	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673009545	dimer interface [polypeptide binding]; other site
1036673009546	conserved gate region; other site
1036673009547	putative PBP binding loops; other site
1036673009548	ABC-ATPase subunit interface; other site
1036673009549	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673009550	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673009551	dimer interface [polypeptide binding]; other site
1036673009552	conserved gate region; other site
1036673009553	putative PBP binding loops; other site
1036673009554	ABC-ATPase subunit interface; other site
1036673009555	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1036673009556	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1036673009557	substrate binding [chemical binding]; other site
1036673009558	active site
1036673009559	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1036673009560	azoreductase; Reviewed; Region: PRK00170
1036673009561	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1036673009562	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673009563	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673009564	active site
1036673009565	catalytic tetrad [active]
1036673009566	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1036673009567	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
1036673009568	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1036673009569	catalytic residues [active]
1036673009570	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673009571	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673009572	DNA binding residues [nucleotide binding]
1036673009573	dimerization interface [polypeptide binding]; other site
1036673009574	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
1036673009575	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1036673009576	PYR/PP interface [polypeptide binding]; other site
1036673009577	dimer interface [polypeptide binding]; other site
1036673009578	TPP binding site [chemical binding]; other site
1036673009579	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1036673009580	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1036673009581	TPP-binding site [chemical binding]; other site
1036673009582	dimer interface [polypeptide binding]; other site
1036673009583	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1036673009584	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1036673009585	putative valine binding site [chemical binding]; other site
1036673009586	dimer interface [polypeptide binding]; other site
1036673009587	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1036673009588	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673009589	dimerization interface [polypeptide binding]; other site
1036673009590	putative DNA binding site [nucleotide binding]; other site
1036673009591	putative Zn2+ binding site [ion binding]; other site
1036673009592	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673009593	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673009594	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673009595	dimerization interface [polypeptide binding]; other site
1036673009596	DinB superfamily; Region: DinB_2; pfam12867
1036673009597	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
1036673009598	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1036673009599	Peptidase family M23; Region: Peptidase_M23; pfam01551
1036673009600	Protein of unknown function DUF111; Region: DUF111; cl03398
1036673009601	hypothetical protein; Provisional; Region: PRK04194
1036673009602	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
1036673009603	AIR carboxylase; Region: AIRC; smart01001
1036673009604	lipoyl synthase; Provisional; Region: PRK05481
1036673009605	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673009606	FeS/SAM binding site; other site
1036673009607	NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255
1036673009608	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1036673009609	PilZ domain; Region: PilZ; pfam07238
1036673009610	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
1036673009611	putative homodimer interface [polypeptide binding]; other site
1036673009612	putative active site pocket [active]
1036673009613	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
1036673009614	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
1036673009615	Nucleoside recognition; Region: Gate; pfam07670
1036673009616	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1036673009617	apolar tunnel; other site
1036673009618	heme binding site [chemical binding]; other site
1036673009619	dimerization interface [polypeptide binding]; other site
1036673009620	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
1036673009621	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
1036673009622	YycC-like protein; Region: YycC; pfam14174
1036673009623	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
1036673009624	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607
1036673009625	active site
1036673009626	Zn binding site [ion binding]; other site
1036673009627	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
1036673009628	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673009629	dimer interface [polypeptide binding]; other site
1036673009630	putative metal binding site [ion binding]; other site
1036673009631	General stress protein [General function prediction only]; Region: GsiB; COG3729
1036673009632	General stress protein [General function prediction only]; Region: GsiB; COG3729
1036673009633	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1036673009634	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1036673009635	putative active site [active]
1036673009636	putative metal binding site [ion binding]; other site
1036673009637	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
1036673009638	active site
1036673009639	catalytic residues [active]
1036673009640	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
1036673009641	TIGR03943 family protein; Region: TIGR03943
1036673009642	Predicted permease; Region: DUF318; cl17795
1036673009643	Predicted permease; Region: DUF318; cl17795
1036673009644	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1036673009645	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1036673009646	active site
1036673009647	HIGH motif; other site
1036673009648	dimer interface [polypeptide binding]; other site
1036673009649	KMSKS motif; other site
1036673009650	Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988
1036673009651	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673009652	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673009653	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673009654	Walker A/P-loop; other site
1036673009655	ATP binding site [chemical binding]; other site
1036673009656	Q-loop/lid; other site
1036673009657	ABC transporter signature motif; other site
1036673009658	Walker B; other site
1036673009659	D-loop; other site
1036673009660	H-loop/switch region; other site
1036673009661	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673009662	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673009663	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1036673009664	Walker A/P-loop; other site
1036673009665	ATP binding site [chemical binding]; other site
1036673009666	Q-loop/lid; other site
1036673009667	ABC transporter signature motif; other site
1036673009668	Walker B; other site
1036673009669	D-loop; other site
1036673009670	H-loop/switch region; other site
1036673009671	Cupin domain; Region: Cupin_2; pfam07883
1036673009672	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673009673	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673009674	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1036673009675	beta-galactosidase; Region: BGL; TIGR03356
1036673009676	MFS/sugar transport protein; Region: MFS_2; pfam13347
1036673009677	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673009678	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1036673009679	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1036673009680	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1036673009681	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
1036673009682	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673009683	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1036673009684	E-class dimer interface [polypeptide binding]; other site
1036673009685	P-class dimer interface [polypeptide binding]; other site
1036673009686	active site
1036673009687	Cu2+ binding site [ion binding]; other site
1036673009688	Zn2+ binding site [ion binding]; other site
1036673009689	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673009690	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673009691	active site
1036673009692	catalytic tetrad [active]
1036673009693	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1036673009694	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
1036673009695	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1036673009696	FOG: HEAT repeat [Energy production and conversion]; Region: COG1413
1036673009697	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1036673009698	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1036673009699	DHHA2 domain; Region: DHHA2; pfam02833
1036673009700	Amb_all domain; Region: Amb_all; smart00656
1036673009701	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1036673009702	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1036673009703	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
1036673009704	NAD binding site [chemical binding]; other site
1036673009705	dimer interface [polypeptide binding]; other site
1036673009706	substrate binding site [chemical binding]; other site
1036673009707	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1036673009708	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1036673009709	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1036673009710	DinB superfamily; Region: DinB_2; pfam12867
1036673009711	Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671
1036673009712	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1036673009713	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673009714	NAD(P) binding site [chemical binding]; other site
1036673009715	active site
1036673009716	short chain dehydrogenase; Provisional; Region: PRK06914
1036673009717	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1036673009718	NADP binding site [chemical binding]; other site
1036673009719	active site
1036673009720	steroid binding site; other site
1036673009721	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673009722	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673009723	active site
1036673009724	catalytic tetrad [active]
1036673009725	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1036673009726	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1036673009727	Walker A/P-loop; other site
1036673009728	ATP binding site [chemical binding]; other site
1036673009729	Q-loop/lid; other site
1036673009730	ABC transporter signature motif; other site
1036673009731	Walker B; other site
1036673009732	D-loop; other site
1036673009733	H-loop/switch region; other site
1036673009734	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1036673009735	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1036673009736	Walker A/P-loop; other site
1036673009737	ATP binding site [chemical binding]; other site
1036673009738	Q-loop/lid; other site
1036673009739	ABC transporter signature motif; other site
1036673009740	Walker B; other site
1036673009741	D-loop; other site
1036673009742	H-loop/switch region; other site
1036673009743	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1036673009744	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1036673009745	TM-ABC transporter signature motif; other site
1036673009746	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1036673009747	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673009748	TM-ABC transporter signature motif; other site
1036673009749	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1036673009750	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1036673009751	putative ligand binding site [chemical binding]; other site
1036673009752	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1036673009753	alpha-gamma subunit interface [polypeptide binding]; other site
1036673009754	beta-gamma subunit interface [polypeptide binding]; other site
1036673009755	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1036673009756	gamma-beta subunit interface [polypeptide binding]; other site
1036673009757	alpha-beta subunit interface [polypeptide binding]; other site
1036673009758	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1036673009759	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1036673009760	subunit interactions [polypeptide binding]; other site
1036673009761	active site
1036673009762	flap region; other site
1036673009763	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1036673009764	UreF; Region: UreF; pfam01730
1036673009765	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673009766	Walker A motif; other site
1036673009767	ATP binding site [chemical binding]; other site
1036673009768	arginine finger; other site
1036673009769	UreD urease accessory protein; Region: UreD; cl00530
1036673009770	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1036673009771	UbiA prenyltransferase family; Region: UbiA; pfam01040
1036673009772	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1036673009773	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1036673009774	Cu(I) binding site [ion binding]; other site
1036673009775	Predicted permeases [General function prediction only]; Region: COG0679
1036673009776	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1036673009777	active site
1036673009778	metal binding site [ion binding]; metal-binding site
1036673009779	S-layer homology domain; Region: SLH; pfam00395
1036673009780	S-layer homology domain; Region: SLH; pfam00395
1036673009781	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673009782	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673009783	putative substrate translocation pore; other site
1036673009784	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1036673009785	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1036673009786	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1036673009787	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673009788	motif II; other site
1036673009789	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1036673009790	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1036673009791	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1036673009792	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1036673009793	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1036673009794	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1036673009795	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1036673009796	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1036673009797	intersubunit interface [polypeptide binding]; other site
1036673009798	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1036673009799	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1036673009800	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1036673009801	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673009802	dimer interface [polypeptide binding]; other site
1036673009803	ABC-ATPase subunit  interface; other site
1036673009804	putative PBP binding regions; other site
1036673009805	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1036673009806	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673009807	ABC-ATPase subunit  interface; other site
1036673009808	dimer interface [polypeptide binding]; other site
1036673009809	putative PBP binding regions; other site
1036673009810	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1036673009811	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
1036673009812	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1036673009813	active site
1036673009814	dimer interface [polypeptide binding]; other site
1036673009815	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1036673009816	Ligand Binding Site [chemical binding]; other site
1036673009817	Molecular Tunnel; other site
1036673009818	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1036673009819	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673009820	Protein of unknown function (DUF456); Region: DUF456; pfam04306
1036673009821	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1036673009822	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1036673009823	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1036673009824	Protein of unknown function (DUF2515); Region: DUF2515; pfam10720
1036673009825	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673009826	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
1036673009827	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1036673009828	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
1036673009829	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1036673009830	catalytic residues [active]
1036673009831	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
1036673009832	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1036673009833	EamA-like transporter family; Region: EamA; pfam00892
1036673009834	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1036673009835	EamA-like transporter family; Region: EamA; pfam00892
1036673009836	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
1036673009837	classical (c) SDRs; Region: SDR_c; cd05233
1036673009838	NAD(P) binding site [chemical binding]; other site
1036673009839	active site
1036673009840	NifU-like domain; Region: NifU; cl00484
1036673009841	hypothetical protein; Provisional; Region: PRK13669
1036673009842	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1036673009843	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036673009844	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
1036673009845	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673009846	FeS/SAM binding site; other site
1036673009847	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1036673009848	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1036673009849	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1036673009850	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036673009851	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036673009852	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1036673009853	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036673009854	Predicted glycosyl hydrolase [General function prediction only]; Region: COG3858
1036673009855	Cortical fragment-lytic enzyme (CFLE) is a peptidoglycan hydrolase involved in  bacterial endospore germination.  CFLE is expressed as an inactive preprotein (called SleB) in the forespore compartment of sporulating cells.  SleB translocates across the...; Region: GH18_CFLE_spore_hydrolase; cd02874
1036673009856	active site
1036673009857	putative heme peroxidase; Provisional; Region: PRK12276
1036673009858	Putative membrane protein; Region: YuiB; pfam14068
1036673009859	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1036673009860	primosomal protein DnaI; Reviewed; Region: PRK08939
1036673009861	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673009862	Walker A motif; other site
1036673009863	ATP binding site [chemical binding]; other site
1036673009864	Walker B motif; other site
1036673009865	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1036673009866	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1036673009867	catalytic residues [active]
1036673009868	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1036673009869	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1036673009870	GIY-YIG motif/motif A; other site
1036673009871	active site
1036673009872	catalytic site [active]
1036673009873	putative DNA binding site [nucleotide binding]; other site
1036673009874	metal binding site [ion binding]; metal-binding site
1036673009875	UvrB/uvrC motif; Region: UVR; pfam02151
1036673009876	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1036673009877	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
1036673009878	DNA binding site [nucleotide binding]
1036673009879	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1036673009880	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1036673009881	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1036673009882	TrkA-N domain; Region: TrkA_N; pfam02254
1036673009883	TrkA-C domain; Region: TrkA_C; pfam02080
1036673009884	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
1036673009885	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1036673009886	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673009887	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673009888	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673009889	dimerization interface [polypeptide binding]; other site
1036673009890	Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497
1036673009891	proximal heme binding site [chemical binding]; other site
1036673009892	distal heme binding site [chemical binding]; other site
1036673009893	putative dimer interface [polypeptide binding]; other site
1036673009894	putative Iron-sulfur protein interface [polypeptide binding]; other site
1036673009895	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641
1036673009896	L-aspartate oxidase; Provisional; Region: PRK06175
1036673009897	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1036673009898	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640
1036673009899	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1036673009900	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673009901	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673009902	DNA binding site [nucleotide binding]
1036673009903	domain linker motif; other site
1036673009904	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673009905	ligand binding site [chemical binding]; other site
1036673009906	dimerization interface [polypeptide binding]; other site
1036673009907	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1036673009908	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1036673009909	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1036673009910	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1036673009911	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1036673009912	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1036673009913	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1036673009914	Histidine kinase; Region: HisKA_3; pfam07730
1036673009915	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673009916	ATP binding site [chemical binding]; other site
1036673009917	Mg2+ binding site [ion binding]; other site
1036673009918	G-X-G motif; other site
1036673009919	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673009920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673009921	active site
1036673009922	phosphorylation site [posttranslational modification]
1036673009923	intermolecular recognition site; other site
1036673009924	dimerization interface [polypeptide binding]; other site
1036673009925	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673009926	DNA binding residues [nucleotide binding]
1036673009927	dimerization interface [polypeptide binding]; other site
1036673009928	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1036673009929	Putative sensor; Region: Sensor; pfam13796
1036673009930	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1036673009931	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1036673009932	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673009933	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673009934	active site
1036673009935	phosphorylation site [posttranslational modification]
1036673009936	intermolecular recognition site; other site
1036673009937	dimerization interface [polypeptide binding]; other site
1036673009938	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673009939	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673009940	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673009941	dimerization interface [polypeptide binding]; other site
1036673009942	Histidine kinase; Region: His_kinase; pfam06580
1036673009943	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673009944	ATP binding site [chemical binding]; other site
1036673009945	Mg2+ binding site [ion binding]; other site
1036673009946	G-X-G motif; other site
1036673009947	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673009948	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673009949	dimer interface [polypeptide binding]; other site
1036673009950	conserved gate region; other site
1036673009951	ABC-ATPase subunit interface; other site
1036673009952	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673009953	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673009954	dimer interface [polypeptide binding]; other site
1036673009955	conserved gate region; other site
1036673009956	putative PBP binding loops; other site
1036673009957	ABC-ATPase subunit interface; other site
1036673009958	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1036673009959	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673009960	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673009961	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673009962	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1036673009963	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673009964	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673009965	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673009966	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673009967	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1036673009968	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673009969	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673009970	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673009971	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673009972	dimer interface [polypeptide binding]; other site
1036673009973	conserved gate region; other site
1036673009974	ABC-ATPase subunit interface; other site
1036673009975	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673009976	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673009977	dimer interface [polypeptide binding]; other site
1036673009978	conserved gate region; other site
1036673009979	putative PBP binding loops; other site
1036673009980	ABC-ATPase subunit interface; other site
1036673009981	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673009982	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
1036673009983	Pectate lyase; Region: Pec_lyase_C; cl01593
1036673009984	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1036673009985	synthetase active site [active]
1036673009986	NTP binding site [chemical binding]; other site
1036673009987	metal binding site [ion binding]; metal-binding site
1036673009988	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1036673009989	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673009990	sequence-specific DNA binding site [nucleotide binding]; other site
1036673009991	salt bridge; other site
1036673009992	Cupin domain; Region: Cupin_2; pfam07883
1036673009993	LysE type translocator; Region: LysE; cl00565
1036673009994	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1036673009995	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1036673009996	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1036673009997	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1036673009998	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673009999	putative substrate translocation pore; other site
1036673010000	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673010001	putative DNA binding site [nucleotide binding]; other site
1036673010002	dimerization interface [polypeptide binding]; other site
1036673010003	putative Zn2+ binding site [ion binding]; other site
1036673010004	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1036673010005	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1036673010006	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1036673010007	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1036673010008	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1036673010009	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1036673010010	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1036673010011	Walker A/P-loop; other site
1036673010012	ATP binding site [chemical binding]; other site
1036673010013	Q-loop/lid; other site
1036673010014	ABC transporter signature motif; other site
1036673010015	Walker B; other site
1036673010016	D-loop; other site
1036673010017	H-loop/switch region; other site
1036673010018	TOBE domain; Region: TOBE_2; pfam08402
1036673010019	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673010020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673010021	dimer interface [polypeptide binding]; other site
1036673010022	putative PBP binding loops; other site
1036673010023	ABC-ATPase subunit interface; other site
1036673010024	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673010025	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673010026	dimer interface [polypeptide binding]; other site
1036673010027	conserved gate region; other site
1036673010028	ABC-ATPase subunit interface; other site
1036673010029	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673010030	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1036673010031	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1036673010032	Glycerophosphodiester phosphodiesterase domain of putative Agrobacterium tumefaciens glycerophosphodiester phosphodiesterase and similar proteins; Region: GDPD_pAtGDE_like; cd08565
1036673010033	active site
1036673010034	catalytic site [active]
1036673010035	metal binding site [ion binding]; metal-binding site
1036673010036	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1036673010037	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1036673010038	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673010039	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673010040	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673010041	dimer interface [polypeptide binding]; other site
1036673010042	ABC-ATPase subunit interface; other site
1036673010043	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673010044	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673010045	dimer interface [polypeptide binding]; other site
1036673010046	conserved gate region; other site
1036673010047	putative PBP binding loops; other site
1036673010048	ABC-ATPase subunit interface; other site
1036673010049	Fibronectin-binding protein (FBP); Region: FBP; pfam07299
1036673010050	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1036673010051	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673010052	Coenzyme A binding pocket [chemical binding]; other site
1036673010053	Predicted membrane protein [Function unknown]; Region: COG2311
1036673010054	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1036673010055	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1036673010056	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1036673010057	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673010058	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673010059	short chain dehydrogenase; Provisional; Region: PRK12747
1036673010060	tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362
1036673010061	NADP binding site [chemical binding]; other site
1036673010062	homodimer interface [polypeptide binding]; other site
1036673010063	active site
1036673010064	substrate binding site [chemical binding]; other site
1036673010065	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
1036673010066	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673010067	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
1036673010068	DoxX-like family; Region: DoxX_2; pfam13564
1036673010069	Transposase domain (DUF772); Region: DUF772; pfam05598
1036673010070	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1036673010071	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1036673010072	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
1036673010073	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1036673010074	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1036673010075	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1036673010076	conserved cys residue [active]
1036673010077	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1036673010078	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
1036673010079	putative dimer interface [polypeptide binding]; other site
1036673010080	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673010081	ligand binding site [chemical binding]; other site
1036673010082	Zn binding site [ion binding]; other site
1036673010083	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1036673010084	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673010085	Coenzyme A binding pocket [chemical binding]; other site
1036673010086	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673010087	H+ Antiporter protein; Region: 2A0121; TIGR00900
1036673010088	putative substrate translocation pore; other site
1036673010089	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
1036673010090	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1036673010091	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673010092	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1036673010093	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1036673010094	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1036673010095	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1036673010096	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1036673010097	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1036673010098	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
1036673010099	hypothetical protein; Provisional; Region: PRK09739
1036673010100	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1036673010101	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673010102	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1036673010103	NAD(P) binding site [chemical binding]; other site
1036673010104	active site
1036673010105	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1036673010106	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1036673010107	DNA binding residues [nucleotide binding]
1036673010108	putative dimer interface [polypeptide binding]; other site
1036673010109	DinB superfamily; Region: DinB_2; pfam12867
1036673010110	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673010111	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673010112	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
1036673010113	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1036673010114	homotrimer interaction site [polypeptide binding]; other site
1036673010115	putative active site [active]
1036673010116	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673010117	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673010118	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1036673010119	Glycosyl hydrolase family 49; Region: Glyco_hydro_49; pfam03718
1036673010120	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673010121	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673010122	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673010123	putative PBP binding loops; other site
1036673010124	dimer interface [polypeptide binding]; other site
1036673010125	ABC-ATPase subunit interface; other site
1036673010126	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673010127	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673010128	dimer interface [polypeptide binding]; other site
1036673010129	conserved gate region; other site
1036673010130	putative PBP binding loops; other site
1036673010131	ABC-ATPase subunit interface; other site
1036673010132	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673010133	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1036673010134	Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179
1036673010135	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1036673010136	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1036673010137	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1036673010138	Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174
1036673010139	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673010140	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673010141	DNA binding site [nucleotide binding]
1036673010142	domain linker motif; other site
1036673010143	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673010144	dimerization interface [polypeptide binding]; other site
1036673010145	ligand binding site [chemical binding]; other site
1036673010146	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673010147	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673010148	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673010149	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673010150	dimer interface [polypeptide binding]; other site
1036673010151	conserved gate region; other site
1036673010152	putative PBP binding loops; other site
1036673010153	ABC-ATPase subunit interface; other site
1036673010154	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673010155	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673010156	dimer interface [polypeptide binding]; other site
1036673010157	conserved gate region; other site
1036673010158	putative PBP binding loops; other site
1036673010159	ABC-ATPase subunit interface; other site
1036673010160	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1036673010161	S-layer homology domain; Region: SLH; pfam00395
1036673010162	S-layer homology domain; Region: SLH; pfam00395
1036673010163	S-layer homology domain; Region: SLH; pfam00395
1036673010164	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1036673010165	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
1036673010166	active site
1036673010167	catalytic residues [active]
1036673010168	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1036673010169	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1036673010170	metal binding site [ion binding]; metal-binding site
1036673010171	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1036673010172	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1036673010173	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673010174	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673010175	active site
1036673010176	phosphorylation site [posttranslational modification]
1036673010177	intermolecular recognition site; other site
1036673010178	dimerization interface [polypeptide binding]; other site
1036673010179	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673010180	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673010181	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673010182	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673010183	dimerization interface [polypeptide binding]; other site
1036673010184	Histidine kinase; Region: His_kinase; pfam06580
1036673010185	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673010186	ATP binding site [chemical binding]; other site
1036673010187	Mg2+ binding site [ion binding]; other site
1036673010188	G-X-G motif; other site
1036673010189	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673010190	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673010191	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1036673010192	lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175
1036673010193	active site
1036673010194	active site
1036673010195	catalytic residues [active]
1036673010196	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1036673010197	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1036673010198	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673010199	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1036673010200	active site
1036673010201	metal binding site [ion binding]; metal-binding site
1036673010202	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673010203	Interdomain contacts; other site
1036673010204	Cytokine receptor motif; other site
1036673010205	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673010206	Interdomain contacts; other site
1036673010207	Cytokine receptor motif; other site
1036673010208	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673010209	Interdomain contacts; other site
1036673010210	Cytokine receptor motif; other site
1036673010211	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1036673010212	dockerin binding interface; other site
1036673010213	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1036673010214	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1036673010215	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1036673010216	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1036673010217	BCCT family transporter; Region: BCCT; pfam02028
1036673010218	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1036673010219	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1036673010220	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1036673010221	B12 binding domain; Region: B12-binding_2; pfam02607
1036673010222	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065
1036673010223	B12 binding site [chemical binding]; other site
1036673010224	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1036673010225	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1036673010226	active site
1036673010227	tetramer interface; other site
1036673010228	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
1036673010229	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1036673010230	active site
1036673010231	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
1036673010232	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673010233	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673010234	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1036673010235	putative dimerization interface [polypeptide binding]; other site
1036673010236	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453
1036673010237	L-asparaginase II; Region: Asparaginase_II; pfam06089
1036673010238	Protein of unknown function (DUF964); Region: DUF964; cl01483
1036673010239	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1036673010240	Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625
1036673010241	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
1036673010242	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673010243	ATP binding site [chemical binding]; other site
1036673010244	putative Mg++ binding site [ion binding]; other site
1036673010245	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673010246	nucleotide binding region [chemical binding]; other site
1036673010247	ATP-binding site [chemical binding]; other site
1036673010248	Staphylococcal nuclease homologues; Region: SNc; smart00318
1036673010249	Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175
1036673010250	Catalytic site; other site
1036673010251	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1036673010252	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1036673010253	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1036673010254	active site
1036673010255	HIGH motif; other site
1036673010256	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1036673010257	tRNA binding surface [nucleotide binding]; other site
1036673010258	anticodon binding site; other site
1036673010259	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673010260	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673010261	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673010262	FOG: CBS domain [General function prediction only]; Region: COG0517
1036673010263	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622
1036673010264	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1036673010265	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
1036673010266	metal binding site [ion binding]; metal-binding site
1036673010267	dimer interface [polypeptide binding]; other site
1036673010268	YugN-like family; Region: YugN; pfam08868
1036673010269	cell division protein FtsW; Region: ftsW; TIGR02614
1036673010270	Asp23 family; Region: Asp23; pfam03780
1036673010271	calcium/proton exchanger (cax); Region: cax; TIGR00378
1036673010272	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1036673010273	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1036673010274	hypothetical protein; Provisional; Region: PRK13666
1036673010275	PTS HPr component phosphorylation site; Region: PTS-HPr; pfam00381
1036673010276	regulatory protein interface [polypeptide binding]; other site
1036673010277	regulatory phosphorylation site [posttranslational modification]; other site
1036673010278	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1036673010279	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1036673010280	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1036673010281	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1036673010282	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1036673010283	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1036673010284	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036673010285	RNA binding surface [nucleotide binding]; other site
1036673010286	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1036673010287	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1036673010288	active site
1036673010289	HIGH motif; other site
1036673010290	dimer interface [polypeptide binding]; other site
1036673010291	KMSKS motif; other site
1036673010292	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036673010293	RNA binding surface [nucleotide binding]; other site
1036673010294	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1036673010295	Transglycosylase; Region: Transgly; pfam00912
1036673010296	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1036673010297	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673010298	Interdomain contacts; other site
1036673010299	Cytokine receptor motif; other site
1036673010300	acetyl-CoA synthetase; Provisional; Region: PRK04319
1036673010301	Domain of unknown function (DUF3448); Region: DUF3448; pfam11930
1036673010302	Uncharacterized subfamily of Acetyl-CoA synthetase like family (ACS); Region: MACS_like_4; cd05969
1036673010303	active site
1036673010304	acyl-activating enzyme (AAE) consensus motif; other site
1036673010305	putative CoA binding site [chemical binding]; other site
1036673010306	AMP binding site [chemical binding]; other site
1036673010307	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1036673010308	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1036673010309	active site
1036673010310	Zn binding site [ion binding]; other site
1036673010311	glycyl-tRNA synthetase; Provisional; Region: PRK04173
1036673010312	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1036673010313	motif 1; other site
1036673010314	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
1036673010315	active site
1036673010316	motif 2; other site
1036673010317	motif 3; other site
1036673010318	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
1036673010319	anticodon binding site; other site
1036673010320	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1036673010321	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1036673010322	catabolite control protein A; Region: ccpA; TIGR01481
1036673010323	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673010324	DNA binding site [nucleotide binding]
1036673010325	domain linker motif; other site
1036673010326	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1036673010327	dimerization interface [polypeptide binding]; other site
1036673010328	effector binding site; other site
1036673010329	Predicted integral membrane protein [Function unknown]; Region: COG5652
1036673010330	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1036673010331	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1036673010332	proposed catalytic triad [active]
1036673010333	conserved cys residue [active]
1036673010334	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1036673010335	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1036673010336	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1036673010337	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1036673010338	PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255
1036673010339	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1036673010340	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1036673010341	active site turn [active]
1036673010342	phosphorylation site [posttranslational modification]
1036673010343	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1036673010344	HPr interaction site; other site
1036673010345	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1036673010346	active site
1036673010347	phosphorylation site [posttranslational modification]
1036673010348	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1036673010349	thiamine phosphate binding site [chemical binding]; other site
1036673010350	active site
1036673010351	pyrophosphate binding site [ion binding]; other site
1036673010352	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1036673010353	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
1036673010354	putative active site [active]
1036673010355	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1036673010356	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1036673010357	hinge; other site
1036673010358	active site
1036673010359	CrcB-like protein; Region: CRCB; cl09114
1036673010360	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
1036673010361	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1036673010362	active site residue [active]
1036673010363	shikimate kinase; Reviewed; Region: aroK; PRK00131
1036673010364	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1036673010365	ADP binding site [chemical binding]; other site
1036673010366	magnesium binding site [ion binding]; other site
1036673010367	putative shikimate binding site; other site
1036673010368	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1036673010369	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1036673010370	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1036673010371	D-mannonate oxidoreductase; Provisional; Region: PRK08277
1036673010372	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673010373	NAD(P) binding site [chemical binding]; other site
1036673010374	active site
1036673010375	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
1036673010376	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
1036673010377	N- and C-terminal domain interface [polypeptide binding]; other site
1036673010378	active site
1036673010379	catalytic site [active]
1036673010380	metal binding site [ion binding]; metal-binding site
1036673010381	carbohydrate binding site [chemical binding]; other site
1036673010382	ATP binding site [chemical binding]; other site
1036673010383	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
1036673010384	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673010385	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673010386	DNA binding site [nucleotide binding]
1036673010387	domain linker motif; other site
1036673010388	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673010389	dimerization interface [polypeptide binding]; other site
1036673010390	ligand binding site [chemical binding]; other site
1036673010391	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
1036673010392	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
1036673010393	active site
1036673010394	Na/Ca binding site [ion binding]; other site
1036673010395	catalytic site [active]
1036673010396	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
1036673010397	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673010398	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493
1036673010399	Protein of unknown function (DUF1054); Region: DUF1054; pfam06335
1036673010400	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1036673010401	active site
1036673010402	catalytic triad [active]
1036673010403	oxyanion hole [active]
1036673010404	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1036673010405	metal binding site [ion binding]; metal-binding site
1036673010406	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673010407	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673010408	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673010409	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673010410	dimer interface [polypeptide binding]; other site
1036673010411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673010412	ABC-ATPase subunit interface; other site
1036673010413	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673010414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673010415	dimer interface [polypeptide binding]; other site
1036673010416	conserved gate region; other site
1036673010417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673010418	ABC-ATPase subunit interface; other site
1036673010419	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673010420	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673010421	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673010422	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673010423	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1036673010424	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1036673010425	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673010426	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673010427	putative substrate translocation pore; other site
1036673010428	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1036673010429	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
1036673010430	homodimer interface [polypeptide binding]; other site
1036673010431	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673010432	catalytic residue [active]
1036673010433	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
1036673010434	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
1036673010435	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673010436	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673010437	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1036673010438	active site
1036673010439	motif I; other site
1036673010440	motif II; other site
1036673010441	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673010442	Domain of unknown function (DUF1885); Region: DUF1885; pfam08968
1036673010443	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
1036673010444	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673010445	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1036673010446	Arginase family; Region: Arginase; cd09989
1036673010447	active site
1036673010448	Mn binding site [ion binding]; other site
1036673010449	oligomer interface [polypeptide binding]; other site
1036673010450	Protein of unknown function (DUF3892); Region: DUF3892; pfam13031
1036673010451	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1036673010452	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1036673010453	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673010454	dimerization interface [polypeptide binding]; other site
1036673010455	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673010456	dimer interface [polypeptide binding]; other site
1036673010457	putative CheW interface [polypeptide binding]; other site
1036673010458	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673010459	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673010460	metal binding site [ion binding]; metal-binding site
1036673010461	active site
1036673010462	I-site; other site
1036673010463	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673010464	dimer interface [polypeptide binding]; other site
1036673010465	phosphorylation site [posttranslational modification]
1036673010466	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673010467	ATP binding site [chemical binding]; other site
1036673010468	Mg2+ binding site [ion binding]; other site
1036673010469	G-X-G motif; other site
1036673010470	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1036673010471	GTP binding site; other site
1036673010472	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1036673010473	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1036673010474	ligand binding site [chemical binding]; other site
1036673010475	flexible hinge region; other site
1036673010476	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1036673010477	putative switch regulator; other site
1036673010478	non-specific DNA interactions [nucleotide binding]; other site
1036673010479	DNA binding site [nucleotide binding]
1036673010480	sequence specific DNA binding site [nucleotide binding]; other site
1036673010481	putative cAMP binding site [chemical binding]; other site
1036673010482	Protein of unknown function (DUF1811); Region: DUF1811; pfam08838
1036673010483	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1036673010484	Phosphotransferase enzyme family; Region: APH; pfam01636
1036673010485	active site
1036673010486	substrate binding site [chemical binding]; other site
1036673010487	ATP binding site [chemical binding]; other site
1036673010488	PilZ domain; Region: PilZ; pfam07238
1036673010489	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1036673010490	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
1036673010491	active site
1036673010492	DNA binding site [nucleotide binding]
1036673010493	The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424
1036673010494	DNA binding site [nucleotide binding]
1036673010495	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1036673010496	putative deacylase active site [active]
1036673010497	Domain of unknown function (DUF3973); Region: DUF3973; pfam13119
1036673010498	WYL domain; Region: WYL; cl14852
1036673010499	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673010500	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1036673010501	active site
1036673010502	metal binding site [ion binding]; metal-binding site
1036673010503	Protein of unknown function (DUF2772); Region: DUF2772; pfam10970
1036673010504	Spore germination protein GerPC; Region: GerPC; pfam10737
1036673010505	Protein of unknown function (DUF2539); Region: DUF2539; pfam10803
1036673010506	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1036673010507	endonuclease subunit; Provisional; Region: 47; PHA02546
1036673010508	Spore germination protein gerPA/gerPF; Region: gerPA; pfam10676
1036673010509	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1036673010510	tetramer interfaces [polypeptide binding]; other site
1036673010511	binuclear metal-binding site [ion binding]; other site
1036673010512	hypothetical protein; Provisional; Region: PRK13679
1036673010513	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1036673010514	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1036673010515	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1036673010516	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036673010517	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1036673010518	Protein export membrane protein; Region: SecD_SecF; cl14618
1036673010519	Protein export membrane protein; Region: SecD_SecF; cl14618
1036673010520	Predicted transcriptional regulators [Transcription]; Region: COG1510
1036673010521	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673010522	putative DNA binding site [nucleotide binding]; other site
1036673010523	putative Zn2+ binding site [ion binding]; other site
1036673010524	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
1036673010525	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673010526	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673010527	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036673010528	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036673010529	Walker A/P-loop; other site
1036673010530	ATP binding site [chemical binding]; other site
1036673010531	Q-loop/lid; other site
1036673010532	ABC transporter signature motif; other site
1036673010533	Walker B; other site
1036673010534	D-loop; other site
1036673010535	H-loop/switch region; other site
1036673010536	FtsX-like permease family; Region: FtsX; pfam02687
1036673010537	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1036673010538	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036673010539	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036673010540	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036673010541	Walker A/P-loop; other site
1036673010542	ATP binding site [chemical binding]; other site
1036673010543	Q-loop/lid; other site
1036673010544	ABC transporter signature motif; other site
1036673010545	Walker B; other site
1036673010546	D-loop; other site
1036673010547	H-loop/switch region; other site
1036673010548	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673010549	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673010550	dimer interface [polypeptide binding]; other site
1036673010551	putative CheW interface [polypeptide binding]; other site
1036673010552	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1036673010553	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
1036673010554	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1036673010555	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1036673010556	putative dimer interface [polypeptide binding]; other site
1036673010557	putative anticodon binding site; other site
1036673010558	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1036673010559	homodimer interface [polypeptide binding]; other site
1036673010560	motif 1; other site
1036673010561	motif 2; other site
1036673010562	active site
1036673010563	motif 3; other site
1036673010564	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1036673010565	propionate/acetate kinase; Provisional; Region: PRK12379
1036673010566	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808
1036673010567	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1036673010568	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1036673010569	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1036673010570	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1036673010571	substrate binding site [chemical binding]; other site
1036673010572	ligand binding site [chemical binding]; other site
1036673010573	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673010574	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673010575	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673010576	dimerization interface [polypeptide binding]; other site
1036673010577	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1036673010578	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
1036673010579	putative active site [active]
1036673010580	catalytic triad [active]
1036673010581	putative dimer interface [polypeptide binding]; other site
1036673010582	transaminase; Reviewed; Region: PRK08068
1036673010583	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673010584	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673010585	homodimer interface [polypeptide binding]; other site
1036673010586	catalytic residue [active]
1036673010587	gamma-glutamyl kinase; Provisional; Region: PRK05429
1036673010588	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1036673010589	nucleotide binding site [chemical binding]; other site
1036673010590	homotetrameric interface [polypeptide binding]; other site
1036673010591	putative phosphate binding site [ion binding]; other site
1036673010592	putative allosteric binding site; other site
1036673010593	PUA domain; Region: PUA; pfam01472
1036673010594	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1036673010595	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1036673010596	putative catalytic cysteine [active]
1036673010597	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673010598	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1036673010599	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1036673010600	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549
1036673010601	2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209
1036673010602	dimer interface [polypeptide binding]; other site
1036673010603	active site
1036673010604	catalytic residue [active]
1036673010605	metal binding site [ion binding]; metal-binding site
1036673010606	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1036673010607	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
1036673010608	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1036673010609	intersubunit interface [polypeptide binding]; other site
1036673010610	active site
1036673010611	Zn2+ binding site [ion binding]; other site
1036673010612	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
1036673010613	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1036673010614	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1036673010615	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1036673010616	Walker A/P-loop; other site
1036673010617	ATP binding site [chemical binding]; other site
1036673010618	Q-loop/lid; other site
1036673010619	ABC transporter signature motif; other site
1036673010620	Walker B; other site
1036673010621	D-loop; other site
1036673010622	H-loop/switch region; other site
1036673010623	RNA polymerase sigma factor SigX; Provisional; Region: PRK09639
1036673010624	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673010625	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673010626	DNA binding residues [nucleotide binding]
1036673010627	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036673010628	active site
1036673010629	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1036673010630	active site
1036673010631	dimer interface [polypeptide binding]; other site
1036673010632	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1036673010633	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1036673010634	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1036673010635	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1036673010636	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1036673010637	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1036673010638	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1036673010639	IMP binding site; other site
1036673010640	dimer interface [polypeptide binding]; other site
1036673010641	interdomain contacts; other site
1036673010642	partial ornithine binding site; other site
1036673010643	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1036673010644	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1036673010645	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1036673010646	catalytic site [active]
1036673010647	subunit interface [polypeptide binding]; other site
1036673010648	dihydroorotase; Validated; Region: pyrC; PRK09357
1036673010649	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1036673010650	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1036673010651	active site
1036673010652	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1036673010653	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1036673010654	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1036673010655	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1036673010656	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036673010657	active site
1036673010658	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1036673010659	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1036673010660	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1036673010661	putative trimer interface [polypeptide binding]; other site
1036673010662	putative CoA binding site [chemical binding]; other site
1036673010663	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
1036673010664	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1036673010665	metal binding site [ion binding]; metal-binding site
1036673010666	putative dimer interface [polypeptide binding]; other site
1036673010667	aminotransferase A; Validated; Region: PRK07683
1036673010668	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673010669	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673010670	homodimer interface [polypeptide binding]; other site
1036673010671	catalytic residue [active]
1036673010672	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1036673010673	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036673010674	RNA binding surface [nucleotide binding]; other site
1036673010675	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1036673010676	active site
1036673010677	lipoprotein signal peptidase; Provisional; Region: PRK14787
1036673010678	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
1036673010679	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1036673010680	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1036673010681	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1036673010682	HIGH motif; other site
1036673010683	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1036673010684	active site
1036673010685	KMSKS motif; other site
1036673010686	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1036673010687	tRNA binding surface [nucleotide binding]; other site
1036673010688	anticodon binding site; other site
1036673010689	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1036673010690	DivIVA protein; Region: DivIVA; pfam05103
1036673010691	DivIVA domain; Region: DivI1A_domain; TIGR03544
1036673010692	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1036673010693	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036673010694	RNA binding surface [nucleotide binding]; other site
1036673010695	YGGT family; Region: YGGT; pfam02325
1036673010696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
1036673010697	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1036673010698	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1036673010699	catalytic residue [active]
1036673010700	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1036673010701	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1036673010702	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
1036673010703	sporulation sigma factor SigG; Reviewed; Region: PRK08215
1036673010704	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673010705	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1036673010706	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673010707	DNA binding residues [nucleotide binding]
1036673010708	sporulation sigma factor SigE; Reviewed; Region: PRK08301
1036673010709	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673010710	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673010711	DNA binding residues [nucleotide binding]
1036673010712	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
1036673010713	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
1036673010714	cell division protein FtsZ; Validated; Region: PRK09330
1036673010715	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1036673010716	nucleotide binding site [chemical binding]; other site
1036673010717	SulA interaction site; other site
1036673010718	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1036673010719	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1036673010720	nucleotide binding site [chemical binding]; other site
1036673010721	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
1036673010722	Cell division protein FtsA; Region: FtsA; pfam14450
1036673010723	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1036673010724	Cell division protein FtsQ; Region: FtsQ; pfam03799
1036673010725	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1036673010726	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1036673010727	hinge; other site
1036673010728	active site
1036673010729	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1036673010730	FAD binding domain; Region: FAD_binding_4; pfam01565
1036673010731	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1036673010732	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446
1036673010733	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1036673010734	active site
1036673010735	homodimer interface [polypeptide binding]; other site
1036673010736	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
1036673010737	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1036673010738	TrkA-N domain; Region: TrkA_N; pfam02254
1036673010739	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1036673010740	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1036673010741	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1036673010742	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1036673010743	Mg++ binding site [ion binding]; other site
1036673010744	putative catalytic motif [active]
1036673010745	putative substrate binding site [chemical binding]; other site
1036673010746	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1036673010747	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1036673010748	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1036673010749	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1036673010750	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1036673010751	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1036673010752	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1036673010753	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1036673010754	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
1036673010755	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1036673010756	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1036673010757	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
1036673010758	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1036673010759	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1036673010760	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1036673010761	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1036673010762	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
1036673010763	Cell division protein FtsL; Region: FtsL; cl11433
1036673010764	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1036673010765	MraW methylase family; Region: Methyltransf_5; pfam01795
1036673010766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001
1036673010767	MraZ protein; Region: MraZ; pfam02381
1036673010768	MraZ protein; Region: MraZ; pfam02381
1036673010769	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
1036673010770	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1036673010771	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1036673010772	homotetramer interface [polypeptide binding]; other site
1036673010773	ligand binding site [chemical binding]; other site
1036673010774	catalytic site [active]
1036673010775	NAD binding site [chemical binding]; other site
1036673010776	bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998
1036673010777	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
1036673010778	Protein of unknown function (DUF4085); Region: DUF4085; pfam13315
1036673010779	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
1036673010780	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673010781	Walker A/P-loop; other site
1036673010782	ATP binding site [chemical binding]; other site
1036673010783	Q-loop/lid; other site
1036673010784	ABC transporter signature motif; other site
1036673010785	Walker B; other site
1036673010786	D-loop; other site
1036673010787	H-loop/switch region; other site
1036673010788	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1036673010789	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1036673010790	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673010791	Walker A/P-loop; other site
1036673010792	ATP binding site [chemical binding]; other site
1036673010793	Q-loop/lid; other site
1036673010794	ABC transporter signature motif; other site
1036673010795	Walker B; other site
1036673010796	D-loop; other site
1036673010797	H-loop/switch region; other site
1036673010798	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1036673010799	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1036673010800	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1036673010801	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673010802	dimer interface [polypeptide binding]; other site
1036673010803	conserved gate region; other site
1036673010804	putative PBP binding loops; other site
1036673010805	ABC-ATPase subunit interface; other site
1036673010806	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1036673010807	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673010808	dimer interface [polypeptide binding]; other site
1036673010809	conserved gate region; other site
1036673010810	putative PBP binding loops; other site
1036673010811	ABC-ATPase subunit interface; other site
1036673010812	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1036673010813	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1036673010814	peptide binding site [polypeptide binding]; other site
1036673010815	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
1036673010816	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1036673010817	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
1036673010818	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1036673010819	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
1036673010820	Protein of unknown function (DUF2626); Region: DUF2626; pfam11117
1036673010821	Uncharacterized conserved protein [Function unknown]; Region: COG1565
1036673010822	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
1036673010823	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
1036673010824	putative active site [active]
1036673010825	PhoH-like protein; Region: PhoH; pfam02562
1036673010826	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
1036673010827	YlaH-like protein; Region: YlaH; pfam14036
1036673010828	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1036673010829	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1036673010830	G1 box; other site
1036673010831	putative GEF interaction site [polypeptide binding]; other site
1036673010832	GTP/Mg2+ binding site [chemical binding]; other site
1036673010833	Switch I region; other site
1036673010834	G2 box; other site
1036673010835	G3 box; other site
1036673010836	Switch II region; other site
1036673010837	G4 box; other site
1036673010838	G5 box; other site
1036673010839	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1036673010840	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1036673010841	integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717
1036673010842	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1036673010843	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1036673010844	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1036673010845	Ligand Binding Site [chemical binding]; other site
1036673010846	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1036673010847	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1036673010848	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036673010849	catalytic residue [active]
1036673010850	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1036673010851	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1036673010852	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1036673010853	catalytic residue [active]
1036673010854	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
1036673010855	Protein of unknown function (DUF3907); Region: DUF3907; pfam13047
1036673010856	Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484
1036673010857	active site
1036673010858	catalytic triad [active]
1036673010859	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1036673010860	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1036673010861	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
1036673010862	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1036673010863	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1036673010864	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1036673010865	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1036673010866	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1036673010867	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673010868	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1036673010869	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673010870	DNA binding residues [nucleotide binding]
1036673010871	DNA primase; Validated; Region: dnaG; PRK05667
1036673010872	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1036673010873	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1036673010874	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1036673010875	active site
1036673010876	metal binding site [ion binding]; metal-binding site
1036673010877	interdomain interaction site; other site
1036673010878	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1036673010879	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727
1036673010880	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
1036673010881	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1036673010882	Recombination protein O N terminal; Region: RecO_N; pfam11967
1036673010883	Recombination protein O C terminal; Region: RecO_C; pfam02565
1036673010884	YqzL-like protein; Region: YqzL; pfam14006
1036673010885	GTPase Era; Reviewed; Region: era; PRK00089
1036673010886	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1036673010887	G1 box; other site
1036673010888	GTP/Mg2+ binding site [chemical binding]; other site
1036673010889	Switch I region; other site
1036673010890	G2 box; other site
1036673010891	Switch II region; other site
1036673010892	G3 box; other site
1036673010893	G4 box; other site
1036673010894	G5 box; other site
1036673010895	KH domain; Region: KH_2; pfam07650
1036673010896	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1036673010897	active site
1036673010898	catalytic motif [active]
1036673010899	Zn binding site [ion binding]; other site
1036673010900	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
1036673010901	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1036673010902	active site
1036673010903	metal-binding heat shock protein; Provisional; Region: PRK00016
1036673010904	Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480
1036673010905	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
1036673010906	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036673010907	Zn2+ binding site [ion binding]; other site
1036673010908	Mg2+ binding site [ion binding]; other site
1036673010909	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1036673010910	PhoH-like protein; Region: PhoH; pfam02562
1036673010911	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
1036673010912	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
1036673010913	YabP family; Region: YabP; cl06766
1036673010914	hypothetical protein; Provisional; Region: PRK13665
1036673010915	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021
1036673010916	active site residues [active]
1036673010917	dimer interface [polypeptide binding]; other site
1036673010918	NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686
1036673010919	Yqey-like protein; Region: YqeY; pfam09424
1036673010920	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
1036673010921	nucleotide binding site/active site [active]
1036673010922	HIT family signature motif; other site
1036673010923	catalytic residue [active]
1036673010924	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673010925	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673010926	Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593
1036673010927	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036673010928	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
1036673010929	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673010930	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
1036673010931	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673010932	ABC transporter signature motif; other site
1036673010933	Walker B; other site
1036673010934	D-loop; other site
1036673010935	H-loop/switch region; other site
1036673010936	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1036673010937	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673010938	active site
1036673010939	metal binding site [ion binding]; metal-binding site
1036673010940	DNA binding site [nucleotide binding]
1036673010941	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
1036673010942	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1036673010943	Part of AAA domain; Region: AAA_19; pfam13245
1036673010944	Family description; Region: UvrD_C_2; pfam13538
1036673010945	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1036673010946	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
1036673010947	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1036673010948	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1036673010949	putative FMN binding site [chemical binding]; other site
1036673010950	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1036673010951	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1036673010952	putative RNA binding site [nucleotide binding]; other site
1036673010953	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673010954	S-adenosylmethionine binding site [chemical binding]; other site
1036673010955	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
1036673010956	active site
1036673010957	Ap6A binding site [chemical binding]; other site
1036673010958	nudix motif; other site
1036673010959	metal binding site [ion binding]; metal-binding site
1036673010960	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1036673010961	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1036673010962	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673010963	FeS/SAM binding site; other site
1036673010964	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1036673010965	RNA methyltransferase, RsmE family; Region: TIGR00046
1036673010966	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
1036673010967	Peptidase family M50; Region: Peptidase_M50; pfam02163
1036673010968	active site
1036673010969	putative substrate binding region [chemical binding]; other site
1036673010970	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1036673010971	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673010972	S-adenosylmethionine binding site [chemical binding]; other site
1036673010973	YfhD-like protein; Region: YfhD; pfam14151
1036673010974	chaperone protein DnaJ; Provisional; Region: PRK14280
1036673010975	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1036673010976	HSP70 interaction site [polypeptide binding]; other site
1036673010977	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1036673010978	substrate binding site [polypeptide binding]; other site
1036673010979	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1036673010980	Zn binding sites [ion binding]; other site
1036673010981	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1036673010982	dimer interface [polypeptide binding]; other site
1036673010983	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1036673010984	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1036673010985	nucleotide binding site [chemical binding]; other site
1036673010986	NEF interaction site [polypeptide binding]; other site
1036673010987	SBD interface [polypeptide binding]; other site
1036673010988	GrpE; Region: GrpE; pfam01025
1036673010989	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1036673010990	dimer interface [polypeptide binding]; other site
1036673010991	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1036673010992	chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309
1036673010993	thermosome, various subunits, archaeal; Region: thermosome_arch; TIGR02339
1036673010994	ATP/Mg binding site [chemical binding]; other site
1036673010995	ring oligomerisation interface [polypeptide binding]; other site
1036673010996	hinge regions; other site
1036673010997	stacking interactions; other site
1036673010998	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1036673010999	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1036673011000	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1036673011001	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673011002	Coenzyme A binding pocket [chemical binding]; other site
1036673011003	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1036673011004	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673011005	FeS/SAM binding site; other site
1036673011006	HemN C-terminal domain; Region: HemN_C; pfam06969
1036673011007	GTP-binding protein LepA; Provisional; Region: PRK05433
1036673011008	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1036673011009	G1 box; other site
1036673011010	putative GEF interaction site [polypeptide binding]; other site
1036673011011	GTP/Mg2+ binding site [chemical binding]; other site
1036673011012	Switch I region; other site
1036673011013	G2 box; other site
1036673011014	G3 box; other site
1036673011015	Switch II region; other site
1036673011016	G4 box; other site
1036673011017	G5 box; other site
1036673011018	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1036673011019	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1036673011020	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1036673011021	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
1036673011022	stage II sporulation protein P; Region: spore_II_P; TIGR02867
1036673011023	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673011024	putative CheW interface [polypeptide binding]; other site
1036673011025	germination protease; Provisional; Region: PRK02858
1036673011026	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1036673011027	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1036673011028	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1036673011029	Putative zinc-finger; Region: zf-HC2; pfam13490
1036673011030	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
1036673011031	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673011032	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673011033	DNA binding residues [nucleotide binding]
1036673011034	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1036673011035	EamA-like transporter family; Region: EamA; pfam00892
1036673011036	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1036673011037	Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530
1036673011038	[2Fe-2S] cluster binding site [ion binding]; other site
1036673011039	NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251
1036673011040	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036673011041	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1036673011042	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
1036673011043	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1036673011044	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1036673011045	DNA internalization-related competence protein ComEC/Rec2; Region: ComEC_Rec2; TIGR00361
1036673011046	Competence protein; Region: Competence; pfam03772
1036673011047	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036673011048	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1036673011049	catalytic motif [active]
1036673011050	Zn binding site [ion binding]; other site
1036673011051	Helix-hairpin-helix motif; Region: HHH; pfam00633
1036673011052	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
1036673011053	late competence protein ComER; Validated; Region: PRK07680
1036673011054	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1036673011055	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1036673011056	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1036673011057	HIGH motif; other site
1036673011058	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1036673011059	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1036673011060	active site
1036673011061	KMSKS motif; other site
1036673011062	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1036673011063	tRNA binding surface [nucleotide binding]; other site
1036673011064	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036673011065	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673011066	S-adenosylmethionine binding site [chemical binding]; other site
1036673011067	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1036673011068	S1 domain; Region: S1_2; pfam13509
1036673011069	S1 domain; Region: S1_2; pfam13509
1036673011070	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1036673011071	putative DNA binding site [nucleotide binding]; other site
1036673011072	putative Zn2+ binding site [ion binding]; other site
1036673011073	Oligomerisation domain; Region: Oligomerisation; cl00519
1036673011074	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036673011075	Zn2+ binding site [ion binding]; other site
1036673011076	Mg2+ binding site [ion binding]; other site
1036673011077	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1036673011078	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1036673011079	active site
1036673011080	(T/H)XGH motif; other site
1036673011081	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
1036673011082	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1036673011083	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1036673011084	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1036673011085	shikimate binding site; other site
1036673011086	NAD(P) binding site [chemical binding]; other site
1036673011087	GTPase YqeH; Provisional; Region: PRK13796
1036673011088	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1036673011089	GTP/Mg2+ binding site [chemical binding]; other site
1036673011090	G4 box; other site
1036673011091	G5 box; other site
1036673011092	G1 box; other site
1036673011093	Switch I region; other site
1036673011094	G2 box; other site
1036673011095	G3 box; other site
1036673011096	Switch II region; other site
1036673011097	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668; Region: YqeG_hyp_ppase
1036673011098	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673011099	active site
1036673011100	motif I; other site
1036673011101	motif II; other site
1036673011102	Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051
1036673011103	dimanganese center [ion binding]; other site
1036673011104	CotJB protein; Region: CotJB; pfam12652
1036673011105	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
1036673011106	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1036673011107	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1036673011108	Domain of unknown function (DUF4129); Region: DUF4129; pfam13559
1036673011109	Protein of unknown function DUF58; Region: DUF58; pfam01882
1036673011110	MoxR-like ATPases [General function prediction only]; Region: COG0714
1036673011111	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673011112	Walker A motif; other site
1036673011113	ATP binding site [chemical binding]; other site
1036673011114	Walker B motif; other site
1036673011115	arginine finger; other site
1036673011116	SpoVA protein; Region: SpoVA; cl04298
1036673011117	stage V sporulation protein AD; Provisional; Region: PRK12404
1036673011118	Stage V sporulation protein AD (SpoVAD); Region: SpoVAD; pfam07451
1036673011119	SpoVA protein; Region: SpoVA; cl04298
1036673011120	Predicted membrane protein [Function unknown]; Region: COG2323
1036673011121	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1036673011122	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1036673011123	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1036673011124	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1036673011125	putative acyl-acceptor binding pocket; other site
1036673011126	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1036673011127	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1036673011128	ligand binding site [chemical binding]; other site
1036673011129	flexible hinge region; other site
1036673011130	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1036673011131	putative switch regulator; other site
1036673011132	non-specific DNA interactions [nucleotide binding]; other site
1036673011133	DNA binding site [nucleotide binding]
1036673011134	sequence specific DNA binding site [nucleotide binding]; other site
1036673011135	putative cAMP binding site [chemical binding]; other site
1036673011136	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673011137	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673011138	active site
1036673011139	phosphorylation site [posttranslational modification]
1036673011140	intermolecular recognition site; other site
1036673011141	dimerization interface [polypeptide binding]; other site
1036673011142	bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489
1036673011143	Repair protein; Region: Repair_PSII; pfam04536
1036673011144	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036673011145	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673011146	Protein of unknown function (DUF3891); Region: DUF3891; pfam13030
1036673011147	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673011148	Coenzyme A binding pocket [chemical binding]; other site
1036673011149	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673011150	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673011151	DNA binding site [nucleotide binding]
1036673011152	domain linker motif; other site
1036673011153	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673011154	dimerization interface [polypeptide binding]; other site
1036673011155	ligand binding site [chemical binding]; other site
1036673011156	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
1036673011157	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1036673011158	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1036673011159	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036673011160	MULE transposase domain; Region: MULE; pfam10551
1036673011161	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1036673011162	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673011163	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1036673011164	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
1036673011165	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1036673011166	sugar binding site [chemical binding]; other site
1036673011167	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1036673011168	sugar binding site [chemical binding]; other site
1036673011169	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
1036673011170	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
1036673011171	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1036673011172	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673011173	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1036673011174	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1036673011175	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
1036673011176	putative active site [active]
1036673011177	putative metal binding site [ion binding]; other site
1036673011178	BNR repeat-like domain; Region: BNR_2; pfam13088
1036673011179	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
1036673011180	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1036673011181	Carbohydrate binding domain X2; Region: CBM_X2; pfam03442
1036673011182	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1036673011183	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1036673011184	inhibitor binding site; inhibition site
1036673011185	active site
1036673011186	Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730
1036673011187	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1036673011188	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1036673011189	putative sugar binding sites [chemical binding]; other site
1036673011190	Q-X-W motif; other site
1036673011191	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1036673011192	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1036673011193	putative sugar binding sites [chemical binding]; other site
1036673011194	Q-X-W motif; other site
1036673011195	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1036673011196	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1036673011197	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1036673011198	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
1036673011199	ligand binding site [chemical binding]; other site
1036673011200	metal binding site [ion binding]; metal-binding site
1036673011201	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673011202	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673011203	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673011204	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011205	dimer interface [polypeptide binding]; other site
1036673011206	ABC-ATPase subunit interface; other site
1036673011207	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673011208	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011209	dimer interface [polypeptide binding]; other site
1036673011210	conserved gate region; other site
1036673011211	putative PBP binding loops; other site
1036673011212	ABC-ATPase subunit interface; other site
1036673011213	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673011214	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673011215	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673011216	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673011217	active site
1036673011218	phosphorylation site [posttranslational modification]
1036673011219	intermolecular recognition site; other site
1036673011220	dimerization interface [polypeptide binding]; other site
1036673011221	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673011222	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011223	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673011224	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673011225	dimerization interface [polypeptide binding]; other site
1036673011226	Histidine kinase; Region: His_kinase; pfam06580
1036673011227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673011228	ATP binding site [chemical binding]; other site
1036673011229	Mg2+ binding site [ion binding]; other site
1036673011230	G-X-G motif; other site
1036673011231	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1036673011232	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
1036673011233	putative active site [active]
1036673011234	putative metal binding site [ion binding]; other site
1036673011235	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698
1036673011236	Asp-box motif; other site
1036673011237	BNR repeat-like domain; Region: BNR_2; pfam13088
1036673011238	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673011239	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011240	dimer interface [polypeptide binding]; other site
1036673011241	conserved gate region; other site
1036673011242	putative PBP binding loops; other site
1036673011243	ABC-ATPase subunit interface; other site
1036673011244	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
1036673011245	dimer interface [polypeptide binding]; other site
1036673011246	ABC-ATPase subunit interface; other site
1036673011247	putative PBP binding loops; other site
1036673011248	Yip1 domain; Region: Yip1; pfam04893
1036673011249	NHL repeat; Region: NHL; pfam01436
1036673011250	NHL repeat; Region: NHL; pfam01436
1036673011251	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1036673011252	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1036673011253	TPR motif; other site
1036673011254	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673011255	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011256	dimer interface [polypeptide binding]; other site
1036673011257	conserved gate region; other site
1036673011258	ABC-ATPase subunit interface; other site
1036673011259	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011260	dimer interface [polypeptide binding]; other site
1036673011261	conserved gate region; other site
1036673011262	putative PBP binding loops; other site
1036673011263	ABC-ATPase subunit interface; other site
1036673011264	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1036673011265	putative metal binding site [ion binding]; other site
1036673011266	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1036673011267	putative metal binding site [ion binding]; other site
1036673011268	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673011269	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673011270	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673011271	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673011272	Cupin domain; Region: Cupin_2; pfam07883
1036673011273	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011274	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673011275	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011276	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673011277	Erythromycin esterase; Region: Erythro_esteras; cl17110
1036673011278	Erythromycin esterase; Region: Erythro_esteras; pfam05139
1036673011279	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673011280	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673011281	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1036673011282	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1036673011283	trimer interface [polypeptide binding]; other site
1036673011284	Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507
1036673011285	trimer interface [polypeptide binding]; other site
1036673011286	Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962
1036673011287	ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909
1036673011288	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673011289	DNA binding residues [nucleotide binding]
1036673011290	dimerization interface [polypeptide binding]; other site
1036673011291	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673011292	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1036673011293	MAC/Perforin domain; Region: MACPF; cl02616
1036673011294	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1036673011295	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
1036673011296	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673011297	Coenzyme A binding pocket [chemical binding]; other site
1036673011298	beta-D-glucuronidase; Provisional; Region: PRK10150
1036673011299	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1036673011300	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673011301	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1036673011302	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673011303	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011304	dimer interface [polypeptide binding]; other site
1036673011305	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
1036673011306	ABC-ATPase subunit interface; other site
1036673011307	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673011308	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011309	dimer interface [polypeptide binding]; other site
1036673011310	conserved gate region; other site
1036673011311	putative PBP binding loops; other site
1036673011312	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673011313	ABC-ATPase subunit interface; other site
1036673011314	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673011315	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673011316	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011317	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673011318	CoA binding site [chemical binding]; other site
1036673011319	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011320	Condensation domain; Region: Condensation; pfam00668
1036673011321	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011322	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673011323	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673011324	acyl-activating enzyme (AAE) consensus motif; other site
1036673011325	AMP binding site [chemical binding]; other site
1036673011326	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011327	Condensation domain; Region: Condensation; pfam00668
1036673011328	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011329	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673011330	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673011331	acyl-activating enzyme (AAE) consensus motif; other site
1036673011332	AMP binding site [chemical binding]; other site
1036673011333	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011334	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1036673011335	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673011336	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673011337	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673011338	acyl-activating enzyme (AAE) consensus motif; other site
1036673011339	AMP binding site [chemical binding]; other site
1036673011340	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011341	Condensation domain; Region: Condensation; pfam00668
1036673011342	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011343	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673011344	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673011345	acyl-activating enzyme (AAE) consensus motif; other site
1036673011346	AMP binding site [chemical binding]; other site
1036673011347	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011348	Condensation domain; Region: Condensation; pfam00668
1036673011349	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011350	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673011351	Condensation domain; Region: Condensation; pfam00668
1036673011352	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011353	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673011354	Condensation domain; Region: Condensation; pfam00668
1036673011355	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011356	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673011357	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673011358	acyl-activating enzyme (AAE) consensus motif; other site
1036673011359	AMP binding site [chemical binding]; other site
1036673011360	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011361	Condensation domain; Region: Condensation; pfam00668
1036673011362	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011363	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673011364	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673011365	acyl-activating enzyme (AAE) consensus motif; other site
1036673011366	AMP binding site [chemical binding]; other site
1036673011367	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011368	Condensation domain; Region: Condensation; pfam00668
1036673011369	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011370	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673011371	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673011372	acyl-activating enzyme (AAE) consensus motif; other site
1036673011373	AMP binding site [chemical binding]; other site
1036673011374	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011375	Condensation domain; Region: Condensation; pfam00668
1036673011376	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011377	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673011378	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673011379	acyl-activating enzyme (AAE) consensus motif; other site
1036673011380	AMP binding site [chemical binding]; other site
1036673011381	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011382	Condensation domain; Region: Condensation; pfam00668
1036673011383	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673011384	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08314
1036673011385	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673011386	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673011387	acyl-activating enzyme (AAE) consensus motif; other site
1036673011388	AMP binding site [chemical binding]; other site
1036673011389	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011390	Condensation domain; Region: Condensation; pfam00668
1036673011391	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011392	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673011393	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673011394	acyl-activating enzyme (AAE) consensus motif; other site
1036673011395	AMP binding site [chemical binding]; other site
1036673011396	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011397	Condensation domain; Region: Condensation; pfam00668
1036673011398	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011399	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673011400	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673011401	acyl-activating enzyme (AAE) consensus motif; other site
1036673011402	AMP binding site [chemical binding]; other site
1036673011403	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011404	Condensation domain; Region: Condensation; pfam00668
1036673011405	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011406	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673011407	Condensation domain; Region: Condensation; pfam00668
1036673011408	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673011409	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1036673011410	active site
1036673011411	metal binding site [ion binding]; metal-binding site
1036673011412	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1036673011413	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1036673011414	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1036673011415	putative sugar binding sites [chemical binding]; other site
1036673011416	Q-X-W motif; other site
1036673011417	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1036673011418	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673011419	active site
1036673011420	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673011421	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011422	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1036673011423	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673011424	MarR family; Region: MarR_2; cl17246
1036673011425	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
1036673011426	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1036673011427	Mycobacterium 19 kDa lipoprotein antigen; Region: Myco_19_kDa; pfam05481
1036673011428	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1036673011429	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673011430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011431	dimer interface [polypeptide binding]; other site
1036673011432	conserved gate region; other site
1036673011433	putative PBP binding loops; other site
1036673011434	ABC-ATPase subunit interface; other site
1036673011435	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673011436	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011437	dimer interface [polypeptide binding]; other site
1036673011438	conserved gate region; other site
1036673011439	ABC-ATPase subunit interface; other site
1036673011440	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673011441	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011442	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1036673011443	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673011444	Coenzyme A binding pocket [chemical binding]; other site
1036673011445	DinB superfamily; Region: DinB_2; pfam12867
1036673011446	DinB family; Region: DinB; cl17821
1036673011447	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1036673011448	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673011449	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1036673011450	Coenzyme A binding pocket [chemical binding]; other site
1036673011451	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673011452	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673011453	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1036673011454	active site
1036673011455	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673011456	DinB family; Region: DinB; cl17821
1036673011457	DinB superfamily; Region: DinB_2; pfam12867
1036673011458	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673011459	Coenzyme A binding pocket [chemical binding]; other site
1036673011460	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1036673011461	ligand-binding site [chemical binding]; other site
1036673011462	coproporphyrinogen III oxidase; Validated; Region: PRK08208
1036673011463	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673011464	FeS/SAM binding site; other site
1036673011465	HemN C-terminal domain; Region: HemN_C; pfam06969
1036673011466	Sulfatase; Region: Sulfatase; cl17466
1036673011467	D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181
1036673011468	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
1036673011469	Substrate binding site [chemical binding]; other site
1036673011470	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1036673011471	putative hydrophobic ligand binding site [chemical binding]; other site
1036673011472	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1036673011473	Carboxylesterase family; Region: COesterase; pfam00135
1036673011474	substrate binding pocket [chemical binding]; other site
1036673011475	catalytic triad [active]
1036673011476	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673011477	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673011478	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
1036673011479	Walker A/P-loop; other site
1036673011480	ATP binding site [chemical binding]; other site
1036673011481	Q-loop/lid; other site
1036673011482	ABC transporter signature motif; other site
1036673011483	Walker B; other site
1036673011484	D-loop; other site
1036673011485	H-loop/switch region; other site
1036673011486	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673011487	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673011488	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673011489	Walker A/P-loop; other site
1036673011490	ATP binding site [chemical binding]; other site
1036673011491	Q-loop/lid; other site
1036673011492	ABC transporter signature motif; other site
1036673011493	Walker B; other site
1036673011494	D-loop; other site
1036673011495	H-loop/switch region; other site
1036673011496	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673011497	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673011498	dipeptidase PepV; Reviewed; Region: PRK07318
1036673011499	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1036673011500	active site
1036673011501	metal binding site [ion binding]; metal-binding site
1036673011502	Ankyrin repeats (many copies); Region: Ank_4; pfam13637
1036673011503	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036673011504	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1036673011505	SnoaL-like domain; Region: SnoaL_2; pfam12680
1036673011506	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795
1036673011507	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673011508	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673011509	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1036673011510	Predicted transcriptional regulator [Transcription]; Region: COG2378
1036673011511	HTH domain; Region: HTH_11; pfam08279
1036673011512	WYL domain; Region: WYL; pfam13280
1036673011513	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1036673011514	dimer interface [polypeptide binding]; other site
1036673011515	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673011516	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673011517	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673011518	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
1036673011519	putative dimerization interface [polypeptide binding]; other site
1036673011520	OsmC-like protein; Region: OsmC; pfam02566
1036673011521	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1036673011522	substrate binding site [chemical binding]; other site
1036673011523	THF binding site; other site
1036673011524	zinc-binding site [ion binding]; other site
1036673011525	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1036673011526	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673011527	substrate binding pocket [chemical binding]; other site
1036673011528	membrane-bound complex binding site; other site
1036673011529	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1036673011530	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1036673011531	active site
1036673011532	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673011533	NAD(P) binding site [chemical binding]; other site
1036673011534	active site
1036673011535	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673011536	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673011537	DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005
1036673011538	Ca binding site [ion binding]; other site
1036673011539	carbohydrate binding site [chemical binding]; other site
1036673011540	Putative esterase; Region: Esterase; pfam00756
1036673011541	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673011542	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673011543	active site
1036673011544	phosphorylation site [posttranslational modification]
1036673011545	intermolecular recognition site; other site
1036673011546	dimerization interface [polypeptide binding]; other site
1036673011547	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673011548	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011549	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011550	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673011551	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673011552	dimerization interface [polypeptide binding]; other site
1036673011553	Histidine kinase; Region: His_kinase; pfam06580
1036673011554	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673011555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011556	dimer interface [polypeptide binding]; other site
1036673011557	conserved gate region; other site
1036673011558	putative PBP binding loops; other site
1036673011559	ABC-ATPase subunit interface; other site
1036673011560	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673011561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011562	dimer interface [polypeptide binding]; other site
1036673011563	conserved gate region; other site
1036673011564	ABC-ATPase subunit interface; other site
1036673011565	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673011566	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1036673011567	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
1036673011568	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
1036673011569	putative ligand binding site [chemical binding]; other site
1036673011570	DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005
1036673011571	Ca binding site [ion binding]; other site
1036673011572	carbohydrate binding site [chemical binding]; other site
1036673011573	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673011574	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011575	dimer interface [polypeptide binding]; other site
1036673011576	conserved gate region; other site
1036673011577	ABC-ATPase subunit interface; other site
1036673011578	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673011579	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011580	dimer interface [polypeptide binding]; other site
1036673011581	conserved gate region; other site
1036673011582	ABC-ATPase subunit interface; other site
1036673011583	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673011584	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673011585	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673011586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673011587	active site
1036673011588	phosphorylation site [posttranslational modification]
1036673011589	intermolecular recognition site; other site
1036673011590	dimerization interface [polypeptide binding]; other site
1036673011591	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673011592	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673011593	HAMP domain; Region: HAMP; pfam00672
1036673011594	Histidine kinase; Region: His_kinase; pfam06580
1036673011595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673011596	ATP binding site [chemical binding]; other site
1036673011597	Mg2+ binding site [ion binding]; other site
1036673011598	G-X-G motif; other site
1036673011599	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673011600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673011601	active site
1036673011602	phosphorylation site [posttranslational modification]
1036673011603	intermolecular recognition site; other site
1036673011604	dimerization interface [polypeptide binding]; other site
1036673011605	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673011606	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011607	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011608	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673011609	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673011610	active site
1036673011611	phosphorylation site [posttranslational modification]
1036673011612	intermolecular recognition site; other site
1036673011613	dimerization interface [polypeptide binding]; other site
1036673011614	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673011615	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011616	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011617	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673011618	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673011619	dimerization interface [polypeptide binding]; other site
1036673011620	Histidine kinase; Region: His_kinase; pfam06580
1036673011621	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673011622	ATP binding site [chemical binding]; other site
1036673011623	Mg2+ binding site [ion binding]; other site
1036673011624	G-X-G motif; other site
1036673011625	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673011626	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673011627	Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003
1036673011628	substrate binding site [chemical binding]; other site
1036673011629	active site
1036673011630	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
1036673011631	metal binding site [ion binding]; metal-binding site
1036673011632	ligand binding site [chemical binding]; other site
1036673011633	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1036673011634	metal binding site [ion binding]; metal-binding site
1036673011635	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011636	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673011637	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036673011638	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673011639	S-adenosylmethionine binding site [chemical binding]; other site
1036673011640	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673011641	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673011642	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673011643	acyl-activating enzyme (AAE) consensus motif; other site
1036673011644	acyl-activating enzyme (AAE) consensus motif; other site
1036673011645	AMP binding site [chemical binding]; other site
1036673011646	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011647	Condensation domain; Region: Condensation; pfam00668
1036673011648	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011649	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1036673011650	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673011651	acyl-activating enzyme (AAE) consensus motif; other site
1036673011652	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1036673011653	putative FMN binding site [chemical binding]; other site
1036673011654	NADPH bind site [chemical binding]; other site
1036673011655	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1036673011656	AMP binding site [chemical binding]; other site
1036673011657	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011658	Thioesterase domain; Region: Thioesterase; pfam00975
1036673011659	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
1036673011660	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
1036673011661	active site
1036673011662	catalytic residues [active]
1036673011663	metal binding site [ion binding]; metal-binding site
1036673011664	DmpG-like communication domain; Region: DmpG_comm; pfam07836
1036673011665	acetaldehyde dehydrogenase; Validated; Region: PRK08300
1036673011666	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1036673011667	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
1036673011668	acyl-CoA synthetase; Validated; Region: PRK09192
1036673011669	The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908
1036673011670	acyl-activating enzyme (AAE) consensus motif; other site
1036673011671	putative AMP binding site [chemical binding]; other site
1036673011672	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011673	Condensation domain; Region: Condensation; pfam00668
1036673011674	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011675	Nonribosomal peptide synthase; Region: NRPS; pfam08415
1036673011676	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1036673011677	acyl-activating enzyme (AAE) consensus motif; other site
1036673011678	AMP binding site [chemical binding]; other site
1036673011679	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011680	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1036673011681	putative FMN binding site [chemical binding]; other site
1036673011682	NADPH bind site [chemical binding]; other site
1036673011683	Condensation domain; Region: Condensation; pfam00668
1036673011684	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011685	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673011686	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
1036673011687	Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545
1036673011688	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673011689	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1036673011690	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011691	dimer interface [polypeptide binding]; other site
1036673011692	conserved gate region; other site
1036673011693	putative PBP binding loops; other site
1036673011694	ABC-ATPase subunit interface; other site
1036673011695	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011696	dimer interface [polypeptide binding]; other site
1036673011697	conserved gate region; other site
1036673011698	putative PBP binding loops; other site
1036673011699	ABC-ATPase subunit interface; other site
1036673011700	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1036673011701	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673011702	Walker A/P-loop; other site
1036673011703	ATP binding site [chemical binding]; other site
1036673011704	Q-loop/lid; other site
1036673011705	ABC transporter signature motif; other site
1036673011706	Walker B; other site
1036673011707	D-loop; other site
1036673011708	H-loop/switch region; other site
1036673011709	TOBE domain; Region: TOBE_2; pfam08402
1036673011710	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1036673011711	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1036673011712	putative hydrolase; Provisional; Region: PRK02113
1036673011713	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1036673011714	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1036673011715	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1036673011716	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673011717	DNA-binding site [nucleotide binding]; DNA binding site
1036673011718	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673011719	Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532
1036673011720	ligand binding site [chemical binding]; other site
1036673011721	dimerization interface [polypeptide binding]; other site
1036673011722	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673011723	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673011724	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1036673011725	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1036673011726	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673011727	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673011728	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673011729	active site
1036673011730	phosphorylation site [posttranslational modification]
1036673011731	intermolecular recognition site; other site
1036673011732	dimerization interface [polypeptide binding]; other site
1036673011733	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673011734	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011735	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011736	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673011737	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673011738	dimerization interface [polypeptide binding]; other site
1036673011739	Histidine kinase; Region: His_kinase; pfam06580
1036673011740	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673011741	ATP binding site [chemical binding]; other site
1036673011742	Mg2+ binding site [ion binding]; other site
1036673011743	G-X-G motif; other site
1036673011744	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673011745	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1036673011746	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1036673011747	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
1036673011748	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673011749	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011750	dimer interface [polypeptide binding]; other site
1036673011751	conserved gate region; other site
1036673011752	putative PBP binding loops; other site
1036673011753	ABC-ATPase subunit interface; other site
1036673011754	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1036673011755	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011756	dimer interface [polypeptide binding]; other site
1036673011757	conserved gate region; other site
1036673011758	putative PBP binding loops; other site
1036673011759	ABC-ATPase subunit interface; other site
1036673011760	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673011761	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1036673011762	S-layer homology domain; Region: SLH; pfam00395
1036673011763	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1036673011764	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1036673011765	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1036673011766	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1036673011767	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1036673011768	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1036673011769	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1036673011770	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1036673011771	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673011772	putative active site [active]
1036673011773	putative metal binding site [ion binding]; other site
1036673011774	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1036673011775	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673011776	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1036673011777	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673011778	NAD(P) binding site [chemical binding]; other site
1036673011779	active site
1036673011780	Predicted membrane protein [Function unknown]; Region: COG3428
1036673011781	Bacterial PH domain; Region: DUF304; pfam03703
1036673011782	Bacterial PH domain; Region: DUF304; pfam03703
1036673011783	Uncharacterized conserved protein [Function unknown]; Region: COG3402
1036673011784	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1036673011785	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673011786	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011787	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673011788	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673011789	putative substrate translocation pore; other site
1036673011790	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673011791	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
1036673011792	Putative Ig domain; Region: He_PIG; pfam05345
1036673011793	S-layer homology domain; Region: SLH; pfam00395
1036673011794	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673011795	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673011796	short chain dehydrogenase; Provisional; Region: PRK06924
1036673011797	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673011798	NAD(P) binding site [chemical binding]; other site
1036673011799	active site
1036673011800	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1036673011801	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1036673011802	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673011803	NAD(P) binding site [chemical binding]; other site
1036673011804	active site
1036673011805	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1036673011806	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1036673011807	Protein of unknown function (DUF4085); Region: DUF4085; pfam13315
1036673011808	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
1036673011809	dimer interface [polypeptide binding]; other site
1036673011810	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673011811	ligand binding site [chemical binding]; other site
1036673011812	Cupin domain; Region: Cupin_2; pfam07883
1036673011813	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673011814	MarR family; Region: MarR; pfam01047
1036673011815	hypothetical protein; Provisional; Region: PRK08244
1036673011816	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1036673011817	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
1036673011818	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1036673011819	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1036673011820	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1036673011821	inhibitor binding site; inhibition site
1036673011822	active site
1036673011823	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673011824	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673011825	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1036673011826	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673011827	putative DNA binding site [nucleotide binding]; other site
1036673011828	putative Zn2+ binding site [ion binding]; other site
1036673011829	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673011830	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673011831	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
1036673011832	putative dimer interface [polypeptide binding]; other site
1036673011833	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673011834	phosphoenolpyruvate synthase; Validated; Region: PRK06241
1036673011835	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1036673011836	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1036673011837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673011838	putative substrate translocation pore; other site
1036673011839	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673011840	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673011841	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673011842	dimerization interface [polypeptide binding]; other site
1036673011843	putative DNA binding site [nucleotide binding]; other site
1036673011844	putative Zn2+ binding site [ion binding]; other site
1036673011845	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
1036673011846	short chain dehydrogenase; Provisional; Region: PRK08263
1036673011847	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1036673011848	NADP binding site [chemical binding]; other site
1036673011849	active site
1036673011850	steroid binding site; other site
1036673011851	Pectate lyase; Region: Pec_lyase_C; cl01593
1036673011852	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
1036673011853	metal binding site [ion binding]; metal-binding site
1036673011854	ligand binding site [chemical binding]; other site
1036673011855	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673011856	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673011857	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011858	glutamate dehydrogenase; Provisional; Region: PRK09414
1036673011859	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1036673011860	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1036673011861	NAD(P) binding site [chemical binding]; other site
1036673011862	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673011863	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673011864	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1036673011865	putative dimerization interface [polypeptide binding]; other site
1036673011866	Creatinine amidohydrolase; Region: Creatininase; pfam02633
1036673011867	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673011868	active site
1036673011869	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673011870	catalytic tetrad [active]
1036673011871	Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528
1036673011872	[2Fe-2S] cluster binding site [ion binding]; other site
1036673011873	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1036673011874	This CD includes the putative hydrocarbon oxygenase, MocD, a bacterial rhizopine (3-O-methyl-scyllo-inosamine, 3-O-MSI) oxygenase, and other related proteins. It has been proposed that MocD, MocE (Rieske-like ferredoxin), and MocF (ferredoxin reductase)...; Region: Rhizopine-oxygenase-like; cd03511
1036673011875	putative di-iron ligands [ion binding]; other site
1036673011876	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1036673011877	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1036673011878	AP (apurinic/apyrimidinic) site pocket; other site
1036673011879	DNA interaction; other site
1036673011880	Metal-binding active site; metal-binding site
1036673011881	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673011882	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673011883	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673011884	aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081
1036673011885	active site
1036673011886	catalytic residues [active]
1036673011887	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1036673011888	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1036673011889	inhibitor binding site; inhibition site
1036673011890	active site
1036673011891	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673011892	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673011893	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673011894	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011895	dimer interface [polypeptide binding]; other site
1036673011896	conserved gate region; other site
1036673011897	putative PBP binding loops; other site
1036673011898	ABC-ATPase subunit interface; other site
1036673011899	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673011900	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
1036673011901	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1036673011902	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673011903	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673011904	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673011905	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673011906	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673011907	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1036673011908	active site 2 [active]
1036673011909	active site 1 [active]
1036673011910	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1036673011911	Amidohydrolase; Region: Amidohydro_2; pfam04909
1036673011912	active site
1036673011913	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1036673011914	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1036673011915	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1036673011916	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673011917	DNA-binding site [nucleotide binding]; DNA binding site
1036673011918	FCD domain; Region: FCD; pfam07729
1036673011919	Uncharacterized protein conserved in bacteria (DUF2251); Region: DUF2251; cl01770
1036673011920	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1036673011921	EamA-like transporter family; Region: EamA; pfam00892
1036673011922	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
1036673011923	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673011924	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673011925	putative DNA binding site [nucleotide binding]; other site
1036673011926	putative Zn2+ binding site [ion binding]; other site
1036673011927	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1036673011928	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673011929	salt bridge; other site
1036673011930	non-specific DNA binding site [nucleotide binding]; other site
1036673011931	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1036673011932	sequence-specific DNA binding site [nucleotide binding]; other site
1036673011933	PAS domain; Region: PAS; smart00091
1036673011934	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
1036673011935	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1036673011936	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
1036673011937	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673011938	motif II; other site
1036673011939	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
1036673011940	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1036673011941	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673011942	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011943	dimer interface [polypeptide binding]; other site
1036673011944	conserved gate region; other site
1036673011945	putative PBP binding loops; other site
1036673011946	ABC-ATPase subunit interface; other site
1036673011947	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673011948	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673011949	dimer interface [polypeptide binding]; other site
1036673011950	conserved gate region; other site
1036673011951	putative PBP binding loops; other site
1036673011952	ABC-ATPase subunit interface; other site
1036673011953	maltodextrin glucosidase; Provisional; Region: PRK10785
1036673011954	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1036673011955	homodimer interface [polypeptide binding]; other site
1036673011956	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1036673011957	active site
1036673011958	homodimer interface [polypeptide binding]; other site
1036673011959	catalytic site [active]
1036673011960	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1036673011961	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1036673011962	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1036673011963	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673011964	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673011965	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673011966	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673011967	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
1036673011968	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1036673011969	active site
1036673011970	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1036673011971	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1036673011972	dimer interface [polypeptide binding]; other site
1036673011973	active site
1036673011974	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011975	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1036673011976	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1036673011977	NAD(P) binding site [chemical binding]; other site
1036673011978	homotetramer interface [polypeptide binding]; other site
1036673011979	homodimer interface [polypeptide binding]; other site
1036673011980	active site
1036673011981	Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233
1036673011982	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1036673011983	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1036673011984	Methylamine utilisation protein MauE; Region: MauE; pfam07291
1036673011985	Condensation domain; Region: Condensation; pfam00668
1036673011986	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011987	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673011988	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673011989	acyl-activating enzyme (AAE) consensus motif; other site
1036673011990	AMP binding site [chemical binding]; other site
1036673011991	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011992	Condensation domain; Region: Condensation; pfam00668
1036673011993	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673011994	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673011995	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1036673011996	acyl-activating enzyme (AAE) consensus motif; other site
1036673011997	AMP binding site [chemical binding]; other site
1036673011998	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673011999	Condensation domain; Region: Condensation; pfam00668
1036673012000	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673012001	Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321
1036673012002	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1036673012003	active site
1036673012004	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1036673012005	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1036673012006	beta-ketoacyl reductase (KR) domain of fatty acid synthase (FAS), subgroup 2, complex (x); Region: KR_2_FAS_SDR_x; cd08955
1036673012007	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1036673012008	putative NADP binding site [chemical binding]; other site
1036673012009	active site
1036673012010	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1036673012011	Thioesterase domain; Region: Thioesterase; pfam00975
1036673012012	peptide synthase; Provisional; Region: PRK12467
1036673012013	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012014	acyl-activating enzyme (AAE) consensus motif; other site
1036673012015	AMP binding site [chemical binding]; other site
1036673012016	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012017	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012018	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012019	acyl-activating enzyme (AAE) consensus motif; other site
1036673012020	AMP binding site [chemical binding]; other site
1036673012021	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012022	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673012023	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673012024	acyl-activating enzyme (AAE) consensus motif; other site
1036673012025	AMP binding site [chemical binding]; other site
1036673012026	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012027	Condensation domain; Region: Condensation; pfam00668
1036673012028	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673012029	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1036673012030	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1036673012031	acyl-activating enzyme (AAE) consensus motif; other site
1036673012032	AMP binding site [chemical binding]; other site
1036673012033	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012034	Condensation domain; Region: Condensation; pfam00668
1036673012035	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012036	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012037	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012038	acyl-activating enzyme (AAE) consensus motif; other site
1036673012039	AMP binding site [chemical binding]; other site
1036673012040	Condensation domain; Region: Condensation; pfam00668
1036673012041	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012042	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012043	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012044	acyl-activating enzyme (AAE) consensus motif; other site
1036673012045	AMP binding site [chemical binding]; other site
1036673012046	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012047	Condensation domain; Region: Condensation; pfam00668
1036673012048	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012049	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012050	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673012051	acyl-activating enzyme (AAE) consensus motif; other site
1036673012052	AMP binding site [chemical binding]; other site
1036673012053	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012054	Condensation domain; Region: Condensation; pfam00668
1036673012055	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012056	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673012057	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07768
1036673012058	The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908
1036673012059	acyl-activating enzyme (AAE) consensus motif; other site
1036673012060	putative AMP binding site [chemical binding]; other site
1036673012061	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012062	Condensation domain; Region: Condensation; pfam00668
1036673012063	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012064	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012065	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1036673012066	acyl-activating enzyme (AAE) consensus motif; other site
1036673012067	AMP binding site [chemical binding]; other site
1036673012068	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012069	Condensation domain; Region: Condensation; pfam00668
1036673012070	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673012071	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1036673012072	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673012073	H+ Antiporter protein; Region: 2A0121; TIGR00900
1036673012074	putative substrate translocation pore; other site
1036673012075	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673012076	DNA binding residues [nucleotide binding]
1036673012077	Condensation domain; Region: Condensation; pfam00668
1036673012078	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012079	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673012080	acyl-activating enzyme (AAE) consensus motif; other site
1036673012081	AMP binding site [chemical binding]; other site
1036673012082	active site
1036673012083	CoA binding site [chemical binding]; other site
1036673012084	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012085	Condensation domain; Region: Condensation; pfam00668
1036673012086	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012087	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1036673012088	acyl-activating enzyme (AAE) consensus motif; other site
1036673012089	AMP binding site [chemical binding]; other site
1036673012090	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012091	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1036673012092	Condensation domain; Region: Condensation; pfam00668
1036673012093	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012094	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012095	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012096	acyl-activating enzyme (AAE) consensus motif; other site
1036673012097	AMP binding site [chemical binding]; other site
1036673012098	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012099	Condensation domain; Region: Condensation; pfam00668
1036673012100	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012101	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1036673012102	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673012103	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012104	acyl-activating enzyme (AAE) consensus motif; other site
1036673012105	AMP binding site [chemical binding]; other site
1036673012106	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012107	Condensation domain; Region: Condensation; pfam00668
1036673012108	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012109	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012110	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012111	acyl-activating enzyme (AAE) consensus motif; other site
1036673012112	AMP binding site [chemical binding]; other site
1036673012113	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012114	Condensation domain; Region: Condensation; pfam00668
1036673012115	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012116	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012117	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012118	acyl-activating enzyme (AAE) consensus motif; other site
1036673012119	AMP binding site [chemical binding]; other site
1036673012120	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012121	Condensation domain; Region: Condensation; pfam00668
1036673012122	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012123	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012124	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012125	acyl-activating enzyme (AAE) consensus motif; other site
1036673012126	AMP binding site [chemical binding]; other site
1036673012127	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012128	Condensation domain; Region: Condensation; pfam00668
1036673012129	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673012130	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673012131	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673012132	acyl-activating enzyme (AAE) consensus motif; other site
1036673012133	AMP binding site [chemical binding]; other site
1036673012134	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012135	Condensation domain; Region: Condensation; pfam00668
1036673012136	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012137	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012138	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673012139	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036673012140	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673012141	S-adenosylmethionine binding site [chemical binding]; other site
1036673012142	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012143	acyl-activating enzyme (AAE) consensus motif; other site
1036673012144	AMP binding site [chemical binding]; other site
1036673012145	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012146	Condensation domain; Region: Condensation; pfam00668
1036673012147	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673012148	Condensation domain; Region: Condensation; pfam00668
1036673012149	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012150	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1036673012151	acyl-activating enzyme (AAE) consensus motif; other site
1036673012152	AMP binding site [chemical binding]; other site
1036673012153	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012154	Thioesterase domain; Region: Thioesterase; pfam00975
1036673012155	Condensation domain; Region: Condensation; pfam00668
1036673012156	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673012157	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673012158	acyl-activating enzyme (AAE) consensus motif; other site
1036673012159	AMP binding site [chemical binding]; other site
1036673012160	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012161	Condensation domain; Region: Condensation; pfam00668
1036673012162	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012163	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012164	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673012165	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1036673012166	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673012167	S-adenosylmethionine binding site [chemical binding]; other site
1036673012168	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673012169	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673012170	acyl-activating enzyme (AAE) consensus motif; other site
1036673012171	AMP binding site [chemical binding]; other site
1036673012172	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012173	Condensation domain; Region: Condensation; pfam00668
1036673012174	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012175	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012176	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673012177	acyl-activating enzyme (AAE) consensus motif; other site
1036673012178	AMP binding site [chemical binding]; other site
1036673012179	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012180	Condensation domain; Region: Condensation; pfam00668
1036673012181	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012182	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012183	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1036673012184	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1036673012185	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1036673012186	trimer interface [polypeptide binding]; other site
1036673012187	active site
1036673012188	substrate binding site [chemical binding]; other site
1036673012189	CoA binding site [chemical binding]; other site
1036673012190	Glycosyl hydrolase family 59; Region: Glyco_hydro_59; pfam02057
1036673012191	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1036673012192	TrkA-N domain; Region: TrkA_N; pfam02254
1036673012193	TrkA-C domain; Region: TrkA_C; pfam02080
1036673012194	OsmC-like protein; Region: OsmC; pfam02566
1036673012195	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673012196	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1036673012197	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673012198	Ferredoxin [Energy production and conversion]; Region: COG1146
1036673012199	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1036673012200	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
1036673012201	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673012202	Nitroreductase-like family 2. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_2; cd02138
1036673012203	putative FMN binding site [chemical binding]; other site
1036673012204	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673012205	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1036673012206	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1036673012207	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1036673012208	active site
1036673012209	non-prolyl cis peptide bond; other site
1036673012210	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1036673012211	dimer interface [polypeptide binding]; other site
1036673012212	FMN binding site [chemical binding]; other site
1036673012213	NADPH bind site [chemical binding]; other site
1036673012214	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1036673012215	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1036673012216	active site
1036673012217	non-prolyl cis peptide bond; other site
1036673012218	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673012219	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673012220	active site
1036673012221	catalytic tetrad [active]
1036673012222	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673012223	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1036673012224	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1036673012225	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1036673012226	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1036673012227	active site
1036673012228	non-prolyl cis peptide bond; other site
1036673012229	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1036673012230	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1036673012231	active site
1036673012232	non-prolyl cis peptide bond; other site
1036673012233	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1036673012234	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1036673012235	active site
1036673012236	non-prolyl cis peptide bond; other site
1036673012237	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673012238	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673012239	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1036673012240	Walker A/P-loop; other site
1036673012241	ATP binding site [chemical binding]; other site
1036673012242	Q-loop/lid; other site
1036673012243	ABC transporter signature motif; other site
1036673012244	Walker B; other site
1036673012245	D-loop; other site
1036673012246	H-loop/switch region; other site
1036673012247	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673012248	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673012249	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673012250	Walker A/P-loop; other site
1036673012251	ATP binding site [chemical binding]; other site
1036673012252	Q-loop/lid; other site
1036673012253	ABC transporter signature motif; other site
1036673012254	Walker B; other site
1036673012255	D-loop; other site
1036673012256	H-loop/switch region; other site
1036673012257	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1036673012258	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012259	dimer interface [polypeptide binding]; other site
1036673012260	conserved gate region; other site
1036673012261	putative PBP binding loops; other site
1036673012262	ABC-ATPase subunit interface; other site
1036673012263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012264	ABC-ATPase subunit interface; other site
1036673012265	putative PBP binding loops; other site
1036673012266	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
1036673012267	NHL repeat; Region: NHL; pfam01436
1036673012268	NHL repeat; Region: NHL; pfam01436
1036673012269	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1036673012270	Yip1 domain; Region: Yip1; cl17815
1036673012271	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673012272	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012273	dimer interface [polypeptide binding]; other site
1036673012274	conserved gate region; other site
1036673012275	putative PBP binding loops; other site
1036673012276	ABC-ATPase subunit interface; other site
1036673012277	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673012278	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012279	dimer interface [polypeptide binding]; other site
1036673012280	conserved gate region; other site
1036673012281	putative PBP binding loops; other site
1036673012282	ABC-ATPase subunit interface; other site
1036673012283	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1036673012284	putative metal binding site [ion binding]; other site
1036673012285	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1036673012286	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673012287	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673012288	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1036673012289	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1036673012290	Walker A/P-loop; other site
1036673012291	ATP binding site [chemical binding]; other site
1036673012292	Q-loop/lid; other site
1036673012293	ABC transporter signature motif; other site
1036673012294	Walker B; other site
1036673012295	D-loop; other site
1036673012296	H-loop/switch region; other site
1036673012297	TOBE domain; Region: TOBE_2; pfam08402
1036673012298	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1036673012299	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1036673012300	Cysteine-rich domain; Region: CCG; pfam02754
1036673012301	Cysteine-rich domain; Region: CCG; pfam02754
1036673012302	FAD binding domain; Region: FAD_binding_4; pfam01565
1036673012303	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
1036673012304	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673012305	salt bridge; other site
1036673012306	non-specific DNA binding site [nucleotide binding]; other site
1036673012307	sequence-specific DNA binding site [nucleotide binding]; other site
1036673012308	Protein of unknown function (DUF3036); Region: DUF3036; pfam11234
1036673012309	Predicted membrane protein [Function unknown]; Region: COG2311
1036673012310	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1036673012311	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1036673012312	putative catalytic site [active]
1036673012313	putative metal binding site [ion binding]; other site
1036673012314	putative phosphate binding site [ion binding]; other site
1036673012315	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1036673012316	dimer interface [polypeptide binding]; other site
1036673012317	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673012318	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1036673012319	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1036673012320	putative NAD(P) binding site [chemical binding]; other site
1036673012321	dimer interface [polypeptide binding]; other site
1036673012322	Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988
1036673012323	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673012324	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673012325	putative substrate translocation pore; other site
1036673012326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673012327	Helix-turn-helix domain; Region: HTH_31; pfam13560
1036673012328	salt bridge; other site
1036673012329	non-specific DNA binding site [nucleotide binding]; other site
1036673012330	sequence-specific DNA binding site [nucleotide binding]; other site
1036673012331	Transposase domain (DUF772); Region: DUF772; pfam05598
1036673012332	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1036673012333	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1036673012334	DinB family; Region: DinB; cl17821
1036673012335	DinB superfamily; Region: DinB_2; pfam12867
1036673012336	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673012337	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673012338	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1036673012339	dimerization interface [polypeptide binding]; other site
1036673012340	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673012341	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673012342	putative substrate translocation pore; other site
1036673012343	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673012344	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673012345	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673012346	MarR family; Region: MarR_2; pfam12802
1036673012347	RibD C-terminal domain; Region: RibD_C; cl17279
1036673012348	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673012349	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1036673012350	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673012351	putative DNA binding site [nucleotide binding]; other site
1036673012352	putative Zn2+ binding site [ion binding]; other site
1036673012353	AsnC family; Region: AsnC_trans_reg; pfam01037
1036673012354	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1036673012355	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283
1036673012356	putative NAD(P) binding site [chemical binding]; other site
1036673012357	putative substrate binding site [chemical binding]; other site
1036673012358	catalytic Zn binding site [ion binding]; other site
1036673012359	structural Zn binding site [ion binding]; other site
1036673012360	dimer interface [polypeptide binding]; other site
1036673012361	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1036673012362	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1036673012363	dimer interface [polypeptide binding]; other site
1036673012364	PYR/PP interface [polypeptide binding]; other site
1036673012365	TPP binding site [chemical binding]; other site
1036673012366	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1036673012367	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1036673012368	TPP-binding site [chemical binding]; other site
1036673012369	dimer interface [polypeptide binding]; other site
1036673012370	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1036673012371	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1036673012372	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673012373	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673012374	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673012375	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1036673012376	dimerization interface [polypeptide binding]; other site
1036673012377	Histidine kinase; Region: His_kinase; pfam06580
1036673012378	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673012379	ATP binding site [chemical binding]; other site
1036673012380	Mg2+ binding site [ion binding]; other site
1036673012381	G-X-G motif; other site
1036673012382	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673012383	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673012384	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012385	dimer interface [polypeptide binding]; other site
1036673012386	conserved gate region; other site
1036673012387	putative PBP binding loops; other site
1036673012388	ABC-ATPase subunit interface; other site
1036673012389	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673012390	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012391	dimer interface [polypeptide binding]; other site
1036673012392	conserved gate region; other site
1036673012393	ABC-ATPase subunit interface; other site
1036673012394	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1036673012395	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673012396	active site
1036673012397	phosphorylation site [posttranslational modification]
1036673012398	intermolecular recognition site; other site
1036673012399	dimerization interface [polypeptide binding]; other site
1036673012400	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673012401	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1036673012402	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673012403	DNA-binding site [nucleotide binding]; DNA binding site
1036673012404	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673012405	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673012406	homodimer interface [polypeptide binding]; other site
1036673012407	catalytic residue [active]
1036673012408	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1036673012409	dimer interface [polypeptide binding]; other site
1036673012410	FMN binding site [chemical binding]; other site
1036673012411	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1036673012412	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1036673012413	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1036673012414	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1036673012415	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1036673012416	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
1036673012417	DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005
1036673012418	Ca binding site [ion binding]; other site
1036673012419	carbohydrate binding site [chemical binding]; other site
1036673012420	S-layer homology domain; Region: SLH; pfam00395
1036673012421	S-layer homology domain; Region: SLH; pfam00395
1036673012422	S-layer homology domain; Region: SLH; pfam00395
1036673012423	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1036673012424	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1036673012425	NAD(P) binding site [chemical binding]; other site
1036673012426	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673012427	sequence-specific DNA binding site [nucleotide binding]; other site
1036673012428	salt bridge; other site
1036673012429	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673012430	S-adenosylmethionine binding site [chemical binding]; other site
1036673012431	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
1036673012432	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1036673012433	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673012434	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673012435	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1036673012436	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036673012437	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673012438	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673012439	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673012440	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673012441	metal binding site [ion binding]; metal-binding site
1036673012442	active site
1036673012443	I-site; other site
1036673012444	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1036673012445	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673012446	dimerization interface [polypeptide binding]; other site
1036673012447	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673012448	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673012449	dimer interface [polypeptide binding]; other site
1036673012450	putative CheW interface [polypeptide binding]; other site
1036673012451	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1036673012452	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673012453	dimerization interface [polypeptide binding]; other site
1036673012454	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673012455	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673012456	metal binding site [ion binding]; metal-binding site
1036673012457	active site
1036673012458	I-site; other site
1036673012459	Cache domain; Region: Cache_1; pfam02743
1036673012460	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1036673012461	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673012462	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673012463	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673012464	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1036673012465	Condensation domain; Region: Condensation; pfam00668
1036673012466	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012467	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012468	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012469	acyl-activating enzyme (AAE) consensus motif; other site
1036673012470	AMP binding site [chemical binding]; other site
1036673012471	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012472	Condensation domain; Region: Condensation; pfam00668
1036673012473	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012474	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1036673012475	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1036673012476	active site
1036673012477	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012478	Condensation domain; Region: Condensation; pfam00668
1036673012479	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012480	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673012481	acyl-activating enzyme (AAE) consensus motif; other site
1036673012482	AMP binding site [chemical binding]; other site
1036673012483	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012484	Condensation domain; Region: Condensation; pfam00668
1036673012485	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012486	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012487	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012488	acyl-activating enzyme (AAE) consensus motif; other site
1036673012489	AMP binding site [chemical binding]; other site
1036673012490	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012491	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
1036673012492	conserved cys residue [active]
1036673012493	Putative amidotransferase; Region: DUF4066; pfam13278
1036673012494	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1036673012495	Predicted transcriptional regulators [Transcription]; Region: COG1695
1036673012496	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1036673012497	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673012498	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673012499	acyl-activating enzyme (AAE) consensus motif; other site
1036673012500	AMP binding site [chemical binding]; other site
1036673012501	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012502	Condensation domain; Region: Condensation; pfam00668
1036673012503	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012504	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012505	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673012506	acyl-activating enzyme (AAE) consensus motif; other site
1036673012507	AMP binding site [chemical binding]; other site
1036673012508	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012509	Condensation domain; Region: Condensation; pfam00668
1036673012510	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012511	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012512	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012513	acyl-activating enzyme (AAE) consensus motif; other site
1036673012514	AMP binding site [chemical binding]; other site
1036673012515	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012516	Condensation domain; Region: Condensation; pfam00668
1036673012517	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012518	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012519	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012520	acyl-activating enzyme (AAE) consensus motif; other site
1036673012521	AMP binding site [chemical binding]; other site
1036673012522	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012523	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1036673012524	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012525	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012526	acyl-activating enzyme (AAE) consensus motif; other site
1036673012527	AMP binding site [chemical binding]; other site
1036673012528	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012529	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1036673012530	Condensation domain; Region: Condensation; pfam00668
1036673012531	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012532	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673012533	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012534	acyl-activating enzyme (AAE) consensus motif; other site
1036673012535	AMP binding site [chemical binding]; other site
1036673012536	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012537	Condensation domain; Region: Condensation; pfam00668
1036673012538	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012539	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673012540	Condensation domain; Region: Condensation; pfam00668
1036673012541	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012542	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673012543	acyl-activating enzyme (AAE) consensus motif; other site
1036673012544	AMP binding site [chemical binding]; other site
1036673012545	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673012546	Condensation domain; Region: Condensation; pfam00668
1036673012547	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673012548	Condensation domain; Region: Condensation; pfam00668
1036673012549	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673012550	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
1036673012551	Lipase (class 2); Region: Lipase_2; pfam01674
1036673012552	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673012553	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673012554	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1036673012555	NAD(P) binding site [chemical binding]; other site
1036673012556	active site
1036673012557	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1036673012558	active site
1036673012559	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
1036673012560	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
1036673012561	phosphonate ABC transporter, ATP-binding protein; Region: ABC_phnC; TIGR02315
1036673012562	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1036673012563	Walker A/P-loop; other site
1036673012564	ATP binding site [chemical binding]; other site
1036673012565	Q-loop/lid; other site
1036673012566	ABC transporter signature motif; other site
1036673012567	Walker B; other site
1036673012568	D-loop; other site
1036673012569	H-loop/switch region; other site
1036673012570	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1036673012571	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1036673012572	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012573	dimer interface [polypeptide binding]; other site
1036673012574	conserved gate region; other site
1036673012575	ABC-ATPase subunit interface; other site
1036673012576	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1036673012577	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673012578	substrate binding pocket [chemical binding]; other site
1036673012579	membrane-bound complex binding site; other site
1036673012580	hinge residues; other site
1036673012581	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673012582	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1036673012583	DNA-binding site [nucleotide binding]; DNA binding site
1036673012584	FCD domain; Region: FCD; pfam07729
1036673012585	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673012586	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1036673012587	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1036673012588	EamA-like transporter family; Region: EamA; pfam00892
1036673012589	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673012590	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673012591	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673012592	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673012593	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673012594	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012595	dimer interface [polypeptide binding]; other site
1036673012596	conserved gate region; other site
1036673012597	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673012598	ABC-ATPase subunit interface; other site
1036673012599	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673012600	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012601	ABC-ATPase subunit interface; other site
1036673012602	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673012603	Interdomain contacts; other site
1036673012604	Cytokine receptor motif; other site
1036673012605	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673012606	Interdomain contacts; other site
1036673012607	Cytokine receptor motif; other site
1036673012608	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673012609	Interdomain contacts; other site
1036673012610	Cytokine receptor motif; other site
1036673012611	putative pectinesterase; Region: PLN02432; cl01911
1036673012612	Pectinesterase; Region: Pectinesterase; pfam01095
1036673012613	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1036673012614	active site
1036673012615	catalytic triad [active]
1036673012616	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673012617	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673012618	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673012619	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673012620	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261
1036673012621	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1036673012622	putative NAD(P) binding site [chemical binding]; other site
1036673012623	catalytic Zn binding site [ion binding]; other site
1036673012624	structural Zn binding site [ion binding]; other site
1036673012625	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673012626	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673012627	active site
1036673012628	catalytic tetrad [active]
1036673012629	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673012630	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673012631	DNA binding site [nucleotide binding]
1036673012632	domain linker motif; other site
1036673012633	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673012634	dimerization interface [polypeptide binding]; other site
1036673012635	ligand binding site [chemical binding]; other site
1036673012636	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
1036673012637	classical (c) SDRs; Region: SDR_c; cd05233
1036673012638	NAD(P) binding site [chemical binding]; other site
1036673012639	active site
1036673012640	Cytochrome P450; Region: p450; cl12078
1036673012641	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1036673012642	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673012643	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673012644	Protein of unknown function (DUF1349); Region: DUF1349; cl01397
1036673012645	Major royal jelly protein; Region: MRJP; pfam03022
1036673012646	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
1036673012647	dimer interface [polypeptide binding]; other site
1036673012648	FMN binding site [chemical binding]; other site
1036673012649	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1036673012650	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1036673012651	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1036673012652	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
1036673012653	Cellulose binding domain; Region: CBM_3; pfam00942
1036673012654	endoglucanase; Region: PLN02308
1036673012655	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; pfam00759
1036673012656	Cellulose binding domain; Region: CBM_3; pfam00942
1036673012657	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1036673012658	putative metal binding site [ion binding]; other site
1036673012659	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
1036673012660	Cellulose binding domain; Region: CBM_3; pfam00942
1036673012661	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
1036673012662	substrate binding site [chemical binding]; other site
1036673012663	active site
1036673012664	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1036673012665	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1036673012666	putative sugar binding sites [chemical binding]; other site
1036673012667	Q-X-W motif; other site
1036673012668	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673012669	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673012670	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673012671	dimerization interface [polypeptide binding]; other site
1036673012672	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1036673012673	nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034
1036673012674	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673012675	putative substrate translocation pore; other site
1036673012676	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
1036673012677	active site
1036673012678	catalytic triad [active]
1036673012679	oxyanion hole [active]
1036673012680	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1036673012681	Putative esterase; Region: Esterase; pfam00756
1036673012682	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1036673012683	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673012684	ABC-ATPase subunit  interface; other site
1036673012685	dimer interface [polypeptide binding]; other site
1036673012686	putative PBP binding regions; other site
1036673012687	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1036673012688	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673012689	ABC-ATPase subunit  interface; other site
1036673012690	dimer interface [polypeptide binding]; other site
1036673012691	putative PBP binding regions; other site
1036673012692	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1036673012693	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1036673012694	intersubunit interface [polypeptide binding]; other site
1036673012695	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673012696	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673012697	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1036673012698	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1036673012699	intersubunit interface [polypeptide binding]; other site
1036673012700	potential frameshift: common BLAST hit: gi|308071475|ref|YP_003873080.1| Short-chain type dehydrogenase/reductase
1036673012701	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673012702	active site
1036673012703	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673012704	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
1036673012705	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673012706	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673012707	Amb_all domain; Region: Amb_all; smart00656
1036673012708	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
1036673012709	active site
1036673012710	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
1036673012711	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1036673012712	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1036673012713	phosphate binding site [ion binding]; other site
1036673012714	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673012715	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673012716	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1036673012717	Walker A/P-loop; other site
1036673012718	ATP binding site [chemical binding]; other site
1036673012719	Q-loop/lid; other site
1036673012720	ABC transporter signature motif; other site
1036673012721	Walker B; other site
1036673012722	D-loop; other site
1036673012723	H-loop/switch region; other site
1036673012724	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1036673012725	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673012726	putative substrate translocation pore; other site
1036673012727	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673012728	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673012729	The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434
1036673012730	putative dimerization interface [polypeptide binding]; other site
1036673012731	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1036673012732	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1036673012733	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1036673012734	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1036673012735	active site
1036673012736	non-prolyl cis peptide bond; other site
1036673012737	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673012738	substrate binding pocket [chemical binding]; other site
1036673012739	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1036673012740	membrane-bound complex binding site; other site
1036673012741	hinge residues; other site
1036673012742	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1036673012743	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1036673012744	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673012745	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673012746	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036673012747	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012748	dimer interface [polypeptide binding]; other site
1036673012749	conserved gate region; other site
1036673012750	putative PBP binding loops; other site
1036673012751	ABC-ATPase subunit interface; other site
1036673012752	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673012753	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673012754	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673012755	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012756	dimer interface [polypeptide binding]; other site
1036673012757	conserved gate region; other site
1036673012758	ABC-ATPase subunit interface; other site
1036673012759	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673012760	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012761	dimer interface [polypeptide binding]; other site
1036673012762	conserved gate region; other site
1036673012763	ABC-ATPase subunit interface; other site
1036673012764	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673012765	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673012766	active site
1036673012767	phosphorylation site [posttranslational modification]
1036673012768	intermolecular recognition site; other site
1036673012769	dimerization interface [polypeptide binding]; other site
1036673012770	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673012771	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673012772	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673012773	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673012774	dimerization interface [polypeptide binding]; other site
1036673012775	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673012776	Histidine kinase; Region: His_kinase; pfam06580
1036673012777	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673012778	ATP binding site [chemical binding]; other site
1036673012779	Mg2+ binding site [ion binding]; other site
1036673012780	G-X-G motif; other site
1036673012781	Glycosyl hydrolase catalytic core; Region: Glyco_hydro_cc; pfam11790
1036673012782	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1036673012783	Melibiase; Region: Melibiase; pfam02065
1036673012784	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673012785	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673012786	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673012787	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1036673012788	putative metal binding site [ion binding]; other site
1036673012789	Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156
1036673012790	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1036673012791	hypothetical protein; Validated; Region: PRK00029
1036673012792	Pectate lyase; Region: Pec_lyase_C; cl01593
1036673012793	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1036673012794	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673012795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673012796	putative substrate translocation pore; other site
1036673012797	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1036673012798	FAD binding domain; Region: FAD_binding_4; pfam01565
1036673012799	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673012800	Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901
1036673012801	putative hydrophobic ligand binding site [chemical binding]; other site
1036673012802	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1036673012803	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036673012804	Predicted transcriptional regulator [Transcription]; Region: COG1959
1036673012805	Transcriptional regulator; Region: Rrf2; pfam02082
1036673012806	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673012807	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673012808	dimerization interface [polypeptide binding]; other site
1036673012809	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673012810	dimer interface [polypeptide binding]; other site
1036673012811	phosphorylation site [posttranslational modification]
1036673012812	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673012813	ATP binding site [chemical binding]; other site
1036673012814	Mg2+ binding site [ion binding]; other site
1036673012815	G-X-G motif; other site
1036673012816	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673012817	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673012818	active site
1036673012819	phosphorylation site [posttranslational modification]
1036673012820	intermolecular recognition site; other site
1036673012821	dimerization interface [polypeptide binding]; other site
1036673012822	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673012823	FOG: CBS domain [General function prediction only]; Region: COG0517
1036673012824	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636
1036673012825	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673012826	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673012827	active site
1036673012828	phosphorylation site [posttranslational modification]
1036673012829	intermolecular recognition site; other site
1036673012830	dimerization interface [polypeptide binding]; other site
1036673012831	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673012832	DNA binding site [nucleotide binding]
1036673012833	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673012834	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673012835	dimerization interface [polypeptide binding]; other site
1036673012836	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673012837	dimer interface [polypeptide binding]; other site
1036673012838	phosphorylation site [posttranslational modification]
1036673012839	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673012840	ATP binding site [chemical binding]; other site
1036673012841	Mg2+ binding site [ion binding]; other site
1036673012842	G-X-G motif; other site
1036673012843	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673012844	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1036673012845	Walker A/P-loop; other site
1036673012846	ATP binding site [chemical binding]; other site
1036673012847	Q-loop/lid; other site
1036673012848	ABC transporter signature motif; other site
1036673012849	Walker B; other site
1036673012850	D-loop; other site
1036673012851	H-loop/switch region; other site
1036673012852	L-fucose isomerase; Provisional; Region: fucI; PRK10991
1036673012853	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
1036673012854	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1036673012855	trimer interface [polypeptide binding]; other site
1036673012856	substrate binding site [chemical binding]; other site
1036673012857	Mn binding site [ion binding]; other site
1036673012858	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1036673012859	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1036673012860	inhibitor site; inhibition site
1036673012861	active site
1036673012862	dimer interface [polypeptide binding]; other site
1036673012863	catalytic residue [active]
1036673012864	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673012865	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673012866	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673012867	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
1036673012868	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673012869	Interdomain contacts; other site
1036673012870	Cytokine receptor motif; other site
1036673012871	putative pectinesterase; Region: PLN02432; cl01911
1036673012872	Pectinesterase; Region: Pectinesterase; pfam01095
1036673012873	Pectate lyase; Region: Pec_lyase_C; cl01593
1036673012874	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; pfam01177
1036673012875	Abhydrolase family; Region: Abhydrolase_7; pfam12715
1036673012876	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673012877	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673012878	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673012879	S-layer homology domain; Region: SLH; pfam00395
1036673012880	S-layer homology domain; Region: SLH; pfam00395
1036673012881	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036673012882	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036673012883	Walker A/P-loop; other site
1036673012884	ATP binding site [chemical binding]; other site
1036673012885	Q-loop/lid; other site
1036673012886	ABC transporter signature motif; other site
1036673012887	Walker B; other site
1036673012888	D-loop; other site
1036673012889	H-loop/switch region; other site
1036673012890	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1036673012891	FtsX-like permease family; Region: FtsX; pfam02687
1036673012892	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1036673012893	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1036673012894	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036673012895	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036673012896	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036673012897	Walker A/P-loop; other site
1036673012898	ATP binding site [chemical binding]; other site
1036673012899	Q-loop/lid; other site
1036673012900	ABC transporter signature motif; other site
1036673012901	Walker B; other site
1036673012902	D-loop; other site
1036673012903	H-loop/switch region; other site
1036673012904	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
1036673012905	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
1036673012906	DNA binding residues [nucleotide binding]
1036673012907	dimer interface [polypeptide binding]; other site
1036673012908	metal binding site [ion binding]; metal-binding site
1036673012909	S-layer homology domain; Region: SLH; pfam00395
1036673012910	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673012911	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673012912	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673012913	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673012914	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673012915	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012916	dimer interface [polypeptide binding]; other site
1036673012917	conserved gate region; other site
1036673012918	putative PBP binding loops; other site
1036673012919	ABC-ATPase subunit interface; other site
1036673012920	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673012921	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012922	ABC-ATPase subunit interface; other site
1036673012923	NHL repeat; Region: NHL; pfam01436
1036673012924	Yip1 domain; Region: Yip1; pfam04893
1036673012925	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1036673012926	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1036673012927	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1036673012928	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1036673012929	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1036673012930	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673012931	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1036673012932	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1036673012933	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673012934	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673012935	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
1036673012936	Protein of unknown function (DUF4038); Region: DUF4038; pfam13204
1036673012937	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673012938	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673012939	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012940	dimer interface [polypeptide binding]; other site
1036673012941	conserved gate region; other site
1036673012942	ABC-ATPase subunit interface; other site
1036673012943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012944	dimer interface [polypeptide binding]; other site
1036673012945	conserved gate region; other site
1036673012946	putative PBP binding loops; other site
1036673012947	ABC-ATPase subunit interface; other site
1036673012948	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1036673012949	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1036673012950	putative metal binding site [ion binding]; other site
1036673012951	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673012952	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673012953	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1036673012954	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1036673012955	Walker A/P-loop; other site
1036673012956	ATP binding site [chemical binding]; other site
1036673012957	Q-loop/lid; other site
1036673012958	ABC transporter signature motif; other site
1036673012959	Walker B; other site
1036673012960	D-loop; other site
1036673012961	H-loop/switch region; other site
1036673012962	Abhydrolase family; Region: Abhydrolase_7; pfam12715
1036673012963	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673012964	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673012965	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673012966	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673012967	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
1036673012968	BNR repeat-like domain; Region: BNR_2; pfam13088
1036673012969	alpha-glucosidase; Provisional; Region: PRK10137
1036673012970	Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692
1036673012971	BNR repeat-like domain; Region: BNR_2; pfam13088
1036673012972	Alpha-L-fucosidase; Region: Alpha_L_fucos; pfam01120
1036673012973	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
1036673012974	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1036673012975	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1036673012976	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
1036673012977	active site
1036673012978	catalytic triad [active]
1036673012979	oxyanion hole [active]
1036673012980	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1036673012981	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1036673012982	inhibitor site; inhibition site
1036673012983	active site
1036673012984	dimer interface [polypeptide binding]; other site
1036673012985	catalytic residue [active]
1036673012986	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
1036673012987	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1036673012988	putative active site [active]
1036673012989	metal binding site [ion binding]; metal-binding site
1036673012990	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1036673012991	Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979
1036673012992	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1036673012993	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1036673012994	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1036673012995	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673012996	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673012997	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
1036673012998	ABC-ATPase subunit interface; other site
1036673012999	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673013000	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
1036673013001	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673013002	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673013003	dimerization interface [polypeptide binding]; other site
1036673013004	Histidine kinase; Region: His_kinase; pfam06580
1036673013005	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673013006	ATP binding site [chemical binding]; other site
1036673013007	Mg2+ binding site [ion binding]; other site
1036673013008	G-X-G motif; other site
1036673013009	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673013010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673013011	active site
1036673013012	phosphorylation site [posttranslational modification]
1036673013013	intermolecular recognition site; other site
1036673013014	dimerization interface [polypeptide binding]; other site
1036673013015	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673013016	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013017	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673013018	Uncharacterized BCR, COG1649; Region: DUF187; pfam02638
1036673013019	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1036673013020	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673013021	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673013022	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673013023	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673013024	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673013025	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673013026	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673013027	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673013028	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
1036673013029	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1036673013030	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673013031	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1036673013032	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
1036673013033	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1036673013034	Ribulose bisphosphate carboxylase like proteins from nonphototrophic bacteria; Region: RLP_NonPhot; cd08207
1036673013035	Ribulose 1,5-bisphosphate carboxylase, large subunit [Carbohydrate transport and metabolism]; Region: RbcL; COG1850
1036673013036	dimer interface [polypeptide binding]; other site
1036673013037	active site
1036673013038	catalytic residue [active]
1036673013039	metal binding site [ion binding]; metal-binding site
1036673013040	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
1036673013041	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
1036673013042	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1036673013043	active site
1036673013044	intersubunit interface [polypeptide binding]; other site
1036673013045	catalytic residue [active]
1036673013046	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1036673013047	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673013048	NAD(P) binding site [chemical binding]; other site
1036673013049	active site
1036673013050	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
1036673013051	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1036673013052	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1036673013053	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673013054	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013055	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
1036673013056	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1036673013057	N- and C-terminal domain interface [polypeptide binding]; other site
1036673013058	active site
1036673013059	MgATP binding site [chemical binding]; other site
1036673013060	catalytic site [active]
1036673013061	metal binding site [ion binding]; metal-binding site
1036673013062	glycerol binding site [chemical binding]; other site
1036673013063	homotetramer interface [polypeptide binding]; other site
1036673013064	homodimer interface [polypeptide binding]; other site
1036673013065	FBP binding site [chemical binding]; other site
1036673013066	protein IIAGlc interface [polypeptide binding]; other site
1036673013067	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1036673013068	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1036673013069	PYR/PP interface [polypeptide binding]; other site
1036673013070	dimer interface [polypeptide binding]; other site
1036673013071	TPP binding site [chemical binding]; other site
1036673013072	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1036673013073	transketolase; Reviewed; Region: PRK05899
1036673013074	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1036673013075	TPP-binding site [chemical binding]; other site
1036673013076	dimer interface [polypeptide binding]; other site
1036673013077	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
1036673013078	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1036673013079	substrate binding site [chemical binding]; other site
1036673013080	trimer interface [polypeptide binding]; other site
1036673013081	Mn binding site [ion binding]; other site
1036673013082	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673013083	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673013084	DNA binding site [nucleotide binding]
1036673013085	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673013086	ligand binding site [chemical binding]; other site
1036673013087	dimerization interface [polypeptide binding]; other site
1036673013088	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673013089	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013090	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673013091	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013092	putative alpha-glucosidase; Provisional; Region: PRK10658
1036673013093	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
1036673013094	YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593
1036673013095	active site
1036673013096	homotrimer interface [polypeptide binding]; other site
1036673013097	catalytic site [active]
1036673013098	homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site
1036673013099	Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547
1036673013100	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1036673013101	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1036673013102	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1036673013103	conserved cys residue [active]
1036673013104	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1036673013105	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1036673013106	Spore germination protein; Region: Spore_permease; cl17796
1036673013107	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673013108	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673013109	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673013110	Malate:quinone oxidoreductase (Mqo); Region: Mqo; cl17341
1036673013111	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1036673013112	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1036673013113	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673013114	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1036673013115	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1036673013116	ligand binding site [chemical binding]; other site
1036673013117	flexible hinge region; other site
1036673013118	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1036673013119	non-specific DNA interactions [nucleotide binding]; other site
1036673013120	DNA binding site [nucleotide binding]
1036673013121	sequence specific DNA binding site [nucleotide binding]; other site
1036673013122	putative cAMP binding site [chemical binding]; other site
1036673013123	DoxX-like family; Region: DoxX_2; pfam13564
1036673013124	Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901
1036673013125	ADP-ribose binding site [chemical binding]; other site
1036673013126	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673013127	Lipocalin-like domain; Region: Lipocalin_4; pfam13648
1036673013128	DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533
1036673013129	MutS domain III; Region: MutS_III; pfam05192
1036673013130	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673013131	Walker A/P-loop; other site
1036673013132	ATP binding site [chemical binding]; other site
1036673013133	Q-loop/lid; other site
1036673013134	ABC transporter signature motif; other site
1036673013135	Walker B; other site
1036673013136	D-loop; other site
1036673013137	H-loop/switch region; other site
1036673013138	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1036673013139	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673013140	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673013141	active site
1036673013142	phosphorylation site [posttranslational modification]
1036673013143	intermolecular recognition site; other site
1036673013144	dimerization interface [polypeptide binding]; other site
1036673013145	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673013146	DNA binding site [nucleotide binding]
1036673013147	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673013148	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673013149	dimerization interface [polypeptide binding]; other site
1036673013150	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673013151	dimer interface [polypeptide binding]; other site
1036673013152	phosphorylation site [posttranslational modification]
1036673013153	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673013154	ATP binding site [chemical binding]; other site
1036673013155	Mg2+ binding site [ion binding]; other site
1036673013156	G-X-G motif; other site
1036673013157	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673013158	putative substrate translocation pore; other site
1036673013159	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1036673013160	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1036673013161	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673013162	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1036673013163	dimer interface [polypeptide binding]; other site
1036673013164	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673013165	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673013166	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673013167	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673013168	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1036673013169	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1036673013170	putative NAD(P) binding site [chemical binding]; other site
1036673013171	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673013172	putative substrate translocation pore; other site
1036673013173	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673013174	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673013175	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673013176	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1036673013177	dimerization interface [polypeptide binding]; other site
1036673013178	DNA binding domain, excisionase family; Region: excise; TIGR01764
1036673013179	PBP superfamily domain; Region: PBP_like; pfam12727
1036673013180	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1036673013181	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1036673013182	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1036673013183	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013184	dimer interface [polypeptide binding]; other site
1036673013185	ABC-ATPase subunit interface; other site
1036673013186	putative PBP binding loops; other site
1036673013187	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1036673013188	Fibrobacter succinogenes paralogous family TIGR02172; Region: Fb_sc_TIGR02172
1036673013189	active site
1036673013190	substrate binding site [chemical binding]; other site
1036673013191	ATP binding site [chemical binding]; other site
1036673013192	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1036673013193	active site
1036673013194	catalytic triad [active]
1036673013195	oxyanion hole [active]
1036673013196	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1036673013197	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1036673013198	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673013199	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013200	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673013201	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673013202	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673013203	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013204	dimer interface [polypeptide binding]; other site
1036673013205	conserved gate region; other site
1036673013206	putative PBP binding loops; other site
1036673013207	ABC-ATPase subunit interface; other site
1036673013208	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673013209	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013210	ABC-ATPase subunit interface; other site
1036673013211	Domain of unknown function (DUF303); Region: DUF303; pfam03629
1036673013212	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1036673013213	Cytochrome P450; Region: p450; cl12078
1036673013214	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673013215	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673013216	active site
1036673013217	phosphorylation site [posttranslational modification]
1036673013218	intermolecular recognition site; other site
1036673013219	dimerization interface [polypeptide binding]; other site
1036673013220	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673013221	DNA binding site [nucleotide binding]
1036673013222	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673013223	dimerization interface [polypeptide binding]; other site
1036673013224	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673013225	dimer interface [polypeptide binding]; other site
1036673013226	phosphorylation site [posttranslational modification]
1036673013227	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673013228	ATP binding site [chemical binding]; other site
1036673013229	Mg2+ binding site [ion binding]; other site
1036673013230	G-X-G motif; other site
1036673013231	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673013232	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673013233	H+ Antiporter protein; Region: 2A0121; TIGR00900
1036673013234	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673013235	putative substrate translocation pore; other site
1036673013236	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1036673013237	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1036673013238	THF binding site; other site
1036673013239	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1036673013240	substrate binding site [chemical binding]; other site
1036673013241	THF binding site; other site
1036673013242	zinc-binding site [ion binding]; other site
1036673013243	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673013244	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673013245	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673013246	dimerization interface [polypeptide binding]; other site
1036673013247	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036673013248	putative pectinesterase; Region: PLN02432; cl01911
1036673013249	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673013250	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1036673013251	metal binding site [ion binding]; metal-binding site
1036673013252	Family description; Region: VCBS; pfam13517
1036673013253	active site
1036673013254	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673013255	Interdomain contacts; other site
1036673013256	Cytokine receptor motif; other site
1036673013257	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673013258	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1036673013259	active site
1036673013260	metal binding site [ion binding]; metal-binding site
1036673013261	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673013262	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673013263	active site
1036673013264	catalytic tetrad [active]
1036673013265	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1036673013266	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673013267	DNA-binding site [nucleotide binding]; DNA binding site
1036673013268	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673013269	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673013270	homodimer interface [polypeptide binding]; other site
1036673013271	catalytic residue [active]
1036673013272	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1036673013273	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1036673013274	Condensation domain; Region: Condensation; pfam00668
1036673013275	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673013276	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673013277	acyl-activating enzyme (AAE) consensus motif; other site
1036673013278	AMP binding site [chemical binding]; other site
1036673013279	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673013280	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1036673013281	Condensation domain; Region: Condensation; pfam00668
1036673013282	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673013283	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673013284	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673013285	acyl-activating enzyme (AAE) consensus motif; other site
1036673013286	AMP binding site [chemical binding]; other site
1036673013287	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673013288	Condensation domain; Region: Condensation; pfam00668
1036673013289	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673013290	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673013291	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
1036673013292	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1036673013293	N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097
1036673013294	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1036673013295	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1036673013296	active site
1036673013297	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1036673013298	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1036673013299	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1036673013300	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1036673013301	putative NADP binding site [chemical binding]; other site
1036673013302	active site
1036673013303	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673013304	Condensation domain; Region: Condensation; pfam00668
1036673013305	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673013306	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673013307	acyl-activating enzyme (AAE) consensus motif; other site
1036673013308	AMP binding site [chemical binding]; other site
1036673013309	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673013310	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673013311	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013312	dimer interface [polypeptide binding]; other site
1036673013313	conserved gate region; other site
1036673013314	putative PBP binding loops; other site
1036673013315	ABC-ATPase subunit interface; other site
1036673013316	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1036673013317	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013318	putative PBP binding loops; other site
1036673013319	dimer interface [polypeptide binding]; other site
1036673013320	ABC-ATPase subunit interface; other site
1036673013321	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673013322	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673013323	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673013324	Histidine kinase; Region: His_kinase; pfam06580
1036673013325	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673013326	ATP binding site [chemical binding]; other site
1036673013327	Mg2+ binding site [ion binding]; other site
1036673013328	G-X-G motif; other site
1036673013329	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673013330	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673013331	active site
1036673013332	phosphorylation site [posttranslational modification]
1036673013333	intermolecular recognition site; other site
1036673013334	dimerization interface [polypeptide binding]; other site
1036673013335	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673013336	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013337	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1036673013338	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1036673013339	DNA binding residues [nucleotide binding]
1036673013340	dimer interface [polypeptide binding]; other site
1036673013341	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1036673013342	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1036673013343	dimer interface [polypeptide binding]; other site
1036673013344	active site
1036673013345	catalytic residue [active]
1036673013346	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673013347	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673013348	haloalkane dehalogenase; Provisional; Region: PRK03204
1036673013349	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426
1036673013350	RibD C-terminal domain; Region: RibD_C; cl17279
1036673013351	RDD family; Region: RDD; pfam06271
1036673013352	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673013353	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673013354	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673013355	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013356	dimer interface [polypeptide binding]; other site
1036673013357	conserved gate region; other site
1036673013358	putative PBP binding loops; other site
1036673013359	ABC-ATPase subunit interface; other site
1036673013360	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673013361	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013362	dimer interface [polypeptide binding]; other site
1036673013363	conserved gate region; other site
1036673013364	putative PBP binding loops; other site
1036673013365	ABC-ATPase subunit interface; other site
1036673013366	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673013367	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673013368	dimerization interface [polypeptide binding]; other site
1036673013369	Histidine kinase; Region: His_kinase; pfam06580
1036673013370	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673013371	ATP binding site [chemical binding]; other site
1036673013372	Mg2+ binding site [ion binding]; other site
1036673013373	G-X-G motif; other site
1036673013374	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673013375	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673013376	active site
1036673013377	phosphorylation site [posttranslational modification]
1036673013378	intermolecular recognition site; other site
1036673013379	dimerization interface [polypeptide binding]; other site
1036673013380	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673013381	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013382	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013383	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
1036673013384	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1036673013385	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673013386	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1036673013387	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1036673013388	DNA binding residues [nucleotide binding]
1036673013389	putative dimer interface [polypeptide binding]; other site
1036673013390	EamA-like transporter family; Region: EamA; pfam00892
1036673013391	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673013392	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1036673013393	active site
1036673013394	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673013395	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013396	dimer interface [polypeptide binding]; other site
1036673013397	conserved gate region; other site
1036673013398	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673013399	ABC-ATPase subunit interface; other site
1036673013400	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673013401	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013402	dimer interface [polypeptide binding]; other site
1036673013403	conserved gate region; other site
1036673013404	putative PBP binding loops; other site
1036673013405	ABC-ATPase subunit interface; other site
1036673013406	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673013407	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673013408	Histidine kinase; Region: His_kinase; pfam06580
1036673013409	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673013410	ATP binding site [chemical binding]; other site
1036673013411	Mg2+ binding site [ion binding]; other site
1036673013412	G-X-G motif; other site
1036673013413	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
1036673013414	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1036673013415	active site
1036673013416	ATP binding site [chemical binding]; other site
1036673013417	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1036673013418	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673013419	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673013420	DNA binding residues [nucleotide binding]
1036673013421	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1036673013422	Cytochrome P450; Region: p450; cl12078
1036673013423	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
1036673013424	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673013425	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1036673013426	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1036673013427	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1036673013428	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673013429	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013430	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673013431	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013432	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1036673013433	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673013434	DNA-binding site [nucleotide binding]; DNA binding site
1036673013435	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673013436	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673013437	homodimer interface [polypeptide binding]; other site
1036673013438	catalytic residue [active]
1036673013439	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1036673013440	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673013441	DNA-binding site [nucleotide binding]; DNA binding site
1036673013442	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1036673013443	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1036673013444	tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559
1036673013445	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1036673013446	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1036673013447	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1036673013448	inhibitor site; inhibition site
1036673013449	active site
1036673013450	dimer interface [polypeptide binding]; other site
1036673013451	catalytic residue [active]
1036673013452	glucarate dehydratase; Region: glucar-dehydr; TIGR03247
1036673013453	D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323
1036673013454	active site
1036673013455	tetramer interface [polypeptide binding]; other site
1036673013456	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673013457	D-galactonate transporter; Region: 2A0114; TIGR00893
1036673013458	putative substrate translocation pore; other site
1036673013459	CAAX protease self-immunity; Region: Abi; pfam02517
1036673013460	putative acetyltransferase; Provisional; Region: PRK03624
1036673013461	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673013462	Coenzyme A binding pocket [chemical binding]; other site
1036673013463	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412
1036673013464	Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525
1036673013465	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673013466	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013467	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1036673013468	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1036673013469	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673013470	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673013471	active site
1036673013472	phosphorylation site [posttranslational modification]
1036673013473	intermolecular recognition site; other site
1036673013474	dimerization interface [polypeptide binding]; other site
1036673013475	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673013476	non-specific DNA binding site [nucleotide binding]; other site
1036673013477	salt bridge; other site
1036673013478	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673013479	sequence-specific DNA binding site [nucleotide binding]; other site
1036673013480	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013481	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673013482	dimerization interface [polypeptide binding]; other site
1036673013483	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673013484	Histidine kinase; Region: His_kinase; pfam06580
1036673013485	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673013486	ATP binding site [chemical binding]; other site
1036673013487	Mg2+ binding site [ion binding]; other site
1036673013488	G-X-G motif; other site
1036673013489	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673013490	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673013491	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1036673013492	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673013493	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673013494	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673013495	active site
1036673013496	phosphorylation site [posttranslational modification]
1036673013497	intermolecular recognition site; other site
1036673013498	dimerization interface [polypeptide binding]; other site
1036673013499	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673013500	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673013501	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673013502	dimerization interface [polypeptide binding]; other site
1036673013503	Histidine kinase; Region: His_kinase; pfam06580
1036673013504	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673013505	ATP binding site [chemical binding]; other site
1036673013506	Mg2+ binding site [ion binding]; other site
1036673013507	G-X-G motif; other site
1036673013508	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673013509	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673013510	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673013511	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013512	dimer interface [polypeptide binding]; other site
1036673013513	ABC-ATPase subunit interface; other site
1036673013514	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673013515	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013516	dimer interface [polypeptide binding]; other site
1036673013517	conserved gate region; other site
1036673013518	ABC-ATPase subunit interface; other site
1036673013519	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1036673013520	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1036673013521	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1036673013522	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673013523	Interdomain contacts; other site
1036673013524	Cytokine receptor motif; other site
1036673013525	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1036673013526	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673013527	Interdomain contacts; other site
1036673013528	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1036673013529	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1036673013530	Glycosyl hydrolase family 12; Region: Glyco_hydro_12; cl03302
1036673013531	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673013532	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673013533	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673013534	dimerization interface [polypeptide binding]; other site
1036673013535	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1036673013536	EamA-like transporter family; Region: EamA; pfam00892
1036673013537	EamA-like transporter family; Region: EamA; pfam00892
1036673013538	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673013539	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1036673013540	active site
1036673013541	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1036673013542	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1036673013543	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
1036673013544	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673013545	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673013546	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1036673013547	progesterone 5-beta-reductase-like proteins (5beta-POR), atypical (a) SDRs; Region: 5beta-POR_like_SDR_a; cd08948
1036673013548	NAD(P) binding site [chemical binding]; other site
1036673013549	active site
1036673013550	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673013551	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673013552	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673013553	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673013554	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1036673013555	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1036673013556	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
1036673013557	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673013558	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673013559	putative substrate translocation pore; other site
1036673013560	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1036673013561	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
1036673013562	hypothetical protein; Provisional; Region: PRK07206
1036673013563	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673013564	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1036673013565	H+ Antiporter protein; Region: 2A0121; TIGR00900
1036673013566	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673013567	putative substrate translocation pore; other site
1036673013568	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1036673013569	PYR/PP interface [polypeptide binding]; other site
1036673013570	dimer interface [polypeptide binding]; other site
1036673013571	TPP binding site [chemical binding]; other site
1036673013572	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1036673013573	TPP-binding site [chemical binding]; other site
1036673013574	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1036673013575	substrate binding site [chemical binding]; other site
1036673013576	nucleotide binding site [chemical binding]; other site
1036673013577	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1036673013578	N-acetyl-ornithine/N-acetyl-lysine deacetylase; Region: dapE-lys-deAc; TIGR01902
1036673013579	metal binding site [ion binding]; metal-binding site
1036673013580	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1036673013581	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1036673013582	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1036673013583	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1036673013584	inhibitor-cofactor binding pocket; inhibition site
1036673013585	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673013586	catalytic residue [active]
1036673013587	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1036673013588	Lysine biosynthesis enzyme LysX; Region: LysX_arch; TIGR02144
1036673013589	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1036673013590	lysine biosynthesis protein LysW; Region: lysW; TIGR01206
1036673013591	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1036673013592	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1036673013593	catalytic triad [active]
1036673013594	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1036673013595	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013596	dimer interface [polypeptide binding]; other site
1036673013597	conserved gate region; other site
1036673013598	putative PBP binding loops; other site
1036673013599	ABC-ATPase subunit interface; other site
1036673013600	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1036673013601	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013602	dimer interface [polypeptide binding]; other site
1036673013603	conserved gate region; other site
1036673013604	putative PBP binding loops; other site
1036673013605	ABC-ATPase subunit interface; other site
1036673013606	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1036673013607	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673013608	Walker A/P-loop; other site
1036673013609	ATP binding site [chemical binding]; other site
1036673013610	Q-loop/lid; other site
1036673013611	ABC transporter signature motif; other site
1036673013612	Walker B; other site
1036673013613	D-loop; other site
1036673013614	H-loop/switch region; other site
1036673013615	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1036673013616	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1036673013617	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673013618	Walker A/P-loop; other site
1036673013619	ATP binding site [chemical binding]; other site
1036673013620	Q-loop/lid; other site
1036673013621	ABC transporter signature motif; other site
1036673013622	Walker B; other site
1036673013623	D-loop; other site
1036673013624	H-loop/switch region; other site
1036673013625	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1036673013626	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1036673013627	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1036673013628	metal binding site [ion binding]; metal-binding site
1036673013629	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1036673013630	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1036673013631	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673013632	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013633	dimer interface [polypeptide binding]; other site
1036673013634	conserved gate region; other site
1036673013635	putative PBP binding loops; other site
1036673013636	ABC-ATPase subunit interface; other site
1036673013637	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673013638	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673013639	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013640	putative PBP binding loops; other site
1036673013641	dimer interface [polypeptide binding]; other site
1036673013642	ABC-ATPase subunit interface; other site
1036673013643	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673013644	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673013645	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
1036673013646	active site
1036673013647	argininosuccinate lyase; Provisional; Region: PRK06705
1036673013648	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1036673013649	active sites [active]
1036673013650	tetramer interface [polypeptide binding]; other site
1036673013651	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1036673013652	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1036673013653	active site
1036673013654	dimethyl sulfone monooxygenase SfnG; Region: LLM_DMSO2_sfnG; TIGR04021
1036673013655	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1036673013656	active site
1036673013657	dimer interface [polypeptide binding]; other site
1036673013658	non-prolyl cis peptide bond; other site
1036673013659	insertion regions; other site
1036673013660	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
1036673013661	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
1036673013662	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
1036673013663	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673013664	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673013665	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673013666	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1036673013667	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013668	dimer interface [polypeptide binding]; other site
1036673013669	conserved gate region; other site
1036673013670	putative PBP binding loops; other site
1036673013671	ABC-ATPase subunit interface; other site
1036673013672	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673013673	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673013674	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1036673013675	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
1036673013676	active site
1036673013677	dimer interface [polypeptide binding]; other site
1036673013678	non-prolyl cis peptide bond; other site
1036673013679	insertion regions; other site
1036673013680	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673013681	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673013682	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013683	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013684	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013685	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673013686	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013687	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1036673013688	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673013689	NAD(P) binding site [chemical binding]; other site
1036673013690	active site
1036673013691	SnoaL-like domain; Region: SnoaL_4; pfam13577
1036673013692	SnoaL-like domain; Region: SnoaL_4; cl17707
1036673013693	Protein of unknown function (DUF1579); Region: DUF1579; pfam07617
1036673013694	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1036673013695	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1036673013696	active site residue [active]
1036673013697	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1036673013698	active site residue [active]
1036673013699	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1036673013700	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1036673013701	active site
1036673013702	non-prolyl cis peptide bond; other site
1036673013703	putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036
1036673013704	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1036673013705	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1036673013706	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673013707	Coenzyme A binding pocket [chemical binding]; other site
1036673013708	N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259
1036673013709	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1036673013710	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1036673013711	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1036673013712	metal binding site [ion binding]; metal-binding site
1036673013713	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673013714	Coenzyme A binding pocket [chemical binding]; other site
1036673013715	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1036673013716	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1036673013717	Walker A/P-loop; other site
1036673013718	ATP binding site [chemical binding]; other site
1036673013719	Q-loop/lid; other site
1036673013720	ABC transporter signature motif; other site
1036673013721	Walker B; other site
1036673013722	D-loop; other site
1036673013723	H-loop/switch region; other site
1036673013724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013725	dimer interface [polypeptide binding]; other site
1036673013726	conserved gate region; other site
1036673013727	putative PBP binding loops; other site
1036673013728	ABC-ATPase subunit interface; other site
1036673013729	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1036673013730	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013731	dimer interface [polypeptide binding]; other site
1036673013732	conserved gate region; other site
1036673013733	putative PBP binding loops; other site
1036673013734	ABC-ATPase subunit interface; other site
1036673013735	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1036673013736	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673013737	substrate binding pocket [chemical binding]; other site
1036673013738	membrane-bound complex binding site; other site
1036673013739	hinge residues; other site
1036673013740	DinB superfamily; Region: DinB_2; pfam12867
1036673013741	metal-dependent hydrolase; Provisional; Region: PRK13291
1036673013742	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
1036673013743	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673013744	Walker A/P-loop; other site
1036673013745	ATP binding site [chemical binding]; other site
1036673013746	Q-loop/lid; other site
1036673013747	ABC transporter signature motif; other site
1036673013748	Walker B; other site
1036673013749	D-loop; other site
1036673013750	H-loop/switch region; other site
1036673013751	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1036673013752	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1036673013753	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673013754	Walker A/P-loop; other site
1036673013755	ATP binding site [chemical binding]; other site
1036673013756	Q-loop/lid; other site
1036673013757	ABC transporter signature motif; other site
1036673013758	Walker B; other site
1036673013759	D-loop; other site
1036673013760	H-loop/switch region; other site
1036673013761	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1036673013762	nickel transporter permease NikC; Provisional; Region: nikC; PRK10417
1036673013763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013764	ABC-ATPase subunit interface; other site
1036673013765	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1036673013766	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013767	dimer interface [polypeptide binding]; other site
1036673013768	conserved gate region; other site
1036673013769	putative PBP binding loops; other site
1036673013770	ABC-ATPase subunit interface; other site
1036673013771	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1036673013772	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492
1036673013773	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1036673013774	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1036673013775	active site
1036673013776	non-prolyl cis peptide bond; other site
1036673013777	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1036673013778	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1036673013779	cell density-dependent motility repressor; Provisional; Region: PRK10082
1036673013780	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673013781	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673013782	dimerization interface [polypeptide binding]; other site
1036673013783	DoxX-like family; Region: DoxX_2; pfam13564
1036673013784	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1036673013785	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1036673013786	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1036673013787	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1036673013788	Sulfatase; Region: Sulfatase; pfam00884
1036673013789	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1036673013790	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036673013791	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013792	dimer interface [polypeptide binding]; other site
1036673013793	conserved gate region; other site
1036673013794	putative PBP binding loops; other site
1036673013795	ABC-ATPase subunit interface; other site
1036673013796	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1036673013797	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1036673013798	Walker A/P-loop; other site
1036673013799	ATP binding site [chemical binding]; other site
1036673013800	Q-loop/lid; other site
1036673013801	ABC transporter signature motif; other site
1036673013802	Walker B; other site
1036673013803	D-loop; other site
1036673013804	H-loop/switch region; other site
1036673013805	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1036673013806	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673013807	substrate binding pocket [chemical binding]; other site
1036673013808	membrane-bound complex binding site; other site
1036673013809	hinge residues; other site
1036673013810	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673013811	MarR family; Region: MarR; pfam01047
1036673013812	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1036673013813	Sulfatase; Region: Sulfatase; cl17466
1036673013814	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673013815	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673013816	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673013817	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013818	dimer interface [polypeptide binding]; other site
1036673013819	conserved gate region; other site
1036673013820	ABC-ATPase subunit interface; other site
1036673013821	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673013822	N-terminal catalytic domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_N; cd10320
1036673013823	active site
1036673013824	catalytic site [active]
1036673013825	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
1036673013826	C-terminal domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_C; cd10317
1036673013827	Ca binding site [ion binding]; other site
1036673013828	substrate binding site [chemical binding]; other site
1036673013829	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673013830	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013831	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036673013832	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013833	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1036673013834	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1036673013835	active site
1036673013836	non-prolyl cis peptide bond; other site
1036673013837	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1036673013838	RNA polymerase sigma factor, SigM family; Region: SigM_subfam; TIGR02950
1036673013839	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673013840	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1036673013841	DNA binding residues [nucleotide binding]
1036673013842	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
1036673013843	nudix motif; other site
1036673013844	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
1036673013845	short chain dehydrogenase; Provisional; Region: PRK07326
1036673013846	NADP binding site [chemical binding]; other site
1036673013847	homodimer interface [polypeptide binding]; other site
1036673013848	active site
1036673013849	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1036673013850	dimer interface [polypeptide binding]; other site
1036673013851	substrate binding site [chemical binding]; other site
1036673013852	metal binding site [ion binding]; metal-binding site
1036673013853	Protein of unknown function (DUF817); Region: DUF817; pfam05675
1036673013854	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1036673013855	metal-binding site [ion binding]
1036673013856	Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273
1036673013857	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
1036673013858	active site
1036673013859	catalytic residues [active]
1036673013860	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1036673013861	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1036673013862	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1036673013863	Protein of unknown function (DUF1533); Region: DUF1533; pfam07550
1036673013864	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
1036673013865	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673013866	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673013867	DNA binding site [nucleotide binding]
1036673013868	domain linker motif; other site
1036673013869	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673013870	dimerization interface [polypeptide binding]; other site
1036673013871	ligand binding site [chemical binding]; other site
1036673013872	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673013873	dimerization interface [polypeptide binding]; other site
1036673013874	putative DNA binding site [nucleotide binding]; other site
1036673013875	putative Zn2+ binding site [ion binding]; other site
1036673013876	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673013877	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673013878	dimer interface [polypeptide binding]; other site
1036673013879	phosphorylation site [posttranslational modification]
1036673013880	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673013881	ATP binding site [chemical binding]; other site
1036673013882	Mg2+ binding site [ion binding]; other site
1036673013883	G-X-G motif; other site
1036673013884	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673013885	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673013886	active site
1036673013887	phosphorylation site [posttranslational modification]
1036673013888	intermolecular recognition site; other site
1036673013889	dimerization interface [polypeptide binding]; other site
1036673013890	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673013891	DNA binding site [nucleotide binding]
1036673013892	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1036673013893	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1036673013894	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1036673013895	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673013896	Walker A/P-loop; other site
1036673013897	ATP binding site [chemical binding]; other site
1036673013898	Q-loop/lid; other site
1036673013899	ABC transporter signature motif; other site
1036673013900	Walker B; other site
1036673013901	D-loop; other site
1036673013902	H-loop/switch region; other site
1036673013903	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673013904	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673013905	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673013906	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013907	dimer interface [polypeptide binding]; other site
1036673013908	conserved gate region; other site
1036673013909	putative PBP binding loops; other site
1036673013910	ABC-ATPase subunit interface; other site
1036673013911	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1036673013912	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673013913	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673013914	putative PBP binding loops; other site
1036673013915	dimer interface [polypeptide binding]; other site
1036673013916	ABC-ATPase subunit interface; other site
1036673013917	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673013918	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673013919	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673013920	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673013921	active site
1036673013922	phosphorylation site [posttranslational modification]
1036673013923	intermolecular recognition site; other site
1036673013924	dimerization interface [polypeptide binding]; other site
1036673013925	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013926	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673013927	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013928	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673013929	HAMP domain; Region: HAMP; pfam00672
1036673013930	Histidine kinase; Region: His_kinase; pfam06580
1036673013931	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673013932	ATP binding site [chemical binding]; other site
1036673013933	Mg2+ binding site [ion binding]; other site
1036673013934	G-X-G motif; other site
1036673013935	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495
1036673013936	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1036673013937	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1036673013938	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036673013939	active site
1036673013940	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
1036673013941	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
1036673013942	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673013943	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673013944	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1036673013945	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673013946	DNA-binding site [nucleotide binding]; DNA binding site
1036673013947	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673013948	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673013949	homodimer interface [polypeptide binding]; other site
1036673013950	catalytic residue [active]
1036673013951	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1036673013952	EamA-like transporter family; Region: EamA; pfam00892
1036673013953	EamA-like transporter family; Region: EamA; pfam00892
1036673013954	Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124
1036673013955	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1036673013956	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1036673013957	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1036673013958	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1036673013959	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673013960	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673013961	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673013962	active site
1036673013963	catalytic tetrad [active]
1036673013964	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673013965	Spore germination protein; Region: Spore_permease; cl17796
1036673013966	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673013967	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673013968	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1036673013969	putative trimer interface [polypeptide binding]; other site
1036673013970	putative CoA binding site [chemical binding]; other site
1036673013971	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1036673013972	putative trimer interface [polypeptide binding]; other site
1036673013973	putative CoA binding site [chemical binding]; other site
1036673013974	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1036673013975	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036673013976	Walker A/P-loop; other site
1036673013977	ATP binding site [chemical binding]; other site
1036673013978	Q-loop/lid; other site
1036673013979	ABC transporter signature motif; other site
1036673013980	Walker B; other site
1036673013981	D-loop; other site
1036673013982	H-loop/switch region; other site
1036673013983	Condensation domain; Region: Condensation; pfam00668
1036673013984	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673013985	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673013986	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1036673013987	acyl-activating enzyme (AAE) consensus motif; other site
1036673013988	AMP binding site [chemical binding]; other site
1036673013989	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673013990	Condensation domain; Region: Condensation; pfam00668
1036673013991	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673013992	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673013993	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673013994	acyl-activating enzyme (AAE) consensus motif; other site
1036673013995	AMP binding site [chemical binding]; other site
1036673013996	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673013997	Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403
1036673013998	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1036673013999	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
1036673014000	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1036673014001	trimer interface [polypeptide binding]; other site
1036673014002	active site
1036673014003	substrate binding site [chemical binding]; other site
1036673014004	CoA binding site [chemical binding]; other site
1036673014005	H+ Antiporter protein; Region: 2A0121; TIGR00900
1036673014006	2,3-diaminopropionate biosynthesis protein SbnB; Region: dehyd_SbnB_fam; TIGR03944
1036673014007	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1036673014008	2,3-diaminopropionate biosynthesis protein SbnA; Region: PLP_SbnA_fam; TIGR03945
1036673014009	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1036673014010	dimer interface [polypeptide binding]; other site
1036673014011	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673014012	catalytic residue [active]
1036673014013	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014014	acyl-activating enzyme (AAE) consensus motif; other site
1036673014015	AMP binding site [chemical binding]; other site
1036673014016	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014017	Condensation domain; Region: Condensation; pfam00668
1036673014018	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014019	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673014020	Condensation domain; Region: Condensation; pfam00668
1036673014021	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673014022	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014023	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673014024	acyl-activating enzyme (AAE) consensus motif; other site
1036673014025	AMP binding site [chemical binding]; other site
1036673014026	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014027	peptide synthase; Provisional; Region: PRK12467
1036673014028	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
1036673014029	acyl-activating enzyme (AAE) consensus motif; other site
1036673014030	AMP binding site [chemical binding]; other site
1036673014031	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014032	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673014033	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673014034	acyl-activating enzyme (AAE) consensus motif; other site
1036673014035	AMP binding site [chemical binding]; other site
1036673014036	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014037	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673014038	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014039	acyl-activating enzyme (AAE) consensus motif; other site
1036673014040	AMP binding site [chemical binding]; other site
1036673014041	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014042	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673014043	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673014044	acyl-activating enzyme (AAE) consensus motif; other site
1036673014045	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673014046	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673014047	active site
1036673014048	phosphorylation site [posttranslational modification]
1036673014049	dimerization interface [polypeptide binding]; other site
1036673014050	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673014051	DNA binding site [nucleotide binding]
1036673014052	CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622
1036673014053	CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252
1036673014054	NAD binding site [chemical binding]; other site
1036673014055	homotetramer interface [polypeptide binding]; other site
1036673014056	homodimer interface [polypeptide binding]; other site
1036673014057	substrate binding site [chemical binding]; other site
1036673014058	active site
1036673014059	A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399
1036673014060	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
1036673014061	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
1036673014062	dimer interface [polypeptide binding]; other site
1036673014063	active site
1036673014064	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1036673014065	catalytic residues [active]
1036673014066	substrate binding site [chemical binding]; other site
1036673014067	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1036673014068	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1036673014069	active site
1036673014070	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1036673014071	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1036673014072	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1036673014073	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
1036673014074	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673014075	Walker A/P-loop; other site
1036673014076	ATP binding site [chemical binding]; other site
1036673014077	Q-loop/lid; other site
1036673014078	ABC transporter signature motif; other site
1036673014079	Walker B; other site
1036673014080	D-loop; other site
1036673014081	H-loop/switch region; other site
1036673014082	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673014083	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673014084	tungsten cofactor oxidoreducase radical SAM maturase; Region: W_rSAM_matur; TIGR04317
1036673014085	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673014086	FeS/SAM binding site; other site
1036673014087	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
1036673014088	diacylglycerol glucosyltransferase; Provisional; Region: PRK13608
1036673014089	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
1036673014090	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1036673014091	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1036673014092	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
1036673014093	substrate binding site [chemical binding]; other site
1036673014094	active site
1036673014095	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1036673014096	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673014097	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673014098	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
1036673014099	3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases [Coenzyme metabolism]; Region: UbiD; COG0043
1036673014100	putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923
1036673014101	transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894
1036673014102	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1036673014103	cyclase homology domain; Region: CHD; cd07302
1036673014104	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1036673014105	nucleotidyl binding site; other site
1036673014106	metal binding site [ion binding]; metal-binding site
1036673014107	dimer interface [polypeptide binding]; other site
1036673014108	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1036673014109	cyclase homology domain; Region: CHD; cd07302
1036673014110	nucleotidyl binding site; other site
1036673014111	metal binding site [ion binding]; metal-binding site
1036673014112	dimer interface [polypeptide binding]; other site
1036673014113	Predicted ATPase [General function prediction only]; Region: COG3899
1036673014114	AAA ATPase domain; Region: AAA_16; pfam13191
1036673014115	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1036673014116	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
1036673014117	sulfite reductase subunit beta; Provisional; Region: PRK13504
1036673014118	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1036673014119	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1036673014120	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
1036673014121	Flavodoxin; Region: Flavodoxin_1; pfam00258
1036673014122	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
1036673014123	FAD binding pocket [chemical binding]; other site
1036673014124	FAD binding motif [chemical binding]; other site
1036673014125	catalytic residues [active]
1036673014126	NAD binding pocket [chemical binding]; other site
1036673014127	phosphate binding motif [ion binding]; other site
1036673014128	beta-alpha-beta structure motif; other site
1036673014129	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
1036673014130	Calx-beta domain; Region: Calx-beta; pfam03160
1036673014131	Domains in Na-Ca exchangers and integrin-beta4; Region: Calx_beta; smart00237
1036673014132	Calx-beta domain; Region: Calx-beta; cl02522
1036673014133	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673014134	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1036673014135	Walker A motif; other site
1036673014136	ATP binding site [chemical binding]; other site
1036673014137	Walker B motif; other site
1036673014138	arginine finger; other site
1036673014139	UvrB/uvrC motif; Region: UVR; pfam02151
1036673014140	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673014141	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1036673014142	Walker A motif; other site
1036673014143	ATP binding site [chemical binding]; other site
1036673014144	Walker B motif; other site
1036673014145	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1036673014146	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673014147	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673014148	CHASE3 domain; Region: CHASE3; cl05000
1036673014149	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673014150	dimerization interface [polypeptide binding]; other site
1036673014151	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673014152	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673014153	dimer interface [polypeptide binding]; other site
1036673014154	putative CheW interface [polypeptide binding]; other site
1036673014155	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673014156	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
1036673014157	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1036673014158	Predicted transcriptional regulator [Transcription]; Region: COG2378
1036673014159	HTH domain; Region: HTH_11; pfam08279
1036673014160	WYL domain; Region: WYL; pfam13280
1036673014161	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673014162	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673014163	Spore germination protein; Region: Spore_permease; cl17796
1036673014164	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673014165	Chromate resistance exported protein; Region: Chrome_Resist; pfam09828
1036673014166	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1036673014167	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
1036673014168	Chromate transporter; Region: Chromate_transp; pfam02417
1036673014169	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1036673014170	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673014171	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673014172	dimer interface [polypeptide binding]; other site
1036673014173	phosphorylation site [posttranslational modification]
1036673014174	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673014175	ATP binding site [chemical binding]; other site
1036673014176	Mg2+ binding site [ion binding]; other site
1036673014177	G-X-G motif; other site
1036673014178	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673014179	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673014180	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673014181	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673014182	acyl-activating enzyme (AAE) consensus motif; other site
1036673014183	AMP binding site [chemical binding]; other site
1036673014184	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014185	Condensation domain; Region: Condensation; pfam00668
1036673014186	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014187	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673014188	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673014189	acyl-activating enzyme (AAE) consensus motif; other site
1036673014190	AMP binding site [chemical binding]; other site
1036673014191	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014192	Condensation domain; Region: Condensation; pfam00668
1036673014193	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014194	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673014195	Condensation domain; Region: Condensation; pfam00668
1036673014196	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014197	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014198	acyl-activating enzyme (AAE) consensus motif; other site
1036673014199	AMP binding site [chemical binding]; other site
1036673014200	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014201	Thioesterase domain; Region: Thioesterase; pfam00975
1036673014202	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673014203	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014204	Condensation domain; Region: Condensation; pfam00668
1036673014205	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014206	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673014207	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673014208	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014209	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673014210	acyl-activating enzyme (AAE) consensus motif; other site
1036673014211	AMP binding site [chemical binding]; other site
1036673014212	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014213	Condensation domain; Region: Condensation; pfam00668
1036673014214	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014215	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673014216	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014217	acyl-activating enzyme (AAE) consensus motif; other site
1036673014218	AMP binding site [chemical binding]; other site
1036673014219	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014220	Condensation domain; Region: Condensation; pfam00668
1036673014221	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014222	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673014223	Condensation domain; Region: Condensation; pfam00668
1036673014224	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014225	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014226	acyl-activating enzyme (AAE) consensus motif; other site
1036673014227	AMP binding site [chemical binding]; other site
1036673014228	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014229	Condensation domain; Region: Condensation; pfam00668
1036673014230	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014231	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673014232	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014233	acyl-activating enzyme (AAE) consensus motif; other site
1036673014234	AMP binding site [chemical binding]; other site
1036673014235	Condensation domain; Region: Condensation; pfam00668
1036673014236	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014237	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1036673014238	acyl-activating enzyme (AAE) consensus motif; other site
1036673014239	AMP binding site [chemical binding]; other site
1036673014240	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014241	Condensation domain; Region: Condensation; pfam00668
1036673014242	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014243	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673014244	Condensation domain; Region: Condensation; pfam00668
1036673014245	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014246	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014247	acyl-activating enzyme (AAE) consensus motif; other site
1036673014248	AMP binding site [chemical binding]; other site
1036673014249	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014250	Condensation domain; Region: Condensation; pfam00668
1036673014251	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014252	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673014253	Condensation domain; Region: Condensation; pfam00668
1036673014254	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014255	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117
1036673014256	acyl-activating enzyme (AAE) consensus motif; other site
1036673014257	AMP binding site [chemical binding]; other site
1036673014258	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014259	Condensation domain; Region: Condensation; pfam00668
1036673014260	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014261	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673014262	Condensation domain; Region: Condensation; pfam00668
1036673014263	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014264	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014265	acyl-activating enzyme (AAE) consensus motif; other site
1036673014266	AMP binding site [chemical binding]; other site
1036673014267	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014268	Condensation domain; Region: Condensation; pfam00668
1036673014269	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014270	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673014271	Condensation domain; Region: Condensation; pfam00668
1036673014272	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014273	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014274	acyl-activating enzyme (AAE) consensus motif; other site
1036673014275	AMP binding site [chemical binding]; other site
1036673014276	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014277	Condensation domain; Region: Condensation; pfam00668
1036673014278	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
1036673014279	Condensation domain; Region: Condensation; pfam00668
1036673014280	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014281	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014282	acyl-activating enzyme (AAE) consensus motif; other site
1036673014283	AMP binding site [chemical binding]; other site
1036673014284	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014285	Condensation domain; Region: Condensation; pfam00668
1036673014286	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014287	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673014288	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673014289	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673014290	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
1036673014291	Walker A/P-loop; other site
1036673014292	ATP binding site [chemical binding]; other site
1036673014293	Q-loop/lid; other site
1036673014294	ABC transporter signature motif; other site
1036673014295	Walker B; other site
1036673014296	D-loop; other site
1036673014297	H-loop/switch region; other site
1036673014298	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673014299	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673014300	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673014301	Walker A/P-loop; other site
1036673014302	ATP binding site [chemical binding]; other site
1036673014303	Q-loop/lid; other site
1036673014304	ABC transporter signature motif; other site
1036673014305	Walker B; other site
1036673014306	D-loop; other site
1036673014307	H-loop/switch region; other site
1036673014308	diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264
1036673014309	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036673014310	inhibitor-cofactor binding pocket; inhibition site
1036673014311	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673014312	catalytic residue [active]
1036673014313	VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762
1036673014314	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1036673014315	metal ion-dependent adhesion site (MIDAS); other site
1036673014316	TraB family; Region: TraB; cl12050
1036673014317	MoxR-like ATPases [General function prediction only]; Region: COG0714
1036673014318	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
1036673014319	Walker A motif; other site
1036673014320	ATP binding site [chemical binding]; other site
1036673014321	Walker B motif; other site
1036673014322	arginine finger; other site
1036673014323	SWIM zinc finger; Region: SWIM; pfam04434
1036673014324	metal-dependent hydrolase; Provisional; Region: PRK13291
1036673014325	DinB superfamily; Region: DinB_2; pfam12867
1036673014326	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
1036673014327	Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405
1036673014328	iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652
1036673014329	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1036673014330	radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053
1036673014331	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673014332	FeS/SAM binding site; other site
1036673014333	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1036673014334	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1036673014335	Uncharacterized conserved protein (DUF2249); Region: DUF2249; pfam10006
1036673014336	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1036673014337	CPxP  motif; other site
1036673014338	protoporphyrinogen oxidase; Reviewed; Region: PRK11883
1036673014339	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036673014340	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036673014341	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1036673014342	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673014343	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673014344	alpha-ketoglutarate transporter; Provisional; Region: PRK10406
1036673014345	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673014346	putative substrate translocation pore; other site
1036673014347	Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152
1036673014348	Phosphotransferase enzyme family; Region: APH; pfam01636
1036673014349	putative active site [active]
1036673014350	putative substrate binding site [chemical binding]; other site
1036673014351	ATP binding site [chemical binding]; other site
1036673014352	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1036673014353	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1036673014354	dimer interface [polypeptide binding]; other site
1036673014355	active site
1036673014356	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673014357	salt bridge; other site
1036673014358	non-specific DNA binding site [nucleotide binding]; other site
1036673014359	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1036673014360	sequence-specific DNA binding site [nucleotide binding]; other site
1036673014361	aminoglycoside resistance protein; Provisional; Region: PRK13746
1036673014362	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1036673014363	active site
1036673014364	NTP binding site [chemical binding]; other site
1036673014365	metal binding triad [ion binding]; metal-binding site
1036673014366	antibiotic binding site [chemical binding]; other site
1036673014367	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1036673014368	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1036673014369	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673014370	S-adenosylmethionine binding site [chemical binding]; other site
1036673014371	Carbohydrate binding domain X2; Region: CBM_X2; pfam03442
1036673014372	Cellulose binding domain; Region: CBM_3; pfam00942
1036673014373	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
1036673014374	hypothetical protein; Provisional; Region: PRK12378
1036673014375	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673014376	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1036673014377	NAD(P) binding site [chemical binding]; other site
1036673014378	active site
1036673014379	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1036673014380	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673014381	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673014382	The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438
1036673014383	putative dimerization interface [polypeptide binding]; other site
1036673014384	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1036673014385	Amidohydrolase; Region: Amidohydro_2; pfam04909
1036673014386	Predicted metalloprotease [General function prediction only]; Region: COG2321
1036673014387	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1036673014388	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1036673014389	H+ Antiporter protein; Region: 2A0121; TIGR00900
1036673014390	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673014391	putative substrate translocation pore; other site
1036673014392	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
1036673014393	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1036673014394	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; cl01132
1036673014395	enterobactin synthase subunit F; Provisional; Region: entF; PRK10252
1036673014396	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673014397	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014398	acyl-activating enzyme (AAE) consensus motif; other site
1036673014399	AMP binding site [chemical binding]; other site
1036673014400	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014401	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
1036673014402	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
1036673014403	active site
1036673014404	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1036673014405	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1036673014406	active site
1036673014407	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1036673014408	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1036673014409	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673014410	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014411	Condensation domain; Region: Condensation; pfam00668
1036673014412	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014413	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673014414	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014415	acyl-activating enzyme (AAE) consensus motif; other site
1036673014416	AMP binding site [chemical binding]; other site
1036673014417	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014418	Condensation domain; Region: Condensation; pfam00668
1036673014419	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014420	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673014421	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014422	acyl-activating enzyme (AAE) consensus motif; other site
1036673014423	AMP binding site [chemical binding]; other site
1036673014424	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014425	acyl-CoA synthetase; Validated; Region: PRK05850
1036673014426	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
1036673014427	acyl-activating enzyme (AAE) consensus motif; other site
1036673014428	active site
1036673014429	Phosphopantetheine attachment site; Region: PKS_PP; smart00823
1036673014430	Condensation domain; Region: Condensation; pfam00668
1036673014431	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
1036673014432	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
1036673014433	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1036673014434	acyl-activating enzyme (AAE) consensus motif; other site
1036673014435	AMP binding site [chemical binding]; other site
1036673014436	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1036673014437	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673014438	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673014439	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673014440	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
1036673014441	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606
1036673014442	oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289
1036673014443	active site
1036673014444	Zn binding site [ion binding]; other site
1036673014445	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1036673014446	dimer interface [polypeptide binding]; other site
1036673014447	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673014448	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1036673014449	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1036673014450	Predicted transcriptional regulators [Transcription]; Region: COG1378
1036673014451	Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978
1036673014452	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1036673014453	putative active site [active]
1036673014454	catalytic site [active]
1036673014455	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1036673014456	FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289
1036673014457	active site
1036673014458	Class I aldolases; Region: Aldolase_Class_I; cl17187
1036673014459	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1036673014460	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
1036673014461	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1036673014462	Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961
1036673014463	Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038
1036673014464	dimer interface [polypeptide binding]; other site
1036673014465	PYR/PP interface [polypeptide binding]; other site
1036673014466	TPP binding site [chemical binding]; other site
1036673014467	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1036673014468	Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005
1036673014469	TPP-binding site [chemical binding]; other site
1036673014470	dimer interface [polypeptide binding]; other site
1036673014471	Uncharacterized conserved protein [Function unknown]; Region: COG2135
1036673014472	Cache domain; Region: Cache_1; pfam02743
1036673014473	HAMP domain; Region: HAMP; pfam00672
1036673014474	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673014475	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673014476	metal binding site [ion binding]; metal-binding site
1036673014477	active site
1036673014478	I-site; other site
1036673014479	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087
1036673014480	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1036673014481	Part of AAA domain; Region: AAA_19; pfam13245
1036673014482	Family description; Region: UvrD_C_2; pfam13538
1036673014483	putative transporter; Provisional; Region: PRK11021
1036673014484	Spore germination protein; Region: Spore_permease; cl17796
1036673014485	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1036673014486	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673014487	DNA-binding site [nucleotide binding]; DNA binding site
1036673014488	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673014489	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673014490	homodimer interface [polypeptide binding]; other site
1036673014491	catalytic residue [active]
1036673014492	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673014493	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
1036673014494	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
1036673014495	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673014496	Domain of unknown function (DUF4362); Region: DUF4362; pfam14275
1036673014497	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
1036673014498	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1036673014499	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395
1036673014500	2-keto-3-deoxygluconate permease; Provisional; Region: PRK05274
1036673014501	Propionate catabolism activator; Region: PrpR_N; pfam06506
1036673014502	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1036673014503	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673014504	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1036673014505	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1036673014506	Chitin binding domain; Region: Chitin_bind_3; pfam03067
1036673014507	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
1036673014508	aromatic chitin/cellulose binding site residues [chemical binding]; other site
1036673014509	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
1036673014510	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673014511	Interdomain contacts; other site
1036673014512	Cytokine receptor motif; other site
1036673014513	Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439
1036673014514	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1036673014515	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673014516	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673014517	DNA binding site [nucleotide binding]
1036673014518	domain linker motif; other site
1036673014519	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673014520	dimerization interface [polypeptide binding]; other site
1036673014521	ligand binding site [chemical binding]; other site
1036673014522	tellurium resistance terB-like protein; Region: terB_like; cd07177
1036673014523	metal binding site [ion binding]; metal-binding site
1036673014524	Cytochrome P450; Region: p450; pfam00067
1036673014525	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1036673014526	DinB superfamily; Region: DinB_2; pfam12867
1036673014527	protoporphyrinogen oxidase; Provisional; Region: PRK12416
1036673014528	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036673014529	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1036673014530	VanZ like family; Region: VanZ; cl01971
1036673014531	RDD family; Region: RDD; pfam06271
1036673014532	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1036673014533	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
1036673014534	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1036673014535	substrate binding site [chemical binding]; other site
1036673014536	catalytic residues [active]
1036673014537	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673014538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673014539	active site
1036673014540	phosphorylation site [posttranslational modification]
1036673014541	intermolecular recognition site; other site
1036673014542	dimerization interface [polypeptide binding]; other site
1036673014543	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673014544	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673014545	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1036673014546	dimerization interface [polypeptide binding]; other site
1036673014547	Histidine kinase; Region: His_kinase; pfam06580
1036673014548	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673014549	ATP binding site [chemical binding]; other site
1036673014550	Mg2+ binding site [ion binding]; other site
1036673014551	G-X-G motif; other site
1036673014552	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673014553	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673014554	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673014555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673014556	dimer interface [polypeptide binding]; other site
1036673014557	conserved gate region; other site
1036673014558	putative PBP binding loops; other site
1036673014559	ABC-ATPase subunit interface; other site
1036673014560	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1036673014561	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673014562	dimer interface [polypeptide binding]; other site
1036673014563	conserved gate region; other site
1036673014564	putative PBP binding loops; other site
1036673014565	ABC-ATPase subunit interface; other site
1036673014566	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673014567	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673014568	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1036673014569	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673014570	putative substrate translocation pore; other site
1036673014571	CutC family; Region: CutC; cl01218
1036673014572	Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142
1036673014573	RNAase interaction site [polypeptide binding]; other site
1036673014574	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1036673014575	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
1036673014576	NAD binding site [chemical binding]; other site
1036673014577	dimer interface [polypeptide binding]; other site
1036673014578	substrate binding site [chemical binding]; other site
1036673014579	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1036673014580	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1036673014581	Nicotianamine synthase protein; Region: NAS; cl17658
1036673014582	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1036673014583	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1036673014584	Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424
1036673014585	Chalcone and stilbene synthases; plant-specific polyketide synthases (PKS) and related enzymes, also called type III PKSs. PKS generate an array of different products, dependent on the nature of the starter molecule. They share a common chemical strategy; Region: CHS_like; cd00831
1036673014586	malonyl-CoA binding site [chemical binding]; other site
1036673014587	dimer interface [polypeptide binding]; other site
1036673014588	active site
1036673014589	product binding site; other site
1036673014590	Uncharacterized protein conserved in bacteria (DUF2086); Region: DUF2086; pfam09859
1036673014591	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1036673014592	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1036673014593	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
1036673014594	YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477
1036673014595	[2Fe-2S] cluster binding site [ion binding]; other site
1036673014596	Mannitol repressor; Region: MtlR; cl11450
1036673014597	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1036673014598	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1036673014599	NADP binding site [chemical binding]; other site
1036673014600	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1036673014601	Ycf48-like protein; Provisional; Region: PRK13684
1036673014602	photosystem II stability/assembly factor; Provisional; Region: PLN00033
1036673014603	Protein of unknown function (DUF975); Region: DUF975; cl10504
1036673014604	S-layer homology domain; Region: SLH; pfam00395
1036673014605	S-layer homology domain; Region: SLH; pfam00395
1036673014606	Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386
1036673014607	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1036673014608	Peptidase family M23; Region: Peptidase_M23; pfam01551
1036673014609	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
1036673014610	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673014611	active site
1036673014612	metal binding site [ion binding]; metal-binding site
1036673014613	Spore germination protein; Region: Spore_permease; cl17796
1036673014614	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673014615	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673014616	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673014617	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1036673014618	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
1036673014619	active site
1036673014620	catalytic triad [active]
1036673014621	dimer interface [polypeptide binding]; other site
1036673014622	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1036673014623	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1036673014624	Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101
1036673014625	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673014626	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673014627	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1036673014628	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
1036673014629	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1036673014630	minor groove reading motif; other site
1036673014631	helix-hairpin-helix signature motif; other site
1036673014632	substrate binding pocket [chemical binding]; other site
1036673014633	active site
1036673014634	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1036673014635	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1036673014636	DNA binding site [nucleotide binding]
1036673014637	active site
1036673014638	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1036673014639	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1036673014640	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673014641	Uncharacterized small membrane protein [Function unknown]; Region: COG2363
1036673014642	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1036673014643	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
1036673014644	Domain of unknown function (DUF4375); Region: DUF4375; pfam14300
1036673014645	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673014646	putative substrate translocation pore; other site
1036673014647	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1036673014648	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673014649	heat shock protein 90; Provisional; Region: PRK05218
1036673014650	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673014651	ATP binding site [chemical binding]; other site
1036673014652	Mg2+ binding site [ion binding]; other site
1036673014653	G-X-G motif; other site
1036673014654	Squalene/phytoene synthase; Region: SQS_PSY; pfam00494
1036673014655	substrate binding pocket [chemical binding]; other site
1036673014656	substrate-Mg2+ binding site; other site
1036673014657	aspartate-rich region 1; other site
1036673014658	aspartate-rich region 2; other site
1036673014659	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1036673014660	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1036673014661	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1036673014662	short chain dehydrogenase; Provisional; Region: PRK07062
1036673014663	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673014664	NAD(P) binding site [chemical binding]; other site
1036673014665	active site
1036673014666	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1036673014667	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1036673014668	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1036673014669	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1036673014670	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1036673014671	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1036673014672	phosphopentomutase; Provisional; Region: PRK05362
1036673014673	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1036673014674	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
1036673014675	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
1036673014676	Nucleoside recognition; Region: Gate; pfam07670
1036673014677	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
1036673014678	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1036673014679	active site
1036673014680	catalytic motif [active]
1036673014681	Zn binding site [ion binding]; other site
1036673014682	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1036673014683	intersubunit interface [polypeptide binding]; other site
1036673014684	active site
1036673014685	catalytic residue [active]
1036673014686	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1036673014687	helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419
1036673014688	non-specific DNA interactions [nucleotide binding]; other site
1036673014689	DNA binding site [nucleotide binding]
1036673014690	sequence specific DNA binding site [nucleotide binding]; other site
1036673014691	putative cAMP binding site [chemical binding]; other site
1036673014692	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1036673014693	DNA polymerase III subunit beta; Validated; Region: PRK05643
1036673014694	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1036673014695	putative DNA binding surface [nucleotide binding]; other site
1036673014696	dimer interface [polypeptide binding]; other site
1036673014697	beta-clamp/clamp loader binding surface; other site
1036673014698	beta-clamp/translesion DNA polymerase binding surface; other site
1036673014699	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1036673014700	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1036673014701	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1036673014702	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1036673014703	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1036673014704	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1036673014705	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1036673014706	dimer interface [polypeptide binding]; other site
1036673014707	FMN binding site [chemical binding]; other site
1036673014708	Rrf2 family protein; Region: rrf2_super; TIGR00738
1036673014709	Transcriptional regulator; Region: Rrf2; pfam02082
1036673014710	YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398
1036673014711	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1036673014712	Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998
1036673014713	substrate binding site [chemical binding]; other site
1036673014714	active site
1036673014715	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1036673014716	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1036673014717	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673014718	Phytochelatin synthase; Region: Phytochelatin; pfam05023
1036673014719	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673014720	dimer interface [polypeptide binding]; other site
1036673014721	conserved gate region; other site
1036673014722	putative PBP binding loops; other site
1036673014723	ABC-ATPase subunit interface; other site
1036673014724	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673014725	dimer interface [polypeptide binding]; other site
1036673014726	conserved gate region; other site
1036673014727	putative PBP binding loops; other site
1036673014728	ABC-ATPase subunit interface; other site
1036673014729	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673014730	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673014731	Predicted transcriptional regulator [Transcription]; Region: COG4189
1036673014732	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673014733	dimerization interface [polypeptide binding]; other site
1036673014734	putative DNA binding site [nucleotide binding]; other site
1036673014735	putative Zn2+ binding site [ion binding]; other site
1036673014736	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1036673014737	NlpC/P60 family; Region: NLPC_P60; pfam00877
1036673014738	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1036673014739	active site
1036673014740	catalytic triad [active]
1036673014741	ParB-like nuclease domain; Region: ParBc; pfam02195
1036673014742	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1036673014743	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1036673014744	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1036673014745	Ca binding site [ion binding]; other site
1036673014746	active site
1036673014747	catalytic site [active]
1036673014748	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673014749	PAS domain; Region: PAS_9; pfam13426
1036673014750	putative active site [active]
1036673014751	heme pocket [chemical binding]; other site
1036673014752	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1036673014753	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1036673014754	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673014755	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673014756	Interdomain contacts; other site
1036673014757	Cytokine receptor motif; other site
1036673014758	Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041
1036673014759	bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109
1036673014760	Moco binding site; other site
1036673014761	metal coordination site [ion binding]; other site
1036673014762	YolD-like protein; Region: YolD; pfam08863
1036673014763	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
1036673014764	dimer interface [polypeptide binding]; other site
1036673014765	[2Fe-2S] cluster binding site [ion binding]; other site
1036673014766	sugar efflux transporter; Region: 2A0120; TIGR00899
1036673014767	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673014768	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1036673014769	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1036673014770	ligand binding site [chemical binding]; other site
1036673014771	flexible hinge region; other site
1036673014772	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1036673014773	Domain of unknown function (DUF4166); Region: DUF4166; pfam13761
1036673014774	DoxX-like family; Region: DoxX_3; pfam13781
1036673014775	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1036673014776	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282
1036673014777	DNA binding residues [nucleotide binding]
1036673014778	putative dimer interface [polypeptide binding]; other site
1036673014779	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1036673014780	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1036673014781	catalytic residues [active]
1036673014782	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1036673014783	metal binding site [ion binding]; metal-binding site
1036673014784	active site
1036673014785	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1036673014786	active site
1036673014787	catalytic triad [active]
1036673014788	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1036673014789	active site
1036673014790	catalytic triad [active]
1036673014791	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
1036673014792	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1036673014793	Domain of unknown function DUF21; Region: DUF21; pfam01595
1036673014794	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1036673014795	Transporter associated domain; Region: CorC_HlyC; smart01091
1036673014796	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1036673014797	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673014798	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673014799	S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462
1036673014800	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673014801	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673014802	putative substrate translocation pore; other site
1036673014803	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673014804	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1036673014805	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1036673014806	protein binding site [polypeptide binding]; other site
1036673014807	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673014808	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1036673014809	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1036673014810	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1036673014811	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673014812	NAD(P) binding site [chemical binding]; other site
1036673014813	active site
1036673014814	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1036673014815	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1036673014816	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1036673014817	active site
1036673014818	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673014819	S-adenosylmethionine binding site [chemical binding]; other site
1036673014820	putative phosphoesterase; Region: acc_ester; TIGR03729
1036673014821	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673014822	Multidrug resistance efflux transporter; Region: EmrE; pfam13536
1036673014823	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14950
1036673014824	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1036673014825	Nitronate monooxygenase; Region: NMO; pfam03060
1036673014826	FMN binding site [chemical binding]; other site
1036673014827	substrate binding site [chemical binding]; other site
1036673014828	putative catalytic residue [active]
1036673014829	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673014830	Coenzyme A binding pocket [chemical binding]; other site
1036673014831	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673014832	HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7
1036673014833	S-layer homology domain; Region: SLH; pfam00395
1036673014834	S-layer homology domain; Region: SLH; pfam00395
1036673014835	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1036673014836	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1036673014837	protein binding site [polypeptide binding]; other site
1036673014838	C-terminal processing peptidase family S41; Region: Peptidase_S41; cd06567
1036673014839	Active site serine [active]
1036673014840	Bacterial Ig-like domain; Region: Big_5; pfam13205
1036673014841	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1036673014842	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1036673014843	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673014844	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1036673014845	Walker A/P-loop; other site
1036673014846	ATP binding site [chemical binding]; other site
1036673014847	Q-loop/lid; other site
1036673014848	ABC transporter signature motif; other site
1036673014849	Walker B; other site
1036673014850	D-loop; other site
1036673014851	H-loop/switch region; other site
1036673014852	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673014853	Coenzyme A binding pocket [chemical binding]; other site
1036673014854	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
1036673014855	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036673014856	Zn2+ binding site [ion binding]; other site
1036673014857	Mg2+ binding site [ion binding]; other site
1036673014858	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1036673014859	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1036673014860	ATP binding site [chemical binding]; other site
1036673014861	Mg2+ binding site [ion binding]; other site
1036673014862	G-X-G motif; other site
1036673014863	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1036673014864	anti sigma factor interaction site; other site
1036673014865	regulatory phosphorylation site [posttranslational modification]; other site
1036673014866	Protein of unknown function (DUF342); Region: DUF342; pfam03961
1036673014867	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673014868	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673014869	active site
1036673014870	phosphorylation site [posttranslational modification]
1036673014871	intermolecular recognition site; other site
1036673014872	dimerization interface [polypeptide binding]; other site
1036673014873	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1036673014874	VPS10 domain; Region: VPS10; smart00602
1036673014875	VPS10 domain; Region: VPS10; smart00602
1036673014876	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
1036673014877	D-amino acid dehydrogenase small subunit; Provisional; Region: PRK12409
1036673014878	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1036673014879	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1036673014880	DNA-binding site [nucleotide binding]; DNA binding site
1036673014881	RNA-binding motif; other site
1036673014882	Rhomboid family; Region: Rhomboid; pfam01694
1036673014883	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1036673014884	Coat F domain; Region: Coat_F; pfam07875
1036673014885	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673014886	active site
1036673014887	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673014888	catalytic tetrad [active]
1036673014889	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1036673014890	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673014891	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673014892	Ion channel; Region: Ion_trans_2; pfam07885
1036673014893	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1036673014894	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
1036673014895	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036673014896	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1036673014897	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673014898	Walker A/P-loop; other site
1036673014899	ATP binding site [chemical binding]; other site
1036673014900	Q-loop/lid; other site
1036673014901	ABC transporter signature motif; other site
1036673014902	Walker B; other site
1036673014903	D-loop; other site
1036673014904	H-loop/switch region; other site
1036673014905	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673014906	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1036673014907	Walker A/P-loop; other site
1036673014908	ATP binding site [chemical binding]; other site
1036673014909	Q-loop/lid; other site
1036673014910	ABC transporter signature motif; other site
1036673014911	Walker B; other site
1036673014912	D-loop; other site
1036673014913	H-loop/switch region; other site
1036673014914	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1036673014915	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1036673014916	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673014917	dimer interface [polypeptide binding]; other site
1036673014918	conserved gate region; other site
1036673014919	putative PBP binding loops; other site
1036673014920	ABC-ATPase subunit interface; other site
1036673014921	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1036673014922	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673014923	dimer interface [polypeptide binding]; other site
1036673014924	conserved gate region; other site
1036673014925	putative PBP binding loops; other site
1036673014926	ABC-ATPase subunit interface; other site
1036673014927	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1036673014928	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1036673014929	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1036673014930	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1036673014931	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673014932	Coenzyme A binding pocket [chemical binding]; other site
1036673014933	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1036673014934	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1036673014935	NAD binding site [chemical binding]; other site
1036673014936	catalytic Zn binding site [ion binding]; other site
1036673014937	structural Zn binding site [ion binding]; other site
1036673014938	Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023
1036673014939	active site
1036673014940	catalytic residues [active]
1036673014941	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1036673014942	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1036673014943	putative sugar binding sites [chemical binding]; other site
1036673014944	Q-X-W motif; other site
1036673014945	Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577
1036673014946	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
1036673014947	substrate binding site [chemical binding]; other site
1036673014948	multimerization interface [polypeptide binding]; other site
1036673014949	ATP binding site [chemical binding]; other site
1036673014950	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1036673014951	Cytochrome P450; Region: p450; cl12078
1036673014952	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673014953	MarR family; Region: MarR; pfam01047
1036673014954	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673014955	Coenzyme A binding pocket [chemical binding]; other site
1036673014956	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1036673014957	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1036673014958	SpoVR like protein; Region: SpoVR; pfam04293
1036673014959	Protein of unknown function (DUF444); Region: DUF444; cl17371
1036673014960	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
1036673014961	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1036673014962	Domain of unknown function (DUF4281); Region: DUF4281; pfam14108
1036673014963	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673014964	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673014965	PAS domain S-box; Region: sensory_box; TIGR00229
1036673014966	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673014967	putative active site [active]
1036673014968	heme pocket [chemical binding]; other site
1036673014969	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1036673014970	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673014971	putative active site [active]
1036673014972	heme pocket [chemical binding]; other site
1036673014973	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673014974	dimer interface [polypeptide binding]; other site
1036673014975	phosphorylation site [posttranslational modification]
1036673014976	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673014977	ATP binding site [chemical binding]; other site
1036673014978	Mg2+ binding site [ion binding]; other site
1036673014979	G-X-G motif; other site
1036673014980	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673014981	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673014982	active site
1036673014983	phosphorylation site [posttranslational modification]
1036673014984	intermolecular recognition site; other site
1036673014985	dimerization interface [polypeptide binding]; other site
1036673014986	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1036673014987	nudix motif; other site
1036673014988	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
1036673014989	putative dimer interface [polypeptide binding]; other site
1036673014990	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673014991	ligand binding site [chemical binding]; other site
1036673014992	Zn binding site [ion binding]; other site
1036673014993	SWIM zinc finger; Region: SWIM; pfam04434
1036673014994	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
1036673014995	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1036673014996	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673014997	ATP binding site [chemical binding]; other site
1036673014998	putative Mg++ binding site [ion binding]; other site
1036673014999	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1036673015000	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673015001	nucleotide binding region [chemical binding]; other site
1036673015002	ATP-binding site [chemical binding]; other site
1036673015003	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
1036673015004	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1036673015005	metal ion-dependent adhesion site (MIDAS); other site
1036673015006	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1036673015007	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1036673015008	homodimer interface [polypeptide binding]; other site
1036673015009	substrate-cofactor binding pocket; other site
1036673015010	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673015011	catalytic residue [active]
1036673015012	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
1036673015013	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
1036673015014	Substrate-binding site [chemical binding]; other site
1036673015015	Substrate specificity [chemical binding]; other site
1036673015016	CHASE3 domain; Region: CHASE3; cl05000
1036673015017	CHASE3 domain; Region: CHASE3; pfam05227
1036673015018	PAS fold; Region: PAS_4; pfam08448
1036673015019	PAS domain S-box; Region: sensory_box; TIGR00229
1036673015020	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673015021	putative active site [active]
1036673015022	heme pocket [chemical binding]; other site
1036673015023	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673015024	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673015025	metal binding site [ion binding]; metal-binding site
1036673015026	active site
1036673015027	I-site; other site
1036673015028	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673015029	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1036673015030	catalytic triad [active]
1036673015031	conserved cis-peptide bond; other site
1036673015032	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1036673015033	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1036673015034	peptide binding site [polypeptide binding]; other site
1036673015035	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
1036673015036	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1036673015037	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1036673015038	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1036673015039	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1036673015040	Protein of unknown function (DUF3967); Region: DUF3967; pfam13152
1036673015041	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
1036673015042	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1036673015043	Cytochrome P450; Region: p450; cl12078
1036673015044	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1036673015045	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1036673015046	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1036673015047	active site clefts [active]
1036673015048	zinc binding site [ion binding]; other site
1036673015049	dimer interface [polypeptide binding]; other site
1036673015050	Isochorismatase family; Region: Isochorismatase; pfam00857
1036673015051	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1036673015052	catalytic triad [active]
1036673015053	conserved cis-peptide bond; other site
1036673015054	GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451
1036673015055	GIY-YIG motif/motif A; other site
1036673015056	Pectic acid lyase; Region: Pec_lyase; pfam09492
1036673015057	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1036673015058	hypothetical protein; Provisional; Region: PRK13660
1036673015059	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1036673015060	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1036673015061	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1036673015062	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1036673015063	Haemolysin-type calcium binding protein related domain; Region: HCBP_related; pfam06594
1036673015064	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1036673015065	putative transporter; Provisional; Region: PRK11021
1036673015066	Biofilm formation and stress response factor; Region: BsmA; cl01794
1036673015067	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
1036673015068	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
1036673015069	G1 box; other site
1036673015070	putative GEF interaction site [polypeptide binding]; other site
1036673015071	GTP/Mg2+ binding site [chemical binding]; other site
1036673015072	Switch I region; other site
1036673015073	G2 box; other site
1036673015074	G3 box; other site
1036673015075	Switch II region; other site
1036673015076	G4 box; other site
1036673015077	G5 box; other site
1036673015078	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1036673015079	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
1036673015080	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
1036673015081	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1036673015082	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1036673015083	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1036673015084	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
1036673015085	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1036673015086	putative active site [active]
1036673015087	putative metal binding site [ion binding]; other site
1036673015088	multidrug efflux protein; Reviewed; Region: PRK01766
1036673015089	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1036673015090	cation binding site [ion binding]; other site
1036673015091	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
1036673015092	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673015093	Interdomain contacts; other site
1036673015094	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cd00598
1036673015095	active site
1036673015096	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1036673015097	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1036673015098	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673015099	non-specific DNA binding site [nucleotide binding]; other site
1036673015100	salt bridge; other site
1036673015101	sequence-specific DNA binding site [nucleotide binding]; other site
1036673015102	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1036673015103	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1036673015104	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015105	dimer interface [polypeptide binding]; other site
1036673015106	conserved gate region; other site
1036673015107	putative PBP binding loops; other site
1036673015108	ABC-ATPase subunit interface; other site
1036673015109	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1036673015110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015111	dimer interface [polypeptide binding]; other site
1036673015112	conserved gate region; other site
1036673015113	putative PBP binding loops; other site
1036673015114	ABC-ATPase subunit interface; other site
1036673015115	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1036673015116	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
1036673015117	peptide binding site [polypeptide binding]; other site
1036673015118	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1036673015119	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673015120	Walker A/P-loop; other site
1036673015121	ATP binding site [chemical binding]; other site
1036673015122	Q-loop/lid; other site
1036673015123	ABC transporter signature motif; other site
1036673015124	Walker B; other site
1036673015125	D-loop; other site
1036673015126	H-loop/switch region; other site
1036673015127	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1036673015128	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1036673015129	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673015130	Walker A/P-loop; other site
1036673015131	ATP binding site [chemical binding]; other site
1036673015132	Q-loop/lid; other site
1036673015133	ABC transporter signature motif; other site
1036673015134	Walker B; other site
1036673015135	D-loop; other site
1036673015136	H-loop/switch region; other site
1036673015137	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1036673015138	Phytase; Region: Phytase; cl17685
1036673015139	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
1036673015140	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
1036673015141	NodB motif; other site
1036673015142	active site
1036673015143	catalytic site [active]
1036673015144	Cd binding site [ion binding]; other site
1036673015145	Predicted ATPase [General function prediction only]; Region: COG3910
1036673015146	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673015147	Walker A/P-loop; other site
1036673015148	ATP binding site [chemical binding]; other site
1036673015149	Q-loop/lid; other site
1036673015150	ABC transporter signature motif; other site
1036673015151	Walker B; other site
1036673015152	D-loop; other site
1036673015153	H-loop/switch region; other site
1036673015154	Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184
1036673015155	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673015156	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673015157	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673015158	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673015159	dimer interface [polypeptide binding]; other site
1036673015160	phosphorylation site [posttranslational modification]
1036673015161	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673015162	ATP binding site [chemical binding]; other site
1036673015163	Mg2+ binding site [ion binding]; other site
1036673015164	G-X-G motif; other site
1036673015165	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1036673015166	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1036673015167	Walker A/P-loop; other site
1036673015168	ATP binding site [chemical binding]; other site
1036673015169	Q-loop/lid; other site
1036673015170	ABC transporter signature motif; other site
1036673015171	Walker B; other site
1036673015172	D-loop; other site
1036673015173	H-loop/switch region; other site
1036673015174	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1036673015175	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1036673015176	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673015177	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673015178	active site
1036673015179	catalytic tetrad [active]
1036673015180	metal-dependent hydrolase; Provisional; Region: PRK13291
1036673015181	DinB superfamily; Region: DinB_2; pfam12867
1036673015182	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
1036673015183	hydrophobic ligand binding site; other site
1036673015184	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673015185	dimerization interface [polypeptide binding]; other site
1036673015186	putative DNA binding site [nucleotide binding]; other site
1036673015187	putative Zn2+ binding site [ion binding]; other site
1036673015188	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673015189	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1036673015190	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
1036673015191	putative FMN binding site [chemical binding]; other site
1036673015192	S-layer homology domain; Region: SLH; pfam00395
1036673015193	S-layer homology domain; Region: SLH; pfam00395
1036673015194	S-layer homology domain; Region: SLH; pfam00395
1036673015195	alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199
1036673015196	M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690
1036673015197	metal binding site [ion binding]; metal-binding site
1036673015198	Peptidase M14-like domain; uncharacterized subgroup; Region: M14-like_1_7; cd06244
1036673015199	putative active site [active]
1036673015200	Zn binding site [ion binding]; other site
1036673015201	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1036673015202	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1036673015203	Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed;  identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187
1036673015204	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
1036673015205	Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084
1036673015206	ligand binding site [chemical binding]; other site
1036673015207	metal binding site [ion binding]; metal-binding site
1036673015208	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1036673015209	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1036673015210	DNA binding residues [nucleotide binding]
1036673015211	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1036673015212	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1036673015213	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673015214	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673015215	DNA binding residues [nucleotide binding]
1036673015216	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
1036673015217	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1036673015218	TAP-like protein; Region: Abhydrolase_4; pfam08386
1036673015219	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
1036673015220	Uncharacterized conserved protein [Function unknown]; Region: COG3595
1036673015221	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
1036673015222	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673015223	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1036673015224	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1036673015225	Uncharacterized conserved protein [Function unknown]; Region: COG1683
1036673015226	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1036673015227	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673015228	ABC transporter; Region: ABC_tran_2; pfam12848
1036673015229	ABC-type transport system involved in cytochrome c biogenesis, ATPase component [Posttranslational modification, protein turnover, chaperones]; Region: CcmA; COG4133
1036673015230	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1036673015231	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1036673015232	CoenzymeA binding site [chemical binding]; other site
1036673015233	subunit interaction site [polypeptide binding]; other site
1036673015234	PHB binding site; other site
1036673015235	Predicted transcriptional regulator [Transcription]; Region: COG1959
1036673015236	Transcriptional regulator; Region: Rrf2; pfam02082
1036673015237	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1036673015238	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673015239	Interdomain contacts; other site
1036673015240	Cytokine receptor motif; other site
1036673015241	Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086
1036673015242	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673015243	TATA Binding Protein (TBP) Associated Factor 9 (TAF9) is one of several TAFs that bind TBP and is involved in forming Transcription Factor IID (TFIID) complex; Region: TAF9; cl17378
1036673015244	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673015245	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015246	dimer interface [polypeptide binding]; other site
1036673015247	conserved gate region; other site
1036673015248	putative PBP binding loops; other site
1036673015249	ABC-ATPase subunit interface; other site
1036673015250	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673015251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015252	dimer interface [polypeptide binding]; other site
1036673015253	conserved gate region; other site
1036673015254	putative PBP binding loops; other site
1036673015255	ABC-ATPase subunit interface; other site
1036673015256	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673015257	active site
1036673015258	phosphorylation site [posttranslational modification]
1036673015259	intermolecular recognition site; other site
1036673015260	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673015261	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673015262	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673015263	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1036673015264	Histidine kinase; Region: His_kinase; pfam06580
1036673015265	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1036673015266	ATP binding site [chemical binding]; other site
1036673015267	Mg2+ binding site [ion binding]; other site
1036673015268	G-X-G motif; other site
1036673015269	CAAX protease self-immunity; Region: Abi; pfam02517
1036673015270	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673015271	Interdomain contacts; other site
1036673015272	Cytokine receptor motif; other site
1036673015273	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1036673015274	dockerin binding interface; other site
1036673015275	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1036673015276	pentamer interface [polypeptide binding]; other site
1036673015277	dodecaamer interface [polypeptide binding]; other site
1036673015278	YvbH-like oligomerisation region; Region: YvbH_ext; pfam11724
1036673015279	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673015280	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673015281	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
1036673015282	substrate binding site [chemical binding]; other site
1036673015283	catalytic residues [active]
1036673015284	S-layer homology domain; Region: SLH; pfam00395
1036673015285	S-layer homology domain; Region: SLH; pfam00395
1036673015286	S-layer homology domain; Region: SLH; pfam00395
1036673015287	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1036673015288	Cytochrome P450; Region: p450; cl12078
1036673015289	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1036673015290	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1036673015291	DNA interaction; other site
1036673015292	Metal-binding active site; metal-binding site
1036673015293	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673015294	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015295	dimer interface [polypeptide binding]; other site
1036673015296	conserved gate region; other site
1036673015297	putative PBP binding loops; other site
1036673015298	ABC-ATPase subunit interface; other site
1036673015299	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673015300	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015301	dimer interface [polypeptide binding]; other site
1036673015302	conserved gate region; other site
1036673015303	ABC-ATPase subunit interface; other site
1036673015304	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673015305	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1036673015306	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673015307	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673015308	Coat F domain; Region: Coat_F; cl17715
1036673015309	Protein of unknown function (DUF4025); Region: DUF4025; pfam13217
1036673015310	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
1036673015311	X25 domain of Bacillus acidopullulyticus pullulanase and similar proteins; Region: X25_BaPul_like; cd12962
1036673015312	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1036673015313	homodimer interface [polypeptide binding]; other site
1036673015314	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1036673015315	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1036673015316	active site
1036673015317	homodimer interface [polypeptide binding]; other site
1036673015318	catalytic site [active]
1036673015319	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673015320	Interdomain contacts; other site
1036673015321	Cytokine receptor motif; other site
1036673015322	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1036673015323	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1036673015324	S-layer homology domain; Region: SLH; pfam00395
1036673015325	S-layer homology domain; Region: SLH; pfam00395
1036673015326	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673015327	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673015328	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673015329	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1036673015330	Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954
1036673015331	LigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: LigD_Pol_like; cd04861
1036673015332	nucleotide binding site [chemical binding]; other site
1036673015333	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1036673015334	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
1036673015335	active site
1036673015336	DNA binding site [nucleotide binding]
1036673015337	The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424
1036673015338	DNA binding site [nucleotide binding]
1036673015339	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1036673015340	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1036673015341	putative DNA binding site [nucleotide binding]; other site
1036673015342	putative homodimer interface [polypeptide binding]; other site
1036673015343	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673015344	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673015345	active site
1036673015346	catalytic tetrad [active]
1036673015347	Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773
1036673015348	Protein of unknown function, DUF393; Region: DUF393; pfam04134
1036673015349	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
1036673015350	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1036673015351	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673015352	dimerization interface [polypeptide binding]; other site
1036673015353	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673015354	dimerization interface [polypeptide binding]; other site
1036673015355	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1036673015356	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673015357	dimerization interface [polypeptide binding]; other site
1036673015358	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673015359	dimerization interface [polypeptide binding]; other site
1036673015360	FOG: HAMP domain [Signal transduction mechanisms]; Region: ResE; COG2770
1036673015361	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1036673015362	dimerization interface [polypeptide binding]; other site
1036673015363	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673015364	dimerization interface [polypeptide binding]; other site
1036673015365	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673015366	dimerization interface [polypeptide binding]; other site
1036673015367	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673015368	dimerization interface [polypeptide binding]; other site
1036673015369	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673015370	dimerization interface [polypeptide binding]; other site
1036673015371	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1036673015372	GAF domain; Region: GAF; pfam01590
1036673015373	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673015374	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1036673015375	dimer interface [polypeptide binding]; other site
1036673015376	phosphorylation site [posttranslational modification]
1036673015377	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673015378	ATP binding site [chemical binding]; other site
1036673015379	Mg2+ binding site [ion binding]; other site
1036673015380	G-X-G motif; other site
1036673015381	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673015382	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673015383	active site
1036673015384	phosphorylation site [posttranslational modification]
1036673015385	intermolecular recognition site; other site
1036673015386	dimerization interface [polypeptide binding]; other site
1036673015387	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673015388	active site
1036673015389	phosphorylation site [posttranslational modification]
1036673015390	intermolecular recognition site; other site
1036673015391	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1036673015392	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673015393	active site
1036673015394	phosphorylation site [posttranslational modification]
1036673015395	intermolecular recognition site; other site
1036673015396	dimerization interface [polypeptide binding]; other site
1036673015397	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1036673015398	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1036673015399	dimer interface [polypeptide binding]; other site
1036673015400	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673015401	catalytic residue [active]
1036673015402	Cache domain; Region: Cache_1; pfam02743
1036673015403	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673015404	dimerization interface [polypeptide binding]; other site
1036673015405	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673015406	dimer interface [polypeptide binding]; other site
1036673015407	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673015408	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673015409	dimer interface [polypeptide binding]; other site
1036673015410	putative CheW interface [polypeptide binding]; other site
1036673015411	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1036673015412	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1036673015413	active site
1036673015414	iron coordination sites [ion binding]; other site
1036673015415	substrate binding pocket [chemical binding]; other site
1036673015416	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1036673015417	Predicted membrane protein [Function unknown]; Region: COG2323
1036673015418	Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844
1036673015419	Spore germination protein; Region: Spore_permease; cl17796
1036673015420	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673015421	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673015422	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673015423	Protein of unknown function (DUF419); Region: DUF419; pfam04237
1036673015424	Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283
1036673015425	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1036673015426	NAD binding site [chemical binding]; other site
1036673015427	catalytic Zn binding site [ion binding]; other site
1036673015428	structural Zn binding site [ion binding]; other site
1036673015429	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
1036673015430	active site
1036673015431	DNA binding site [nucleotide binding]
1036673015432	Rhomboid family; Region: Rhomboid; pfam01694
1036673015433	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1036673015434	NlpC/P60 family; Region: NLPC_P60; pfam00877
1036673015435	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1036673015436	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
1036673015437	dimer interface [polypeptide binding]; other site
1036673015438	catalytic triad [active]
1036673015439	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1036673015440	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1036673015441	peptide binding site [polypeptide binding]; other site
1036673015442	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1036673015443	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673015444	Walker A/P-loop; other site
1036673015445	ATP binding site [chemical binding]; other site
1036673015446	Q-loop/lid; other site
1036673015447	ABC transporter signature motif; other site
1036673015448	Walker B; other site
1036673015449	D-loop; other site
1036673015450	H-loop/switch region; other site
1036673015451	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1036673015452	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1036673015453	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015454	dimer interface [polypeptide binding]; other site
1036673015455	conserved gate region; other site
1036673015456	putative PBP binding loops; other site
1036673015457	ABC-ATPase subunit interface; other site
1036673015458	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1036673015459	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015460	dimer interface [polypeptide binding]; other site
1036673015461	conserved gate region; other site
1036673015462	putative PBP binding loops; other site
1036673015463	ABC-ATPase subunit interface; other site
1036673015464	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_1; cd08663
1036673015465	SxDxEG motif; other site
1036673015466	active site
1036673015467	metal binding site [ion binding]; metal-binding site
1036673015468	homopentamer interface [polypeptide binding]; other site
1036673015469	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673015470	Interdomain contacts; other site
1036673015471	Cytokine receptor motif; other site
1036673015472	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673015473	Interdomain contacts; other site
1036673015474	Cytokine receptor motif; other site
1036673015475	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1036673015476	dockerin binding interface; other site
1036673015477	Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086
1036673015478	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1036673015479	metal binding site [ion binding]; metal-binding site
1036673015480	active site
1036673015481	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673015482	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673015483	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673015484	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015485	dimer interface [polypeptide binding]; other site
1036673015486	conserved gate region; other site
1036673015487	putative PBP binding loops; other site
1036673015488	ABC-ATPase subunit interface; other site
1036673015489	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673015490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015491	dimer interface [polypeptide binding]; other site
1036673015492	conserved gate region; other site
1036673015493	ABC-ATPase subunit interface; other site
1036673015494	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673015495	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673015496	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1036673015497	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1036673015498	active site
1036673015499	catalytic triad [active]
1036673015500	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1036673015501	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
1036673015502	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673015503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015504	dimer interface [polypeptide binding]; other site
1036673015505	conserved gate region; other site
1036673015506	putative PBP binding loops; other site
1036673015507	ABC-ATPase subunit interface; other site
1036673015508	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673015509	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015510	dimer interface [polypeptide binding]; other site
1036673015511	conserved gate region; other site
1036673015512	putative PBP binding loops; other site
1036673015513	ABC-ATPase subunit interface; other site
1036673015514	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1036673015515	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673015516	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673015517	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1036673015518	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673015519	active site
1036673015520	phosphorylation site [posttranslational modification]
1036673015521	intermolecular recognition site; other site
1036673015522	dimerization interface [polypeptide binding]; other site
1036673015523	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673015524	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673015525	HAMP domain; Region: HAMP; pfam00672
1036673015526	dimerization interface [polypeptide binding]; other site
1036673015527	Histidine kinase; Region: His_kinase; pfam06580
1036673015528	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673015529	ATP binding site [chemical binding]; other site
1036673015530	Mg2+ binding site [ion binding]; other site
1036673015531	G-X-G motif; other site
1036673015532	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673015533	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1036673015534	active site
1036673015535	motif I; other site
1036673015536	motif II; other site
1036673015537	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1036673015538	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1036673015539	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1036673015540	nudix motif; other site
1036673015541	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1036673015542	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673015543	Coenzyme A binding pocket [chemical binding]; other site
1036673015544	Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032
1036673015545	Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305
1036673015546	E-class dimer interface [polypeptide binding]; other site
1036673015547	P-class dimer interface [polypeptide binding]; other site
1036673015548	active site
1036673015549	Cu2+ binding site [ion binding]; other site
1036673015550	Zn2+ binding site [ion binding]; other site
1036673015551	Protein of unknown function (DUF4023); Region: DUF4023; pfam13215
1036673015552	hypothetical protein; Provisional; Region: PRK06753
1036673015553	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1036673015554	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1036673015555	Predicted membrane protein [Function unknown]; Region: COG2323
1036673015556	Protein of unknown function (DUF2809); Region: DUF2809; pfam10990
1036673015557	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1036673015558	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1036673015559	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1036673015560	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1036673015561	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; pfam00208
1036673015562	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
1036673015563	NAD binding site [chemical binding]; other site
1036673015564	Phe binding site; other site
1036673015565	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036673015566	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673015567	S-adenosylmethionine binding site [chemical binding]; other site
1036673015568	Predicted membrane protein [Function unknown]; Region: COG4129
1036673015569	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1036673015570	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1036673015571	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
1036673015572	Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787
1036673015573	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1036673015574	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036673015575	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036673015576	Walker A/P-loop; other site
1036673015577	ATP binding site [chemical binding]; other site
1036673015578	Q-loop/lid; other site
1036673015579	ABC transporter signature motif; other site
1036673015580	Walker B; other site
1036673015581	D-loop; other site
1036673015582	H-loop/switch region; other site
1036673015583	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
1036673015584	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016
1036673015585	dimer interface [polypeptide binding]; other site
1036673015586	active site
1036673015587	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673015588	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1036673015589	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1036673015590	active site
1036673015591	Isochorismatase family; Region: Isochorismatase; pfam00857
1036673015592	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1036673015593	catalytic triad [active]
1036673015594	conserved cis-peptide bond; other site
1036673015595	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
1036673015596	Part of AAA domain; Region: AAA_19; pfam13245
1036673015597	Family description; Region: UvrD_C_2; pfam13538
1036673015598	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1036673015599	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673015600	Coenzyme A binding pocket [chemical binding]; other site
1036673015601	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673015602	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673015603	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1036673015604	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1036673015605	Coenzyme A binding pocket [chemical binding]; other site
1036673015606	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1036673015607	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1036673015608	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036673015609	A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases.  Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417
1036673015610	type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846
1036673015611	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673015612	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673015613	Walker A/P-loop; other site
1036673015614	ATP binding site [chemical binding]; other site
1036673015615	Q-loop/lid; other site
1036673015616	ABC transporter signature motif; other site
1036673015617	Walker B; other site
1036673015618	D-loop; other site
1036673015619	H-loop/switch region; other site
1036673015620	Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase (HisA) and the cyclase subunit of imidazoleglycerol phosphate synthase (HisF). The ProFAR isomerase catalyzes the fourth step in histidine biosynthesis, an...; Region: HisA_HisF; cd04723
1036673015621	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1036673015622	active site
1036673015623	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1036673015624	Putative esterase; Region: Esterase; pfam00756
1036673015625	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1036673015626	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673015627	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673015628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673015629	active site
1036673015630	phosphorylation site [posttranslational modification]
1036673015631	intermolecular recognition site; other site
1036673015632	dimerization interface [polypeptide binding]; other site
1036673015633	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1036673015634	dimerization interface [polypeptide binding]; other site
1036673015635	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673015636	Histidine kinase; Region: His_kinase; pfam06580
1036673015637	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673015638	ATP binding site [chemical binding]; other site
1036673015639	Mg2+ binding site [ion binding]; other site
1036673015640	G-X-G motif; other site
1036673015641	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673015642	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673015643	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673015644	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015645	dimer interface [polypeptide binding]; other site
1036673015646	conserved gate region; other site
1036673015647	putative PBP binding loops; other site
1036673015648	ABC-ATPase subunit interface; other site
1036673015649	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673015650	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015651	dimer interface [polypeptide binding]; other site
1036673015652	conserved gate region; other site
1036673015653	ABC-ATPase subunit interface; other site
1036673015654	Protein of unknown function (DUF2536); Region: DUF2536; pfam10750
1036673015655	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1036673015656	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673015657	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673015658	dimer interface [polypeptide binding]; other site
1036673015659	phosphorylation site [posttranslational modification]
1036673015660	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673015661	ATP binding site [chemical binding]; other site
1036673015662	Mg2+ binding site [ion binding]; other site
1036673015663	G-X-G motif; other site
1036673015664	VanZ like family; Region: VanZ; pfam04892
1036673015665	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673015666	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673015667	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673015668	Spore germination protein; Region: Spore_permease; cl17796
1036673015669	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1036673015670	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1036673015671	putative active site [active]
1036673015672	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1036673015673	dimer interface [polypeptide binding]; other site
1036673015674	active site
1036673015675	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1036673015676	active site
1036673015677	homotetramer interface [polypeptide binding]; other site
1036673015678	homodimer interface [polypeptide binding]; other site
1036673015679	fructoselysine 3-epimerase; Provisional; Region: PRK09856
1036673015680	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1036673015681	Metal-binding active site; metal-binding site
1036673015682	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673015683	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015684	dimer interface [polypeptide binding]; other site
1036673015685	conserved gate region; other site
1036673015686	putative PBP binding loops; other site
1036673015687	ABC-ATPase subunit interface; other site
1036673015688	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673015689	dimer interface [polypeptide binding]; other site
1036673015690	conserved gate region; other site
1036673015691	putative PBP binding loops; other site
1036673015692	ABC-ATPase subunit interface; other site
1036673015693	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673015694	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673015695	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1036673015696	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1036673015697	substrate binding site [chemical binding]; other site
1036673015698	ATP binding site [chemical binding]; other site
1036673015699	DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402
1036673015700	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673015701	DNA-binding site [nucleotide binding]; DNA binding site
1036673015702	UTRA domain; Region: UTRA; pfam07702
1036673015703	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1036673015704	regulatory protein interface [polypeptide binding]; other site
1036673015705	regulatory phosphorylation site [posttranslational modification]; other site
1036673015706	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673015707	ATP binding site [chemical binding]; other site
1036673015708	putative Mg++ binding site [ion binding]; other site
1036673015709	nucleotide binding region [chemical binding]; other site
1036673015710	Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271
1036673015711	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
1036673015712	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
1036673015713	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1036673015714	Chromate transporter; Region: Chromate_transp; pfam02417
1036673015715	Chromate transporter; Region: Chromate_transp; pfam02417
1036673015716	YmaF family; Region: YmaF; pfam12788
1036673015717	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
1036673015718	YtkA-like; Region: YtkA; pfam13115
1036673015719	Family description; Region: DsbD_2; pfam13386
1036673015720	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1036673015721	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1036673015722	metal-binding site [ion binding]
1036673015723	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1036673015724	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1036673015725	nickel responsive regulator; Provisional; Region: PRK04460
1036673015726	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
1036673015727	NikR C terminal nickel binding domain; Region: NikR_C; pfam08753
1036673015728	Predicted membrane protein [Function unknown]; Region: COG4550
1036673015729	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
1036673015730	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1036673015731	Predicted permease; Region: DUF318; cl17795
1036673015732	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673015733	FeS/SAM binding site; other site
1036673015734	TRAM domain; Region: TRAM; pfam01938
1036673015735	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
1036673015736	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1036673015737	Propanediol utilisation protein PduL; Region: PduL; pfam06130
1036673015738	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
1036673015739	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
1036673015740	TPP-binding site [chemical binding]; other site
1036673015741	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
1036673015742	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
1036673015743	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1036673015744	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1036673015745	dimer interface [polypeptide binding]; other site
1036673015746	PYR/PP interface [polypeptide binding]; other site
1036673015747	TPP binding site [chemical binding]; other site
1036673015748	substrate binding site [chemical binding]; other site
1036673015749	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1036673015750	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1036673015751	active site
1036673015752	dimer interface [polypeptide binding]; other site
1036673015753	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
1036673015754	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1036673015755	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673015756	putative active site [active]
1036673015757	metal binding site [ion binding]; metal-binding site
1036673015758	homodimer binding site [polypeptide binding]; other site
1036673015759	phosphodiesterase; Provisional; Region: PRK12704
1036673015760	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036673015761	Zn2+ binding site [ion binding]; other site
1036673015762	Mg2+ binding site [ion binding]; other site
1036673015763	RecX family; Region: RecX; cl00936
1036673015764	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1036673015765	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1036673015766	Walker A motif; other site
1036673015767	ATP binding site [chemical binding]; other site
1036673015768	hexamer interface [polypeptide binding]; other site
1036673015769	Walker B motif; other site
1036673015770	competence damage-inducible protein A; Provisional; Region: PRK00549
1036673015771	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1036673015772	putative MPT binding site; other site
1036673015773	Competence-damaged protein; Region: CinA; pfam02464
1036673015774	CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Region: pgsA; TIGR00560
1036673015775	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
1036673015776	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1036673015777	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673015778	FeS/SAM binding site; other site
1036673015779	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
1036673015780	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
1036673015781	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1036673015782	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673015783	non-specific DNA binding site [nucleotide binding]; other site
1036673015784	salt bridge; other site
1036673015785	sequence-specific DNA binding site [nucleotide binding]; other site
1036673015786	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1036673015787	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1036673015788	Protein of unknown function (DUF3388); Region: DUF3388; pfam11868
1036673015789	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
1036673015790	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1036673015791	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673015792	NAD(P) binding site [chemical binding]; other site
1036673015793	active site
1036673015794	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1036673015795	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1036673015796	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1036673015797	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1036673015798	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1036673015799	PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582
1036673015800	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
1036673015801	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1036673015802	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1036673015803	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1036673015804	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1036673015805	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1036673015806	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1036673015807	YlzJ-like protein; Region: YlzJ; pfam14035
1036673015808	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
1036673015809	active site
1036673015810	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1036673015811	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036673015812	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1036673015813	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1036673015814	dihydrodipicolinate synthase; Region: dapA; TIGR00674
1036673015815	dimer interface [polypeptide binding]; other site
1036673015816	active site
1036673015817	catalytic residue [active]
1036673015818	aspartate kinase I; Reviewed; Region: PRK08210
1036673015819	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
1036673015820	nucleotide binding site [chemical binding]; other site
1036673015821	substrate binding site [chemical binding]; other site
1036673015822	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
1036673015823	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1036673015824	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1036673015825	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1036673015826	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
1036673015827	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
1036673015828	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
1036673015829	NAD binding site [chemical binding]; other site
1036673015830	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1036673015831	trimer interface [polypeptide binding]; other site
1036673015832	active site
1036673015833	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1036673015834	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1036673015835	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1036673015836	probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873
1036673015837	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
1036673015838	NodB motif; other site
1036673015839	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1036673015840	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1036673015841	RNase E interface [polypeptide binding]; other site
1036673015842	trimer interface [polypeptide binding]; other site
1036673015843	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1036673015844	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1036673015845	RNase E interface [polypeptide binding]; other site
1036673015846	trimer interface [polypeptide binding]; other site
1036673015847	active site
1036673015848	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1036673015849	putative nucleic acid binding region [nucleotide binding]; other site
1036673015850	G-X-X-G motif; other site
1036673015851	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1036673015852	RNA binding site [nucleotide binding]; other site
1036673015853	domain interface; other site
1036673015854	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1036673015855	16S/18S rRNA binding site [nucleotide binding]; other site
1036673015856	S13e-L30e interaction site [polypeptide binding]; other site
1036673015857	25S rRNA binding site [nucleotide binding]; other site
1036673015858	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1036673015859	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1036673015860	active site
1036673015861	Riboflavin kinase; Region: Flavokinase; pfam01687
1036673015862	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
1036673015863	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1036673015864	RNA binding site [nucleotide binding]; other site
1036673015865	active site
1036673015866	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
1036673015867	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1036673015868	DHH family; Region: DHH; pfam01368
1036673015869	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1036673015870	translation initiation factor IF-2; Validated; Region: infB; PRK05306
1036673015871	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1036673015872	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1036673015873	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1036673015874	G1 box; other site
1036673015875	putative GEF interaction site [polypeptide binding]; other site
1036673015876	GTP/Mg2+ binding site [chemical binding]; other site
1036673015877	Switch I region; other site
1036673015878	G2 box; other site
1036673015879	G3 box; other site
1036673015880	Switch II region; other site
1036673015881	G4 box; other site
1036673015882	G5 box; other site
1036673015883	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1036673015884	Translation-initiation factor 2; Region: IF-2; pfam11987
1036673015885	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1036673015886	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1036673015887	Protein of unknown function (DUF448); Region: DUF448; pfam04296
1036673015888	putative RNA binding cleft [nucleotide binding]; other site
1036673015889	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1036673015890	NusA N-terminal domain; Region: NusA_N; pfam08529
1036673015891	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1036673015892	RNA binding site [nucleotide binding]; other site
1036673015893	homodimer interface [polypeptide binding]; other site
1036673015894	NusA-like KH domain; Region: KH_5; pfam13184
1036673015895	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1036673015896	G-X-X-G motif; other site
1036673015897	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1036673015898	Sm and related proteins; Region: Sm_like; cl00259
1036673015899	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1036673015900	putative oligomer interface [polypeptide binding]; other site
1036673015901	putative RNA binding site [nucleotide binding]; other site
1036673015902	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1036673015903	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1036673015904	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1036673015905	generic binding surface I; other site
1036673015906	generic binding surface II; other site
1036673015907	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1036673015908	active site
1036673015909	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1036673015910	active site
1036673015911	catalytic site [active]
1036673015912	substrate binding site [chemical binding]; other site
1036673015913	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1036673015914	prolyl-tRNA synthetase; Provisional; Region: PRK08661
1036673015915	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
1036673015916	dimer interface [polypeptide binding]; other site
1036673015917	motif 1; other site
1036673015918	active site
1036673015919	motif 2; other site
1036673015920	motif 3; other site
1036673015921	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
1036673015922	anticodon binding site; other site
1036673015923	zinc-binding site [ion binding]; other site
1036673015924	RIP metalloprotease RseP; Region: TIGR00054
1036673015925	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1036673015926	active site
1036673015927	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1036673015928	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1036673015929	protein binding site [polypeptide binding]; other site
1036673015930	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1036673015931	putative substrate binding region [chemical binding]; other site
1036673015932	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1036673015933	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1036673015934	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1036673015935	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1036673015936	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1036673015937	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1036673015938	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14830
1036673015939	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1036673015940	catalytic residue [active]
1036673015941	putative FPP diphosphate  binding site; other site
1036673015942	putative FPP binding hydrophobic cleft; other site
1036673015943	dimer interface [polypeptide binding]; other site
1036673015944	putative IPP diphosphate binding site; other site
1036673015945	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1036673015946	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1036673015947	hinge region; other site
1036673015948	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1036673015949	putative nucleotide binding site [chemical binding]; other site
1036673015950	uridine monophosphate binding site [chemical binding]; other site
1036673015951	homohexameric interface [polypeptide binding]; other site
1036673015952	elongation factor Ts; Reviewed; Region: tsf; PRK12332
1036673015953	UBA/TS-N domain; Region: UBA; pfam00627
1036673015954	Elongation factor TS; Region: EF_TS; pfam00889
1036673015955	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1036673015956	rRNA interaction site [nucleotide binding]; other site
1036673015957	S8 interaction site; other site
1036673015958	putative laminin-1 binding site; other site
1036673015959	YceG-like family; Region: YceG; pfam02618
1036673015960	Protein of unknown function (DUF342); Region: DUF342; pfam03961
1036673015961	RNA polymerase sigma factor SigD; Validated; Region: PRK07670
1036673015962	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673015963	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1036673015964	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673015965	DNA binding residues [nucleotide binding]
1036673015966	heterogeneous nuclear ribonucleoprotein R, Q family; Region: hnRNP-R-Q; TIGR01648
1036673015967	Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871
1036673015968	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
1036673015969	CheC-like family; Region: CheC; pfam04509
1036673015970	CheC-like family; Region: CheC; pfam04509
1036673015971	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1036673015972	putative CheA interaction surface; other site
1036673015973	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1036673015974	putative binding surface; other site
1036673015975	active site
1036673015976	P2 response regulator binding domain; Region: P2; pfam07194
1036673015977	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1036673015978	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1036673015979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673015980	ATP binding site [chemical binding]; other site
1036673015981	Mg2+ binding site [ion binding]; other site
1036673015982	G-X-G motif; other site
1036673015983	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1036673015984	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
1036673015985	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673015986	active site
1036673015987	phosphorylation site [posttranslational modification]
1036673015988	intermolecular recognition site; other site
1036673015989	dimerization interface [polypeptide binding]; other site
1036673015990	CheB methylesterase; Region: CheB_methylest; pfam01339
1036673015991	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
1036673015992	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
1036673015993	P-loop; other site
1036673015994	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
1036673015995	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1036673015996	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1036673015997	FHIPEP family; Region: FHIPEP; pfam00771
1036673015998	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1036673015999	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1036673016000	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1036673016001	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
1036673016002	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1036673016003	Flagellar biosynthesis protein, FliO; Region: FliO; cl01247
1036673016004	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673016005	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673016006	active site
1036673016007	phosphorylation site [posttranslational modification]
1036673016008	intermolecular recognition site; other site
1036673016009	dimerization interface [polypeptide binding]; other site
1036673016010	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
1036673016011	CheC-like family; Region: CheC; pfam04509
1036673016012	CheC-like family; Region: CheC; pfam04509
1036673016013	flagellar motor switch protein FliN; Region: fliN; TIGR02480
1036673016014	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
1036673016015	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1036673016016	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718
1036673016017	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
1036673016018	Flagellar protein (FlbD); Region: FlbD; pfam06289
1036673016019	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
1036673016020	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1036673016021	Class I aldolases; Region: Aldolase_Class_I; cl17187
1036673016022	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1036673016023	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
1036673016024	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1036673016025	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1036673016026	Uncharacterized conserved protein [Function unknown]; Region: COG3334
1036673016027	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720
1036673016028	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
1036673016029	flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721
1036673016030	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1036673016031	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
1036673016032	Walker A motif/ATP binding site; other site
1036673016033	Walker B motif; other site
1036673016034	flagellar assembly protein FliH; Region: FliH_bacil; TIGR03825
1036673016035	Flagellar assembly protein FliH; Region: FliH; pfam02108
1036673016036	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
1036673016037	FliG C-terminal domain; Region: FliG_C; pfam01706
1036673016038	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1036673016039	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
1036673016040	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1036673016041	Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139
1036673016042	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
1036673016043	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1036673016044	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1036673016045	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
1036673016046	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
1036673016047	transcriptional repressor CodY; Validated; Region: PRK04158
1036673016048	CodY GAF-like domain; Region: CodY; pfam06018
1036673016049	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
1036673016050	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1036673016051	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
1036673016052	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673016053	Walker A motif; other site
1036673016054	ATP binding site [chemical binding]; other site
1036673016055	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1036673016056	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1036673016057	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1036673016058	active site
1036673016059	HslU subunit interaction site [polypeptide binding]; other site
1036673016060	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1036673016061	Glucose inhibited division protein A; Region: GIDA; pfam01134
1036673016062	DNA topoisomerase I; Validated; Region: PRK05582
1036673016063	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1036673016064	active site
1036673016065	interdomain interaction site; other site
1036673016066	putative metal-binding site [ion binding]; other site
1036673016067	nucleotide binding site [chemical binding]; other site
1036673016068	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1036673016069	domain I; other site
1036673016070	DNA binding groove [nucleotide binding]
1036673016071	phosphate binding site [ion binding]; other site
1036673016072	domain II; other site
1036673016073	domain III; other site
1036673016074	nucleotide binding site [chemical binding]; other site
1036673016075	catalytic site [active]
1036673016076	domain IV; other site
1036673016077	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1036673016078	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1036673016079	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1036673016080	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1036673016081	DNA protecting protein DprA; Region: dprA; TIGR00732
1036673016082	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1036673016083	CoA binding domain; Region: CoA_binding; smart00881
1036673016084	CoA-ligase; Region: Ligase_CoA; pfam00549
1036673016085	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1036673016086	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1036673016087	CoA-ligase; Region: Ligase_CoA; pfam00549
1036673016088	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1036673016089	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1036673016090	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673016091	Walker A motif; other site
1036673016092	ATP binding site [chemical binding]; other site
1036673016093	Walker B motif; other site
1036673016094	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1036673016095	hypothetical protein; Reviewed; Region: PRK12497
1036673016096	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
1036673016097	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1036673016098	RNA/DNA hybrid binding site [nucleotide binding]; other site
1036673016099	active site
1036673016100	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1036673016101	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1036673016102	putative active site [active]
1036673016103	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
1036673016104	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1036673016105	GTP/Mg2+ binding site [chemical binding]; other site
1036673016106	G4 box; other site
1036673016107	G5 box; other site
1036673016108	G1 box; other site
1036673016109	Switch I region; other site
1036673016110	G2 box; other site
1036673016111	G3 box; other site
1036673016112	Switch II region; other site
1036673016113	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1036673016114	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1036673016115	Catalytic site [active]
1036673016116	conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838
1036673016117	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1036673016118	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457
1036673016119	CARDB; Region: CARDB; pfam07705
1036673016120	S-layer homology domain; Region: SLH; pfam00395
1036673016121	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1036673016122	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1036673016123	RimM N-terminal domain; Region: RimM; pfam01782
1036673016124	PRC-barrel domain; Region: PRC; pfam05239
1036673016125	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1036673016126	hypothetical protein; Provisional; Region: PRK00468
1036673016127	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1036673016128	signal recognition particle protein; Provisional; Region: PRK10867
1036673016129	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1036673016130	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1036673016131	P loop; other site
1036673016132	GTP binding site [chemical binding]; other site
1036673016133	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1036673016134	putative DNA-binding protein; Validated; Region: PRK00118
1036673016135	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1036673016136	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1036673016137	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1036673016138	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1036673016139	P loop; other site
1036673016140	GTP binding site [chemical binding]; other site
1036673016141	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1036673016142	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1036673016143	Walker A/P-loop; other site
1036673016144	ATP binding site [chemical binding]; other site
1036673016145	Q-loop/lid; other site
1036673016146	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1036673016147	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1036673016148	ABC transporter signature motif; other site
1036673016149	Walker B; other site
1036673016150	D-loop; other site
1036673016151	H-loop/switch region; other site
1036673016152	ribonuclease III; Reviewed; Region: rnc; PRK00102
1036673016153	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1036673016154	dimerization interface [polypeptide binding]; other site
1036673016155	active site
1036673016156	metal binding site [ion binding]; metal-binding site
1036673016157	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1036673016158	dsRNA binding site [nucleotide binding]; other site
1036673016159	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1036673016160	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1036673016161	dimer interface [polypeptide binding]; other site
1036673016162	active site
1036673016163	acyl carrier protein; Provisional; Region: acpP; PRK00982
1036673016164	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1036673016165	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1036673016166	NAD(P) binding site [chemical binding]; other site
1036673016167	homotetramer interface [polypeptide binding]; other site
1036673016168	homodimer interface [polypeptide binding]; other site
1036673016169	active site
1036673016170	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1036673016171	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1036673016172	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1036673016173	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1036673016174	dimer interface [polypeptide binding]; other site
1036673016175	active site
1036673016176	CoA binding pocket [chemical binding]; other site
1036673016177	putative phosphate acyltransferase; Provisional; Region: PRK05331
1036673016178	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
1036673016179	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1036673016180	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1036673016181	active site 2 [active]
1036673016182	active site 1 [active]
1036673016183	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
1036673016184	hypothetical protein; Provisional; Region: PRK13670
1036673016185	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
1036673016186	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1036673016187	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1036673016188	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1036673016189	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
1036673016190	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1036673016191	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1036673016192	active site
1036673016193	(T/H)XGH motif; other site
1036673016194	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1036673016195	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673016196	S-adenosylmethionine binding site [chemical binding]; other site
1036673016197	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1036673016198	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1036673016199	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1036673016200	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1036673016201	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673016202	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1036673016203	Glycosyl hydrolase family 43; Region: GH43_4; cd08983
1036673016204	active site
1036673016205	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
1036673016206	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
1036673016207	RDD family; Region: RDD; pfam06271
1036673016208	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
1036673016209	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673016210	putative metal binding site [ion binding]; other site
1036673016211	Predicted membrane protein [Function unknown]; Region: COG3766
1036673016212	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1036673016213	Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503
1036673016214	Glucuronate isomerase; Region: UxaC; pfam02614
1036673016215	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
1036673016216	DNA polymerase IV; Reviewed; Region: PRK03103
1036673016217	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1036673016218	active site
1036673016219	DNA binding site [nucleotide binding]
1036673016220	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
1036673016221	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1036673016222	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1036673016223	Right handed beta helix region; Region: Beta_helix; pfam13229
1036673016224	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036673016225	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673016226	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673016227	Stage VI sporulation protein F; Region: SpoVIF; pfam14069
1036673016228	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1036673016229	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1036673016230	generic binding surface II; other site
1036673016231	ssDNA binding site; other site
1036673016232	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673016233	ATP binding site [chemical binding]; other site
1036673016234	putative Mg++ binding site [ion binding]; other site
1036673016235	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673016236	nucleotide binding region [chemical binding]; other site
1036673016237	ATP-binding site [chemical binding]; other site
1036673016238	EDD domain protein, DegV family; Region: DegV; TIGR00762
1036673016239	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1036673016240	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1036673016241	DAK2 domain; Region: Dak2; pfam02734
1036673016242	Asp23 family; Region: Asp23; pfam03780
1036673016243	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1036673016244	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1036673016245	substrate binding site [chemical binding]; other site
1036673016246	hexamer interface [polypeptide binding]; other site
1036673016247	metal binding site [ion binding]; metal-binding site
1036673016248	GTPase RsgA; Reviewed; Region: PRK00098
1036673016249	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1036673016250	RNA binding site [nucleotide binding]; other site
1036673016251	homodimer interface [polypeptide binding]; other site
1036673016252	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1036673016253	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1036673016254	GTP/Mg2+ binding site [chemical binding]; other site
1036673016255	G4 box; other site
1036673016256	G5 box; other site
1036673016257	G1 box; other site
1036673016258	Switch I region; other site
1036673016259	G2 box; other site
1036673016260	G3 box; other site
1036673016261	Switch II region; other site
1036673016262	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1036673016263	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1036673016264	active site
1036673016265	ATP binding site [chemical binding]; other site
1036673016266	substrate binding site [chemical binding]; other site
1036673016267	activation loop (A-loop); other site
1036673016268	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1036673016269	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
1036673016270	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1036673016271	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1036673016272	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1036673016273	active site
1036673016274	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1036673016275	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673016276	FeS/SAM binding site; other site
1036673016277	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1036673016278	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
1036673016279	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673016280	S-adenosylmethionine binding site [chemical binding]; other site
1036673016281	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1036673016282	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1036673016283	putative active site [active]
1036673016284	substrate binding site [chemical binding]; other site
1036673016285	putative cosubstrate binding site; other site
1036673016286	catalytic site [active]
1036673016287	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1036673016288	substrate binding site [chemical binding]; other site
1036673016289	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1036673016290	active site
1036673016291	catalytic residues [active]
1036673016292	metal binding site [ion binding]; metal-binding site
1036673016293	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673016294	primosomal protein N' Region: priA; TIGR00595
1036673016295	ATP binding site [chemical binding]; other site
1036673016296	putative Mg++ binding site [ion binding]; other site
1036673016297	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1036673016298	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1036673016299	Flavoprotein; Region: Flavoprotein; pfam02441
1036673016300	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1036673016301	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1036673016302	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1036673016303	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1036673016304	catalytic site [active]
1036673016305	G-X2-G-X-G-K; other site
1036673016306	hypothetical protein; Provisional; Region: PRK04323
1036673016307	hypothetical protein; Provisional; Region: PRK11820
1036673016308	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1036673016309	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1036673016310	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
1036673016311	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
1036673016312	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1036673016313	FAD binding site [chemical binding]; other site
1036673016314	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1036673016315	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1036673016316	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1036673016317	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1036673016318	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1036673016319	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1036673016320	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1036673016321	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673016322	motif II; other site
1036673016323	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1036673016324	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1036673016325	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1036673016326	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1036673016327	Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104
1036673016328	DNA binding residues [nucleotide binding]
1036673016329	B12 binding domain; Region: B12-binding_2; pfam02607
1036673016330	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
1036673016331	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
1036673016332	CheB methylesterase; Region: CheB_methylest; pfam01339
1036673016333	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1036673016334	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1036673016335	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1036673016336	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473
1036673016337	PAS domain; Region: PAS_10; pfam13596
1036673016338	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1036673016339	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673016340	putative active site [active]
1036673016341	heme pocket [chemical binding]; other site
1036673016342	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673016343	dimer interface [polypeptide binding]; other site
1036673016344	phosphorylation site [posttranslational modification]
1036673016345	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673016346	ATP binding site [chemical binding]; other site
1036673016347	Mg2+ binding site [ion binding]; other site
1036673016348	G-X-G motif; other site
1036673016349	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1036673016350	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1036673016351	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1036673016352	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673016353	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673016354	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1036673016355	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1036673016356	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1036673016357	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1036673016358	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1036673016359	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1036673016360	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012
1036673016361	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673016362	Phosphotransferase enzyme family; Region: APH; pfam01636
1036673016363	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1036673016364	active site
1036673016365	substrate binding site [chemical binding]; other site
1036673016366	ATP binding site [chemical binding]; other site
1036673016367	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036673016368	MULE transposase domain; Region: MULE; pfam10551
1036673016369	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673016370	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673016371	short chain dehydrogenase; Provisional; Region: PRK06500
1036673016372	classical (c) SDRs; Region: SDR_c; cd05233
1036673016373	NAD(P) binding site [chemical binding]; other site
1036673016374	active site
1036673016375	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
1036673016376	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1036673016377	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1036673016378	DNA binding residues [nucleotide binding]
1036673016379	putative dimer interface [polypeptide binding]; other site
1036673016380	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1036673016381	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1036673016382	Cupin domain; Region: Cupin_2; pfam07883
1036673016383	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673016384	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673016385	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673016386	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1036673016387	Arylamine N-acetyltransferase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: NhoA; COG2162
1036673016388	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1036673016389	active site
1036673016390	oxyanion hole [active]
1036673016391	catalytic triad [active]
1036673016392	Domain of unknown function (DUF4179); Region: DUF4179; pfam13786
1036673016393	RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3
1036673016394	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673016395	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673016396	DNA binding residues [nucleotide binding]
1036673016397	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1036673016398	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673016399	S-adenosylmethionine binding site [chemical binding]; other site
1036673016400	Predicted membrane protein [Function unknown]; Region: COG2322
1036673016401	Spore germination protein; Region: Spore_permease; cl17796
1036673016402	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673016403	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1036673016404	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1036673016405	Walker A/P-loop; other site
1036673016406	ATP binding site [chemical binding]; other site
1036673016407	Q-loop/lid; other site
1036673016408	ABC transporter signature motif; other site
1036673016409	Walker B; other site
1036673016410	D-loop; other site
1036673016411	H-loop/switch region; other site
1036673016412	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1036673016413	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1036673016414	Walker A/P-loop; other site
1036673016415	ATP binding site [chemical binding]; other site
1036673016416	Q-loop/lid; other site
1036673016417	ABC transporter signature motif; other site
1036673016418	Walker B; other site
1036673016419	D-loop; other site
1036673016420	H-loop/switch region; other site
1036673016421	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1036673016422	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1036673016423	TM-ABC transporter signature motif; other site
1036673016424	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673016425	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1036673016426	TM-ABC transporter signature motif; other site
1036673016427	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1036673016428	Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342
1036673016429	dimerization interface [polypeptide binding]; other site
1036673016430	ligand binding site [chemical binding]; other site
1036673016431	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
1036673016432	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1036673016433	substrate binding site [chemical binding]; other site
1036673016434	ATP binding site [chemical binding]; other site
1036673016435	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1036673016436	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673016437	Cytochrome c; Region: Cytochrom_C; pfam00034
1036673016438	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1036673016439	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673016440	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673016441	dimer interface [polypeptide binding]; other site
1036673016442	conserved gate region; other site
1036673016443	putative PBP binding loops; other site
1036673016444	ABC-ATPase subunit interface; other site
1036673016445	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673016446	dimer interface [polypeptide binding]; other site
1036673016447	conserved gate region; other site
1036673016448	putative PBP binding loops; other site
1036673016449	ABC-ATPase subunit interface; other site
1036673016450	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673016451	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1036673016452	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673016453	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673016454	DNA binding site [nucleotide binding]
1036673016455	domain linker motif; other site
1036673016456	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673016457	dimerization interface [polypeptide binding]; other site
1036673016458	ligand binding site [chemical binding]; other site
1036673016459	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673016460	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673016461	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1036673016462	Bacillus subtilis (Bs) citrate synthase CS-I_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BsCS-I_like; cd06109
1036673016463	dimer interface [polypeptide binding]; other site
1036673016464	Citrate synthase; Region: Citrate_synt; pfam00285
1036673016465	active site
1036673016466	citrylCoA binding site [chemical binding]; other site
1036673016467	oxalacetate/citrate binding site [chemical binding]; other site
1036673016468	coenzyme A binding site [chemical binding]; other site
1036673016469	catalytic triad [active]
1036673016470	peptide synthase; Validated; Region: PRK05691
1036673016471	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
1036673016472	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1036673016473	active site
1036673016474	DNA binding site [nucleotide binding]
1036673016475	Int/Topo IB signature motif; other site
1036673016476	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1036673016477	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1036673016478	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1036673016479	putative substrate binding site [chemical binding]; other site
1036673016480	putative ATP binding site [chemical binding]; other site
1036673016481	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673016482	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673016483	active site
1036673016484	catalytic tetrad [active]
1036673016485	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1036673016486	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673016487	Coenzyme A binding pocket [chemical binding]; other site
1036673016488	amidase; Provisional; Region: PRK06828
1036673016489	Amidase; Region: Amidase; cl11426
1036673016490	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1036673016491	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673016492	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673016493	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
1036673016494	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
1036673016495	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1036673016496	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1036673016497	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1036673016498	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
1036673016499	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1036673016500	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1036673016501	active site
1036673016502	dimer interface [polypeptide binding]; other site
1036673016503	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673016504	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1036673016505	AAA domain; Region: AAA_18; pfam13238
1036673016506	active site
1036673016507	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1036673016508	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1036673016509	Predicted transcriptional regulators [Transcription]; Region: COG1695
1036673016510	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1036673016511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673016512	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673016513	putative substrate translocation pore; other site
1036673016514	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673016515	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673016516	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1036673016517	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1036673016518	Transposase domain (DUF772); Region: DUF772; pfam05598
1036673016519	Transposase, Mutator family; Region: Transposase_mut; pfam00872
1036673016520	MULE transposase domain; Region: MULE; pfam10551
1036673016521	Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310
1036673016522	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1036673016523	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673016524	NAD(P) binding site [chemical binding]; other site
1036673016525	active site
1036673016526	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673016527	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
1036673016528	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1036673016529	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673016530	dimerization interface [polypeptide binding]; other site
1036673016531	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673016532	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673016533	dimer interface [polypeptide binding]; other site
1036673016534	putative CheW interface [polypeptide binding]; other site
1036673016535	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673016536	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1036673016537	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673016538	Walker A/P-loop; other site
1036673016539	ATP binding site [chemical binding]; other site
1036673016540	Q-loop/lid; other site
1036673016541	ABC transporter signature motif; other site
1036673016542	Walker B; other site
1036673016543	D-loop; other site
1036673016544	H-loop/switch region; other site
1036673016545	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673016546	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673016547	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1036673016548	Walker A/P-loop; other site
1036673016549	ATP binding site [chemical binding]; other site
1036673016550	Q-loop/lid; other site
1036673016551	ABC transporter signature motif; other site
1036673016552	Walker B; other site
1036673016553	D-loop; other site
1036673016554	H-loop/switch region; other site
1036673016555	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1036673016556	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1036673016557	Walker A/P-loop; other site
1036673016558	ATP binding site [chemical binding]; other site
1036673016559	Q-loop/lid; other site
1036673016560	ABC transporter signature motif; other site
1036673016561	Walker B; other site
1036673016562	D-loop; other site
1036673016563	H-loop/switch region; other site
1036673016564	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1036673016565	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673016566	dimer interface [polypeptide binding]; other site
1036673016567	conserved gate region; other site
1036673016568	putative PBP binding loops; other site
1036673016569	ABC-ATPase subunit interface; other site
1036673016570	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1036673016571	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673016572	substrate binding pocket [chemical binding]; other site
1036673016573	membrane-bound complex binding site; other site
1036673016574	hinge residues; other site
1036673016575	drug efflux system protein MdtG; Provisional; Region: PRK09874
1036673016576	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673016577	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
1036673016578	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1036673016579	Uncharacterized conserved protein [Function unknown]; Region: COG4278
1036673016580	Transposase domain (DUF772); Region: DUF772; pfam05598
1036673016581	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1036673016582	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1036673016583	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1036673016584	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1036673016585	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
1036673016586	active site
1036673016587	catalytic site [active]
1036673016588	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673016589	dimerization interface [polypeptide binding]; other site
1036673016590	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673016591	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673016592	dimer interface [polypeptide binding]; other site
1036673016593	putative CheW interface [polypeptide binding]; other site
1036673016594	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1036673016595	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1036673016596	ligand binding site [chemical binding]; other site
1036673016597	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673016598	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673016599	active site
1036673016600	phosphorylation site [posttranslational modification]
1036673016601	intermolecular recognition site; other site
1036673016602	dimerization interface [polypeptide binding]; other site
1036673016603	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673016604	dimer interface [polypeptide binding]; other site
1036673016605	phosphorylation site [posttranslational modification]
1036673016606	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673016607	ATP binding site [chemical binding]; other site
1036673016608	Mg2+ binding site [ion binding]; other site
1036673016609	G-X-G motif; other site
1036673016610	CheB methylesterase; Region: CheB_methylest; pfam01339
1036673016611	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1036673016612	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1036673016613	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1036673016614	Nitrate and nitrite sensing; Region: NIT; pfam08376
1036673016615	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1036673016616	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673016617	dimerization interface [polypeptide binding]; other site
1036673016618	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1036673016619	GAF domain; Region: GAF; pfam01590
1036673016620	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673016621	dimer interface [polypeptide binding]; other site
1036673016622	phosphorylation site [posttranslational modification]
1036673016623	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673016624	ATP binding site [chemical binding]; other site
1036673016625	Mg2+ binding site [ion binding]; other site
1036673016626	G-X-G motif; other site
1036673016627	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673016628	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673016629	active site
1036673016630	phosphorylation site [posttranslational modification]
1036673016631	intermolecular recognition site; other site
1036673016632	dimerization interface [polypeptide binding]; other site
1036673016633	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1036673016634	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673016635	active site
1036673016636	phosphorylation site [posttranslational modification]
1036673016637	intermolecular recognition site; other site
1036673016638	dimerization interface [polypeptide binding]; other site
1036673016639	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1036673016640	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673016641	active site
1036673016642	phosphorylation site [posttranslational modification]
1036673016643	intermolecular recognition site; other site
1036673016644	dimerization interface [polypeptide binding]; other site
1036673016645	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1036673016646	active site
1036673016647	intersubunit interactions; other site
1036673016648	catalytic residue [active]
1036673016649	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1036673016650	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1036673016651	TPP-binding site [chemical binding]; other site
1036673016652	dimer interface [polypeptide binding]; other site
1036673016653	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1036673016654	PYR/PP interface [polypeptide binding]; other site
1036673016655	dimer interface [polypeptide binding]; other site
1036673016656	TPP binding site [chemical binding]; other site
1036673016657	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1036673016658	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673016659	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673016660	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673016661	dimerization interface [polypeptide binding]; other site
1036673016662	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673016663	dimerization interface [polypeptide binding]; other site
1036673016664	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673016665	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673016666	dimer interface [polypeptide binding]; other site
1036673016667	putative CheW interface [polypeptide binding]; other site
1036673016668	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1036673016669	CoenzymeA binding site [chemical binding]; other site
1036673016670	subunit interaction site [polypeptide binding]; other site
1036673016671	PHB binding site; other site
1036673016672	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
1036673016673	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1036673016674	acyl-activating enzyme (AAE) consensus motif; other site
1036673016675	putative AMP binding site [chemical binding]; other site
1036673016676	putative active site [active]
1036673016677	putative CoA binding site [chemical binding]; other site
1036673016678	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1036673016679	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1036673016680	active site
1036673016681	acetyl-CoA acetyltransferase; Provisional; Region: PRK07661
1036673016682	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1036673016683	dimer interface [polypeptide binding]; other site
1036673016684	active site
1036673016685	3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250
1036673016686	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1036673016687	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1036673016688	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1036673016689	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1036673016690	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1036673016691	substrate binding site [chemical binding]; other site
1036673016692	oxyanion hole (OAH) forming residues; other site
1036673016693	trimer interface [polypeptide binding]; other site
1036673016694	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1036673016695	4Fe-4S binding domain; Region: Fer4; cl02805
1036673016696	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1036673016697	Cysteine-rich domain; Region: CCG; pfam02754
1036673016698	Cysteine-rich domain; Region: CCG; pfam02754
1036673016699	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673016700	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673016701	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
1036673016702	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1036673016703	Ligand binding site [chemical binding]; other site
1036673016704	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1036673016705	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1036673016706	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1036673016707	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1036673016708	uracil transporter; Provisional; Region: PRK10720
1036673016709	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673016710	Protein of unknown function (DUF3231); Region: DUF3231; pfam11553
1036673016711	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673016712	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673016713	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673016714	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1036673016715	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1036673016716	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673016717	substrate binding pocket [chemical binding]; other site
1036673016718	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
1036673016719	membrane-bound complex binding site; other site
1036673016720	hinge residues; other site
1036673016721	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1036673016722	regulatory protein interface [polypeptide binding]; other site
1036673016723	active site
1036673016724	regulatory phosphorylation site [posttranslational modification]; other site
1036673016725	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3333
1036673016726	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1036673016727	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1036673016728	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1036673016729	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673016730	putative active site [active]
1036673016731	heme pocket [chemical binding]; other site
1036673016732	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673016733	ATP binding site [chemical binding]; other site
1036673016734	Mg2+ binding site [ion binding]; other site
1036673016735	G-X-G motif; other site
1036673016736	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1036673016737	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673016738	active site
1036673016739	phosphorylation site [posttranslational modification]
1036673016740	intermolecular recognition site; other site
1036673016741	dimerization interface [polypeptide binding]; other site
1036673016742	Transcriptional regulator; Region: CitT; pfam12431
1036673016743	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1036673016744	LysE type translocator; Region: LysE; pfam01810
1036673016745	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1036673016746	Spore germination protein; Region: Spore_permease; cl17796
1036673016747	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1036673016748	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1036673016749	active site
1036673016750	non-prolyl cis peptide bond; other site
1036673016751	Predicted transcriptional regulator [Transcription]; Region: COG4189
1036673016752	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673016753	dimerization interface [polypeptide binding]; other site
1036673016754	putative DNA binding site [nucleotide binding]; other site
1036673016755	putative Zn2+ binding site [ion binding]; other site
1036673016756	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
1036673016757	active site
1036673016758	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673016759	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673016760	dimer interface [polypeptide binding]; other site
1036673016761	conserved gate region; other site
1036673016762	putative PBP binding loops; other site
1036673016763	ABC-ATPase subunit interface; other site
1036673016764	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673016765	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673016766	dimer interface [polypeptide binding]; other site
1036673016767	ABC-ATPase subunit interface; other site
1036673016768	putative PBP binding loops; other site
1036673016769	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673016770	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673016771	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
1036673016772	active site
1036673016773	Predicted transcriptional regulator [Transcription]; Region: COG4189
1036673016774	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673016775	dimerization interface [polypeptide binding]; other site
1036673016776	putative DNA binding site [nucleotide binding]; other site
1036673016777	putative Zn2+ binding site [ion binding]; other site
1036673016778	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1036673016779	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1036673016780	Metal-binding active site; metal-binding site
1036673016781	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673016782	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673016783	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673016784	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673016785	alpha-galactosidase; Region: PLN02808; cl17638
1036673016786	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673016787	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673016788	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673016789	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1036673016790	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1036673016791	intersubunit interface [polypeptide binding]; other site
1036673016792	active site
1036673016793	zinc binding site [ion binding]; other site
1036673016794	Na+ binding site [ion binding]; other site
1036673016795	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1036673016796	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1036673016797	tetrameric interface [polypeptide binding]; other site
1036673016798	NAD binding site [chemical binding]; other site
1036673016799	catalytic residues [active]
1036673016800	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1036673016801	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1036673016802	substrate binding site [chemical binding]; other site
1036673016803	ATP binding site [chemical binding]; other site
1036673016804	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1036673016805	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1036673016806	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1036673016807	PYR/PP interface [polypeptide binding]; other site
1036673016808	dimer interface [polypeptide binding]; other site
1036673016809	TPP binding site [chemical binding]; other site
1036673016810	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1036673016811	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
1036673016812	TPP-binding site; other site
1036673016813	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673016814	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673016815	ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594
1036673016816	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1036673016817	siderophore binding site; other site
1036673016818	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1036673016819	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673016820	ABC-ATPase subunit  interface; other site
1036673016821	dimer interface [polypeptide binding]; other site
1036673016822	putative PBP binding regions; other site
1036673016823	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1036673016824	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673016825	ABC-ATPase subunit  interface; other site
1036673016826	dimer interface [polypeptide binding]; other site
1036673016827	putative PBP binding regions; other site
1036673016828	Predicted ATPase [General function prediction only]; Region: COG3910
1036673016829	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673016830	Walker A/P-loop; other site
1036673016831	ATP binding site [chemical binding]; other site
1036673016832	Q-loop/lid; other site
1036673016833	ABC transporter signature motif; other site
1036673016834	Walker B; other site
1036673016835	D-loop; other site
1036673016836	H-loop/switch region; other site
1036673016837	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673016838	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1036673016839	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1036673016840	inhibitor binding site; inhibition site
1036673016841	active site
1036673016842	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673016843	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673016844	dimer interface [polypeptide binding]; other site
1036673016845	conserved gate region; other site
1036673016846	putative PBP binding loops; other site
1036673016847	ABC-ATPase subunit interface; other site
1036673016848	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673016849	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673016850	dimer interface [polypeptide binding]; other site
1036673016851	conserved gate region; other site
1036673016852	ABC-ATPase subunit interface; other site
1036673016853	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673016854	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673016855	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673016856	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1036673016857	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
1036673016858	active site
1036673016859	Pectate lyase; Region: Pec_lyase_C; cl01593
1036673016860	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673016861	Interdomain contacts; other site
1036673016862	Cytokine receptor motif; other site
1036673016863	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673016864	Interdomain contacts; other site
1036673016865	Cytokine receptor motif; other site
1036673016866	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673016867	Interdomain contacts; other site
1036673016868	Cytokine receptor motif; other site
1036673016869	putative pectinesterase; Region: PLN02432; cl01911
1036673016870	Pectinesterase; Region: Pectinesterase; pfam01095
1036673016871	conserved hypothetical protein; Region: lin0512_fam; TIGR02058
1036673016872	Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893
1036673016873	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1036673016874	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1036673016875	putative metal binding site; other site
1036673016876	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
1036673016877	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1036673016878	binding surface
1036673016879	TPR motif; other site
1036673016880	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1036673016881	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1036673016882	active site
1036673016883	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
1036673016884	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673016885	putative homodimer interface [polypeptide binding]; other site
1036673016886	Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327
1036673016887	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
1036673016888	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
1036673016889	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673016890	putative homodimer interface [polypeptide binding]; other site
1036673016891	Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318
1036673016892	metal binding site [ion binding]; metal-binding site
1036673016893	active site
1036673016894	Putative esterase; Region: Esterase; pfam00756
1036673016895	S-formylglutathione hydrolase; Region: PLN02442
1036673016896	Putative esterase; Region: Esterase; pfam00756
1036673016897	S-layer homology domain; Region: SLH; pfam00395
1036673016898	S-layer homology domain; Region: SLH; pfam00395
1036673016899	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1036673016900	active site
1036673016901	Protein of unknown function (DUF1361); Region: DUF1361; cl01784
1036673016902	Alanine-glyoxylate amino-transferase; Region: Aminotran_MocR; pfam12897
1036673016903	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673016904	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673016905	homodimer interface [polypeptide binding]; other site
1036673016906	catalytic residue [active]
1036673016907	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664
1036673016908	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1036673016909	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673016910	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673016911	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673016912	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673016913	Broad specificity phosphatase PhoE and related phosphatases [General function prediction only]; Region: phoE; COG0406
1036673016914	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673016915	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673016916	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673016917	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1036673016918	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1036673016919	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1036673016920	Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295
1036673016921	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673016922	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673016923	DNA binding site [nucleotide binding]
1036673016924	domain linker motif; other site
1036673016925	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1036673016926	dimerization interface [polypeptide binding]; other site
1036673016927	ligand binding site [chemical binding]; other site
1036673016928	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
1036673016929	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673016930	Interdomain contacts; other site
1036673016931	Cytokine receptor motif; other site
1036673016932	Cellulose binding domain; Region: CBM_3; pfam00942
1036673016933	Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297
1036673016934	Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341
1036673016935	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673016936	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673016937	Interdomain contacts; other site
1036673016938	Cytokine receptor motif; other site
1036673016939	Cellulose binding domain; Region: CBM_3; pfam00942
1036673016940	Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588
1036673016941	dimer interface [polypeptide binding]; other site
1036673016942	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673016943	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1036673016944	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673016945	Coenzyme A binding pocket [chemical binding]; other site
1036673016946	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036673016947	HEAT repeats; Region: HEAT_2; pfam13646
1036673016948	Uncharacterized protein domain similar to Clostridium thermocellum 2751; Region: Cthe_2751_like; cd11743
1036673016949	dimer interface [polypeptide binding]; other site
1036673016950	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1036673016951	Glycosyl hydrolase family 43; Region: GH43_2; cd08981
1036673016952	active site
1036673016953	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673016954	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1036673016955	Coenzyme A binding pocket [chemical binding]; other site
1036673016956	Putative transcription activator [Transcription]; Region: TenA; COG0819
1036673016957	acetylornithine deacetylase; Validated; Region: PRK08596
1036673016958	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1036673016959	metal binding site [ion binding]; metal-binding site
1036673016960	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673016961	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1036673016962	Walker A/P-loop; other site
1036673016963	ATP binding site [chemical binding]; other site
1036673016964	Q-loop/lid; other site
1036673016965	ABC transporter signature motif; other site
1036673016966	Walker B; other site
1036673016967	D-loop; other site
1036673016968	H-loop/switch region; other site
1036673016969	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1036673016970	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1036673016971	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1036673016972	Walker A/P-loop; other site
1036673016973	ATP binding site [chemical binding]; other site
1036673016974	Q-loop/lid; other site
1036673016975	ABC transporter signature motif; other site
1036673016976	Walker B; other site
1036673016977	D-loop; other site
1036673016978	H-loop/switch region; other site
1036673016979	BioY family; Region: BioY; pfam02632
1036673016980	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
1036673016981	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
1036673016982	putative active site [active]
1036673016983	putative NTP binding site [chemical binding]; other site
1036673016984	putative nucleic acid binding site [nucleotide binding]; other site
1036673016985	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
1036673016986	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1036673016987	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1036673016988	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673016989	DNA-binding site [nucleotide binding]; DNA binding site
1036673016990	FCD domain; Region: FCD; pfam07729
1036673016991	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1036673016992	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
1036673016993	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
1036673016994	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1036673016995	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
1036673016996	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
1036673016997	Cysteine-rich domain; Region: CCG; pfam02754
1036673016998	Cysteine-rich domain; Region: CCG; pfam02754
1036673016999	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1036673017000	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1036673017001	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1036673017002	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
1036673017003	N- and C-terminal domain interface [polypeptide binding]; other site
1036673017004	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
1036673017005	active site
1036673017006	putative catalytic site [active]
1036673017007	metal binding site [ion binding]; metal-binding site
1036673017008	ATP binding site [chemical binding]; other site
1036673017009	carbohydrate binding site [chemical binding]; other site
1036673017010	L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629
1036673017011	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
1036673017012	Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100
1036673017013	short chain dehydrogenase; Validated; Region: PRK08324
1036673017014	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
1036673017015	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
1036673017016	putative NAD(P) binding site [chemical binding]; other site
1036673017017	active site
1036673017018	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
1036673017019	intersubunit interface [polypeptide binding]; other site
1036673017020	active site
1036673017021	Zn2+ binding site [ion binding]; other site
1036673017022	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1036673017023	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
1036673017024	active site
1036673017025	intersubunit interface [polypeptide binding]; other site
1036673017026	Zn2+ binding site [ion binding]; other site
1036673017027	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1036673017028	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673017029	MarR family; Region: MarR_2; pfam12802
1036673017030	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673017031	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673017032	putative substrate translocation pore; other site
1036673017033	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673017034	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1036673017035	NAD(P) binding site [chemical binding]; other site
1036673017036	active site
1036673017037	Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011
1036673017038	Cellulose binding domain; Region: CBM_3; pfam00942
1036673017039	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673017040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673017041	active site
1036673017042	phosphorylation site [posttranslational modification]
1036673017043	intermolecular recognition site; other site
1036673017044	dimerization interface [polypeptide binding]; other site
1036673017045	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673017046	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673017047	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1036673017048	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1036673017049	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1036673017050	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673017051	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673017052	homodimer interface [polypeptide binding]; other site
1036673017053	catalytic residue [active]
1036673017054	Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821
1036673017055	active site
1036673017056	catalytic triad [active]
1036673017057	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673017058	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673017059	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673017060	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673017061	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673017062	Predicted membrane protein [Function unknown]; Region: COG4709
1036673017063	Regulatory protein YrvL; Region: YrvL; pfam14184
1036673017064	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
1036673017065	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
1036673017066	Domain of unknown function (DUF4284); Region: DUF4284; pfam14112
1036673017067	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
1036673017068	dimerization interface [polypeptide binding]; other site
1036673017069	NAD binding site [chemical binding]; other site
1036673017070	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1036673017071	ligand binding site [chemical binding]; other site
1036673017072	catalytic site [active]
1036673017073	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673017074	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673017075	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1036673017076	Walker A/P-loop; other site
1036673017077	ATP binding site [chemical binding]; other site
1036673017078	Q-loop/lid; other site
1036673017079	ABC transporter signature motif; other site
1036673017080	Walker B; other site
1036673017081	D-loop; other site
1036673017082	H-loop/switch region; other site
1036673017083	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673017084	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673017085	metal binding site [ion binding]; metal-binding site
1036673017086	active site
1036673017087	I-site; other site
1036673017088	Glycosyl hydrolase family 43, includes arabinoxylan arabinofuranohydrolase, beta-xylosidase, endo-1,4-beta-xylanase, alpha-L-arabinofuranosidase; Region: GH43_AXH_like; cd08990
1036673017089	substrate binding site [chemical binding]; other site
1036673017090	active site
1036673017091	Alpha-L-arabinofuranosidase B (ABFB); Region: AbfB; pfam05270
1036673017092	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
1036673017093	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1036673017094	S-layer homology domain; Region: SLH; pfam00395
1036673017095	S-layer homology domain; Region: SLH; pfam00395
1036673017096	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1036673017097	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1036673017098	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1036673017099	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
1036673017100	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1036673017101	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1036673017102	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
1036673017103	active site
1036673017104	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1036673017105	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673017106	substrate binding pocket [chemical binding]; other site
1036673017107	membrane-bound complex binding site; other site
1036673017108	hinge residues; other site
1036673017109	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1036673017110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673017111	dimer interface [polypeptide binding]; other site
1036673017112	conserved gate region; other site
1036673017113	putative PBP binding loops; other site
1036673017114	ABC-ATPase subunit interface; other site
1036673017115	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1036673017116	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1036673017117	Walker A/P-loop; other site
1036673017118	ATP binding site [chemical binding]; other site
1036673017119	Q-loop/lid; other site
1036673017120	ABC transporter signature motif; other site
1036673017121	Walker B; other site
1036673017122	D-loop; other site
1036673017123	H-loop/switch region; other site
1036673017124	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1036673017125	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1036673017126	substrate binding pocket [chemical binding]; other site
1036673017127	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1036673017128	Peptidase C26; Region: Peptidase_C26; pfam07722
1036673017129	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1036673017130	catalytic triad [active]
1036673017131	S-layer homology domain; Region: SLH; pfam00395
1036673017132	NTR_like domain; a beta barrel with an oligosaccharide/oligonucleotide-binding fold found in netrins, complement proteins, tissue inhibitors of metalloproteases (TIMP), and procollagen C-proteinase enhancers (PCOLCE), amongst others. In netrins, the...; Region: NTR_like; cl02512
1036673017133	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1036673017134	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1036673017135	nucleotide binding site [chemical binding]; other site
1036673017136	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673017137	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1036673017138	NlpC/P60 family; Region: NLPC_P60; pfam00877
1036673017139	Transglycosylase; Region: Transgly; pfam00912
1036673017140	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1036673017141	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1036673017142	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1036673017143	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1036673017144	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1036673017145	putative pectinesterase; Region: PLN02432; cl01911
1036673017146	YhfH-like protein; Region: YhfH; pfam14149
1036673017147	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1036673017148	Protein export membrane protein; Region: SecD_SecF; cl14618
1036673017149	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673017150	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673017151	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673017152	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673017153	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1036673017154	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1036673017155	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1036673017156	metal-binding site [ion binding]
1036673017157	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1036673017158	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1036673017159	metal-binding site [ion binding]
1036673017160	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1036673017161	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673017162	motif II; other site
1036673017163	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1036673017164	metal-binding site [ion binding]
1036673017165	Arginase family; Region: Arginase; cd09989
1036673017166	active site
1036673017167	Mn binding site [ion binding]; other site
1036673017168	oligomer interface [polypeptide binding]; other site
1036673017169	Arginase family; Region: Arginase; cd09989
1036673017170	active site
1036673017171	Mn binding site [ion binding]; other site
1036673017172	oligomer interface [polypeptide binding]; other site
1036673017173	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673017174	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673017175	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673017176	dimerization interface [polypeptide binding]; other site
1036673017177	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
1036673017178	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1036673017179	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1036673017180	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1036673017181	S-methylmethionine transporter; Provisional; Region: PRK11387
1036673017182	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1036673017183	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1036673017184	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1036673017185	NAD(P) binding site [chemical binding]; other site
1036673017186	ornithine--oxo-acid transaminase; Provisional; Region: rocD; PRK04073
1036673017187	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036673017188	inhibitor-cofactor binding pocket; inhibition site
1036673017189	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673017190	catalytic residue [active]
1036673017191	PAS domain; Region: PAS; smart00091
1036673017192	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673017193	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1036673017194	Walker A motif; other site
1036673017195	ATP binding site [chemical binding]; other site
1036673017196	Walker B motif; other site
1036673017197	arginine finger; other site
1036673017198	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1036673017199	active site
1036673017200	hypothetical protein; Provisional; Region: PRK09739
1036673017201	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1036673017202	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673017203	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673017204	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673017205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673017206	active site
1036673017207	phosphorylation site [posttranslational modification]
1036673017208	intermolecular recognition site; other site
1036673017209	dimerization interface [polypeptide binding]; other site
1036673017210	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673017211	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673017212	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673017213	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673017214	dimerization interface [polypeptide binding]; other site
1036673017215	Histidine kinase; Region: His_kinase; pfam06580
1036673017216	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673017217	ATP binding site [chemical binding]; other site
1036673017218	G-X-G motif; other site
1036673017219	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673017220	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673017221	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673017222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673017223	dimer interface [polypeptide binding]; other site
1036673017224	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673017225	ABC-ATPase subunit interface; other site
1036673017226	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
1036673017227	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673017228	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673017229	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673017230	dimer interface [polypeptide binding]; other site
1036673017231	conserved gate region; other site
1036673017232	putative PBP binding loops; other site
1036673017233	ABC-ATPase subunit interface; other site
1036673017234	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673017235	dimer interface [polypeptide binding]; other site
1036673017236	conserved gate region; other site
1036673017237	putative PBP binding loops; other site
1036673017238	ABC-ATPase subunit interface; other site
1036673017239	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673017240	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673017241	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673017242	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673017243	dimerization interface [polypeptide binding]; other site
1036673017244	Histidine kinase; Region: His_kinase; pfam06580
1036673017245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673017246	ATP binding site [chemical binding]; other site
1036673017247	Mg2+ binding site [ion binding]; other site
1036673017248	G-X-G motif; other site
1036673017249	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1036673017250	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673017251	active site
1036673017252	phosphorylation site [posttranslational modification]
1036673017253	intermolecular recognition site; other site
1036673017254	dimerization interface [polypeptide binding]; other site
1036673017255	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673017256	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1036673017257	putative FMN binding site [chemical binding]; other site
1036673017258	NADPH bind site [chemical binding]; other site
1036673017259	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
1036673017260	putative FMN binding site [chemical binding]; other site
1036673017261	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
1036673017262	YcaO-like family; Region: YcaO; pfam02624
1036673017263	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
1036673017264	putative thiazole-containing bacteriocin maturation protein; Region: ocin_ThiF_like; TIGR03693
1036673017265	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
1036673017266	DinB superfamily; Region: DinB_2; pfam12867
1036673017267	Protein of unknown function (DUF664); Region: DUF664; pfam04978
1036673017268	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1036673017269	classical (c) SDRs; Region: SDR_c; cd05233
1036673017270	NAD(P) binding site [chemical binding]; other site
1036673017271	active site
1036673017272	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1036673017273	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
1036673017274	active site 1 [active]
1036673017275	dimer interface [polypeptide binding]; other site
1036673017276	hexamer interface [polypeptide binding]; other site
1036673017277	active site 2 [active]
1036673017278	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673017279	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673017280	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673017281	dimerization interface [polypeptide binding]; other site
1036673017282	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673017283	dimerization interface [polypeptide binding]; other site
1036673017284	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673017285	Histidine kinase; Region: His_kinase; pfam06580
1036673017286	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673017287	ATP binding site [chemical binding]; other site
1036673017288	Mg2+ binding site [ion binding]; other site
1036673017289	G-X-G motif; other site
1036673017290	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673017291	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673017292	active site
1036673017293	phosphorylation site [posttranslational modification]
1036673017294	intermolecular recognition site; other site
1036673017295	dimerization interface [polypeptide binding]; other site
1036673017296	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673017297	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673017298	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673017299	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673017300	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673017301	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673017302	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673017303	dimer interface [polypeptide binding]; other site
1036673017304	conserved gate region; other site
1036673017305	putative PBP binding loops; other site
1036673017306	ABC-ATPase subunit interface; other site
1036673017307	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673017308	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
1036673017309	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1036673017310	sugar binding site [chemical binding]; other site
1036673017311	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1036673017312	sugar binding site [chemical binding]; other site
1036673017313	Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310
1036673017314	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1036673017315	sugar binding site [chemical binding]; other site
1036673017316	Cupin; Region: Cupin_1; smart00835
1036673017317	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673017318	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673017319	DNA binding site [nucleotide binding]
1036673017320	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1036673017321	Domain of unknown function (DUF336); Region: DUF336; cl01249
1036673017322	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
1036673017323	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673017324	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673017325	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1036673017326	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673017327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673017328	dimer interface [polypeptide binding]; other site
1036673017329	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673017330	ABC-ATPase subunit interface; other site
1036673017331	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673017332	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673017333	dimer interface [polypeptide binding]; other site
1036673017334	conserved gate region; other site
1036673017335	ABC-ATPase subunit interface; other site
1036673017336	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673017337	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673017338	metal binding site [ion binding]; metal-binding site
1036673017339	active site
1036673017340	I-site; other site
1036673017341	short chain dehydrogenase; Validated; Region: PRK06182
1036673017342	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1036673017343	NADP binding site [chemical binding]; other site
1036673017344	active site
1036673017345	steroid binding site; other site
1036673017346	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673017347	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673017348	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
1036673017349	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1036673017350	putative ligand binding site [chemical binding]; other site
1036673017351	Cache domain; Region: Cache_1; pfam02743
1036673017352	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673017353	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673017354	dimerization interface [polypeptide binding]; other site
1036673017355	Histidine kinase; Region: His_kinase; pfam06580
1036673017356	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673017357	ATP binding site [chemical binding]; other site
1036673017358	Mg2+ binding site [ion binding]; other site
1036673017359	G-X-G motif; other site
1036673017360	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673017361	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673017362	active site
1036673017363	phosphorylation site [posttranslational modification]
1036673017364	intermolecular recognition site; other site
1036673017365	dimerization interface [polypeptide binding]; other site
1036673017366	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673017367	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673017368	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673017369	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
1036673017370	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1036673017371	putative ligand binding site [chemical binding]; other site
1036673017372	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673017373	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1036673017374	TM-ABC transporter signature motif; other site
1036673017375	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1036673017376	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1036673017377	Walker A/P-loop; other site
1036673017378	ATP binding site [chemical binding]; other site
1036673017379	Q-loop/lid; other site
1036673017380	ABC transporter signature motif; other site
1036673017381	Walker B; other site
1036673017382	D-loop; other site
1036673017383	H-loop/switch region; other site
1036673017384	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1036673017385	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1036673017386	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673017387	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673017388	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673017389	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1036673017390	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
1036673017391	metal binding site [ion binding]; metal-binding site
1036673017392	substrate binding pocket [chemical binding]; other site
1036673017393	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1036673017394	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1036673017395	inhibitor site; inhibition site
1036673017396	active site
1036673017397	dimer interface [polypeptide binding]; other site
1036673017398	catalytic residue [active]
1036673017399	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1036673017400	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1036673017401	NAD(P) binding site [chemical binding]; other site
1036673017402	catalytic residues [active]
1036673017403	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673017404	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673017405	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673017406	dimer interface [polypeptide binding]; other site
1036673017407	conserved gate region; other site
1036673017408	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1036673017409	ABC-ATPase subunit interface; other site
1036673017410	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673017411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673017412	dimer interface [polypeptide binding]; other site
1036673017413	conserved gate region; other site
1036673017414	ABC-ATPase subunit interface; other site
1036673017415	nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769
1036673017416	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673017417	Walker A/P-loop; other site
1036673017418	ATP binding site [chemical binding]; other site
1036673017419	Q-loop/lid; other site
1036673017420	ABC transporter signature motif; other site
1036673017421	Walker B; other site
1036673017422	D-loop; other site
1036673017423	H-loop/switch region; other site
1036673017424	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1036673017425	nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770
1036673017426	Walker A/P-loop; other site
1036673017427	ATP binding site [chemical binding]; other site
1036673017428	Q-loop/lid; other site
1036673017429	ABC transporter signature motif; other site
1036673017430	Walker B; other site
1036673017431	D-loop; other site
1036673017432	H-loop/switch region; other site
1036673017433	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1036673017434	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1036673017435	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1036673017436	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673017437	dimer interface [polypeptide binding]; other site
1036673017438	conserved gate region; other site
1036673017439	putative PBP binding loops; other site
1036673017440	ABC-ATPase subunit interface; other site
1036673017441	nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789
1036673017442	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673017443	dimer interface [polypeptide binding]; other site
1036673017444	conserved gate region; other site
1036673017445	putative PBP binding loops; other site
1036673017446	ABC-ATPase subunit interface; other site
1036673017447	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1036673017448	The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489
1036673017449	substrate binding site [chemical binding]; other site
1036673017450	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673017451	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673017452	putative substrate translocation pore; other site
1036673017453	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
1036673017454	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
1036673017455	putative N- and C-terminal domain interface [polypeptide binding]; other site
1036673017456	putative active site [active]
1036673017457	MgATP binding site [chemical binding]; other site
1036673017458	catalytic site [active]
1036673017459	metal binding site [ion binding]; metal-binding site
1036673017460	putative carbohydrate binding site [chemical binding]; other site
1036673017461	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673017462	Helix-turn-helix domain; Region: HTH_18; pfam12833
1036673017463	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673017464	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1036673017465	putative catalytic site [active]
1036673017466	putative metal binding site [ion binding]; other site
1036673017467	putative phosphate binding site [ion binding]; other site
1036673017468	Jacalin-like lectin domain; Region: Jacalin_like; cl03205
1036673017469	putative sugar binding site [chemical binding]; other site
1036673017470	PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397
1036673017471	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1036673017472	active site
1036673017473	Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951
1036673017474	S-layer homology domain; Region: SLH; pfam00395
1036673017475	S-layer homology domain; Region: SLH; pfam00395
1036673017476	S-layer homology domain; Region: SLH; pfam00395
1036673017477	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1036673017478	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1036673017479	FtsX-like permease family; Region: FtsX; pfam02687
1036673017480	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1036673017481	FtsX-like permease family; Region: FtsX; pfam02687
1036673017482	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036673017483	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1036673017484	Walker A/P-loop; other site
1036673017485	ATP binding site [chemical binding]; other site
1036673017486	Q-loop/lid; other site
1036673017487	ABC transporter signature motif; other site
1036673017488	Walker B; other site
1036673017489	D-loop; other site
1036673017490	H-loop/switch region; other site
1036673017491	sporulation sigma factor SigK; Reviewed; Region: PRK05803
1036673017492	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673017493	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673017494	DNA binding residues [nucleotide binding]
1036673017495	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673017496	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673017497	dimer interface [polypeptide binding]; other site
1036673017498	conserved gate region; other site
1036673017499	ABC-ATPase subunit interface; other site
1036673017500	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673017501	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673017502	dimer interface [polypeptide binding]; other site
1036673017503	conserved gate region; other site
1036673017504	putative PBP binding loops; other site
1036673017505	ABC-ATPase subunit interface; other site
1036673017506	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1036673017507	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673017508	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1036673017509	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673017510	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673017511	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1036673017512	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1036673017513	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1036673017514	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1036673017515	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673017516	putative DNA binding site [nucleotide binding]; other site
1036673017517	putative Zn2+ binding site [ion binding]; other site
1036673017518	AsnC family; Region: AsnC_trans_reg; pfam01037
1036673017519	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1036673017520	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1036673017521	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1036673017522	putative active site [active]
1036673017523	putative metal binding site [ion binding]; other site
1036673017524	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1036673017525	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1036673017526	generic binding surface I; other site
1036673017527	generic binding surface II; other site
1036673017528	ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822
1036673017529	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673017530	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673017531	DNA binding residues [nucleotide binding]
1036673017532	dimerization interface [polypeptide binding]; other site
1036673017533	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1036673017534	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06710
1036673017535	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
1036673017536	acyl-activating enzyme (AAE) consensus motif; other site
1036673017537	putative AMP binding site [chemical binding]; other site
1036673017538	putative active site [active]
1036673017539	putative CoA binding site [chemical binding]; other site
1036673017540	Protein of unknown function (DUF429); Region: DUF429; cl12046
1036673017541	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
1036673017542	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1036673017543	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1036673017544	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1036673017545	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1036673017546	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1036673017547	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036673017548	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673017549	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673017550	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1036673017551	Melibiase; Region: Melibiase; pfam02065
1036673017552	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673017553	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673017554	metal binding site [ion binding]; metal-binding site
1036673017555	active site
1036673017556	I-site; other site
1036673017557	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1036673017558	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036673017559	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036673017560	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1036673017561	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
1036673017562	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1036673017563	E3 interaction surface; other site
1036673017564	lipoyl attachment site [posttranslational modification]; other site
1036673017565	e3 binding domain; Region: E3_binding; pfam02817
1036673017566	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1036673017567	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1036673017568	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1036673017569	alpha subunit interface [polypeptide binding]; other site
1036673017570	TPP binding site [chemical binding]; other site
1036673017571	heterodimer interface [polypeptide binding]; other site
1036673017572	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1036673017573	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
1036673017574	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1036673017575	TPP-binding site [chemical binding]; other site
1036673017576	heterodimer interface [polypeptide binding]; other site
1036673017577	tetramer interface [polypeptide binding]; other site
1036673017578	phosphorylation loop region [posttranslational modification]
1036673017579	Putative esterase; Region: Esterase; pfam00756
1036673017580	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1036673017581	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1036673017582	GDYXXLXY protein; Region: GDYXXLXY; pfam14345
1036673017583	Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925
1036673017584	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673017585	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1036673017586	active site
1036673017587	metal binding site [ion binding]; metal-binding site
1036673017588	TM1410 hypothetical-related protein; Region: DUF297; pfam03537
1036673017589	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673017590	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673017591	active site
1036673017592	phosphorylation site [posttranslational modification]
1036673017593	intermolecular recognition site; other site
1036673017594	dimerization interface [polypeptide binding]; other site
1036673017595	GAF domain; Region: GAF_3; pfam13492
1036673017596	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4878
1036673017597	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924
1036673017598	NodB motif; other site
1036673017599	putative active site [active]
1036673017600	putative catalytic site [active]
1036673017601	putative Zn binding site [ion binding]; other site
1036673017602	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
1036673017603	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673017604	Predicted membrane protein [Function unknown]; Region: COG4267
1036673017605	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673017606	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673017607	dimer interface [polypeptide binding]; other site
1036673017608	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673017609	ATP binding site [chemical binding]; other site
1036673017610	Mg2+ binding site [ion binding]; other site
1036673017611	G-X-G motif; other site
1036673017612	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1036673017613	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1036673017614	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1036673017615	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673017616	dimerization interface [polypeptide binding]; other site
1036673017617	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673017618	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673017619	dimer interface [polypeptide binding]; other site
1036673017620	putative CheW interface [polypeptide binding]; other site
1036673017621	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1036673017622	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
1036673017623	Peptidase family U32; Region: Peptidase_U32; pfam01136
1036673017624	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1036673017625	Peptidase family U32; Region: Peptidase_U32; pfam01136
1036673017626	YceG-like family; Region: YceG; pfam02618
1036673017627	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1036673017628	dimerization interface [polypeptide binding]; other site
1036673017629	hypothetical protein; Provisional; Region: PRK13678
1036673017630	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1036673017631	hypothetical protein; Provisional; Region: PRK05473
1036673017632	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1036673017633	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1036673017634	motif 1; other site
1036673017635	active site
1036673017636	motif 2; other site
1036673017637	motif 3; other site
1036673017638	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1036673017639	DHHA1 domain; Region: DHHA1; pfam02272
1036673017640	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338
1036673017641	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673017642	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673017643	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673017644	Spore germination protein; Region: Spore_permease; cl17796
1036673017645	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1036673017646	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1036673017647	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
1036673017648	PRC-barrel domain; Region: PRC; pfam05239
1036673017649	PRC-barrel domain; Region: PRC; pfam05239
1036673017650	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1036673017651	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1036673017652	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036673017653	catalytic residue [active]
1036673017654	Predicted transcriptional regulator [Transcription]; Region: COG1959
1036673017655	Transcriptional regulator; Region: Rrf2; pfam02082
1036673017656	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
1036673017657	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1036673017658	Ligand Binding Site [chemical binding]; other site
1036673017659	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1036673017660	Domain of unknown function DUF21; Region: DUF21; pfam01595
1036673017661	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1036673017662	Transporter associated domain; Region: CorC_HlyC; smart01091
1036673017663	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
1036673017664	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
1036673017665	recombination factor protein RarA; Reviewed; Region: PRK13342
1036673017666	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673017667	Walker A motif; other site
1036673017668	ATP binding site [chemical binding]; other site
1036673017669	Walker B motif; other site
1036673017670	arginine finger; other site
1036673017671	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1036673017672	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
1036673017673	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
1036673017674	putative ATP binding site [chemical binding]; other site
1036673017675	putative substrate interface [chemical binding]; other site
1036673017676	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1036673017677	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1036673017678	dimer interface [polypeptide binding]; other site
1036673017679	anticodon binding site; other site
1036673017680	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1036673017681	homodimer interface [polypeptide binding]; other site
1036673017682	motif 1; other site
1036673017683	active site
1036673017684	motif 2; other site
1036673017685	GAD domain; Region: GAD; pfam02938
1036673017686	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1036673017687	active site
1036673017688	motif 3; other site
1036673017689	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1036673017690	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1036673017691	dimer interface [polypeptide binding]; other site
1036673017692	motif 1; other site
1036673017693	active site
1036673017694	motif 2; other site
1036673017695	motif 3; other site
1036673017696	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1036673017697	anticodon binding site; other site
1036673017698	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1036673017699	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1036673017700	putative active site [active]
1036673017701	dimerization interface [polypeptide binding]; other site
1036673017702	putative tRNAtyr binding site [nucleotide binding]; other site
1036673017703	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1036673017704	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036673017705	Zn2+ binding site [ion binding]; other site
1036673017706	Mg2+ binding site [ion binding]; other site
1036673017707	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1036673017708	synthetase active site [active]
1036673017709	NTP binding site [chemical binding]; other site
1036673017710	metal binding site [ion binding]; metal-binding site
1036673017711	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1036673017712	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1036673017713	CotH protein; Region: CotH; pfam08757
1036673017714	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036673017715	active site
1036673017716	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1036673017717	DHH family; Region: DHH; pfam01368
1036673017718	DHHA1 domain; Region: DHHA1; pfam02272
1036673017719	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
1036673017720	Cation efflux family; Region: Cation_efflux; cl00316
1036673017721	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1036673017722	Protein export membrane protein; Region: SecD_SecF; pfam02355
1036673017723	protein-export membrane protein SecD; Region: secD; TIGR01129
1036673017724	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1036673017725	Post-transcriptional regulator; Region: Post_transc_reg; pfam13797
1036673017726	stage V sporulation protein B; Region: spore_V_B; TIGR02900
1036673017727	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1036673017728	Predicted membrane protein [Function unknown]; Region: COG2323
1036673017729	Preprotein translocase subunit; Region: YajC; pfam02699
1036673017730	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1036673017731	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1036673017732	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1036673017733	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1036673017734	Stage II sporulation protein; Region: SpoIID; pfam08486
1036673017735	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
1036673017736	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1036673017737	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673017738	Walker A motif; other site
1036673017739	ATP binding site [chemical binding]; other site
1036673017740	Walker B motif; other site
1036673017741	arginine finger; other site
1036673017742	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1036673017743	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1036673017744	RuvA N terminal domain; Region: RuvA_N; pfam01330
1036673017745	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
1036673017746	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1036673017747	active site
1036673017748	putative DNA-binding cleft [nucleotide binding]; other site
1036673017749	dimer interface [polypeptide binding]; other site
1036673017750	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1036673017751	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1036673017752	active site
1036673017753	BofC C-terminal domain; Region: BofC_C; pfam08955
1036673017754	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1036673017755	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1036673017756	Catalytic site [active]
1036673017757	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673017758	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1036673017759	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673017760	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
1036673017761	MgtC family; Region: MgtC; pfam02308
1036673017762	prephenate dehydratase; Provisional; Region: PRK11898
1036673017763	Prephenate dehydratase; Region: PDT; pfam00800
1036673017764	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1036673017765	putative L-Phe binding site [chemical binding]; other site
1036673017766	homoserine kinase; Provisional; Region: PRK01212
1036673017767	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1036673017768	homoserine dehydrogenase; Provisional; Region: PRK06349
1036673017769	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1036673017770	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1036673017771	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1036673017772	hypothetical protein; Provisional; Region: PRK04435
1036673017773	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1036673017774	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1036673017775	nudix motif; other site
1036673017776	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673017777	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1036673017778	Walker A/P-loop; other site
1036673017779	ATP binding site [chemical binding]; other site
1036673017780	Q-loop/lid; other site
1036673017781	ABC transporter signature motif; other site
1036673017782	Walker B; other site
1036673017783	D-loop; other site
1036673017784	H-loop/switch region; other site
1036673017785	Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547
1036673017786	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1036673017787	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1036673017788	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
1036673017789	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
1036673017790	[4Fe-4S] binding site [ion binding]; other site
1036673017791	molybdopterin cofactor binding site; other site
1036673017792	This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex  and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508
1036673017793	molybdopterin cofactor binding site; other site
1036673017794	nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886
1036673017795	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673017796	putative substrate translocation pore; other site
1036673017797	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1036673017798	GTP1/OBG; Region: GTP1_OBG; pfam01018
1036673017799	Obg GTPase; Region: Obg; cd01898
1036673017800	G1 box; other site
1036673017801	GTP/Mg2+ binding site [chemical binding]; other site
1036673017802	Switch I region; other site
1036673017803	G2 box; other site
1036673017804	G3 box; other site
1036673017805	Switch II region; other site
1036673017806	G4 box; other site
1036673017807	G5 box; other site
1036673017808	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1036673017809	sensory histidine kinase DcuS; Provisional; Region: PRK11086
1036673017810	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1036673017811	Protein of unknown function (DUF464); Region: DUF464; pfam04327
1036673017812	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1036673017813	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1036673017814	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
1036673017815	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1036673017816	homodimer interface [polypeptide binding]; other site
1036673017817	oligonucleotide binding site [chemical binding]; other site
1036673017818	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
1036673017819	Peptidase family M50; Region: Peptidase_M50; pfam02163
1036673017820	active site
1036673017821	putative substrate binding region [chemical binding]; other site
1036673017822	Peptidase family M23; Region: Peptidase_M23; pfam01551
1036673017823	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1036673017824	Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894
1036673017825	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
1036673017826	Switch I; other site
1036673017827	Switch II; other site
1036673017828	septum formation inhibitor; Reviewed; Region: minC; PRK00513
1036673017829	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
1036673017830	rod shape-determining protein MreD; Region: MreD; cl01087
1036673017831	rod shape-determining protein MreC; Provisional; Region: PRK13922
1036673017832	rod shape-determining protein MreC; Region: MreC; pfam04085
1036673017833	rod shape-determining protein MreB; Provisional; Region: PRK13927
1036673017834	MreB and similar proteins; Region: MreB_like; cd10225
1036673017835	nucleotide binding site [chemical binding]; other site
1036673017836	Mg binding site [ion binding]; other site
1036673017837	putative protofilament interaction site [polypeptide binding]; other site
1036673017838	RodZ interaction site [polypeptide binding]; other site
1036673017839	hypothetical protein; Reviewed; Region: PRK00024
1036673017840	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1036673017841	MPN+ (JAMM) motif; other site
1036673017842	Zinc-binding site [ion binding]; other site
1036673017843	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1036673017844	active site
1036673017845	dimer interface [polypeptide binding]; other site
1036673017846	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1036673017847	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1036673017848	active site
1036673017849	metal binding site [ion binding]; metal-binding site
1036673017850	S-layer homology domain; Region: SLH; pfam00395
1036673017851	S-layer homology domain; Region: SLH; pfam00395
1036673017852	S-layer homology domain; Region: SLH; pfam00395
1036673017853	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1036673017854	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1036673017855	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1036673017856	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1036673017857	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1036673017858	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1036673017859	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1036673017860	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1036673017861	active site
1036673017862	HIGH motif; other site
1036673017863	nucleotide binding site [chemical binding]; other site
1036673017864	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1036673017865	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1036673017866	active site
1036673017867	KMSKS motif; other site
1036673017868	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1036673017869	tRNA binding surface [nucleotide binding]; other site
1036673017870	anticodon binding site; other site
1036673017871	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1036673017872	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673017873	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1036673017874	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1036673017875	active site
1036673017876	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1036673017877	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
1036673017878	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036673017879	inhibitor-cofactor binding pocket; inhibition site
1036673017880	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673017881	catalytic residue [active]
1036673017882	ferrochelatase; Provisional; Region: PRK12435
1036673017883	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1036673017884	C-terminal domain interface [polypeptide binding]; other site
1036673017885	active site
1036673017886	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1036673017887	active site
1036673017888	N-terminal domain interface [polypeptide binding]; other site
1036673017889	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
1036673017890	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1036673017891	substrate binding site [chemical binding]; other site
1036673017892	active site
1036673017893	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
1036673017894	dimer interface [polypeptide binding]; other site
1036673017895	active site
1036673017896	Schiff base residues; other site
1036673017897	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1036673017898	active site
1036673017899	SAM binding site [chemical binding]; other site
1036673017900	homodimer interface [polypeptide binding]; other site
1036673017901	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
1036673017902	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1036673017903	active site
1036673017904	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
1036673017905	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1036673017906	active site
1036673017907	domain interfaces; other site
1036673017908	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
1036673017909	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
1036673017910	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1036673017911	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
1036673017912	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
1036673017913	tRNA; other site
1036673017914	putative tRNA binding site [nucleotide binding]; other site
1036673017915	putative NADP binding site [chemical binding]; other site
1036673017916	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
1036673017917	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
1036673017918	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1036673017919	G1 box; other site
1036673017920	GTP/Mg2+ binding site [chemical binding]; other site
1036673017921	Switch I region; other site
1036673017922	G2 box; other site
1036673017923	G3 box; other site
1036673017924	Switch II region; other site
1036673017925	G4 box; other site
1036673017926	G5 box; other site
1036673017927	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1036673017928	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1036673017929	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1036673017930	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673017931	Walker A motif; other site
1036673017932	ATP binding site [chemical binding]; other site
1036673017933	Walker B motif; other site
1036673017934	arginine finger; other site
1036673017935	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1036673017936	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
1036673017937	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673017938	Walker A motif; other site
1036673017939	ATP binding site [chemical binding]; other site
1036673017940	Walker B motif; other site
1036673017941	arginine finger; other site
1036673017942	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1036673017943	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1036673017944	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1036673017945	active site
1036673017946	metal binding site [ion binding]; metal-binding site
1036673017947	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1036673017948	NodB motif; other site
1036673017949	putative active site [active]
1036673017950	putative catalytic site [active]
1036673017951	Zn binding site [ion binding]; other site
1036673017952	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1036673017953	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1036673017954	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1036673017955	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1036673017956	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1036673017957	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673017958	Walker A motif; other site
1036673017959	ATP binding site [chemical binding]; other site
1036673017960	Walker B motif; other site
1036673017961	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1036673017962	Clp protease; Region: CLP_protease; pfam00574
1036673017963	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1036673017964	oligomer interface [polypeptide binding]; other site
1036673017965	active site residues [active]
1036673017966	trigger factor; Provisional; Region: tig; PRK01490
1036673017967	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1036673017968	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1036673017969	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673017970	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673017971	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673017972	Spore germination protein; Region: Spore_permease; cl17796
1036673017973	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
1036673017974	active site
1036673017975	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
1036673017976	dimer interface [polypeptide binding]; other site
1036673017977	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
1036673017978	Ligand Binding Site [chemical binding]; other site
1036673017979	Molecular Tunnel; other site
1036673017980	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1036673017981	active site
1036673017982	dimerization interface [polypeptide binding]; other site
1036673017983	ribonuclease PH; Reviewed; Region: rph; PRK00173
1036673017984	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1036673017985	hexamer interface [polypeptide binding]; other site
1036673017986	active site
1036673017987	Sporulation and spore germination; Region: Germane; pfam10646
1036673017988	Spore germination protein [General function prediction only]; Region: COG5401
1036673017989	Sporulation and spore germination; Region: Germane; pfam10646
1036673017990	PAS domain S-box; Region: sensory_box; TIGR00229
1036673017991	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673017992	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673017993	metal binding site [ion binding]; metal-binding site
1036673017994	active site
1036673017995	I-site; other site
1036673017996	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1036673017997	tetramer interfaces [polypeptide binding]; other site
1036673017998	binuclear metal-binding site [ion binding]; other site
1036673017999	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673018000	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036673018001	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036673018002	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673018003	S-adenosylmethionine binding site [chemical binding]; other site
1036673018004	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1036673018005	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1036673018006	nucleotide binding site [chemical binding]; other site
1036673018007	DNA-sulfur modification-associated; Region: DndB; cl17621
1036673018008	DNA-sulfur modification-associated; Region: DndB; cl17621
1036673018009	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673018010	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673018011	active site
1036673018012	phosphorylation site [posttranslational modification]
1036673018013	intermolecular recognition site; other site
1036673018014	dimerization interface [polypeptide binding]; other site
1036673018015	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673018016	DNA binding residues [nucleotide binding]
1036673018017	dimerization interface [polypeptide binding]; other site
1036673018018	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1036673018019	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673018020	ATP binding site [chemical binding]; other site
1036673018021	Mg2+ binding site [ion binding]; other site
1036673018022	G-X-G motif; other site
1036673018023	Domain of unknown function (DUF4287); Region: DUF4287; pfam14117
1036673018024	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1036673018025	putative hydrophobic ligand binding site [chemical binding]; other site
1036673018026	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
1036673018027	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673018028	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
1036673018029	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
1036673018030	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1036673018031	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
1036673018032	tetramer interface [polypeptide binding]; other site
1036673018033	heme binding pocket [chemical binding]; other site
1036673018034	Cold-inducible protein YdjO; Region: YdjO; pfam14169
1036673018035	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673018036	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673018037	DNA binding residues [nucleotide binding]
1036673018038	dimerization interface [polypeptide binding]; other site
1036673018039	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
1036673018040	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
1036673018041	transmembrane helices; other site
1036673018042	Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831
1036673018043	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1036673018044	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
1036673018045	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673018046	S-adenosylmethionine binding site [chemical binding]; other site
1036673018047	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1036673018048	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1036673018049	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1036673018050	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1036673018051	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1036673018052	Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545
1036673018053	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673018054	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673018055	active site
1036673018056	phosphorylation site [posttranslational modification]
1036673018057	intermolecular recognition site; other site
1036673018058	dimerization interface [polypeptide binding]; other site
1036673018059	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673018060	DNA binding residues [nucleotide binding]
1036673018061	dimerization interface [polypeptide binding]; other site
1036673018062	Histidine kinase; Region: HisKA_3; pfam07730
1036673018063	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673018064	ATP binding site [chemical binding]; other site
1036673018065	Mg2+ binding site [ion binding]; other site
1036673018066	G-X-G motif; other site
1036673018067	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
1036673018068	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1036673018069	dimer interface [polypeptide binding]; other site
1036673018070	active site
1036673018071	CoA binding pocket [chemical binding]; other site
1036673018072	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
1036673018073	flagellar assembly protein H; Validated; Region: fliH; PRK05687
1036673018074	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1036673018075	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1036673018076	Probable Catalytic site; other site
1036673018077	metal-binding site
1036673018078	flagellar assembly protein H; Provisional; Region: fliH; PRK13386
1036673018079	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
1036673018080	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1036673018081	DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996
1036673018082	Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524
1036673018083	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1036673018084	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1036673018085	Probable Catalytic site; other site
1036673018086	metal-binding site
1036673018087	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1036673018088	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1036673018089	active site
1036673018090	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1036673018091	active site
1036673018092	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673018093	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1036673018094	Putative papain-like cysteine peptidase (DUF1796); Region: DUF1796; pfam08795
1036673018095	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673018096	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1036673018097	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1036673018098	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1036673018099	homotetramer interface [polypeptide binding]; other site
1036673018100	NADP-binding site; other site
1036673018101	substrate binding site [chemical binding]; other site
1036673018102	homodimer interface [polypeptide binding]; other site
1036673018103	active site
1036673018104	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1036673018105	dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091
1036673018106	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1036673018107	NADP binding site [chemical binding]; other site
1036673018108	active site
1036673018109	putative substrate binding site [chemical binding]; other site
1036673018110	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1036673018111	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1036673018112	NAD binding site [chemical binding]; other site
1036673018113	substrate binding site [chemical binding]; other site
1036673018114	homodimer interface [polypeptide binding]; other site
1036673018115	active site
1036673018116	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1036673018117	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1036673018118	active site
1036673018119	Histone H1-like nucleoprotein HC2; Region: HC2; pfam07382
1036673018120	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1036673018121	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673018122	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1036673018123	EcsC protein family; Region: EcsC; pfam12787
1036673018124	Cupin domain; Region: Cupin_2; pfam07883
1036673018125	O-Antigen ligase; Region: Wzy_C; pfam04932
1036673018126	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1036673018127	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673018128	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673018129	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673018130	MarR family; Region: MarR; pfam01047
1036673018131	MarR family; Region: MarR_2; cl17246
1036673018132	Pirin; Region: Pirin; pfam02678
1036673018133	Pirin-related protein [General function prediction only]; Region: COG1741
1036673018134	ba3-like heme-copper oxidase subunit I.  The ba3 family of heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and some archaea which catalyze the reduction of O2 and simultaneously pump protons across the...; Region: ba3-like_Oxidase_I; cd01660
1036673018135	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1036673018136	Low-spin heme binding site [chemical binding]; other site
1036673018137	Subunit I/II interface [polypeptide binding]; other site
1036673018138	Putative Q-pathway; other site
1036673018139	Putative D-pathway homolog; other site
1036673018140	Putative alternate electron transfer pathway; other site
1036673018141	Putative water exit pathway; other site
1036673018142	Binuclear center (active site) [active]
1036673018143	Putative K-pathway homolog; other site
1036673018144	Putative proton exit pathway; other site
1036673018145	Subunit I/IIa interface [polypeptide binding]; other site
1036673018146	Electron transfer pathway; other site
1036673018147	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1036673018148	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1036673018149	Ion channel; Region: Ion_trans_2; pfam07885
1036673018150	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1036673018151	TrkA-N domain; Region: TrkA_N; pfam02254
1036673018152	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
1036673018153	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
1036673018154	Na binding site [ion binding]; other site
1036673018155	Protein of unknown function, DUF485; Region: DUF485; pfam04341
1036673018156	Putative transcription activator [Transcription]; Region: TenA; COG0819
1036673018157	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1036673018158	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1036673018159	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1036673018160	Walker A/P-loop; other site
1036673018161	ATP binding site [chemical binding]; other site
1036673018162	Q-loop/lid; other site
1036673018163	ABC transporter signature motif; other site
1036673018164	Walker B; other site
1036673018165	D-loop; other site
1036673018166	H-loop/switch region; other site
1036673018167	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1036673018168	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1036673018169	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1036673018170	G1 box; other site
1036673018171	Walker A/P-loop; other site
1036673018172	GTP/Mg2+ binding site [chemical binding]; other site
1036673018173	ATP binding site [chemical binding]; other site
1036673018174	Q-loop/lid; other site
1036673018175	ABC transporter signature motif; other site
1036673018176	Walker B; other site
1036673018177	D-loop; other site
1036673018178	H-loop/switch region; other site
1036673018179	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943
1036673018180	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
1036673018181	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673018182	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673018183	putative substrate translocation pore; other site
1036673018184	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1036673018185	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036673018186	Zn2+ binding site [ion binding]; other site
1036673018187	Mg2+ binding site [ion binding]; other site
1036673018188	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1036673018189	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673018190	DNA-binding site [nucleotide binding]; DNA binding site
1036673018191	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673018192	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673018193	homodimer interface [polypeptide binding]; other site
1036673018194	catalytic residue [active]
1036673018195	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673018196	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
1036673018197	Cupin domain; Region: Cupin_2; pfam07883
1036673018198	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673018199	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673018200	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673018201	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1036673018202	glutaminase A; Region: Gln_ase; TIGR03814
1036673018203	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673018204	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1036673018205	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1036673018206	TM-ABC transporter signature motif; other site
1036673018207	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
1036673018208	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1036673018209	Walker A/P-loop; other site
1036673018210	ATP binding site [chemical binding]; other site
1036673018211	Q-loop/lid; other site
1036673018212	ABC transporter signature motif; other site
1036673018213	Walker B; other site
1036673018214	D-loop; other site
1036673018215	H-loop/switch region; other site
1036673018216	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1036673018217	ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213
1036673018218	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1036673018219	putative ligand binding site [chemical binding]; other site
1036673018220	Domain of unknown function (DUF1963); Region: DUF1963; pfam09234
1036673018221	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673018222	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673018223	active site
1036673018224	phosphorylation site [posttranslational modification]
1036673018225	intermolecular recognition site; other site
1036673018226	dimerization interface [polypeptide binding]; other site
1036673018227	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673018228	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673018229	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673018230	Cache domain; Region: Cache_1; pfam02743
1036673018231	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673018232	dimerization interface [polypeptide binding]; other site
1036673018233	Histidine kinase; Region: His_kinase; pfam06580
1036673018234	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673018235	ATP binding site [chemical binding]; other site
1036673018236	Mg2+ binding site [ion binding]; other site
1036673018237	G-X-G motif; other site
1036673018238	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1036673018239	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1036673018240	ligand binding site [chemical binding]; other site
1036673018241	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
1036673018242	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1036673018243	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673018244	putative DNA binding site [nucleotide binding]; other site
1036673018245	putative Zn2+ binding site [ion binding]; other site
1036673018246	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1036673018247	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673018248	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1036673018249	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673018250	homodimer interface [polypeptide binding]; other site
1036673018251	catalytic residue [active]
1036673018252	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1036673018253	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673018254	NAD(P) binding site [chemical binding]; other site
1036673018255	active site
1036673018256	Helix-turn-helix domain; Region: HTH_31; pfam13560
1036673018257	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673018258	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673018259	Domain of unknown function (DUF4253); Region: DUF4253; pfam14062
1036673018260	threonine dehydratase; Validated; Region: PRK08639
1036673018261	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1036673018262	tetramer interface [polypeptide binding]; other site
1036673018263	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673018264	catalytic residue [active]
1036673018265	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1036673018266	putative Ile/Val binding site [chemical binding]; other site
1036673018267	S-layer homology domain; Region: SLH; pfam00395
1036673018268	S-layer homology domain; Region: SLH; pfam00395
1036673018269	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1036673018270	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036673018271	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673018272	MarR family; Region: MarR; pfam01047
1036673018273	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673018274	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673018275	putative substrate translocation pore; other site
1036673018276	helicase 45; Provisional; Region: PTZ00424
1036673018277	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1036673018278	ATP binding site [chemical binding]; other site
1036673018279	Mg++ binding site [ion binding]; other site
1036673018280	motif III; other site
1036673018281	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673018282	nucleotide binding region [chemical binding]; other site
1036673018283	ATP-binding site [chemical binding]; other site
1036673018284	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1036673018285	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
1036673018286	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1036673018287	active site
1036673018288	HIGH motif; other site
1036673018289	nucleotide binding site [chemical binding]; other site
1036673018290	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1036673018291	active site
1036673018292	KMSKS motif; other site
1036673018293	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
1036673018294	tRNA binding surface [nucleotide binding]; other site
1036673018295	anticodon binding site; other site
1036673018296	Ferredoxin [Energy production and conversion]; Region: COG1146
1036673018297	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1036673018298	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1036673018299	Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053
1036673018300	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1036673018301	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
1036673018302	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673018303	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673018304	dimerization interface [polypeptide binding]; other site
1036673018305	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1036673018306	MOSC domain; Region: MOSC; pfam03473
1036673018307	3-alpha domain; Region: 3-alpha; pfam03475
1036673018308	RNA polymerase recycling family C-terminal; Region: RapA_C; pfam12137
1036673018309	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1036673018310	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1036673018311	Protein of unknown function (DUF2573); Region: DUF2573; pfam10835
1036673018312	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1036673018313	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673018314	NAD(P) binding site [chemical binding]; other site
1036673018315	active site
1036673018316	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
1036673018317	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
1036673018318	VanW like protein; Region: VanW; pfam04294
1036673018319	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683
1036673018320	nudix motif; other site
1036673018321	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1036673018322	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1036673018323	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1036673018324	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1036673018325	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
1036673018326	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673018327	Walker A/P-loop; other site
1036673018328	ATP binding site [chemical binding]; other site
1036673018329	Q-loop/lid; other site
1036673018330	ABC transporter signature motif; other site
1036673018331	Walker B; other site
1036673018332	D-loop; other site
1036673018333	H-loop/switch region; other site
1036673018334	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1036673018335	Serpin (serine protease inhibitor); Region: Serpin; pfam00079
1036673018336	serpin-like protein; Provisional; Region: PHA02660
1036673018337	reactive center loop; other site
1036673018338	Serpin (serine protease inhibitor); Region: Serpin; pfam00079
1036673018339	serpin-like protein; Provisional; Region: PHA02660
1036673018340	reactive center loop; other site
1036673018341	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
1036673018342	Cysteine dioxygenase type I; Region: CDO_I; pfam05995
1036673018343	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673018344	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673018345	active site
1036673018346	phosphorylation site [posttranslational modification]
1036673018347	intermolecular recognition site; other site
1036673018348	dimerization interface [polypeptide binding]; other site
1036673018349	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673018350	DNA binding site [nucleotide binding]
1036673018351	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673018352	dimerization interface [polypeptide binding]; other site
1036673018353	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673018354	dimer interface [polypeptide binding]; other site
1036673018355	phosphorylation site [posttranslational modification]
1036673018356	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673018357	ATP binding site [chemical binding]; other site
1036673018358	Mg2+ binding site [ion binding]; other site
1036673018359	G-X-G motif; other site
1036673018360	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
1036673018361	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673018362	active site
1036673018363	motif I; other site
1036673018364	motif II; other site
1036673018365	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673018366	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1036673018367	active site
1036673018368	DinB superfamily; Region: DinB_2; pfam12867
1036673018369	metal-dependent hydrolase; Provisional; Region: PRK13291
1036673018370	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1036673018371	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1036673018372	DNA binding residues [nucleotide binding]
1036673018373	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1036673018374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673018375	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673018376	putative substrate translocation pore; other site
1036673018377	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673018378	Predicted transcriptional regulators [Transcription]; Region: COG1695
1036673018379	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1036673018380	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673018381	putative substrate translocation pore; other site
1036673018382	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673018383	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673018384	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673018385	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673018386	dimerization interface [polypeptide binding]; other site
1036673018387	histidinol-phosphatase; Provisional; Region: PRK07328
1036673018388	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
1036673018389	active site
1036673018390	dimer interface [polypeptide binding]; other site
1036673018391	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1036673018392	active site
1036673018393	catalytic triad [active]
1036673018394	oxyanion hole [active]
1036673018395	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1036673018396	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1036673018397	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1036673018398	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673018399	active site
1036673018400	phosphorylation site [posttranslational modification]
1036673018401	intermolecular recognition site; other site
1036673018402	dimerization interface [polypeptide binding]; other site
1036673018403	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673018404	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673018405	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673018406	dimerization interface [polypeptide binding]; other site
1036673018407	Histidine kinase; Region: His_kinase; pfam06580
1036673018408	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673018409	Mg2+ binding site [ion binding]; other site
1036673018410	G-X-G motif; other site
1036673018411	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673018412	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673018413	dimer interface [polypeptide binding]; other site
1036673018414	conserved gate region; other site
1036673018415	putative PBP binding loops; other site
1036673018416	ABC-ATPase subunit interface; other site
1036673018417	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673018418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673018419	dimer interface [polypeptide binding]; other site
1036673018420	conserved gate region; other site
1036673018421	putative PBP binding loops; other site
1036673018422	ABC-ATPase subunit interface; other site
1036673018423	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673018424	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673018425	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
1036673018426	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1036673018427	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
1036673018428	active site turn [active]
1036673018429	phosphorylation site [posttranslational modification]
1036673018430	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1036673018431	HPr interaction site; other site
1036673018432	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1036673018433	active site
1036673018434	phosphorylation site [posttranslational modification]
1036673018435	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1036673018436	CAT RNA binding domain; Region: CAT_RBD; smart01061
1036673018437	PRD domain; Region: PRD; pfam00874
1036673018438	PRD domain; Region: PRD; pfam00874
1036673018439	Predicted transcriptional regulators [Transcription]; Region: COG1695
1036673018440	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1036673018441	hypothetical protein; Validated; Region: PRK07668
1036673018442	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
1036673018443	active site
1036673018444	catalytic site [active]
1036673018445	substrate binding site [chemical binding]; other site
1036673018446	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673018447	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673018448	S-layer homology domain; Region: SLH; pfam00395
1036673018449	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673018450	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673018451	Beta-lactamase; Region: Beta-lactamase; pfam00144
1036673018452	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1036673018453	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1036673018454	Histidine kinase; Region: HisKA_3; pfam07730
1036673018455	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673018456	ATP binding site [chemical binding]; other site
1036673018457	Mg2+ binding site [ion binding]; other site
1036673018458	G-X-G motif; other site
1036673018459	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673018460	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673018461	active site
1036673018462	phosphorylation site [posttranslational modification]
1036673018463	intermolecular recognition site; other site
1036673018464	dimerization interface [polypeptide binding]; other site
1036673018465	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673018466	DNA binding residues [nucleotide binding]
1036673018467	dimerization interface [polypeptide binding]; other site
1036673018468	Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide,  which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068
1036673018469	heme-binding site [chemical binding]; other site
1036673018470	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673018471	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673018472	dimer interface [polypeptide binding]; other site
1036673018473	putative CheW interface [polypeptide binding]; other site
1036673018474	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673018475	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673018476	active site
1036673018477	phosphorylation site [posttranslational modification]
1036673018478	intermolecular recognition site; other site
1036673018479	dimerization interface [polypeptide binding]; other site
1036673018480	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673018481	DNA binding site [nucleotide binding]
1036673018482	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1036673018483	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673018484	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673018485	dimer interface [polypeptide binding]; other site
1036673018486	phosphorylation site [posttranslational modification]
1036673018487	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673018488	ATP binding site [chemical binding]; other site
1036673018489	Mg2+ binding site [ion binding]; other site
1036673018490	G-X-G motif; other site
1036673018491	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1036673018492	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
1036673018493	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1036673018494	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673018495	S-adenosylmethionine binding site [chemical binding]; other site
1036673018496	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1036673018497	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673018498	putative active site [active]
1036673018499	heme pocket [chemical binding]; other site
1036673018500	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673018501	dimer interface [polypeptide binding]; other site
1036673018502	phosphorylation site [posttranslational modification]
1036673018503	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673018504	ATP binding site [chemical binding]; other site
1036673018505	Mg2+ binding site [ion binding]; other site
1036673018506	G-X-G motif; other site
1036673018507	UDP-glucose 4-epimerase; Region: PLN02240
1036673018508	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1036673018509	NAD binding site [chemical binding]; other site
1036673018510	homodimer interface [polypeptide binding]; other site
1036673018511	active site
1036673018512	substrate binding site [chemical binding]; other site
1036673018513	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
1036673018514	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1036673018515	Protein of unknown function (DUF466); Region: DUF466; pfam04328
1036673018516	carbon starvation protein A; Provisional; Region: PRK15015
1036673018517	Carbon starvation protein CstA; Region: CstA; pfam02554
1036673018518	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
1036673018519	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1036673018520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673018521	active site
1036673018522	phosphorylation site [posttranslational modification]
1036673018523	intermolecular recognition site; other site
1036673018524	dimerization interface [polypeptide binding]; other site
1036673018525	LytTr DNA-binding domain; Region: LytTR; smart00850
1036673018526	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
1036673018527	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1036673018528	Histidine kinase; Region: His_kinase; pfam06580
1036673018529	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673018530	ATP binding site [chemical binding]; other site
1036673018531	Mg2+ binding site [ion binding]; other site
1036673018532	G-X-G motif; other site
1036673018533	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
1036673018534	active site
1036673018535	metal binding site [ion binding]; metal-binding site
1036673018536	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1036673018537	Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298
1036673018538	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1036673018539	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1036673018540	putative active site [active]
1036673018541	putative metal binding site [ion binding]; other site
1036673018542	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1036673018543	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673018544	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673018545	putative substrate translocation pore; other site
1036673018546	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673018547	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673018548	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673018549	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673018550	dimer interface [polypeptide binding]; other site
1036673018551	conserved gate region; other site
1036673018552	putative PBP binding loops; other site
1036673018553	ABC-ATPase subunit interface; other site
1036673018554	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1036673018555	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673018556	dimer interface [polypeptide binding]; other site
1036673018557	conserved gate region; other site
1036673018558	putative PBP binding loops; other site
1036673018559	ABC-ATPase subunit interface; other site
1036673018560	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673018561	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673018562	dimerization interface [polypeptide binding]; other site
1036673018563	Histidine kinase; Region: His_kinase; pfam06580
1036673018564	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673018565	ATP binding site [chemical binding]; other site
1036673018566	Mg2+ binding site [ion binding]; other site
1036673018567	G-X-G motif; other site
1036673018568	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673018569	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673018570	active site
1036673018571	phosphorylation site [posttranslational modification]
1036673018572	intermolecular recognition site; other site
1036673018573	dimerization interface [polypeptide binding]; other site
1036673018574	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673018575	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673018576	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673018577	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1036673018578	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673018579	Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947
1036673018580	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1036673018581	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1036673018582	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1036673018583	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673018584	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673018585	active site
1036673018586	phosphorylation site [posttranslational modification]
1036673018587	intermolecular recognition site; other site
1036673018588	dimerization interface [polypeptide binding]; other site
1036673018589	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673018590	DNA binding site [nucleotide binding]
1036673018591	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
1036673018592	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036673018593	catalytic residue [active]
1036673018594	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
1036673018595	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1036673018596	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
1036673018597	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1036673018598	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673018599	non-specific DNA binding site [nucleotide binding]; other site
1036673018600	salt bridge; other site
1036673018601	sequence-specific DNA binding site [nucleotide binding]; other site
1036673018602	Anti-repressor SinI; Region: SinI; pfam08671
1036673018603	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1036673018604	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673018605	non-specific DNA binding site [nucleotide binding]; other site
1036673018606	salt bridge; other site
1036673018607	sequence-specific DNA binding site [nucleotide binding]; other site
1036673018608	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1036673018609	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673018610	non-specific DNA binding site [nucleotide binding]; other site
1036673018611	salt bridge; other site
1036673018612	sequence-specific DNA binding site [nucleotide binding]; other site
1036673018613	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1036673018614	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1036673018615	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
1036673018616	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1036673018617	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1036673018618	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
1036673018619	Right handed beta helix region; Region: Beta_helix; pfam13229
1036673018620	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1036673018621	Right handed beta helix region; Region: Beta_helix; pfam13229
1036673018622	Kelch motif; Region: Kelch_1; pfam01344
1036673018623	Galactose oxidase, central domain; Region: Kelch_3; cl02701
1036673018624	Kelch domain; Region: Kelch; smart00612
1036673018625	Galactose oxidase, central domain; Region: Kelch_4; pfam13418
1036673018626	Kelch domain; Region: Kelch; smart00612
1036673018627	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
1036673018628	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
1036673018629	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
1036673018630	trimer interface [polypeptide binding]; other site
1036673018631	active site
1036673018632	substrate binding site [chemical binding]; other site
1036673018633	CoA binding site [chemical binding]; other site
1036673018634	Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039
1036673018635	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1036673018636	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1036673018637	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1036673018638	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1036673018639	active site
1036673018640	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1036673018641	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1036673018642	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1036673018643	active site
1036673018644	Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662
1036673018645	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1036673018646	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1036673018647	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1036673018648	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1036673018649	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673018650	This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823
1036673018651	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673018652	WzyE protein; Region: WzyE; cl11643
1036673018653	O-Antigen ligase; Region: Wzy_C; pfam04932
1036673018654	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp1; TIGR03087
1036673018655	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1036673018656	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1036673018657	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1036673018658	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1036673018659	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1036673018660	active site
1036673018661	tetramer interface; other site
1036673018662	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1036673018663	Chain length determinant protein; Region: Wzz; cl15801
1036673018664	putative glycosyl transferase; Provisional; Region: PRK10307
1036673018665	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
1036673018666	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673018667	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1036673018668	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1036673018669	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673018670	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673018671	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1036673018672	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1036673018673	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1036673018674	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1036673018675	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1036673018676	NADP-binding site; other site
1036673018677	homotetramer interface [polypeptide binding]; other site
1036673018678	substrate binding site [chemical binding]; other site
1036673018679	homodimer interface [polypeptide binding]; other site
1036673018680	active site
1036673018681	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1036673018682	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1036673018683	NADP binding site [chemical binding]; other site
1036673018684	active site
1036673018685	putative substrate binding site [chemical binding]; other site
1036673018686	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1036673018687	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1036673018688	active site
1036673018689	tetramer interface; other site
1036673018690	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1036673018691	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1036673018692	Chain length determinant protein; Region: Wzz; cl15801
1036673018693	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1036673018694	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1036673018695	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673018696	sequence-specific DNA binding site [nucleotide binding]; other site
1036673018697	salt bridge; other site
1036673018698	glutamine synthetase, type I; Region: GlnA; TIGR00653
1036673018699	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1036673018700	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1036673018701	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
1036673018702	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1036673018703	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; cl01261
1036673018704	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1036673018705	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1036673018706	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673018707	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673018708	dimerization interface [polypeptide binding]; other site
1036673018709	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673018710	dimer interface [polypeptide binding]; other site
1036673018711	phosphorylation site [posttranslational modification]
1036673018712	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673018713	ATP binding site [chemical binding]; other site
1036673018714	Mg2+ binding site [ion binding]; other site
1036673018715	G-X-G motif; other site
1036673018716	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673018717	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673018718	active site
1036673018719	phosphorylation site [posttranslational modification]
1036673018720	intermolecular recognition site; other site
1036673018721	dimerization interface [polypeptide binding]; other site
1036673018722	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673018723	DNA binding site [nucleotide binding]
1036673018724	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1036673018725	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1036673018726	protein binding site [polypeptide binding]; other site
1036673018727	YugN-like family; Region: YugN; pfam08868
1036673018728	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1036673018729	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
1036673018730	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1036673018731	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1036673018732	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1036673018733	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1036673018734	active site
1036673018735	dimer interface [polypeptide binding]; other site
1036673018736	motif 1; other site
1036673018737	motif 2; other site
1036673018738	motif 3; other site
1036673018739	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1036673018740	anticodon binding site; other site
1036673018741	YtxC-like family; Region: YtxC; pfam08812
1036673018742	Predicted membrane protein [Function unknown]; Region: COG3371
1036673018743	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673018744	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673018745	metal binding site [ion binding]; metal-binding site
1036673018746	active site
1036673018747	I-site; other site
1036673018748	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1036673018749	binding surface
1036673018750	TPR motif; other site
1036673018751	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1036673018752	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1036673018753	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673018754	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1036673018755	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
1036673018756	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673018757	FeS/SAM binding site; other site
1036673018758	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
1036673018759	cystathionine gamma-synthase; Reviewed; Region: PRK08247
1036673018760	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1036673018761	homodimer interface [polypeptide binding]; other site
1036673018762	substrate-cofactor binding pocket; other site
1036673018763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673018764	catalytic residue [active]
1036673018765	Homoserine O-succinyltransferase; Region: HTS; pfam04204
1036673018766	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1036673018767	proposed active site lysine [active]
1036673018768	conserved cys residue [active]
1036673018769	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1036673018770	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
1036673018771	oligomer interface [polypeptide binding]; other site
1036673018772	metal binding site [ion binding]; metal-binding site
1036673018773	metal binding site [ion binding]; metal-binding site
1036673018774	putative Cl binding site [ion binding]; other site
1036673018775	aspartate ring; other site
1036673018776	basic sphincter; other site
1036673018777	hydrophobic gate; other site
1036673018778	periplasmic entrance; other site
1036673018779	HRDC domain; Region: HRDC; pfam00570
1036673018780	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1036673018781	Protein of unknown function (DUF3055); Region: DUF3055; pfam11256
1036673018782	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
1036673018783	Predicted transcriptional regulator [Transcription]; Region: COG4189
1036673018784	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673018785	putative DNA binding site [nucleotide binding]; other site
1036673018786	dimerization interface [polypeptide binding]; other site
1036673018787	putative Zn2+ binding site [ion binding]; other site
1036673018788	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
1036673018789	5'-3' exonuclease; Region: 53EXOc; smart00475
1036673018790	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1036673018791	active site
1036673018792	metal binding site 1 [ion binding]; metal-binding site
1036673018793	putative 5' ssDNA interaction site; other site
1036673018794	metal binding site 3; metal-binding site
1036673018795	metal binding site 2 [ion binding]; metal-binding site
1036673018796	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1036673018797	putative DNA binding site [nucleotide binding]; other site
1036673018798	putative metal binding site [ion binding]; other site
1036673018799	Cupin domain; Region: Cupin_2; pfam07883
1036673018800	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673018801	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673018802	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673018803	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673018804	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673018805	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673018806	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673018807	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673018808	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673018809	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
1036673018810	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673018811	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673018812	homodimer interface [polypeptide binding]; other site
1036673018813	catalytic residue [active]
1036673018814	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
1036673018815	Peptidase family M50; Region: Peptidase_M50; pfam02163
1036673018816	active site
1036673018817	putative substrate binding region [chemical binding]; other site
1036673018818	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
1036673018819	ArsC family; Region: ArsC; pfam03960
1036673018820	putative ArsC-like catalytic residues; other site
1036673018821	putative TRX-like catalytic residues [active]
1036673018822	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1036673018823	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1036673018824	putative active site [active]
1036673018825	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1036673018826	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036673018827	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1036673018828	active site
1036673018829	cob(I)alamin adenosyltransferase [Coenzyme transport and    metabolism]; Region: COG2096
1036673018830	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
1036673018831	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673018832	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673018833	homodimer interface [polypeptide binding]; other site
1036673018834	catalytic residue [active]
1036673018835	cobyric acid synthase; Provisional; Region: PRK00784
1036673018836	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
1036673018837	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1036673018838	catalytic triad [active]
1036673018839	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1036673018840	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
1036673018841	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
1036673018842	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1036673018843	homotrimer interface [polypeptide binding]; other site
1036673018844	Walker A motif; other site
1036673018845	GTP binding site [chemical binding]; other site
1036673018846	Walker B motif; other site
1036673018847	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1036673018848	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1036673018849	putative dimer interface [polypeptide binding]; other site
1036673018850	active site pocket [active]
1036673018851	putative cataytic base [active]
1036673018852	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1036673018853	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1036673018854	Walker A/P-loop; other site
1036673018855	ATP binding site [chemical binding]; other site
1036673018856	Q-loop/lid; other site
1036673018857	ABC transporter signature motif; other site
1036673018858	Walker B; other site
1036673018859	D-loop; other site
1036673018860	H-loop/switch region; other site
1036673018861	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1036673018862	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673018863	ABC-ATPase subunit  interface; other site
1036673018864	dimer interface [polypeptide binding]; other site
1036673018865	putative PBP binding regions; other site
1036673018866	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1036673018867	Periplasmic binding protein YvrC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria and archaea.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: YvrC; cd01143
1036673018868	putative binding site residues; other site
1036673018869	Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388
1036673018870	hypothetical protein; Validated; Region: PRK07682
1036673018871	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673018872	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673018873	homodimer interface [polypeptide binding]; other site
1036673018874	catalytic residue [active]
1036673018875	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1036673018876	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1036673018877	AsnC family; Region: AsnC_trans_reg; pfam01037
1036673018878	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1036673018879	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1036673018880	dimer interface [polypeptide binding]; other site
1036673018881	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673018882	catalytic residue [active]
1036673018883	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673018884	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673018885	putative substrate translocation pore; other site
1036673018886	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1036673018887	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
1036673018888	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1036673018889	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1036673018890	MutS domain III; Region: MutS_III; pfam05192
1036673018891	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1036673018892	Walker A/P-loop; other site
1036673018893	ATP binding site [chemical binding]; other site
1036673018894	Q-loop/lid; other site
1036673018895	ABC transporter signature motif; other site
1036673018896	Walker B; other site
1036673018897	D-loop; other site
1036673018898	H-loop/switch region; other site
1036673018899	Smr domain; Region: Smr; pfam01713
1036673018900	Membrane protein of unknown function; Region: DUF360; pfam04020
1036673018901	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1036673018902	classical (c) SDRs; Region: SDR_c; cd05233
1036673018903	NAD(P) binding site [chemical binding]; other site
1036673018904	active site
1036673018905	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673018906	DNA-binding site [nucleotide binding]; DNA binding site
1036673018907	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1036673018908	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673018909	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673018910	homodimer interface [polypeptide binding]; other site
1036673018911	catalytic residue [active]
1036673018912	Colicin V production protein; Region: Colicin_V; pfam02674
1036673018913	Cell division protein ZapA; Region: ZapA; cl01146
1036673018914	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1036673018915	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1036673018916	putative tRNA-binding site [nucleotide binding]; other site
1036673018917	B3/4 domain; Region: B3_4; pfam03483
1036673018918	tRNA synthetase B5 domain; Region: B5; pfam03484
1036673018919	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1036673018920	dimer interface [polypeptide binding]; other site
1036673018921	motif 1; other site
1036673018922	motif 3; other site
1036673018923	motif 2; other site
1036673018924	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1036673018925	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1036673018926	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1036673018927	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1036673018928	dimer interface [polypeptide binding]; other site
1036673018929	motif 1; other site
1036673018930	active site
1036673018931	motif 2; other site
1036673018932	motif 3; other site
1036673018933	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
1036673018934	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
1036673018935	Ferritin-like domain; Region: Ferritin; pfam00210
1036673018936	ferroxidase diiron center [ion binding]; other site
1036673018937	Protein of unknown function (DUF1450); Region: DUF1450; cl11488
1036673018938	RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4
1036673018939	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673018940	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673018941	DNA binding residues [nucleotide binding]
1036673018942	SnoaL-like domain; Region: SnoaL_2; pfam12680
1036673018943	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1036673018944	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1036673018945	PAS fold; Region: PAS; pfam00989
1036673018946	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673018947	putative active site [active]
1036673018948	heme pocket [chemical binding]; other site
1036673018949	PAS domain S-box; Region: sensory_box; TIGR00229
1036673018950	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673018951	putative active site [active]
1036673018952	heme pocket [chemical binding]; other site
1036673018953	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673018954	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673018955	metal binding site [ion binding]; metal-binding site
1036673018956	active site
1036673018957	I-site; other site
1036673018958	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1036673018959	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
1036673018960	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1036673018961	catalytic triad [active]
1036673018962	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
1036673018963	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
1036673018964	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
1036673018965	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1036673018966	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1036673018967	active site
1036673018968	SAM binding site [chemical binding]; other site
1036673018969	homodimer interface [polypeptide binding]; other site
1036673018970	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1036673018971	active site
1036673018972	SAM binding site [chemical binding]; other site
1036673018973	homodimer interface [polypeptide binding]; other site
1036673018974	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1036673018975	active site
1036673018976	putative homodimer interface [polypeptide binding]; other site
1036673018977	SAM binding site [chemical binding]; other site
1036673018978	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1036673018979	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
1036673018980	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
1036673018981	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
1036673018982	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1036673018983	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
1036673018984	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1036673018985	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1036673018986	putative active site [active]
1036673018987	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414
1036673018988	putative active site [active]
1036673018989	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1036673018990	active site
1036673018991	SAM binding site [chemical binding]; other site
1036673018992	homodimer interface [polypeptide binding]; other site
1036673018993	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
1036673018994	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1036673018995	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1036673018996	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1036673018997	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673018998	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673018999	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673019000	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673019001	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673019002	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673019003	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673019004	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673019005	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673019006	active site
1036673019007	catalytic tetrad [active]
1036673019008	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673019009	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673019010	metal binding site [ion binding]; metal-binding site
1036673019011	active site
1036673019012	I-site; other site
1036673019013	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673019014	CopC domain; Region: CopC; pfam04234
1036673019015	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07088
1036673019016	ATP cone domain; Region: ATP-cone; pfam03477
1036673019017	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1036673019018	active site
1036673019019	dimer interface [polypeptide binding]; other site
1036673019020	catalytic residues [active]
1036673019021	effector binding site; other site
1036673019022	R2 peptide binding site; other site
1036673019023	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1036673019024	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1036673019025	dimer interface [polypeptide binding]; other site
1036673019026	putative radical transfer pathway; other site
1036673019027	diiron center [ion binding]; other site
1036673019028	tyrosyl radical; other site
1036673019029	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1036673019030	putative binding surface; other site
1036673019031	active site
1036673019032	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673019033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673019034	active site
1036673019035	phosphorylation site [posttranslational modification]
1036673019036	intermolecular recognition site; other site
1036673019037	dimerization interface [polypeptide binding]; other site
1036673019038	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673019039	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673019040	metal binding site [ion binding]; metal-binding site
1036673019041	active site
1036673019042	I-site; other site
1036673019043	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673019044	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673019045	active site
1036673019046	phosphorylation site [posttranslational modification]
1036673019047	intermolecular recognition site; other site
1036673019048	dimerization interface [polypeptide binding]; other site
1036673019049	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673019050	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673019051	active site
1036673019052	phosphorylation site [posttranslational modification]
1036673019053	intermolecular recognition site; other site
1036673019054	dimerization interface [polypeptide binding]; other site
1036673019055	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1036673019056	putative active site pocket [active]
1036673019057	dimerization interface [polypeptide binding]; other site
1036673019058	putative catalytic residue [active]
1036673019059	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1036673019060	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1036673019061	putative active site [active]
1036673019062	Mor transcription activator family; Region: Mor; cl02360
1036673019063	Allophanate hydrolase subunit 2; Region: AHS2; cl00865
1036673019064	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1036673019065	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1036673019066	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1036673019067	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1036673019068	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1036673019069	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036673019070	active site
1036673019071	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1036673019072	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1036673019073	active site
1036673019074	metal binding site [ion binding]; metal-binding site
1036673019075	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1036673019076	ABC-type phosphate/phosphonate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PhnD; COG3221
1036673019077	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673019078	substrate binding pocket [chemical binding]; other site
1036673019079	membrane-bound complex binding site; other site
1036673019080	hinge residues; other site
1036673019081	Protein of unknown function (DUF342); Region: DUF342; pfam03961
1036673019082	threonine synthase; Validated; Region: PRK06260
1036673019083	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
1036673019084	homodimer interface [polypeptide binding]; other site
1036673019085	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673019086	catalytic residue [active]
1036673019087	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1036673019088	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1036673019089	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1036673019090	dimerization interface [polypeptide binding]; other site
1036673019091	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1036673019092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673019093	dimer interface [polypeptide binding]; other site
1036673019094	conserved gate region; other site
1036673019095	ABC-ATPase subunit interface; other site
1036673019096	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1036673019097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673019098	dimer interface [polypeptide binding]; other site
1036673019099	conserved gate region; other site
1036673019100	ABC-ATPase subunit interface; other site
1036673019101	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1036673019102	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1036673019103	Walker A/P-loop; other site
1036673019104	ATP binding site [chemical binding]; other site
1036673019105	Q-loop/lid; other site
1036673019106	ABC transporter signature motif; other site
1036673019107	Walker B; other site
1036673019108	D-loop; other site
1036673019109	H-loop/switch region; other site
1036673019110	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
1036673019111	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1036673019112	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1036673019113	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1036673019114	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1036673019115	Walker A/P-loop; other site
1036673019116	ATP binding site [chemical binding]; other site
1036673019117	Q-loop/lid; other site
1036673019118	ABC transporter signature motif; other site
1036673019119	Walker B; other site
1036673019120	D-loop; other site
1036673019121	H-loop/switch region; other site
1036673019122	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
1036673019123	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1036673019124	active site
1036673019125	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673019126	3D domain; Region: 3D; cl01439
1036673019127	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1036673019128	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1036673019129	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1036673019130	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673019131	putative active site [active]
1036673019132	heme pocket [chemical binding]; other site
1036673019133	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673019134	ATP binding site [chemical binding]; other site
1036673019135	Mg2+ binding site [ion binding]; other site
1036673019136	G-X-G motif; other site
1036673019137	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
1036673019138	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673019139	active site
1036673019140	phosphorylation site [posttranslational modification]
1036673019141	intermolecular recognition site; other site
1036673019142	dimerization interface [polypeptide binding]; other site
1036673019143	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
1036673019144	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1036673019145	C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663
1036673019146	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1036673019147	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1036673019148	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1036673019149	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
1036673019150	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673019151	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673019152	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673019153	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673019154	lysine transporter; Provisional; Region: PRK10836
1036673019155	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1036673019156	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1036673019157	active site
1036673019158	multimer interface [polypeptide binding]; other site
1036673019159	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1036673019160	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1036673019161	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1036673019162	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1036673019163	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1036673019164	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1036673019165	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1036673019166	active site
1036673019167	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1036673019168	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1036673019169	Walker A/P-loop; other site
1036673019170	ATP binding site [chemical binding]; other site
1036673019171	Q-loop/lid; other site
1036673019172	ABC transporter signature motif; other site
1036673019173	Walker B; other site
1036673019174	D-loop; other site
1036673019175	H-loop/switch region; other site
1036673019176	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
1036673019177	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
1036673019178	hypothetical protein; Provisional; Region: PRK06185
1036673019179	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1036673019180	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1036673019181	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1036673019182	catalytic site [active]
1036673019183	PrcB C-terminal; Region: PrcB_C; pfam14343
1036673019184	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
1036673019185	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1036673019186	putative ligand binding site [chemical binding]; other site
1036673019187	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1036673019188	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1036673019189	Walker A/P-loop; other site
1036673019190	ATP binding site [chemical binding]; other site
1036673019191	Q-loop/lid; other site
1036673019192	ABC transporter signature motif; other site
1036673019193	Walker B; other site
1036673019194	D-loop; other site
1036673019195	H-loop/switch region; other site
1036673019196	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1036673019197	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673019198	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1036673019199	TM-ABC transporter signature motif; other site
1036673019200	Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129
1036673019201	putative active site [active]
1036673019202	putative catalytic site [active]
1036673019203	Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130
1036673019204	PLD-like domain; Region: PLDc_2; pfam13091
1036673019205	putative active site [active]
1036673019206	putative catalytic site [active]
1036673019207	Peptidase family M23; Region: Peptidase_M23; pfam01551
1036673019208	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1036673019209	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1036673019210	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673019211	dimer interface [polypeptide binding]; other site
1036673019212	conserved gate region; other site
1036673019213	putative PBP binding loops; other site
1036673019214	ABC-ATPase subunit interface; other site
1036673019215	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1036673019216	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673019217	dimer interface [polypeptide binding]; other site
1036673019218	conserved gate region; other site
1036673019219	putative PBP binding loops; other site
1036673019220	ABC-ATPase subunit interface; other site
1036673019221	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1036673019222	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673019223	substrate binding pocket [chemical binding]; other site
1036673019224	membrane-bound complex binding site; other site
1036673019225	hinge residues; other site
1036673019226	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1036673019227	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1036673019228	Walker A/P-loop; other site
1036673019229	ATP binding site [chemical binding]; other site
1036673019230	Q-loop/lid; other site
1036673019231	ABC transporter signature motif; other site
1036673019232	Walker B; other site
1036673019233	D-loop; other site
1036673019234	H-loop/switch region; other site
1036673019235	S-layer homology domain; Region: SLH; pfam00395
1036673019236	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
1036673019237	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1036673019238	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
1036673019239	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1036673019240	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1036673019241	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1036673019242	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673019243	putative active site [active]
1036673019244	heme pocket [chemical binding]; other site
1036673019245	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673019246	dimer interface [polypeptide binding]; other site
1036673019247	phosphorylation site [posttranslational modification]
1036673019248	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673019249	ATP binding site [chemical binding]; other site
1036673019250	Mg2+ binding site [ion binding]; other site
1036673019251	G-X-G motif; other site
1036673019252	Mitochondrial biogenesis AIM24; Region: AIM24; cl00884
1036673019253	Protein of unknown function (DUF458); Region: DUF458; pfam04308
1036673019254	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
1036673019255	active site
1036673019256	zinc binding site [ion binding]; other site
1036673019257	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1036673019258	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1036673019259	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1036673019260	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1036673019261	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673019262	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673019263	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673019264	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673019265	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673019266	dimer interface [polypeptide binding]; other site
1036673019267	conserved gate region; other site
1036673019268	putative PBP binding loops; other site
1036673019269	ABC-ATPase subunit interface; other site
1036673019270	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673019271	dimer interface [polypeptide binding]; other site
1036673019272	conserved gate region; other site
1036673019273	putative PBP binding loops; other site
1036673019274	ABC-ATPase subunit interface; other site
1036673019275	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673019276	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673019277	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673019278	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673019279	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673019280	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673019281	Histidine kinase; Region: His_kinase; pfam06580
1036673019282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673019283	ATP binding site [chemical binding]; other site
1036673019284	Mg2+ binding site [ion binding]; other site
1036673019285	G-X-G motif; other site
1036673019286	YheO-like PAS domain; Region: PAS_6; pfam08348
1036673019287	HTH domain; Region: HTH_22; pfam13309
1036673019288	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1036673019289	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
1036673019290	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1036673019291	catalytic residue [active]
1036673019292	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
1036673019293	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
1036673019294	active site
1036673019295	putative substrate binding pocket [chemical binding]; other site
1036673019296	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1036673019297	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1036673019298	homotrimer interaction site [polypeptide binding]; other site
1036673019299	putative active site [active]
1036673019300	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673019301	Coenzyme A binding pocket [chemical binding]; other site
1036673019302	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
1036673019303	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1036673019304	Phosphotransferase enzyme family; Region: APH; pfam01636
1036673019305	substrate binding site [chemical binding]; other site
1036673019306	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1036673019307	Phosphotransferase enzyme family; Region: APH; pfam01636
1036673019308	active site
1036673019309	substrate binding site [chemical binding]; other site
1036673019310	ATP binding site [chemical binding]; other site
1036673019311	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1036673019312	putative active site [active]
1036673019313	putative metal binding site [ion binding]; other site
1036673019314	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1036673019315	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1036673019316	FAD binding domain; Region: FAD_binding_3; pfam01494
1036673019317	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1036673019318	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
1036673019319	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673019320	nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095
1036673019321	FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860
1036673019322	active site
1036673019323	non-prolyl cis peptide bond; other site
1036673019324	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1036673019325	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673019326	dimer interface [polypeptide binding]; other site
1036673019327	conserved gate region; other site
1036673019328	putative PBP binding loops; other site
1036673019329	ABC-ATPase subunit interface; other site
1036673019330	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1036673019331	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1036673019332	Walker A/P-loop; other site
1036673019333	ATP binding site [chemical binding]; other site
1036673019334	Q-loop/lid; other site
1036673019335	ABC transporter signature motif; other site
1036673019336	Walker B; other site
1036673019337	D-loop; other site
1036673019338	H-loop/switch region; other site
1036673019339	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1036673019340	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1036673019341	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1036673019342	dimer interface [polypeptide binding]; other site
1036673019343	FMN binding site [chemical binding]; other site
1036673019344	NADPH bind site [chemical binding]; other site
1036673019345	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1036673019346	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1036673019347	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
1036673019348	active site
1036673019349	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
1036673019350	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1036673019351	Fn3 associated; Region: Fn3_assoc; pfam13287
1036673019352	Fn3 associated; Region: Fn3_assoc; pfam13287
1036673019353	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1036673019354	Fn3 associated; Region: Fn3_assoc; pfam13287
1036673019355	Fn3 associated; Region: Fn3_assoc; pfam13287
1036673019356	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673019357	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673019358	active site
1036673019359	phosphorylation site [posttranslational modification]
1036673019360	intermolecular recognition site; other site
1036673019361	dimerization interface [polypeptide binding]; other site
1036673019362	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673019363	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673019364	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673019365	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673019366	dimerization interface [polypeptide binding]; other site
1036673019367	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673019368	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673019369	dimer interface [polypeptide binding]; other site
1036673019370	putative CheW interface [polypeptide binding]; other site
1036673019371	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1036673019372	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673019373	TM-ABC transporter signature motif; other site
1036673019374	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1036673019375	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1036673019376	Walker A/P-loop; other site
1036673019377	ATP binding site [chemical binding]; other site
1036673019378	Q-loop/lid; other site
1036673019379	ABC transporter signature motif; other site
1036673019380	Walker B; other site
1036673019381	D-loop; other site
1036673019382	H-loop/switch region; other site
1036673019383	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1036673019384	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
1036673019385	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
1036673019386	ligand binding site [chemical binding]; other site
1036673019387	calcium binding site [ion binding]; other site
1036673019388	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
1036673019389	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1036673019390	putative ligand binding site [chemical binding]; other site
1036673019391	Cache domain; Region: Cache_1; pfam02743
1036673019392	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673019393	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673019394	dimerization interface [polypeptide binding]; other site
1036673019395	Histidine kinase; Region: His_kinase; pfam06580
1036673019396	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673019397	ATP binding site [chemical binding]; other site
1036673019398	Mg2+ binding site [ion binding]; other site
1036673019399	G-X-G motif; other site
1036673019400	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673019401	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673019402	active site
1036673019403	phosphorylation site [posttranslational modification]
1036673019404	intermolecular recognition site; other site
1036673019405	dimerization interface [polypeptide binding]; other site
1036673019406	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673019407	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673019408	TIGR02452 family protein; Region: TIGR02452
1036673019409	Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021
1036673019410	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
1036673019411	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
1036673019412	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1036673019413	active site
1036673019414	nucleotide binding site [chemical binding]; other site
1036673019415	HIGH motif; other site
1036673019416	KMSKS motif; other site
1036673019417	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
1036673019418	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
1036673019419	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1036673019420	nudix motif; other site
1036673019421	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
1036673019422	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1036673019423	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
1036673019424	Leucine rich repeat; Region: LRR_8; pfam13855
1036673019425	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673019426	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1036673019427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1036673019428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1036673019429	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673019430	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1036673019431	Walker A motif; other site
1036673019432	ATP binding site [chemical binding]; other site
1036673019433	Walker B motif; other site
1036673019434	arginine finger; other site
1036673019435	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
1036673019436	tellurium resistance terB-like protein; Region: terB_like; cd07177
1036673019437	metal binding site [ion binding]; metal-binding site
1036673019438	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1036673019439	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1036673019440	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1036673019441	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673019442	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242
1036673019443	putative dimer interface [polypeptide binding]; other site
1036673019444	ligand binding site [chemical binding]; other site
1036673019445	Zn binding site [ion binding]; other site
1036673019446	Conserved protein containing a Zn-ribbon-like motif, possibly RNA-binding [General function prediction only]; Region: COG5516
1036673019447	Protein of unknown function (DUF1470); Region: DUF1470; pfam07336
1036673019448	CGNR zinc finger; Region: zf-CGNR; pfam11706
1036673019449	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673019450	PAS domain; Region: PAS_9; pfam13426
1036673019451	putative active site [active]
1036673019452	heme pocket [chemical binding]; other site
1036673019453	PAS domain S-box; Region: sensory_box; TIGR00229
1036673019454	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673019455	putative active site [active]
1036673019456	heme pocket [chemical binding]; other site
1036673019457	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673019458	PAS fold; Region: PAS_3; pfam08447
1036673019459	putative active site [active]
1036673019460	heme pocket [chemical binding]; other site
1036673019461	PAS domain S-box; Region: sensory_box; TIGR00229
1036673019462	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673019463	putative active site [active]
1036673019464	heme pocket [chemical binding]; other site
1036673019465	PAS domain S-box; Region: sensory_box; TIGR00229
1036673019466	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673019467	putative active site [active]
1036673019468	heme pocket [chemical binding]; other site
1036673019469	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1036673019470	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673019471	putative active site [active]
1036673019472	heme pocket [chemical binding]; other site
1036673019473	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673019474	dimer interface [polypeptide binding]; other site
1036673019475	phosphorylation site [posttranslational modification]
1036673019476	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673019477	ATP binding site [chemical binding]; other site
1036673019478	Mg2+ binding site [ion binding]; other site
1036673019479	G-X-G motif; other site
1036673019480	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673019481	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673019482	active site
1036673019483	phosphorylation site [posttranslational modification]
1036673019484	intermolecular recognition site; other site
1036673019485	dimerization interface [polypeptide binding]; other site
1036673019486	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1036673019487	phosphate binding site [ion binding]; other site
1036673019488	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1036673019489	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1036673019490	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1036673019491	DNA binding residues [nucleotide binding]
1036673019492	Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179
1036673019493	Predicted transcriptional regulators [Transcription]; Region: COG1695
1036673019494	Transcriptional regulator PadR-like family; Region: PadR; cl17335
1036673019495	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673019496	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673019497	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673019498	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673019499	metal binding site [ion binding]; metal-binding site
1036673019500	active site
1036673019501	I-site; other site
1036673019502	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673019503	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1036673019504	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1036673019505	Heat induced stress protein YflT; Region: YflT; pfam11181
1036673019506	conserved domain; Region: TIGR02271
1036673019507	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1036673019508	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1036673019509	protein binding site [polypeptide binding]; other site
1036673019510	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1036673019511	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673019512	ABC-ATPase subunit  interface; other site
1036673019513	dimer interface [polypeptide binding]; other site
1036673019514	putative PBP binding regions; other site
1036673019515	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1036673019516	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673019517	ABC-ATPase subunit  interface; other site
1036673019518	dimer interface [polypeptide binding]; other site
1036673019519	putative PBP binding regions; other site
1036673019520	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1036673019521	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1036673019522	intersubunit interface [polypeptide binding]; other site
1036673019523	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673019524	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673019525	metal binding site [ion binding]; metal-binding site
1036673019526	active site
1036673019527	I-site; other site
1036673019528	Fic family protein [Function unknown]; Region: COG3177
1036673019529	Fic/DOC family; Region: Fic; pfam02661
1036673019530	MarR family; Region: MarR_2; cl17246
1036673019531	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
1036673019532	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1036673019533	P loop; other site
1036673019534	Nucleotide binding site [chemical binding]; other site
1036673019535	DTAP/Switch II; other site
1036673019536	Switch I; other site
1036673019537	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
1036673019538	bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595
1036673019539	Chorismate mutase type II; Region: CM_2; cl00693
1036673019540	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
1036673019541	probable F420-dependent oxidoreductase, MSMEG_4141 family; Region: F420_MSMEG_4141; TIGR03620
1036673019542	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347
1036673019543	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1036673019544	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673019545	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673019546	active site
1036673019547	catalytic tetrad [active]
1036673019548	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673019549	Coenzyme A binding pocket [chemical binding]; other site
1036673019550	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673019551	Coenzyme A binding pocket [chemical binding]; other site
1036673019552	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
1036673019553	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
1036673019554	dimer interface [polypeptide binding]; other site
1036673019555	active site
1036673019556	metal binding site [ion binding]; metal-binding site
1036673019557	UDP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: COG4284
1036673019558	UDPGlcNAc pyrophosphorylase catalayzes the synthesis of UDPGlcNAc; Region: UDPGlcNAc_PPase; cd04193
1036673019559	substrate binding site; other site
1036673019560	dimerization interface; other site
1036673019561	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673019562	Coenzyme A binding pocket [chemical binding]; other site
1036673019563	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1036673019564	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036673019565	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036673019566	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673019567	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1036673019568	substrate binding site [chemical binding]; other site
1036673019569	Mrr N-terminal domain; Region: Mrr_N; pfam14338
1036673019570	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1036673019571	Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040
1036673019572	Competence protein J (ComJ); Region: ComJ; pfam11033
1036673019573	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1036673019574	Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750
1036673019575	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673019576	Interdomain contacts; other site
1036673019577	Cytokine receptor motif; other site
1036673019578	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673019579	Interdomain contacts; other site
1036673019580	Cytokine receptor motif; other site
1036673019581	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1036673019582	dockerin binding interface; other site
1036673019583	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271
1036673019584	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1036673019585	putative NAD(P) binding site [chemical binding]; other site
1036673019586	substrate binding site [chemical binding]; other site
1036673019587	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
1036673019588	iron-sulfur cluster [ion binding]; other site
1036673019589	[2Fe-2S] cluster binding site [ion binding]; other site
1036673019590	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1036673019591	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169
1036673019592	conserved cys residue [active]
1036673019593	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673019594	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673019595	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673019596	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673019597	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673019598	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673019599	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673019600	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673019601	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415
1036673019602	Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540
1036673019603	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1036673019604	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1036673019605	Metal-binding active site; metal-binding site
1036673019606	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1036673019607	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673019608	acyl carrier protein; Provisional; Region: PRK07639
1036673019609	acyl-CoA synthetase; Validated; Region: PRK08308
1036673019610	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1036673019611	AMP binding site [chemical binding]; other site
1036673019612	active site
1036673019613	acyl-activating enzyme (AAE) consensus motif; other site
1036673019614	CoA binding site [chemical binding]; other site
1036673019615	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1036673019616	IucA / IucC family; Region: IucA_IucC; pfam04183
1036673019617	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1036673019618	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673019619	Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486
1036673019620	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1036673019621	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1036673019622	IucA / IucC family; Region: IucA_IucC; pfam04183
1036673019623	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1036673019624	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
1036673019625	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673019626	catalytic residue [active]
1036673019627	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
1036673019628	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036673019629	inhibitor-cofactor binding pocket; inhibition site
1036673019630	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673019631	catalytic residue [active]
1036673019632	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1036673019633	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1036673019634	siderophore binding site; other site
1036673019635	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1036673019636	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1036673019637	Walker A/P-loop; other site
1036673019638	ATP binding site [chemical binding]; other site
1036673019639	Q-loop/lid; other site
1036673019640	ABC transporter signature motif; other site
1036673019641	Walker B; other site
1036673019642	D-loop; other site
1036673019643	H-loop/switch region; other site
1036673019644	DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402
1036673019645	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673019646	DNA-binding site [nucleotide binding]; DNA binding site
1036673019647	UTRA domain; Region: UTRA; pfam07702
1036673019648	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1036673019649	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1036673019650	substrate binding site [chemical binding]; other site
1036673019651	ATP binding site [chemical binding]; other site
1036673019652	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1036673019653	A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710
1036673019654	putative active site [active]
1036673019655	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
1036673019656	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
1036673019657	fructoselysine 3-epimerase; Provisional; Region: PRK09856
1036673019658	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1036673019659	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
1036673019660	oligomer interface [polypeptide binding]; other site
1036673019661	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
1036673019662	Protein of unknown function (DUF458); Region: DUF458; cl00861
1036673019663	NAD-dependent deacetylase; Provisional; Region: PRK00481
1036673019664	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
1036673019665	NAD+ binding site [chemical binding]; other site
1036673019666	substrate binding site [chemical binding]; other site
1036673019667	Zn binding site [ion binding]; other site
1036673019668	xylose isomerase; Provisional; Region: PRK05474
1036673019669	xylose isomerase; Region: xylose_isom_A; TIGR02630
1036673019670	DinB superfamily; Region: DinB_2; pfam12867
1036673019671	DinB family; Region: DinB; cl17821
1036673019672	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1036673019673	Domain of unknown function (DUF2935); Region: DUF2935; pfam11155
1036673019674	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673019675	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673019676	active site
1036673019677	phosphorylation site [posttranslational modification]
1036673019678	intermolecular recognition site; other site
1036673019679	dimerization interface [polypeptide binding]; other site
1036673019680	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673019681	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673019682	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673019683	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1036673019684	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673019685	dimerization interface [polypeptide binding]; other site
1036673019686	Histidine kinase; Region: His_kinase; pfam06580
1036673019687	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673019688	ATP binding site [chemical binding]; other site
1036673019689	Mg2+ binding site [ion binding]; other site
1036673019690	G-X-G motif; other site
1036673019691	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673019692	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673019693	dimer interface [polypeptide binding]; other site
1036673019694	conserved gate region; other site
1036673019695	putative PBP binding loops; other site
1036673019696	ABC-ATPase subunit interface; other site
1036673019697	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1036673019698	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673019699	dimer interface [polypeptide binding]; other site
1036673019700	conserved gate region; other site
1036673019701	putative PBP binding loops; other site
1036673019702	ABC-ATPase subunit interface; other site
1036673019703	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673019704	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673019705	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673019706	active site
1036673019707	catalytic tetrad [active]
1036673019708	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1036673019709	SWIM zinc finger; Region: SWIM; pfam04434
1036673019710	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
1036673019711	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673019712	dimer interface [polypeptide binding]; other site
1036673019713	conserved gate region; other site
1036673019714	putative PBP binding loops; other site
1036673019715	ABC-ATPase subunit interface; other site
1036673019716	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1036673019717	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673019718	substrate binding pocket [chemical binding]; other site
1036673019719	membrane-bound complex binding site; other site
1036673019720	hinge residues; other site
1036673019721	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673019722	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673019723	DNA binding residues [nucleotide binding]
1036673019724	dimerization interface [polypeptide binding]; other site
1036673019725	Integral membrane protein DUF95; Region: DUF95; pfam01944
1036673019726	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1036673019727	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1036673019728	Walker A/P-loop; other site
1036673019729	ATP binding site [chemical binding]; other site
1036673019730	Q-loop/lid; other site
1036673019731	ABC transporter signature motif; other site
1036673019732	Walker B; other site
1036673019733	D-loop; other site
1036673019734	H-loop/switch region; other site
1036673019735	Yip1 domain; Region: Yip1; pfam04893
1036673019736	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1036673019737	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036673019738	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1036673019739	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1036673019740	FtsX-like permease family; Region: FtsX; pfam02687
1036673019741	Transposase domain (DUF772); Region: DUF772; pfam05598
1036673019742	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1036673019743	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1036673019744	Nuclease-related domain; Region: NERD; pfam08378
1036673019745	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673019746	ATP binding site [chemical binding]; other site
1036673019747	putative Mg++ binding site [ion binding]; other site
1036673019748	Family description; Region: UvrD_C_2; pfam13538
1036673019749	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
1036673019750	active site
1036673019751	NTP binding site [chemical binding]; other site
1036673019752	metal binding triad [ion binding]; metal-binding site
1036673019753	antibiotic binding site [chemical binding]; other site
1036673019754	DNA phosphorothioation-dependent restriction protein DptH; Region: dnd_assoc_2; TIGR03237
1036673019755	AAA-like domain; Region: AAA_10; pfam12846
1036673019756	DNA phosphorothioation-dependent restriction protein DptG; Region: dnd_assoc_1; TIGR03236
1036673019757	DNA phosphorothioation-dependent restriction protein DptF; Region: dnd_assoc_3; TIGR03238
1036673019758	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1036673019759	cysteine desulfurase DndA; Region: DNA_S_dndA; TIGR03235
1036673019760	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036673019761	catalytic residue [active]
1036673019762	DNA sulfur modification protein DndD; Region: DNA_S_dndD; TIGR03185
1036673019763	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673019764	Walker A/P-loop; other site
1036673019765	ATP binding site [chemical binding]; other site
1036673019766	Protein of unknown function (DUF4239); Region: DUF4239; pfam14023
1036673019767	putative sulfurtransferase DndC; Region: DNA_S_dndC; TIGR03183
1036673019768	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1036673019769	Active Sites [active]
1036673019770	DNA-sulfur modification-associated; Region: DndB; cl17621
1036673019771	DGQHR domain; Region: DGQHR; TIGR03187
1036673019772	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673019773	Walker A motif; other site
1036673019774	ATP binding site [chemical binding]; other site
1036673019775	Walker B motif; other site
1036673019776	arginine finger; other site
1036673019777	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1036673019778	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1036673019779	Peptidases of the G1 family and homologs that might lack peptidase activity; Region: Peptidase_G1_like; cl03371
1036673019780	BAX inhibitor (BI)-1/YccA-like protein family; Region: BI-1-like; cl00473
1036673019781	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673019782	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673019783	dimer interface [polypeptide binding]; other site
1036673019784	phosphorylation site [posttranslational modification]
1036673019785	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673019786	ATP binding site [chemical binding]; other site
1036673019787	Mg2+ binding site [ion binding]; other site
1036673019788	G-X-G motif; other site
1036673019789	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673019790	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673019791	active site
1036673019792	phosphorylation site [posttranslational modification]
1036673019793	intermolecular recognition site; other site
1036673019794	dimerization interface [polypeptide binding]; other site
1036673019795	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1036673019796	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1036673019797	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1036673019798	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1036673019799	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1036673019800	A pre-toxin domain with the TG motif; Region: PT-TG; pfam14449
1036673019801	Proteins of 100 residues with WXG; Region: WXG100; cl02005
1036673019802	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
1036673019803	AAA domain; Region: AAA_30; pfam13604
1036673019804	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
1036673019805	AAA domain; Region: AAA_12; pfam13087
1036673019806	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1036673019807	PLD-like domain; Region: PLDc_2; pfam13091
1036673019808	putative active site [active]
1036673019809	catalytic site [active]
1036673019810	Fic family protein [Function unknown]; Region: COG3177
1036673019811	Fic/DOC family; Region: Fic; pfam02661
1036673019812	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1036673019813	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
1036673019814	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
1036673019815	DNA interaction; other site
1036673019816	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1036673019817	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1036673019818	active site
1036673019819	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
1036673019820	putative metal binding site; other site
1036673019821	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1036673019822	active site
1036673019823	RNA 2'-phosphotransferase; Reviewed; Region: PRK00819
1036673019824	RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859
1036673019825	Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127
1036673019826	TROVE domain; Region: TROVE; pfam05731
1036673019827	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1036673019828	metal ion-dependent adhesion site (MIDAS); other site
1036673019829	WYL domain; Region: WYL; pfam13280
1036673019830	WYL domain; Region: WYL; pfam13280
1036673019831	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1036673019832	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1036673019833	ring oligomerisation interface [polypeptide binding]; other site
1036673019834	ATP/Mg binding site [chemical binding]; other site
1036673019835	stacking interactions; other site
1036673019836	hinge regions; other site
1036673019837	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1036673019838	oligomerisation interface [polypeptide binding]; other site
1036673019839	mobile loop; other site
1036673019840	roof hairpin; other site
1036673019841	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1036673019842	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
1036673019843	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1036673019844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673019845	dimer interface [polypeptide binding]; other site
1036673019846	conserved gate region; other site
1036673019847	putative PBP binding loops; other site
1036673019848	ABC-ATPase subunit interface; other site
1036673019849	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1036673019850	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673019851	dimer interface [polypeptide binding]; other site
1036673019852	conserved gate region; other site
1036673019853	putative PBP binding loops; other site
1036673019854	ABC-ATPase subunit interface; other site
1036673019855	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1036673019856	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673019857	Walker A/P-loop; other site
1036673019858	ATP binding site [chemical binding]; other site
1036673019859	Q-loop/lid; other site
1036673019860	ABC transporter signature motif; other site
1036673019861	Walker B; other site
1036673019862	D-loop; other site
1036673019863	H-loop/switch region; other site
1036673019864	TOBE domain; Region: TOBE_2; pfam08402
1036673019865	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673019866	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1036673019867	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1036673019868	Walker A/P-loop; other site
1036673019869	ATP binding site [chemical binding]; other site
1036673019870	Q-loop/lid; other site
1036673019871	ABC transporter signature motif; other site
1036673019872	Walker B; other site
1036673019873	D-loop; other site
1036673019874	H-loop/switch region; other site
1036673019875	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673019876	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673019877	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673019878	Walker A/P-loop; other site
1036673019879	ATP binding site [chemical binding]; other site
1036673019880	Q-loop/lid; other site
1036673019881	ABC transporter signature motif; other site
1036673019882	Walker B; other site
1036673019883	D-loop; other site
1036673019884	H-loop/switch region; other site
1036673019885	LysE type translocator; Region: LysE; cl00565
1036673019886	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1036673019887	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1036673019888	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1036673019889	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1036673019890	active site
1036673019891	dimer interface [polypeptide binding]; other site
1036673019892	motif 1; other site
1036673019893	motif 2; other site
1036673019894	motif 3; other site
1036673019895	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1036673019896	anticodon binding site; other site
1036673019897	amidase; Provisional; Region: PRK06828
1036673019898	Amidase; Region: Amidase; cl11426
1036673019899	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1036673019900	S-layer homology domain; Region: SLH; pfam00395
1036673019901	TraX protein; Region: TraX; cl05434
1036673019902	cytochrome o ubiquinol oxidase subunit IV; Region: CyoD; TIGR02847
1036673019903	Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863
1036673019904	Subunit I/III interface [polypeptide binding]; other site
1036673019905	Subunit III/IV interface [polypeptide binding]; other site
1036673019906	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
1036673019907	Ubiquinol oxidase subunit I.  Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane.  It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662
1036673019908	D-pathway; other site
1036673019909	Putative ubiquinol binding site [chemical binding]; other site
1036673019910	Low-spin heme (heme b) binding site [chemical binding]; other site
1036673019911	Putative water exit pathway; other site
1036673019912	Binuclear center (heme o3/CuB) [ion binding]; other site
1036673019913	K-pathway; other site
1036673019914	Putative proton exit pathway; other site
1036673019915	cytochrome o ubiquinol oxidase subunit II; Region: CyoA; TIGR01433
1036673019916	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1036673019917	COX Aromatic Rich Motif; Region: COX_ARM; pfam06481
1036673019918	Pectinesterase; Region: Pectinesterase; pfam01095
1036673019919	putative pectinesterase; Region: PLN02432; cl01911
1036673019920	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1036673019921	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1036673019922	catalytic residues [active]
1036673019923	dimer interface [polypeptide binding]; other site
1036673019924	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
1036673019925	rhamnose ABC transporter, rhamnose-binding protein; Region: RhaS; TIGR02637
1036673019926	ligand binding site [chemical binding]; other site
1036673019927	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1036673019928	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673019929	TM-ABC transporter signature motif; other site
1036673019930	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673019931	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1036673019932	TM-ABC transporter signature motif; other site
1036673019933	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1036673019934	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1036673019935	Walker A/P-loop; other site
1036673019936	ATP binding site [chemical binding]; other site
1036673019937	Q-loop/lid; other site
1036673019938	ABC transporter signature motif; other site
1036673019939	Walker B; other site
1036673019940	D-loop; other site
1036673019941	H-loop/switch region; other site
1036673019942	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1036673019943	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1036673019944	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1036673019945	Walker A/P-loop; other site
1036673019946	ATP binding site [chemical binding]; other site
1036673019947	Q-loop/lid; other site
1036673019948	ABC transporter signature motif; other site
1036673019949	Walker B; other site
1036673019950	D-loop; other site
1036673019951	H-loop/switch region; other site
1036673019952	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1036673019953	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1036673019954	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1036673019955	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1036673019956	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1036673019957	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1036673019958	DNA binding residues [nucleotide binding]
1036673019959	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1036673019960	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1036673019961	DNA binding residues [nucleotide binding]
1036673019962	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836
1036673019963	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1036673019964	Cache domain; Region: Cache_1; pfam02743
1036673019965	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673019966	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673019967	metal binding site [ion binding]; metal-binding site
1036673019968	active site
1036673019969	I-site; other site
1036673019970	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
1036673019971	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
1036673019972	putative metal binding site [ion binding]; other site
1036673019973	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1036673019974	active site
1036673019975	DoxX; Region: DoxX; pfam07681
1036673019976	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673019977	sequence-specific DNA binding site [nucleotide binding]; other site
1036673019978	salt bridge; other site
1036673019979	Cupin domain; Region: Cupin_2; pfam07883
1036673019980	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673019981	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673019982	ATP binding site [chemical binding]; other site
1036673019983	Mg2+ binding site [ion binding]; other site
1036673019984	G-X-G motif; other site
1036673019985	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673019986	Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390
1036673019987	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673019988	phosphorylation site [posttranslational modification]
1036673019989	dimer interface [polypeptide binding]; other site
1036673019990	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673019991	ATP binding site [chemical binding]; other site
1036673019992	Mg2+ binding site [ion binding]; other site
1036673019993	G-X-G motif; other site
1036673019994	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
1036673019995	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1036673019996	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1036673019997	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
1036673019998	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1036673019999	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1036673020000	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1036673020001	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
1036673020002	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1036673020003	Walker A motif; other site
1036673020004	ATP binding site [chemical binding]; other site
1036673020005	Walker B motif; other site
1036673020006	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
1036673020007	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1036673020008	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
1036673020009	Walker A motif; other site
1036673020010	ATP binding site [chemical binding]; other site
1036673020011	Walker B motif; other site
1036673020012	Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492
1036673020013	Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368
1036673020014	Bacterial Ig-like domain 2; Region: BID_2; smart00635
1036673020015	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544
1036673020016	NAD-dependent deacetylase; Provisional; Region: PRK00481
1036673020017	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
1036673020018	NAD+ binding site [chemical binding]; other site
1036673020019	substrate binding site [chemical binding]; other site
1036673020020	Zn binding site [ion binding]; other site
1036673020021	pullulanase, type I; Region: pulA_typeI; TIGR02104
1036673020022	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1036673020023	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1036673020024	Ca binding site [ion binding]; other site
1036673020025	active site
1036673020026	catalytic site [active]
1036673020027	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1036673020028	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1036673020029	tetramer interface [polypeptide binding]; other site
1036673020030	heme binding pocket [chemical binding]; other site
1036673020031	NADPH binding site [chemical binding]; other site
1036673020032	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673020033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673020034	active site
1036673020035	phosphorylation site [posttranslational modification]
1036673020036	intermolecular recognition site; other site
1036673020037	dimerization interface [polypeptide binding]; other site
1036673020038	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673020039	DNA binding residues [nucleotide binding]
1036673020040	dimerization interface [polypeptide binding]; other site
1036673020041	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1036673020042	TspO/MBR family; Region: TspO_MBR; cl01379
1036673020043	Histidine kinase; Region: HisKA_3; pfam07730
1036673020044	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673020045	ATP binding site [chemical binding]; other site
1036673020046	Mg2+ binding site [ion binding]; other site
1036673020047	G-X-G motif; other site
1036673020048	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1036673020049	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
1036673020050	putative di-iron ligands [ion binding]; other site
1036673020051	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1036673020052	active site
1036673020053	Glycosyl hydrolase family 43; Region: GH43_1; cd08980
1036673020054	active site
1036673020055	Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652
1036673020056	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161
1036673020057	putative sugar binding sites [chemical binding]; other site
1036673020058	Q-X-W motif; other site
1036673020059	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1036673020060	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1036673020061	Restriction endonuclease; Region: Mrr_cat; pfam04471
1036673020062	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
1036673020063	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673020064	putative active site [active]
1036673020065	putative metal binding site [ion binding]; other site
1036673020066	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
1036673020067	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673020068	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673020069	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673020070	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673020071	putative substrate translocation pore; other site
1036673020072	Suppressor of fused protein (SUFU); Region: SUFU; pfam05076
1036673020073	HEAT repeats; Region: HEAT_2; pfam13646
1036673020074	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1036673020075	nudix motif; other site
1036673020076	23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479
1036673020077	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673020078	S-adenosylmethionine binding site [chemical binding]; other site
1036673020079	putative lipid kinase; Reviewed; Region: PRK13337
1036673020080	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1036673020081	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1036673020082	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1036673020083	putative active site [active]
1036673020084	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1036673020085	putative active site [active]
1036673020086	TrpR-related protein YerC/YecD; Region: yecD_yerC; TIGR02531
1036673020087	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1036673020088	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1036673020089	active site
1036673020090	FMN binding site [chemical binding]; other site
1036673020091	substrate binding site [chemical binding]; other site
1036673020092	homotetramer interface [polypeptide binding]; other site
1036673020093	catalytic residue [active]
1036673020094	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
1036673020095	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673020096	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673020097	dimer interface [polypeptide binding]; other site
1036673020098	phosphorylation site [posttranslational modification]
1036673020099	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673020100	ATP binding site [chemical binding]; other site
1036673020101	Mg2+ binding site [ion binding]; other site
1036673020102	G-X-G motif; other site
1036673020103	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1036673020104	conserved cys residue [active]
1036673020105	Cupin domain; Region: Cupin_2; pfam07883
1036673020106	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673020107	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673020108	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1036673020109	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673020110	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673020111	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673020112	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673020113	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673020114	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673020115	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673020116	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
1036673020117	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673020118	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673020119	DNA binding residues [nucleotide binding]
1036673020120	Predicted membrane protein [Function unknown]; Region: COG2261
1036673020121	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673020122	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673020123	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1036673020124	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673020125	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673020126	metal binding site [ion binding]; metal-binding site
1036673020127	active site
1036673020128	I-site; other site
1036673020129	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673020130	RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980
1036673020131	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673020132	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1036673020133	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673020134	DNA binding residues [nucleotide binding]
1036673020135	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1036673020136	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1036673020137	ATP binding site [chemical binding]; other site
1036673020138	G-X-G motif; other site
1036673020139	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1036673020140	anti sigma factor interaction site; other site
1036673020141	regulatory phosphorylation site [posttranslational modification]; other site
1036673020142	Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103
1036673020143	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1036673020144	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1036673020145	dimerization interface [polypeptide binding]; other site
1036673020146	DPS ferroxidase diiron center [ion binding]; other site
1036673020147	ion pore; other site
1036673020148	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1036673020149	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1036673020150	ligand binding site [chemical binding]; other site
1036673020151	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1036673020152	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1036673020153	Walker A/P-loop; other site
1036673020154	ATP binding site [chemical binding]; other site
1036673020155	Q-loop/lid; other site
1036673020156	ABC transporter signature motif; other site
1036673020157	Walker B; other site
1036673020158	D-loop; other site
1036673020159	H-loop/switch region; other site
1036673020160	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1036673020161	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1036673020162	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1036673020163	TM-ABC transporter signature motif; other site
1036673020164	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1036673020165	TM-ABC transporter signature motif; other site
1036673020166	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1036673020167	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1036673020168	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1036673020169	anti sigma factor interaction site; other site
1036673020170	regulatory phosphorylation site [posttranslational modification]; other site
1036673020171	Protein of unknown function (DUF3464); Region: DUF3464; pfam11947
1036673020172	Heat induced stress protein YflT; Region: YflT; pfam11181
1036673020173	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
1036673020174	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1036673020175	ligand binding site; other site
1036673020176	oligomer interface; other site
1036673020177	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1036673020178	N-terminal domain interface [polypeptide binding]; other site
1036673020179	sulfate 1 binding site; other site
1036673020180	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673020181	Interdomain contacts; other site
1036673020182	Cytokine receptor motif; other site
1036673020183	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673020184	Interdomain contacts; other site
1036673020185	Cytokine receptor motif; other site
1036673020186	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673020187	Interdomain contacts; other site
1036673020188	Cytokine receptor motif; other site
1036673020189	Type II cohesin domain, interaction partner of dockerin; Region: Type_II_cohesin; cd08547
1036673020190	dockerin binding interface; other site
1036673020191	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673020192	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673020193	active site
1036673020194	phosphorylation site [posttranslational modification]
1036673020195	intermolecular recognition site; other site
1036673020196	dimerization interface [polypeptide binding]; other site
1036673020197	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673020198	dimer interface [polypeptide binding]; other site
1036673020199	phosphorylation site [posttranslational modification]
1036673020200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673020201	ATP binding site [chemical binding]; other site
1036673020202	Mg2+ binding site [ion binding]; other site
1036673020203	G-X-G motif; other site
1036673020204	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1036673020205	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1036673020206	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1036673020207	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
1036673020208	dimerization interface [polypeptide binding]; other site
1036673020209	GAF domain; Region: GAF_3; pfam13492
1036673020210	GAF domain; Region: GAF_2; pfam13185
1036673020211	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673020212	dimer interface [polypeptide binding]; other site
1036673020213	phosphorylation site [posttranslational modification]
1036673020214	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673020215	ATP binding site [chemical binding]; other site
1036673020216	Mg2+ binding site [ion binding]; other site
1036673020217	G-X-G motif; other site
1036673020218	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673020219	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673020220	active site
1036673020221	phosphorylation site [posttranslational modification]
1036673020222	intermolecular recognition site; other site
1036673020223	dimerization interface [polypeptide binding]; other site
1036673020224	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673020225	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673020226	active site
1036673020227	phosphorylation site [posttranslational modification]
1036673020228	intermolecular recognition site; other site
1036673020229	dimerization interface [polypeptide binding]; other site
1036673020230	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673020231	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673020232	active site
1036673020233	phosphorylation site [posttranslational modification]
1036673020234	intermolecular recognition site; other site
1036673020235	dimerization interface [polypeptide binding]; other site
1036673020236	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673020237	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673020238	active site
1036673020239	phosphorylation site [posttranslational modification]
1036673020240	intermolecular recognition site; other site
1036673020241	dimerization interface [polypeptide binding]; other site
1036673020242	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1036673020243	Heat induced stress protein YflT; Region: YflT; pfam11181
1036673020244	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1036673020245	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1036673020246	NodB motif; other site
1036673020247	active site
1036673020248	catalytic site [active]
1036673020249	metal binding site [ion binding]; metal-binding site
1036673020250	RNA polymerase factor sigma C; Reviewed; Region: PRK09415
1036673020251	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673020252	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673020253	DNA binding residues [nucleotide binding]
1036673020254	Protein of unknown function (DUF3048); Region: DUF3048; pfam11258
1036673020255	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1036673020256	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1036673020257	The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363
1036673020258	Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900
1036673020259	putative active site [active]
1036673020260	metal binding site [ion binding]; metal-binding site
1036673020261	DinB superfamily; Region: DinB_2; pfam12867
1036673020262	Predicted transcriptional regulator [Transcription]; Region: COG2378
1036673020263	HTH domain; Region: HTH_11; pfam08279
1036673020264	WYL domain; Region: WYL; pfam13280
1036673020265	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1036673020266	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1036673020267	catalytic residues [active]
1036673020268	IDEAL domain; Region: IDEAL; cl07452
1036673020269	Predicted transcriptional regulator [Transcription]; Region: COG1959
1036673020270	Transcriptional regulator; Region: Rrf2; pfam02082
1036673020271	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
1036673020272	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
1036673020273	siderophore binding site; other site
1036673020274	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1036673020275	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673020276	ABC-ATPase subunit  interface; other site
1036673020277	dimer interface [polypeptide binding]; other site
1036673020278	putative PBP binding regions; other site
1036673020279	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1036673020280	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673020281	ABC-ATPase subunit  interface; other site
1036673020282	dimer interface [polypeptide binding]; other site
1036673020283	putative PBP binding regions; other site
1036673020284	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1036673020285	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1036673020286	Walker A/P-loop; other site
1036673020287	ATP binding site [chemical binding]; other site
1036673020288	Q-loop/lid; other site
1036673020289	ABC transporter signature motif; other site
1036673020290	Walker B; other site
1036673020291	D-loop; other site
1036673020292	H-loop/switch region; other site
1036673020293	This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784
1036673020294	glycosyltransferase, MGT family; Region: MGT; TIGR01426
1036673020295	active site
1036673020296	TDP-binding site; other site
1036673020297	acceptor substrate-binding pocket; other site
1036673020298	homodimer interface [polypeptide binding]; other site
1036673020299	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1036673020300	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1036673020301	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1036673020302	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1036673020303	IMP cyclohydrolase-like protein; Region: IMP_cyclohyd; cl01330
1036673020304	5-aminoimidazole-4-carboxamide ribonucleotide transformylase; Provisional; Region: PRK07106
1036673020305	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1036673020306	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1036673020307	active site
1036673020308	substrate binding site [chemical binding]; other site
1036673020309	cosubstrate binding site; other site
1036673020310	catalytic site [active]
1036673020311	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1036673020312	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1036673020313	dimerization interface [polypeptide binding]; other site
1036673020314	putative ATP binding site [chemical binding]; other site
1036673020315	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
1036673020316	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1036673020317	active site
1036673020318	tetramer interface [polypeptide binding]; other site
1036673020319	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036673020320	active site
1036673020321	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1036673020322	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1036673020323	dimerization interface [polypeptide binding]; other site
1036673020324	ATP binding site [chemical binding]; other site
1036673020325	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1036673020326	dimerization interface [polypeptide binding]; other site
1036673020327	ATP binding site [chemical binding]; other site
1036673020328	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1036673020329	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1036673020330	putative active site [active]
1036673020331	catalytic triad [active]
1036673020332	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
1036673020333	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
1036673020334	ATP binding site [chemical binding]; other site
1036673020335	active site
1036673020336	substrate binding site [chemical binding]; other site
1036673020337	adenylosuccinate lyase; Provisional; Region: PRK07492
1036673020338	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1036673020339	tetramer interface [polypeptide binding]; other site
1036673020340	active site
1036673020341	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1036673020342	ATP-grasp domain; Region: ATP-grasp; pfam02222
1036673020343	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1036673020344	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673020345	3D domain; Region: 3D; cl01439
1036673020346	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1036673020347	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
1036673020348	NodB motif; other site
1036673020349	active site
1036673020350	catalytic site [active]
1036673020351	metal binding site [ion binding]; metal-binding site
1036673020352	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
1036673020353	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
1036673020354	UGMP family protein; Validated; Region: PRK09604
1036673020355	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1036673020356	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1036673020357	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673020358	Coenzyme A binding pocket [chemical binding]; other site
1036673020359	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1036673020360	Glycoprotease family; Region: Peptidase_M22; pfam00814
1036673020361	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1036673020362	thiamine monophosphate kinase; Provisional; Region: PRK05731
1036673020363	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
1036673020364	ATP binding site [chemical binding]; other site
1036673020365	dimerization interface [polypeptide binding]; other site
1036673020366	Small acid-soluble spore protein H family; Region: SspH; cl06949
1036673020367	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
1036673020368	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
1036673020369	putative DNA binding site [nucleotide binding]; other site
1036673020370	putative homodimer interface [polypeptide binding]; other site
1036673020371	metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459
1036673020372	TrkA-C domain; Region: TrkA_C; pfam02080
1036673020373	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
1036673020374	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
1036673020375	active site
1036673020376	DNA binding site [nucleotide binding]
1036673020377	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
1036673020378	DNA binding site [nucleotide binding]
1036673020379	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
1036673020380	nucleotide binding site [chemical binding]; other site
1036673020381	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1036673020382	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1036673020383	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1036673020384	putative active site [active]
1036673020385	catalytic site [active]
1036673020386	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1036673020387	putative active site [active]
1036673020388	catalytic site [active]
1036673020389	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
1036673020390	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
1036673020391	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
1036673020392	Spore germination protein; Region: Spore_permease; cl17796
1036673020393	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1036673020394	Peptidase family M23; Region: Peptidase_M23; pfam01551
1036673020395	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1036673020396	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
1036673020397	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1036673020398	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673020399	motif II; other site
1036673020400	aminoglycoside resistance protein; Provisional; Region: PRK13746
1036673020401	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
1036673020402	metal binding triad [ion binding]; metal-binding site
1036673020403	Domain of unknown function (DUF4111); Region: DUF4111; pfam13427
1036673020404	Domain of unknown function (DUF4173); Region: DUF4173; pfam13777
1036673020405	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
1036673020406	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
1036673020407	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1036673020408	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
1036673020409	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036673020410	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1036673020411	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1036673020412	active site
1036673020413	dimer interface [polypeptide binding]; other site
1036673020414	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1036673020415	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1036673020416	active site
1036673020417	FMN binding site [chemical binding]; other site
1036673020418	substrate binding site [chemical binding]; other site
1036673020419	3Fe-4S cluster binding site [ion binding]; other site
1036673020420	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1036673020421	domain interface; other site
1036673020422	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673020423	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1036673020424	putative active site [active]
1036673020425	heme pocket [chemical binding]; other site
1036673020426	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673020427	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1036673020428	putative active site [active]
1036673020429	heme pocket [chemical binding]; other site
1036673020430	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673020431	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1036673020432	putative active site [active]
1036673020433	heme pocket [chemical binding]; other site
1036673020434	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673020435	phosphorylation site [posttranslational modification]
1036673020436	dimer interface [polypeptide binding]; other site
1036673020437	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673020438	ATP binding site [chemical binding]; other site
1036673020439	Mg2+ binding site [ion binding]; other site
1036673020440	G-X-G motif; other site
1036673020441	thymidine kinase; Provisional; Region: PRK04296
1036673020442	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
1036673020443	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673020444	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673020445	homodimer interface [polypeptide binding]; other site
1036673020446	catalytic residue [active]
1036673020447	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1036673020448	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1036673020449	DNA-binding site [nucleotide binding]; DNA binding site
1036673020450	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1036673020451	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673020452	homodimer interface [polypeptide binding]; other site
1036673020453	catalytic residue [active]
1036673020454	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
1036673020455	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673020456	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673020457	DNA binding residues [nucleotide binding]
1036673020458	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1036673020459	Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408
1036673020460	putative active site [active]
1036673020461	putative metal binding site [ion binding]; other site
1036673020462	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1036673020463	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673020464	Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152
1036673020465	putative homodimer interface [polypeptide binding]; other site
1036673020466	putative homotetramer interface [polypeptide binding]; other site
1036673020467	allosteric switch controlling residues; other site
1036673020468	putative metal binding site [ion binding]; other site
1036673020469	putative homodimer-homodimer interface [polypeptide binding]; other site
1036673020470	Uncharacterized conserved protein [Function unknown]; Region: COG3349
1036673020471	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036673020472	intracellular protease, PfpI family; Region: PfpI; TIGR01382
1036673020473	A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134
1036673020474	proposed catalytic triad [active]
1036673020475	conserved cys residue [active]
1036673020476	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1036673020477	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1036673020478	Ca binding site [ion binding]; other site
1036673020479	active site
1036673020480	catalytic site [active]
1036673020481	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1036673020482	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1036673020483	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
1036673020484	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673020485	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673020486	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
1036673020487	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
1036673020488	putative ADP-ribose binding site [chemical binding]; other site
1036673020489	putative active site [active]
1036673020490	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673020491	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673020492	active site
1036673020493	phosphorylation site [posttranslational modification]
1036673020494	intermolecular recognition site; other site
1036673020495	dimerization interface [polypeptide binding]; other site
1036673020496	Coat F domain; Region: Coat_F; pfam07875
1036673020497	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673020498	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673020499	SmpA / OmlA family; Region: SmpA_OmlA; cl17115
1036673020500	CheW-like domain; Region: CheW; pfam01584
1036673020501	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1036673020502	lipoyl attachment site [posttranslational modification]; other site
1036673020503	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
1036673020504	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1036673020505	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
1036673020506	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1036673020507	tetramer interface [polypeptide binding]; other site
1036673020508	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673020509	catalytic residue [active]
1036673020510	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1036673020511	tetramer interface [polypeptide binding]; other site
1036673020512	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673020513	catalytic residue [active]
1036673020514	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
1036673020515	Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; cl01811
1036673020516	siderophore-iron reductase FhuF; Region: Fe_III_red_FhuF; TIGR03951
1036673020517	FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575
1036673020518	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
1036673020519	Lamin Tail Domain; Region: LTD; pfam00932
1036673020520	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
1036673020521	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673020522	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673020523	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673020524	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1036673020525	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1036673020526	DNA binding site [nucleotide binding]
1036673020527	domain linker motif; other site
1036673020528	Ligand-binding domain of a novel transcription factor implicated in catabolite repression in Bacillus and Clostridium species; Region: PBP1_CcpB_like; cd06286
1036673020529	putative dimerization interface [polypeptide binding]; other site
1036673020530	putative ligand binding site [chemical binding]; other site
1036673020531	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673020532	Interdomain contacts; other site
1036673020533	Cytokine receptor motif; other site
1036673020534	Domains similar to the eukaryotic reeler domain and bacterial cohesins; Region: Reeler_cohesin_like; cl14606
1036673020535	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1036673020536	Glyco_18 domain; Region: Glyco_18; smart00636
1036673020537	active site
1036673020538	S-layer homology domain; Region: SLH; pfam00395
1036673020539	S-layer homology domain; Region: SLH; pfam00395
1036673020540	S-layer homology domain; Region: SLH; pfam00395
1036673020541	phytoene desaturase; Region: phytoene_desat; TIGR02731
1036673020542	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1036673020543	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1036673020544	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1036673020545	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1036673020546	Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831
1036673020547	oligomer interface [polypeptide binding]; other site
1036673020548	metal binding site [ion binding]; metal-binding site
1036673020549	metal binding site [ion binding]; metal-binding site
1036673020550	putative Cl binding site [ion binding]; other site
1036673020551	aspartate ring; other site
1036673020552	basic sphincter; other site
1036673020553	hydrophobic gate; other site
1036673020554	periplasmic entrance; other site
1036673020555	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1036673020556	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1036673020557	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673020558	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673020559	Predicted membrane protein [Function unknown]; Region: COG3326
1036673020560	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1036673020561	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673020562	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673020563	metal binding site [ion binding]; metal-binding site
1036673020564	active site
1036673020565	I-site; other site
1036673020566	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673020567	dimer interface [polypeptide binding]; other site
1036673020568	phosphorylation site [posttranslational modification]
1036673020569	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673020570	ATP binding site [chemical binding]; other site
1036673020571	Mg2+ binding site [ion binding]; other site
1036673020572	G-X-G motif; other site
1036673020573	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673020574	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673020575	active site
1036673020576	phosphorylation site [posttranslational modification]
1036673020577	intermolecular recognition site; other site
1036673020578	dimerization interface [polypeptide binding]; other site
1036673020579	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673020580	DNA binding site [nucleotide binding]
1036673020581	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1036673020582	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673020583	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673020584	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673020585	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673020586	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1036673020587	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673020588	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673020589	dimer interface [polypeptide binding]; other site
1036673020590	conserved gate region; other site
1036673020591	putative PBP binding loops; other site
1036673020592	ABC-ATPase subunit interface; other site
1036673020593	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673020594	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673020595	dimer interface [polypeptide binding]; other site
1036673020596	conserved gate region; other site
1036673020597	ABC-ATPase subunit interface; other site
1036673020598	Glycosyl hydrolase family 43; Region: GH43_6; cd08985
1036673020599	active site
1036673020600	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1036673020601	sugar binding site [chemical binding]; other site
1036673020602	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1036673020603	Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149
1036673020604	NAD(P) binding site [chemical binding]; other site
1036673020605	catalytic residues [active]
1036673020606	4-aminobutyrate aminotransferase; Reviewed; Region: PRK06918
1036673020607	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036673020608	inhibitor-cofactor binding pocket; inhibition site
1036673020609	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673020610	catalytic residue [active]
1036673020611	putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522
1036673020612	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1036673020613	inhibitor-cofactor binding pocket; inhibition site
1036673020614	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673020615	catalytic residue [active]
1036673020616	Bacillus subtilis NAD+-dependent betaine aldehyde dehydrogenase-like; Region: ALDH_BADH-GbsA; cd07119
1036673020617	glycine betaine aldehyde dehydrogenase; Region: BADH; TIGR01804
1036673020618	tetramerization interface [polypeptide binding]; other site
1036673020619	NAD(P) binding site [chemical binding]; other site
1036673020620	catalytic residues [active]
1036673020621	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1036673020622	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1036673020623	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1036673020624	NAD(P) binding site [chemical binding]; other site
1036673020625	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
1036673020626	tetramer interface [polypeptide binding]; other site
1036673020627	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
1036673020628	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
1036673020629	active site
1036673020630	multimer interface [polypeptide binding]; other site
1036673020631	Protein of unknown function (DUF441); Region: DUF441; pfam04284
1036673020632	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673020633	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673020634	ATP binding site [chemical binding]; other site
1036673020635	Mg2+ binding site [ion binding]; other site
1036673020636	G-X-G motif; other site
1036673020637	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673020638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673020639	active site
1036673020640	phosphorylation site [posttranslational modification]
1036673020641	intermolecular recognition site; other site
1036673020642	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1036673020643	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1036673020644	carboxyltransferase (CT) interaction site; other site
1036673020645	biotinylation site [posttranslational modification]; other site
1036673020646	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
1036673020647	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
1036673020648	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673020649	putative active site [active]
1036673020650	heme pocket [chemical binding]; other site
1036673020651	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673020652	Walker A motif; other site
1036673020653	ATP binding site [chemical binding]; other site
1036673020654	Walker B motif; other site
1036673020655	arginine finger; other site
1036673020656	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1036673020657	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1036673020658	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1036673020659	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1036673020660	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1036673020661	agmatinase; Region: agmatinase; TIGR01230
1036673020662	oligomer interface [polypeptide binding]; other site
1036673020663	putative active site [active]
1036673020664	Mn binding site [ion binding]; other site
1036673020665	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1036673020666	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1036673020667	HIGH motif; other site
1036673020668	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1036673020669	active site
1036673020670	KMSKS motif; other site
1036673020671	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1036673020672	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673020673	ATP binding site [chemical binding]; other site
1036673020674	Mg2+ binding site [ion binding]; other site
1036673020675	G-X-G motif; other site
1036673020676	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1036673020677	Amidinotransferase; Region: Amidinotransf; pfam02274
1036673020678	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1036673020679	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1036673020680	active site
1036673020681	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
1036673020682	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1036673020683	catalytic core [active]
1036673020684	EamA-like transporter family; Region: EamA; pfam00892
1036673020685	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1036673020686	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1036673020687	glutaminase active site [active]
1036673020688	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1036673020689	dimer interface [polypeptide binding]; other site
1036673020690	active site
1036673020691	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1036673020692	dimer interface [polypeptide binding]; other site
1036673020693	active site
1036673020694	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1036673020695	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1036673020696	active site
1036673020697	substrate binding site [chemical binding]; other site
1036673020698	metal binding site [ion binding]; metal-binding site
1036673020699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1036673020700	YbbR-like protein; Region: YbbR; pfam07949
1036673020701	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1036673020702	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1036673020703	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1036673020704	Putative zinc-finger; Region: zf-HC2; pfam13490
1036673020705	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1036673020706	RNA polymerase sigma factor SigW; Provisional; Region: PRK09641
1036673020707	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673020708	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1036673020709	DNA binding residues [nucleotide binding]
1036673020710	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1036673020711	Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311
1036673020712	CHASE3 domain; Region: CHASE3; pfam05227
1036673020713	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673020714	dimerization interface [polypeptide binding]; other site
1036673020715	GAF domain; Region: GAF_2; pfam13185
1036673020716	GAF domain; Region: GAF; pfam01590
1036673020717	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673020718	dimer interface [polypeptide binding]; other site
1036673020719	phosphorylation site [posttranslational modification]
1036673020720	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673020721	ATP binding site [chemical binding]; other site
1036673020722	Mg2+ binding site [ion binding]; other site
1036673020723	G-X-G motif; other site
1036673020724	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673020725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673020726	active site
1036673020727	phosphorylation site [posttranslational modification]
1036673020728	intermolecular recognition site; other site
1036673020729	dimerization interface [polypeptide binding]; other site
1036673020730	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1036673020731	homodimer interface [polypeptide binding]; other site
1036673020732	maltodextrin glucosidase; Provisional; Region: PRK10785
1036673020733	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1036673020734	active site
1036673020735	homodimer interface [polypeptide binding]; other site
1036673020736	catalytic site [active]
1036673020737	Heat induced stress protein YflT; Region: YflT; pfam11181
1036673020738	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1036673020739	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1036673020740	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1036673020741	classical (c) SDRs; Region: SDR_c; cd05233
1036673020742	NAD(P) binding site [chemical binding]; other site
1036673020743	active site
1036673020744	Integral membrane protein DUF95; Region: DUF95; pfam01944
1036673020745	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1036673020746	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1036673020747	KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089
1036673020748	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
1036673020749	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1036673020750	Walker A motif; other site
1036673020751	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1036673020752	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1036673020753	active site
1036673020754	metal binding site [ion binding]; metal-binding site
1036673020755	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
1036673020756	ATP-sulfurylase; Region: ATPS; cd00517
1036673020757	active site
1036673020758	HXXH motif; other site
1036673020759	flexible loop; other site
1036673020760	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1036673020761	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1036673020762	Active Sites [active]
1036673020763	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1036673020764	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1036673020765	23S rRNA interface [nucleotide binding]; other site
1036673020766	L3 interface [polypeptide binding]; other site
1036673020767	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1036673020768	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1036673020769	dimerization interface 3.5A [polypeptide binding]; other site
1036673020770	active site
1036673020771	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1036673020772	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1036673020773	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1036673020774	alphaNTD - beta interaction site [polypeptide binding]; other site
1036673020775	alphaNTD homodimer interface [polypeptide binding]; other site
1036673020776	alphaNTD - beta' interaction site [polypeptide binding]; other site
1036673020777	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1036673020778	30S ribosomal protein S11; Validated; Region: PRK05309
1036673020779	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
1036673020780	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1036673020781	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1036673020782	rRNA binding site [nucleotide binding]; other site
1036673020783	predicted 30S ribosome binding site; other site
1036673020784	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
1036673020785	RNA binding site [nucleotide binding]; other site
1036673020786	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1036673020787	active site
1036673020788	adenylate kinase; Reviewed; Region: adk; PRK00279
1036673020789	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1036673020790	AMP-binding site [chemical binding]; other site
1036673020791	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1036673020792	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1036673020793	SecY translocase; Region: SecY; pfam00344
1036673020794	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1036673020795	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1036673020796	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1036673020797	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1036673020798	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1036673020799	5S rRNA interface [nucleotide binding]; other site
1036673020800	L27 interface [polypeptide binding]; other site
1036673020801	23S rRNA interface [nucleotide binding]; other site
1036673020802	L5 interface [polypeptide binding]; other site
1036673020803	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1036673020804	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1036673020805	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1036673020806	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1036673020807	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1036673020808	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1036673020809	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1036673020810	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1036673020811	RNA binding site [nucleotide binding]; other site
1036673020812	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1036673020813	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1036673020814	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1036673020815	23S rRNA interface [nucleotide binding]; other site
1036673020816	putative translocon interaction site; other site
1036673020817	signal recognition particle (SRP54) interaction site; other site
1036673020818	L23 interface [polypeptide binding]; other site
1036673020819	trigger factor interaction site; other site
1036673020820	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1036673020821	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1036673020822	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1036673020823	G-X-X-G motif; other site
1036673020824	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1036673020825	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1036673020826	putative translocon binding site; other site
1036673020827	protein-rRNA interface [nucleotide binding]; other site
1036673020828	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1036673020829	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1036673020830	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1036673020831	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1036673020832	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1036673020833	Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325
1036673020834	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1036673020835	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1036673020836	elongation factor Tu; Reviewed; Region: PRK00049
1036673020837	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1036673020838	G1 box; other site
1036673020839	GEF interaction site [polypeptide binding]; other site
1036673020840	GTP/Mg2+ binding site [chemical binding]; other site
1036673020841	Switch I region; other site
1036673020842	G2 box; other site
1036673020843	G3 box; other site
1036673020844	Switch II region; other site
1036673020845	G4 box; other site
1036673020846	G5 box; other site
1036673020847	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1036673020848	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1036673020849	Antibiotic Binding Site [chemical binding]; other site
1036673020850	elongation factor G; Reviewed; Region: PRK00007
1036673020851	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1036673020852	G1 box; other site
1036673020853	putative GEF interaction site [polypeptide binding]; other site
1036673020854	GTP/Mg2+ binding site [chemical binding]; other site
1036673020855	Switch I region; other site
1036673020856	G2 box; other site
1036673020857	G3 box; other site
1036673020858	Switch II region; other site
1036673020859	G4 box; other site
1036673020860	G5 box; other site
1036673020861	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1036673020862	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1036673020863	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1036673020864	Ribosomal protein S7p/S5e; Region: Ribosomal_S7; cl00313
1036673020865	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1036673020866	S17 interaction site [polypeptide binding]; other site
1036673020867	S8 interaction site; other site
1036673020868	16S rRNA interaction site [nucleotide binding]; other site
1036673020869	streptomycin interaction site [chemical binding]; other site
1036673020870	23S rRNA interaction site [nucleotide binding]; other site
1036673020871	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1036673020872	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
1036673020873	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1036673020874	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1036673020875	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1036673020876	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1036673020877	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1036673020878	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1036673020879	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1036673020880	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1036673020881	G-loop; other site
1036673020882	DNA binding site [nucleotide binding]
1036673020883	DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085
1036673020884	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1036673020885	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1036673020886	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1036673020887	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1036673020888	RPB10 interaction site [polypeptide binding]; other site
1036673020889	RPB1 interaction site [polypeptide binding]; other site
1036673020890	RPB11 interaction site [polypeptide binding]; other site
1036673020891	RPB3 interaction site [polypeptide binding]; other site
1036673020892	RPB12 interaction site [polypeptide binding]; other site
1036673020893	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036673020894	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673020895	S-adenosylmethionine binding site [chemical binding]; other site
1036673020896	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1036673020897	core dimer interface [polypeptide binding]; other site
1036673020898	peripheral dimer interface [polypeptide binding]; other site
1036673020899	L10 interface [polypeptide binding]; other site
1036673020900	L11 interface [polypeptide binding]; other site
1036673020901	putative EF-Tu interaction site [polypeptide binding]; other site
1036673020902	putative EF-G interaction site [polypeptide binding]; other site
1036673020903	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1036673020904	23S rRNA interface [nucleotide binding]; other site
1036673020905	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1036673020906	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1036673020907	mRNA/rRNA interface [nucleotide binding]; other site
1036673020908	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1036673020909	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1036673020910	23S rRNA interface [nucleotide binding]; other site
1036673020911	L7/L12 interface [polypeptide binding]; other site
1036673020912	putative thiostrepton binding site; other site
1036673020913	L25 interface [polypeptide binding]; other site
1036673020914	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1036673020915	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1036673020916	putative homodimer interface [polypeptide binding]; other site
1036673020917	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1036673020918	heterodimer interface [polypeptide binding]; other site
1036673020919	homodimer interface [polypeptide binding]; other site
1036673020920	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1036673020921	RNA polymerase factor sigma-70; Validated; Region: PRK08295
1036673020922	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1036673020923	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1036673020924	YacP-like NYN domain; Region: NYN_YacP; pfam05991
1036673020925	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1036673020926	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1036673020927	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1036673020928	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
1036673020929	dimerization interface [polypeptide binding]; other site
1036673020930	active site
1036673020931	metal binding site [ion binding]; metal-binding site
1036673020932	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1036673020933	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1036673020934	active site
1036673020935	HIGH motif; other site
1036673020936	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1036673020937	KMSKS motif; other site
1036673020938	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
1036673020939	tRNA binding surface [nucleotide binding]; other site
1036673020940	anticodon binding site; other site
1036673020941	putative acyl transferase; Provisional; Region: PRK10191
1036673020942	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1036673020943	trimer interface [polypeptide binding]; other site
1036673020944	active site
1036673020945	substrate binding site [chemical binding]; other site
1036673020946	CoA binding site [chemical binding]; other site
1036673020947	Regulator of G protein signaling (RGS) domain superfamily; Region: RGS; cl02565
1036673020948	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1036673020949	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1036673020950	active site
1036673020951	HIGH motif; other site
1036673020952	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1036673020953	active site
1036673020954	KMSKS motif; other site
1036673020955	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1036673020956	homotrimer interaction site [polypeptide binding]; other site
1036673020957	zinc binding site [ion binding]; other site
1036673020958	CDP-binding sites; other site
1036673020959	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1036673020960	substrate binding site; other site
1036673020961	dimer interface; other site
1036673020962	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
1036673020963	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
1036673020964	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
1036673020965	putative active site [active]
1036673020966	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1036673020967	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1036673020968	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
1036673020969	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1036673020970	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
1036673020971	DNA repair protein RadA; Provisional; Region: PRK11823
1036673020972	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1036673020973	Walker A motif/ATP binding site; other site
1036673020974	ATP binding site [chemical binding]; other site
1036673020975	Walker B motif; other site
1036673020976	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1036673020977	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1036673020978	Clp amino terminal domain; Region: Clp_N; pfam02861
1036673020979	Clp amino terminal domain; Region: Clp_N; pfam02861
1036673020980	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673020981	Walker A motif; other site
1036673020982	ATP binding site [chemical binding]; other site
1036673020983	Walker B motif; other site
1036673020984	arginine finger; other site
1036673020985	UvrB/uvrC motif; Region: UVR; pfam02151
1036673020986	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673020987	Walker A motif; other site
1036673020988	ATP binding site [chemical binding]; other site
1036673020989	Walker B motif; other site
1036673020990	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1036673020991	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
1036673020992	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
1036673020993	ADP binding site [chemical binding]; other site
1036673020994	phosphagen binding site; other site
1036673020995	substrate specificity loop; other site
1036673020996	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
1036673020997	UvrB/uvrC motif; Region: UVR; pfam02151
1036673020998	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
1036673020999	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1036673021000	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1036673021001	dimer interface [polypeptide binding]; other site
1036673021002	putative anticodon binding site; other site
1036673021003	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1036673021004	motif 1; other site
1036673021005	active site
1036673021006	motif 2; other site
1036673021007	motif 3; other site
1036673021008	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1036673021009	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1036673021010	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1036673021011	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1036673021012	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1036673021013	FMN binding site [chemical binding]; other site
1036673021014	active site
1036673021015	catalytic residues [active]
1036673021016	substrate binding site [chemical binding]; other site
1036673021017	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673021018	non-specific DNA binding site [nucleotide binding]; other site
1036673021019	salt bridge; other site
1036673021020	sequence-specific DNA binding site [nucleotide binding]; other site
1036673021021	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1036673021022	catalytic center binding site [active]
1036673021023	ATP binding site [chemical binding]; other site
1036673021024	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1036673021025	homooctamer interface [polypeptide binding]; other site
1036673021026	active site
1036673021027	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1036673021028	dihydropteroate synthase; Region: DHPS; TIGR01496
1036673021029	substrate binding pocket [chemical binding]; other site
1036673021030	dimer interface [polypeptide binding]; other site
1036673021031	inhibitor binding site; inhibition site
1036673021032	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1036673021033	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
1036673021034	homodimer interface [polypeptide binding]; other site
1036673021035	substrate-cofactor binding pocket; other site
1036673021036	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673021037	catalytic residue [active]
1036673021038	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1036673021039	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1036673021040	glutamine binding [chemical binding]; other site
1036673021041	catalytic triad [active]
1036673021042	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
1036673021043	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1036673021044	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1036673021045	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1036673021046	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1036673021047	dimer interface [polypeptide binding]; other site
1036673021048	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1036673021049	catalytic residue [active]
1036673021050	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
1036673021051	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1036673021052	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1036673021053	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1036673021054	dimerization interface [polypeptide binding]; other site
1036673021055	domain crossover interface; other site
1036673021056	redox-dependent activation switch; other site
1036673021057	pantothenate kinase; Reviewed; Region: PRK13318
1036673021058	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
1036673021059	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1036673021060	dimerization interface [polypeptide binding]; other site
1036673021061	active site
1036673021062	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
1036673021063	L-aspartate oxidase; Provisional; Region: PRK06175
1036673021064	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1036673021065	Quinolinate synthetase A protein; Region: NadA; pfam02445
1036673021066	FtsH Extracellular; Region: FtsH_ext; pfam06480
1036673021067	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1036673021068	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673021069	Walker A motif; other site
1036673021070	ATP binding site [chemical binding]; other site
1036673021071	Walker B motif; other site
1036673021072	arginine finger; other site
1036673021073	Peptidase family M41; Region: Peptidase_M41; pfam01434
1036673021074	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036673021075	active site
1036673021076	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1036673021077	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1036673021078	Ligand Binding Site [chemical binding]; other site
1036673021079	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1036673021080	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
1036673021081	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
1036673021082	active site
1036673021083	ATP binding site [chemical binding]; other site
1036673021084	substrate binding site [chemical binding]; other site
1036673021085	activation loop (A-loop); other site
1036673021086	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
1036673021087	stage II sporulation protein E; Region: spore_II_E; TIGR02865
1036673021088	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1036673021089	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1036673021090	RNA binding site [nucleotide binding]; other site
1036673021091	Septum formation initiator; Region: DivIC; pfam04977
1036673021092	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1036673021093	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801
1036673021094	YabP family; Region: YabP; cl06766
1036673021095	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036673021096	RNA binding surface [nucleotide binding]; other site
1036673021097	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1036673021098	IHF dimer interface [polypeptide binding]; other site
1036673021099	IHF - DNA interface [nucleotide binding]; other site
1036673021100	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
1036673021101	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
1036673021102	putative SAM binding site [chemical binding]; other site
1036673021103	putative homodimer interface [polypeptide binding]; other site
1036673021104	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1036673021105	homodimer interface [polypeptide binding]; other site
1036673021106	metal binding site [ion binding]; metal-binding site
1036673021107	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1036673021108	homodimer interface [polypeptide binding]; other site
1036673021109	active site
1036673021110	putative chemical substrate binding site [chemical binding]; other site
1036673021111	metal binding site [ion binding]; metal-binding site
1036673021112	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
1036673021113	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1036673021114	GAF domain; Region: GAF; cl17456
1036673021115	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
1036673021116	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1036673021117	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1036673021118	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1036673021119	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673021120	ATP binding site [chemical binding]; other site
1036673021121	putative Mg++ binding site [ion binding]; other site
1036673021122	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673021123	nucleotide binding region [chemical binding]; other site
1036673021124	ATP-binding site [chemical binding]; other site
1036673021125	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1036673021126	Protein of unknown function (DUF2757); Region: DUF2757; pfam10955
1036673021127	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1036673021128	putative active site [active]
1036673021129	catalytic residue [active]
1036673021130	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1036673021131	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1036673021132	5S rRNA interface [nucleotide binding]; other site
1036673021133	CTC domain interface [polypeptide binding]; other site
1036673021134	L16 interface [polypeptide binding]; other site
1036673021135	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1036673021136	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1036673021137	Substrate binding site; other site
1036673021138	Mg++ binding site; other site
1036673021139	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1036673021140	active site
1036673021141	substrate binding site [chemical binding]; other site
1036673021142	CoA binding site [chemical binding]; other site
1036673021143	SpoVG; Region: SpoVG; cl00915
1036673021144	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1036673021145	homotrimer interaction site [polypeptide binding]; other site
1036673021146	putative active site [active]
1036673021147	pur operon repressor; Provisional; Region: PRK09213
1036673021148	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1036673021149	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036673021150	active site
1036673021151	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
1036673021152	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1036673021153	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1036673021154	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
1036673021155	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
1036673021156	YabG peptidase U57; Region: Peptidase_U57; cl05250
1036673021157	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1036673021158	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673021159	S-adenosylmethionine binding site [chemical binding]; other site
1036673021160	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
1036673021161	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1036673021162	putative active site [active]
1036673021163	putative metal binding site [ion binding]; other site
1036673021164	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1036673021165	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1036673021166	Domain of unknown function (DUF348); Region: DUF348; pfam03990
1036673021167	G5 domain; Region: G5; pfam07501
1036673021168	3D domain; Region: 3D; cl01439
1036673021169	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1036673021170	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1036673021171	active site
1036673021172	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1036673021173	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1036673021174	Zn2+ binding site [ion binding]; other site
1036673021175	Mg2+ binding site [ion binding]; other site
1036673021176	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
1036673021177	Predicted methyltransferases [General function prediction only]; Region: COG0313
1036673021178	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1036673021179	putative SAM binding site [chemical binding]; other site
1036673021180	putative homodimer interface [polypeptide binding]; other site
1036673021181	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1036673021182	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673021183	S-adenosylmethionine binding site [chemical binding]; other site
1036673021184	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
1036673021185	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
1036673021186	DNA polymerase III subunit delta'; Validated; Region: PRK08058
1036673021187	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1036673021188	Protein of unknown function (DUF327); Region: DUF327; pfam03885
1036673021189	Protein of unknown function (DUF970); Region: DUF970; pfam06153
1036673021190	thymidylate kinase; Validated; Region: tmk; PRK00698
1036673021191	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1036673021192	TMP-binding site; other site
1036673021193	ATP-binding site [chemical binding]; other site
1036673021194	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
1036673021195	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1036673021196	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036673021197	catalytic residue [active]
1036673021198	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
1036673021199	SigmaK-factor processing regulatory protein BofA; Region: BofA; cl06466
1036673021200	recombination protein RecR; Reviewed; Region: recR; PRK00076
1036673021201	RecR protein; Region: RecR; pfam02132
1036673021202	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1036673021203	putative active site [active]
1036673021204	putative metal-binding site [ion binding]; other site
1036673021205	tetramer interface [polypeptide binding]; other site
1036673021206	hypothetical protein; Validated; Region: PRK00153
1036673021207	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1036673021208	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673021209	Walker A motif; other site
1036673021210	ATP binding site [chemical binding]; other site
1036673021211	Walker B motif; other site
1036673021212	arginine finger; other site
1036673021213	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1036673021214	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1036673021215	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1036673021216	putative active site [active]
1036673021217	heme pocket [chemical binding]; other site
1036673021218	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673021219	dimer interface [polypeptide binding]; other site
1036673021220	phosphorylation site [posttranslational modification]
1036673021221	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673021222	ATP binding site [chemical binding]; other site
1036673021223	Mg2+ binding site [ion binding]; other site
1036673021224	G-X-G motif; other site
1036673021225	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673021226	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1036673021227	FeS/SAM binding site; other site
1036673021228	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1036673021229	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1036673021230	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1036673021231	RNA binding site [nucleotide binding]; other site
1036673021232	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1036673021233	multimer interface [polypeptide binding]; other site
1036673021234	Walker A motif; other site
1036673021235	ATP binding site [chemical binding]; other site
1036673021236	Walker B motif; other site
1036673021237	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1036673021238	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1036673021239	hinge; other site
1036673021240	active site
1036673021241	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1036673021242	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1036673021243	intersubunit interface [polypeptide binding]; other site
1036673021244	active site
1036673021245	zinc binding site [ion binding]; other site
1036673021246	Na+ binding site [ion binding]; other site
1036673021247	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673021248	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673021249	active site
1036673021250	phosphorylation site [posttranslational modification]
1036673021251	intermolecular recognition site; other site
1036673021252	dimerization interface [polypeptide binding]; other site
1036673021253	CTP synthetase; Validated; Region: pyrG; PRK05380
1036673021254	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1036673021255	Catalytic site [active]
1036673021256	active site
1036673021257	UTP binding site [chemical binding]; other site
1036673021258	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1036673021259	active site
1036673021260	putative oxyanion hole; other site
1036673021261	catalytic triad [active]
1036673021262	DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363
1036673021263	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1036673021264	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
1036673021265	active site
1036673021266	catalytic residues [active]
1036673021267	Domain of unknown function (DUF1934); Region: DUF1934; cl01870
1036673021268	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673021269	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1036673021270	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673021271	Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385
1036673021272	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1036673021273	putative active site [active]
1036673021274	putative metal binding site [ion binding]; other site
1036673021275	Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997
1036673021276	agmatinase; Region: agmatinase; TIGR01230
1036673021277	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
1036673021278	putative active site [active]
1036673021279	Mn binding site [ion binding]; other site
1036673021280	spermidine synthase; Provisional; Region: PRK00811
1036673021281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673021282	Transglycosylase; Region: Transgly; pfam00912
1036673021283	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1036673021284	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1036673021285	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
1036673021286	PBP superfamily domain; Region: PBP_like_2; cl17296
1036673021287	YwhD family; Region: YwhD; pfam08741
1036673021288	Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604
1036673021289	Zn binding site [ion binding]; other site
1036673021290	NlpC/P60 family; Region: NLPC_P60; pfam00877
1036673021291	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1036673021292	DNA photolyase; Region: DNA_photolyase; pfam00875
1036673021293	PspC domain; Region: PspC; pfam04024
1036673021294	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1036673021295	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
1036673021296	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1036673021297	active site residue [active]
1036673021298	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1036673021299	active site residue [active]
1036673021300	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1036673021301	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1036673021302	phosphoribosyl-dephospho-CoA transferase; Provisional; Region: PRK01293; cl07913
1036673021303	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488
1036673021304	aromatic arch; other site
1036673021305	DCoH dimer interaction site [polypeptide binding]; other site
1036673021306	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1036673021307	DCoH tetramer interaction site [polypeptide binding]; other site
1036673021308	substrate binding site [chemical binding]; other site
1036673021309	SNF2 Helicase protein; Region: DUF3670; pfam12419
1036673021310	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1036673021311	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1036673021312	ATP binding site [chemical binding]; other site
1036673021313	putative Mg++ binding site [ion binding]; other site
1036673021314	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673021315	nucleotide binding region [chemical binding]; other site
1036673021316	ATP-binding site [chemical binding]; other site
1036673021317	CHASE3 domain; Region: CHASE3; pfam05227
1036673021318	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1036673021319	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673021320	dimer interface [polypeptide binding]; other site
1036673021321	phosphorylation site [posttranslational modification]
1036673021322	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673021323	ATP binding site [chemical binding]; other site
1036673021324	Mg2+ binding site [ion binding]; other site
1036673021325	G-X-G motif; other site
1036673021326	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1036673021327	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673021328	active site
1036673021329	phosphorylation site [posttranslational modification]
1036673021330	intermolecular recognition site; other site
1036673021331	dimerization interface [polypeptide binding]; other site
1036673021332	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1036673021333	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
1036673021334	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1036673021335	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
1036673021336	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
1036673021337	Uncharacterized conserved protein [Function unknown]; Region: COG2308
1036673021338	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
1036673021339	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
1036673021340	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
1036673021341	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
1036673021342	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1036673021343	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1036673021344	NAD binding site [chemical binding]; other site
1036673021345	homodimer interface [polypeptide binding]; other site
1036673021346	active site
1036673021347	substrate binding site [chemical binding]; other site
1036673021348	galactokinase; Provisional; Region: PRK05322
1036673021349	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1036673021350	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1036673021351	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1036673021352	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673021353	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673021354	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673021355	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673021356	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
1036673021357	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673021358	dimer interface [polypeptide binding]; other site
1036673021359	phosphorylation site [posttranslational modification]
1036673021360	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673021361	ATP binding site [chemical binding]; other site
1036673021362	Mg2+ binding site [ion binding]; other site
1036673021363	G-X-G motif; other site
1036673021364	Response regulator receiver domain; Region: Response_reg; pfam00072
1036673021365	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673021366	active site
1036673021367	phosphorylation site [posttranslational modification]
1036673021368	intermolecular recognition site; other site
1036673021369	dimerization interface [polypeptide binding]; other site
1036673021370	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673021371	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1036673021372	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1036673021373	RNA binding surface [nucleotide binding]; other site
1036673021374	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
1036673021375	probable active site [active]
1036673021376	Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967
1036673021377	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1036673021378	NAD(P) binding site [chemical binding]; other site
1036673021379	active site
1036673021380	Transglycosylase; Region: Transgly; pfam00912
1036673021381	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1036673021382	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1036673021383	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673021384	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673021385	putative substrate translocation pore; other site
1036673021386	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1036673021387	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673021388	putative substrate translocation pore; other site
1036673021389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673021390	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1036673021391	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673021392	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1036673021393	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673021394	motif II; other site
1036673021395	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1036673021396	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
1036673021397	putative FMN binding site [chemical binding]; other site
1036673021398	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
1036673021399	putative active site [active]
1036673021400	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
1036673021401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673021402	putative substrate translocation pore; other site
1036673021403	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1036673021404	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036673021405	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
1036673021406	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1036673021407	E3 interaction surface; other site
1036673021408	lipoyl attachment site [posttranslational modification]; other site
1036673021409	HlyD family secretion protein; Region: HlyD_3; pfam13437
1036673021410	MarR family; Region: MarR; pfam01047
1036673021411	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673021412	MarR family; Region: MarR_2; pfam12802
1036673021413	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1036673021414	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673021415	S-adenosylmethionine binding site [chemical binding]; other site
1036673021416	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1036673021417	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1036673021418	xanthine permease; Region: pbuX; TIGR03173
1036673021419	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673021420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673021421	dimer interface [polypeptide binding]; other site
1036673021422	conserved gate region; other site
1036673021423	putative PBP binding loops; other site
1036673021424	ABC-ATPase subunit interface; other site
1036673021425	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673021426	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673021427	putative PBP binding loops; other site
1036673021428	dimer interface [polypeptide binding]; other site
1036673021429	ABC-ATPase subunit interface; other site
1036673021430	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673021431	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673021432	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673021433	active site
1036673021434	phosphorylation site [posttranslational modification]
1036673021435	intermolecular recognition site; other site
1036673021436	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673021437	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673021438	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673021439	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673021440	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673021441	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673021442	dimerization interface [polypeptide binding]; other site
1036673021443	Histidine kinase; Region: His_kinase; pfam06580
1036673021444	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673021445	ATP binding site [chemical binding]; other site
1036673021446	Mg2+ binding site [ion binding]; other site
1036673021447	G-X-G motif; other site
1036673021448	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1036673021449	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1036673021450	dimerization interface [polypeptide binding]; other site
1036673021451	DPS ferroxidase diiron center [ion binding]; other site
1036673021452	ion pore; other site
1036673021453	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
1036673021454	SpoOM protein; Region: Spo0M; pfam07070
1036673021455	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1036673021456	active site
1036673021457	substrate binding site [chemical binding]; other site
1036673021458	ATP binding site [chemical binding]; other site
1036673021459	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1036673021460	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1036673021461	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
1036673021462	putative active site [active]
1036673021463	catalytic site [active]
1036673021464	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
1036673021465	putative active site [active]
1036673021466	catalytic site [active]
1036673021467	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1036673021468	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1036673021469	Amidohydrolase; Region: Amidohydro_4; pfam13147
1036673021470	active site
1036673021471	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1036673021472	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1036673021473	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1036673021474	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673021475	putative DNA binding site [nucleotide binding]; other site
1036673021476	putative Zn2+ binding site [ion binding]; other site
1036673021477	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1036673021478	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
1036673021479	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1036673021480	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1036673021481	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673021482	non-specific DNA binding site [nucleotide binding]; other site
1036673021483	salt bridge; other site
1036673021484	sequence-specific DNA binding site [nucleotide binding]; other site
1036673021485	Cupin domain; Region: Cupin_2; pfam07883
1036673021486	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1036673021487	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673021488	S-adenosylmethionine binding site [chemical binding]; other site
1036673021489	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
1036673021490	flavin-dependent oxidoreductase, MSMEG_0569 family; Region: MSMEG_0569_nitr; TIGR04046
1036673021491	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1036673021492	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
1036673021493	apolar tunnel; other site
1036673021494	heme binding site [chemical binding]; other site
1036673021495	dimerization interface [polypeptide binding]; other site
1036673021496	Uncharacterized conserved protein [Function unknown]; Region: COG1801
1036673021497	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1036673021498	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1036673021499	dimer interface [polypeptide binding]; other site
1036673021500	motif 1; other site
1036673021501	active site
1036673021502	motif 2; other site
1036673021503	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1036673021504	putative deacylase active site [active]
1036673021505	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1036673021506	active site
1036673021507	motif 3; other site
1036673021508	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1036673021509	anticodon binding site; other site
1036673021510	MNLL subunit; Region: NADH_oxidored; pfam08040
1036673021511	EcsC protein family; Region: EcsC; pfam12787
1036673021512	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320
1036673021513	Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009
1036673021514	major capsid L1 protein; Provisional; Region: PHA02778
1036673021515	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
1036673021516	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1036673021517	active site
1036673021518	HIGH motif; other site
1036673021519	nucleotide binding site [chemical binding]; other site
1036673021520	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
1036673021521	KMSKS motif; other site
1036673021522	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
1036673021523	GTPase RsgA; Reviewed; Region: PRK01889
1036673021524	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1036673021525	RNA binding site [nucleotide binding]; other site
1036673021526	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1036673021527	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1036673021528	GTP/Mg2+ binding site [chemical binding]; other site
1036673021529	G4 box; other site
1036673021530	G5 box; other site
1036673021531	G1 box; other site
1036673021532	Switch I region; other site
1036673021533	G2 box; other site
1036673021534	G3 box; other site
1036673021535	Switch II region; other site
1036673021536	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1036673021537	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673021538	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673021539	putative Zn2+ binding site [ion binding]; other site
1036673021540	putative DNA binding site [nucleotide binding]; other site
1036673021541	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1036673021542	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673021543	1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137
1036673021544	Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124
1036673021545	Glutamate binding site [chemical binding]; other site
1036673021546	homodimer interface [polypeptide binding]; other site
1036673021547	NAD binding site [chemical binding]; other site
1036673021548	catalytic residues [active]
1036673021549	Proline dehydrogenase; Region: Pro_dh; cl03282
1036673021550	metabolite-proton symporter; Region: 2A0106; TIGR00883
1036673021551	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1036673021552	PAS domain; Region: PAS_9; pfam13426
1036673021553	putative active site [active]
1036673021554	heme pocket [chemical binding]; other site
1036673021555	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1036673021556	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
1036673021557	Walker A motif; other site
1036673021558	ATP binding site [chemical binding]; other site
1036673021559	Walker B motif; other site
1036673021560	arginine finger; other site
1036673021561	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1036673021562	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1036673021563	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673021564	active site
1036673021565	phosphorylation site [posttranslational modification]
1036673021566	intermolecular recognition site; other site
1036673021567	dimerization interface [polypeptide binding]; other site
1036673021568	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1036673021569	DNA binding residues [nucleotide binding]
1036673021570	dimerization interface [polypeptide binding]; other site
1036673021571	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1036673021572	Histidine kinase; Region: HisKA_3; pfam07730
1036673021573	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673021574	ATP binding site [chemical binding]; other site
1036673021575	Mg2+ binding site [ion binding]; other site
1036673021576	G-X-G motif; other site
1036673021577	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1036673021578	pentamer interface [polypeptide binding]; other site
1036673021579	dodecaamer interface [polypeptide binding]; other site
1036673021580	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1036673021581	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1036673021582	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1036673021583	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1036673021584	Coenzyme A binding pocket [chemical binding]; other site
1036673021585	Heat induced stress protein YflT; Region: YflT; pfam11181
1036673021586	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673021587	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673021588	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1036673021589	Walker A/P-loop; other site
1036673021590	ATP binding site [chemical binding]; other site
1036673021591	Q-loop/lid; other site
1036673021592	ABC transporter signature motif; other site
1036673021593	Walker B; other site
1036673021594	D-loop; other site
1036673021595	H-loop/switch region; other site
1036673021596	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
1036673021597	Catalytic site [active]
1036673021598	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
1036673021599	SynChlorMet cassette protein ScmC; Region: SCM_chp_ScmC; TIGR04249
1036673021600	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1036673021601	Fe-S cluster binding site [ion binding]; other site
1036673021602	active site
1036673021603	GAF domain; Region: GAF; cl17456
1036673021604	GAF domain; Region: GAF_2; pfam13185
1036673021605	PAS domain S-box; Region: sensory_box; TIGR00229
1036673021606	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673021607	putative active site [active]
1036673021608	heme pocket [chemical binding]; other site
1036673021609	PAS domain; Region: PAS_9; pfam13426
1036673021610	PAS domain S-box; Region: sensory_box; TIGR00229
1036673021611	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673021612	putative active site [active]
1036673021613	heme pocket [chemical binding]; other site
1036673021614	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673021615	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673021616	metal binding site [ion binding]; metal-binding site
1036673021617	active site
1036673021618	I-site; other site
1036673021619	Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227
1036673021620	Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504
1036673021621	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1036673021622	Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597
1036673021623	active site
1036673021624	Zn binding site [ion binding]; other site
1036673021625	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1036673021626	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
1036673021627	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1036673021628	DEAD_2; Region: DEAD_2; pfam06733
1036673021629	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1036673021630	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1036673021631	MarR family; Region: MarR; pfam01047
1036673021632	lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203
1036673021633	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673021634	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1036673021635	Walker A/P-loop; other site
1036673021636	ATP binding site [chemical binding]; other site
1036673021637	Q-loop/lid; other site
1036673021638	ABC transporter signature motif; other site
1036673021639	Walker B; other site
1036673021640	D-loop; other site
1036673021641	H-loop/switch region; other site
1036673021642	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1036673021643	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1036673021644	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1036673021645	Walker A/P-loop; other site
1036673021646	ATP binding site [chemical binding]; other site
1036673021647	Q-loop/lid; other site
1036673021648	ABC transporter signature motif; other site
1036673021649	Walker B; other site
1036673021650	D-loop; other site
1036673021651	H-loop/switch region; other site
1036673021652	Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381
1036673021653	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1036673021654	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1036673021655	dimerization interface [polypeptide binding]; other site
1036673021656	DPS ferroxidase diiron center [ion binding]; other site
1036673021657	ion pore; other site
1036673021658	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1036673021659	metal binding site 2 [ion binding]; metal-binding site
1036673021660	putative DNA binding helix; other site
1036673021661	metal binding site 1 [ion binding]; metal-binding site
1036673021662	dimer interface [polypeptide binding]; other site
1036673021663	structural Zn2+ binding site [ion binding]; other site
1036673021664	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673021665	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673021666	DNA binding site [nucleotide binding]
1036673021667	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430
1036673021668	Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376
1036673021669	Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458
1036673021670	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1036673021671	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
1036673021672	Probable polygalacturonase At3g15720; Region: PLN03003; cl14103
1036673021673	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
1036673021674	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673021675	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
1036673021676	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
1036673021677	active site
1036673021678	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1036673021679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673021680	dimer interface [polypeptide binding]; other site
1036673021681	conserved gate region; other site
1036673021682	putative PBP binding loops; other site
1036673021683	ABC-ATPase subunit interface; other site
1036673021684	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1036673021685	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673021686	dimer interface [polypeptide binding]; other site
1036673021687	conserved gate region; other site
1036673021688	ABC-ATPase subunit interface; other site
1036673021689	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673021690	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673021691	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673021692	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673021693	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673021694	MAEBL; Provisional; Region: PTZ00121
1036673021695	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1036673021696	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673021697	dimerization interface [polypeptide binding]; other site
1036673021698	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673021699	dimer interface [polypeptide binding]; other site
1036673021700	phosphorylation site [posttranslational modification]
1036673021701	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673021702	ATP binding site [chemical binding]; other site
1036673021703	Mg2+ binding site [ion binding]; other site
1036673021704	G-X-G motif; other site
1036673021705	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673021706	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673021707	active site
1036673021708	phosphorylation site [posttranslational modification]
1036673021709	intermolecular recognition site; other site
1036673021710	dimerization interface [polypeptide binding]; other site
1036673021711	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673021712	DNA binding site [nucleotide binding]
1036673021713	Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530
1036673021714	non-specific DNA binding site [nucleotide binding]; other site
1036673021715	salt bridge; other site
1036673021716	sequence-specific DNA binding site [nucleotide binding]; other site
1036673021717	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1036673021718	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1036673021719	non-specific DNA binding site [nucleotide binding]; other site
1036673021720	salt bridge; other site
1036673021721	sequence-specific DNA binding site [nucleotide binding]; other site
1036673021722	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1036673021723	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1036673021724	Walker A/P-loop; other site
1036673021725	ATP binding site [chemical binding]; other site
1036673021726	Q-loop/lid; other site
1036673021727	ABC transporter signature motif; other site
1036673021728	Walker B; other site
1036673021729	D-loop; other site
1036673021730	H-loop/switch region; other site
1036673021731	PAS domain S-box; Region: sensory_box; TIGR00229
1036673021732	PAS domain; Region: PAS_8; pfam13188
1036673021733	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1036673021734	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1036673021735	metal binding site [ion binding]; metal-binding site
1036673021736	active site
1036673021737	I-site; other site
1036673021738	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1036673021739	Cache domain; Region: Cache_1; pfam02743
1036673021740	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673021741	dimerization interface [polypeptide binding]; other site
1036673021742	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673021743	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673021744	dimer interface [polypeptide binding]; other site
1036673021745	putative CheW interface [polypeptide binding]; other site
1036673021746	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673021747	Interdomain contacts; other site
1036673021748	Cytokine receptor motif; other site
1036673021749	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
1036673021750	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673021751	Interdomain contacts; other site
1036673021752	Cytokine receptor motif; other site
1036673021753	Cold-inducible protein YdjO; Region: YdjO; pfam14169
1036673021754	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
1036673021755	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
1036673021756	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673021757	dimerization interface [polypeptide binding]; other site
1036673021758	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673021759	dimer interface [polypeptide binding]; other site
1036673021760	putative CheW interface [polypeptide binding]; other site
1036673021761	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
1036673021762	glycerol kinase; Provisional; Region: glpK; PRK00047
1036673021763	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1036673021764	N- and C-terminal domain interface [polypeptide binding]; other site
1036673021765	active site
1036673021766	MgATP binding site [chemical binding]; other site
1036673021767	catalytic site [active]
1036673021768	metal binding site [ion binding]; metal-binding site
1036673021769	glycerol binding site [chemical binding]; other site
1036673021770	homotetramer interface [polypeptide binding]; other site
1036673021771	homodimer interface [polypeptide binding]; other site
1036673021772	FBP binding site [chemical binding]; other site
1036673021773	protein IIAGlc interface [polypeptide binding]; other site
1036673021774	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1036673021775	amphipathic channel; other site
1036673021776	Asn-Pro-Ala signature motifs; other site
1036673021777	Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954
1036673021778	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1036673021779	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1036673021780	putative ligand binding residues [chemical binding]; other site
1036673021781	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1036673021782	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1036673021783	Walker A/P-loop; other site
1036673021784	ATP binding site [chemical binding]; other site
1036673021785	Q-loop/lid; other site
1036673021786	ABC transporter signature motif; other site
1036673021787	Walker B; other site
1036673021788	D-loop; other site
1036673021789	H-loop/switch region; other site
1036673021790	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673021791	ABC-ATPase subunit  interface; other site
1036673021792	dimer interface [polypeptide binding]; other site
1036673021793	putative PBP binding regions; other site
1036673021794	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1036673021795	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1036673021796	ABC-ATPase subunit  interface; other site
1036673021797	dimer interface [polypeptide binding]; other site
1036673021798	putative PBP binding regions; other site
1036673021799	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1036673021800	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1036673021801	Uncharacterized conserved protein [Function unknown]; Region: COG2427
1036673021802	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1036673021803	active site
1036673021804	HIGH motif; other site
1036673021805	nucleotide binding site [chemical binding]; other site
1036673021806	active site
1036673021807	KMSKS motif; other site
1036673021808	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1036673021809	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1036673021810	YceI-like domain; Region: YceI; pfam04264
1036673021811	Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219
1036673021812	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1036673021813	short chain dehydrogenase; Provisional; Region: PRK06701
1036673021814	classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355
1036673021815	NAD binding site [chemical binding]; other site
1036673021816	metal binding site [ion binding]; metal-binding site
1036673021817	active site
1036673021818	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1036673021819	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
1036673021820	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673021821	dimerization interface [polypeptide binding]; other site
1036673021822	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1036673021823	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1036673021824	dimer interface [polypeptide binding]; other site
1036673021825	putative CheW interface [polypeptide binding]; other site
1036673021826	Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522
1036673021827	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1036673021828	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
1036673021829	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1036673021830	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1036673021831	Walker A/P-loop; other site
1036673021832	ATP binding site [chemical binding]; other site
1036673021833	Q-loop/lid; other site
1036673021834	ABC transporter signature motif; other site
1036673021835	Walker B; other site
1036673021836	D-loop; other site
1036673021837	H-loop/switch region; other site
1036673021838	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1036673021839	active site
1036673021840	catalytic triad [active]
1036673021841	oxyanion hole [active]
1036673021842	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1036673021843	EamA-like transporter family; Region: EamA; pfam00892
1036673021844	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1036673021845	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1036673021846	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1036673021847	hypothetical protein; Provisional; Region: PRK08236
1036673021848	Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107
1036673021849	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1036673021850	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1036673021851	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1036673021852	S-layer homology domain; Region: SLH; pfam00395
1036673021853	S-layer homology domain; Region: SLH; pfam00395
1036673021854	Axonemal dynein light chain; Region: Ax_dynein_light; pfam10211
1036673021855	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1036673021856	dimerization interface [polypeptide binding]; other site
1036673021857	putative DNA binding site [nucleotide binding]; other site
1036673021858	putative Zn2+ binding site [ion binding]; other site
1036673021859	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1036673021860	putative hydrophobic ligand binding site [chemical binding]; other site
1036673021861	Predicted transcriptional regulator [Transcription]; Region: COG1959
1036673021862	Transcriptional regulator; Region: Rrf2; pfam02082
1036673021863	MMPL family; Region: MMPL; pfam03176
1036673021864	Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409
1036673021865	Domain of unknown function (DUF4132); Region: DUF4132; pfam13569
1036673021866	Periplasmic lysozyme inhibitor, I-type (PliI) and similar proteins; Region: PliI_like; cd09632
1036673021867	dimer interface [polypeptide binding]; other site
1036673021868	putative inhibitory loop; other site
1036673021869	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673021870	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673021871	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673021872	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1036673021873	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1036673021874	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1036673021875	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
1036673021876	tetramer interface [polypeptide binding]; other site
1036673021877	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1036673021878	active site
1036673021879	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
1036673021880	active site
1036673021881	dimer interface [polypeptide binding]; other site
1036673021882	magnesium binding site [ion binding]; other site
1036673021883	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673021884	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673021885	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666
1036673021886	classical (c) SDRs; Region: SDR_c; cd05233
1036673021887	NAD(P) binding site [chemical binding]; other site
1036673021888	active site
1036673021889	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1036673021890	Clade 1 of the heme-binding enzyme catalase; Region: catalase_clade_1; cd08154
1036673021891	tetramer interface [polypeptide binding]; other site
1036673021892	heme binding pocket [chemical binding]; other site
1036673021893	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673021894	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1036673021895	active site
1036673021896	motif I; other site
1036673021897	motif II; other site
1036673021898	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1036673021899	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673021900	S-adenosylmethionine binding site [chemical binding]; other site
1036673021901	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673021902	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1036673021903	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1036673021904	Walker A/P-loop; other site
1036673021905	ATP binding site [chemical binding]; other site
1036673021906	Q-loop/lid; other site
1036673021907	ABC transporter signature motif; other site
1036673021908	Walker B; other site
1036673021909	D-loop; other site
1036673021910	H-loop/switch region; other site
1036673021911	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1036673021912	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1036673021913	dimer interface [polypeptide binding]; other site
1036673021914	conserved gate region; other site
1036673021915	putative PBP binding loops; other site
1036673021916	ABC-ATPase subunit interface; other site
1036673021917	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1036673021918	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1036673021919	substrate binding pocket [chemical binding]; other site
1036673021920	membrane-bound complex binding site; other site
1036673021921	hinge residues; other site
1036673021922	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1036673021923	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1036673021924	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1036673021925	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1036673021926	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
1036673021927	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1036673021928	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1036673021929	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
1036673021930	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1036673021931	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1036673021932	TPR repeat; Region: TPR_11; pfam13414
1036673021933	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1036673021934	active site
1036673021935	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1036673021936	DNA binding site [nucleotide binding]
1036673021937	active site
1036673021938	CsbD-like; Region: CsbD; pfam05532
1036673021939	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
1036673021940	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1036673021941	S-adenosylmethionine binding site [chemical binding]; other site
1036673021942	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
1036673021943	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1036673021944	ATP binding site [chemical binding]; other site
1036673021945	Mg++ binding site [ion binding]; other site
1036673021946	motif III; other site
1036673021947	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673021948	nucleotide binding region [chemical binding]; other site
1036673021949	ATP-binding site [chemical binding]; other site
1036673021950	RNA recognition motif in Bacillus subtilis ATP-dependent RNA helicase YxiN and similar proteins; Region: RRM_BsYxiN_like; cd12500
1036673021951	RNA binding site [nucleotide binding]; other site
1036673021952	Predicted transcriptional regulators [Transcription]; Region: COG1733
1036673021953	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1036673021954	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1036673021955	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673021956	putative substrate translocation pore; other site
1036673021957	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1036673021958	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1036673021959	active site
1036673021960	catalytic tetrad [active]
1036673021961	xanthine permease; Region: pbuX; TIGR03173
1036673021962	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1036673021963	active site
1036673021964	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
1036673021965	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673021966	putative substrate translocation pore; other site
1036673021967	POT family; Region: PTR2; cl17359
1036673021968	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1036673021969	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1036673021970	FeS/SAM binding site; other site
1036673021971	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1036673021972	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1036673021973	putative substrate translocation pore; other site
1036673021974	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1036673021975	GIY-YIG motif/motif A; other site
1036673021976	active site
1036673021977	catalytic site [active]
1036673021978	putative DNA binding site [nucleotide binding]; other site
1036673021979	metal binding site [ion binding]; metal-binding site
1036673021980	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1036673021981	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1036673021982	PhnA protein; Region: PhnA; pfam03831
1036673021983	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1036673021984	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1036673021985	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1036673021986	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1036673021987	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1036673021988	active site
1036673021989	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673021990	Interdomain contacts; other site
1036673021991	Cytokine receptor motif; other site
1036673021992	Fibronectin type 3 domain-containing protein [General function prediction only]; Region: COG3401
1036673021993	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673021994	Interdomain contacts; other site
1036673021995	Cytokine receptor motif; other site
1036673021996	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
1036673021997	Interdomain contacts; other site
1036673021998	Cytokine receptor motif; other site
1036673021999	putative pectinesterase; Region: PLN02432; cl01911
1036673022000	Carbohydrate binding domain X2; Region: CBM_X2; pfam03442
1036673022001	Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866
1036673022002	Amb_all domain; Region: Amb_all; smart00656
1036673022003	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1036673022004	Predicted transcriptional regulator [Transcription]; Region: COG2378
1036673022005	HTH domain; Region: HTH_11; pfam08279
1036673022006	WYL domain; Region: WYL; pfam13280
1036673022007	EVE domain; Region: EVE; cl00728
1036673022008	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
1036673022009	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1036673022010	ATP binding site [chemical binding]; other site
1036673022011	Mg++ binding site [ion binding]; other site
1036673022012	motif III; other site
1036673022013	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1036673022014	nucleotide binding region [chemical binding]; other site
1036673022015	ATP-binding site [chemical binding]; other site
1036673022016	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1036673022017	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1036673022018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673022019	ATP binding site [chemical binding]; other site
1036673022020	Mg2+ binding site [ion binding]; other site
1036673022021	G-X-G motif; other site
1036673022022	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1036673022023	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673022024	active site
1036673022025	phosphorylation site [posttranslational modification]
1036673022026	intermolecular recognition site; other site
1036673022027	dimerization interface [polypeptide binding]; other site
1036673022028	LytTr DNA-binding domain; Region: LytTR; smart00850
1036673022029	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1036673022030	YyzF-like protein; Region: YyzF; pfam14116
1036673022031	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1036673022032	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1036673022033	protein binding site [polypeptide binding]; other site
1036673022034	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1036673022035	YycH protein; Region: YycI; cl02015
1036673022036	YycH protein; Region: YycH; pfam07435
1036673022037	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1036673022038	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1036673022039	dimerization interface [polypeptide binding]; other site
1036673022040	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1036673022041	putative active site [active]
1036673022042	heme pocket [chemical binding]; other site
1036673022043	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1036673022044	dimer interface [polypeptide binding]; other site
1036673022045	phosphorylation site [posttranslational modification]
1036673022046	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1036673022047	ATP binding site [chemical binding]; other site
1036673022048	Mg2+ binding site [ion binding]; other site
1036673022049	G-X-G motif; other site
1036673022050	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1036673022051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1036673022052	active site
1036673022053	phosphorylation site [posttranslational modification]
1036673022054	intermolecular recognition site; other site
1036673022055	dimerization interface [polypeptide binding]; other site
1036673022056	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1036673022057	DNA binding site [nucleotide binding]
1036673022058	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1036673022059	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1036673022060	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1036673022061	G5 domain; Region: G5; pfam07501
1036673022062	Peptidase family M23; Region: Peptidase_M23; pfam01551
1036673022063	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1036673022064	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1036673022065	GDP-binding site [chemical binding]; other site
1036673022066	ACT binding site; other site
1036673022067	IMP binding site; other site
1036673022068	replicative DNA helicase; Provisional; Region: PRK05748
1036673022069	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1036673022070	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1036673022071	Walker A motif; other site
1036673022072	ATP binding site [chemical binding]; other site
1036673022073	Walker B motif; other site
1036673022074	DNA binding loops [nucleotide binding]
1036673022075	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1036673022076	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1036673022077	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1036673022078	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1036673022079	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
1036673022080	DHH family; Region: DHH; pfam01368
1036673022081	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
1036673022082	MazG-like family; Region: MazG-like; pfam12643
1036673022083	FOG: CBS domain [General function prediction only]; Region: COG0517
1036673022084	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
1036673022085	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1036673022086	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1036673022087	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1036673022088	dimer interface [polypeptide binding]; other site
1036673022089	ssDNA binding site [nucleotide binding]; other site
1036673022090	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1036673022091	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1036673022092	YjzC-like protein; Region: YjzC; pfam14168
1036673022093	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
1036673022094	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1036673022095	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1036673022096	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
1036673022097	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
1036673022098	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1036673022099	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1036673022100	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1036673022101	catalytic residue [active]
1036673022102	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1036673022103	ParB-like nuclease domain; Region: ParB; smart00470
1036673022104	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1036673022105	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1036673022106	P-loop; other site
1036673022107	Magnesium ion binding site [ion binding]; other site
1036673022108	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1036673022109	Magnesium ion binding site [ion binding]; other site
1036673022110	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1036673022111	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
1036673022112	ParB-like nuclease domain; Region: ParB; smart00470
1036673022113	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1036673022114	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1036673022115	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1036673022116	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
1036673022117	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1036673022118	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1036673022119	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1036673022120	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1036673022121	G1 box; other site
1036673022122	GTP/Mg2+ binding site [chemical binding]; other site
1036673022123	Switch I region; other site
1036673022124	G2 box; other site
1036673022125	Switch II region; other site
1036673022126	G3 box; other site
1036673022127	G4 box; other site
1036673022128	G5 box; other site
1036673022129	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1036673022130	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1036673022131	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1036673022132	G-X-X-G motif; other site
1036673022133	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1036673022134	RxxxH motif; other site
1036673022135	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
1036673022136	ribonuclease P; Reviewed; Region: rnpA; PRK00499