-- dump date 20140619_225909 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1052684000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1052684000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1052684000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684000004 Walker A motif; other site 1052684000005 ATP binding site [chemical binding]; other site 1052684000006 Walker B motif; other site 1052684000007 arginine finger; other site 1052684000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1052684000009 DnaA box-binding interface [nucleotide binding]; other site 1052684000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 1052684000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1052684000012 putative DNA binding surface [nucleotide binding]; other site 1052684000013 dimer interface [polypeptide binding]; other site 1052684000014 beta-clamp/clamp loader binding surface; other site 1052684000015 beta-clamp/translesion DNA polymerase binding surface; other site 1052684000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052684000017 RNA binding surface [nucleotide binding]; other site 1052684000018 recombination protein F; Reviewed; Region: recF; PRK00064 1052684000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1052684000020 Walker A/P-loop; other site 1052684000021 ATP binding site [chemical binding]; other site 1052684000022 Q-loop/lid; other site 1052684000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684000024 ABC transporter signature motif; other site 1052684000025 Walker B; other site 1052684000026 D-loop; other site 1052684000027 H-loop/switch region; other site 1052684000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1052684000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684000030 Mg2+ binding site [ion binding]; other site 1052684000031 G-X-G motif; other site 1052684000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1052684000033 anchoring element; other site 1052684000034 dimer interface [polypeptide binding]; other site 1052684000035 ATP binding site [chemical binding]; other site 1052684000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1052684000037 active site 1052684000038 putative metal-binding site [ion binding]; other site 1052684000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1052684000040 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1052684000041 DNA gyrase subunit A; Validated; Region: PRK05560 1052684000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1052684000043 CAP-like domain; other site 1052684000044 active site 1052684000045 primary dimer interface [polypeptide binding]; other site 1052684000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052684000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052684000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052684000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052684000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052684000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052684000052 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1052684000053 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052684000054 Zn2+ binding site [ion binding]; other site 1052684000055 Mg2+ binding site [ion binding]; other site 1052684000056 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 1052684000057 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1052684000058 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1052684000059 homodimer interface [polypeptide binding]; other site 1052684000060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684000061 catalytic residue [active] 1052684000062 thymidylate kinase; Validated; Region: tmk; PRK00698 1052684000063 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1052684000064 TMP-binding site; other site 1052684000065 ATP-binding site [chemical binding]; other site 1052684000066 Protein of unknown function (DUF970); Region: DUF970; pfam06153 1052684000067 Protein of unknown function (DUF327); Region: DUF327; pfam03885 1052684000068 DNA polymerase III subunit delta'; Validated; Region: PRK08058 1052684000069 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1052684000070 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 1052684000071 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1052684000072 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1052684000073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684000074 S-adenosylmethionine binding site [chemical binding]; other site 1052684000075 Predicted methyltransferases [General function prediction only]; Region: COG0313 1052684000076 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1052684000077 putative SAM binding site [chemical binding]; other site 1052684000078 putative homodimer interface [polypeptide binding]; other site 1052684000079 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1052684000080 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1052684000081 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052684000082 Zn2+ binding site [ion binding]; other site 1052684000083 Mg2+ binding site [ion binding]; other site 1052684000084 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1052684000085 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1052684000086 active site 1052684000087 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1052684000088 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1052684000089 G5 domain; Region: G5; pfam07501 1052684000090 3D domain; Region: 3D; cl01439 1052684000091 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1052684000092 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1052684000093 putative active site [active] 1052684000094 putative metal binding site [ion binding]; other site 1052684000095 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1052684000096 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1052684000097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684000098 S-adenosylmethionine binding site [chemical binding]; other site 1052684000099 YabG peptidase U57; Region: Peptidase_U57; cl05250 1052684000100 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 1052684000101 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052684000102 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 1052684000103 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1052684000104 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052684000105 pur operon repressor; Provisional; Region: PRK09213 1052684000106 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1052684000107 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052684000108 active site 1052684000109 regulatory protein SpoVG; Reviewed; Region: PRK13259 1052684000110 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1052684000111 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1052684000112 Substrate binding site; other site 1052684000113 Mg++ binding site; other site 1052684000114 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1052684000115 active site 1052684000116 substrate binding site [chemical binding]; other site 1052684000117 CoA binding site [chemical binding]; other site 1052684000118 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1052684000119 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1052684000120 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052684000121 active site 1052684000122 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1052684000123 putative active site [active] 1052684000124 catalytic residue [active] 1052684000125 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 1052684000126 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1052684000127 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1052684000128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052684000129 ATP binding site [chemical binding]; other site 1052684000130 putative Mg++ binding site [ion binding]; other site 1052684000131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684000132 nucleotide binding region [chemical binding]; other site 1052684000133 ATP-binding site [chemical binding]; other site 1052684000134 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1052684000135 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 1052684000136 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 1052684000137 stage V sporulation protein T; Region: spore_V_T; TIGR02851 1052684000138 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 1052684000139 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1052684000140 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 1052684000141 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 1052684000142 putative SAM binding site [chemical binding]; other site 1052684000143 putative homodimer interface [polypeptide binding]; other site 1052684000144 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1052684000145 homodimer interface [polypeptide binding]; other site 1052684000146 metal binding site [ion binding]; metal-binding site 1052684000147 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1052684000148 homodimer interface [polypeptide binding]; other site 1052684000149 active site 1052684000150 putative chemical substrate binding site [chemical binding]; other site 1052684000151 metal binding site [ion binding]; metal-binding site 1052684000152 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1052684000153 IHF dimer interface [polypeptide binding]; other site 1052684000154 IHF - DNA interface [nucleotide binding]; other site 1052684000155 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052684000156 RNA binding surface [nucleotide binding]; other site 1052684000157 YabP family; Region: YabP; cl06766 1052684000158 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 1052684000159 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1052684000160 Septum formation initiator; Region: DivIC; cl17659 1052684000161 hypothetical protein; Provisional; Region: PRK08582 1052684000162 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1052684000163 RNA binding site [nucleotide binding]; other site 1052684000164 stage II sporulation protein E; Region: spore_II_E; TIGR02865 1052684000165 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1052684000166 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1052684000167 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052684000168 active site 1052684000169 ATP binding site [chemical binding]; other site 1052684000170 substrate binding site [chemical binding]; other site 1052684000171 activation loop (A-loop); other site 1052684000172 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1052684000173 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1052684000174 Ligand Binding Site [chemical binding]; other site 1052684000175 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1052684000176 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052684000177 active site 1052684000178 FtsH Extracellular; Region: FtsH_ext; pfam06480 1052684000179 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1052684000180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684000181 Walker A motif; other site 1052684000182 ATP binding site [chemical binding]; other site 1052684000183 Walker B motif; other site 1052684000184 arginine finger; other site 1052684000185 Peptidase family M41; Region: Peptidase_M41; pfam01434 1052684000186 L-aspartate oxidase; Provisional; Region: PRK06175 1052684000187 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1052684000188 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1052684000189 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1052684000190 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1052684000191 dimerization interface [polypeptide binding]; other site 1052684000192 active site 1052684000193 pantothenate kinase; Reviewed; Region: PRK13318 1052684000194 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1052684000195 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1052684000196 dimerization interface [polypeptide binding]; other site 1052684000197 domain crossover interface; other site 1052684000198 redox-dependent activation switch; other site 1052684000199 SurA N-terminal domain; Region: SurA_N_3; cl07813 1052684000200 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1052684000201 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1052684000202 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052684000203 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052684000204 dimer interface [polypeptide binding]; other site 1052684000205 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684000206 catalytic residue [active] 1052684000207 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 1052684000208 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1052684000209 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1052684000210 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1052684000211 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1052684000212 glutamine binding [chemical binding]; other site 1052684000213 catalytic triad [active] 1052684000214 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1052684000215 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 1052684000216 homodimer interface [polypeptide binding]; other site 1052684000217 substrate-cofactor binding pocket; other site 1052684000218 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684000219 catalytic residue [active] 1052684000220 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1052684000221 dihydropteroate synthase; Region: DHPS; TIGR01496 1052684000222 substrate binding pocket [chemical binding]; other site 1052684000223 dimer interface [polypeptide binding]; other site 1052684000224 inhibitor binding site; inhibition site 1052684000225 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1052684000226 homooctamer interface [polypeptide binding]; other site 1052684000227 active site 1052684000228 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1052684000229 catalytic center binding site [active] 1052684000230 ATP binding site [chemical binding]; other site 1052684000231 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1052684000232 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1052684000233 FMN binding site [chemical binding]; other site 1052684000234 active site 1052684000235 catalytic residues [active] 1052684000236 substrate binding site [chemical binding]; other site 1052684000237 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1052684000238 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1052684000239 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1052684000240 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1052684000241 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1052684000242 dimer interface [polypeptide binding]; other site 1052684000243 putative anticodon binding site; other site 1052684000244 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1052684000245 motif 1; other site 1052684000246 active site 1052684000247 motif 2; other site 1052684000248 motif 3; other site 1052684000249 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1052684000250 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1052684000251 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1052684000252 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1052684000253 NAD binding site [chemical binding]; other site 1052684000254 homotetramer interface [polypeptide binding]; other site 1052684000255 homodimer interface [polypeptide binding]; other site 1052684000256 substrate binding site [chemical binding]; other site 1052684000257 active site 1052684000258 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052684000259 AMP-binding enzyme; Region: AMP-binding; pfam00501 1052684000260 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 1052684000261 acyl-activating enzyme (AAE) consensus motif; other site 1052684000262 acyl-activating enzyme (AAE) consensus motif; other site 1052684000263 AMP binding site [chemical binding]; other site 1052684000264 active site 1052684000265 CoA binding site [chemical binding]; other site 1052684000266 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1052684000267 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1052684000268 catalytic residues [active] 1052684000269 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 1052684000270 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052684000271 PYR/PP interface [polypeptide binding]; other site 1052684000272 dimer interface [polypeptide binding]; other site 1052684000273 TPP binding site [chemical binding]; other site 1052684000274 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1052684000275 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 1052684000276 TPP-binding site [chemical binding]; other site 1052684000277 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Region: TPP_enzyme_C; pfam02775 1052684000278 TPP-binding site [chemical binding]; other site 1052684000279 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1052684000280 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1052684000281 dimer interface [polypeptide binding]; other site 1052684000282 active site 1052684000283 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1052684000284 Condensation domain; Region: Condensation; pfam00668 1052684000285 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684000286 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684000287 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684000288 acyl-activating enzyme (AAE) consensus motif; other site 1052684000289 AMP binding site [chemical binding]; other site 1052684000290 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684000291 peptide synthase; Provisional; Region: PRK12316 1052684000292 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684000293 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052684000294 acyl-activating enzyme (AAE) consensus motif; other site 1052684000295 AMP binding site [chemical binding]; other site 1052684000296 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684000297 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684000298 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684000299 acyl-activating enzyme (AAE) consensus motif; other site 1052684000300 AMP binding site [chemical binding]; other site 1052684000301 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684000302 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684000303 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684000304 acyl-activating enzyme (AAE) consensus motif; other site 1052684000305 AMP binding site [chemical binding]; other site 1052684000306 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684000307 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684000308 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684000309 acyl-activating enzyme (AAE) consensus motif; other site 1052684000310 AMP binding site [chemical binding]; other site 1052684000311 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684000312 Condensation domain; Region: Condensation; pfam00668 1052684000313 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684000314 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684000315 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1052684000316 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684000317 acyl-activating enzyme (AAE) consensus motif; other site 1052684000318 AMP binding site [chemical binding]; other site 1052684000319 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684000320 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052684000321 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1052684000322 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1052684000323 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1052684000324 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1052684000325 active site 1052684000326 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1052684000327 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1052684000328 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1052684000329 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1052684000330 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1052684000331 active site 1052684000332 multimer interface [polypeptide binding]; other site 1052684000333 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1052684000334 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 1052684000335 predicted active site [active] 1052684000336 catalytic triad [active] 1052684000337 seryl-tRNA synthetase; Provisional; Region: PRK05431 1052684000338 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1052684000339 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1052684000340 dimer interface [polypeptide binding]; other site 1052684000341 active site 1052684000342 motif 1; other site 1052684000343 motif 2; other site 1052684000344 motif 3; other site 1052684000345 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052684000346 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052684000347 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1052684000348 nucleoside/Zn binding site; other site 1052684000349 dimer interface [polypeptide binding]; other site 1052684000350 catalytic motif [active] 1052684000351 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684000352 dimerization interface [polypeptide binding]; other site 1052684000353 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1052684000354 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052684000355 putative active site [active] 1052684000356 heme pocket [chemical binding]; other site 1052684000357 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684000358 dimer interface [polypeptide binding]; other site 1052684000359 phosphorylation site [posttranslational modification] 1052684000360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684000361 ATP binding site [chemical binding]; other site 1052684000362 Mg2+ binding site [ion binding]; other site 1052684000363 G-X-G motif; other site 1052684000364 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1052684000365 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052684000366 RNA binding surface [nucleotide binding]; other site 1052684000367 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1052684000368 probable active site [active] 1052684000369 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 1052684000370 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1052684000371 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1052684000372 ligand binding site [chemical binding]; other site 1052684000373 flagellar motor protein MotA; Validated; Region: PRK08124 1052684000374 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1052684000375 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 1052684000376 aromatic arch; other site 1052684000377 DCoH dimer interaction site [polypeptide binding]; other site 1052684000378 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 1052684000379 DCoH tetramer interaction site [polypeptide binding]; other site 1052684000380 substrate binding site [chemical binding]; other site 1052684000381 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052684000382 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052684000383 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052684000384 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 1052684000385 Zn binding site [ion binding]; other site 1052684000386 YwhD family; Region: YwhD; pfam08741 1052684000387 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052684000388 HPr interaction site; other site 1052684000389 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052684000390 active site 1052684000391 phosphorylation site [posttranslational modification] 1052684000392 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052684000393 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1052684000394 catalytic core [active] 1052684000395 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1052684000396 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052684000397 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052684000398 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1052684000399 dimer interface [polypeptide binding]; other site 1052684000400 Transglycosylase; Region: Transgly; pfam00912 1052684000401 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052684000402 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1052684000403 spermidine synthase; Provisional; Region: PRK00811 1052684000404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684000405 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052684000406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684000407 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684000408 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684000409 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1052684000410 Walker A/P-loop; other site 1052684000411 ATP binding site [chemical binding]; other site 1052684000412 Q-loop/lid; other site 1052684000413 ABC transporter signature motif; other site 1052684000414 Walker B; other site 1052684000415 D-loop; other site 1052684000416 H-loop/switch region; other site 1052684000417 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684000418 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684000419 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684000420 Walker A/P-loop; other site 1052684000421 ATP binding site [chemical binding]; other site 1052684000422 Q-loop/lid; other site 1052684000423 ABC transporter signature motif; other site 1052684000424 Walker B; other site 1052684000425 D-loop; other site 1052684000426 H-loop/switch region; other site 1052684000427 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684000428 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684000429 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684000430 dimerization interface [polypeptide binding]; other site 1052684000431 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1052684000432 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1052684000433 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1052684000434 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1052684000435 active site 1052684000436 HIGH motif; other site 1052684000437 KMSK motif region; other site 1052684000438 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1052684000439 tRNA binding surface [nucleotide binding]; other site 1052684000440 anticodon binding site; other site 1052684000441 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684000442 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684000443 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1052684000444 putative dimerization interface [polypeptide binding]; other site 1052684000445 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1052684000446 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684000447 Walker A/P-loop; other site 1052684000448 ATP binding site [chemical binding]; other site 1052684000449 Q-loop/lid; other site 1052684000450 ABC transporter signature motif; other site 1052684000451 Walker B; other site 1052684000452 D-loop; other site 1052684000453 H-loop/switch region; other site 1052684000454 TOBE domain; Region: TOBE_2; pfam08402 1052684000455 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1052684000456 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1052684000457 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1052684000458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684000459 dimer interface [polypeptide binding]; other site 1052684000460 conserved gate region; other site 1052684000461 putative PBP binding loops; other site 1052684000462 ABC-ATPase subunit interface; other site 1052684000463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684000464 dimer interface [polypeptide binding]; other site 1052684000465 conserved gate region; other site 1052684000466 putative PBP binding loops; other site 1052684000467 ABC-ATPase subunit interface; other site 1052684000468 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 1052684000469 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1052684000470 Beta-Casp domain; Region: Beta-Casp; smart01027 1052684000471 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1052684000472 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1052684000473 active site 1052684000474 catalytic residues [active] 1052684000475 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 1052684000476 CTP synthetase; Validated; Region: pyrG; PRK05380 1052684000477 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1052684000478 Catalytic site [active] 1052684000479 active site 1052684000480 UTP binding site [chemical binding]; other site 1052684000481 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1052684000482 active site 1052684000483 putative oxyanion hole; other site 1052684000484 catalytic triad [active] 1052684000485 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684000486 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684000487 active site 1052684000488 phosphorylation site [posttranslational modification] 1052684000489 intermolecular recognition site; other site 1052684000490 dimerization interface [polypeptide binding]; other site 1052684000491 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1052684000492 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1052684000493 intersubunit interface [polypeptide binding]; other site 1052684000494 active site 1052684000495 zinc binding site [ion binding]; other site 1052684000496 Na+ binding site [ion binding]; other site 1052684000497 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1052684000498 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1052684000499 hinge; other site 1052684000500 active site 1052684000501 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1052684000502 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 1052684000503 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1052684000504 RNA binding site [nucleotide binding]; other site 1052684000505 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1052684000506 Walker A motif; other site 1052684000507 ATP binding site [chemical binding]; other site 1052684000508 Walker B motif; other site 1052684000509 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684000510 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1052684000511 FeS/SAM binding site; other site 1052684000512 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1052684000513 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1052684000514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684000515 Walker A motif; other site 1052684000516 ATP binding site [chemical binding]; other site 1052684000517 Walker B motif; other site 1052684000518 arginine finger; other site 1052684000519 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1052684000520 hypothetical protein; Validated; Region: PRK00153 1052684000521 recombination protein RecR; Reviewed; Region: recR; PRK00076 1052684000522 RecR protein; Region: RecR; pfam02132 1052684000523 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1052684000524 putative active site [active] 1052684000525 putative metal-binding site [ion binding]; other site 1052684000526 tetramer interface [polypeptide binding]; other site 1052684000527 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1052684000528 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1052684000529 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1052684000530 Walker A/P-loop; other site 1052684000531 ATP binding site [chemical binding]; other site 1052684000532 Q-loop/lid; other site 1052684000533 ABC transporter signature motif; other site 1052684000534 Walker B; other site 1052684000535 D-loop; other site 1052684000536 H-loop/switch region; other site 1052684000537 TOBE domain; Region: TOBE; pfam03459 1052684000538 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1052684000539 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1052684000540 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1052684000541 Hpr binding site; other site 1052684000542 active site 1052684000543 homohexamer subunit interaction site [polypeptide binding]; other site 1052684000544 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1052684000545 pyrophosphatase PpaX; Provisional; Region: PRK13288 1052684000546 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684000547 active site 1052684000548 motif I; other site 1052684000549 motif II; other site 1052684000550 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1052684000551 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1052684000552 trimer interface [polypeptide binding]; other site 1052684000553 active site 1052684000554 substrate binding site [chemical binding]; other site 1052684000555 CoA binding site [chemical binding]; other site 1052684000556 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1052684000557 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1052684000558 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 1052684000559 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1052684000560 dimer interface [polypeptide binding]; other site 1052684000561 motif 1; other site 1052684000562 active site 1052684000563 motif 2; other site 1052684000564 motif 3; other site 1052684000565 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 1052684000566 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 1052684000567 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1052684000568 histidinol dehydrogenase; Region: hisD; TIGR00069 1052684000569 NAD binding site [chemical binding]; other site 1052684000570 dimerization interface [polypeptide binding]; other site 1052684000571 product binding site; other site 1052684000572 substrate binding site [chemical binding]; other site 1052684000573 zinc binding site [ion binding]; other site 1052684000574 catalytic residues [active] 1052684000575 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1052684000576 putative active site pocket [active] 1052684000577 4-fold oligomerization interface [polypeptide binding]; other site 1052684000578 metal binding residues [ion binding]; metal-binding site 1052684000579 3-fold/trimer interface [polypeptide binding]; other site 1052684000580 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1052684000581 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1052684000582 putative active site [active] 1052684000583 oxyanion strand; other site 1052684000584 catalytic triad [active] 1052684000585 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1052684000586 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1052684000587 catalytic residues [active] 1052684000588 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1052684000589 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1052684000590 substrate binding site [chemical binding]; other site 1052684000591 glutamase interaction surface [polypeptide binding]; other site 1052684000592 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1052684000593 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1052684000594 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1052684000595 metal binding site [ion binding]; metal-binding site 1052684000596 histidinol-phosphatase; Provisional; Region: PRK07328 1052684000597 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1052684000598 active site 1052684000599 dimer interface [polypeptide binding]; other site 1052684000600 TPR repeat; Region: TPR_11; pfam13414 1052684000601 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052684000602 TPR motif; other site 1052684000603 binding surface 1052684000604 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052684000605 TPR motif; other site 1052684000606 binding surface 1052684000607 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1052684000608 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052684000609 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684000610 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1052684000611 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052684000612 nucleotide binding site [chemical binding]; other site 1052684000613 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1052684000614 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1052684000615 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1052684000616 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1052684000617 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1052684000618 phosphate binding site [ion binding]; other site 1052684000619 putative substrate binding pocket [chemical binding]; other site 1052684000620 dimer interface [polypeptide binding]; other site 1052684000621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1052684000622 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1052684000623 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052684000624 dimerization domain swap beta strand [polypeptide binding]; other site 1052684000625 regulatory protein interface [polypeptide binding]; other site 1052684000626 active site 1052684000627 regulatory phosphorylation site [posttranslational modification]; other site 1052684000628 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 1052684000629 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684000630 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1052684000631 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 1052684000632 Clp protease; Region: CLP_protease; pfam00574 1052684000633 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1052684000634 oligomer interface [polypeptide binding]; other site 1052684000635 active site residues [active] 1052684000636 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1052684000637 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1052684000638 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1052684000639 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1052684000640 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1052684000641 Phosphoglycerate kinase; Region: PGK; pfam00162 1052684000642 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1052684000643 substrate binding site [chemical binding]; other site 1052684000644 hinge regions; other site 1052684000645 ADP binding site [chemical binding]; other site 1052684000646 catalytic site [active] 1052684000647 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1052684000648 triosephosphate isomerase; Provisional; Region: PRK14565 1052684000649 substrate binding site [chemical binding]; other site 1052684000650 dimer interface [polypeptide binding]; other site 1052684000651 catalytic triad [active] 1052684000652 phosphoglyceromutase; Provisional; Region: PRK05434 1052684000653 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1052684000654 enolase; Provisional; Region: eno; PRK00077 1052684000655 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1052684000656 dimer interface [polypeptide binding]; other site 1052684000657 metal binding site [ion binding]; metal-binding site 1052684000658 substrate binding pocket [chemical binding]; other site 1052684000659 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1052684000660 ribonuclease R; Region: RNase_R; TIGR02063 1052684000661 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1052684000662 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1052684000663 RNB domain; Region: RNB; pfam00773 1052684000664 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1052684000665 RNA binding site [nucleotide binding]; other site 1052684000666 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1052684000667 SmpB-tmRNA interface; other site 1052684000668 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1052684000669 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1052684000670 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1052684000671 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052684000672 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052684000673 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1052684000674 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052684000675 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1052684000676 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1052684000677 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1052684000678 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684000679 FeS/SAM binding site; other site 1052684000680 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1052684000681 Ligand Binding Site [chemical binding]; other site 1052684000682 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 1052684000683 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1052684000684 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1052684000685 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1052684000686 Part of AAA domain; Region: AAA_19; pfam13245 1052684000687 Family description; Region: UvrD_C_2; pfam13538 1052684000688 hypothetical protein; Reviewed; Region: PRK00024 1052684000689 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1052684000690 MPN+ (JAMM) motif; other site 1052684000691 Zinc-binding site [ion binding]; other site 1052684000692 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684000693 non-specific DNA binding site [nucleotide binding]; other site 1052684000694 salt bridge; other site 1052684000695 sequence-specific DNA binding site [nucleotide binding]; other site 1052684000696 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684000697 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684000698 D5 N terminal like; Region: D5_N; pfam08706 1052684000699 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 1052684000700 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1052684000701 Int/Topo IB signature motif; other site 1052684000702 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1052684000703 oligomeric interface; other site 1052684000704 putative active site [active] 1052684000705 homodimer interface [polypeptide binding]; other site 1052684000706 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1052684000707 active site 1052684000708 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1052684000709 dimer interface [polypeptide binding]; other site 1052684000710 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1052684000711 Ligand Binding Site [chemical binding]; other site 1052684000712 Molecular Tunnel; other site 1052684000713 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1052684000714 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1052684000715 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684000716 S-adenosylmethionine binding site [chemical binding]; other site 1052684000717 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1052684000718 Cupin-like domain; Region: Cupin_8; pfam13621 1052684000719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684000720 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684000721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684000722 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684000723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684000724 Coenzyme A binding pocket [chemical binding]; other site 1052684000725 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1052684000726 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1052684000727 P-loop; other site 1052684000728 Magnesium ion binding site [ion binding]; other site 1052684000729 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1052684000730 Magnesium ion binding site [ion binding]; other site 1052684000731 putative transposase OrfB; Reviewed; Region: PHA02517 1052684000732 HTH-like domain; Region: HTH_21; pfam13276 1052684000733 Integrase core domain; Region: rve; pfam00665 1052684000734 Integrase core domain; Region: rve_3; pfam13683 1052684000735 Homeodomain-like domain; Region: HTH_23; cl17451 1052684000736 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1052684000737 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 1052684000738 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1052684000739 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052684000740 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052684000741 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052684000742 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1052684000743 Protein of unknown function, DUF600; Region: DUF600; cl04640 1052684000744 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1052684000745 Predicted membrane protein [Function unknown]; Region: COG2259 1052684000746 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052684000747 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052684000748 Zn binding site [ion binding]; other site 1052684000749 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052684000750 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052684000751 Zn binding site [ion binding]; other site 1052684000752 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1052684000753 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1052684000754 active site 1052684000755 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 1052684000756 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684000757 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052684000758 DNA-binding site [nucleotide binding]; DNA binding site 1052684000759 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1052684000760 putative phosphoketolase; Provisional; Region: PRK05261 1052684000761 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1052684000762 TPP-binding site; other site 1052684000763 XFP C-terminal domain; Region: XFP_C; pfam09363 1052684000764 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1052684000765 catalytic tetrad [active] 1052684000766 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052684000767 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052684000768 active site 1052684000769 catalytic tetrad [active] 1052684000770 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1052684000771 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 1052684000772 Repair protein; Region: Repair_PSII; pfam04536 1052684000773 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1052684000774 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 1052684000775 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1052684000776 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1052684000777 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1052684000778 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1052684000779 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1052684000780 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684000781 Phytase; Region: Phytase; cl17685 1052684000782 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684000783 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684000784 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1052684000785 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1052684000786 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1052684000787 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1052684000788 MATE family multidrug exporter; Provisional; Region: PRK10189 1052684000789 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1052684000790 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1052684000791 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1052684000792 NAD(P) binding site [chemical binding]; other site 1052684000793 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684000794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684000795 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1052684000796 putative dimerization interface [polypeptide binding]; other site 1052684000797 RDD family; Region: RDD; pfam06271 1052684000798 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1052684000799 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1052684000800 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684000801 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684000802 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1052684000803 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 1052684000804 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1052684000805 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684000806 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684000807 DNA binding residues [nucleotide binding] 1052684000808 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1052684000809 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1052684000810 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1052684000811 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1052684000812 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1052684000813 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1052684000814 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684000815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684000816 dimer interface [polypeptide binding]; other site 1052684000817 conserved gate region; other site 1052684000818 putative PBP binding loops; other site 1052684000819 ABC-ATPase subunit interface; other site 1052684000820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684000821 dimer interface [polypeptide binding]; other site 1052684000822 conserved gate region; other site 1052684000823 putative PBP binding loops; other site 1052684000824 ABC-ATPase subunit interface; other site 1052684000825 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684000826 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1052684000827 dimerization interface [polypeptide binding]; other site 1052684000828 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052684000829 Histidine kinase; Region: His_kinase; pfam06580 1052684000830 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1052684000831 ATP binding site [chemical binding]; other site 1052684000832 Mg2+ binding site [ion binding]; other site 1052684000833 G-X-G motif; other site 1052684000834 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1052684000835 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684000836 active site 1052684000837 phosphorylation site [posttranslational modification] 1052684000838 intermolecular recognition site; other site 1052684000839 dimerization interface [polypeptide binding]; other site 1052684000840 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684000841 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1052684000842 AAA domain; Region: AAA_18; pfam13238 1052684000843 ATP-binding site [chemical binding]; other site 1052684000844 Sugar specificity; other site 1052684000845 Pyrimidine base specificity; other site 1052684000846 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1052684000847 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1052684000848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684000849 NAD(P) binding site [chemical binding]; other site 1052684000850 active site 1052684000851 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684000852 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684000853 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684000854 dimerization interface [polypeptide binding]; other site 1052684000855 Integrase core domain; Region: rve; pfam00665 1052684000856 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684000857 MarR family; Region: MarR; pfam01047 1052684000858 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684000859 Coenzyme A binding pocket [chemical binding]; other site 1052684000860 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684000861 SNF2 Helicase protein; Region: DUF3670; pfam12419 1052684000862 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1052684000863 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052684000864 ATP binding site [chemical binding]; other site 1052684000865 putative Mg++ binding site [ion binding]; other site 1052684000866 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684000867 nucleotide binding region [chemical binding]; other site 1052684000868 ATP-binding site [chemical binding]; other site 1052684000869 SWIM zinc finger; Region: SWIM; pfam04434 1052684000870 Spore germination protein; Region: Spore_permease; cl17796 1052684000871 Spore germination protein; Region: Spore_permease; cl17796 1052684000872 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052684000873 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052684000874 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052684000875 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1052684000876 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684000877 motif II; other site 1052684000878 maltose phosphorylase; Provisional; Region: PRK13807 1052684000879 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1052684000880 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1052684000881 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1052684000882 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684000883 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684000884 DNA binding site [nucleotide binding] 1052684000885 domain linker motif; other site 1052684000886 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1052684000887 putative dimerization interface [polypeptide binding]; other site 1052684000888 putative ligand binding site [chemical binding]; other site 1052684000889 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 1052684000890 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684000891 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052684000892 active site turn [active] 1052684000893 phosphorylation site [posttranslational modification] 1052684000894 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 1052684000895 putative catalytic site [active] 1052684000896 putative metal binding site [ion binding]; other site 1052684000897 putative phosphate binding site [ion binding]; other site 1052684000898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684000899 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684000900 putative substrate translocation pore; other site 1052684000901 DinB superfamily; Region: DinB_2; pfam12867 1052684000902 hypothetical protein; Provisional; Region: PRK08244 1052684000903 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1052684000904 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1052684000905 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684000906 MarR family; Region: MarR; pfam01047 1052684000907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684000908 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684000909 active site 1052684000910 phosphorylation site [posttranslational modification] 1052684000911 intermolecular recognition site; other site 1052684000912 dimerization interface [polypeptide binding]; other site 1052684000913 YcbB domain; Region: YcbB; pfam08664 1052684000914 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684000915 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684000916 ATP binding site [chemical binding]; other site 1052684000917 Mg2+ binding site [ion binding]; other site 1052684000918 G-X-G motif; other site 1052684000919 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052684000920 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 1052684000921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052684000922 PAS fold; Region: PAS_3; pfam08447 1052684000923 putative active site [active] 1052684000924 heme pocket [chemical binding]; other site 1052684000925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052684000926 PAS fold; Region: PAS_3; pfam08447 1052684000927 putative active site [active] 1052684000928 heme pocket [chemical binding]; other site 1052684000929 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684000930 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684000931 dimer interface [polypeptide binding]; other site 1052684000932 putative CheW interface [polypeptide binding]; other site 1052684000933 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1052684000934 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052684000935 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684000936 ABC-ATPase subunit interface; other site 1052684000937 dimer interface [polypeptide binding]; other site 1052684000938 putative PBP binding regions; other site 1052684000939 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684000940 Coenzyme A binding pocket [chemical binding]; other site 1052684000941 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684000942 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684000943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684000944 dimer interface [polypeptide binding]; other site 1052684000945 conserved gate region; other site 1052684000946 putative PBP binding loops; other site 1052684000947 ABC-ATPase subunit interface; other site 1052684000948 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684000949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684000950 dimer interface [polypeptide binding]; other site 1052684000951 conserved gate region; other site 1052684000952 putative PBP binding loops; other site 1052684000953 ABC-ATPase subunit interface; other site 1052684000954 Cupin domain; Region: Cupin_2; pfam07883 1052684000955 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684000956 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684000957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684000958 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052684000959 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684000960 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052684000961 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 1052684000962 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 1052684000963 active site 1052684000964 zinc binding site [ion binding]; other site 1052684000965 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1052684000966 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1052684000967 NAD binding site [chemical binding]; other site 1052684000968 substrate binding site [chemical binding]; other site 1052684000969 catalytic Zn binding site [ion binding]; other site 1052684000970 tetramer interface [polypeptide binding]; other site 1052684000971 structural Zn binding site [ion binding]; other site 1052684000972 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684000973 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052684000974 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052684000975 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684000976 putative substrate translocation pore; other site 1052684000977 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052684000978 active site 1052684000979 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052684000980 catalytic tetrad [active] 1052684000981 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684000982 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684000983 DNA binding site [nucleotide binding] 1052684000984 domain linker motif; other site 1052684000985 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1052684000986 dimerization interface [polypeptide binding]; other site 1052684000987 ligand binding site [chemical binding]; other site 1052684000988 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1052684000989 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052684000990 substrate binding [chemical binding]; other site 1052684000991 active site 1052684000992 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052684000993 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1052684000994 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052684000995 active site turn [active] 1052684000996 phosphorylation site [posttranslational modification] 1052684000997 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684000998 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684000999 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684001000 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684001001 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1052684001002 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1052684001003 domain interfaces; other site 1052684001004 active site 1052684001005 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1052684001006 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1052684001007 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1052684001008 substrate binding site [chemical binding]; other site 1052684001009 active site 1052684001010 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1052684001011 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1052684001012 DNA-binding site [nucleotide binding]; DNA binding site 1052684001013 RNA-binding motif; other site 1052684001014 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052684001015 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 1052684001016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684001017 Coenzyme A binding pocket [chemical binding]; other site 1052684001018 Predicted transcriptional regulators [Transcription]; Region: COG1725 1052684001019 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684001020 DNA-binding site [nucleotide binding]; DNA binding site 1052684001021 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1052684001022 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052684001023 Walker A/P-loop; other site 1052684001024 ATP binding site [chemical binding]; other site 1052684001025 Q-loop/lid; other site 1052684001026 ABC transporter signature motif; other site 1052684001027 Walker B; other site 1052684001028 D-loop; other site 1052684001029 H-loop/switch region; other site 1052684001030 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1052684001031 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 1052684001032 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684001033 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1052684001034 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1052684001035 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684001036 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684001037 DNA binding site [nucleotide binding] 1052684001038 domain linker motif; other site 1052684001039 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052684001040 dimerization interface [polypeptide binding]; other site 1052684001041 ligand binding site [chemical binding]; other site 1052684001042 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1052684001043 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1052684001044 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1052684001045 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1052684001046 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684001047 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684001048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001049 dimer interface [polypeptide binding]; other site 1052684001050 conserved gate region; other site 1052684001051 putative PBP binding loops; other site 1052684001052 ABC-ATPase subunit interface; other site 1052684001053 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684001054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001055 dimer interface [polypeptide binding]; other site 1052684001056 conserved gate region; other site 1052684001057 putative PBP binding loops; other site 1052684001058 ABC-ATPase subunit interface; other site 1052684001059 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052684001060 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1052684001061 Walker A/P-loop; other site 1052684001062 ATP binding site [chemical binding]; other site 1052684001063 Q-loop/lid; other site 1052684001064 ABC transporter signature motif; other site 1052684001065 Walker B; other site 1052684001066 D-loop; other site 1052684001067 H-loop/switch region; other site 1052684001068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684001069 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1052684001070 Walker A/P-loop; other site 1052684001071 ATP binding site [chemical binding]; other site 1052684001072 Q-loop/lid; other site 1052684001073 ABC transporter signature motif; other site 1052684001074 Walker B; other site 1052684001075 D-loop; other site 1052684001076 H-loop/switch region; other site 1052684001077 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1052684001078 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1052684001079 HSP90 family protein; Provisional; Region: PRK14083 1052684001080 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684001081 ATP binding site [chemical binding]; other site 1052684001082 G-X-G motif; other site 1052684001083 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1052684001084 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 1052684001085 active site 1052684001086 catalytic site [active] 1052684001087 metal binding site [ion binding]; metal-binding site 1052684001088 dimer interface [polypeptide binding]; other site 1052684001089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684001090 S-adenosylmethionine binding site [chemical binding]; other site 1052684001091 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052684001092 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1052684001093 active site 1052684001094 tetramer interface; other site 1052684001095 Predicted membrane protein [Function unknown]; Region: COG2246 1052684001096 GtrA-like protein; Region: GtrA; pfam04138 1052684001097 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1052684001098 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1052684001099 Ligand binding site; other site 1052684001100 Putative Catalytic site; other site 1052684001101 DXD motif; other site 1052684001102 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1052684001103 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1052684001104 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684001105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684001106 active site 1052684001107 phosphorylation site [posttranslational modification] 1052684001108 intermolecular recognition site; other site 1052684001109 dimerization interface [polypeptide binding]; other site 1052684001110 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684001111 DNA binding site [nucleotide binding] 1052684001112 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684001113 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684001114 dimerization interface [polypeptide binding]; other site 1052684001115 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684001116 dimer interface [polypeptide binding]; other site 1052684001117 phosphorylation site [posttranslational modification] 1052684001118 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684001119 ATP binding site [chemical binding]; other site 1052684001120 Mg2+ binding site [ion binding]; other site 1052684001121 G-X-G motif; other site 1052684001122 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 1052684001123 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052684001124 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1052684001125 putative active site [active] 1052684001126 catalytic triad [active] 1052684001127 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 1052684001128 PA/protease or protease-like domain interface [polypeptide binding]; other site 1052684001129 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 1052684001130 S-layer homology domain; Region: SLH; pfam00395 1052684001131 S-layer homology domain; Region: SLH; pfam00395 1052684001132 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1052684001133 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1052684001134 DHHA2 domain; Region: DHHA2; pfam02833 1052684001135 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1052684001136 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1052684001137 substrate binding pocket [chemical binding]; other site 1052684001138 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052684001139 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684001140 MarR family; Region: MarR; pfam01047 1052684001141 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1052684001142 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 1052684001143 active site 1052684001144 DNA binding site [nucleotide binding] 1052684001145 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 1052684001146 DNA binding site [nucleotide binding] 1052684001147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684001148 Coenzyme A binding pocket [chemical binding]; other site 1052684001149 Predicted membrane protein [Function unknown]; Region: COG2322 1052684001150 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684001151 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684001152 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684001153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001154 dimer interface [polypeptide binding]; other site 1052684001155 conserved gate region; other site 1052684001156 putative PBP binding loops; other site 1052684001157 ABC-ATPase subunit interface; other site 1052684001158 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684001159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001160 dimer interface [polypeptide binding]; other site 1052684001161 conserved gate region; other site 1052684001162 putative PBP binding loops; other site 1052684001163 ABC-ATPase subunit interface; other site 1052684001164 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 1052684001165 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 1052684001166 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1052684001167 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1052684001168 putative active site cavity [active] 1052684001169 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1052684001170 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1052684001171 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1052684001172 putative active site [active] 1052684001173 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1052684001174 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052684001175 nucleotide binding site [chemical binding]; other site 1052684001176 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1052684001177 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052684001178 PAS domain; Region: PAS_9; pfam13426 1052684001179 putative active site [active] 1052684001180 heme pocket [chemical binding]; other site 1052684001181 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1052684001182 Histidine kinase; Region: HisKA_3; pfam07730 1052684001183 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684001184 ATP binding site [chemical binding]; other site 1052684001185 Mg2+ binding site [ion binding]; other site 1052684001186 G-X-G motif; other site 1052684001187 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052684001188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684001189 active site 1052684001190 phosphorylation site [posttranslational modification] 1052684001191 intermolecular recognition site; other site 1052684001192 dimerization interface [polypeptide binding]; other site 1052684001193 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052684001194 DNA binding residues [nucleotide binding] 1052684001195 dimerization interface [polypeptide binding]; other site 1052684001196 GAF domain; Region: GAF; pfam01590 1052684001197 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1052684001198 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1052684001199 ligand binding site [chemical binding]; other site 1052684001200 flexible hinge region; other site 1052684001201 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1052684001202 putative switch regulator; other site 1052684001203 non-specific DNA interactions [nucleotide binding]; other site 1052684001204 DNA binding site [nucleotide binding] 1052684001205 sequence specific DNA binding site [nucleotide binding]; other site 1052684001206 putative cAMP binding site [chemical binding]; other site 1052684001207 A domain family that is part of the cupin metalloenzyme superfamily; Region: JmjC; smart00558 1052684001208 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684001209 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684001210 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1052684001211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001212 conserved gate region; other site 1052684001213 dimer interface [polypeptide binding]; other site 1052684001214 putative PBP binding loops; other site 1052684001215 ABC-ATPase subunit interface; other site 1052684001216 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684001217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001218 dimer interface [polypeptide binding]; other site 1052684001219 conserved gate region; other site 1052684001220 putative PBP binding loops; other site 1052684001221 ABC-ATPase subunit interface; other site 1052684001222 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684001223 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684001224 dimerization interface [polypeptide binding]; other site 1052684001225 Histidine kinase; Region: His_kinase; pfam06580 1052684001226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684001227 ATP binding site [chemical binding]; other site 1052684001228 Mg2+ binding site [ion binding]; other site 1052684001229 G-X-G motif; other site 1052684001230 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684001231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684001232 active site 1052684001233 phosphorylation site [posttranslational modification] 1052684001234 intermolecular recognition site; other site 1052684001235 dimerization interface [polypeptide binding]; other site 1052684001236 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684001237 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684001238 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684001239 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684001240 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684001241 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684001242 dimerization interface [polypeptide binding]; other site 1052684001243 aromatic acid decarboxylase; Validated; Region: PRK05920 1052684001244 Flavoprotein; Region: Flavoprotein; pfam02441 1052684001245 UbiD family decarboxylase; Region: TIGR00148 1052684001246 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1052684001247 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052684001248 Beta-lactamase; Region: Beta-lactamase; pfam00144 1052684001249 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1052684001250 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1052684001251 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1052684001252 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1052684001253 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1052684001254 ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879 1052684001255 L-serine binding site [chemical binding]; other site 1052684001256 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1052684001257 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052684001258 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052684001259 Walker A/P-loop; other site 1052684001260 ATP binding site [chemical binding]; other site 1052684001261 Q-loop/lid; other site 1052684001262 ABC transporter signature motif; other site 1052684001263 Walker B; other site 1052684001264 D-loop; other site 1052684001265 H-loop/switch region; other site 1052684001266 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052684001267 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1052684001268 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052684001269 Walker A/P-loop; other site 1052684001270 ATP binding site [chemical binding]; other site 1052684001271 Q-loop/lid; other site 1052684001272 ABC transporter signature motif; other site 1052684001273 Walker B; other site 1052684001274 D-loop; other site 1052684001275 H-loop/switch region; other site 1052684001276 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052684001277 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052684001278 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001279 dimer interface [polypeptide binding]; other site 1052684001280 conserved gate region; other site 1052684001281 putative PBP binding loops; other site 1052684001282 ABC-ATPase subunit interface; other site 1052684001283 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052684001284 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001285 dimer interface [polypeptide binding]; other site 1052684001286 conserved gate region; other site 1052684001287 putative PBP binding loops; other site 1052684001288 ABC-ATPase subunit interface; other site 1052684001289 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 1052684001290 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1052684001291 peptide binding site [polypeptide binding]; other site 1052684001292 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684001293 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684001294 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684001295 dimerization interface [polypeptide binding]; other site 1052684001296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001297 dimer interface [polypeptide binding]; other site 1052684001298 conserved gate region; other site 1052684001299 putative PBP binding loops; other site 1052684001300 ABC-ATPase subunit interface; other site 1052684001301 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052684001302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001303 dimer interface [polypeptide binding]; other site 1052684001304 conserved gate region; other site 1052684001305 putative PBP binding loops; other site 1052684001306 ABC-ATPase subunit interface; other site 1052684001307 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052684001308 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052684001309 substrate binding pocket [chemical binding]; other site 1052684001310 membrane-bound complex binding site; other site 1052684001311 hinge residues; other site 1052684001312 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052684001313 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052684001314 Walker A/P-loop; other site 1052684001315 ATP binding site [chemical binding]; other site 1052684001316 Q-loop/lid; other site 1052684001317 ABC transporter signature motif; other site 1052684001318 Walker B; other site 1052684001319 D-loop; other site 1052684001320 H-loop/switch region; other site 1052684001321 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 1052684001322 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052684001323 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052684001324 metal binding site [ion binding]; metal-binding site 1052684001325 active site 1052684001326 I-site; other site 1052684001327 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166 1052684001328 active site 1052684001329 catalytic site [active] 1052684001330 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 1052684001331 Collagen binding domain; Region: Collagen_bind; pfam05737 1052684001332 Collagen binding domain; Region: Collagen_bind; pfam05737 1052684001333 Collagen binding domain; Region: Collagen_bind; pfam05737 1052684001334 Collagen binding domain; Region: Collagen_bind; pfam05737 1052684001335 Cna protein B-type domain; Region: Cna_B; pfam05738 1052684001336 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 1052684001337 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1052684001338 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1052684001339 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684001340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684001341 Protein of unknown function (DUF445); Region: DUF445; pfam04286 1052684001342 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1052684001343 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1052684001344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684001345 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684001346 dimer interface [polypeptide binding]; other site 1052684001347 phosphorylation site [posttranslational modification] 1052684001348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684001349 ATP binding site [chemical binding]; other site 1052684001350 Mg2+ binding site [ion binding]; other site 1052684001351 G-X-G motif; other site 1052684001352 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684001353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684001354 active site 1052684001355 phosphorylation site [posttranslational modification] 1052684001356 intermolecular recognition site; other site 1052684001357 dimerization interface [polypeptide binding]; other site 1052684001358 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052684001359 Histidine kinase; Region: His_kinase; pfam06580 1052684001360 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684001361 ATP binding site [chemical binding]; other site 1052684001362 Mg2+ binding site [ion binding]; other site 1052684001363 G-X-G motif; other site 1052684001364 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1052684001365 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684001366 active site 1052684001367 phosphorylation site [posttranslational modification] 1052684001368 intermolecular recognition site; other site 1052684001369 dimerization interface [polypeptide binding]; other site 1052684001370 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 1052684001371 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1052684001372 dimer interface [polypeptide binding]; other site 1052684001373 FMN binding site [chemical binding]; other site 1052684001374 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684001375 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052684001376 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684001377 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1052684001378 active site 1052684001379 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1052684001380 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 1052684001381 CopC domain; Region: CopC; pfam04234 1052684001382 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1052684001383 YtkA-like; Region: YtkA; pfam13115 1052684001384 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052684001385 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052684001386 metal binding site [ion binding]; metal-binding site 1052684001387 active site 1052684001388 I-site; other site 1052684001389 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1052684001390 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052684001391 Zn2+ binding site [ion binding]; other site 1052684001392 Mg2+ binding site [ion binding]; other site 1052684001393 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 1052684001394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684001395 putative substrate translocation pore; other site 1052684001396 RNA polymerase sigma factor; Provisional; Region: PRK12543 1052684001397 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684001398 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684001399 DNA binding residues [nucleotide binding] 1052684001400 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 1052684001401 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 1052684001402 putative homodimer interface [polypeptide binding]; other site 1052684001403 putative homotetramer interface [polypeptide binding]; other site 1052684001404 allosteric switch controlling residues; other site 1052684001405 putative metal binding site [ion binding]; other site 1052684001406 putative homodimer-homodimer interface [polypeptide binding]; other site 1052684001407 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052684001408 metal-binding site [ion binding] 1052684001409 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052684001410 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052684001411 metal-binding site [ion binding] 1052684001412 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1052684001413 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052684001414 metal-binding site [ion binding] 1052684001415 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052684001416 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1052684001417 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1052684001418 dimer interface [polypeptide binding]; other site 1052684001419 FMN binding site [chemical binding]; other site 1052684001420 NADPH bind site [chemical binding]; other site 1052684001421 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1052684001422 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1052684001423 active site 1052684001424 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1052684001425 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1052684001426 Walker A/P-loop; other site 1052684001427 ATP binding site [chemical binding]; other site 1052684001428 Q-loop/lid; other site 1052684001429 ABC transporter signature motif; other site 1052684001430 Walker B; other site 1052684001431 D-loop; other site 1052684001432 H-loop/switch region; other site 1052684001433 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1052684001434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001435 dimer interface [polypeptide binding]; other site 1052684001436 conserved gate region; other site 1052684001437 putative PBP binding loops; other site 1052684001438 ABC-ATPase subunit interface; other site 1052684001439 Domain of unknown function DUF77; Region: DUF77; pfam01910 1052684001440 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1052684001441 NMT1/THI5 like; Region: NMT1; pfam09084 1052684001442 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1052684001443 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1052684001444 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1052684001445 active site 1052684001446 metal binding site [ion binding]; metal-binding site 1052684001447 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052684001448 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1052684001449 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052684001450 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052684001451 Ca binding site [ion binding]; other site 1052684001452 active site 1052684001453 catalytic site [active] 1052684001454 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1052684001455 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 1052684001456 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1052684001457 NodB motif; other site 1052684001458 active site 1052684001459 catalytic site [active] 1052684001460 Cd binding site [ion binding]; other site 1052684001461 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1052684001462 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1052684001463 Walker A/P-loop; other site 1052684001464 ATP binding site [chemical binding]; other site 1052684001465 Q-loop/lid; other site 1052684001466 ABC transporter signature motif; other site 1052684001467 Walker B; other site 1052684001468 D-loop; other site 1052684001469 H-loop/switch region; other site 1052684001470 NIL domain; Region: NIL; pfam09383 1052684001471 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001472 ABC-ATPase subunit interface; other site 1052684001473 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052684001474 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052684001475 active site 1052684001476 catalytic tetrad [active] 1052684001477 S-layer homology domain; Region: SLH; pfam00395 1052684001478 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1052684001479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684001480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684001481 dimer interface [polypeptide binding]; other site 1052684001482 phosphorylation site [posttranslational modification] 1052684001483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684001484 ATP binding site [chemical binding]; other site 1052684001485 Mg2+ binding site [ion binding]; other site 1052684001486 G-X-G motif; other site 1052684001487 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1052684001488 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684001489 active site 1052684001490 phosphorylation site [posttranslational modification] 1052684001491 intermolecular recognition site; other site 1052684001492 dimerization interface [polypeptide binding]; other site 1052684001493 Histidine kinase; Region: His_kinase; pfam06580 1052684001494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684001495 ATP binding site [chemical binding]; other site 1052684001496 Mg2+ binding site [ion binding]; other site 1052684001497 G-X-G motif; other site 1052684001498 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 1052684001499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684001500 active site 1052684001501 phosphorylation site [posttranslational modification] 1052684001502 intermolecular recognition site; other site 1052684001503 dimerization interface [polypeptide binding]; other site 1052684001504 DNA binding site [nucleotide binding] 1052684001505 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1052684001506 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1052684001507 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1052684001508 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1052684001509 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1052684001510 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 1052684001511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684001512 Walker A motif; other site 1052684001513 ATP binding site [chemical binding]; other site 1052684001514 Walker B motif; other site 1052684001515 arginine finger; other site 1052684001516 Transcriptional antiterminator [Transcription]; Region: COG3933 1052684001517 PRD domain; Region: PRD; pfam00874 1052684001518 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1052684001519 active pocket/dimerization site; other site 1052684001520 active site 1052684001521 phosphorylation site [posttranslational modification] 1052684001522 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1052684001523 active pocket/dimerization site; other site 1052684001524 active site 1052684001525 phosphorylation site [posttranslational modification] 1052684001526 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1052684001527 active site 1052684001528 phosphorylation site [posttranslational modification] 1052684001529 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1052684001530 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 1052684001531 maltodextrin glucosidase; Provisional; Region: PRK10785 1052684001532 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1052684001533 homodimer interface [polypeptide binding]; other site 1052684001534 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1052684001535 active site 1052684001536 homodimer interface [polypeptide binding]; other site 1052684001537 catalytic site [active] 1052684001538 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1052684001539 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684001540 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684001541 active site 1052684001542 phosphorylation site [posttranslational modification] 1052684001543 intermolecular recognition site; other site 1052684001544 dimerization interface [polypeptide binding]; other site 1052684001545 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684001546 DNA binding site [nucleotide binding] 1052684001547 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684001548 HAMP domain; Region: HAMP; pfam00672 1052684001549 dimerization interface [polypeptide binding]; other site 1052684001550 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684001551 dimer interface [polypeptide binding]; other site 1052684001552 phosphorylation site [posttranslational modification] 1052684001553 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684001554 ATP binding site [chemical binding]; other site 1052684001555 Mg2+ binding site [ion binding]; other site 1052684001556 G-X-G motif; other site 1052684001557 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052684001558 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1052684001559 Walker A/P-loop; other site 1052684001560 ATP binding site [chemical binding]; other site 1052684001561 Q-loop/lid; other site 1052684001562 ABC transporter signature motif; other site 1052684001563 Walker B; other site 1052684001564 D-loop; other site 1052684001565 H-loop/switch region; other site 1052684001566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1052684001567 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052684001568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1052684001569 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052684001570 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1052684001571 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1052684001572 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052684001573 NAD binding site [chemical binding]; other site 1052684001574 dimer interface [polypeptide binding]; other site 1052684001575 substrate binding site [chemical binding]; other site 1052684001576 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1052684001577 DNA binding residues [nucleotide binding] 1052684001578 Protein kinase domain; Region: Pkinase; pfam00069 1052684001579 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1052684001580 active site 1052684001581 ATP binding site [chemical binding]; other site 1052684001582 substrate binding site [chemical binding]; other site 1052684001583 activation loop (A-loop); other site 1052684001584 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1052684001585 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1052684001586 N- and C-terminal domain interface [polypeptide binding]; other site 1052684001587 active site 1052684001588 catalytic site [active] 1052684001589 metal binding site [ion binding]; metal-binding site 1052684001590 carbohydrate binding site [chemical binding]; other site 1052684001591 ATP binding site [chemical binding]; other site 1052684001592 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1052684001593 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684001594 DNA-binding site [nucleotide binding]; DNA binding site 1052684001595 FCD domain; Region: FCD; pfam07729 1052684001596 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1052684001597 active site 1052684001598 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 1052684001599 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 1052684001600 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1052684001601 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052684001602 dimer interface [polypeptide binding]; other site 1052684001603 FMN binding site [chemical binding]; other site 1052684001604 Predicted integral membrane protein [Function unknown]; Region: COG0392 1052684001605 Uncharacterized conserved protein [Function unknown]; Region: COG2898 1052684001606 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1052684001607 Predicted ATPase [General function prediction only]; Region: COG3910 1052684001608 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684001609 Walker A/P-loop; other site 1052684001610 ATP binding site [chemical binding]; other site 1052684001611 Q-loop/lid; other site 1052684001612 ABC transporter signature motif; other site 1052684001613 Walker B; other site 1052684001614 D-loop; other site 1052684001615 H-loop/switch region; other site 1052684001616 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1052684001617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684001618 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684001619 putative substrate translocation pore; other site 1052684001620 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1052684001621 Predicted transcriptional regulator [Transcription]; Region: COG4189 1052684001622 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684001623 putative DNA binding site [nucleotide binding]; other site 1052684001624 dimerization interface [polypeptide binding]; other site 1052684001625 putative Zn2+ binding site [ion binding]; other site 1052684001626 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684001627 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684001628 Coenzyme A binding pocket [chemical binding]; other site 1052684001629 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052684001630 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1052684001631 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052684001632 NAD binding site [chemical binding]; other site 1052684001633 putative active site [active] 1052684001634 substrate binding site [chemical binding]; other site 1052684001635 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1052684001636 putative carbohydrate kinase; Provisional; Region: PRK10565 1052684001637 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1052684001638 putative substrate binding site [chemical binding]; other site 1052684001639 putative ATP binding site [chemical binding]; other site 1052684001640 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 1052684001641 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684001642 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1052684001643 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684001644 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684001645 dimer interface [polypeptide binding]; other site 1052684001646 putative CheW interface [polypeptide binding]; other site 1052684001647 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1052684001648 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1052684001649 dimer interface [polypeptide binding]; other site 1052684001650 putative radical transfer pathway; other site 1052684001651 diiron center [ion binding]; other site 1052684001652 tyrosyl radical; other site 1052684001653 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 1052684001654 ATP cone domain; Region: ATP-cone; pfam03477 1052684001655 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 1052684001656 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 1052684001657 Domain of unknown function DUF77; Region: DUF77; pfam01910 1052684001658 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052684001659 DNA binding site [nucleotide binding] 1052684001660 active site 1052684001661 Int/Topo IB signature motif; other site 1052684001662 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1052684001663 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684001664 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052684001665 short chain dehydrogenase; Provisional; Region: PRK06500 1052684001666 classical (c) SDRs; Region: SDR_c; cd05233 1052684001667 NAD(P) binding site [chemical binding]; other site 1052684001668 active site 1052684001669 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684001670 motif II; other site 1052684001671 Spore germination protein; Region: Spore_permease; cl17796 1052684001672 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052684001673 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052684001674 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052684001675 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1052684001676 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684001677 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684001678 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1052684001679 classical (c) SDRs; Region: SDR_c; cd05233 1052684001680 NAD(P) binding site [chemical binding]; other site 1052684001681 active site 1052684001682 fructoselysine 3-epimerase; Provisional; Region: PRK09856 1052684001683 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1052684001684 hypothetical protein; Provisional; Region: PHA02764 1052684001685 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1052684001686 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1052684001687 putative active site [active] 1052684001688 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1052684001689 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1052684001690 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052684001691 substrate binding site [chemical binding]; other site 1052684001692 ATP binding site [chemical binding]; other site 1052684001693 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1052684001694 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684001695 DNA-binding site [nucleotide binding]; DNA binding site 1052684001696 UTRA domain; Region: UTRA; pfam07702 1052684001697 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052684001698 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1052684001699 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1052684001700 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052684001701 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052684001702 Dienelactone hydrolase family; Region: DLH; pfam01738 1052684001703 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684001704 dimerization interface [polypeptide binding]; other site 1052684001705 putative DNA binding site [nucleotide binding]; other site 1052684001706 putative Zn2+ binding site [ion binding]; other site 1052684001707 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1052684001708 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 1052684001709 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052684001710 homodimer interface [polypeptide binding]; other site 1052684001711 substrate-cofactor binding pocket; other site 1052684001712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684001713 catalytic residue [active] 1052684001714 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1052684001715 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684001716 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052684001717 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1052684001718 active site residue [active] 1052684001719 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1052684001720 dimer interface [polypeptide binding]; other site 1052684001721 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052684001722 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1052684001723 MarR family; Region: MarR_2; pfam12802 1052684001724 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 1052684001725 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1052684001726 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684001727 dimerization interface [polypeptide binding]; other site 1052684001728 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1052684001729 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052684001730 Zn2+ binding site [ion binding]; other site 1052684001731 Mg2+ binding site [ion binding]; other site 1052684001732 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1052684001733 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684001734 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684001735 dimer interface [polypeptide binding]; other site 1052684001736 phosphorylation site [posttranslational modification] 1052684001737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684001738 ATP binding site [chemical binding]; other site 1052684001739 Mg2+ binding site [ion binding]; other site 1052684001740 G-X-G motif; other site 1052684001741 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1052684001742 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1052684001743 NAD binding site [chemical binding]; other site 1052684001744 active site 1052684001745 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1052684001746 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1052684001747 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684001748 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684001749 DNA binding residues [nucleotide binding] 1052684001750 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1052684001751 homotrimer interaction site [polypeptide binding]; other site 1052684001752 putative active site [active] 1052684001753 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 1052684001754 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1052684001755 active site 1052684001756 homodimer interface [polypeptide binding]; other site 1052684001757 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1052684001758 Sodium Bile acid symporter family; Region: SBF; cl17470 1052684001759 Sodium Bile acid symporter family; Region: SBF; cl17470 1052684001760 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1052684001761 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 1052684001762 putative active site [active] 1052684001763 putative FMN binding site [chemical binding]; other site 1052684001764 putative substrate binding site [chemical binding]; other site 1052684001765 putative catalytic residue [active] 1052684001766 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052684001767 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052684001768 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684001769 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684001770 active site 1052684001771 phosphorylation site [posttranslational modification] 1052684001772 intermolecular recognition site; other site 1052684001773 dimerization interface [polypeptide binding]; other site 1052684001774 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684001775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684001776 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684001777 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052684001778 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684001779 dimerization interface [polypeptide binding]; other site 1052684001780 Histidine kinase; Region: His_kinase; pfam06580 1052684001781 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684001782 ATP binding site [chemical binding]; other site 1052684001783 Mg2+ binding site [ion binding]; other site 1052684001784 G-X-G motif; other site 1052684001785 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684001786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001787 dimer interface [polypeptide binding]; other site 1052684001788 conserved gate region; other site 1052684001789 putative PBP binding loops; other site 1052684001790 ABC-ATPase subunit interface; other site 1052684001791 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684001792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001793 dimer interface [polypeptide binding]; other site 1052684001794 conserved gate region; other site 1052684001795 putative PBP binding loops; other site 1052684001796 ABC-ATPase subunit interface; other site 1052684001797 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684001798 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684001799 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1052684001800 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1052684001801 folate binding site [chemical binding]; other site 1052684001802 NADP+ binding site [chemical binding]; other site 1052684001803 Predicted transcriptional regulator [Transcription]; Region: COG2378 1052684001804 HTH domain; Region: HTH_11; pfam08279 1052684001805 WYL domain; Region: WYL; pfam13280 1052684001806 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1052684001807 SNF2 Helicase protein; Region: DUF3670; pfam12419 1052684001808 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052684001809 ATP binding site [chemical binding]; other site 1052684001810 putative Mg++ binding site [ion binding]; other site 1052684001811 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684001812 nucleotide binding region [chemical binding]; other site 1052684001813 ATP-binding site [chemical binding]; other site 1052684001814 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1052684001815 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1052684001816 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 1052684001817 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1052684001818 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1052684001819 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052684001820 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684001821 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052684001822 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684001823 putative substrate translocation pore; other site 1052684001824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684001825 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684001826 MarR family; Region: MarR_2; pfam12802 1052684001827 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684001828 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684001829 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052684001830 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684001831 putative substrate translocation pore; other site 1052684001832 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 1052684001833 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684001834 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684001835 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1052684001836 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1052684001837 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1052684001838 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1052684001839 active site 1052684001840 dimer interface [polypeptide binding]; other site 1052684001841 motif 1; other site 1052684001842 motif 2; other site 1052684001843 motif 3; other site 1052684001844 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1052684001845 anticodon binding site; other site 1052684001846 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052684001847 synthetase active site [active] 1052684001848 NTP binding site [chemical binding]; other site 1052684001849 metal binding site [ion binding]; metal-binding site 1052684001850 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1052684001851 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052684001852 classical (c) SDRs; Region: SDR_c; cd05233 1052684001853 NAD(P) binding site [chemical binding]; other site 1052684001854 active site 1052684001855 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1052684001856 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1052684001857 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684001858 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684001859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684001860 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684001861 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1052684001862 Melibiase; Region: Melibiase; pfam02065 1052684001863 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052684001864 Histidine kinase; Region: His_kinase; pfam06580 1052684001865 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684001866 ATP binding site [chemical binding]; other site 1052684001867 Mg2+ binding site [ion binding]; other site 1052684001868 G-X-G motif; other site 1052684001869 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684001870 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684001871 active site 1052684001872 phosphorylation site [posttranslational modification] 1052684001873 intermolecular recognition site; other site 1052684001874 dimerization interface [polypeptide binding]; other site 1052684001875 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684001876 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684001877 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684001878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001879 dimer interface [polypeptide binding]; other site 1052684001880 conserved gate region; other site 1052684001881 putative PBP binding loops; other site 1052684001882 ABC-ATPase subunit interface; other site 1052684001883 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684001884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684001885 dimer interface [polypeptide binding]; other site 1052684001886 conserved gate region; other site 1052684001887 ABC-ATPase subunit interface; other site 1052684001888 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684001889 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684001890 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1052684001891 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 1052684001892 putative metal binding site [ion binding]; other site 1052684001893 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1052684001894 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684001895 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684001896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052684001897 Coenzyme A binding pocket [chemical binding]; other site 1052684001898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684001899 NAD(P) binding site [chemical binding]; other site 1052684001900 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1052684001901 active site 1052684001902 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1052684001903 Part of AAA domain; Region: AAA_19; pfam13245 1052684001904 Family description; Region: UvrD_C_2; pfam13538 1052684001905 Cold-inducible protein YdjO; Region: YdjO; pfam14169 1052684001906 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1052684001907 Predicted transcriptional regulators [Transcription]; Region: COG1378 1052684001908 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1052684001909 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1052684001910 C-terminal domain interface [polypeptide binding]; other site 1052684001911 sugar binding site [chemical binding]; other site 1052684001912 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1052684001913 nudix motif; other site 1052684001914 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1052684001915 catalytic core [active] 1052684001916 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1052684001917 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1052684001918 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1052684001919 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1052684001920 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 1052684001921 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684001922 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684001923 DNA binding residues [nucleotide binding] 1052684001924 Predicted membrane protein [Function unknown]; Region: COG4818 1052684001925 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1052684001926 MOSC domain; Region: MOSC; pfam03473 1052684001927 3-alpha domain; Region: 3-alpha; pfam03475 1052684001928 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1052684001929 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1052684001930 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052684001931 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052684001932 Beta-lactamase; Region: Beta-lactamase; pfam00144 1052684001933 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1052684001934 active site 1052684001935 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052684001936 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052684001937 Uncharacterized conserved protein [Function unknown]; Region: COG2461 1052684001938 Family of unknown function (DUF438); Region: DUF438; pfam04282 1052684001939 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1052684001940 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 1052684001941 Predicted transcriptional regulators [Transcription]; Region: COG1725 1052684001942 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684001943 DNA-binding site [nucleotide binding]; DNA binding site 1052684001944 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052684001945 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052684001946 Walker A/P-loop; other site 1052684001947 ATP binding site [chemical binding]; other site 1052684001948 Q-loop/lid; other site 1052684001949 ABC transporter signature motif; other site 1052684001950 Walker B; other site 1052684001951 D-loop; other site 1052684001952 H-loop/switch region; other site 1052684001953 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1052684001954 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684001955 Walker A/P-loop; other site 1052684001956 ATP binding site [chemical binding]; other site 1052684001957 Q-loop/lid; other site 1052684001958 ABC transporter signature motif; other site 1052684001959 Walker B; other site 1052684001960 D-loop; other site 1052684001961 H-loop/switch region; other site 1052684001962 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1052684001963 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1052684001964 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684001965 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684001966 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1052684001967 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1052684001968 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1052684001969 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684001970 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1052684001971 FeS/SAM binding site; other site 1052684001972 SnoaL-like domain; Region: SnoaL_3; pfam13474 1052684001973 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 1052684001974 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684001975 Helix-turn-helix domain; Region: HTH_18; pfam12833 1052684001976 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684001977 recombination factor protein RarA; Reviewed; Region: PRK13342 1052684001978 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684001979 Walker A motif; other site 1052684001980 ATP binding site [chemical binding]; other site 1052684001981 Walker B motif; other site 1052684001982 arginine finger; other site 1052684001983 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1052684001984 Protein of unknown function (DUF419); Region: DUF419; pfam04237 1052684001985 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 1052684001986 putative active site [active] 1052684001987 putative catalytic site [active] 1052684001988 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1052684001989 catalytic residue [active] 1052684001990 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1052684001991 Protein of unknown function, DUF600; Region: DUF600; cl04640 1052684001992 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684001993 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684001994 intersubunit interface [polypeptide binding]; other site 1052684001995 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684001996 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684001997 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684001998 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684001999 intersubunit interface [polypeptide binding]; other site 1052684002000 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1052684002001 Sodium Bile acid symporter family; Region: SBF; cl17470 1052684002002 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684002003 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684002004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684002005 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1052684002006 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1052684002007 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 1052684002008 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1052684002009 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 1052684002010 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1052684002011 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1052684002012 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1052684002013 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1052684002014 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684002015 dimerization interface [polypeptide binding]; other site 1052684002016 putative DNA binding site [nucleotide binding]; other site 1052684002017 putative Zn2+ binding site [ion binding]; other site 1052684002018 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052684002019 active site residue [active] 1052684002020 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684002021 MarR family; Region: MarR_2; pfam12802 1052684002022 OsmC-like protein; Region: OsmC; pfam02566 1052684002023 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 1052684002024 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052684002025 E3 interaction surface; other site 1052684002026 lipoyl attachment site [posttranslational modification]; other site 1052684002027 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 1052684002028 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1052684002029 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684002030 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052684002031 maltose O-acetyltransferase; Provisional; Region: PRK10092 1052684002032 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1052684002033 active site 1052684002034 substrate binding site [chemical binding]; other site 1052684002035 trimer interface [polypeptide binding]; other site 1052684002036 CoA binding site [chemical binding]; other site 1052684002037 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1052684002038 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684002039 non-specific DNA binding site [nucleotide binding]; other site 1052684002040 salt bridge; other site 1052684002041 sequence-specific DNA binding site [nucleotide binding]; other site 1052684002042 Cupin domain; Region: Cupin_2; pfam07883 1052684002043 LysE type translocator; Region: LysE; cl00565 1052684002044 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1052684002045 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1052684002046 Ca binding site [ion binding]; other site 1052684002047 active site 1052684002048 catalytic site [active] 1052684002049 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052684002050 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 1052684002051 active site turn [active] 1052684002052 phosphorylation site [posttranslational modification] 1052684002053 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684002054 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052684002055 HPr interaction site; other site 1052684002056 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052684002057 active site 1052684002058 phosphorylation site [posttranslational modification] 1052684002059 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684002060 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 1052684002061 DNA-binding site [nucleotide binding]; DNA binding site 1052684002062 UTRA domain; Region: UTRA; pfam07702 1052684002063 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052684002064 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052684002065 Spore germination protein; Region: Spore_permease; pfam03845 1052684002066 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052684002067 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1052684002068 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684002069 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1052684002070 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1052684002071 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052684002072 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1052684002073 iron-sulfur cluster [ion binding]; other site 1052684002074 [2Fe-2S] cluster binding site [ion binding]; other site 1052684002075 BclB C-terminal domain; Region: exospore_TM; TIGR03721 1052684002076 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1052684002077 sugar binding site [chemical binding]; other site 1052684002078 S-layer homology domain; Region: SLH; pfam00395 1052684002079 S-layer homology domain; Region: SLH; pfam00395 1052684002080 S-layer homology domain; Region: SLH; pfam00395 1052684002081 Phage Tail Collar Domain; Region: Collar; pfam07484 1052684002082 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052684002083 Spore germination protein; Region: Spore_permease; pfam03845 1052684002084 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052684002085 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052684002086 Predicted transcriptional regulators [Transcription]; Region: COG1695 1052684002087 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1052684002088 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1052684002089 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1052684002090 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684002091 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052684002092 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1052684002093 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684002094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684002095 active site 1052684002096 phosphorylation site [posttranslational modification] 1052684002097 intermolecular recognition site; other site 1052684002098 dimerization interface [polypeptide binding]; other site 1052684002099 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684002100 DNA binding site [nucleotide binding] 1052684002101 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684002102 dimerization interface [polypeptide binding]; other site 1052684002103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684002104 dimer interface [polypeptide binding]; other site 1052684002105 phosphorylation site [posttranslational modification] 1052684002106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684002107 ATP binding site [chemical binding]; other site 1052684002108 Mg2+ binding site [ion binding]; other site 1052684002109 G-X-G motif; other site 1052684002110 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1052684002111 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1052684002112 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052684002113 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1052684002114 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1052684002115 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052684002116 Predicted flavoprotein [General function prediction only]; Region: COG0431 1052684002117 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 1052684002118 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1052684002119 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1052684002120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1052684002121 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052684002122 dimer interface [polypeptide binding]; other site 1052684002123 FMN binding site [chemical binding]; other site 1052684002124 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052684002125 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052684002126 Zn binding site [ion binding]; other site 1052684002127 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052684002128 Zn binding site [ion binding]; other site 1052684002129 SWIM zinc finger; Region: SWIM; pfam04434 1052684002130 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1052684002131 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1052684002132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052684002133 ATP binding site [chemical binding]; other site 1052684002134 putative Mg++ binding site [ion binding]; other site 1052684002135 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684002136 nucleotide binding region [chemical binding]; other site 1052684002137 ATP-binding site [chemical binding]; other site 1052684002138 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 1052684002139 Phosphotransferase enzyme family; Region: APH; pfam01636 1052684002140 putative active site [active] 1052684002141 putative substrate binding site [chemical binding]; other site 1052684002142 ATP binding site [chemical binding]; other site 1052684002143 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 1052684002144 active site 1052684002145 putative substrate binding region [chemical binding]; other site 1052684002146 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684002147 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684002148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684002149 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1052684002150 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1052684002151 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1052684002152 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052684002153 HAMP domain; Region: HAMP; pfam00672 1052684002154 Histidine kinase; Region: His_kinase; pfam06580 1052684002155 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684002156 ATP binding site [chemical binding]; other site 1052684002157 Mg2+ binding site [ion binding]; other site 1052684002158 G-X-G motif; other site 1052684002159 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684002160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684002161 active site 1052684002162 phosphorylation site [posttranslational modification] 1052684002163 intermolecular recognition site; other site 1052684002164 dimerization interface [polypeptide binding]; other site 1052684002165 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684002166 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684002167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684002168 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684002169 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684002170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684002171 dimer interface [polypeptide binding]; other site 1052684002172 conserved gate region; other site 1052684002173 putative PBP binding loops; other site 1052684002174 ABC-ATPase subunit interface; other site 1052684002175 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684002176 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684002177 dimer interface [polypeptide binding]; other site 1052684002178 conserved gate region; other site 1052684002179 putative PBP binding loops; other site 1052684002180 ABC-ATPase subunit interface; other site 1052684002181 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1052684002182 calcium mediated ligand binding site; other site 1052684002183 intermolecular salt bridges; other site 1052684002184 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1052684002185 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052684002186 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1052684002187 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052684002188 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 1052684002189 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052684002190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684002191 DNA-binding site [nucleotide binding]; DNA binding site 1052684002192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684002193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684002194 homodimer interface [polypeptide binding]; other site 1052684002195 catalytic residue [active] 1052684002196 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1052684002197 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684002198 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684002199 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052684002200 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 1052684002201 DNA binding residues [nucleotide binding] 1052684002202 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052684002203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684002204 putative substrate translocation pore; other site 1052684002205 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1052684002206 Ligand Binding Site [chemical binding]; other site 1052684002207 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 1052684002208 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1052684002209 NAD(P) binding site [chemical binding]; other site 1052684002210 catalytic residues [active] 1052684002211 short chain dehydrogenase; Provisional; Region: PRK06523 1052684002212 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684002213 NAD(P) binding site [chemical binding]; other site 1052684002214 active site 1052684002215 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 1052684002216 SnoaL-like domain; Region: SnoaL_2; pfam12680 1052684002217 Predicted transcriptional regulator [Transcription]; Region: COG2378 1052684002218 HTH domain; Region: HTH_11; pfam08279 1052684002219 WYL domain; Region: WYL; pfam13280 1052684002220 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1052684002221 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052684002222 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1052684002223 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 1052684002224 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1052684002225 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1052684002226 DNA binding residues [nucleotide binding] 1052684002227 putative dimer interface [polypeptide binding]; other site 1052684002228 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1052684002229 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052684002230 DNA binding residues [nucleotide binding] 1052684002231 dimer interface [polypeptide binding]; other site 1052684002232 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1052684002233 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1052684002234 GAF domain; Region: GAF_2; pfam13185 1052684002235 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052684002236 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052684002237 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1052684002238 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1052684002239 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1052684002240 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1052684002241 Walker A/P-loop; other site 1052684002242 ATP binding site [chemical binding]; other site 1052684002243 Q-loop/lid; other site 1052684002244 ABC transporter signature motif; other site 1052684002245 Walker B; other site 1052684002246 D-loop; other site 1052684002247 H-loop/switch region; other site 1052684002248 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1052684002249 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1052684002250 Walker A/P-loop; other site 1052684002251 ATP binding site [chemical binding]; other site 1052684002252 Q-loop/lid; other site 1052684002253 ABC transporter signature motif; other site 1052684002254 Walker B; other site 1052684002255 D-loop; other site 1052684002256 H-loop/switch region; other site 1052684002257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684002258 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684002259 putative substrate translocation pore; other site 1052684002260 Levansucrase/Invertase; Region: Glyco_hydro_68; pfam02435 1052684002261 active site 1052684002262 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1052684002263 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052684002264 substrate binding [chemical binding]; other site 1052684002265 active site 1052684002266 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052684002267 MarR family; Region: MarR_2; cl17246 1052684002268 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684002269 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1052684002270 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052684002271 LysE type translocator; Region: LysE; cl00565 1052684002272 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1052684002273 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1052684002274 putative active site [active] 1052684002275 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1052684002276 dimer interface [polypeptide binding]; other site 1052684002277 active site 1052684002278 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052684002279 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1052684002280 substrate binding site [chemical binding]; other site 1052684002281 ATP binding site [chemical binding]; other site 1052684002282 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052684002283 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684002284 DNA-binding site [nucleotide binding]; DNA binding site 1052684002285 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1052684002286 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1052684002287 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052684002288 active site 1052684002289 Predicted membrane protein [Function unknown]; Region: COG1288 1052684002290 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1052684002291 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1052684002292 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052684002293 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1052684002294 HI0933-like protein; Region: HI0933_like; pfam03486 1052684002295 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052684002296 PAS fold; Region: PAS_4; pfam08448 1052684002297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684002298 dimer interface [polypeptide binding]; other site 1052684002299 phosphorylation site [posttranslational modification] 1052684002300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684002301 ATP binding site [chemical binding]; other site 1052684002302 Mg2+ binding site [ion binding]; other site 1052684002303 G-X-G motif; other site 1052684002304 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 1052684002305 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1052684002306 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1052684002307 homodimer interface [polypeptide binding]; other site 1052684002308 NAD binding pocket [chemical binding]; other site 1052684002309 ATP binding pocket [chemical binding]; other site 1052684002310 Mg binding site [ion binding]; other site 1052684002311 active-site loop [active] 1052684002312 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052684002313 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1052684002314 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1052684002315 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052684002316 minor groove reading motif; other site 1052684002317 helix-hairpin-helix signature motif; other site 1052684002318 substrate binding pocket [chemical binding]; other site 1052684002319 active site 1052684002320 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1052684002321 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1052684002322 DNA binding and oxoG recognition site [nucleotide binding] 1052684002323 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052684002324 Spore germination protein; Region: Spore_permease; cl17796 1052684002325 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052684002326 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1052684002327 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684002328 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684002329 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684002330 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684002331 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1052684002332 Melibiase; Region: Melibiase; pfam02065 1052684002333 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1052684002334 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052684002335 active site turn [active] 1052684002336 phosphorylation site [posttranslational modification] 1052684002337 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684002338 DinB family; Region: DinB; cl17821 1052684002339 DinB superfamily; Region: DinB_2; pfam12867 1052684002340 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1052684002341 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1052684002342 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1052684002343 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684002344 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684002345 Coenzyme A binding pocket [chemical binding]; other site 1052684002346 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052684002347 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052684002348 Catalytic site [active] 1052684002349 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1052684002350 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052684002351 active site 1052684002352 epoxyqueuosine reductase; Region: TIGR00276 1052684002353 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1052684002354 HEAT repeats; Region: HEAT_2; pfam13646 1052684002355 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1052684002356 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1052684002357 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1052684002358 DNA binding site [nucleotide binding] 1052684002359 active site 1052684002360 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1052684002361 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1052684002362 homodecamer interface [polypeptide binding]; other site 1052684002363 GTP cyclohydrolase I; Provisional; Region: PLN03044 1052684002364 active site 1052684002365 putative catalytic site residues [active] 1052684002366 zinc binding site [ion binding]; other site 1052684002367 GTP-CH-I/GFRP interaction surface; other site 1052684002368 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1052684002369 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 1052684002370 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1052684002371 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1052684002372 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1052684002373 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1052684002374 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1052684002375 nucleophilic elbow; other site 1052684002376 catalytic triad; other site 1052684002377 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1052684002378 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1052684002379 Bacterial transcriptional regulator; Region: IclR; pfam01614 1052684002380 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1052684002381 ThiC-associated domain; Region: ThiC-associated; pfam13667 1052684002382 ThiC family; Region: ThiC; pfam01964 1052684002383 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052684002384 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052684002385 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052684002386 aconitate hydratase; Validated; Region: PRK09277 1052684002387 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1052684002388 substrate binding site [chemical binding]; other site 1052684002389 ligand binding site [chemical binding]; other site 1052684002390 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1052684002391 substrate binding site [chemical binding]; other site 1052684002392 Putative amidase domain; Region: Amidase_6; pfam12671 1052684002393 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1052684002394 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1052684002395 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1052684002396 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 1052684002397 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1052684002398 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1052684002399 active site 1052684002400 dimerization interface [polypeptide binding]; other site 1052684002401 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684002402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684002403 dimerization interface [polypeptide binding]; other site 1052684002404 Histidine kinase; Region: His_kinase; pfam06580 1052684002405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684002406 ATP binding site [chemical binding]; other site 1052684002407 Mg2+ binding site [ion binding]; other site 1052684002408 G-X-G motif; other site 1052684002409 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1052684002410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684002411 active site 1052684002412 phosphorylation site [posttranslational modification] 1052684002413 intermolecular recognition site; other site 1052684002414 dimerization interface [polypeptide binding]; other site 1052684002415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684002416 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684002417 PBP superfamily domain; Region: PBP_like_2; cl17296 1052684002418 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684002419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684002420 dimer interface [polypeptide binding]; other site 1052684002421 conserved gate region; other site 1052684002422 putative PBP binding loops; other site 1052684002423 ABC-ATPase subunit interface; other site 1052684002424 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684002425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684002426 dimer interface [polypeptide binding]; other site 1052684002427 conserved gate region; other site 1052684002428 putative PBP binding loops; other site 1052684002429 ABC-ATPase subunit interface; other site 1052684002430 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052684002431 active site 1052684002432 catalytic triad [active] 1052684002433 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1052684002434 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1052684002435 active site 1052684002436 zinc binding site [ion binding]; other site 1052684002437 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 1052684002438 EamA-like transporter family; Region: EamA; pfam00892 1052684002439 EamA-like transporter family; Region: EamA; pfam00892 1052684002440 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 1052684002441 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052684002442 inhibitor-cofactor binding pocket; inhibition site 1052684002443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684002444 catalytic residue [active] 1052684002445 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1052684002446 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1052684002447 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 1052684002448 Walker A/P-loop; other site 1052684002449 ATP binding site [chemical binding]; other site 1052684002450 Q-loop/lid; other site 1052684002451 ABC transporter signature motif; other site 1052684002452 Walker B; other site 1052684002453 D-loop; other site 1052684002454 H-loop/switch region; other site 1052684002455 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1052684002456 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1052684002457 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1052684002458 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1052684002459 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1052684002460 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1052684002461 catalytic triad [active] 1052684002462 Spore germination protein; Region: Spore_permease; cl17796 1052684002463 Spore germination protein; Region: Spore_permease; cl17796 1052684002464 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052684002465 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052684002466 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052684002467 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1052684002468 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052684002469 GMP synthase; Reviewed; Region: guaA; PRK00074 1052684002470 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1052684002471 AMP/PPi binding site [chemical binding]; other site 1052684002472 candidate oxyanion hole; other site 1052684002473 catalytic triad [active] 1052684002474 potential glutamine specificity residues [chemical binding]; other site 1052684002475 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1052684002476 ATP Binding subdomain [chemical binding]; other site 1052684002477 Ligand Binding sites [chemical binding]; other site 1052684002478 Dimerization subdomain; other site 1052684002479 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1052684002480 conserved cys residue [active] 1052684002481 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052684002482 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684002483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684002484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684002485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052684002486 dimerization interface [polypeptide binding]; other site 1052684002487 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1052684002488 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1052684002489 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1052684002490 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 1052684002491 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1052684002492 dimer interface [polypeptide binding]; other site 1052684002493 active site 1052684002494 CoA binding pocket [chemical binding]; other site 1052684002495 DNA topoisomerase III; Provisional; Region: PRK07726 1052684002496 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1052684002497 active site 1052684002498 putative interdomain interaction site [polypeptide binding]; other site 1052684002499 putative metal-binding site [ion binding]; other site 1052684002500 putative nucleotide binding site [chemical binding]; other site 1052684002501 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1052684002502 domain I; other site 1052684002503 DNA binding groove [nucleotide binding] 1052684002504 phosphate binding site [ion binding]; other site 1052684002505 domain II; other site 1052684002506 domain III; other site 1052684002507 nucleotide binding site [chemical binding]; other site 1052684002508 catalytic site [active] 1052684002509 domain IV; other site 1052684002510 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1052684002511 active site 1052684002512 homotetramer interface [polypeptide binding]; other site 1052684002513 homodimer interface [polypeptide binding]; other site 1052684002514 Protein of unknown function (DUF4023); Region: DUF4023; pfam13215 1052684002515 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 1052684002516 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1052684002517 Ligand Binding Site [chemical binding]; other site 1052684002518 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1052684002519 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1052684002520 ATP-grasp domain; Region: ATP-grasp; pfam02222 1052684002521 adenylosuccinate lyase; Provisional; Region: PRK07492 1052684002522 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1052684002523 tetramer interface [polypeptide binding]; other site 1052684002524 active site 1052684002525 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 1052684002526 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1052684002527 ATP binding site [chemical binding]; other site 1052684002528 active site 1052684002529 substrate binding site [chemical binding]; other site 1052684002530 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 1052684002531 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 1052684002532 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1052684002533 putative active site [active] 1052684002534 catalytic triad [active] 1052684002535 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 1052684002536 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1052684002537 dimerization interface [polypeptide binding]; other site 1052684002538 ATP binding site [chemical binding]; other site 1052684002539 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1052684002540 dimerization interface [polypeptide binding]; other site 1052684002541 ATP binding site [chemical binding]; other site 1052684002542 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 1052684002543 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1052684002544 active site 1052684002545 tetramer interface [polypeptide binding]; other site 1052684002546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052684002547 active site 1052684002548 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1052684002549 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1052684002550 dimerization interface [polypeptide binding]; other site 1052684002551 putative ATP binding site [chemical binding]; other site 1052684002552 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1052684002553 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1052684002554 active site 1052684002555 substrate binding site [chemical binding]; other site 1052684002556 cosubstrate binding site; other site 1052684002557 catalytic site [active] 1052684002558 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1052684002559 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1052684002560 purine monophosphate binding site [chemical binding]; other site 1052684002561 dimer interface [polypeptide binding]; other site 1052684002562 putative catalytic residues [active] 1052684002563 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1052684002564 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1052684002565 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1052684002566 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1052684002567 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1052684002568 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684002569 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684002570 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1052684002571 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052684002572 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052684002573 substrate binding pocket [chemical binding]; other site 1052684002574 membrane-bound complex binding site; other site 1052684002575 hinge residues; other site 1052684002576 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052684002577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684002578 dimer interface [polypeptide binding]; other site 1052684002579 conserved gate region; other site 1052684002580 putative PBP binding loops; other site 1052684002581 ABC-ATPase subunit interface; other site 1052684002582 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052684002583 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052684002584 Walker A/P-loop; other site 1052684002585 ATP binding site [chemical binding]; other site 1052684002586 Q-loop/lid; other site 1052684002587 ABC transporter signature motif; other site 1052684002588 Walker B; other site 1052684002589 D-loop; other site 1052684002590 H-loop/switch region; other site 1052684002591 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 1052684002592 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052684002593 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684002594 ABC-ATPase subunit interface; other site 1052684002595 dimer interface [polypeptide binding]; other site 1052684002596 putative PBP binding regions; other site 1052684002597 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052684002598 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684002599 ABC-ATPase subunit interface; other site 1052684002600 dimer interface [polypeptide binding]; other site 1052684002601 putative PBP binding regions; other site 1052684002602 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684002603 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052684002604 siderophore binding site; other site 1052684002605 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1052684002606 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684002607 active site 1052684002608 phosphorylation site [posttranslational modification] 1052684002609 intermolecular recognition site; other site 1052684002610 dimerization interface [polypeptide binding]; other site 1052684002611 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 1052684002612 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052684002613 PAS domain; Region: PAS; smart00091 1052684002614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684002615 ATP binding site [chemical binding]; other site 1052684002616 Mg2+ binding site [ion binding]; other site 1052684002617 G-X-G motif; other site 1052684002618 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1052684002619 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052684002620 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052684002621 active site 1052684002622 catalytic tetrad [active] 1052684002623 Predicted integral membrane protein [Function unknown]; Region: COG5658 1052684002624 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1052684002625 SdpI/YhfL protein family; Region: SdpI; pfam13630 1052684002626 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684002627 dimerization interface [polypeptide binding]; other site 1052684002628 putative DNA binding site [nucleotide binding]; other site 1052684002629 putative Zn2+ binding site [ion binding]; other site 1052684002630 putative hydrolase; Provisional; Region: PRK11460 1052684002631 Predicted esterase [General function prediction only]; Region: COG0400 1052684002632 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 1052684002633 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684002634 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684002635 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684002636 dimer interface [polypeptide binding]; other site 1052684002637 conserved gate region; other site 1052684002638 putative PBP binding loops; other site 1052684002639 ABC-ATPase subunit interface; other site 1052684002640 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684002641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684002642 dimer interface [polypeptide binding]; other site 1052684002643 conserved gate region; other site 1052684002644 putative PBP binding loops; other site 1052684002645 ABC-ATPase subunit interface; other site 1052684002646 threonine dehydratase; Validated; Region: PRK08639 1052684002647 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1052684002648 tetramer interface [polypeptide binding]; other site 1052684002649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684002650 catalytic residue [active] 1052684002651 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1052684002652 putative Ile/Val binding site [chemical binding]; other site 1052684002653 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1052684002654 substrate binding site [chemical binding]; other site 1052684002655 active site 1052684002656 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052684002657 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684002658 ABC-ATPase subunit interface; other site 1052684002659 dimer interface [polypeptide binding]; other site 1052684002660 putative PBP binding regions; other site 1052684002661 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052684002662 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684002663 ABC-ATPase subunit interface; other site 1052684002664 dimer interface [polypeptide binding]; other site 1052684002665 putative PBP binding regions; other site 1052684002666 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684002667 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684002668 intersubunit interface [polypeptide binding]; other site 1052684002669 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1052684002670 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052684002671 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1052684002672 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1052684002673 putative active site [active] 1052684002674 metal binding site [ion binding]; metal-binding site 1052684002675 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 1052684002676 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 1052684002677 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1052684002678 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052684002679 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052684002680 substrate binding pocket [chemical binding]; other site 1052684002681 membrane-bound complex binding site; other site 1052684002682 hinge residues; other site 1052684002683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684002684 dimer interface [polypeptide binding]; other site 1052684002685 conserved gate region; other site 1052684002686 putative PBP binding loops; other site 1052684002687 ABC-ATPase subunit interface; other site 1052684002688 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052684002689 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052684002690 Walker A/P-loop; other site 1052684002691 ATP binding site [chemical binding]; other site 1052684002692 Q-loop/lid; other site 1052684002693 ABC transporter signature motif; other site 1052684002694 Walker B; other site 1052684002695 D-loop; other site 1052684002696 H-loop/switch region; other site 1052684002697 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1052684002698 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 1052684002699 oligomer interface [polypeptide binding]; other site 1052684002700 metal binding site [ion binding]; metal-binding site 1052684002701 metal binding site [ion binding]; metal-binding site 1052684002702 putative Cl binding site [ion binding]; other site 1052684002703 aspartate ring; other site 1052684002704 basic sphincter; other site 1052684002705 hydrophobic gate; other site 1052684002706 periplasmic entrance; other site 1052684002707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 1052684002708 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1052684002709 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1052684002710 putative active site [active] 1052684002711 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1052684002712 putative active site [active] 1052684002713 putative lipid kinase; Reviewed; Region: PRK13337 1052684002714 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1052684002715 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 1052684002716 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 1052684002717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684002718 S-adenosylmethionine binding site [chemical binding]; other site 1052684002719 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 1052684002720 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1052684002721 FMN binding site [chemical binding]; other site 1052684002722 active site 1052684002723 catalytic residues [active] 1052684002724 substrate binding site [chemical binding]; other site 1052684002725 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052684002726 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684002727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684002728 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684002729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684002730 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1052684002731 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 1052684002732 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 1052684002733 Plasmodium subtelomeric family (PST-A); Region: PST-A; TIGR01607 1052684002734 Predicted transcriptional regulator [Transcription]; Region: COG2378 1052684002735 HTH domain; Region: HTH_11; pfam08279 1052684002736 WYL domain; Region: WYL; pfam13280 1052684002737 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1052684002738 dimer interface [polypeptide binding]; other site 1052684002739 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1052684002740 hypothetical protein; Validated; Region: PRK00029 1052684002741 short chain dehydrogenase; Provisional; Region: PRK12747 1052684002742 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1052684002743 NADP binding site [chemical binding]; other site 1052684002744 homodimer interface [polypeptide binding]; other site 1052684002745 active site 1052684002746 substrate binding site [chemical binding]; other site 1052684002747 putative transport protein YifK; Provisional; Region: PRK10746 1052684002748 S-layer homology domain; Region: SLH; pfam00395 1052684002749 S-layer homology domain; Region: SLH; pfam00395 1052684002750 Domain of Unknown Function with PDB structure (DUF3863); Region: DUF3863; pfam12979 1052684002751 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1052684002752 dimer interface [polypeptide binding]; other site 1052684002753 FMN binding site [chemical binding]; other site 1052684002754 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684002755 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052684002756 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684002757 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684002758 intersubunit interface [polypeptide binding]; other site 1052684002759 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1052684002760 Phosphotransferase enzyme family; Region: APH; pfam01636 1052684002761 active site 1052684002762 substrate binding site [chemical binding]; other site 1052684002763 ATP binding site [chemical binding]; other site 1052684002764 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1052684002765 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1052684002766 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684002767 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 1052684002768 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 1052684002769 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1052684002770 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1052684002771 homodimer interface [polypeptide binding]; other site 1052684002772 NADP binding site [chemical binding]; other site 1052684002773 substrate binding site [chemical binding]; other site 1052684002774 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 1052684002775 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 1052684002776 putative di-iron ligands [ion binding]; other site 1052684002777 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1052684002778 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052684002779 Histidine kinase; Region: HisKA_3; pfam07730 1052684002780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684002781 ATP binding site [chemical binding]; other site 1052684002782 Mg2+ binding site [ion binding]; other site 1052684002783 G-X-G motif; other site 1052684002784 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052684002785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684002786 active site 1052684002787 phosphorylation site [posttranslational modification] 1052684002788 intermolecular recognition site; other site 1052684002789 dimerization interface [polypeptide binding]; other site 1052684002790 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052684002791 DNA binding residues [nucleotide binding] 1052684002792 dimerization interface [polypeptide binding]; other site 1052684002793 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1052684002794 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1052684002795 Substrate-binding site [chemical binding]; other site 1052684002796 Substrate specificity [chemical binding]; other site 1052684002797 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 1052684002798 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 1052684002799 Substrate-binding site [chemical binding]; other site 1052684002800 Substrate specificity [chemical binding]; other site 1052684002801 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052684002802 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684002803 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1052684002804 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052684002805 active site 1052684002806 metal binding site [ion binding]; metal-binding site 1052684002807 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 1052684002808 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 1052684002809 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1052684002810 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1052684002811 shikimate binding site; other site 1052684002812 NAD(P) binding site [chemical binding]; other site 1052684002813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684002814 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684002815 putative substrate translocation pore; other site 1052684002816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684002817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684002818 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1052684002819 putative dimerization interface [polypeptide binding]; other site 1052684002820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684002821 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684002822 putative substrate translocation pore; other site 1052684002823 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1052684002824 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1052684002825 active site 1052684002826 catalytic residue [active] 1052684002827 dimer interface [polypeptide binding]; other site 1052684002828 shikimate kinase; Reviewed; Region: aroK; PRK00131 1052684002829 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1052684002830 ADP binding site [chemical binding]; other site 1052684002831 magnesium binding site [ion binding]; other site 1052684002832 putative shikimate binding site; other site 1052684002833 Pectate lyase; Region: Pectate_lyase; pfam03211 1052684002834 Ecdysteroid kinase; Region: EcKinase; cl17738 1052684002835 Phosphotransferase enzyme family; Region: APH; pfam01636 1052684002836 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052684002837 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684002838 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052684002839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684002840 putative substrate translocation pore; other site 1052684002841 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052684002842 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052684002843 dimer interface [polypeptide binding]; other site 1052684002844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684002845 catalytic residue [active] 1052684002846 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052684002847 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052684002848 active site 1052684002849 catalytic tetrad [active] 1052684002850 WYL domain; Region: WYL; pfam13280 1052684002851 WYL domain; Region: WYL; pfam13280 1052684002852 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1052684002853 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 1052684002854 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 1052684002855 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 1052684002856 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1052684002857 active site 1052684002858 metal binding site [ion binding]; metal-binding site 1052684002859 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1052684002860 active site 1052684002861 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1052684002862 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1052684002863 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1052684002864 Walker A/P-loop; other site 1052684002865 ATP binding site [chemical binding]; other site 1052684002866 Q-loop/lid; other site 1052684002867 ABC transporter signature motif; other site 1052684002868 Walker B; other site 1052684002869 D-loop; other site 1052684002870 H-loop/switch region; other site 1052684002871 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1052684002872 Walker A/P-loop; other site 1052684002873 ATP binding site [chemical binding]; other site 1052684002874 Q-loop/lid; other site 1052684002875 ABC transporter signature motif; other site 1052684002876 Walker B; other site 1052684002877 D-loop; other site 1052684002878 H-loop/switch region; other site 1052684002879 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1052684002880 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1052684002881 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052684002882 Walker A/P-loop; other site 1052684002883 ATP binding site [chemical binding]; other site 1052684002884 Q-loop/lid; other site 1052684002885 ABC transporter signature motif; other site 1052684002886 Walker B; other site 1052684002887 D-loop; other site 1052684002888 H-loop/switch region; other site 1052684002889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684002890 dimer interface [polypeptide binding]; other site 1052684002891 conserved gate region; other site 1052684002892 ABC-ATPase subunit interface; other site 1052684002893 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1052684002894 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1052684002895 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1052684002896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684002897 Coenzyme A binding pocket [chemical binding]; other site 1052684002898 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052684002899 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684002900 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052684002901 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1052684002902 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1052684002903 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 1052684002904 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1052684002905 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1052684002906 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1052684002907 S-layer homology domain; Region: SLH; pfam00395 1052684002908 tetracycline repressor protein TetR; Provisional; Region: PRK13756 1052684002909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684002910 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1052684002911 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1052684002912 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 1052684002913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 1052684002914 hypothetical protein; Provisional; Region: PRK13660 1052684002915 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1052684002916 metal binding site [ion binding]; metal-binding site 1052684002917 active site 1052684002918 YvrJ protein family; Region: YvrJ; pfam12841 1052684002919 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1052684002920 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684002921 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052684002922 active site 1052684002923 motif I; other site 1052684002924 motif II; other site 1052684002925 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1052684002926 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1052684002927 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1052684002928 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052684002929 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1052684002930 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 1052684002931 acyl-activating enzyme (AAE) consensus motif; other site 1052684002932 putative AMP binding site [chemical binding]; other site 1052684002933 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684002934 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684002935 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052684002936 active site 1052684002937 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684002938 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1052684002939 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052684002940 inhibitor-cofactor binding pocket; inhibition site 1052684002941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684002942 catalytic residue [active] 1052684002943 Condensation domain; Region: Condensation; pfam00668 1052684002944 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684002945 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684002946 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052684002947 CoA binding site [chemical binding]; other site 1052684002948 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684002949 Condensation domain; Region: Condensation; pfam00668 1052684002950 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684002951 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684002952 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684002953 acyl-activating enzyme (AAE) consensus motif; other site 1052684002954 AMP binding site [chemical binding]; other site 1052684002955 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684002956 Condensation domain; Region: Condensation; pfam00668 1052684002957 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684002958 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684002959 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684002960 acyl-activating enzyme (AAE) consensus motif; other site 1052684002961 AMP binding site [chemical binding]; other site 1052684002962 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684002963 Condensation domain; Region: Condensation; pfam00668 1052684002964 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684002965 Condensation domain; Region: Condensation; pfam00668 1052684002966 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684002967 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684002968 acyl-activating enzyme (AAE) consensus motif; other site 1052684002969 AMP binding site [chemical binding]; other site 1052684002970 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684002971 Condensation domain; Region: Condensation; pfam00668 1052684002972 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684002973 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684002974 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684002975 acyl-activating enzyme (AAE) consensus motif; other site 1052684002976 AMP binding site [chemical binding]; other site 1052684002977 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684002978 Condensation domain; Region: Condensation; pfam00668 1052684002979 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684002980 peptide synthase; Provisional; Region: PRK12467 1052684002981 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684002982 acyl-activating enzyme (AAE) consensus motif; other site 1052684002983 AMP binding site [chemical binding]; other site 1052684002984 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684002985 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684002986 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052684002987 acyl-activating enzyme (AAE) consensus motif; other site 1052684002988 AMP binding site [chemical binding]; other site 1052684002989 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684002990 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684002991 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684002992 acyl-activating enzyme (AAE) consensus motif; other site 1052684002993 AMP binding site [chemical binding]; other site 1052684002994 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684002995 Condensation domain; Region: Condensation; pfam00668 1052684002996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684002997 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052684002998 putative substrate translocation pore; other site 1052684002999 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684003000 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1052684003001 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052684003002 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052684003003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684003004 Walker A/P-loop; other site 1052684003005 ATP binding site [chemical binding]; other site 1052684003006 Q-loop/lid; other site 1052684003007 ABC transporter signature motif; other site 1052684003008 Walker B; other site 1052684003009 D-loop; other site 1052684003010 H-loop/switch region; other site 1052684003011 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 1052684003012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052684003013 Histidine kinase; Region: HisKA_3; pfam07730 1052684003014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684003015 ATP binding site [chemical binding]; other site 1052684003016 Mg2+ binding site [ion binding]; other site 1052684003017 G-X-G motif; other site 1052684003018 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052684003019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684003020 active site 1052684003021 phosphorylation site [posttranslational modification] 1052684003022 intermolecular recognition site; other site 1052684003023 dimerization interface [polypeptide binding]; other site 1052684003024 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052684003025 DNA binding residues [nucleotide binding] 1052684003026 dimerization interface [polypeptide binding]; other site 1052684003027 tellurite resistance protein terB; Region: terB; cd07176 1052684003028 putative metal binding site [ion binding]; other site 1052684003029 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052684003030 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052684003031 putative metal binding site [ion binding]; other site 1052684003032 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052684003033 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052684003034 putative metal binding site [ion binding]; other site 1052684003035 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052684003036 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052684003037 putative metal binding site [ion binding]; other site 1052684003038 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052684003039 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052684003040 putative metal binding site [ion binding]; other site 1052684003041 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 1052684003042 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052684003043 putative metal binding site [ion binding]; other site 1052684003044 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 1052684003045 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1052684003046 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 1052684003047 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1052684003048 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1052684003049 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1052684003050 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1052684003051 zinc binding site [ion binding]; other site 1052684003052 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1052684003053 metal ion-dependent adhesion site (MIDAS); other site 1052684003054 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1052684003055 peptide binding site [polypeptide binding]; other site 1052684003056 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1052684003057 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1052684003058 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684003059 putative PBP binding loops; other site 1052684003060 dimer interface [polypeptide binding]; other site 1052684003061 ABC-ATPase subunit interface; other site 1052684003062 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052684003063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684003064 dimer interface [polypeptide binding]; other site 1052684003065 conserved gate region; other site 1052684003066 putative PBP binding loops; other site 1052684003067 ABC-ATPase subunit interface; other site 1052684003068 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052684003069 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052684003070 substrate binding pocket [chemical binding]; other site 1052684003071 membrane-bound complex binding site; other site 1052684003072 hinge residues; other site 1052684003073 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052684003074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684003075 dimer interface [polypeptide binding]; other site 1052684003076 conserved gate region; other site 1052684003077 putative PBP binding loops; other site 1052684003078 ABC-ATPase subunit interface; other site 1052684003079 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052684003080 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052684003081 Walker A/P-loop; other site 1052684003082 ATP binding site [chemical binding]; other site 1052684003083 Q-loop/lid; other site 1052684003084 ABC transporter signature motif; other site 1052684003085 Walker B; other site 1052684003086 D-loop; other site 1052684003087 H-loop/switch region; other site 1052684003088 Cupin domain; Region: Cupin_2; pfam07883 1052684003089 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684003090 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684003091 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052684003092 EamA-like transporter family; Region: EamA; pfam00892 1052684003093 EamA-like transporter family; Region: EamA; pfam00892 1052684003094 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1052684003095 dimer interface [polypeptide binding]; other site 1052684003096 putative tRNA-binding site [nucleotide binding]; other site 1052684003097 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1052684003098 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684003099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684003100 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684003101 putative substrate translocation pore; other site 1052684003102 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1052684003103 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1052684003104 putative NAD(P) binding site [chemical binding]; other site 1052684003105 putative substrate binding site [chemical binding]; other site 1052684003106 catalytic Zn binding site [ion binding]; other site 1052684003107 structural Zn binding site [ion binding]; other site 1052684003108 dimer interface [polypeptide binding]; other site 1052684003109 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052684003110 EamA-like transporter family; Region: EamA; pfam00892 1052684003111 EamA-like transporter family; Region: EamA; pfam00892 1052684003112 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684003113 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684003114 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684003115 DinB family; Region: DinB; cl17821 1052684003116 short chain dehydrogenase; Provisional; Region: PRK07454 1052684003117 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1052684003118 NADP binding site [chemical binding]; other site 1052684003119 substrate binding site [chemical binding]; other site 1052684003120 active site 1052684003121 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684003122 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052684003123 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1052684003124 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684003125 active site 1052684003126 motif I; other site 1052684003127 motif II; other site 1052684003128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684003129 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684003130 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684003131 DNA binding site [nucleotide binding] 1052684003132 domain linker motif; other site 1052684003133 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052684003134 ligand binding site [chemical binding]; other site 1052684003135 dimerization interface [polypeptide binding]; other site 1052684003136 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1052684003137 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1052684003138 calcium mediated ligand binding site; other site 1052684003139 intermolecular salt bridges; other site 1052684003140 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1052684003141 alpha-galactosidase; Provisional; Region: PRK15076 1052684003142 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1052684003143 NAD binding site [chemical binding]; other site 1052684003144 sugar binding site [chemical binding]; other site 1052684003145 divalent metal binding site [ion binding]; other site 1052684003146 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052684003147 dimer interface [polypeptide binding]; other site 1052684003148 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684003149 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1052684003150 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 1052684003151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684003152 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684003153 DNA binding residues [nucleotide binding] 1052684003154 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1052684003155 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 1052684003156 metal binding site [ion binding]; metal-binding site 1052684003157 active site 1052684003158 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684003159 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684003160 DNA binding site [nucleotide binding] 1052684003161 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052684003162 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684003163 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684003164 dimer interface [polypeptide binding]; other site 1052684003165 conserved gate region; other site 1052684003166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1052684003167 ABC-ATPase subunit interface; other site 1052684003168 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684003169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684003170 dimer interface [polypeptide binding]; other site 1052684003171 conserved gate region; other site 1052684003172 putative PBP binding loops; other site 1052684003173 ABC-ATPase subunit interface; other site 1052684003174 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684003175 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684003176 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1052684003177 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052684003178 substrate binding [chemical binding]; other site 1052684003179 active site 1052684003180 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052684003181 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1052684003182 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1052684003183 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1052684003184 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052684003185 active site 1052684003186 substrate binding [chemical binding]; other site 1052684003187 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052684003188 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 1052684003189 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 1052684003190 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684003191 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684003192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684003193 Walker A/P-loop; other site 1052684003194 ATP binding site [chemical binding]; other site 1052684003195 Q-loop/lid; other site 1052684003196 ABC transporter signature motif; other site 1052684003197 Walker B; other site 1052684003198 D-loop; other site 1052684003199 H-loop/switch region; other site 1052684003200 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684003201 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684003202 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1052684003203 Walker A/P-loop; other site 1052684003204 ATP binding site [chemical binding]; other site 1052684003205 Q-loop/lid; other site 1052684003206 ABC transporter signature motif; other site 1052684003207 Walker B; other site 1052684003208 D-loop; other site 1052684003209 H-loop/switch region; other site 1052684003210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684003211 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684003212 putative substrate translocation pore; other site 1052684003213 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684003214 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684003215 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684003216 Cupin domain; Region: Cupin_2; pfam07883 1052684003217 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684003218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684003219 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684003220 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1052684003221 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684003222 putative substrate translocation pore; other site 1052684003223 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1052684003224 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684003225 active site 1052684003226 phosphorylation site [posttranslational modification] 1052684003227 intermolecular recognition site; other site 1052684003228 dimerization interface [polypeptide binding]; other site 1052684003229 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684003230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684003231 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684003232 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684003233 dimerization interface [polypeptide binding]; other site 1052684003234 Histidine kinase; Region: His_kinase; pfam06580 1052684003235 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684003236 ATP binding site [chemical binding]; other site 1052684003237 Mg2+ binding site [ion binding]; other site 1052684003238 G-X-G motif; other site 1052684003239 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1052684003240 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1052684003241 ligand binding site [chemical binding]; other site 1052684003242 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1052684003243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684003244 active site 1052684003245 motif I; other site 1052684003246 motif II; other site 1052684003247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684003248 alpha-galactosidase; Provisional; Region: PRK15076 1052684003249 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1052684003250 NAD binding site [chemical binding]; other site 1052684003251 sugar binding site [chemical binding]; other site 1052684003252 divalent metal binding site [ion binding]; other site 1052684003253 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052684003254 dimer interface [polypeptide binding]; other site 1052684003255 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 1052684003256 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 1052684003257 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684003258 Interdomain contacts; other site 1052684003259 Cytokine receptor motif; other site 1052684003260 Cellulose binding domain; Region: CBM_3; pfam00942 1052684003261 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1052684003262 active site 1052684003263 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052684003264 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1052684003265 putative active site [active] 1052684003266 heme pocket [chemical binding]; other site 1052684003267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052684003268 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 1052684003269 putative active site [active] 1052684003270 heme pocket [chemical binding]; other site 1052684003271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052684003272 putative active site [active] 1052684003273 heme pocket [chemical binding]; other site 1052684003274 PAS domain S-box; Region: sensory_box; TIGR00229 1052684003275 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052684003276 putative active site [active] 1052684003277 heme pocket [chemical binding]; other site 1052684003278 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052684003279 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052684003280 putative active site [active] 1052684003281 heme pocket [chemical binding]; other site 1052684003282 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684003283 dimer interface [polypeptide binding]; other site 1052684003284 phosphorylation site [posttranslational modification] 1052684003285 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684003286 ATP binding site [chemical binding]; other site 1052684003287 Mg2+ binding site [ion binding]; other site 1052684003288 G-X-G motif; other site 1052684003289 Predicted transcriptional regulators [Transcription]; Region: COG1725 1052684003290 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684003291 DNA-binding site [nucleotide binding]; DNA binding site 1052684003292 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052684003293 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052684003294 Walker A/P-loop; other site 1052684003295 ATP binding site [chemical binding]; other site 1052684003296 Q-loop/lid; other site 1052684003297 ABC transporter signature motif; other site 1052684003298 Walker B; other site 1052684003299 D-loop; other site 1052684003300 H-loop/switch region; other site 1052684003301 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1052684003302 PBP superfamily domain; Region: PBP_like_2; cl17296 1052684003303 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1052684003304 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052684003305 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052684003306 active site 1052684003307 catalytic tetrad [active] 1052684003308 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1052684003309 active site 1052684003310 SUMO-1 interface [polypeptide binding]; other site 1052684003311 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1052684003312 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1052684003313 hexamer interface [polypeptide binding]; other site 1052684003314 ligand binding site [chemical binding]; other site 1052684003315 putative active site [active] 1052684003316 NAD(P) binding site [chemical binding]; other site 1052684003317 DRTGG domain; Region: DRTGG; pfam07085 1052684003318 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 1052684003319 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1052684003320 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684003321 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1052684003322 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1052684003323 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1052684003324 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1052684003325 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 1052684003326 active site 1052684003327 catalytic triad [active] 1052684003328 oxyanion hole [active] 1052684003329 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052684003330 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052684003331 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052684003332 Transporter associated domain; Region: CorC_HlyC; smart01091 1052684003333 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1052684003334 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684003335 dimerization interface [polypeptide binding]; other site 1052684003336 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684003337 dimer interface [polypeptide binding]; other site 1052684003338 putative CheW interface [polypeptide binding]; other site 1052684003339 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 1052684003340 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052684003341 classical (c) SDRs; Region: SDR_c; cd05233 1052684003342 NAD(P) binding site [chemical binding]; other site 1052684003343 active site 1052684003344 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1052684003345 MgtC family; Region: MgtC; pfam02308 1052684003346 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1052684003347 active site 1052684003348 drug efflux system protein MdtG; Provisional; Region: PRK09874 1052684003349 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684003350 putative substrate translocation pore; other site 1052684003351 EamA-like transporter family; Region: EamA; pfam00892 1052684003352 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052684003353 EamA-like transporter family; Region: EamA; pfam00892 1052684003354 Predicted transcriptional regulators [Transcription]; Region: COG1378 1052684003355 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 1052684003356 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 1052684003357 C-terminal domain interface [polypeptide binding]; other site 1052684003358 sugar binding site [chemical binding]; other site 1052684003359 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 1052684003360 Chorismate mutase type II; Region: CM_2; cl00693 1052684003361 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1052684003362 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684003363 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684003364 dimer interface [polypeptide binding]; other site 1052684003365 phosphorylation site [posttranslational modification] 1052684003366 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684003367 ATP binding site [chemical binding]; other site 1052684003368 Mg2+ binding site [ion binding]; other site 1052684003369 G-X-G motif; other site 1052684003370 Catalytic NodB homology domain of Streptomyces lividans acetylxylan esterase and its bacterial homologs; Region: CE4_SlAXE_like; cd10953 1052684003371 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052684003372 NodB motif; other site 1052684003373 active site 1052684003374 catalytic site [active] 1052684003375 Zn binding site [ion binding]; other site 1052684003376 dimer interface [polypeptide binding]; other site 1052684003377 Carbohydrate Binding Module families 36 (CBM36) and 6 (CBM6); appended mainly to glycoside hydrolase family 11 (GH11) domains; xylan binding; Region: CBM6_36_xylanase-like; cd04078 1052684003378 Ca binding site [ion binding]; other site 1052684003379 Ca binding site (active) [ion binding]; other site 1052684003380 ligand binding site [chemical binding]; other site 1052684003381 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1052684003382 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1052684003383 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1052684003384 conserved cys residue [active] 1052684003385 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1052684003386 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1052684003387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684003388 non-specific DNA binding site [nucleotide binding]; other site 1052684003389 salt bridge; other site 1052684003390 sequence-specific DNA binding site [nucleotide binding]; other site 1052684003391 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1052684003392 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1052684003393 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 1052684003394 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1052684003395 putative ligand binding site [chemical binding]; other site 1052684003396 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052684003397 Cache domain; Region: Cache_1; pfam02743 1052684003398 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684003399 dimerization interface [polypeptide binding]; other site 1052684003400 Histidine kinase; Region: His_kinase; pfam06580 1052684003401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684003402 ATP binding site [chemical binding]; other site 1052684003403 Mg2+ binding site [ion binding]; other site 1052684003404 G-X-G motif; other site 1052684003405 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684003406 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684003407 active site 1052684003408 phosphorylation site [posttranslational modification] 1052684003409 intermolecular recognition site; other site 1052684003410 dimerization interface [polypeptide binding]; other site 1052684003411 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684003412 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684003413 hydroxylamine reductase; Provisional; Region: PRK12310 1052684003414 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1052684003415 ACS interaction site; other site 1052684003416 CODH interaction site; other site 1052684003417 metal cluster binding site [ion binding]; other site 1052684003418 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684003419 non-specific DNA binding site [nucleotide binding]; other site 1052684003420 salt bridge; other site 1052684003421 sequence-specific DNA binding site [nucleotide binding]; other site 1052684003422 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 1052684003423 metal binding site [ion binding]; metal-binding site 1052684003424 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 1052684003425 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1052684003426 putative ligand binding site [chemical binding]; other site 1052684003427 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1052684003428 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1052684003429 Walker A/P-loop; other site 1052684003430 ATP binding site [chemical binding]; other site 1052684003431 Q-loop/lid; other site 1052684003432 ABC transporter signature motif; other site 1052684003433 Walker B; other site 1052684003434 D-loop; other site 1052684003435 H-loop/switch region; other site 1052684003436 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1052684003437 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1052684003438 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1052684003439 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1052684003440 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1052684003441 TM-ABC transporter signature motif; other site 1052684003442 short chain dehydrogenase; Provisional; Region: PRK06701 1052684003443 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1052684003444 NAD binding site [chemical binding]; other site 1052684003445 metal binding site [ion binding]; metal-binding site 1052684003446 active site 1052684003447 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1052684003448 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1052684003449 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1052684003450 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684003451 putative DNA binding site [nucleotide binding]; other site 1052684003452 putative Zn2+ binding site [ion binding]; other site 1052684003453 AsnC family; Region: AsnC_trans_reg; pfam01037 1052684003454 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052684003455 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052684003456 EcsC protein family; Region: EcsC; pfam12787 1052684003457 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684003458 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684003459 putative substrate translocation pore; other site 1052684003460 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 1052684003461 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1052684003462 active site 1052684003463 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1052684003464 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052684003465 active site turn [active] 1052684003466 phosphorylation site [posttranslational modification] 1052684003467 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684003468 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1052684003469 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1052684003470 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1052684003471 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1052684003472 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052684003473 substrate binding [chemical binding]; other site 1052684003474 active site 1052684003475 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052684003476 Cupin domain; Region: Cupin_2; pfam07883 1052684003477 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684003478 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684003479 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684003480 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 1052684003481 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 1052684003482 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684003483 FeS/SAM binding site; other site 1052684003484 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1052684003485 active site 1052684003486 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1052684003487 Ligand Binding Site [chemical binding]; other site 1052684003488 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 1052684003489 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1052684003490 Predicted transcriptional regulator [Transcription]; Region: COG2378 1052684003491 HTH domain; Region: HTH_11; pfam08279 1052684003492 WYL domain; Region: WYL; pfam13280 1052684003493 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1052684003494 active site 1052684003495 catalytic site [active] 1052684003496 substrate binding site [chemical binding]; other site 1052684003497 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1052684003498 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 1052684003499 putative active site [active] 1052684003500 putative metal binding site [ion binding]; other site 1052684003501 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052684003502 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052684003503 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1052684003504 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052684003505 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684003506 non-specific DNA binding site [nucleotide binding]; other site 1052684003507 salt bridge; other site 1052684003508 sequence-specific DNA binding site [nucleotide binding]; other site 1052684003509 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1052684003510 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1052684003511 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1052684003512 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1052684003513 Phage XkdN-like protein; Region: XkdN; pfam08890 1052684003514 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 1052684003515 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052684003516 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1052684003517 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1052684003518 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 1052684003519 Holin family; Region: Phage_holin_4; pfam05105 1052684003520 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1052684003521 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1052684003522 active site 1052684003523 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1052684003524 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1052684003525 peptide binding site [polypeptide binding]; other site 1052684003526 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052684003527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684003528 dimer interface [polypeptide binding]; other site 1052684003529 conserved gate region; other site 1052684003530 putative PBP binding loops; other site 1052684003531 ABC-ATPase subunit interface; other site 1052684003532 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052684003533 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052684003534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684003535 dimer interface [polypeptide binding]; other site 1052684003536 conserved gate region; other site 1052684003537 putative PBP binding loops; other site 1052684003538 ABC-ATPase subunit interface; other site 1052684003539 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684003540 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684003541 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684003542 Walker A/P-loop; other site 1052684003543 ATP binding site [chemical binding]; other site 1052684003544 Q-loop/lid; other site 1052684003545 ABC transporter signature motif; other site 1052684003546 Walker B; other site 1052684003547 D-loop; other site 1052684003548 H-loop/switch region; other site 1052684003549 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684003550 Coenzyme A binding pocket [chemical binding]; other site 1052684003551 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 1052684003552 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052684003553 DNA binding residues [nucleotide binding] 1052684003554 dimer interface [polypeptide binding]; other site 1052684003555 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052684003556 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 1052684003557 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052684003558 Zn2+ binding site [ion binding]; other site 1052684003559 Mg2+ binding site [ion binding]; other site 1052684003560 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1052684003561 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1052684003562 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052684003563 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 1052684003564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684003565 S-adenosylmethionine binding site [chemical binding]; other site 1052684003566 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1052684003567 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1052684003568 NAD binding site [chemical binding]; other site 1052684003569 ligand binding site [chemical binding]; other site 1052684003570 catalytic site [active] 1052684003571 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 1052684003572 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1052684003573 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1052684003574 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052684003575 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1052684003576 metal-dependent hydrolase; Provisional; Region: PRK00685 1052684003577 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1052684003578 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1052684003579 active site 1052684003580 dimer interface [polypeptide binding]; other site 1052684003581 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1052684003582 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1052684003583 active site 1052684003584 FMN binding site [chemical binding]; other site 1052684003585 substrate binding site [chemical binding]; other site 1052684003586 3Fe-4S cluster binding site [ion binding]; other site 1052684003587 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1052684003588 domain interface; other site 1052684003589 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052684003590 Histidine kinase; Region: HisKA_3; pfam07730 1052684003591 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684003592 ATP binding site [chemical binding]; other site 1052684003593 Mg2+ binding site [ion binding]; other site 1052684003594 G-X-G motif; other site 1052684003595 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052684003596 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684003597 active site 1052684003598 phosphorylation site [posttranslational modification] 1052684003599 intermolecular recognition site; other site 1052684003600 dimerization interface [polypeptide binding]; other site 1052684003601 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052684003602 DNA binding residues [nucleotide binding] 1052684003603 dimerization interface [polypeptide binding]; other site 1052684003604 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1052684003605 Chain length determinant protein; Region: Wzz; cl15801 1052684003606 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1052684003607 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1052684003608 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052684003609 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1052684003610 active site 1052684003611 tetramer interface; other site 1052684003612 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1052684003613 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1052684003614 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1052684003615 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052684003616 active site 1052684003617 O-Antigen ligase; Region: Wzy_C; pfam04932 1052684003618 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1052684003619 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1052684003620 O-Antigen ligase; Region: Wzy_C; pfam04932 1052684003621 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052684003622 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1052684003623 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052684003624 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1052684003625 putative metal binding site; other site 1052684003626 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684003627 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052684003628 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684003629 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052684003630 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684003631 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1052684003632 putative ADP-binding pocket [chemical binding]; other site 1052684003633 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1052684003634 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1052684003635 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052684003636 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1052684003637 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052684003638 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1052684003639 active site 1052684003640 Cupin domain; Region: Cupin_2; cl17218 1052684003641 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1052684003642 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 1052684003643 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1052684003644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684003645 non-specific DNA binding site [nucleotide binding]; other site 1052684003646 salt bridge; other site 1052684003647 sequence-specific DNA binding site [nucleotide binding]; other site 1052684003648 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1052684003649 Chain length determinant protein; Region: Wzz; cl15801 1052684003650 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1052684003651 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1052684003652 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1052684003653 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1052684003654 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1052684003655 NADP binding site [chemical binding]; other site 1052684003656 active site 1052684003657 putative substrate binding site [chemical binding]; other site 1052684003658 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1052684003659 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1052684003660 NADP-binding site; other site 1052684003661 homotetramer interface [polypeptide binding]; other site 1052684003662 substrate binding site [chemical binding]; other site 1052684003663 homodimer interface [polypeptide binding]; other site 1052684003664 active site 1052684003665 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052684003666 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1052684003667 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684003668 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052684003669 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 1052684003670 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684003671 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1052684003672 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1052684003673 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1052684003674 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1052684003675 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052684003676 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1052684003677 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1052684003678 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052684003679 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684003680 Walker A/P-loop; other site 1052684003681 ATP binding site [chemical binding]; other site 1052684003682 Q-loop/lid; other site 1052684003683 ABC transporter signature motif; other site 1052684003684 Walker B; other site 1052684003685 D-loop; other site 1052684003686 H-loop/switch region; other site 1052684003687 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052684003688 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1052684003689 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052684003690 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1052684003691 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 1052684003692 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1052684003693 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 1052684003694 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1052684003695 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052684003696 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1052684003697 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1052684003698 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1052684003699 putative active site [active] 1052684003700 catalytic site [active] 1052684003701 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1052684003702 putative active site [active] 1052684003703 catalytic site [active] 1052684003704 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052684003705 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052684003706 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052684003707 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052684003708 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 1052684003709 nucleotide binding site [chemical binding]; other site 1052684003710 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1052684003711 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1052684003712 active site 1052684003713 dimer interface [polypeptide binding]; other site 1052684003714 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 1052684003715 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1052684003716 Ligand Binding Site [chemical binding]; other site 1052684003717 Molecular Tunnel; other site 1052684003718 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1052684003719 active site 1052684003720 metal-binding site [ion binding] 1052684003721 nucleotide-binding site [chemical binding]; other site 1052684003722 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 1052684003723 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 1052684003724 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684003725 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684003726 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684003727 Walker A/P-loop; other site 1052684003728 ATP binding site [chemical binding]; other site 1052684003729 Q-loop/lid; other site 1052684003730 ABC transporter signature motif; other site 1052684003731 Walker B; other site 1052684003732 D-loop; other site 1052684003733 H-loop/switch region; other site 1052684003734 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 1052684003735 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 1052684003736 putative DNA binding site [nucleotide binding]; other site 1052684003737 putative homodimer interface [polypeptide binding]; other site 1052684003738 Small acid-soluble spore protein H family; Region: SspH; pfam08141 1052684003739 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1052684003740 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1052684003741 acetoacetate decarboxylase; Provisional; Region: PRK02265 1052684003742 putative acyltransferase; Provisional; Region: PRK05790 1052684003743 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1052684003744 dimer interface [polypeptide binding]; other site 1052684003745 active site 1052684003746 Isochorismatase family; Region: Isochorismatase; pfam00857 1052684003747 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1052684003748 catalytic triad [active] 1052684003749 conserved cis-peptide bond; other site 1052684003750 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1052684003751 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1052684003752 Glycoprotease family; Region: Peptidase_M22; pfam00814 1052684003753 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1052684003754 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684003755 Coenzyme A binding pocket [chemical binding]; other site 1052684003756 UGMP family protein; Validated; Region: PRK09604 1052684003757 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1052684003758 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1052684003759 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052684003760 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052684003761 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052684003762 ABC transporter; Region: ABC_tran_2; pfam12848 1052684003763 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052684003764 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1052684003765 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1052684003766 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1052684003767 trimer interface [polypeptide binding]; other site 1052684003768 dimer interface [polypeptide binding]; other site 1052684003769 putative active site [active] 1052684003770 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1052684003771 MPT binding site; other site 1052684003772 trimer interface [polypeptide binding]; other site 1052684003773 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 1052684003774 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1052684003775 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1052684003776 oligomerisation interface [polypeptide binding]; other site 1052684003777 mobile loop; other site 1052684003778 roof hairpin; other site 1052684003779 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1052684003780 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1052684003781 ring oligomerisation interface [polypeptide binding]; other site 1052684003782 ATP/Mg binding site [chemical binding]; other site 1052684003783 stacking interactions; other site 1052684003784 hinge regions; other site 1052684003785 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 1052684003786 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 1052684003787 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684003788 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684003789 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684003790 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052684003791 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052684003792 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1052684003793 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684003794 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684003795 dimer interface [polypeptide binding]; other site 1052684003796 putative PBP binding loops; other site 1052684003797 ABC-ATPase subunit interface; other site 1052684003798 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684003799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684003800 dimer interface [polypeptide binding]; other site 1052684003801 conserved gate region; other site 1052684003802 putative PBP binding loops; other site 1052684003803 ABC-ATPase subunit interface; other site 1052684003804 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684003805 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1052684003806 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684003807 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684003808 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 1052684003809 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1052684003810 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052684003811 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1052684003812 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1052684003813 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1052684003814 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1052684003815 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684003816 dimer interface [polypeptide binding]; other site 1052684003817 conserved gate region; other site 1052684003818 putative PBP binding loops; other site 1052684003819 ABC-ATPase subunit interface; other site 1052684003820 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1052684003821 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1052684003822 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 1052684003823 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1052684003824 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1052684003825 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1052684003826 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 1052684003827 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1052684003828 Walker A/P-loop; other site 1052684003829 ATP binding site [chemical binding]; other site 1052684003830 Q-loop/lid; other site 1052684003831 ABC transporter signature motif; other site 1052684003832 Walker B; other site 1052684003833 D-loop; other site 1052684003834 H-loop/switch region; other site 1052684003835 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1052684003836 Predicted transcriptional regulators [Transcription]; Region: COG1510 1052684003837 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1052684003838 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1052684003839 substrate binding pocket [chemical binding]; other site 1052684003840 catalytic triad [active] 1052684003841 Cache domain; Region: Cache_1; pfam02743 1052684003842 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684003843 dimerization interface [polypeptide binding]; other site 1052684003844 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684003845 dimer interface [polypeptide binding]; other site 1052684003846 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1052684003847 putative CheW interface [polypeptide binding]; other site 1052684003848 EamA-like transporter family; Region: EamA; pfam00892 1052684003849 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052684003850 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1052684003851 Walker A/P-loop; other site 1052684003852 ATP binding site [chemical binding]; other site 1052684003853 Q-loop/lid; other site 1052684003854 ABC transporter signature motif; other site 1052684003855 Walker B; other site 1052684003856 D-loop; other site 1052684003857 H-loop/switch region; other site 1052684003858 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684003859 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684003860 dimer interface [polypeptide binding]; other site 1052684003861 phosphorylation site [posttranslational modification] 1052684003862 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684003863 ATP binding site [chemical binding]; other site 1052684003864 Mg2+ binding site [ion binding]; other site 1052684003865 G-X-G motif; other site 1052684003866 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684003867 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684003868 active site 1052684003869 phosphorylation site [posttranslational modification] 1052684003870 intermolecular recognition site; other site 1052684003871 dimerization interface [polypeptide binding]; other site 1052684003872 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684003873 DNA binding site [nucleotide binding] 1052684003874 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1052684003875 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1052684003876 Potassium binding sites [ion binding]; other site 1052684003877 Cesium cation binding sites [ion binding]; other site 1052684003878 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684003879 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684003880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684003881 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684003882 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052684003883 intersubunit interface [polypeptide binding]; other site 1052684003884 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684003885 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052684003886 intersubunit interface [polypeptide binding]; other site 1052684003887 LysE type translocator; Region: LysE; pfam01810 1052684003888 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 1052684003889 alanine racemase; Reviewed; Region: alr; PRK00053 1052684003890 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1052684003891 active site 1052684003892 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052684003893 dimer interface [polypeptide binding]; other site 1052684003894 substrate binding site [chemical binding]; other site 1052684003895 catalytic residues [active] 1052684003896 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1052684003897 PemK-like protein; Region: PemK; pfam02452 1052684003898 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1052684003899 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1052684003900 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1052684003901 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1052684003902 RNA binding site [nucleotide binding]; other site 1052684003903 SprT homologues; Region: SprT; cl01182 1052684003904 hypothetical protein; Provisional; Region: PRK04351 1052684003905 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684003906 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052684003907 active site 1052684003908 motif I; other site 1052684003909 motif II; other site 1052684003910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684003911 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052684003912 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1052684003913 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1052684003914 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684003915 dimerization interface [polypeptide binding]; other site 1052684003916 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684003917 putative DNA binding site [nucleotide binding]; other site 1052684003918 putative Zn2+ binding site [ion binding]; other site 1052684003919 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052684003920 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684003921 non-specific DNA binding site [nucleotide binding]; other site 1052684003922 salt bridge; other site 1052684003923 sequence-specific DNA binding site [nucleotide binding]; other site 1052684003924 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052684003925 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684003926 non-specific DNA binding site [nucleotide binding]; other site 1052684003927 salt bridge; other site 1052684003928 sequence-specific DNA binding site [nucleotide binding]; other site 1052684003929 UreF; Region: UreF; pfam01730 1052684003930 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1052684003931 catalytic residues [active] 1052684003932 dimer interface [polypeptide binding]; other site 1052684003933 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1052684003934 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1052684003935 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052684003936 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1052684003937 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 1052684003938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684003939 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684003940 putative substrate translocation pore; other site 1052684003941 Predicted transcriptional regulators [Transcription]; Region: COG1695 1052684003942 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1052684003943 manganese transport protein MntH; Reviewed; Region: PRK00701 1052684003944 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1052684003945 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1052684003946 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 1052684003947 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1052684003948 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684003949 intersubunit interface [polypeptide binding]; other site 1052684003950 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1052684003951 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1052684003952 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1052684003953 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684003954 dimer interface [polypeptide binding]; other site 1052684003955 ABC-ATPase subunit interface; other site 1052684003956 putative PBP binding regions; other site 1052684003957 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1052684003958 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684003959 ABC-ATPase subunit interface; other site 1052684003960 dimer interface [polypeptide binding]; other site 1052684003961 putative PBP binding regions; other site 1052684003962 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1052684003963 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1052684003964 Ligand Binding Site [chemical binding]; other site 1052684003965 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1052684003966 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1052684003967 Ligand Binding Site [chemical binding]; other site 1052684003968 AAA domain; Region: AAA_31; pfam13614 1052684003969 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1052684003970 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 1052684003971 ATP binding site [chemical binding]; other site 1052684003972 Walker A motif; other site 1052684003973 hexamer interface [polypeptide binding]; other site 1052684003974 Walker B motif; other site 1052684003975 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1052684003976 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 1052684003977 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 1052684003978 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 1052684003979 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1052684003980 phosphopeptide binding site; other site 1052684003981 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1052684003982 TIGR01777 family protein; Region: yfcH 1052684003983 putative NAD(P) binding site [chemical binding]; other site 1052684003984 putative active site [active] 1052684003985 endonuclease IV; Provisional; Region: PRK01060 1052684003986 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1052684003987 AP (apurinic/apyrimidinic) site pocket; other site 1052684003988 DNA interaction; other site 1052684003989 Metal-binding active site; metal-binding site 1052684003990 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1052684003991 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1052684003992 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1052684003993 putative active site [active] 1052684003994 putative substrate binding site [chemical binding]; other site 1052684003995 putative cosubstrate binding site; other site 1052684003996 catalytic site [active] 1052684003997 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1052684003998 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1052684003999 TPP-binding site [chemical binding]; other site 1052684004000 dimer interface [polypeptide binding]; other site 1052684004001 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1052684004002 PYR/PP interface [polypeptide binding]; other site 1052684004003 dimer interface [polypeptide binding]; other site 1052684004004 TPP binding site [chemical binding]; other site 1052684004005 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052684004006 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 1052684004007 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1052684004008 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1052684004009 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1052684004010 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1052684004011 active site 1052684004012 dimer interface [polypeptide binding]; other site 1052684004013 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1052684004014 dimer interface [polypeptide binding]; other site 1052684004015 active site 1052684004016 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1052684004017 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1052684004018 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1052684004019 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684004020 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684004021 WHG domain; Region: WHG; pfam13305 1052684004022 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1052684004023 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1052684004024 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1052684004025 Walker A/P-loop; other site 1052684004026 ATP binding site [chemical binding]; other site 1052684004027 Q-loop/lid; other site 1052684004028 ABC transporter signature motif; other site 1052684004029 Walker B; other site 1052684004030 D-loop; other site 1052684004031 H-loop/switch region; other site 1052684004032 TOBE domain; Region: TOBE_2; pfam08402 1052684004033 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052684004034 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052684004035 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684004036 DNA-binding site [nucleotide binding]; DNA binding site 1052684004037 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684004038 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684004039 homodimer interface [polypeptide binding]; other site 1052684004040 catalytic residue [active] 1052684004041 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1052684004042 EamA-like transporter family; Region: EamA; pfam00892 1052684004043 EamA-like transporter family; Region: EamA; pfam00892 1052684004044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684004045 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052684004046 active site 1052684004047 motif I; other site 1052684004048 motif II; other site 1052684004049 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684004050 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1052684004051 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1052684004052 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1052684004053 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 1052684004054 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684004055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684004056 homodimer interface [polypeptide binding]; other site 1052684004057 catalytic residue [active] 1052684004058 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 1052684004059 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1052684004060 catalytic core [active] 1052684004061 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684004062 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1052684004063 cobalamin binding residues [chemical binding]; other site 1052684004064 putative BtuC binding residues; other site 1052684004065 dimer interface [polypeptide binding]; other site 1052684004066 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052684004067 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684004068 ABC-ATPase subunit interface; other site 1052684004069 dimer interface [polypeptide binding]; other site 1052684004070 putative PBP binding regions; other site 1052684004071 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052684004072 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052684004073 Walker A/P-loop; other site 1052684004074 ATP binding site [chemical binding]; other site 1052684004075 Q-loop/lid; other site 1052684004076 ABC transporter signature motif; other site 1052684004077 Walker B; other site 1052684004078 D-loop; other site 1052684004079 H-loop/switch region; other site 1052684004080 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1052684004081 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1052684004082 putative dimer interface [polypeptide binding]; other site 1052684004083 active site pocket [active] 1052684004084 putative cataytic base [active] 1052684004085 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1052684004086 homotrimer interface [polypeptide binding]; other site 1052684004087 Walker A motif; other site 1052684004088 GTP binding site [chemical binding]; other site 1052684004089 Walker B motif; other site 1052684004090 cobalamin synthase; Reviewed; Region: cobS; PRK00235 1052684004091 cobyric acid synthase; Provisional; Region: PRK00784 1052684004092 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1052684004093 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1052684004094 catalytic triad [active] 1052684004095 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684004096 dimerization interface [polypeptide binding]; other site 1052684004097 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684004098 dimer interface [polypeptide binding]; other site 1052684004099 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 1052684004100 putative CheW interface [polypeptide binding]; other site 1052684004101 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684004102 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1052684004103 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052684004104 CAT RNA binding domain; Region: CAT_RBD; smart01061 1052684004105 PRD domain; Region: PRD; pfam00874 1052684004106 PRD domain; Region: PRD; pfam00874 1052684004107 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052684004108 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052684004109 active site turn [active] 1052684004110 phosphorylation site [posttranslational modification] 1052684004111 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684004112 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052684004113 HPr interaction site; other site 1052684004114 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052684004115 active site 1052684004116 phosphorylation site [posttranslational modification] 1052684004117 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1052684004118 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1052684004119 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 1052684004120 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1052684004121 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1052684004122 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1052684004123 active site 1052684004124 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052684004125 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052684004126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684004127 Coenzyme A binding pocket [chemical binding]; other site 1052684004128 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1052684004129 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1052684004130 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1052684004131 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1052684004132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684004133 motif II; other site 1052684004134 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052684004135 active site 1052684004136 ATP binding site [chemical binding]; other site 1052684004137 substrate binding site [chemical binding]; other site 1052684004138 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1052684004139 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1052684004140 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052684004141 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1052684004142 putative NAD(P) binding site [chemical binding]; other site 1052684004143 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1052684004144 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 1052684004145 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1052684004146 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1052684004147 active site 1052684004148 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1052684004149 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052684004150 ATP binding site [chemical binding]; other site 1052684004151 putative Mg++ binding site [ion binding]; other site 1052684004152 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684004153 nucleotide binding region [chemical binding]; other site 1052684004154 ATP-binding site [chemical binding]; other site 1052684004155 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1052684004156 HRDC domain; Region: HRDC; pfam00570 1052684004157 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 1052684004158 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1052684004159 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 1052684004160 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1052684004161 dimer interface [polypeptide binding]; other site 1052684004162 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1052684004163 active site 1052684004164 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1052684004165 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1052684004166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684004167 S-adenosylmethionine binding site [chemical binding]; other site 1052684004168 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684004169 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684004170 Coenzyme A binding pocket [chemical binding]; other site 1052684004171 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1052684004172 putative active site [active] 1052684004173 nucleotide binding site [chemical binding]; other site 1052684004174 nudix motif; other site 1052684004175 putative metal binding site [ion binding]; other site 1052684004176 Predicted acetyltransferase [General function prediction only]; Region: COG3981 1052684004177 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052684004178 Coenzyme A binding pocket [chemical binding]; other site 1052684004179 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1052684004180 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052684004181 HEAT repeats; Region: HEAT_2; pfam13646 1052684004182 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1052684004183 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052684004184 Zn2+ binding site [ion binding]; other site 1052684004185 Mg2+ binding site [ion binding]; other site 1052684004186 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684004187 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684004188 intersubunit interface [polypeptide binding]; other site 1052684004189 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1052684004190 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684004191 ABC-ATPase subunit interface; other site 1052684004192 dimer interface [polypeptide binding]; other site 1052684004193 putative PBP binding regions; other site 1052684004194 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052684004195 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684004196 ABC-ATPase subunit interface; other site 1052684004197 dimer interface [polypeptide binding]; other site 1052684004198 putative PBP binding regions; other site 1052684004199 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1052684004200 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052684004201 SPFH domain / Band 7 family; Region: Band_7; pfam01145 1052684004202 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1052684004203 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1052684004204 GAF domain; Region: GAF; cl17456 1052684004205 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052684004206 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052684004207 DNA binding residues [nucleotide binding] 1052684004208 dimerization interface [polypeptide binding]; other site 1052684004209 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1052684004210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684004211 S-adenosylmethionine binding site [chemical binding]; other site 1052684004212 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1052684004213 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1052684004214 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1052684004215 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684004216 motif II; other site 1052684004217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052684004218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052684004219 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052684004220 active site 1052684004221 catalytic triad [active] 1052684004222 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684004223 S-adenosylmethionine binding site [chemical binding]; other site 1052684004224 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052684004225 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052684004226 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 1052684004227 GIY-YIG motif/motif A; other site 1052684004228 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 1052684004229 HEAT repeats; Region: HEAT_2; pfam13646 1052684004230 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 1052684004231 RNAase interaction site [polypeptide binding]; other site 1052684004232 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052684004233 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684004234 putative substrate translocation pore; other site 1052684004235 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1052684004236 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1052684004237 TPP-binding site [chemical binding]; other site 1052684004238 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1052684004239 dimer interface [polypeptide binding]; other site 1052684004240 PYR/PP interface [polypeptide binding]; other site 1052684004241 TPP binding site [chemical binding]; other site 1052684004242 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1052684004243 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052684004244 E3 interaction surface; other site 1052684004245 lipoyl attachment site [posttranslational modification]; other site 1052684004246 e3 binding domain; Region: E3_binding; pfam02817 1052684004247 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1052684004248 metal-dependent hydrolase; Provisional; Region: PRK13291 1052684004249 DinB superfamily; Region: DinB_2; pfam12867 1052684004250 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1052684004251 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1052684004252 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1052684004253 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1052684004254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684004255 S-adenosylmethionine binding site [chemical binding]; other site 1052684004256 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1052684004257 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684004258 S-adenosylmethionine binding site [chemical binding]; other site 1052684004259 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1052684004260 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1052684004261 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052684004262 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 1052684004263 active site 1052684004264 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1052684004265 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1052684004266 DXD motif; other site 1052684004267 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1052684004268 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1052684004269 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1052684004270 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1052684004271 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1052684004272 23S rRNA binding site [nucleotide binding]; other site 1052684004273 L21 binding site [polypeptide binding]; other site 1052684004274 L13 binding site [polypeptide binding]; other site 1052684004275 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1052684004276 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1052684004277 ligand binding site [chemical binding]; other site 1052684004278 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1052684004279 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684004280 Walker A/P-loop; other site 1052684004281 ATP binding site [chemical binding]; other site 1052684004282 Q-loop/lid; other site 1052684004283 ABC transporter signature motif; other site 1052684004284 Walker B; other site 1052684004285 D-loop; other site 1052684004286 H-loop/switch region; other site 1052684004287 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1052684004288 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1052684004289 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1052684004290 TM-ABC transporter signature motif; other site 1052684004291 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1052684004292 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1052684004293 TM-ABC transporter signature motif; other site 1052684004294 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684004295 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684004296 Coenzyme A binding pocket [chemical binding]; other site 1052684004297 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 1052684004298 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052684004299 PYR/PP interface [polypeptide binding]; other site 1052684004300 dimer interface [polypeptide binding]; other site 1052684004301 TPP binding site [chemical binding]; other site 1052684004302 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1052684004303 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1052684004304 TPP-binding site [chemical binding]; other site 1052684004305 dimer interface [polypeptide binding]; other site 1052684004306 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1052684004307 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1052684004308 putative valine binding site [chemical binding]; other site 1052684004309 dimer interface [polypeptide binding]; other site 1052684004310 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1052684004311 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1052684004312 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1052684004313 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1052684004314 2-isopropylmalate synthase; Validated; Region: PRK00915 1052684004315 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1052684004316 active site 1052684004317 catalytic residues [active] 1052684004318 metal binding site [ion binding]; metal-binding site 1052684004319 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1052684004320 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1052684004321 tartrate dehydrogenase; Region: TTC; TIGR02089 1052684004322 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1052684004323 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1052684004324 dimer interface [polypeptide binding]; other site 1052684004325 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1052684004326 catalytic triad [active] 1052684004327 peroxidatic and resolving cysteines [active] 1052684004328 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052684004329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684004330 putative active site [active] 1052684004331 heme pocket [chemical binding]; other site 1052684004332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684004333 dimer interface [polypeptide binding]; other site 1052684004334 phosphorylation site [posttranslational modification] 1052684004335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684004336 ATP binding site [chemical binding]; other site 1052684004337 Mg2+ binding site [ion binding]; other site 1052684004338 G-X-G motif; other site 1052684004339 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052684004340 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052684004341 metal binding site [ion binding]; metal-binding site 1052684004342 active site 1052684004343 I-site; other site 1052684004344 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1052684004345 Pectate lyase [Carbohydrate transport and metabolism]; Region: PelB; COG3866 1052684004346 Pectate lyase; Region: Pec_lyase_C; cl01593 1052684004347 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052684004348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684004349 Walker A/P-loop; other site 1052684004350 ATP binding site [chemical binding]; other site 1052684004351 Q-loop/lid; other site 1052684004352 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052684004353 ABC transporter signature motif; other site 1052684004354 Walker B; other site 1052684004355 D-loop; other site 1052684004356 ABC transporter; Region: ABC_tran_2; pfam12848 1052684004357 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052684004358 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1052684004359 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1052684004360 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1052684004361 dimer interface [polypeptide binding]; other site 1052684004362 motif 1; other site 1052684004363 active site 1052684004364 motif 2; other site 1052684004365 motif 3; other site 1052684004366 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1052684004367 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1052684004368 putative tRNA-binding site [nucleotide binding]; other site 1052684004369 B3/4 domain; Region: B3_4; pfam03483 1052684004370 tRNA synthetase B5 domain; Region: B5; smart00874 1052684004371 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1052684004372 dimer interface [polypeptide binding]; other site 1052684004373 motif 1; other site 1052684004374 motif 3; other site 1052684004375 motif 2; other site 1052684004376 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 1052684004377 Cell division protein ZapA; Region: ZapA; cl01146 1052684004378 Membrane protein of unknown function; Region: DUF360; pfam04020 1052684004379 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1052684004380 MutS domain III; Region: MutS_III; pfam05192 1052684004381 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1052684004382 Walker A/P-loop; other site 1052684004383 ATP binding site [chemical binding]; other site 1052684004384 Q-loop/lid; other site 1052684004385 ABC transporter signature motif; other site 1052684004386 Walker B; other site 1052684004387 D-loop; other site 1052684004388 H-loop/switch region; other site 1052684004389 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1052684004390 Smr domain; Region: Smr; pfam01713 1052684004391 Predicted membrane protein [Function unknown]; Region: COG3766 1052684004392 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1052684004393 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1052684004394 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684004395 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684004396 putative substrate translocation pore; other site 1052684004397 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1052684004398 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1052684004399 Coat F domain; Region: Coat_F; pfam07875 1052684004400 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1052684004401 AsnC family; Region: AsnC_trans_reg; pfam01037 1052684004402 hypothetical protein; Validated; Region: PRK07682 1052684004403 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684004404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684004405 homodimer interface [polypeptide binding]; other site 1052684004406 catalytic residue [active] 1052684004407 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052684004408 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1052684004409 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1052684004410 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052684004411 RNA binding surface [nucleotide binding]; other site 1052684004412 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1052684004413 active site 1052684004414 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1052684004415 ArsC family; Region: ArsC; pfam03960 1052684004416 putative ArsC-like catalytic residues; other site 1052684004417 putative TRX-like catalytic residues [active] 1052684004418 5'-3' exonuclease; Region: 53EXOc; smart00475 1052684004419 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1052684004420 active site 1052684004421 metal binding site 1 [ion binding]; metal-binding site 1052684004422 putative 5' ssDNA interaction site; other site 1052684004423 metal binding site 3; metal-binding site 1052684004424 metal binding site 2 [ion binding]; metal-binding site 1052684004425 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1052684004426 putative DNA binding site [nucleotide binding]; other site 1052684004427 putative metal binding site [ion binding]; other site 1052684004428 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1052684004429 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052684004430 nucleotide binding site [chemical binding]; other site 1052684004431 HRDC domain; Region: HRDC; pfam00570 1052684004432 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1052684004433 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 1052684004434 oligomer interface [polypeptide binding]; other site 1052684004435 metal binding site [ion binding]; metal-binding site 1052684004436 metal binding site [ion binding]; metal-binding site 1052684004437 putative Cl binding site [ion binding]; other site 1052684004438 aspartate ring; other site 1052684004439 basic sphincter; other site 1052684004440 hydrophobic gate; other site 1052684004441 periplasmic entrance; other site 1052684004442 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1052684004443 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1052684004444 proposed active site lysine [active] 1052684004445 conserved cys residue [active] 1052684004446 cystathionine gamma-synthase; Reviewed; Region: PRK08247 1052684004447 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052684004448 homodimer interface [polypeptide binding]; other site 1052684004449 substrate-cofactor binding pocket; other site 1052684004450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684004451 catalytic residue [active] 1052684004452 cystathionine beta-lyase; Provisional; Region: PRK08064 1052684004453 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052684004454 homodimer interface [polypeptide binding]; other site 1052684004455 substrate-cofactor binding pocket; other site 1052684004456 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684004457 catalytic residue [active] 1052684004458 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 1052684004459 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684004460 FeS/SAM binding site; other site 1052684004461 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052684004462 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052684004463 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1052684004464 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1052684004465 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 1052684004466 TrkA-C domain; Region: TrkA_C; pfam02080 1052684004467 YtxC-like family; Region: YtxC; pfam08812 1052684004468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 1052684004469 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1052684004470 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052684004471 protein binding site [polypeptide binding]; other site 1052684004472 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684004473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684004474 active site 1052684004475 phosphorylation site [posttranslational modification] 1052684004476 intermolecular recognition site; other site 1052684004477 dimerization interface [polypeptide binding]; other site 1052684004478 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684004479 DNA binding site [nucleotide binding] 1052684004480 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684004481 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684004482 dimerization interface [polypeptide binding]; other site 1052684004483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684004484 dimer interface [polypeptide binding]; other site 1052684004485 phosphorylation site [posttranslational modification] 1052684004486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684004487 ATP binding site [chemical binding]; other site 1052684004488 Mg2+ binding site [ion binding]; other site 1052684004489 G-X-G motif; other site 1052684004490 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1052684004491 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1052684004492 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1052684004493 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 1052684004494 glutamine synthetase, type I; Region: GlnA; TIGR00653 1052684004495 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1052684004496 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1052684004497 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1052684004498 homodimer interface [polypeptide binding]; other site 1052684004499 substrate-cofactor binding pocket; other site 1052684004500 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684004501 catalytic residue [active] 1052684004502 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1052684004503 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1052684004504 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1052684004505 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052684004506 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684004507 active site 1052684004508 phosphorylation site [posttranslational modification] 1052684004509 intermolecular recognition site; other site 1052684004510 dimerization interface [polypeptide binding]; other site 1052684004511 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052684004512 DNA binding residues [nucleotide binding] 1052684004513 dimerization interface [polypeptide binding]; other site 1052684004514 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684004515 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 1052684004516 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684004517 homodimer interface [polypeptide binding]; other site 1052684004518 catalytic residue [active] 1052684004519 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 1052684004520 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 1052684004521 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1052684004522 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1052684004523 heme-binding site [chemical binding]; other site 1052684004524 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684004525 putative CheW interface [polypeptide binding]; other site 1052684004526 N-acetyltransferase; Region: Acetyltransf_2; cl00949 1052684004527 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 1052684004528 Phosphotransferase enzyme family; Region: APH; pfam01636 1052684004529 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1052684004530 active site 1052684004531 ATP binding site [chemical binding]; other site 1052684004532 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052684004533 Predicted membrane protein [Function unknown]; Region: COG3212 1052684004534 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052684004535 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1052684004536 Predicted membrane protein [Function unknown]; Region: COG3212 1052684004537 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 1052684004538 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684004539 HAMP domain; Region: HAMP; pfam00672 1052684004540 dimerization interface [polypeptide binding]; other site 1052684004541 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684004542 dimer interface [polypeptide binding]; other site 1052684004543 phosphorylation site [posttranslational modification] 1052684004544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684004545 Mg2+ binding site [ion binding]; other site 1052684004546 G-X-G motif; other site 1052684004547 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684004548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684004549 active site 1052684004550 phosphorylation site [posttranslational modification] 1052684004551 intermolecular recognition site; other site 1052684004552 dimerization interface [polypeptide binding]; other site 1052684004553 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684004554 DNA binding site [nucleotide binding] 1052684004555 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684004556 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684004557 active site 1052684004558 phosphorylation site [posttranslational modification] 1052684004559 intermolecular recognition site; other site 1052684004560 dimerization interface [polypeptide binding]; other site 1052684004561 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684004562 DNA binding site [nucleotide binding] 1052684004563 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684004564 HAMP domain; Region: HAMP; pfam00672 1052684004565 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684004566 dimer interface [polypeptide binding]; other site 1052684004567 phosphorylation site [posttranslational modification] 1052684004568 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684004569 ATP binding site [chemical binding]; other site 1052684004570 Mg2+ binding site [ion binding]; other site 1052684004571 G-X-G motif; other site 1052684004572 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1052684004573 SpoVR like protein; Region: SpoVR; pfam04293 1052684004574 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1052684004575 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 1052684004576 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684004577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684004578 active site 1052684004579 phosphorylation site [posttranslational modification] 1052684004580 intermolecular recognition site; other site 1052684004581 dimerization interface [polypeptide binding]; other site 1052684004582 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684004583 DNA binding site [nucleotide binding] 1052684004584 Protein of unknown function (DUF805); Region: DUF805; cl01224 1052684004585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684004586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684004587 dimer interface [polypeptide binding]; other site 1052684004588 phosphorylation site [posttranslational modification] 1052684004589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684004590 ATP binding site [chemical binding]; other site 1052684004591 Mg2+ binding site [ion binding]; other site 1052684004592 G-X-G motif; other site 1052684004593 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052684004594 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1052684004595 Walker A/P-loop; other site 1052684004596 ATP binding site [chemical binding]; other site 1052684004597 Q-loop/lid; other site 1052684004598 ABC transporter signature motif; other site 1052684004599 Walker B; other site 1052684004600 D-loop; other site 1052684004601 H-loop/switch region; other site 1052684004602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1052684004603 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052684004604 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1052684004605 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052684004606 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1052684004607 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1052684004608 active site 1052684004609 zinc binding site [ion binding]; other site 1052684004610 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 1052684004611 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 1052684004612 active site 1052684004613 zinc binding site [ion binding]; other site 1052684004614 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684004615 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684004616 DNA binding site [nucleotide binding] 1052684004617 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 1052684004618 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 1052684004619 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 1052684004620 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684004621 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684004622 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684004623 Walker A/P-loop; other site 1052684004624 ATP binding site [chemical binding]; other site 1052684004625 Q-loop/lid; other site 1052684004626 ABC transporter signature motif; other site 1052684004627 Walker B; other site 1052684004628 D-loop; other site 1052684004629 H-loop/switch region; other site 1052684004630 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1052684004631 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1052684004632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684004633 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684004634 putative substrate translocation pore; other site 1052684004635 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1052684004636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684004637 non-specific DNA binding site [nucleotide binding]; other site 1052684004638 salt bridge; other site 1052684004639 sequence-specific DNA binding site [nucleotide binding]; other site 1052684004640 Cupin domain; Region: Cupin_2; pfam07883 1052684004641 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1052684004642 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 1052684004643 active site 1052684004644 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1052684004645 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1052684004646 putative sugar binding sites [chemical binding]; other site 1052684004647 Q-X-W motif; other site 1052684004648 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1052684004649 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 1052684004650 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 1052684004651 active site 1052684004652 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052684004653 S-layer homology domain; Region: SLH; pfam00395 1052684004654 S-layer homology domain; Region: SLH; pfam00395 1052684004655 S-layer homology domain; Region: SLH; pfam00395 1052684004656 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1052684004657 active site 1052684004658 EDD domain protein, DegV family; Region: DegV; TIGR00762 1052684004659 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1052684004660 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1052684004661 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1052684004662 active site 1052684004663 NTP binding site [chemical binding]; other site 1052684004664 metal binding triad [ion binding]; metal-binding site 1052684004665 KNTase C-terminal domain; Region: KNTase_C; pfam07827 1052684004666 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1052684004667 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684004668 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684004669 DNA binding residues [nucleotide binding] 1052684004670 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1052684004671 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1052684004672 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1052684004673 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 1052684004674 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052684004675 siderophore binding site; other site 1052684004676 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052684004677 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684004678 ABC-ATPase subunit interface; other site 1052684004679 dimer interface [polypeptide binding]; other site 1052684004680 putative PBP binding regions; other site 1052684004681 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684004682 ABC-ATPase subunit interface; other site 1052684004683 dimer interface [polypeptide binding]; other site 1052684004684 putative PBP binding regions; other site 1052684004685 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684004686 putative DNA binding site [nucleotide binding]; other site 1052684004687 dimerization interface [polypeptide binding]; other site 1052684004688 putative Zn2+ binding site [ion binding]; other site 1052684004689 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052684004690 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684004691 putative substrate translocation pore; other site 1052684004692 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1052684004693 active site 1052684004694 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684004695 Coenzyme A binding pocket [chemical binding]; other site 1052684004696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684004697 non-specific DNA binding site [nucleotide binding]; other site 1052684004698 salt bridge; other site 1052684004699 sequence-specific DNA binding site [nucleotide binding]; other site 1052684004700 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1052684004701 non-specific DNA binding site [nucleotide binding]; other site 1052684004702 salt bridge; other site 1052684004703 sequence-specific DNA binding site [nucleotide binding]; other site 1052684004704 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684004705 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 1052684004706 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1052684004707 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684004708 nucleotide binding region [chemical binding]; other site 1052684004709 ATP-binding site [chemical binding]; other site 1052684004710 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684004711 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 1052684004712 Restriction endonuclease; Region: Mrr_cat; pfam04471 1052684004713 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1052684004714 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1052684004715 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1052684004716 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 1052684004717 Putative amidase domain; Region: Amidase_6; pfam12671 1052684004718 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1052684004719 Protein with unknown function (DUF469); Region: DUF469; cl01237 1052684004720 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1052684004721 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1052684004722 catalytic residues [active] 1052684004723 catalytic nucleophile [active] 1052684004724 Presynaptic Site I dimer interface [polypeptide binding]; other site 1052684004725 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1052684004726 Synaptic Flat tetramer interface [polypeptide binding]; other site 1052684004727 Synaptic Site I dimer interface [polypeptide binding]; other site 1052684004728 DNA binding site [nucleotide binding] 1052684004729 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684004730 non-specific DNA binding site [nucleotide binding]; other site 1052684004731 salt bridge; other site 1052684004732 sequence-specific DNA binding site [nucleotide binding]; other site 1052684004733 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1052684004734 Pyocin large subunit [General function prediction only]; Region: COG5529 1052684004735 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 1052684004736 active site 1052684004737 catalytic site [active] 1052684004738 substrate binding site [chemical binding]; other site 1052684004739 amidase; Provisional; Region: PRK06828 1052684004740 Amidase; Region: Amidase; cl11426 1052684004741 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684004742 Protein with unknown function (DUF469); Region: DUF469; cl01237 1052684004743 UPF0489 domain; Region: UPF0489; pfam12640 1052684004744 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1052684004745 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1052684004746 catalytic residues [active] 1052684004747 catalytic nucleophile [active] 1052684004748 Presynaptic Site I dimer interface [polypeptide binding]; other site 1052684004749 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1052684004750 Synaptic Flat tetramer interface [polypeptide binding]; other site 1052684004751 Synaptic Site I dimer interface [polypeptide binding]; other site 1052684004752 DNA binding site [nucleotide binding] 1052684004753 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684004754 non-specific DNA binding site [nucleotide binding]; other site 1052684004755 salt bridge; other site 1052684004756 sequence-specific DNA binding site [nucleotide binding]; other site 1052684004757 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1052684004758 putative active site [active] 1052684004759 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 1052684004760 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1052684004761 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1052684004762 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 1052684004763 Transposase; Region: HTH_Tnp_1; cl17663 1052684004764 putative transposase OrfB; Reviewed; Region: PHA02517 1052684004765 HTH-like domain; Region: HTH_21; pfam13276 1052684004766 Integrase core domain; Region: rve; pfam00665 1052684004767 Integrase core domain; Region: rve_3; pfam13683 1052684004768 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1052684004769 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1052684004770 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1052684004771 Phosphotransferase enzyme family; Region: APH; pfam01636 1052684004772 Ferritin-like domain; Region: Ferritin; pfam00210 1052684004773 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1052684004774 dimerization interface [polypeptide binding]; other site 1052684004775 DPS ferroxidase diiron center [ion binding]; other site 1052684004776 ion pore; other site 1052684004777 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1052684004778 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1052684004779 Walker A/P-loop; other site 1052684004780 ATP binding site [chemical binding]; other site 1052684004781 Q-loop/lid; other site 1052684004782 ABC transporter signature motif; other site 1052684004783 Walker B; other site 1052684004784 D-loop; other site 1052684004785 H-loop/switch region; other site 1052684004786 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1052684004787 FeS assembly protein SufD; Region: sufD; TIGR01981 1052684004788 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1052684004789 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1052684004790 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052684004791 catalytic residue [active] 1052684004792 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1052684004793 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1052684004794 trimerization site [polypeptide binding]; other site 1052684004795 active site 1052684004796 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1052684004797 FeS assembly protein SufB; Region: sufB; TIGR01980 1052684004798 Transposase; Region: HTH_Tnp_1; cl17663 1052684004799 putative transposase OrfB; Reviewed; Region: PHA02517 1052684004800 HTH-like domain; Region: HTH_21; pfam13276 1052684004801 Integrase core domain; Region: rve; pfam00665 1052684004802 Integrase core domain; Region: rve_3; pfam13683 1052684004803 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1052684004804 CAAX protease self-immunity; Region: Abi; pfam02517 1052684004805 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684004806 non-specific DNA binding site [nucleotide binding]; other site 1052684004807 salt bridge; other site 1052684004808 sequence-specific DNA binding site [nucleotide binding]; other site 1052684004809 YmaF family; Region: YmaF; pfam12788 1052684004810 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052684004811 dimanganese center [ion binding]; other site 1052684004812 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052684004813 dimanganese center [ion binding]; other site 1052684004814 putative transposase OrfB; Reviewed; Region: PHA02517 1052684004815 HTH-like domain; Region: HTH_21; pfam13276 1052684004816 Integrase core domain; Region: rve; pfam00665 1052684004817 Integrase core domain; Region: rve_2; pfam13333 1052684004818 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1052684004819 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052684004820 Zn2+ binding site [ion binding]; other site 1052684004821 Mg2+ binding site [ion binding]; other site 1052684004822 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 1052684004823 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 1052684004824 active site 1052684004825 metal binding site [ion binding]; metal-binding site 1052684004826 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052684004827 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1052684004828 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052684004829 Zn2+ binding site [ion binding]; other site 1052684004830 Mg2+ binding site [ion binding]; other site 1052684004831 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1052684004832 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684004833 FeS/SAM binding site; other site 1052684004834 YfkB-like domain; Region: YfkB; pfam08756 1052684004835 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052684004836 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052684004837 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052684004838 Transporter associated domain; Region: CorC_HlyC; smart01091 1052684004839 CotJB protein; Region: CotJB; pfam12652 1052684004840 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1052684004841 dimanganese center [ion binding]; other site 1052684004842 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052684004843 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684004844 DNA-binding site [nucleotide binding]; DNA binding site 1052684004845 UTRA domain; Region: UTRA; pfam07702 1052684004846 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 1052684004847 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 1052684004848 putative active site [active] 1052684004849 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1052684004850 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1052684004851 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052684004852 substrate binding site [chemical binding]; other site 1052684004853 ATP binding site [chemical binding]; other site 1052684004854 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1052684004855 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1052684004856 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052684004857 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1052684004858 Metal-binding active site; metal-binding site 1052684004859 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052684004860 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1052684004861 putative metal binding site; other site 1052684004862 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052684004863 binding surface 1052684004864 TPR motif; other site 1052684004865 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1052684004866 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052684004867 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052684004868 active site 1052684004869 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1052684004870 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1052684004871 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052684004872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684004873 S-adenosylmethionine binding site [chemical binding]; other site 1052684004874 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1052684004875 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684004876 motif II; other site 1052684004877 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 1052684004878 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1052684004879 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1052684004880 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1052684004881 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1052684004882 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1052684004883 hypothetical protein; Provisional; Region: PRK13676 1052684004884 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1052684004885 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684004886 DNA-binding site [nucleotide binding]; DNA binding site 1052684004887 DRTGG domain; Region: DRTGG; pfam07085 1052684004888 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1052684004889 Thioesterase superfamily; Region: 4HBT; pfam03061 1052684004890 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 1052684004891 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 1052684004892 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1052684004893 active site 1052684004894 PHP Thumb interface [polypeptide binding]; other site 1052684004895 metal binding site [ion binding]; metal-binding site 1052684004896 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1052684004897 generic binding surface II; other site 1052684004898 generic binding surface I; other site 1052684004899 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1052684004900 tetramer interfaces [polypeptide binding]; other site 1052684004901 binuclear metal-binding site [ion binding]; other site 1052684004902 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1052684004903 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 1052684004904 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1052684004905 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1052684004906 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1052684004907 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1052684004908 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1052684004909 domain interfaces; other site 1052684004910 active site 1052684004911 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684004912 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684004913 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1052684004914 dimerization interface [polypeptide binding]; other site 1052684004915 PBP superfamily domain; Region: PBP_like_2; cl17296 1052684004916 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1052684004917 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1052684004918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684004919 dimer interface [polypeptide binding]; other site 1052684004920 conserved gate region; other site 1052684004921 putative PBP binding loops; other site 1052684004922 ABC-ATPase subunit interface; other site 1052684004923 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1052684004924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684004925 dimer interface [polypeptide binding]; other site 1052684004926 conserved gate region; other site 1052684004927 putative PBP binding loops; other site 1052684004928 ABC-ATPase subunit interface; other site 1052684004929 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1052684004930 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1052684004931 Walker A/P-loop; other site 1052684004932 ATP binding site [chemical binding]; other site 1052684004933 Q-loop/lid; other site 1052684004934 ABC transporter signature motif; other site 1052684004935 Walker B; other site 1052684004936 D-loop; other site 1052684004937 H-loop/switch region; other site 1052684004938 Pectic acid lyase; Region: Pec_lyase; pfam09492 1052684004939 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1052684004940 active site 1052684004941 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 1052684004942 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1052684004943 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052684004944 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1052684004945 Citrate synthase; Region: Citrate_synt; pfam00285 1052684004946 oxalacetate binding site [chemical binding]; other site 1052684004947 citrylCoA binding site [chemical binding]; other site 1052684004948 coenzyme A binding site [chemical binding]; other site 1052684004949 catalytic triad [active] 1052684004950 isocitrate dehydrogenase; Validated; Region: PRK06451 1052684004951 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1052684004952 malate dehydrogenase; Reviewed; Region: PRK06223 1052684004953 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 1052684004954 NAD(P) binding site [chemical binding]; other site 1052684004955 dimer interface [polypeptide binding]; other site 1052684004956 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052684004957 substrate binding site [chemical binding]; other site 1052684004958 short chain dehydrogenase; Provisional; Region: PRK06701 1052684004959 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1052684004960 NAD binding site [chemical binding]; other site 1052684004961 metal binding site [ion binding]; metal-binding site 1052684004962 active site 1052684004963 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1052684004964 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684004965 dimerization interface [polypeptide binding]; other site 1052684004966 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052684004967 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052684004968 putative active site [active] 1052684004969 heme pocket [chemical binding]; other site 1052684004970 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684004971 dimer interface [polypeptide binding]; other site 1052684004972 phosphorylation site [posttranslational modification] 1052684004973 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684004974 ATP binding site [chemical binding]; other site 1052684004975 Mg2+ binding site [ion binding]; other site 1052684004976 G-X-G motif; other site 1052684004977 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684004978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684004979 active site 1052684004980 phosphorylation site [posttranslational modification] 1052684004981 intermolecular recognition site; other site 1052684004982 dimerization interface [polypeptide binding]; other site 1052684004983 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684004984 DNA binding site [nucleotide binding] 1052684004985 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1052684004986 FOG: CBS domain [General function prediction only]; Region: COG0517 1052684004987 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684004988 dimer interface [polypeptide binding]; other site 1052684004989 putative CheW interface [polypeptide binding]; other site 1052684004990 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1052684004991 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1052684004992 Walker A/P-loop; other site 1052684004993 ATP binding site [chemical binding]; other site 1052684004994 Q-loop/lid; other site 1052684004995 ABC transporter signature motif; other site 1052684004996 Walker B; other site 1052684004997 D-loop; other site 1052684004998 H-loop/switch region; other site 1052684004999 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1052684005000 PhoU domain; Region: PhoU; pfam01895 1052684005001 PhoU domain; Region: PhoU; pfam01895 1052684005002 DNA polymerase I; Provisional; Region: PRK05755 1052684005003 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1052684005004 active site 1052684005005 metal binding site 1 [ion binding]; metal-binding site 1052684005006 putative 5' ssDNA interaction site; other site 1052684005007 metal binding site 3; metal-binding site 1052684005008 metal binding site 2 [ion binding]; metal-binding site 1052684005009 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1052684005010 putative DNA binding site [nucleotide binding]; other site 1052684005011 putative metal binding site [ion binding]; other site 1052684005012 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1052684005013 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1052684005014 active site 1052684005015 DNA binding site [nucleotide binding] 1052684005016 catalytic site [active] 1052684005017 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1052684005018 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1052684005019 DNA binding site [nucleotide binding] 1052684005020 catalytic residue [active] 1052684005021 H2TH interface [polypeptide binding]; other site 1052684005022 putative catalytic residues [active] 1052684005023 turnover-facilitating residue; other site 1052684005024 intercalation triad [nucleotide binding]; other site 1052684005025 8OG recognition residue [nucleotide binding]; other site 1052684005026 putative reading head residues; other site 1052684005027 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1052684005028 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1052684005029 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 1052684005030 Domain of unknown function DUF; Region: DUF204; pfam02659 1052684005031 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1052684005032 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1052684005033 CoA-binding site [chemical binding]; other site 1052684005034 ATP-binding [chemical binding]; other site 1052684005035 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1052684005036 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1052684005037 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052684005038 catalytic residue [active] 1052684005039 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052684005040 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1052684005041 ATP cone domain; Region: ATP-cone; pfam03477 1052684005042 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1052684005043 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052684005044 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684005045 Coenzyme A binding pocket [chemical binding]; other site 1052684005046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052684005047 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1052684005048 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052684005049 DNA binding residues [nucleotide binding] 1052684005050 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1052684005051 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684005052 FeS/SAM binding site; other site 1052684005053 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1052684005054 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684005055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684005056 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684005057 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684005058 intersubunit interface [polypeptide binding]; other site 1052684005059 Domain of unknown function (DUF1795); Region: DUF1795; cl02256 1052684005060 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1052684005061 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1052684005062 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1052684005063 ligand binding site [chemical binding]; other site 1052684005064 flexible hinge region; other site 1052684005065 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1052684005066 putative switch regulator; other site 1052684005067 non-specific DNA interactions [nucleotide binding]; other site 1052684005068 DNA binding site [nucleotide binding] 1052684005069 sequence specific DNA binding site [nucleotide binding]; other site 1052684005070 putative cAMP binding site [chemical binding]; other site 1052684005071 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1052684005072 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1052684005073 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1052684005074 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1052684005075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684005076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684005077 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052684005078 dimerization interface [polypeptide binding]; other site 1052684005079 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1052684005080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684005081 S-adenosylmethionine binding site [chemical binding]; other site 1052684005082 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052684005083 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1052684005084 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1052684005085 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1052684005086 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1052684005087 putative substrate binding site [chemical binding]; other site 1052684005088 putative ATP binding site [chemical binding]; other site 1052684005089 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1052684005090 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052684005091 active site 1052684005092 phosphorylation site [posttranslational modification] 1052684005093 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1052684005094 active site 1052684005095 P-loop; other site 1052684005096 phosphorylation site [posttranslational modification] 1052684005097 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1052684005098 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684005099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684005100 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684005101 dimerization interface [polypeptide binding]; other site 1052684005102 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1052684005103 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052684005104 CAT RNA binding domain; Region: CAT_RBD; smart01061 1052684005105 PRD domain; Region: PRD; pfam00874 1052684005106 PRD domain; Region: PRD; pfam00874 1052684005107 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052684005108 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052684005109 active site turn [active] 1052684005110 phosphorylation site [posttranslational modification] 1052684005111 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684005112 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052684005113 HPr interaction site; other site 1052684005114 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052684005115 active site 1052684005116 phosphorylation site [posttranslational modification] 1052684005117 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1052684005118 beta-galactosidase; Region: BGL; TIGR03356 1052684005119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684005120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684005121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684005122 dimerization interface [polypeptide binding]; other site 1052684005123 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1052684005124 substrate binding site [chemical binding]; other site 1052684005125 THF binding site; other site 1052684005126 zinc-binding site [ion binding]; other site 1052684005127 putative transposase OrfB; Reviewed; Region: PHA02517 1052684005128 HTH-like domain; Region: HTH_21; pfam13276 1052684005129 Integrase core domain; Region: rve; pfam00665 1052684005130 Integrase core domain; Region: rve_3; pfam13683 1052684005131 Transposase; Region: HTH_Tnp_1; cl17663 1052684005132 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1052684005133 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1052684005134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684005135 NAD(P) binding site [chemical binding]; other site 1052684005136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684005137 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1052684005138 active site 1052684005139 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052684005140 GAD-like domain; Region: GAD-like; pfam08887 1052684005141 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 1052684005142 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1052684005143 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1052684005144 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1052684005145 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1052684005146 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1052684005147 DNA methylase; Region: N6_N4_Mtase; cl17433 1052684005148 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684005149 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684005150 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1052684005151 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052684005152 DNA binding site [nucleotide binding] 1052684005153 active site 1052684005154 Int/Topo IB signature motif; other site 1052684005155 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 1052684005156 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684005157 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684005158 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1052684005159 YWTD domain; Region: YWTD; cl17223 1052684005160 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 1052684005161 heat shock protein 90; Provisional; Region: PRK05218 1052684005162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684005163 ATP binding site [chemical binding]; other site 1052684005164 Mg2+ binding site [ion binding]; other site 1052684005165 G-X-G motif; other site 1052684005166 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 1052684005167 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1052684005168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684005169 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 1052684005170 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 1052684005171 dimer interface [polypeptide binding]; other site 1052684005172 active site 1052684005173 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052684005174 catalytic residues [active] 1052684005175 substrate binding site [chemical binding]; other site 1052684005176 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1052684005177 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684005178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684005179 Coenzyme A binding pocket [chemical binding]; other site 1052684005180 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1052684005181 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684005182 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684005183 dimerization interface [polypeptide binding]; other site 1052684005184 putative DNA binding site [nucleotide binding]; other site 1052684005185 putative Zn2+ binding site [ion binding]; other site 1052684005186 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1052684005187 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1052684005188 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1052684005189 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1052684005190 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 1052684005191 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1052684005192 active site 1052684005193 metal binding site [ion binding]; metal-binding site 1052684005194 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052684005195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684005196 DNA-binding site [nucleotide binding]; DNA binding site 1052684005197 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1052684005198 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1052684005199 putative dimerization interface [polypeptide binding]; other site 1052684005200 putative ligand binding site [chemical binding]; other site 1052684005201 ribulokinase; Provisional; Region: PRK04123 1052684005202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1052684005203 non-specific DNA binding site [nucleotide binding]; other site 1052684005204 salt bridge; other site 1052684005205 sequence-specific DNA binding site [nucleotide binding]; other site 1052684005206 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684005207 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052684005208 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1052684005209 NodB motif; other site 1052684005210 active site 1052684005211 catalytic site [active] 1052684005212 Zn binding site [ion binding]; other site 1052684005213 Holin family; Region: Phage_holin_4; pfam05105 1052684005214 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1052684005215 Uncharacterized conserved protein [Function unknown]; Region: COG2445 1052684005216 Predicted transcriptional regulator [Transcription]; Region: COG2345 1052684005217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684005218 putative DNA binding site [nucleotide binding]; other site 1052684005219 putative Zn2+ binding site [ion binding]; other site 1052684005220 YtxH-like protein; Region: YtxH; pfam12732 1052684005221 glutamate racemase; Provisional; Region: PRK00865 1052684005222 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052684005223 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052684005224 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 1052684005225 putative active site [active] 1052684005226 Zn binding site [ion binding]; other site 1052684005227 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 1052684005228 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 1052684005229 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1052684005230 Sulfatase; Region: Sulfatase; pfam00884 1052684005231 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1052684005232 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1052684005233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1052684005234 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1052684005235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1052684005236 drug efflux system protein MdtG; Provisional; Region: PRK09874 1052684005237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684005238 putative substrate translocation pore; other site 1052684005239 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 1052684005240 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1052684005241 substrate binding site [chemical binding]; other site 1052684005242 active site 1052684005243 ferrochelatase; Provisional; Region: PRK12435 1052684005244 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1052684005245 C-terminal domain interface [polypeptide binding]; other site 1052684005246 active site 1052684005247 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1052684005248 active site 1052684005249 N-terminal domain interface [polypeptide binding]; other site 1052684005250 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1052684005251 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1052684005252 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 1052684005253 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 1052684005254 putative active site [active] 1052684005255 putative metal binding site [ion binding]; other site 1052684005256 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1052684005257 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1052684005258 active site 1052684005259 catalytic site [active] 1052684005260 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1052684005261 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 1052684005262 Integral membrane protein DUF92; Region: DUF92; pfam01940 1052684005263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684005264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684005265 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052684005266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684005267 Walker A/P-loop; other site 1052684005268 ATP binding site [chemical binding]; other site 1052684005269 Q-loop/lid; other site 1052684005270 ABC transporter signature motif; other site 1052684005271 Walker B; other site 1052684005272 D-loop; other site 1052684005273 H-loop/switch region; other site 1052684005274 ABC transporter; Region: ABC_tran_2; pfam12848 1052684005275 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052684005276 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1052684005277 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1052684005278 putative oligomer interface [polypeptide binding]; other site 1052684005279 putative active site [active] 1052684005280 metal binding site [ion binding]; metal-binding site 1052684005281 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 1052684005282 oligoendopeptidase F; Region: pepF; TIGR00181 1052684005283 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1052684005284 active site 1052684005285 Zn binding site [ion binding]; other site 1052684005286 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1052684005287 DNA-binding site [nucleotide binding]; DNA binding site 1052684005288 RNA-binding motif; other site 1052684005289 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1052684005290 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 1052684005291 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 1052684005292 6-phosphofructokinase; Provisional; Region: PRK03202 1052684005293 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1052684005294 active site 1052684005295 ADP/pyrophosphate binding site [chemical binding]; other site 1052684005296 dimerization interface [polypeptide binding]; other site 1052684005297 allosteric effector site; other site 1052684005298 fructose-1,6-bisphosphate binding site; other site 1052684005299 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 1052684005300 multidrug efflux protein; Reviewed; Region: PRK01766 1052684005301 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1052684005302 cation binding site [ion binding]; other site 1052684005303 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 1052684005304 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052684005305 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052684005306 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052684005307 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052684005308 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 1052684005309 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052684005310 ATP binding site [chemical binding]; other site 1052684005311 Mg++ binding site [ion binding]; other site 1052684005312 motif III; other site 1052684005313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684005314 nucleotide binding region [chemical binding]; other site 1052684005315 ATP-binding site [chemical binding]; other site 1052684005316 Protein of unknown function, DUF624; Region: DUF624; cl02369 1052684005317 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 1052684005318 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1052684005319 dimer interface [polypeptide binding]; other site 1052684005320 catalytic triad [active] 1052684005321 peroxidatic and resolving cysteines [active] 1052684005322 Rhomboid family; Region: Rhomboid; cl11446 1052684005323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684005324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684005325 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 1052684005326 putative dimerization interface [polypeptide binding]; other site 1052684005327 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 1052684005328 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1052684005329 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052684005330 DNA binding residues [nucleotide binding] 1052684005331 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1052684005332 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 1052684005333 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1052684005334 metal binding triad; other site 1052684005335 hypothetical protein; Provisional; Region: PRK07740 1052684005336 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1052684005337 active site 1052684005338 catalytic site [active] 1052684005339 substrate binding site [chemical binding]; other site 1052684005340 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1052684005341 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1052684005342 catalytic residues [active] 1052684005343 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1052684005344 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 1052684005345 active site 1052684005346 catalytic residues [active] 1052684005347 metal binding site [ion binding]; metal-binding site 1052684005348 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1052684005349 DNA polymerase IV; Validated; Region: PRK01810 1052684005350 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1052684005351 active site 1052684005352 DNA binding site [nucleotide binding] 1052684005353 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1052684005354 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1052684005355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1052684005356 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1052684005357 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1052684005358 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1052684005359 quinone interaction residues [chemical binding]; other site 1052684005360 active site 1052684005361 catalytic residues [active] 1052684005362 FMN binding site [chemical binding]; other site 1052684005363 substrate binding site [chemical binding]; other site 1052684005364 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052684005365 synthetase active site [active] 1052684005366 NTP binding site [chemical binding]; other site 1052684005367 metal binding site [ion binding]; metal-binding site 1052684005368 Domain of unknown function (DUF309); Region: DUF309; pfam03745 1052684005369 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052684005370 catalytic residues [active] 1052684005371 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 1052684005372 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 1052684005373 Uncharacterized conserved protein [Function unknown]; Region: COG3270 1052684005374 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1052684005375 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052684005376 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1052684005377 RNA binding surface [nucleotide binding]; other site 1052684005378 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1052684005379 active site 1052684005380 uracil binding [chemical binding]; other site 1052684005381 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052684005382 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052684005383 metal binding site [ion binding]; metal-binding site 1052684005384 active site 1052684005385 I-site; other site 1052684005386 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684005387 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052684005388 Uncharacterized membrane protein [Function unknown]; Region: COG3949 1052684005389 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1052684005390 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052684005391 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052684005392 active site 1052684005393 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1052684005394 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1052684005395 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1052684005396 NodB motif; other site 1052684005397 putative active site [active] 1052684005398 putative catalytic site [active] 1052684005399 Zn binding site [ion binding]; other site 1052684005400 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1052684005401 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052684005402 active site 1052684005403 metal binding site [ion binding]; metal-binding site 1052684005404 YqzE-like protein; Region: YqzE; pfam14038 1052684005405 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 1052684005406 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1052684005407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052684005408 ATP binding site [chemical binding]; other site 1052684005409 putative Mg++ binding site [ion binding]; other site 1052684005410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684005411 nucleotide binding region [chemical binding]; other site 1052684005412 ATP-binding site [chemical binding]; other site 1052684005413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684005414 salt bridge; other site 1052684005415 non-specific DNA binding site [nucleotide binding]; other site 1052684005416 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052684005417 sequence-specific DNA binding site [nucleotide binding]; other site 1052684005418 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1052684005419 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1052684005420 dimer interface [polypeptide binding]; other site 1052684005421 active site 1052684005422 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1052684005423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684005424 Coenzyme A binding pocket [chemical binding]; other site 1052684005425 Predicted transcriptional regulator [Transcription]; Region: COG2378 1052684005426 HTH domain; Region: HTH_11; pfam08279 1052684005427 WYL domain; Region: WYL; pfam13280 1052684005428 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 1052684005429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1052684005430 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052684005431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684005432 putative substrate translocation pore; other site 1052684005433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684005434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684005435 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1052684005436 putative ADP-ribose binding site [chemical binding]; other site 1052684005437 putative active site [active] 1052684005438 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1052684005439 nudix motif; other site 1052684005440 hypothetical protein; Validated; Region: PRK07682 1052684005441 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684005442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684005443 homodimer interface [polypeptide binding]; other site 1052684005444 catalytic residue [active] 1052684005445 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1052684005446 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 1052684005447 Predicted transcriptional regulator [Transcription]; Region: COG4189 1052684005448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684005449 dimerization interface [polypeptide binding]; other site 1052684005450 putative DNA binding site [nucleotide binding]; other site 1052684005451 putative Zn2+ binding site [ion binding]; other site 1052684005452 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684005453 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684005454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684005455 putative PBP binding loops; other site 1052684005456 dimer interface [polypeptide binding]; other site 1052684005457 ABC-ATPase subunit interface; other site 1052684005458 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684005459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684005460 dimer interface [polypeptide binding]; other site 1052684005461 conserved gate region; other site 1052684005462 putative PBP binding loops; other site 1052684005463 ABC-ATPase subunit interface; other site 1052684005464 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1052684005465 substrate binding site [chemical binding]; other site 1052684005466 active site 1052684005467 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1052684005468 active site 1052684005469 hypothetical protein; Provisional; Region: PRK06922 1052684005470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684005471 S-adenosylmethionine binding site [chemical binding]; other site 1052684005472 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1052684005473 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1052684005474 dimer interface [polypeptide binding]; other site 1052684005475 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052684005476 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684005477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684005478 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684005479 putative substrate translocation pore; other site 1052684005480 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1052684005481 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1052684005482 dimer interface [polypeptide binding]; other site 1052684005483 putative radical transfer pathway; other site 1052684005484 diiron center [ion binding]; other site 1052684005485 tyrosyl radical; other site 1052684005486 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 1052684005487 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1052684005488 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1052684005489 active site 1052684005490 dimer interface [polypeptide binding]; other site 1052684005491 catalytic residues [active] 1052684005492 effector binding site; other site 1052684005493 R2 peptide binding site; other site 1052684005494 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1052684005495 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1052684005496 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052684005497 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052684005498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684005499 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684005500 putative substrate translocation pore; other site 1052684005501 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684005502 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684005503 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684005504 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684005505 DNA binding site [nucleotide binding] 1052684005506 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052684005507 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1052684005508 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1052684005509 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1052684005510 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 1052684005511 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 1052684005512 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 1052684005513 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684005514 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1052684005515 Predicted membrane protein [Function unknown]; Region: COG4129 1052684005516 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1052684005517 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1052684005518 Part of AAA domain; Region: AAA_19; pfam13245 1052684005519 Family description; Region: UvrD_C_2; pfam13538 1052684005520 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1052684005521 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052684005522 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1052684005523 active site 1052684005524 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1052684005525 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1052684005526 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1052684005527 ligand binding site [chemical binding]; other site 1052684005528 flexible hinge region; other site 1052684005529 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684005530 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684005531 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684005532 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1052684005533 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684005534 dimerization interface [polypeptide binding]; other site 1052684005535 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684005536 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684005537 dimer interface [polypeptide binding]; other site 1052684005538 putative CheW interface [polypeptide binding]; other site 1052684005539 galactoside permease; Reviewed; Region: lacY; PRK09528 1052684005540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684005541 putative substrate translocation pore; other site 1052684005542 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1052684005543 Cupin domain; Region: Cupin_2; pfam07883 1052684005544 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684005545 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684005546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684005547 putative alpha-glucosidase; Provisional; Region: PRK10658 1052684005548 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1052684005549 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1052684005550 active site 1052684005551 homotrimer interface [polypeptide binding]; other site 1052684005552 catalytic site [active] 1052684005553 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1052684005554 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052684005555 Beta-lactamase; Region: Beta-lactamase; pfam00144 1052684005556 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1052684005557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684005558 dimerization interface [polypeptide binding]; other site 1052684005559 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684005560 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684005561 dimer interface [polypeptide binding]; other site 1052684005562 putative CheW interface [polypeptide binding]; other site 1052684005563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684005564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684005565 putative substrate translocation pore; other site 1052684005566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684005567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684005568 putative substrate translocation pore; other site 1052684005569 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684005570 MarR family; Region: MarR; pfam01047 1052684005571 MarR family; Region: MarR_2; cl17246 1052684005572 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1052684005573 active site 1052684005574 intersubunit interactions; other site 1052684005575 catalytic residue [active] 1052684005576 HTH domain; Region: HTH_11; pfam08279 1052684005577 FOG: CBS domain [General function prediction only]; Region: COG0517 1052684005578 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1052684005579 TraX protein; Region: TraX; pfam05857 1052684005580 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1052684005581 putative active site [active] 1052684005582 putative metal binding site [ion binding]; other site 1052684005583 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684005584 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1052684005585 acyl-activating enzyme (AAE) consensus motif; other site 1052684005586 AMP binding site [chemical binding]; other site 1052684005587 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684005588 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1052684005589 thioester reductase domain; Region: Thioester-redct; TIGR01746 1052684005590 putative NAD(P) binding site [chemical binding]; other site 1052684005591 active site 1052684005592 putative substrate binding site [chemical binding]; other site 1052684005593 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684005594 dimerization interface [polypeptide binding]; other site 1052684005595 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684005596 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684005597 dimer interface [polypeptide binding]; other site 1052684005598 putative CheW interface [polypeptide binding]; other site 1052684005599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684005600 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684005601 Coenzyme A binding pocket [chemical binding]; other site 1052684005602 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1052684005603 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052684005604 active site 1052684005605 dimer interface [polypeptide binding]; other site 1052684005606 VanZ like family; Region: VanZ; pfam04892 1052684005607 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684005608 MarR family; Region: MarR; pfam01047 1052684005609 MarR family; Region: MarR_2; cl17246 1052684005610 B12 binding domain; Region: B12-binding_2; pfam02607 1052684005611 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 1052684005612 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 1052684005613 B12 binding site [chemical binding]; other site 1052684005614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684005615 dimer interface [polypeptide binding]; other site 1052684005616 phosphorylation site [posttranslational modification] 1052684005617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684005618 ATP binding site [chemical binding]; other site 1052684005619 Mg2+ binding site [ion binding]; other site 1052684005620 G-X-G motif; other site 1052684005621 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684005622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684005623 active site 1052684005624 phosphorylation site [posttranslational modification] 1052684005625 intermolecular recognition site; other site 1052684005626 dimerization interface [polypeptide binding]; other site 1052684005627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684005628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684005629 putative substrate translocation pore; other site 1052684005630 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 1052684005631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684005632 Coenzyme A binding pocket [chemical binding]; other site 1052684005633 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1052684005634 active site 1052684005635 oxyanion hole [active] 1052684005636 catalytic triad [active] 1052684005637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052684005638 binding surface 1052684005639 TPR motif; other site 1052684005640 Uncharacterized conserved protein [Function unknown]; Region: COG5646 1052684005641 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052684005642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052684005643 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684005644 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1052684005645 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052684005646 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052684005647 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1052684005648 lactaldehyde reductase; Region: lactal_redase; TIGR02638 1052684005649 dimer interface [polypeptide binding]; other site 1052684005650 active site 1052684005651 metal binding site [ion binding]; metal-binding site 1052684005652 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 1052684005653 homodimer interface [polypeptide binding]; other site 1052684005654 metal binding site [ion binding]; metal-binding site 1052684005655 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684005656 MarR family; Region: MarR_2; pfam12802 1052684005657 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1052684005658 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052684005659 EDD domain protein, DegV family; Region: DegV; TIGR00762 1052684005660 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1052684005661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684005662 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684005663 putative substrate translocation pore; other site 1052684005664 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1052684005665 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1052684005666 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1052684005667 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1052684005668 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684005669 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684005670 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684005671 Amino acid permease; Region: AA_permease_2; pfam13520 1052684005672 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1052684005673 Accessory gene regulator B; Region: AgrB; pfam04647 1052684005674 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1052684005675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684005676 S-adenosylmethionine binding site [chemical binding]; other site 1052684005677 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1052684005678 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1052684005679 active site 1052684005680 (T/H)XGH motif; other site 1052684005681 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1052684005682 Nucleoside recognition; Region: Gate; pfam07670 1052684005683 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1052684005684 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052684005685 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1052684005686 hypothetical protein; Provisional; Region: PRK13670 1052684005687 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 1052684005688 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1052684005689 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1052684005690 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 1052684005691 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 1052684005692 active site 2 [active] 1052684005693 active site 1 [active] 1052684005694 putative phosphate acyltransferase; Provisional; Region: PRK05331 1052684005695 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1052684005696 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1052684005697 dimer interface [polypeptide binding]; other site 1052684005698 active site 1052684005699 CoA binding pocket [chemical binding]; other site 1052684005700 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1052684005701 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052684005702 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1052684005703 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1052684005704 NAD(P) binding site [chemical binding]; other site 1052684005705 homotetramer interface [polypeptide binding]; other site 1052684005706 homodimer interface [polypeptide binding]; other site 1052684005707 active site 1052684005708 acyl carrier protein; Provisional; Region: acpP; PRK00982 1052684005709 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1052684005710 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1052684005711 dimer interface [polypeptide binding]; other site 1052684005712 active site 1052684005713 ribonuclease III; Reviewed; Region: rnc; PRK00102 1052684005714 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1052684005715 dimerization interface [polypeptide binding]; other site 1052684005716 active site 1052684005717 metal binding site [ion binding]; metal-binding site 1052684005718 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1052684005719 dsRNA binding site [nucleotide binding]; other site 1052684005720 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1052684005721 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1052684005722 Walker A/P-loop; other site 1052684005723 ATP binding site [chemical binding]; other site 1052684005724 Q-loop/lid; other site 1052684005725 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1052684005726 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1052684005727 ABC transporter signature motif; other site 1052684005728 Walker B; other site 1052684005729 D-loop; other site 1052684005730 H-loop/switch region; other site 1052684005731 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1052684005732 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1052684005733 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1052684005734 P loop; other site 1052684005735 GTP binding site [chemical binding]; other site 1052684005736 Haemolysin-III related; Region: HlyIII; cl03831 1052684005737 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1052684005738 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1052684005739 putative DNA-binding protein; Validated; Region: PRK00118 1052684005740 signal recognition particle protein; Provisional; Region: PRK10867 1052684005741 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1052684005742 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1052684005743 P loop; other site 1052684005744 GTP binding site [chemical binding]; other site 1052684005745 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1052684005746 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1052684005747 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1052684005748 hypothetical protein; Provisional; Region: PRK00468 1052684005749 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1052684005750 RimM N-terminal domain; Region: RimM; pfam01782 1052684005751 PRC-barrel domain; Region: PRC; pfam05239 1052684005752 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1052684005753 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1052684005754 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052684005755 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052684005756 Catalytic site [active] 1052684005757 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 1052684005758 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052684005759 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 1052684005760 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1052684005761 GTP/Mg2+ binding site [chemical binding]; other site 1052684005762 G4 box; other site 1052684005763 G5 box; other site 1052684005764 G1 box; other site 1052684005765 Switch I region; other site 1052684005766 G2 box; other site 1052684005767 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 1052684005768 G3 box; other site 1052684005769 Switch II region; other site 1052684005770 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1052684005771 RNA/DNA hybrid binding site [nucleotide binding]; other site 1052684005772 active site 1052684005773 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1052684005774 hypothetical protein; Reviewed; Region: PRK12497 1052684005775 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1052684005776 putative FMN binding site [chemical binding]; other site 1052684005777 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1052684005778 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1052684005779 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1052684005780 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1052684005781 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1052684005782 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1052684005783 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1052684005784 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684005785 MarR family; Region: MarR; pfam01047 1052684005786 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1052684005787 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1052684005788 CoA-ligase; Region: Ligase_CoA; pfam00549 1052684005789 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1052684005790 CoA binding domain; Region: CoA_binding; smart00881 1052684005791 CoA-ligase; Region: Ligase_CoA; pfam00549 1052684005792 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1052684005793 DNA protecting protein DprA; Region: dprA; TIGR00732 1052684005794 DNA topoisomerase I; Validated; Region: PRK05582 1052684005795 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1052684005796 active site 1052684005797 interdomain interaction site; other site 1052684005798 putative metal-binding site [ion binding]; other site 1052684005799 nucleotide binding site [chemical binding]; other site 1052684005800 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1052684005801 domain I; other site 1052684005802 DNA binding groove [nucleotide binding] 1052684005803 phosphate binding site [ion binding]; other site 1052684005804 domain II; other site 1052684005805 domain III; other site 1052684005806 nucleotide binding site [chemical binding]; other site 1052684005807 catalytic site [active] 1052684005808 domain IV; other site 1052684005809 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1052684005810 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1052684005811 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1052684005812 Glucose inhibited division protein A; Region: GIDA; pfam01134 1052684005813 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1052684005814 active site 1052684005815 HslU subunit interaction site [polypeptide binding]; other site 1052684005816 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1052684005817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684005818 Walker A motif; other site 1052684005819 ATP binding site [chemical binding]; other site 1052684005820 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1052684005821 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1052684005822 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 1052684005823 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1052684005824 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1052684005825 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1052684005826 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 1052684005827 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 1052684005828 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1052684005829 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1052684005830 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1052684005831 FliG C-terminal domain; Region: FliG_C; pfam01706 1052684005832 Flagellar assembly protein FliH; Region: FliH; pfam02108 1052684005833 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 1052684005834 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1052684005835 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1052684005836 Walker A motif/ATP binding site; other site 1052684005837 Walker B motif; other site 1052684005838 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1052684005839 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 1052684005840 Uncharacterized conserved protein [Function unknown]; Region: COG3334 1052684005841 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1052684005842 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 1052684005843 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1052684005844 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 1052684005845 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 1052684005846 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1052684005847 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1052684005848 Flagellar protein (FlbD); Region: FlbD; pfam06289 1052684005849 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 1052684005850 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1052684005851 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1052684005852 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1052684005853 CheC-like family; Region: CheC; pfam04509 1052684005854 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1052684005855 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684005856 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684005857 active site 1052684005858 phosphorylation site [posttranslational modification] 1052684005859 intermolecular recognition site; other site 1052684005860 dimerization interface [polypeptide binding]; other site 1052684005861 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 1052684005862 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1052684005863 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1052684005864 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1052684005865 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1052684005866 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1052684005867 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1052684005868 FHIPEP family; Region: FHIPEP; pfam00771 1052684005869 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 1052684005870 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1052684005871 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 1052684005872 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 1052684005873 P-loop; other site 1052684005874 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684005875 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684005876 active site 1052684005877 phosphorylation site [posttranslational modification] 1052684005878 intermolecular recognition site; other site 1052684005879 dimerization interface [polypeptide binding]; other site 1052684005880 CheB methylesterase; Region: CheB_methylest; pfam01339 1052684005881 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 1052684005882 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1052684005883 putative binding surface; other site 1052684005884 active site 1052684005885 P2 response regulator binding domain; Region: P2; pfam07194 1052684005886 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1052684005887 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684005888 ATP binding site [chemical binding]; other site 1052684005889 Mg2+ binding site [ion binding]; other site 1052684005890 G-X-G motif; other site 1052684005891 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1052684005892 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1052684005893 putative CheA interaction surface; other site 1052684005894 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 1052684005895 CheC-like family; Region: CheC; pfam04509 1052684005896 CheC-like family; Region: CheC; pfam04509 1052684005897 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 1052684005898 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 1052684005899 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684005900 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052684005901 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684005902 DNA binding residues [nucleotide binding] 1052684005903 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1052684005904 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1052684005905 YceG-like family; Region: YceG; pfam02618 1052684005906 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684005907 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1052684005908 rRNA interaction site [nucleotide binding]; other site 1052684005909 S8 interaction site; other site 1052684005910 putative laminin-1 binding site; other site 1052684005911 elongation factor Ts; Reviewed; Region: tsf; PRK12332 1052684005912 UBA/TS-N domain; Region: UBA; pfam00627 1052684005913 Elongation factor TS; Region: EF_TS; pfam00889 1052684005914 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1052684005915 putative nucleotide binding site [chemical binding]; other site 1052684005916 uridine monophosphate binding site [chemical binding]; other site 1052684005917 homohexameric interface [polypeptide binding]; other site 1052684005918 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1052684005919 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1052684005920 hinge region; other site 1052684005921 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1052684005922 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1052684005923 catalytic residue [active] 1052684005924 putative FPP diphosphate binding site; other site 1052684005925 putative FPP binding hydrophobic cleft; other site 1052684005926 dimer interface [polypeptide binding]; other site 1052684005927 putative IPP diphosphate binding site; other site 1052684005928 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1052684005929 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1052684005930 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1052684005931 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1052684005932 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1052684005933 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1052684005934 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1052684005935 RIP metalloprotease RseP; Region: TIGR00054 1052684005936 active site 1052684005937 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1052684005938 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1052684005939 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1052684005940 putative substrate binding region [chemical binding]; other site 1052684005941 prolyl-tRNA synthetase; Provisional; Region: PRK08661 1052684005942 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 1052684005943 dimer interface [polypeptide binding]; other site 1052684005944 motif 1; other site 1052684005945 active site 1052684005946 motif 2; other site 1052684005947 motif 3; other site 1052684005948 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 1052684005949 anticodon binding site; other site 1052684005950 zinc-binding site [ion binding]; other site 1052684005951 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1052684005952 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1052684005953 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1052684005954 generic binding surface II; other site 1052684005955 generic binding surface I; other site 1052684005956 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1052684005957 active site 1052684005958 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1052684005959 active site 1052684005960 catalytic site [active] 1052684005961 substrate binding site [chemical binding]; other site 1052684005962 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1052684005963 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1052684005964 Sm and related proteins; Region: Sm_like; cl00259 1052684005965 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1052684005966 putative oligomer interface [polypeptide binding]; other site 1052684005967 putative RNA binding site [nucleotide binding]; other site 1052684005968 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1052684005969 NusA N-terminal domain; Region: NusA_N; pfam08529 1052684005970 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1052684005971 RNA binding site [nucleotide binding]; other site 1052684005972 homodimer interface [polypeptide binding]; other site 1052684005973 NusA-like KH domain; Region: KH_5; pfam13184 1052684005974 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1052684005975 G-X-X-G motif; other site 1052684005976 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1052684005977 putative RNA binding cleft [nucleotide binding]; other site 1052684005978 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 1052684005979 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1052684005980 translation initiation factor IF-2; Region: IF-2; TIGR00487 1052684005981 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1052684005982 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1052684005983 G1 box; other site 1052684005984 putative GEF interaction site [polypeptide binding]; other site 1052684005985 GTP/Mg2+ binding site [chemical binding]; other site 1052684005986 Switch I region; other site 1052684005987 G2 box; other site 1052684005988 G3 box; other site 1052684005989 Switch II region; other site 1052684005990 G4 box; other site 1052684005991 G5 box; other site 1052684005992 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1052684005993 Translation-initiation factor 2; Region: IF-2; pfam11987 1052684005994 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1052684005995 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1052684005996 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1052684005997 DHH family; Region: DHH; pfam01368 1052684005998 DHHA1 domain; Region: DHHA1; pfam02272 1052684005999 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 1052684006000 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1052684006001 RNA binding site [nucleotide binding]; other site 1052684006002 active site 1052684006003 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1052684006004 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1052684006005 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1052684006006 active site 1052684006007 Riboflavin kinase; Region: Flavokinase; smart00904 1052684006008 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1052684006009 16S/18S rRNA binding site [nucleotide binding]; other site 1052684006010 S13e-L30e interaction site [polypeptide binding]; other site 1052684006011 25S rRNA binding site [nucleotide binding]; other site 1052684006012 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1052684006013 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1052684006014 RNase E interface [polypeptide binding]; other site 1052684006015 trimer interface [polypeptide binding]; other site 1052684006016 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1052684006017 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1052684006018 RNase E interface [polypeptide binding]; other site 1052684006019 trimer interface [polypeptide binding]; other site 1052684006020 active site 1052684006021 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1052684006022 putative nucleic acid binding region [nucleotide binding]; other site 1052684006023 G-X-X-G motif; other site 1052684006024 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1052684006025 RNA binding site [nucleotide binding]; other site 1052684006026 domain interface; other site 1052684006027 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 1052684006028 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 1052684006029 NodB motif; other site 1052684006030 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052684006031 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1052684006032 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052684006033 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1052684006034 trimer interface [polypeptide binding]; other site 1052684006035 active site 1052684006036 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 1052684006037 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1052684006038 NAD binding site [chemical binding]; other site 1052684006039 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 1052684006040 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1052684006041 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1052684006042 aspartate kinase I; Reviewed; Region: PRK08210 1052684006043 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1052684006044 nucleotide binding site [chemical binding]; other site 1052684006045 substrate binding site [chemical binding]; other site 1052684006046 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 1052684006047 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1052684006048 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1052684006049 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1052684006050 dimer interface [polypeptide binding]; other site 1052684006051 active site 1052684006052 catalytic residue [active] 1052684006053 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1052684006054 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052684006055 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1052684006056 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1052684006057 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1052684006058 active site 1052684006059 YlzJ-like protein; Region: YlzJ; pfam14035 1052684006060 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1052684006061 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1052684006062 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1052684006063 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1052684006064 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1052684006065 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052684006066 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052684006067 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052684006068 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052684006069 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1052684006070 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1052684006071 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1052684006072 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1052684006073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684006074 NAD(P) binding site [chemical binding]; other site 1052684006075 active site 1052684006076 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1052684006077 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1052684006078 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 1052684006079 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1052684006080 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684006081 non-specific DNA binding site [nucleotide binding]; other site 1052684006082 salt bridge; other site 1052684006083 sequence-specific DNA binding site [nucleotide binding]; other site 1052684006084 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1052684006085 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1052684006086 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1052684006087 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1052684006088 competence damage-inducible protein A; Provisional; Region: PRK00549 1052684006089 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1052684006090 putative MPT binding site; other site 1052684006091 Competence-damaged protein; Region: CinA; pfam02464 1052684006092 recombinase A; Provisional; Region: recA; PRK09354 1052684006093 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1052684006094 hexamer interface [polypeptide binding]; other site 1052684006095 Walker A motif; other site 1052684006096 ATP binding site [chemical binding]; other site 1052684006097 Walker B motif; other site 1052684006098 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1052684006099 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 1052684006100 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1052684006101 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052684006102 Zn2+ binding site [ion binding]; other site 1052684006103 Mg2+ binding site [ion binding]; other site 1052684006104 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052684006105 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 1052684006106 putative active site [active] 1052684006107 metal binding site [ion binding]; metal-binding site 1052684006108 homodimer binding site [polypeptide binding]; other site 1052684006109 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 1052684006110 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 1052684006111 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 1052684006112 active site 1052684006113 dimer interface [polypeptide binding]; other site 1052684006114 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1052684006115 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 1052684006116 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1052684006117 Propanediol utilisation protein PduL; Region: PduL; pfam06130 1052684006118 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 1052684006119 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1052684006120 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684006121 FeS/SAM binding site; other site 1052684006122 Protein of unknown function (DUF964); Region: DUF964; cl01483 1052684006123 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1052684006124 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 1052684006125 CoenzymeA binding site [chemical binding]; other site 1052684006126 subunit interaction site [polypeptide binding]; other site 1052684006127 PHB binding site; other site 1052684006128 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1052684006129 nudix motif; other site 1052684006130 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1052684006131 Isochorismatase family; Region: Isochorismatase; pfam00857 1052684006132 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1052684006133 catalytic triad [active] 1052684006134 conserved cis-peptide bond; other site 1052684006135 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1052684006136 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1052684006137 active site 1052684006138 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1052684006139 MPT binding site; other site 1052684006140 trimer interface [polypeptide binding]; other site 1052684006141 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 1052684006142 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1052684006143 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1052684006144 active site 1052684006145 HIGH motif; other site 1052684006146 KMSK motif region; other site 1052684006147 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1052684006148 tRNA binding surface [nucleotide binding]; other site 1052684006149 anticodon binding site; other site 1052684006150 S-layer homology domain; Region: SLH; pfam00395 1052684006151 PrcB C-terminal; Region: PrcB_C; pfam14343 1052684006152 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684006153 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684006154 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1052684006155 Walker A/P-loop; other site 1052684006156 ATP binding site [chemical binding]; other site 1052684006157 Q-loop/lid; other site 1052684006158 ABC transporter signature motif; other site 1052684006159 Walker B; other site 1052684006160 D-loop; other site 1052684006161 H-loop/switch region; other site 1052684006162 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684006163 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1052684006164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684006165 Walker A/P-loop; other site 1052684006166 ATP binding site [chemical binding]; other site 1052684006167 Q-loop/lid; other site 1052684006168 ABC transporter signature motif; other site 1052684006169 Walker B; other site 1052684006170 D-loop; other site 1052684006171 H-loop/switch region; other site 1052684006172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 1052684006173 Predicted membrane protein [Function unknown]; Region: COG2707 1052684006174 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1052684006175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1052684006176 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684006177 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684006178 putative DNA binding site [nucleotide binding]; other site 1052684006179 dimerization interface [polypeptide binding]; other site 1052684006180 putative Zn2+ binding site [ion binding]; other site 1052684006181 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 1052684006182 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052684006183 ribosome small subunit-dependent GTPase A; Region: TIGR00157 1052684006184 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1052684006185 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1052684006186 GTP/Mg2+ binding site [chemical binding]; other site 1052684006187 G4 box; other site 1052684006188 G5 box; other site 1052684006189 G1 box; other site 1052684006190 Switch I region; other site 1052684006191 G2 box; other site 1052684006192 G3 box; other site 1052684006193 Switch II region; other site 1052684006194 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1052684006195 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1052684006196 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1052684006197 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1052684006198 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1052684006199 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1052684006200 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1052684006201 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1052684006202 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1052684006203 metal ion-dependent adhesion site (MIDAS); other site 1052684006204 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1052684006205 active site 1052684006206 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052684006207 classical (c) SDRs; Region: SDR_c; cd05233 1052684006208 NAD(P) binding site [chemical binding]; other site 1052684006209 active site 1052684006210 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684006211 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 1052684006212 ATP binding site [chemical binding]; other site 1052684006213 Chloramphenicol (Cm) binding site [chemical binding]; other site 1052684006214 hypothetical protein; Provisional; Region: PRK06761 1052684006215 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684006216 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684006217 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684006218 translocation protein TolB; Provisional; Region: tolB; PRK04922 1052684006219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684006220 salt bridge; other site 1052684006221 non-specific DNA binding site [nucleotide binding]; other site 1052684006222 sequence-specific DNA binding site [nucleotide binding]; other site 1052684006223 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 1052684006224 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1052684006225 active site 1052684006226 HIGH motif; other site 1052684006227 nucleotide binding site [chemical binding]; other site 1052684006228 active site 1052684006229 KMSKS motif; other site 1052684006230 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 1052684006231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052684006232 ATP binding site [chemical binding]; other site 1052684006233 putative Mg++ binding site [ion binding]; other site 1052684006234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684006235 nucleotide binding region [chemical binding]; other site 1052684006236 ATP-binding site [chemical binding]; other site 1052684006237 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1052684006238 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1052684006239 Heat induced stress protein YflT; Region: YflT; pfam11181 1052684006240 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1052684006241 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1052684006242 Replication terminator protein; Region: RTP; pfam02334 1052684006243 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052684006244 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684006245 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052684006246 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1052684006247 DivIVA protein; Region: DivIVA; pfam05103 1052684006248 DivIVA domain; Region: DivI1A_domain; TIGR03544 1052684006249 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1052684006250 Rrf2 family protein; Region: rrf2_super; TIGR00738 1052684006251 Transcriptional regulator; Region: Rrf2; pfam02082 1052684006252 Transcriptional regulator; Region: Rrf2; cl17282 1052684006253 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1052684006254 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052684006255 active site 1052684006256 metal binding site [ion binding]; metal-binding site 1052684006257 homotetramer interface [polypeptide binding]; other site 1052684006258 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 1052684006259 dimer interface [polypeptide binding]; other site 1052684006260 [2Fe-2S] cluster binding site [ion binding]; other site 1052684006261 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 1052684006262 dimer interface [polypeptide binding]; other site 1052684006263 FMN binding site [chemical binding]; other site 1052684006264 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1052684006265 cobyric acid synthase; Provisional; Region: PRK00784 1052684006266 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684006267 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052684006268 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1052684006269 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1052684006270 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1052684006271 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 1052684006272 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1052684006273 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1052684006274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684006275 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684006276 putative substrate translocation pore; other site 1052684006277 OsmC-like protein; Region: OsmC; cl00767 1052684006278 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1052684006279 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1052684006280 azoreductase; Provisional; Region: PRK13556 1052684006281 glutamate racemase; Provisional; Region: PRK00865 1052684006282 Phosphotransferase enzyme family; Region: APH; pfam01636 1052684006283 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 1052684006284 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 1052684006285 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1052684006286 active site 1052684006287 metal binding site [ion binding]; metal-binding site 1052684006288 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1052684006289 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1052684006290 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 1052684006291 active site 1052684006292 catalytic residues [active] 1052684006293 Tetratrico peptide repeat; Region: TPR_5; pfam12688 1052684006294 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 1052684006295 acetolactate synthase; Reviewed; Region: PRK08617 1052684006296 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1052684006297 PYR/PP interface [polypeptide binding]; other site 1052684006298 dimer interface [polypeptide binding]; other site 1052684006299 TPP binding site [chemical binding]; other site 1052684006300 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1052684006301 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 1052684006302 TPP-binding site [chemical binding]; other site 1052684006303 dimer interface [polypeptide binding]; other site 1052684006304 Glucuronate isomerase; Region: UxaC; pfam02614 1052684006305 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1052684006306 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1052684006307 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684006308 putative substrate translocation pore; other site 1052684006309 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684006310 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684006311 DNA binding site [nucleotide binding] 1052684006312 domain linker motif; other site 1052684006313 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052684006314 dimerization interface [polypeptide binding]; other site 1052684006315 ligand binding site [chemical binding]; other site 1052684006316 pyruvate dehydrogenase; Provisional; Region: PRK09124 1052684006317 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1052684006318 PYR/PP interface [polypeptide binding]; other site 1052684006319 dimer interface [polypeptide binding]; other site 1052684006320 tetramer interface [polypeptide binding]; other site 1052684006321 TPP binding site [chemical binding]; other site 1052684006322 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1052684006323 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1052684006324 TPP-binding site [chemical binding]; other site 1052684006325 altronate oxidoreductase; Provisional; Region: PRK03643 1052684006326 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1052684006327 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1052684006328 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1052684006329 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1052684006330 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1052684006331 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052684006332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684006333 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052684006334 Coenzyme A binding pocket [chemical binding]; other site 1052684006335 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 1052684006336 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684006337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684006338 dimer interface [polypeptide binding]; other site 1052684006339 conserved gate region; other site 1052684006340 ABC-ATPase subunit interface; other site 1052684006341 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684006342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684006343 dimer interface [polypeptide binding]; other site 1052684006344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1052684006345 ABC-ATPase subunit interface; other site 1052684006346 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684006347 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052684006348 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684006349 dimerization interface [polypeptide binding]; other site 1052684006350 Histidine kinase; Region: His_kinase; pfam06580 1052684006351 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684006352 ATP binding site [chemical binding]; other site 1052684006353 Mg2+ binding site [ion binding]; other site 1052684006354 G-X-G motif; other site 1052684006355 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684006356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684006357 active site 1052684006358 phosphorylation site [posttranslational modification] 1052684006359 intermolecular recognition site; other site 1052684006360 dimerization interface [polypeptide binding]; other site 1052684006361 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684006362 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684006363 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684006364 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 1052684006365 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1052684006366 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1052684006367 ligand binding site; other site 1052684006368 oligomer interface; other site 1052684006369 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1052684006370 dimer interface [polypeptide binding]; other site 1052684006371 N-terminal domain interface [polypeptide binding]; other site 1052684006372 sulfate 1 binding site; other site 1052684006373 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1052684006374 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1052684006375 ligand binding site; other site 1052684006376 oligomer interface; other site 1052684006377 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1052684006378 dimer interface [polypeptide binding]; other site 1052684006379 N-terminal domain interface [polypeptide binding]; other site 1052684006380 sulfate 1 binding site; other site 1052684006381 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1052684006382 homodimer interface [polypeptide binding]; other site 1052684006383 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1052684006384 active site pocket [active] 1052684006385 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 1052684006386 Predicted membrane protein [Function unknown]; Region: COG1511 1052684006387 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1052684006388 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1052684006389 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052684006390 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052684006391 active site 1052684006392 catalytic tetrad [active] 1052684006393 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 1052684006394 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1052684006395 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1052684006396 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1052684006397 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684006398 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684006399 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684006400 dimerization interface [polypeptide binding]; other site 1052684006401 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 1052684006402 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684006403 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 1052684006404 Walker A/P-loop; other site 1052684006405 ATP binding site [chemical binding]; other site 1052684006406 Q-loop/lid; other site 1052684006407 ABC transporter signature motif; other site 1052684006408 Walker B; other site 1052684006409 D-loop; other site 1052684006410 H-loop/switch region; other site 1052684006411 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1052684006412 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1052684006413 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684006414 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684006415 active site 1052684006416 phosphorylation site [posttranslational modification] 1052684006417 intermolecular recognition site; other site 1052684006418 dimerization interface [polypeptide binding]; other site 1052684006419 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684006420 DNA binding site [nucleotide binding] 1052684006421 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684006422 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684006423 dimer interface [polypeptide binding]; other site 1052684006424 phosphorylation site [posttranslational modification] 1052684006425 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684006426 ATP binding site [chemical binding]; other site 1052684006427 Mg2+ binding site [ion binding]; other site 1052684006428 G-X-G motif; other site 1052684006429 DinB superfamily; Region: DinB_2; pfam12867 1052684006430 Predicted membrane protein [Function unknown]; Region: COG2323 1052684006431 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1052684006432 catalytic residues [active] 1052684006433 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 1052684006434 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 1052684006435 active site 1052684006436 non-prolyl cis peptide bond; other site 1052684006437 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 1052684006438 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052684006439 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684006440 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684006441 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684006442 dimerization interface [polypeptide binding]; other site 1052684006443 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052684006444 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052684006445 substrate binding pocket [chemical binding]; other site 1052684006446 membrane-bound complex binding site; other site 1052684006447 hinge residues; other site 1052684006448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684006449 dimer interface [polypeptide binding]; other site 1052684006450 conserved gate region; other site 1052684006451 putative PBP binding loops; other site 1052684006452 ABC-ATPase subunit interface; other site 1052684006453 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052684006454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684006455 dimer interface [polypeptide binding]; other site 1052684006456 conserved gate region; other site 1052684006457 putative PBP binding loops; other site 1052684006458 ABC-ATPase subunit interface; other site 1052684006459 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052684006460 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052684006461 Walker A/P-loop; other site 1052684006462 ATP binding site [chemical binding]; other site 1052684006463 Q-loop/lid; other site 1052684006464 ABC transporter signature motif; other site 1052684006465 Walker B; other site 1052684006466 D-loop; other site 1052684006467 H-loop/switch region; other site 1052684006468 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052684006469 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1052684006470 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052684006471 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1052684006472 metal binding site [ion binding]; metal-binding site 1052684006473 dimer interface [polypeptide binding]; other site 1052684006474 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1052684006475 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1052684006476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684006477 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052684006478 putative substrate translocation pore; other site 1052684006479 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684006480 dimerization interface [polypeptide binding]; other site 1052684006481 putative DNA binding site [nucleotide binding]; other site 1052684006482 putative Zn2+ binding site [ion binding]; other site 1052684006483 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684006484 dimerization interface [polypeptide binding]; other site 1052684006485 putative DNA binding site [nucleotide binding]; other site 1052684006486 putative Zn2+ binding site [ion binding]; other site 1052684006487 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1052684006488 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1052684006489 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052684006490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684006491 dimer interface [polypeptide binding]; other site 1052684006492 conserved gate region; other site 1052684006493 putative PBP binding loops; other site 1052684006494 ABC-ATPase subunit interface; other site 1052684006495 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052684006496 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052684006497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684006498 dimer interface [polypeptide binding]; other site 1052684006499 conserved gate region; other site 1052684006500 putative PBP binding loops; other site 1052684006501 ABC-ATPase subunit interface; other site 1052684006502 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052684006503 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052684006504 Walker A/P-loop; other site 1052684006505 ATP binding site [chemical binding]; other site 1052684006506 Q-loop/lid; other site 1052684006507 ABC transporter signature motif; other site 1052684006508 Walker B; other site 1052684006509 D-loop; other site 1052684006510 H-loop/switch region; other site 1052684006511 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1052684006512 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 1052684006513 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052684006514 Walker A/P-loop; other site 1052684006515 ATP binding site [chemical binding]; other site 1052684006516 Q-loop/lid; other site 1052684006517 ABC transporter signature motif; other site 1052684006518 Walker B; other site 1052684006519 D-loop; other site 1052684006520 H-loop/switch region; other site 1052684006521 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1052684006522 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1052684006523 Cation efflux family; Region: Cation_efflux; pfam01545 1052684006524 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1052684006525 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1052684006526 Predicted membrane protein/domain [Function unknown]; Region: COG1714 1052684006527 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684006528 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1052684006529 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1052684006530 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052684006531 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052684006532 dimer interface [polypeptide binding]; other site 1052684006533 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684006534 catalytic residue [active] 1052684006535 cystathionine beta-lyase; Provisional; Region: PRK07671 1052684006536 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052684006537 homodimer interface [polypeptide binding]; other site 1052684006538 substrate-cofactor binding pocket; other site 1052684006539 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684006540 catalytic residue [active] 1052684006541 Predicted esterase [General function prediction only]; Region: COG0400 1052684006542 Nucleolar RNA-binding protein, Nop10p family; Region: Nop10p; cl00977 1052684006543 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1052684006544 metal ion-dependent adhesion site (MIDAS); other site 1052684006545 Tubulin like; Region: Tubulin_2; pfam13809 1052684006546 Tubulin like; Region: Tubulin_2; pfam13809 1052684006547 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1052684006548 metal ion-dependent adhesion site (MIDAS); other site 1052684006549 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1052684006550 MarR family; Region: MarR_2; pfam12802 1052684006551 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684006552 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684006553 putative substrate translocation pore; other site 1052684006554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684006555 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1052684006556 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1052684006557 S-layer homology domain; Region: SLH; pfam00395 1052684006558 S-layer homology domain; Region: SLH; pfam00395 1052684006559 flagellin; Validated; Region: PRK08026 1052684006560 S-layer homology domain; Region: SLH; pfam00395 1052684006561 S-layer homology domain; Region: SLH; pfam00395 1052684006562 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1052684006563 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1052684006564 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1052684006565 TIGR03943 family protein; Region: TIGR03943 1052684006566 Predicted permeases [General function prediction only]; Region: COG0701 1052684006567 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1052684006568 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1052684006569 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1052684006570 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052684006571 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684006572 ABC-ATPase subunit interface; other site 1052684006573 dimer interface [polypeptide binding]; other site 1052684006574 putative PBP binding regions; other site 1052684006575 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052684006576 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052684006577 Walker A/P-loop; other site 1052684006578 ATP binding site [chemical binding]; other site 1052684006579 Q-loop/lid; other site 1052684006580 ABC transporter signature motif; other site 1052684006581 Walker B; other site 1052684006582 D-loop; other site 1052684006583 H-loop/switch region; other site 1052684006584 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 1052684006585 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 1052684006586 putative ligand binding residues [chemical binding]; other site 1052684006587 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1052684006588 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052684006589 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1052684006590 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684006591 ABC-ATPase subunit interface; other site 1052684006592 dimer interface [polypeptide binding]; other site 1052684006593 putative PBP binding regions; other site 1052684006594 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1052684006595 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1052684006596 metal binding site [ion binding]; metal-binding site 1052684006597 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1052684006598 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1052684006599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684006600 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1052684006601 Walker A/P-loop; other site 1052684006602 ATP binding site [chemical binding]; other site 1052684006603 Q-loop/lid; other site 1052684006604 ABC transporter signature motif; other site 1052684006605 Walker B; other site 1052684006606 D-loop; other site 1052684006607 H-loop/switch region; other site 1052684006608 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684006609 MarR family; Region: MarR_2; pfam12802 1052684006610 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684006611 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684006612 active site 1052684006613 phosphorylation site [posttranslational modification] 1052684006614 intermolecular recognition site; other site 1052684006615 dimerization interface [polypeptide binding]; other site 1052684006616 Ycf1; Region: Ycf1; pfam05758 1052684006617 WYL domain; Region: WYL; cl14852 1052684006618 YolD-like protein; Region: YolD; pfam08863 1052684006619 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1052684006620 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1052684006621 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 1052684006622 S-layer homology domain; Region: SLH; pfam00395 1052684006623 S-layer homology domain; Region: SLH; pfam00395 1052684006624 S-layer homology domain; Region: SLH; pfam00395 1052684006625 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052684006626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684006627 S-adenosylmethionine binding site [chemical binding]; other site 1052684006628 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1052684006629 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052684006630 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052684006631 active site 1052684006632 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052684006633 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052684006634 active site 1052684006635 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1052684006636 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052684006637 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052684006638 catalytic residue [active] 1052684006639 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1052684006640 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1052684006641 putative trimer interface [polypeptide binding]; other site 1052684006642 putative CoA binding site [chemical binding]; other site 1052684006643 short chain dehydrogenase; Validated; Region: PRK08324 1052684006644 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1052684006645 active site 1052684006646 intersubunit interface [polypeptide binding]; other site 1052684006647 Zn2+ binding site [ion binding]; other site 1052684006648 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 1052684006649 putative NAD(P) binding site [chemical binding]; other site 1052684006650 active site 1052684006651 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 1052684006652 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1052684006653 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1052684006654 N- and C-terminal domain interface [polypeptide binding]; other site 1052684006655 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1052684006656 active site 1052684006657 putative catalytic site [active] 1052684006658 metal binding site [ion binding]; metal-binding site 1052684006659 ATP binding site [chemical binding]; other site 1052684006660 carbohydrate binding site [chemical binding]; other site 1052684006661 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052684006662 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1052684006663 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1052684006664 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1052684006665 Cysteine-rich domain; Region: CCG; pfam02754 1052684006666 Cysteine-rich domain; Region: CCG; pfam02754 1052684006667 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1052684006668 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1052684006669 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1052684006670 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1052684006671 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1052684006672 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 1052684006673 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684006674 dimerization interface [polypeptide binding]; other site 1052684006675 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684006676 dimer interface [polypeptide binding]; other site 1052684006677 phosphorylation site [posttranslational modification] 1052684006678 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684006679 ATP binding site [chemical binding]; other site 1052684006680 Mg2+ binding site [ion binding]; other site 1052684006681 G-X-G motif; other site 1052684006682 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684006683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684006684 active site 1052684006685 phosphorylation site [posttranslational modification] 1052684006686 intermolecular recognition site; other site 1052684006687 dimerization interface [polypeptide binding]; other site 1052684006688 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684006689 DNA binding site [nucleotide binding] 1052684006690 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1052684006691 CHRD domain; Region: CHRD; pfam07452 1052684006692 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052684006693 active site 1052684006694 catalytic triad [active] 1052684006695 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1052684006696 DNA binding site [nucleotide binding] 1052684006697 active site 1052684006698 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1052684006699 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1052684006700 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1052684006701 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052684006702 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052684006703 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052684006704 Walker A/P-loop; other site 1052684006705 ATP binding site [chemical binding]; other site 1052684006706 Q-loop/lid; other site 1052684006707 ABC transporter signature motif; other site 1052684006708 Walker B; other site 1052684006709 D-loop; other site 1052684006710 H-loop/switch region; other site 1052684006711 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052684006712 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052684006713 FtsX-like permease family; Region: FtsX; pfam02687 1052684006714 HTH domain; Region: HTH_11; pfam08279 1052684006715 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1052684006716 FOG: CBS domain [General function prediction only]; Region: COG0517 1052684006717 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 1052684006718 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1052684006719 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1052684006720 putative active site [active] 1052684006721 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1052684006722 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684006723 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052684006724 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1052684006725 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052684006726 acyl-activating enzyme (AAE) consensus motif; other site 1052684006727 AMP binding site [chemical binding]; other site 1052684006728 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684006729 Condensation domain; Region: Condensation; pfam00668 1052684006730 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684006731 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684006732 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052684006733 acyl-activating enzyme (AAE) consensus motif; other site 1052684006734 AMP binding site [chemical binding]; other site 1052684006735 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684006736 Condensation domain; Region: Condensation; pfam00668 1052684006737 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684006738 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684006739 Condensation domain; Region: Condensation; pfam00668 1052684006740 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684006741 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684006742 acyl-activating enzyme (AAE) consensus motif; other site 1052684006743 AMP binding site [chemical binding]; other site 1052684006744 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684006745 Thioesterase domain; Region: Thioesterase; pfam00975 1052684006746 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052684006747 Beta-lactamase; Region: Beta-lactamase; pfam00144 1052684006748 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 1052684006749 generic binding surface II; other site 1052684006750 generic binding surface I; other site 1052684006751 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 1052684006752 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1052684006753 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1052684006754 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1052684006755 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1052684006756 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1052684006757 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1052684006758 HTH domain; Region: HTH_11; pfam08279 1052684006759 3H domain; Region: 3H; pfam02829 1052684006760 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052684006761 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1052684006762 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052684006763 catalytic residue [active] 1052684006764 quinolinate synthetase; Provisional; Region: PRK09375 1052684006765 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1052684006766 PQQ-like domain; Region: PQQ_2; pfam13360 1052684006767 active site 1052684006768 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1052684006769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684006770 Coenzyme A binding pocket [chemical binding]; other site 1052684006771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052684006772 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1052684006773 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1052684006774 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1052684006775 active site 1052684006776 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1052684006777 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1052684006778 active site 1052684006779 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684006780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684006781 active site 1052684006782 phosphorylation site [posttranslational modification] 1052684006783 intermolecular recognition site; other site 1052684006784 dimerization interface [polypeptide binding]; other site 1052684006785 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684006786 DNA binding site [nucleotide binding] 1052684006787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684006788 HAMP domain; Region: HAMP; pfam00672 1052684006789 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684006790 dimer interface [polypeptide binding]; other site 1052684006791 phosphorylation site [posttranslational modification] 1052684006792 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684006793 ATP binding site [chemical binding]; other site 1052684006794 Mg2+ binding site [ion binding]; other site 1052684006795 G-X-G motif; other site 1052684006796 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052684006797 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 1052684006798 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684006799 putative ADP-binding pocket [chemical binding]; other site 1052684006800 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1052684006801 active site 1052684006802 Zn binding site [ion binding]; other site 1052684006803 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052684006804 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1052684006805 active site 1052684006806 Cupin domain; Region: Cupin_2; cl17218 1052684006807 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1052684006808 Cupin; Region: Cupin_1; smart00835 1052684006809 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052684006810 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052684006811 Walker A/P-loop; other site 1052684006812 ATP binding site [chemical binding]; other site 1052684006813 Q-loop/lid; other site 1052684006814 ABC transporter signature motif; other site 1052684006815 Walker B; other site 1052684006816 D-loop; other site 1052684006817 H-loop/switch region; other site 1052684006818 Predicted permeases [General function prediction only]; Region: COG0679 1052684006819 hypothetical protein; Validated; Region: PRK01415 1052684006820 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1052684006821 active site residue [active] 1052684006822 alpha-galactosidase; Region: PLN02808; cl17638 1052684006823 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1052684006824 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052684006825 substrate binding site [chemical binding]; other site 1052684006826 ATP binding site [chemical binding]; other site 1052684006827 topology modulation protein; Reviewed; Region: PRK08118 1052684006828 AAA domain; Region: AAA_17; pfam13207 1052684006829 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1052684006830 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1052684006831 dimer interface [polypeptide binding]; other site 1052684006832 motif 1; other site 1052684006833 active site 1052684006834 motif 2; other site 1052684006835 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1052684006836 putative deacylase active site [active] 1052684006837 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1052684006838 active site 1052684006839 motif 3; other site 1052684006840 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1052684006841 anticodon binding site; other site 1052684006842 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1052684006843 hypothetical protein; Provisional; Region: PRK12378 1052684006844 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684006845 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684006846 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 1052684006847 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684006848 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1052684006849 NAD(P) binding site [chemical binding]; other site 1052684006850 active site 1052684006851 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 1052684006852 Cupin; Region: Cupin_1; smart00835 1052684006853 Cupin; Region: Cupin_1; smart00835 1052684006854 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1052684006855 putative deacylase active site [active] 1052684006856 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 1052684006857 L11 interface [polypeptide binding]; other site 1052684006858 putative EF-Tu interaction site [polypeptide binding]; other site 1052684006859 putative EF-G interaction site [polypeptide binding]; other site 1052684006860 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1052684006861 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052684006862 nucleotide binding site [chemical binding]; other site 1052684006863 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1052684006864 beta-galactosidase; Region: BGL; TIGR03356 1052684006865 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1052684006866 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052684006867 active site 1052684006868 metal binding site [ion binding]; metal-binding site 1052684006869 homotetramer interface [polypeptide binding]; other site 1052684006870 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1052684006871 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1052684006872 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1052684006873 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1052684006874 putative active site; other site 1052684006875 catalytic triad [active] 1052684006876 putative dimer interface [polypeptide binding]; other site 1052684006877 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1052684006878 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 1052684006879 active site 1052684006880 FMN binding site [chemical binding]; other site 1052684006881 substrate binding site [chemical binding]; other site 1052684006882 putative catalytic residue [active] 1052684006883 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1052684006884 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684006885 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684006886 Phosphotransferase enzyme family; Region: APH; pfam01636 1052684006887 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1052684006888 active site 1052684006889 substrate binding site [chemical binding]; other site 1052684006890 ATP binding site [chemical binding]; other site 1052684006891 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684006892 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684006893 intersubunit interface [polypeptide binding]; other site 1052684006894 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052684006895 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684006896 ABC-ATPase subunit interface; other site 1052684006897 dimer interface [polypeptide binding]; other site 1052684006898 putative PBP binding regions; other site 1052684006899 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052684006900 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684006901 ABC-ATPase subunit interface; other site 1052684006902 dimer interface [polypeptide binding]; other site 1052684006903 putative PBP binding regions; other site 1052684006904 hypothetical protein; Provisional; Region: PRK09739 1052684006905 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052684006906 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684006907 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052684006908 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1052684006909 dimer interface [polypeptide binding]; other site 1052684006910 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052684006911 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1052684006912 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052684006913 RNA binding surface [nucleotide binding]; other site 1052684006914 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1052684006915 probable active site [active] 1052684006916 Spore germination protein; Region: Spore_permease; cl17796 1052684006917 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052684006918 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052684006919 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052684006920 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052684006921 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1052684006922 TAP-like protein; Region: Abhydrolase_4; pfam08386 1052684006923 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684006924 MarR family; Region: MarR_2; pfam12802 1052684006925 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 1052684006926 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1052684006927 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1052684006928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1052684006929 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684006930 S-adenosylmethionine binding site [chemical binding]; other site 1052684006931 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1052684006932 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 1052684006933 VanZ like family; Region: VanZ; pfam04892 1052684006934 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1052684006935 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1052684006936 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 1052684006937 active site 1052684006938 catalytic residues [active] 1052684006939 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052684006940 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1052684006941 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1052684006942 oligomer interface [polypeptide binding]; other site 1052684006943 active site residues [active] 1052684006944 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1052684006945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684006946 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684006947 DNA binding residues [nucleotide binding] 1052684006948 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1052684006949 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 1052684006950 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1052684006951 active site 1052684006952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684006953 Mor transcription activator family; Region: Mor; cl02360 1052684006954 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1052684006955 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1052684006956 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 1052684006957 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 1052684006958 catalytic residues [active] 1052684006959 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 1052684006960 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 1052684006961 Cache domain; Region: Cache_1; pfam02743 1052684006962 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684006963 dimerization interface [polypeptide binding]; other site 1052684006964 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684006965 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684006966 dimer interface [polypeptide binding]; other site 1052684006967 putative CheW interface [polypeptide binding]; other site 1052684006968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684006969 dimer interface [polypeptide binding]; other site 1052684006970 phosphorylation site [posttranslational modification] 1052684006971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684006972 ATP binding site [chemical binding]; other site 1052684006973 Mg2+ binding site [ion binding]; other site 1052684006974 G-X-G motif; other site 1052684006975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684006976 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684006977 active site 1052684006978 phosphorylation site [posttranslational modification] 1052684006979 intermolecular recognition site; other site 1052684006980 dimerization interface [polypeptide binding]; other site 1052684006981 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1052684006982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684006983 active site 1052684006984 phosphorylation site [posttranslational modification] 1052684006985 intermolecular recognition site; other site 1052684006986 dimerization interface [polypeptide binding]; other site 1052684006987 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684006988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684006989 active site 1052684006990 phosphorylation site [posttranslational modification] 1052684006991 intermolecular recognition site; other site 1052684006992 dimerization interface [polypeptide binding]; other site 1052684006993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684006994 DNA binding site [nucleotide binding] 1052684006995 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 1052684006996 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052684006997 inhibitor-cofactor binding pocket; inhibition site 1052684006998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684006999 catalytic residue [active] 1052684007000 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1052684007001 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052684007002 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052684007003 metal binding site [ion binding]; metal-binding site 1052684007004 active site 1052684007005 I-site; other site 1052684007006 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1052684007007 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 1052684007008 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 1052684007009 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 1052684007010 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052684007011 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 1052684007012 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 1052684007013 Cellulose binding domain; Region: CBM_3; pfam00942 1052684007014 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1052684007015 Ferritin-like domain; Region: Ferritin; pfam00210 1052684007016 ferroxidase diiron center [ion binding]; other site 1052684007017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684007018 Coenzyme A binding pocket [chemical binding]; other site 1052684007019 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1052684007020 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1052684007021 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052684007022 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1052684007023 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 1052684007024 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052684007025 acyl-activating enzyme (AAE) consensus motif; other site 1052684007026 AMP binding site [chemical binding]; other site 1052684007027 active site 1052684007028 CoA binding site [chemical binding]; other site 1052684007029 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1052684007030 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1052684007031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684007032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684007033 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 1052684007034 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 1052684007035 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684007036 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684007037 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1052684007038 CPxP motif; other site 1052684007039 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052684007040 active site residue [active] 1052684007041 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1052684007042 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1052684007043 putative homodimer interface [polypeptide binding]; other site 1052684007044 putative homotetramer interface [polypeptide binding]; other site 1052684007045 putative metal binding site [ion binding]; other site 1052684007046 putative homodimer-homodimer interface [polypeptide binding]; other site 1052684007047 putative allosteric switch controlling residues; other site 1052684007048 Predicted membrane protein [Function unknown]; Region: COG2323 1052684007049 Spore germination protein; Region: Spore_permease; cl17796 1052684007050 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052684007051 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052684007052 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052684007053 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1052684007054 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1052684007055 homodimer interface [polypeptide binding]; other site 1052684007056 substrate-cofactor binding pocket; other site 1052684007057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684007058 catalytic residue [active] 1052684007059 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052684007060 Calmodulin-binding; Region: Enkurin; pfam13864 1052684007061 dUMP phosphatase; Provisional; Region: PRK09449 1052684007062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684007063 motif II; other site 1052684007064 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1052684007065 Melibiase; Region: Melibiase; pfam02065 1052684007066 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684007067 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684007068 DNA binding site [nucleotide binding] 1052684007069 domain linker motif; other site 1052684007070 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1052684007071 putative dimerization interface [polypeptide binding]; other site 1052684007072 putative ligand binding site [chemical binding]; other site 1052684007073 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052684007074 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684007075 dimerization interface [polypeptide binding]; other site 1052684007076 Histidine kinase; Region: His_kinase; pfam06580 1052684007077 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684007078 ATP binding site [chemical binding]; other site 1052684007079 Mg2+ binding site [ion binding]; other site 1052684007080 G-X-G motif; other site 1052684007081 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684007082 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684007083 active site 1052684007084 phosphorylation site [posttranslational modification] 1052684007085 intermolecular recognition site; other site 1052684007086 dimerization interface [polypeptide binding]; other site 1052684007087 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684007088 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684007089 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684007090 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684007091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684007092 dimer interface [polypeptide binding]; other site 1052684007093 conserved gate region; other site 1052684007094 putative PBP binding loops; other site 1052684007095 ABC-ATPase subunit interface; other site 1052684007096 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684007097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684007098 dimer interface [polypeptide binding]; other site 1052684007099 conserved gate region; other site 1052684007100 putative PBP binding loops; other site 1052684007101 ABC-ATPase subunit interface; other site 1052684007102 trehalose synthase; Region: treS_nterm; TIGR02456 1052684007103 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 1052684007104 Ca binding site [ion binding]; other site 1052684007105 active site 1052684007106 catalytic site [active] 1052684007107 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1052684007108 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052684007109 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684007110 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052684007111 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 1052684007112 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1052684007113 MarR family; Region: MarR_2; pfam12802 1052684007114 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1052684007115 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1052684007116 active site 1052684007117 FMN binding site [chemical binding]; other site 1052684007118 substrate binding site [chemical binding]; other site 1052684007119 homotetramer interface [polypeptide binding]; other site 1052684007120 catalytic residue [active] 1052684007121 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 1052684007122 Helix-turn-helix domain; Region: HTH_18; pfam12833 1052684007123 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684007124 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1052684007125 classical (c) SDRs; Region: SDR_c; cd05233 1052684007126 NAD(P) binding site [chemical binding]; other site 1052684007127 active site 1052684007128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684007129 putative substrate translocation pore; other site 1052684007130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684007131 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684007132 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684007133 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1052684007134 dimerization interface [polypeptide binding]; other site 1052684007135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684007136 putative substrate translocation pore; other site 1052684007137 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684007138 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684007139 DNA binding site [nucleotide binding] 1052684007140 domain linker motif; other site 1052684007141 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052684007142 dimerization interface [polypeptide binding]; other site 1052684007143 ligand binding site [chemical binding]; other site 1052684007144 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1052684007145 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052684007146 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052684007147 active site 1052684007148 catalytic tetrad [active] 1052684007149 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684007150 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684007151 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684007152 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684007153 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1052684007154 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1052684007155 phosphate binding site [ion binding]; other site 1052684007156 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052684007157 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684007158 DNA-binding site [nucleotide binding]; DNA binding site 1052684007159 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684007160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684007161 homodimer interface [polypeptide binding]; other site 1052684007162 catalytic residue [active] 1052684007163 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1052684007164 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1052684007165 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1052684007166 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684007167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684007168 Coenzyme A binding pocket [chemical binding]; other site 1052684007169 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 1052684007170 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 1052684007171 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1052684007172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684007173 motif II; other site 1052684007174 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1052684007175 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052684007176 NAD(P) binding site [chemical binding]; other site 1052684007177 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052684007178 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 1052684007179 inhibitor-cofactor binding pocket; inhibition site 1052684007180 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684007181 catalytic residue [active] 1052684007182 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1052684007183 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1052684007184 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1052684007185 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1052684007186 mannonate dehydratase; Provisional; Region: PRK03906 1052684007187 mannonate dehydratase; Region: uxuA; TIGR00695 1052684007188 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1052684007189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684007190 DNA-binding site [nucleotide binding]; DNA binding site 1052684007191 FCD domain; Region: FCD; pfam07729 1052684007192 D-mannonate oxidoreductase; Provisional; Region: PRK08277 1052684007193 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684007194 NAD(P) binding site [chemical binding]; other site 1052684007195 active site 1052684007196 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684007197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684007198 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684007199 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684007200 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1052684007201 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1052684007202 inhibitor site; inhibition site 1052684007203 active site 1052684007204 dimer interface [polypeptide binding]; other site 1052684007205 catalytic residue [active] 1052684007206 Predicted membrane protein [Function unknown]; Region: COG2364 1052684007207 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052684007208 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1052684007209 MarR family; Region: MarR_2; pfam12802 1052684007210 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684007211 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684007212 Coenzyme A binding pocket [chemical binding]; other site 1052684007213 amidase; Validated; Region: PRK06565 1052684007214 Amidase; Region: Amidase; cl11426 1052684007215 Amidase; Region: Amidase; cl11426 1052684007216 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 1052684007217 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1052684007218 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1052684007219 Ligand Binding Site [chemical binding]; other site 1052684007220 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1052684007221 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684007222 dimer interface [polypeptide binding]; other site 1052684007223 phosphorylation site [posttranslational modification] 1052684007224 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684007225 ATP binding site [chemical binding]; other site 1052684007226 Mg2+ binding site [ion binding]; other site 1052684007227 G-X-G motif; other site 1052684007228 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684007229 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684007230 active site 1052684007231 phosphorylation site [posttranslational modification] 1052684007232 intermolecular recognition site; other site 1052684007233 dimerization interface [polypeptide binding]; other site 1052684007234 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684007235 DNA binding site [nucleotide binding] 1052684007236 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1052684007237 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052684007238 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1052684007239 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1052684007240 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1052684007241 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 1052684007242 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1052684007243 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1052684007244 putative sugar binding sites [chemical binding]; other site 1052684007245 Q-X-W motif; other site 1052684007246 Nitronate monooxygenase; Region: NMO; pfam03060 1052684007247 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1052684007248 FMN binding site [chemical binding]; other site 1052684007249 substrate binding site [chemical binding]; other site 1052684007250 putative catalytic residue [active] 1052684007251 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052684007252 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684007253 Walker A motif; other site 1052684007254 ATP binding site [chemical binding]; other site 1052684007255 Walker B motif; other site 1052684007256 arginine finger; other site 1052684007257 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 1052684007258 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1052684007259 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1052684007260 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1052684007261 P-loop, Walker A motif; other site 1052684007262 Base recognition motif; other site 1052684007263 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1052684007264 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 1052684007265 Type I GTP cyclohydrolase folE2; Region: GCHY-1; cl00642 1052684007266 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1052684007267 MarR family; Region: MarR_2; pfam12802 1052684007268 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684007269 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684007270 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684007271 Walker A/P-loop; other site 1052684007272 ATP binding site [chemical binding]; other site 1052684007273 Q-loop/lid; other site 1052684007274 ABC transporter signature motif; other site 1052684007275 Walker B; other site 1052684007276 D-loop; other site 1052684007277 H-loop/switch region; other site 1052684007278 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684007279 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684007280 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1052684007281 Walker A/P-loop; other site 1052684007282 ATP binding site [chemical binding]; other site 1052684007283 Q-loop/lid; other site 1052684007284 ABC transporter signature motif; other site 1052684007285 Walker B; other site 1052684007286 D-loop; other site 1052684007287 H-loop/switch region; other site 1052684007288 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1052684007289 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1052684007290 NAD(P) binding site [chemical binding]; other site 1052684007291 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052684007292 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1052684007293 catalytic residues [active] 1052684007294 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1052684007295 classical (c) SDRs; Region: SDR_c; cd05233 1052684007296 NAD(P) binding site [chemical binding]; other site 1052684007297 active site 1052684007298 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1052684007299 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 1052684007300 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684007301 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684007302 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684007303 dimerization interface [polypeptide binding]; other site 1052684007304 putative DNA binding site [nucleotide binding]; other site 1052684007305 putative Zn2+ binding site [ion binding]; other site 1052684007306 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052684007307 active site residue [active] 1052684007308 OsmC-like protein; Region: OsmC; cl00767 1052684007309 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1052684007310 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684007311 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684007312 DNA binding residues [nucleotide binding] 1052684007313 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1052684007314 Condensation domain; Region: Condensation; pfam00668 1052684007315 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007316 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684007317 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684007318 acyl-activating enzyme (AAE) consensus motif; other site 1052684007319 AMP binding site [chemical binding]; other site 1052684007320 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007321 Condensation domain; Region: Condensation; pfam00668 1052684007322 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007323 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684007324 Condensation domain; Region: Condensation; pfam00668 1052684007325 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007326 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052684007327 acyl-activating enzyme (AAE) consensus motif; other site 1052684007328 AMP binding site [chemical binding]; other site 1052684007329 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007330 Condensation domain; Region: Condensation; pfam00668 1052684007331 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007332 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684007333 Condensation domain; Region: Condensation; pfam00668 1052684007334 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007335 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684007336 acyl-activating enzyme (AAE) consensus motif; other site 1052684007337 AMP binding site [chemical binding]; other site 1052684007338 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007339 Condensation domain; Region: Condensation; pfam00668 1052684007340 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007341 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684007342 Condensation domain; Region: Condensation; pfam00668 1052684007343 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007344 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684007345 acyl-activating enzyme (AAE) consensus motif; other site 1052684007346 AMP binding site [chemical binding]; other site 1052684007347 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007348 Condensation domain; Region: Condensation; pfam00668 1052684007349 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007350 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684007351 Condensation domain; Region: Condensation; pfam00668 1052684007352 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007353 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684007354 acyl-activating enzyme (AAE) consensus motif; other site 1052684007355 AMP binding site [chemical binding]; other site 1052684007356 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007357 Condensation domain; Region: Condensation; pfam00668 1052684007358 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007359 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684007360 Condensation domain; Region: Condensation; pfam00668 1052684007361 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007362 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684007363 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684007364 acyl-activating enzyme (AAE) consensus motif; other site 1052684007365 AMP binding site [chemical binding]; other site 1052684007366 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007367 Condensation domain; Region: Condensation; pfam00668 1052684007368 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007369 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684007370 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052684007371 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684007372 acyl-activating enzyme (AAE) consensus motif; other site 1052684007373 AMP binding site [chemical binding]; other site 1052684007374 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007375 Condensation domain; Region: Condensation; pfam00668 1052684007376 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007377 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684007378 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052684007379 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1052684007380 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684007381 acyl-activating enzyme (AAE) consensus motif; other site 1052684007382 AMP binding site [chemical binding]; other site 1052684007383 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007384 Condensation domain; Region: Condensation; pfam00668 1052684007385 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007386 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684007387 Condensation domain; Region: Condensation; pfam00668 1052684007388 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007389 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052684007390 acyl-activating enzyme (AAE) consensus motif; other site 1052684007391 AMP binding site [chemical binding]; other site 1052684007392 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007393 Condensation domain; Region: Condensation; pfam00668 1052684007394 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007395 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684007396 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684007397 acyl-activating enzyme (AAE) consensus motif; other site 1052684007398 AMP binding site [chemical binding]; other site 1052684007399 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007400 Condensation domain; Region: Condensation; pfam00668 1052684007401 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007402 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684007403 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 1052684007404 substrate binding site [chemical binding]; other site 1052684007405 active site 1052684007406 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1052684007407 metal binding site [ion binding]; metal-binding site 1052684007408 ligand binding site [chemical binding]; other site 1052684007409 Carbohydrate Binding Module families 36 (CBM36) and 6 (CBM6); appended mainly to glycoside hydrolase family 11 (GH11) domains; xylan binding; Region: CBM6_36_xylanase-like; cd04078 1052684007410 Ca binding site [ion binding]; other site 1052684007411 Ca binding site (active) [ion binding]; other site 1052684007412 ligand binding site [chemical binding]; other site 1052684007413 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 1052684007414 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 1052684007415 active site 1052684007416 active site 1052684007417 catalytic residues [active] 1052684007418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684007419 Coenzyme A binding pocket [chemical binding]; other site 1052684007420 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1052684007421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684007422 active site 1052684007423 phosphorylation site [posttranslational modification] 1052684007424 intermolecular recognition site; other site 1052684007425 dimerization interface [polypeptide binding]; other site 1052684007426 LytTr DNA-binding domain; Region: LytTR; pfam04397 1052684007427 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 1052684007428 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052684007429 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052684007430 Beta-lactamase; Region: Beta-lactamase; pfam00144 1052684007431 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684007432 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684007433 DNA binding site [nucleotide binding] 1052684007434 domain linker motif; other site 1052684007435 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1052684007436 dimerization interface [polypeptide binding]; other site 1052684007437 ligand binding site [chemical binding]; other site 1052684007438 sodium binding site [ion binding]; other site 1052684007439 galactoside permease; Reviewed; Region: lacY; PRK09528 1052684007440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684007441 putative substrate translocation pore; other site 1052684007442 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1052684007443 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052684007444 substrate binding [chemical binding]; other site 1052684007445 active site 1052684007446 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052684007447 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684007448 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684007449 DNA binding site [nucleotide binding] 1052684007450 domain linker motif; other site 1052684007451 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052684007452 dimerization interface [polypeptide binding]; other site 1052684007453 ligand binding site [chemical binding]; other site 1052684007454 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1052684007455 MFS/sugar transport protein; Region: MFS_2; pfam13347 1052684007456 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1052684007457 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052684007458 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1052684007459 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 1052684007460 acyl-activating enzyme (AAE) consensus motif; other site 1052684007461 putative AMP binding site [chemical binding]; other site 1052684007462 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007463 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08722 1052684007464 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684007465 active site 1052684007466 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007467 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 1052684007468 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052684007469 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052684007470 catalytic residue [active] 1052684007471 Condensation domain; Region: Condensation; pfam00668 1052684007472 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007473 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684007474 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052684007475 CoA binding site [chemical binding]; other site 1052684007476 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007477 Condensation domain; Region: Condensation; pfam00668 1052684007478 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007479 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684007480 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684007481 acyl-activating enzyme (AAE) consensus motif; other site 1052684007482 AMP binding site [chemical binding]; other site 1052684007483 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007484 Condensation domain; Region: Condensation; pfam00668 1052684007485 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684007486 Condensation domain; Region: Condensation; pfam00668 1052684007487 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007488 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684007489 acyl-activating enzyme (AAE) consensus motif; other site 1052684007490 AMP binding site [chemical binding]; other site 1052684007491 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007492 Condensation domain; Region: Condensation; pfam00668 1052684007493 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684007494 Condensation domain; Region: Condensation; pfam00668 1052684007495 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007496 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052684007497 acyl-activating enzyme (AAE) consensus motif; other site 1052684007498 AMP binding site [chemical binding]; other site 1052684007499 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007500 Condensation domain; Region: Condensation; pfam00668 1052684007501 muropeptide transporter; Validated; Region: ampG; cl17669 1052684007502 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684007503 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684007504 active site 1052684007505 phosphorylation site [posttranslational modification] 1052684007506 intermolecular recognition site; other site 1052684007507 dimerization interface [polypeptide binding]; other site 1052684007508 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684007509 DNA binding site [nucleotide binding] 1052684007510 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684007511 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684007512 dimerization interface [polypeptide binding]; other site 1052684007513 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684007514 dimer interface [polypeptide binding]; other site 1052684007515 phosphorylation site [posttranslational modification] 1052684007516 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684007517 ATP binding site [chemical binding]; other site 1052684007518 Mg2+ binding site [ion binding]; other site 1052684007519 G-X-G motif; other site 1052684007520 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1052684007521 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1052684007522 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684007523 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684007524 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684007525 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684007526 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1052684007527 putative dimerization interface [polypeptide binding]; other site 1052684007528 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052684007529 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1052684007530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684007531 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684007532 putative substrate translocation pore; other site 1052684007533 glutamate racemase; Provisional; Region: PRK00865 1052684007534 Tautomerase enzyme; Region: Tautomerase; pfam01361 1052684007535 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052684007536 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1052684007537 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1052684007538 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1052684007539 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684007540 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052684007541 active site 1052684007542 motif I; other site 1052684007543 motif II; other site 1052684007544 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1052684007545 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052684007546 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1052684007547 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684007548 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1052684007549 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1052684007550 inhibitor site; inhibition site 1052684007551 active site 1052684007552 dimer interface [polypeptide binding]; other site 1052684007553 catalytic residue [active] 1052684007554 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684007555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684007556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684007557 dimerization interface [polypeptide binding]; other site 1052684007558 Major royal jelly protein; Region: MRJP; pfam03022 1052684007559 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1052684007560 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1052684007561 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1052684007562 putative NAD(P) binding site [chemical binding]; other site 1052684007563 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052684007564 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052684007565 Spore germination protein; Region: Spore_permease; cl17796 1052684007566 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052684007567 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 1052684007568 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684007569 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1052684007570 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1052684007571 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1052684007572 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1052684007573 acetoacetate decarboxylase; Provisional; Region: PRK02265 1052684007574 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684007575 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684007576 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684007577 dimerization interface [polypeptide binding]; other site 1052684007578 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1052684007579 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052684007580 Beta-lactamase; Region: Beta-lactamase; pfam00144 1052684007581 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1052684007582 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 1052684007583 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1052684007584 S-layer homology domain; Region: SLH; pfam00395 1052684007585 S-layer homology domain; Region: SLH; pfam00395 1052684007586 Protein of unknown function (DUF421); Region: DUF421; pfam04239 1052684007587 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1052684007588 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1052684007589 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684007590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684007591 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1052684007592 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684007593 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684007594 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684007595 beta-D-glucuronidase; Provisional; Region: PRK10150 1052684007596 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1052684007597 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1052684007598 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1052684007599 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1052684007600 MarR family; Region: MarR_2; pfam12802 1052684007601 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1052684007602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684007603 Coenzyme A binding pocket [chemical binding]; other site 1052684007604 LamG-like jellyroll fold domain; Region: LamGL; smart00560 1052684007605 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1052684007606 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052684007607 substrate binding [chemical binding]; other site 1052684007608 active site 1052684007609 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052684007610 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1052684007611 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1052684007612 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052684007613 substrate binding [chemical binding]; other site 1052684007614 active site 1052684007615 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052684007616 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052684007617 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1052684007618 putative substrate binding site [chemical binding]; other site 1052684007619 putative ATP binding site [chemical binding]; other site 1052684007620 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1052684007621 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052684007622 substrate binding [chemical binding]; other site 1052684007623 active site 1052684007624 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052684007625 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684007626 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684007627 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684007628 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684007629 dimer interface [polypeptide binding]; other site 1052684007630 conserved gate region; other site 1052684007631 putative PBP binding loops; other site 1052684007632 ABC-ATPase subunit interface; other site 1052684007633 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684007634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684007635 dimer interface [polypeptide binding]; other site 1052684007636 conserved gate region; other site 1052684007637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1052684007638 ABC-ATPase subunit interface; other site 1052684007639 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684007640 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684007641 DNA binding site [nucleotide binding] 1052684007642 domain linker motif; other site 1052684007643 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1052684007644 dimerization interface [polypeptide binding]; other site 1052684007645 ligand binding site [chemical binding]; other site 1052684007646 sodium binding site [ion binding]; other site 1052684007647 Penicillinase repressor; Region: Pencillinase_R; cl17580 1052684007648 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1052684007649 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1052684007650 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684007651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684007652 putative substrate translocation pore; other site 1052684007653 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1052684007654 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1052684007655 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052684007656 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052684007657 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 1052684007658 NodB motif; other site 1052684007659 putative active site [active] 1052684007660 putative catalytic site [active] 1052684007661 putative Zn binding site [ion binding]; other site 1052684007662 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 1052684007663 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 1052684007664 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052684007665 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1052684007666 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1052684007667 active site 1052684007668 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1052684007669 Predicted membrane protein [Function unknown]; Region: COG1238 1052684007670 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1052684007671 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1052684007672 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1052684007673 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684007674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684007675 conserved gate region; other site 1052684007676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1052684007677 ABC-ATPase subunit interface; other site 1052684007678 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684007679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684007680 dimer interface [polypeptide binding]; other site 1052684007681 conserved gate region; other site 1052684007682 ABC-ATPase subunit interface; other site 1052684007683 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684007684 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1052684007685 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684007686 active site 1052684007687 phosphorylation site [posttranslational modification] 1052684007688 intermolecular recognition site; other site 1052684007689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684007690 Histidine kinase; Region: His_kinase; pfam06580 1052684007691 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684007692 ATP binding site [chemical binding]; other site 1052684007693 Mg2+ binding site [ion binding]; other site 1052684007694 G-X-G motif; other site 1052684007695 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 1052684007696 Right handed beta helix region; Region: Beta_helix; pfam13229 1052684007697 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052684007698 dimer interface [polypeptide binding]; other site 1052684007699 FMN binding site [chemical binding]; other site 1052684007700 Rrf2 family protein; Region: rrf2_super; TIGR00738 1052684007701 Transcriptional regulator; Region: Rrf2; pfam02082 1052684007702 Transcriptional regulator; Region: Rrf2; cl17282 1052684007703 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1052684007704 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1052684007705 sugar binding site [chemical binding]; other site 1052684007706 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684007707 Interdomain contacts; other site 1052684007708 Cytokine receptor motif; other site 1052684007709 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 1052684007710 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 1052684007711 putative sugar binding sites [chemical binding]; other site 1052684007712 Q-X-W motif; other site 1052684007713 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684007714 Interdomain contacts; other site 1052684007715 Cytokine receptor motif; other site 1052684007716 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1052684007717 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 1052684007718 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052684007719 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684007720 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1052684007721 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052684007722 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684007723 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052684007724 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684007725 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684007726 DNA binding site [nucleotide binding] 1052684007727 domain linker motif; other site 1052684007728 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052684007729 ligand binding site [chemical binding]; other site 1052684007730 dimerization interface [polypeptide binding]; other site 1052684007731 Sugar transport protein; Region: Sugar_transport; pfam06800 1052684007732 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1052684007733 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1052684007734 Melibiase; Region: Melibiase; pfam02065 1052684007735 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684007736 active site 1052684007737 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052684007738 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684007739 putative oxidoreductase; Provisional; Region: PRK10206 1052684007740 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684007741 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052684007742 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1052684007743 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1052684007744 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1052684007745 putative active site [active] 1052684007746 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684007747 dimerization interface [polypeptide binding]; other site 1052684007748 putative DNA binding site [nucleotide binding]; other site 1052684007749 putative Zn2+ binding site [ion binding]; other site 1052684007750 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052684007751 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684007752 putative substrate translocation pore; other site 1052684007753 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1052684007754 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1052684007755 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1052684007756 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1052684007757 Walker A/P-loop; other site 1052684007758 ATP binding site [chemical binding]; other site 1052684007759 Q-loop/lid; other site 1052684007760 ABC transporter signature motif; other site 1052684007761 Walker B; other site 1052684007762 D-loop; other site 1052684007763 H-loop/switch region; other site 1052684007764 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1052684007765 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052684007766 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1052684007767 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684007768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684007769 active site 1052684007770 phosphorylation site [posttranslational modification] 1052684007771 intermolecular recognition site; other site 1052684007772 dimerization interface [polypeptide binding]; other site 1052684007773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684007774 DNA binding site [nucleotide binding] 1052684007775 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684007776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684007777 dimer interface [polypeptide binding]; other site 1052684007778 phosphorylation site [posttranslational modification] 1052684007779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684007780 ATP binding site [chemical binding]; other site 1052684007781 Mg2+ binding site [ion binding]; other site 1052684007782 G-X-G motif; other site 1052684007783 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684007784 Interdomain contacts; other site 1052684007785 Cytokine receptor motif; other site 1052684007786 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684007787 integral membrane protein; Region: integ_memb_HG; TIGR03954 1052684007788 YolD-like protein; Region: YolD; pfam08863 1052684007789 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684007790 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684007791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684007792 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1052684007793 putative substrate translocation pore; other site 1052684007794 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1052684007795 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1052684007796 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1052684007797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684007798 dimer interface [polypeptide binding]; other site 1052684007799 conserved gate region; other site 1052684007800 putative PBP binding loops; other site 1052684007801 ABC-ATPase subunit interface; other site 1052684007802 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052684007803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684007804 dimer interface [polypeptide binding]; other site 1052684007805 conserved gate region; other site 1052684007806 putative PBP binding loops; other site 1052684007807 ABC-ATPase subunit interface; other site 1052684007808 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1052684007809 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052684007810 Walker A/P-loop; other site 1052684007811 ATP binding site [chemical binding]; other site 1052684007812 Q-loop/lid; other site 1052684007813 ABC transporter signature motif; other site 1052684007814 Walker B; other site 1052684007815 D-loop; other site 1052684007816 H-loop/switch region; other site 1052684007817 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052684007818 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1052684007819 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052684007820 Walker A/P-loop; other site 1052684007821 ATP binding site [chemical binding]; other site 1052684007822 Q-loop/lid; other site 1052684007823 ABC transporter signature motif; other site 1052684007824 Walker B; other site 1052684007825 D-loop; other site 1052684007826 H-loop/switch region; other site 1052684007827 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1052684007828 putative efflux protein, MATE family; Region: matE; TIGR00797 1052684007829 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1052684007830 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1052684007831 tetramer interface [polypeptide binding]; other site 1052684007832 heme binding pocket [chemical binding]; other site 1052684007833 NADPH binding site [chemical binding]; other site 1052684007834 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1052684007835 AAA domain; Region: AAA_33; pfam13671 1052684007836 ligand-binding site [chemical binding]; other site 1052684007837 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295 1052684007838 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 1052684007839 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 1052684007840 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1052684007841 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1052684007842 nudix motif; other site 1052684007843 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684007844 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1052684007845 acyl-activating enzyme (AAE) consensus motif; other site 1052684007846 AMP binding site [chemical binding]; other site 1052684007847 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007848 Condensation domain; Region: Condensation; pfam00668 1052684007849 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007850 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684007851 Condensation domain; Region: Condensation; pfam00668 1052684007852 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052684007853 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1052684007854 acyl-activating enzyme (AAE) consensus motif; other site 1052684007855 AMP binding site [chemical binding]; other site 1052684007856 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007857 Condensation domain; Region: Condensation; pfam00668 1052684007858 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684007859 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684007860 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052684007861 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1052684007862 acyl-activating enzyme (AAE) consensus motif; other site 1052684007863 AMP binding site [chemical binding]; other site 1052684007864 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684007865 Condensation domain; Region: Condensation; pfam00668 1052684007866 glutaminase A; Region: Gln_ase; TIGR03814 1052684007867 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1052684007868 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 1052684007869 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 1052684007870 putative metal binding site [ion binding]; other site 1052684007871 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1052684007872 active site 1052684007873 Predicted membrane protein [Function unknown]; Region: COG2259 1052684007874 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1052684007875 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684007876 non-specific DNA binding site [nucleotide binding]; other site 1052684007877 salt bridge; other site 1052684007878 sequence-specific DNA binding site [nucleotide binding]; other site 1052684007879 Cupin domain; Region: Cupin_2; pfam07883 1052684007880 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684007881 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1052684007882 potassium/proton antiporter; Reviewed; Region: PRK05326 1052684007883 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1052684007884 TrkA-C domain; Region: TrkA_C; pfam02080 1052684007885 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1052684007886 Class II fumarases; Region: Fumarase_classII; cd01362 1052684007887 active site 1052684007888 tetramer interface [polypeptide binding]; other site 1052684007889 2-isopropylmalate synthase; Validated; Region: PRK00915 1052684007890 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1052684007891 active site 1052684007892 catalytic residues [active] 1052684007893 metal binding site [ion binding]; metal-binding site 1052684007894 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1052684007895 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1052684007896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684007897 DNA-binding site [nucleotide binding]; DNA binding site 1052684007898 FCD domain; Region: FCD; pfam07729 1052684007899 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1052684007900 active site 1052684007901 catalytic residues [active] 1052684007902 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052684007903 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1052684007904 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1052684007905 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1052684007906 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1052684007907 dimer interface [polypeptide binding]; other site 1052684007908 active site 1052684007909 metal binding site [ion binding]; metal-binding site 1052684007910 biotin synthase; Validated; Region: PRK06256 1052684007911 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684007912 FeS/SAM binding site; other site 1052684007913 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1052684007914 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052684007915 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052684007916 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052684007917 Transporter associated domain; Region: CorC_HlyC; smart01091 1052684007918 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 1052684007919 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052684007920 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1052684007921 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684007922 NAD(P) binding site [chemical binding]; other site 1052684007923 active site 1052684007924 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1052684007925 Ycf48-like protein; Provisional; Region: PRK13684 1052684007926 Ycf48-like protein; Provisional; Region: PRK13684 1052684007927 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1052684007928 amino acid transporter; Region: 2A0306; TIGR00909 1052684007929 Spore germination protein; Region: Spore_permease; cl17796 1052684007930 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1052684007931 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1052684007932 NAD binding site [chemical binding]; other site 1052684007933 dimer interface [polypeptide binding]; other site 1052684007934 substrate binding site [chemical binding]; other site 1052684007935 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052684007936 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 1052684007937 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 1052684007938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684007939 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052684007940 putative substrate translocation pore; other site 1052684007941 MutS domain III; Region: MutS_III; pfam05192 1052684007942 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 1052684007943 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684007944 Walker A/P-loop; other site 1052684007945 ATP binding site [chemical binding]; other site 1052684007946 Q-loop/lid; other site 1052684007947 ABC transporter signature motif; other site 1052684007948 Walker B; other site 1052684007949 D-loop; other site 1052684007950 H-loop/switch region; other site 1052684007951 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1052684007952 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052684007953 nucleotide binding site [chemical binding]; other site 1052684007954 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1052684007955 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684007956 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1052684007957 active site 1052684007958 motif I; other site 1052684007959 motif II; other site 1052684007960 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1052684007961 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1052684007962 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1052684007963 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1052684007964 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1052684007965 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052684007966 active site 1052684007967 DNA binding site [nucleotide binding] 1052684007968 Int/Topo IB signature motif; other site 1052684007969 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052684007970 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052684007971 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684007972 ABC-ATPase subunit interface; other site 1052684007973 dimer interface [polypeptide binding]; other site 1052684007974 putative PBP binding regions; other site 1052684007975 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052684007976 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684007977 ABC-ATPase subunit interface; other site 1052684007978 dimer interface [polypeptide binding]; other site 1052684007979 putative PBP binding regions; other site 1052684007980 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684007981 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684007982 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684007983 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684007984 intersubunit interface [polypeptide binding]; other site 1052684007985 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684007986 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684007987 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1052684007988 Walker A/P-loop; other site 1052684007989 ATP binding site [chemical binding]; other site 1052684007990 Q-loop/lid; other site 1052684007991 ABC transporter signature motif; other site 1052684007992 Walker B; other site 1052684007993 D-loop; other site 1052684007994 H-loop/switch region; other site 1052684007995 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684007996 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684007997 intersubunit interface [polypeptide binding]; other site 1052684007998 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1052684007999 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1052684008000 ligand binding site [chemical binding]; other site 1052684008001 dimerization interface [polypeptide binding]; other site 1052684008002 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1052684008003 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1052684008004 TM-ABC transporter signature motif; other site 1052684008005 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1052684008006 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1052684008007 Walker A/P-loop; other site 1052684008008 ATP binding site [chemical binding]; other site 1052684008009 Q-loop/lid; other site 1052684008010 ABC transporter signature motif; other site 1052684008011 Walker B; other site 1052684008012 D-loop; other site 1052684008013 H-loop/switch region; other site 1052684008014 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1052684008015 D-ribose pyranase; Provisional; Region: PRK11797 1052684008016 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052684008017 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1052684008018 substrate binding site [chemical binding]; other site 1052684008019 dimer interface [polypeptide binding]; other site 1052684008020 ATP binding site [chemical binding]; other site 1052684008021 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684008022 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684008023 DNA binding site [nucleotide binding] 1052684008024 domain linker motif; other site 1052684008025 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052684008026 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 1052684008027 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 1052684008028 catalytic residues [active] 1052684008029 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1052684008030 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 1052684008031 putative NAD(P) binding site [chemical binding]; other site 1052684008032 putative active site [active] 1052684008033 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684008034 Predicted permeases [General function prediction only]; Region: COG0679 1052684008035 BNR repeat-like domain; Region: BNR_2; pfam13088 1052684008036 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 1052684008037 Cellulose binding domain; Region: CBM_3; pfam00942 1052684008038 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052684008039 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1052684008040 metal binding site [ion binding]; metal-binding site 1052684008041 dimer interface [polypeptide binding]; other site 1052684008042 Predicted acetyltransferase [General function prediction only]; Region: COG5628 1052684008043 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1052684008044 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052684008045 active site 1052684008046 DNA binding site [nucleotide binding] 1052684008047 Int/Topo IB signature motif; other site 1052684008048 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 1052684008049 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1052684008050 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1052684008051 dimer interface [polypeptide binding]; other site 1052684008052 putative functional site; other site 1052684008053 putative MPT binding site; other site 1052684008054 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684008055 non-specific DNA binding site [nucleotide binding]; other site 1052684008056 salt bridge; other site 1052684008057 sequence-specific DNA binding site [nucleotide binding]; other site 1052684008058 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 1052684008059 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 1052684008060 Predicted membrane protein [Function unknown]; Region: COG3766 1052684008061 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1052684008062 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1052684008063 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1052684008064 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1052684008065 active site 1052684008066 FMN binding site [chemical binding]; other site 1052684008067 substrate binding site [chemical binding]; other site 1052684008068 homotetramer interface [polypeptide binding]; other site 1052684008069 catalytic residue [active] 1052684008070 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 1052684008071 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1052684008072 NodB motif; other site 1052684008073 active site 1052684008074 catalytic site [active] 1052684008075 metal binding site [ion binding]; metal-binding site 1052684008076 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052684008077 3D domain; Region: 3D; cl01439 1052684008078 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052684008079 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052684008080 Walker A/P-loop; other site 1052684008081 ATP binding site [chemical binding]; other site 1052684008082 Q-loop/lid; other site 1052684008083 ABC transporter signature motif; other site 1052684008084 Walker B; other site 1052684008085 D-loop; other site 1052684008086 H-loop/switch region; other site 1052684008087 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052684008088 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052684008089 substrate binding pocket [chemical binding]; other site 1052684008090 membrane-bound complex binding site; other site 1052684008091 hinge residues; other site 1052684008092 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052684008093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684008094 dimer interface [polypeptide binding]; other site 1052684008095 conserved gate region; other site 1052684008096 putative PBP binding loops; other site 1052684008097 ABC-ATPase subunit interface; other site 1052684008098 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052684008099 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 1052684008100 metal binding site [ion binding]; metal-binding site 1052684008101 Uncharacterized conserved protein [Function unknown]; Region: COG4278 1052684008102 glycogen synthase; Provisional; Region: glgA; PRK00654 1052684008103 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1052684008104 ADP-binding pocket [chemical binding]; other site 1052684008105 homodimer interface [polypeptide binding]; other site 1052684008106 glycogen branching enzyme; Provisional; Region: PRK12313 1052684008107 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1052684008108 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1052684008109 active site 1052684008110 catalytic site [active] 1052684008111 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1052684008112 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1052684008113 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1052684008114 ligand binding site; other site 1052684008115 oligomer interface; other site 1052684008116 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1052684008117 dimer interface [polypeptide binding]; other site 1052684008118 N-terminal domain interface [polypeptide binding]; other site 1052684008119 sulfate 1 binding site; other site 1052684008120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684008121 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684008122 dimerization interface [polypeptide binding]; other site 1052684008123 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684008124 dimer interface [polypeptide binding]; other site 1052684008125 phosphorylation site [posttranslational modification] 1052684008126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684008127 ATP binding site [chemical binding]; other site 1052684008128 Mg2+ binding site [ion binding]; other site 1052684008129 G-X-G motif; other site 1052684008130 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684008131 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684008132 active site 1052684008133 phosphorylation site [posttranslational modification] 1052684008134 intermolecular recognition site; other site 1052684008135 dimerization interface [polypeptide binding]; other site 1052684008136 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684008137 DNA binding site [nucleotide binding] 1052684008138 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1052684008139 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684008140 Walker A/P-loop; other site 1052684008141 ATP binding site [chemical binding]; other site 1052684008142 Q-loop/lid; other site 1052684008143 ABC transporter signature motif; other site 1052684008144 Walker B; other site 1052684008145 D-loop; other site 1052684008146 H-loop/switch region; other site 1052684008147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684008148 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684008149 putative substrate translocation pore; other site 1052684008150 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1052684008151 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684008152 motif II; other site 1052684008153 DNA topoisomerase III; Provisional; Region: PRK07726 1052684008154 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1052684008155 active site 1052684008156 putative interdomain interaction site [polypeptide binding]; other site 1052684008157 putative metal-binding site [ion binding]; other site 1052684008158 putative nucleotide binding site [chemical binding]; other site 1052684008159 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1052684008160 domain I; other site 1052684008161 DNA binding groove [nucleotide binding] 1052684008162 phosphate binding site [ion binding]; other site 1052684008163 domain II; other site 1052684008164 domain III; other site 1052684008165 nucleotide binding site [chemical binding]; other site 1052684008166 catalytic site [active] 1052684008167 domain IV; other site 1052684008168 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1052684008169 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1052684008170 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684008171 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052684008172 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1052684008173 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1052684008174 folate binding site [chemical binding]; other site 1052684008175 NADP+ binding site [chemical binding]; other site 1052684008176 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1052684008177 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1052684008178 dimerization interface [polypeptide binding]; other site 1052684008179 active site 1052684008180 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1052684008181 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1052684008182 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684008183 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052684008184 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052684008185 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11855 1052684008186 E3 interaction surface; other site 1052684008187 lipoyl attachment site [posttranslational modification]; other site 1052684008188 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052684008189 E3 interaction surface; other site 1052684008190 lipoyl attachment site [posttranslational modification]; other site 1052684008191 e3 binding domain; Region: E3_binding; pfam02817 1052684008192 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1052684008193 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1052684008194 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1052684008195 alpha subunit interface [polypeptide binding]; other site 1052684008196 TPP binding site [chemical binding]; other site 1052684008197 heterodimer interface [polypeptide binding]; other site 1052684008198 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052684008199 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 1052684008200 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1052684008201 TPP-binding site [chemical binding]; other site 1052684008202 heterodimer interface [polypeptide binding]; other site 1052684008203 tetramer interface [polypeptide binding]; other site 1052684008204 phosphorylation loop region [posttranslational modification] 1052684008205 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1052684008206 Putative esterase; Region: Esterase; pfam00756 1052684008207 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1052684008208 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052684008209 active site 1052684008210 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1052684008211 Thiamine pyrophosphokinase; Region: TPK; cd07995 1052684008212 active site 1052684008213 dimerization interface [polypeptide binding]; other site 1052684008214 thiamine binding site [chemical binding]; other site 1052684008215 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052684008216 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684008217 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684008218 active site 1052684008219 phosphorylation site [posttranslational modification] 1052684008220 intermolecular recognition site; other site 1052684008221 dimerization interface [polypeptide binding]; other site 1052684008222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684008223 DNA binding site [nucleotide binding] 1052684008224 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1052684008225 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1052684008226 ATP binding site [chemical binding]; other site 1052684008227 substrate interface [chemical binding]; other site 1052684008228 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1052684008229 ThiS interaction site; other site 1052684008230 putative active site [active] 1052684008231 tetramer interface [polypeptide binding]; other site 1052684008232 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1052684008233 thiS-thiF/thiG interaction site; other site 1052684008234 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 1052684008235 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1052684008236 active site 1052684008237 thiamine phosphate binding site [chemical binding]; other site 1052684008238 pyrophosphate binding site [ion binding]; other site 1052684008239 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052684008240 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684008241 Walker A/P-loop; other site 1052684008242 ATP binding site [chemical binding]; other site 1052684008243 Q-loop/lid; other site 1052684008244 ABC transporter signature motif; other site 1052684008245 Walker B; other site 1052684008246 D-loop; other site 1052684008247 H-loop/switch region; other site 1052684008248 ABC transporter; Region: ABC_tran_2; pfam12848 1052684008249 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052684008250 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 1052684008251 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1052684008252 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1052684008253 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 1052684008254 putative active site [active] 1052684008255 putative NTP binding site [chemical binding]; other site 1052684008256 putative nucleic acid binding site [nucleotide binding]; other site 1052684008257 putative transposase OrfB; Reviewed; Region: PHA02517 1052684008258 HTH-like domain; Region: HTH_21; pfam13276 1052684008259 Integrase core domain; Region: rve; pfam00665 1052684008260 Integrase core domain; Region: rve_2; pfam13333 1052684008261 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1052684008262 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1052684008263 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684008264 non-specific DNA binding site [nucleotide binding]; other site 1052684008265 salt bridge; other site 1052684008266 sequence-specific DNA binding site [nucleotide binding]; other site 1052684008267 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1052684008268 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1052684008269 active site 1052684008270 S-layer homology domain; Region: SLH; pfam00395 1052684008271 Holin family; Region: Phage_holin_4; pfam05105 1052684008272 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1052684008273 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1052684008274 Baseplate J-like protein; Region: Baseplate_J; pfam04865 1052684008275 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1052684008276 Phage-related minor tail protein [Function unknown]; Region: COG5280 1052684008277 Phage XkdN-like protein; Region: XkdN; pfam08890 1052684008278 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1052684008279 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1052684008280 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 1052684008281 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 1052684008282 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1052684008283 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1052684008284 Terminase-like family; Region: Terminase_6; pfam03237 1052684008285 large terminase protein; Provisional; Region: 17; PHA02533 1052684008286 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1052684008287 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1052684008288 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1052684008289 ParB-like nuclease domain; Region: ParB; smart00470 1052684008290 RNA polymerase sigma-70 factor, sigma-B/F/G subfamily; Region: SigBFG; TIGR02980 1052684008291 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684008292 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052684008293 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 1052684008294 active site 1052684008295 putative DNA-binding cleft [nucleotide binding]; other site 1052684008296 dimer interface [polypeptide binding]; other site 1052684008297 replicative DNA helicase; Region: DnaB; TIGR00665 1052684008298 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1052684008299 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1052684008300 Walker A motif; other site 1052684008301 ATP binding site [chemical binding]; other site 1052684008302 Walker B motif; other site 1052684008303 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 1052684008304 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1052684008305 RecT family; Region: RecT; cl04285 1052684008306 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1052684008307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684008308 non-specific DNA binding site [nucleotide binding]; other site 1052684008309 salt bridge; other site 1052684008310 sequence-specific DNA binding site [nucleotide binding]; other site 1052684008311 Helix-turn-helix domain; Region: HTH_17; cl17695 1052684008312 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1052684008313 non-specific DNA binding site [nucleotide binding]; other site 1052684008314 sequence-specific DNA binding site [nucleotide binding]; other site 1052684008315 salt bridge; other site 1052684008316 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 1052684008317 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1052684008318 Int/Topo IB signature motif; other site 1052684008319 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1052684008320 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1052684008321 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1052684008322 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1052684008323 active site 1052684008324 ATP binding site [chemical binding]; other site 1052684008325 substrate binding site [chemical binding]; other site 1052684008326 activation loop (A-loop); other site 1052684008327 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2933 1052684008328 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684008329 S-adenosylmethionine binding site [chemical binding]; other site 1052684008330 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052684008331 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1052684008332 Walker A/P-loop; other site 1052684008333 ATP binding site [chemical binding]; other site 1052684008334 Q-loop/lid; other site 1052684008335 ABC transporter signature motif; other site 1052684008336 Walker B; other site 1052684008337 D-loop; other site 1052684008338 H-loop/switch region; other site 1052684008339 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052684008340 catalytic residues [active] 1052684008341 AP endonuclease family 2; Region: AP2Ec; smart00518 1052684008342 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1052684008343 AP (apurinic/apyrimidinic) site pocket; other site 1052684008344 DNA interaction; other site 1052684008345 Metal-binding active site; metal-binding site 1052684008346 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1052684008347 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1052684008348 DNA binding site [nucleotide binding] 1052684008349 catalytic residue [active] 1052684008350 H2TH interface [polypeptide binding]; other site 1052684008351 putative catalytic residues [active] 1052684008352 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1052684008353 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1052684008354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684008355 active site 1052684008356 motif I; other site 1052684008357 motif II; other site 1052684008358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684008359 ribonuclease Z; Region: RNase_Z; TIGR02651 1052684008360 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 1052684008361 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1052684008362 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1052684008363 substrate binding pocket [chemical binding]; other site 1052684008364 dimer interface [polypeptide binding]; other site 1052684008365 inhibitor binding site; inhibition site 1052684008366 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1052684008367 B12 binding site [chemical binding]; other site 1052684008368 cobalt ligand [ion binding]; other site 1052684008369 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1052684008370 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 1052684008371 Cupin domain; Region: Cupin_2; pfam07883 1052684008372 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1052684008373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684008374 motif II; other site 1052684008375 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 1052684008376 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052684008377 LexA repressor; Validated; Region: PRK00215 1052684008378 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684008379 putative DNA binding site [nucleotide binding]; other site 1052684008380 putative Zn2+ binding site [ion binding]; other site 1052684008381 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1052684008382 Catalytic site [active] 1052684008383 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 1052684008384 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1052684008385 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052684008386 active site 1052684008387 L-aspartate oxidase; Provisional; Region: PRK06175 1052684008388 FAD binding domain; Region: FAD_binding_2; pfam00890 1052684008389 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1052684008390 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1052684008391 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1052684008392 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 1052684008393 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684008394 Interdomain contacts; other site 1052684008395 Cytokine receptor motif; other site 1052684008396 Homeodomain-like domain; Region: HTH_23; cl17451 1052684008397 Integrase core domain; Region: rve; pfam00665 1052684008398 Transposase; Region: HTH_Tnp_1; cl17663 1052684008399 putative transposase OrfB; Reviewed; Region: PHA02517 1052684008400 HTH-like domain; Region: HTH_21; pfam13276 1052684008401 Integrase core domain; Region: rve; pfam00665 1052684008402 Integrase core domain; Region: rve_3; pfam13683 1052684008403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684008404 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1052684008405 DNA-binding interface [nucleotide binding]; DNA binding site 1052684008406 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052684008407 active site 1052684008408 DNA binding site [nucleotide binding] 1052684008409 Int/Topo IB signature motif; other site 1052684008410 Holin family; Region: Phage_holin_4; cl01989 1052684008411 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1052684008412 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684008413 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052684008414 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052684008415 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052684008416 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052684008417 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1052684008418 LytTr DNA-binding domain; Region: LytTR; cl04498 1052684008419 YolD-like protein; Region: YolD; pfam08863 1052684008420 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 1052684008421 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 1052684008422 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1052684008423 active site 1052684008424 DNA binding site [nucleotide binding] 1052684008425 The Oligonucleotide/oligosaccharide binding (OB)-fold domain is a DNA-binding module that is part of the catalytic core unit of ATP dependent DNA ligases; Region: OBF_DNA_ligase_family; cl08424 1052684008426 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1052684008427 putative active site [active] 1052684008428 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1052684008429 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1052684008430 Holin family; Region: Phage_holin_4; cl01989 1052684008431 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684008432 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1052684008433 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 1052684008434 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1052684008435 Phage tail protein; Region: Sipho_tail; cl17486 1052684008436 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1052684008437 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 1052684008438 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1052684008439 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1052684008440 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1052684008441 Terminase small subunit; Region: Terminase_2; pfam03592 1052684008442 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1052684008443 nudix motif; other site 1052684008444 YopX protein; Region: YopX; pfam09643 1052684008445 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1052684008446 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 1052684008447 active site 1052684008448 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684008449 non-specific DNA binding site [nucleotide binding]; other site 1052684008450 salt bridge; other site 1052684008451 sequence-specific DNA binding site [nucleotide binding]; other site 1052684008452 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 1052684008453 DNA polymerase III subunit beta; Validated; Region: PRK05643 1052684008454 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1052684008455 putative DNA binding surface [nucleotide binding]; other site 1052684008456 dimer interface [polypeptide binding]; other site 1052684008457 beta-clamp/clamp loader binding surface; other site 1052684008458 beta-clamp/translesion DNA polymerase binding surface; other site 1052684008459 primosomal protein DnaI; Reviewed; Region: PRK08939 1052684008460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684008461 Walker A motif; other site 1052684008462 ATP binding site [chemical binding]; other site 1052684008463 Walker B motif; other site 1052684008464 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681 1052684008465 ORF6C domain; Region: ORF6C; pfam10552 1052684008466 ParB-like nuclease domain; Region: ParB; smart00470 1052684008467 Domain of unknown function (DUF771); Region: DUF771; cl09962 1052684008468 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052684008469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684008470 non-specific DNA binding site [nucleotide binding]; other site 1052684008471 salt bridge; other site 1052684008472 sequence-specific DNA binding site [nucleotide binding]; other site 1052684008473 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1052684008474 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1052684008475 Int/Topo IB signature motif; other site 1052684008476 glutamine synthetase, type I; Region: GlnA; TIGR00653 1052684008477 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1052684008478 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1052684008479 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1052684008480 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052684008481 DNA binding residues [nucleotide binding] 1052684008482 putative dimer interface [polypeptide binding]; other site 1052684008483 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 1052684008484 Aluminium resistance protein; Region: Alum_res; pfam06838 1052684008485 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1052684008486 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1052684008487 HflX GTPase family; Region: HflX; cd01878 1052684008488 G1 box; other site 1052684008489 GTP/Mg2+ binding site [chemical binding]; other site 1052684008490 Switch I region; other site 1052684008491 G2 box; other site 1052684008492 G3 box; other site 1052684008493 Switch II region; other site 1052684008494 G4 box; other site 1052684008495 G5 box; other site 1052684008496 stage V sporulation protein K; Region: spore_V_K; TIGR02881 1052684008497 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684008498 Walker A motif; other site 1052684008499 ATP binding site [chemical binding]; other site 1052684008500 Walker B motif; other site 1052684008501 arginine finger; other site 1052684008502 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1052684008503 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1052684008504 putative active site [active] 1052684008505 Protein of unknown function (DUF402); Region: DUF402; cl00979 1052684008506 Transglycosylase; Region: Transgly; pfam00912 1052684008507 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052684008508 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052684008509 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684008510 Interdomain contacts; other site 1052684008511 Cytokine receptor motif; other site 1052684008512 bacterial Hfq-like; Region: Hfq; cd01716 1052684008513 hexamer interface [polypeptide binding]; other site 1052684008514 Sm1 motif; other site 1052684008515 RNA binding site [nucleotide binding]; other site 1052684008516 Sm2 motif; other site 1052684008517 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1052684008518 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1052684008519 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1052684008520 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 1052684008521 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684008522 ATP binding site [chemical binding]; other site 1052684008523 Mg2+ binding site [ion binding]; other site 1052684008524 G-X-G motif; other site 1052684008525 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1052684008526 ATP binding site [chemical binding]; other site 1052684008527 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1052684008528 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1052684008529 MutS domain I; Region: MutS_I; pfam01624 1052684008530 MutS domain II; Region: MutS_II; pfam05188 1052684008531 MutS domain III; Region: MutS_III; pfam05192 1052684008532 MutS domain V; Region: MutS_V; pfam00488 1052684008533 Walker A/P-loop; other site 1052684008534 ATP binding site [chemical binding]; other site 1052684008535 Q-loop/lid; other site 1052684008536 ABC transporter signature motif; other site 1052684008537 Walker B; other site 1052684008538 D-loop; other site 1052684008539 H-loop/switch region; other site 1052684008540 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 1052684008541 Outer spore coat protein E (CotE); Region: CotE; pfam10628 1052684008542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684008543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684008544 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684008545 dimerization interface [polypeptide binding]; other site 1052684008546 putative transporter; Provisional; Region: PRK11021 1052684008547 Predicted membrane protein [Function unknown]; Region: COG4129 1052684008548 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1052684008549 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1052684008550 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1052684008551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684008552 dimer interface [polypeptide binding]; other site 1052684008553 conserved gate region; other site 1052684008554 putative PBP binding loops; other site 1052684008555 ABC-ATPase subunit interface; other site 1052684008556 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1052684008557 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1052684008558 Walker A/P-loop; other site 1052684008559 ATP binding site [chemical binding]; other site 1052684008560 Q-loop/lid; other site 1052684008561 ABC transporter signature motif; other site 1052684008562 Walker B; other site 1052684008563 D-loop; other site 1052684008564 H-loop/switch region; other site 1052684008565 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1052684008566 NMT1-like family; Region: NMT1_2; pfam13379 1052684008567 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 1052684008568 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 1052684008569 active site 1052684008570 Zn binding site [ion binding]; other site 1052684008571 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1052684008572 active site clefts [active] 1052684008573 zinc binding site [ion binding]; other site 1052684008574 dimer interface [polypeptide binding]; other site 1052684008575 Predicted transcriptional regulators [Transcription]; Region: COG1695 1052684008576 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1052684008577 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 1052684008578 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 1052684008579 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684008580 FeS/SAM binding site; other site 1052684008581 coproporphyrinogen III oxidase; Validated; Region: PRK08208 1052684008582 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684008583 FeS/SAM binding site; other site 1052684008584 HemN C-terminal domain; Region: HemN_C; pfam06969 1052684008585 Sulfatase; Region: Sulfatase; cl17466 1052684008586 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 1052684008587 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1052684008588 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1052684008589 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1052684008590 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052684008591 putative membrane fusion protein; Region: TIGR02828 1052684008592 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1052684008593 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684008594 putative substrate translocation pore; other site 1052684008595 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1052684008596 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052684008597 E3 interaction surface; other site 1052684008598 lipoyl attachment site [posttranslational modification]; other site 1052684008599 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052684008600 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1052684008601 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1052684008602 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684008603 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1052684008604 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1052684008605 active site 1052684008606 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684008607 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684008608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684008609 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684008610 MarR family; Region: MarR; pfam01047 1052684008611 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1052684008612 MarR family; Region: MarR; pfam01047 1052684008613 DNA gyrase subunit A; Validated; Region: PRK05560 1052684008614 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1052684008615 CAP-like domain; other site 1052684008616 active site 1052684008617 primary dimer interface [polypeptide binding]; other site 1052684008618 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052684008619 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052684008620 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052684008621 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1052684008622 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1052684008623 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684008624 ATP binding site [chemical binding]; other site 1052684008625 Mg2+ binding site [ion binding]; other site 1052684008626 G-X-G motif; other site 1052684008627 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1052684008628 anchoring element; other site 1052684008629 dimer interface [polypeptide binding]; other site 1052684008630 ATP binding site [chemical binding]; other site 1052684008631 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1052684008632 active site 1052684008633 metal binding site [ion binding]; metal-binding site 1052684008634 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1052684008635 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052684008636 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1052684008637 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052684008638 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1052684008639 Walker A/P-loop; other site 1052684008640 ATP binding site [chemical binding]; other site 1052684008641 Q-loop/lid; other site 1052684008642 ABC transporter signature motif; other site 1052684008643 Walker B; other site 1052684008644 D-loop; other site 1052684008645 H-loop/switch region; other site 1052684008646 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1052684008647 active site 1052684008648 catalytic triad [active] 1052684008649 oxyanion hole [active] 1052684008650 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 1052684008651 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 1052684008652 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 1052684008653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684008654 Coenzyme A binding pocket [chemical binding]; other site 1052684008655 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1052684008656 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684008657 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1052684008658 ATP-grasp domain; Region: ATP-grasp; pfam02222 1052684008659 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684008660 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684008661 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1052684008662 Walker A/P-loop; other site 1052684008663 ATP binding site [chemical binding]; other site 1052684008664 Q-loop/lid; other site 1052684008665 ABC transporter signature motif; other site 1052684008666 Walker B; other site 1052684008667 D-loop; other site 1052684008668 H-loop/switch region; other site 1052684008669 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684008670 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684008671 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684008672 Walker A/P-loop; other site 1052684008673 ATP binding site [chemical binding]; other site 1052684008674 Q-loop/lid; other site 1052684008675 ABC transporter signature motif; other site 1052684008676 Walker B; other site 1052684008677 D-loop; other site 1052684008678 H-loop/switch region; other site 1052684008679 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1052684008680 Dynamin family; Region: Dynamin_N; pfam00350 1052684008681 G1 box; other site 1052684008682 GTP/Mg2+ binding site [chemical binding]; other site 1052684008683 G2 box; other site 1052684008684 Switch I region; other site 1052684008685 G3 box; other site 1052684008686 Switch II region; other site 1052684008687 G4 box; other site 1052684008688 G5 box; other site 1052684008689 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1052684008690 Dynamin family; Region: Dynamin_N; pfam00350 1052684008691 G1 box; other site 1052684008692 GTP/Mg2+ binding site [chemical binding]; other site 1052684008693 G2 box; other site 1052684008694 Switch I region; other site 1052684008695 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 1052684008696 G3 box; other site 1052684008697 Switch II region; other site 1052684008698 GTP/Mg2+ binding site [chemical binding]; other site 1052684008699 G4 box; other site 1052684008700 G5 box; other site 1052684008701 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1052684008702 catalytic residues [active] 1052684008703 dimer interface [polypeptide binding]; other site 1052684008704 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1052684008705 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052684008706 minor groove reading motif; other site 1052684008707 helix-hairpin-helix signature motif; other site 1052684008708 substrate binding pocket [chemical binding]; other site 1052684008709 active site 1052684008710 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1052684008711 Sporulation and spore germination; Region: Germane; pfam10646 1052684008712 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684008713 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1052684008714 AMIN domain; Region: AMIN; pfam11741 1052684008715 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052684008716 active site 1052684008717 metal binding site [ion binding]; metal-binding site 1052684008718 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684008719 AMIN domain; Region: AMIN; pfam11741 1052684008720 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1052684008721 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052684008722 active site 1052684008723 metal binding site [ion binding]; metal-binding site 1052684008724 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1052684008725 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1052684008726 substrate binding site [chemical binding]; other site 1052684008727 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1052684008728 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1052684008729 substrate binding site [chemical binding]; other site 1052684008730 ligand binding site [chemical binding]; other site 1052684008731 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1052684008732 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1052684008733 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1052684008734 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1052684008735 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1052684008736 active site 1052684008737 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1052684008738 active site 1052684008739 catalytic site [active] 1052684008740 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1052684008741 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1052684008742 [4Fe-4S] binding site [ion binding]; other site 1052684008743 molybdopterin cofactor binding site; other site 1052684008744 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1052684008745 molybdopterin cofactor binding site; other site 1052684008746 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1052684008747 4Fe-4S binding domain; Region: Fer4; pfam00037 1052684008748 [FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512 1052684008749 4Fe-4S binding domain; Region: Fer4; pfam00037 1052684008750 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 1052684008751 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 1052684008752 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1052684008753 4Fe-4S binding domain; Region: Fer4; pfam00037 1052684008754 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1052684008755 Aspartase; Region: Aspartase; cd01357 1052684008756 active sites [active] 1052684008757 tetramer interface [polypeptide binding]; other site 1052684008758 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 1052684008759 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 1052684008760 G1 box; other site 1052684008761 GTP/Mg2+ binding site [chemical binding]; other site 1052684008762 Switch I region; other site 1052684008763 G2 box; other site 1052684008764 Switch II region; other site 1052684008765 G3 box; other site 1052684008766 G4 box; other site 1052684008767 G5 box; other site 1052684008768 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 1052684008769 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684008770 FeS/SAM binding site; other site 1052684008771 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1052684008772 biotin synthase; Provisional; Region: PRK07094 1052684008773 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684008774 FeS/SAM binding site; other site 1052684008775 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1052684008776 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1052684008777 Alkaline phosphatase homologues; Region: alkPPc; smart00098 1052684008778 active site 1052684008779 dimer interface [polypeptide binding]; other site 1052684008780 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684008781 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684008782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684008783 dimerization interface [polypeptide binding]; other site 1052684008784 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684008785 non-specific DNA binding site [nucleotide binding]; other site 1052684008786 salt bridge; other site 1052684008787 sequence-specific DNA binding site [nucleotide binding]; other site 1052684008788 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1052684008789 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 1052684008790 putative active site [active] 1052684008791 catalytic triad [active] 1052684008792 putative dimer interface [polypeptide binding]; other site 1052684008793 transaminase; Reviewed; Region: PRK08068 1052684008794 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684008795 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684008796 homodimer interface [polypeptide binding]; other site 1052684008797 catalytic residue [active] 1052684008798 gamma-glutamyl kinase; Provisional; Region: PRK05429 1052684008799 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1052684008800 nucleotide binding site [chemical binding]; other site 1052684008801 homotetrameric interface [polypeptide binding]; other site 1052684008802 putative phosphate binding site [ion binding]; other site 1052684008803 putative allosteric binding site; other site 1052684008804 PUA domain; Region: PUA; pfam01472 1052684008805 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1052684008806 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1052684008807 putative catalytic cysteine [active] 1052684008808 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1052684008809 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1052684008810 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 1052684008811 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 1052684008812 dimer interface [polypeptide binding]; other site 1052684008813 active site 1052684008814 catalytic residue [active] 1052684008815 metal binding site [ion binding]; metal-binding site 1052684008816 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1052684008817 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684008818 active site 1052684008819 motif I; other site 1052684008820 motif II; other site 1052684008821 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1052684008822 intersubunit interface [polypeptide binding]; other site 1052684008823 active site 1052684008824 Zn2+ binding site [ion binding]; other site 1052684008825 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1052684008826 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1052684008827 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684008828 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684008829 DNA binding residues [nucleotide binding] 1052684008830 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1052684008831 Helix-turn-helix domain; Region: HTH_36; pfam13730 1052684008832 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1052684008833 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1052684008834 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1052684008835 putative dimer interface [polypeptide binding]; other site 1052684008836 putative anticodon binding site; other site 1052684008837 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1052684008838 homodimer interface [polypeptide binding]; other site 1052684008839 motif 1; other site 1052684008840 motif 2; other site 1052684008841 active site 1052684008842 motif 3; other site 1052684008843 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1052684008844 propionate/acetate kinase; Provisional; Region: PRK12379 1052684008845 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1052684008846 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1052684008847 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1052684008848 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1052684008849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684008850 Walker A motif; other site 1052684008851 ATP binding site [chemical binding]; other site 1052684008852 Walker B motif; other site 1052684008853 arginine finger; other site 1052684008854 Peptidase family M41; Region: Peptidase_M41; pfam01434 1052684008855 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1052684008856 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 1052684008857 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1052684008858 active site 1052684008859 putative substrate binding pocket [chemical binding]; other site 1052684008860 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1052684008861 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1052684008862 CoA binding domain; Region: CoA_binding; smart00881 1052684008863 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 1052684008864 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1052684008865 active site 1052684008866 catalytic site [active] 1052684008867 substrate binding site [chemical binding]; other site 1052684008868 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1052684008869 ATP binding site [chemical binding]; other site 1052684008870 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052684008871 putative Mg++ binding site [ion binding]; other site 1052684008872 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1052684008873 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052684008874 binding surface 1052684008875 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052684008876 TPR motif; other site 1052684008877 TPR repeat; Region: TPR_11; pfam13414 1052684008878 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1052684008879 tetramerization interface [polypeptide binding]; other site 1052684008880 active site 1052684008881 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1052684008882 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1052684008883 active site 1052684008884 ATP-binding site [chemical binding]; other site 1052684008885 pantoate-binding site; other site 1052684008886 HXXH motif; other site 1052684008887 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1052684008888 oligomerization interface [polypeptide binding]; other site 1052684008889 active site 1052684008890 metal binding site [ion binding]; metal-binding site 1052684008891 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1052684008892 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1052684008893 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1052684008894 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1052684008895 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1052684008896 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1052684008897 active site 1052684008898 NTP binding site [chemical binding]; other site 1052684008899 metal binding triad [ion binding]; metal-binding site 1052684008900 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1052684008901 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1052684008902 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 1052684008903 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 1052684008904 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 1052684008905 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1052684008906 active site 1052684008907 dimer interfaces [polypeptide binding]; other site 1052684008908 catalytic residues [active] 1052684008909 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1052684008910 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1052684008911 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1052684008912 TPR repeat; Region: TPR_11; pfam13414 1052684008913 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052684008914 binding surface 1052684008915 TPR motif; other site 1052684008916 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1052684008917 TPR motif; other site 1052684008918 binding surface 1052684008919 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 1052684008920 homodimer interface [polypeptide binding]; other site 1052684008921 metal binding site [ion binding]; metal-binding site 1052684008922 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052684008923 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052684008924 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052684008925 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052684008926 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 1052684008927 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684008928 Coenzyme A binding pocket [chemical binding]; other site 1052684008929 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 1052684008930 IDEAL domain; Region: IDEAL; cl07452 1052684008931 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1052684008932 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1052684008933 trimer interface [polypeptide binding]; other site 1052684008934 putative metal binding site [ion binding]; other site 1052684008935 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1052684008936 catalytic core [active] 1052684008937 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1052684008938 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684008939 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684008940 DNA binding residues [nucleotide binding] 1052684008941 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052684008942 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684008943 S-adenosylmethionine binding site [chemical binding]; other site 1052684008944 prephenate dehydrogenase; Validated; Region: PRK08507 1052684008945 prephenate dehydrogenase; Validated; Region: PRK06545 1052684008946 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1052684008947 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 1052684008948 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684008949 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684008950 homodimer interface [polypeptide binding]; other site 1052684008951 catalytic residue [active] 1052684008952 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1052684008953 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1052684008954 substrate binding site [chemical binding]; other site 1052684008955 active site 1052684008956 catalytic residues [active] 1052684008957 heterodimer interface [polypeptide binding]; other site 1052684008958 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1052684008959 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1052684008960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684008961 catalytic residue [active] 1052684008962 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1052684008963 active site 1052684008964 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1052684008965 active site 1052684008966 ribulose/triose binding site [chemical binding]; other site 1052684008967 phosphate binding site [ion binding]; other site 1052684008968 substrate (anthranilate) binding pocket [chemical binding]; other site 1052684008969 product (indole) binding pocket [chemical binding]; other site 1052684008970 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1052684008971 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1052684008972 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1052684008973 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 1052684008974 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1052684008975 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1052684008976 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 1052684008977 homotrimer interaction site [polypeptide binding]; other site 1052684008978 active site 1052684008979 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1052684008980 active site 1052684008981 dimer interface [polypeptide binding]; other site 1052684008982 metal binding site [ion binding]; metal-binding site 1052684008983 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1052684008984 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1052684008985 Tetramer interface [polypeptide binding]; other site 1052684008986 active site 1052684008987 FMN-binding site [chemical binding]; other site 1052684008988 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1052684008989 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1052684008990 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684008991 S-adenosylmethionine binding site [chemical binding]; other site 1052684008992 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1052684008993 active site 1052684008994 multimer interface [polypeptide binding]; other site 1052684008995 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1052684008996 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1052684008997 substrate binding pocket [chemical binding]; other site 1052684008998 chain length determination region; other site 1052684008999 substrate-Mg2+ binding site; other site 1052684009000 catalytic residues [active] 1052684009001 aspartate-rich region 1; other site 1052684009002 active site lid residues [active] 1052684009003 aspartate-rich region 2; other site 1052684009004 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 1052684009005 aromatic acid decarboxylase; Validated; Region: PRK05920 1052684009006 Flavoprotein; Region: Flavoprotein; pfam02441 1052684009007 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1052684009008 UbiA prenyltransferase family; Region: UbiA; pfam01040 1052684009009 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1052684009010 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684009011 S-adenosylmethionine binding site [chemical binding]; other site 1052684009012 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 1052684009013 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 1052684009014 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1052684009015 IHF - DNA interface [nucleotide binding]; other site 1052684009016 IHF dimer interface [polypeptide binding]; other site 1052684009017 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1052684009018 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1052684009019 TM-ABC transporter signature motif; other site 1052684009020 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1052684009021 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1052684009022 Walker A/P-loop; other site 1052684009023 ATP binding site [chemical binding]; other site 1052684009024 Q-loop/lid; other site 1052684009025 ABC transporter signature motif; other site 1052684009026 Walker B; other site 1052684009027 D-loop; other site 1052684009028 H-loop/switch region; other site 1052684009029 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1052684009030 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 1052684009031 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1052684009032 putative ligand binding site [chemical binding]; other site 1052684009033 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 1052684009034 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1052684009035 G1 box; other site 1052684009036 GTP/Mg2+ binding site [chemical binding]; other site 1052684009037 G2 box; other site 1052684009038 Switch I region; other site 1052684009039 G3 box; other site 1052684009040 Switch II region; other site 1052684009041 G4 box; other site 1052684009042 G5 box; other site 1052684009043 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1052684009044 catalytic loop [active] 1052684009045 iron binding site [ion binding]; other site 1052684009046 putative transposase OrfB; Reviewed; Region: PHA02517 1052684009047 HTH-like domain; Region: HTH_21; pfam13276 1052684009048 Integrase core domain; Region: rve; pfam00665 1052684009049 Integrase core domain; Region: rve_3; pfam13683 1052684009050 Transposase; Region: HTH_Tnp_1; cl17663 1052684009051 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1052684009052 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1052684009053 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1052684009054 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1052684009055 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1052684009056 GTP-binding protein Der; Reviewed; Region: PRK00093 1052684009057 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1052684009058 G1 box; other site 1052684009059 GTP/Mg2+ binding site [chemical binding]; other site 1052684009060 Switch I region; other site 1052684009061 G2 box; other site 1052684009062 Switch II region; other site 1052684009063 G3 box; other site 1052684009064 G4 box; other site 1052684009065 G5 box; other site 1052684009066 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1052684009067 G1 box; other site 1052684009068 GTP/Mg2+ binding site [chemical binding]; other site 1052684009069 Switch I region; other site 1052684009070 G2 box; other site 1052684009071 G3 box; other site 1052684009072 Switch II region; other site 1052684009073 G4 box; other site 1052684009074 G5 box; other site 1052684009075 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1052684009076 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1052684009077 RNA binding site [nucleotide binding]; other site 1052684009078 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1052684009079 RNA binding site [nucleotide binding]; other site 1052684009080 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1052684009081 RNA binding site [nucleotide binding]; other site 1052684009082 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1052684009083 RNA binding site [nucleotide binding]; other site 1052684009084 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1052684009085 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1052684009086 putative acyl-acceptor binding pocket; other site 1052684009087 cytidylate kinase; Provisional; Region: cmk; PRK00023 1052684009088 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1052684009089 CMP-binding site; other site 1052684009090 The sites determining sugar specificity; other site 1052684009091 Flagellar protein YcgR; Region: YcgR_2; pfam12945 1052684009092 PilZ domain; Region: PilZ; pfam07238 1052684009093 germination protein YpeB; Region: spore_YpeB; TIGR02889 1052684009094 Protease prsW family; Region: PrsW-protease; pfam13367 1052684009095 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 1052684009096 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1052684009097 NodB motif; other site 1052684009098 active site 1052684009099 catalytic site [active] 1052684009100 metal binding site [ion binding]; metal-binding site 1052684009101 CAAX protease self-immunity; Region: Abi; pfam02517 1052684009102 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1052684009103 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1052684009104 ligand binding site [chemical binding]; other site 1052684009105 NAD binding site [chemical binding]; other site 1052684009106 dimerization interface [polypeptide binding]; other site 1052684009107 catalytic site [active] 1052684009108 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1052684009109 putative L-serine binding site [chemical binding]; other site 1052684009110 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684009111 dimerization interface [polypeptide binding]; other site 1052684009112 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1052684009113 PAS domain; Region: PAS; smart00091 1052684009114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684009115 dimer interface [polypeptide binding]; other site 1052684009116 phosphorylation site [posttranslational modification] 1052684009117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684009118 ATP binding site [chemical binding]; other site 1052684009119 Mg2+ binding site [ion binding]; other site 1052684009120 G-X-G motif; other site 1052684009121 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684009122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684009123 active site 1052684009124 phosphorylation site [posttranslational modification] 1052684009125 intermolecular recognition site; other site 1052684009126 dimerization interface [polypeptide binding]; other site 1052684009127 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684009128 DNA binding site [nucleotide binding] 1052684009129 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1052684009130 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052684009131 RNA binding surface [nucleotide binding]; other site 1052684009132 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1052684009133 active site 1052684009134 Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700 1052684009135 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 1052684009136 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1052684009137 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1052684009138 transglutaminase; Provisional; Region: tgl; PRK03187 1052684009139 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 1052684009140 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 1052684009141 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1052684009142 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1052684009143 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1052684009144 homopentamer interface [polypeptide binding]; other site 1052684009145 active site 1052684009146 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1052684009147 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1052684009148 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1052684009149 Lumazine binding domain; Region: Lum_binding; pfam00677 1052684009150 Lumazine binding domain; Region: Lum_binding; pfam00677 1052684009151 IDEAL domain; Region: IDEAL; cl07452 1052684009152 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 1052684009153 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1052684009154 dimer interface [polypeptide binding]; other site 1052684009155 PYR/PP interface [polypeptide binding]; other site 1052684009156 TPP binding site [chemical binding]; other site 1052684009157 substrate binding site [chemical binding]; other site 1052684009158 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 1052684009159 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1052684009160 TPP-binding site [chemical binding]; other site 1052684009161 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 1052684009162 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 1052684009163 4Fe-4S binding domain; Region: Fer4; pfam00037 1052684009164 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1052684009165 active site 1052684009166 diaminopimelate decarboxylase; Region: lysA; TIGR01048 1052684009167 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1052684009168 active site 1052684009169 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052684009170 substrate binding site [chemical binding]; other site 1052684009171 catalytic residues [active] 1052684009172 dimer interface [polypeptide binding]; other site 1052684009173 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052684009174 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 1052684009175 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 1052684009176 sporulation sigma factor SigF; Validated; Region: PRK05572 1052684009177 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684009178 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052684009179 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684009180 DNA binding residues [nucleotide binding] 1052684009181 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 1052684009182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684009183 ATP binding site [chemical binding]; other site 1052684009184 Mg2+ binding site [ion binding]; other site 1052684009185 G-X-G motif; other site 1052684009186 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1052684009187 anti sigma factor interaction site; other site 1052684009188 regulatory phosphorylation site [posttranslational modification]; other site 1052684009189 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1052684009190 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1052684009191 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1052684009192 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1052684009193 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1052684009194 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1052684009195 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1052684009196 active site 1052684009197 Int/Topo IB signature motif; other site 1052684009198 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 1052684009199 ferric uptake regulator; Provisional; Region: fur; PRK09462 1052684009200 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052684009201 metal binding site 2 [ion binding]; metal-binding site 1052684009202 putative DNA binding helix; other site 1052684009203 metal binding site 1 [ion binding]; metal-binding site 1052684009204 dimer interface [polypeptide binding]; other site 1052684009205 structural Zn2+ binding site [ion binding]; other site 1052684009206 Integral membrane protein DUF95; Region: DUF95; cl00572 1052684009207 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 1052684009208 PHP-associated; Region: PHP_C; pfam13263 1052684009209 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 1052684009210 iron binding site [ion binding]; other site 1052684009211 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1052684009212 dimer interface [polypeptide binding]; other site 1052684009213 ADP-ribose binding site [chemical binding]; other site 1052684009214 active site 1052684009215 nudix motif; other site 1052684009216 metal binding site [ion binding]; metal-binding site 1052684009217 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 1052684009218 peptidase T-like protein; Region: PepT-like; TIGR01883 1052684009219 metal binding site [ion binding]; metal-binding site 1052684009220 putative dimer interface [polypeptide binding]; other site 1052684009221 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1052684009222 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1052684009223 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1052684009224 E3 interaction surface; other site 1052684009225 lipoyl attachment site [posttranslational modification]; other site 1052684009226 e3 binding domain; Region: E3_binding; pfam02817 1052684009227 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1052684009228 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1052684009229 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1052684009230 alpha subunit interface [polypeptide binding]; other site 1052684009231 TPP binding site [chemical binding]; other site 1052684009232 heterodimer interface [polypeptide binding]; other site 1052684009233 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052684009234 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1052684009235 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1052684009236 tetramer interface [polypeptide binding]; other site 1052684009237 TPP-binding site [chemical binding]; other site 1052684009238 heterodimer interface [polypeptide binding]; other site 1052684009239 phosphorylation loop region [posttranslational modification] 1052684009240 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 1052684009241 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1052684009242 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684009243 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052684009244 thymidine kinase; Provisional; Region: PRK04296 1052684009245 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 1052684009246 SpoOM protein; Region: Spo0M; pfam07070 1052684009247 putative transposase OrfB; Reviewed; Region: PHA02517 1052684009248 HTH-like domain; Region: HTH_21; pfam13276 1052684009249 Integrase core domain; Region: rve; pfam00665 1052684009250 Integrase core domain; Region: rve_3; pfam13683 1052684009251 Transposase; Region: HTH_Tnp_1; cl17663 1052684009252 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1052684009253 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684009254 dimerization interface [polypeptide binding]; other site 1052684009255 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684009256 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684009257 dimer interface [polypeptide binding]; other site 1052684009258 putative CheW interface [polypeptide binding]; other site 1052684009259 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052684009260 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684009261 S-adenosylmethionine binding site [chemical binding]; other site 1052684009262 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1052684009263 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 1052684009264 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684009265 active site 1052684009266 phosphorylation site [posttranslational modification] 1052684009267 intermolecular recognition site; other site 1052684009268 dimerization interface [polypeptide binding]; other site 1052684009269 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 1052684009270 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1052684009271 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1052684009272 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1052684009273 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1052684009274 Walker A/P-loop; other site 1052684009275 ATP binding site [chemical binding]; other site 1052684009276 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1052684009277 ABC transporter signature motif; other site 1052684009278 Walker B; other site 1052684009279 D-loop; other site 1052684009280 H-loop/switch region; other site 1052684009281 arginine repressor; Provisional; Region: PRK04280 1052684009282 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1052684009283 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1052684009284 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1052684009285 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052684009286 RNA binding surface [nucleotide binding]; other site 1052684009287 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1052684009288 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1052684009289 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1052684009290 TPP-binding site; other site 1052684009291 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1052684009292 PYR/PP interface [polypeptide binding]; other site 1052684009293 dimer interface [polypeptide binding]; other site 1052684009294 TPP binding site [chemical binding]; other site 1052684009295 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052684009296 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1052684009297 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1052684009298 substrate binding pocket [chemical binding]; other site 1052684009299 chain length determination region; other site 1052684009300 substrate-Mg2+ binding site; other site 1052684009301 catalytic residues [active] 1052684009302 aspartate-rich region 1; other site 1052684009303 active site lid residues [active] 1052684009304 aspartate-rich region 2; other site 1052684009305 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1052684009306 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1052684009307 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1052684009308 generic binding surface II; other site 1052684009309 generic binding surface I; other site 1052684009310 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 1052684009311 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1052684009312 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1052684009313 homodimer interface [polypeptide binding]; other site 1052684009314 NADP binding site [chemical binding]; other site 1052684009315 substrate binding site [chemical binding]; other site 1052684009316 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1052684009317 putative RNA binding site [nucleotide binding]; other site 1052684009318 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 1052684009319 Asp23 family; Region: Asp23; cl00574 1052684009320 Asp23 family; Region: Asp23; pfam03780 1052684009321 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1052684009322 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052684009323 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1052684009324 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1052684009325 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1052684009326 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1052684009327 carboxyltransferase (CT) interaction site; other site 1052684009328 biotinylation site [posttranslational modification]; other site 1052684009329 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 1052684009330 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 1052684009331 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 1052684009332 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 1052684009333 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 1052684009334 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 1052684009335 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 1052684009336 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 1052684009337 NTPase; Region: NTPase_1; cl17478 1052684009338 aspartate kinase; Reviewed; Region: PRK06635 1052684009339 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 1052684009340 putative catalytic residues [active] 1052684009341 putative nucleotide binding site [chemical binding]; other site 1052684009342 putative aspartate binding site [chemical binding]; other site 1052684009343 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1052684009344 putative allosteric regulatory site; other site 1052684009345 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1052684009346 elongation factor P; Validated; Region: PRK00529 1052684009347 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1052684009348 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1052684009349 RNA binding site [nucleotide binding]; other site 1052684009350 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1052684009351 RNA binding site [nucleotide binding]; other site 1052684009352 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1052684009353 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1052684009354 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1052684009355 active site 1052684009356 Conserved membrane protein YqhR; Region: YqhR; pfam11085 1052684009357 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052684009358 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052684009359 siderophore binding site; other site 1052684009360 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 1052684009361 Oxygen tolerance; Region: BatD; pfam13584 1052684009362 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 1052684009363 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 1052684009364 active site 1052684009365 nucleophile elbow; other site 1052684009366 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684009367 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1052684009368 manganese transport transcriptional regulator; Provisional; Region: PRK03902 1052684009369 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1052684009370 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1052684009371 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1052684009372 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684009373 FeS/SAM binding site; other site 1052684009374 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1052684009375 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1052684009376 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1052684009377 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1052684009378 active site 1052684009379 HIGH motif; other site 1052684009380 KMSKS motif; other site 1052684009381 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1052684009382 tRNA binding surface [nucleotide binding]; other site 1052684009383 anticodon binding site; other site 1052684009384 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1052684009385 dimer interface [polypeptide binding]; other site 1052684009386 putative tRNA-binding site [nucleotide binding]; other site 1052684009387 Haemolytic domain; Region: Haemolytic; pfam01809 1052684009388 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052684009389 metal binding site 2 [ion binding]; metal-binding site 1052684009390 putative DNA binding helix; other site 1052684009391 metal binding site 1 [ion binding]; metal-binding site 1052684009392 dimer interface [polypeptide binding]; other site 1052684009393 structural Zn2+ binding site [ion binding]; other site 1052684009394 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684009395 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1052684009396 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684009397 FeS/SAM binding site; other site 1052684009398 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1052684009399 Pyruvate formate lyase 1; Region: PFL1; cd01678 1052684009400 coenzyme A binding site [chemical binding]; other site 1052684009401 active site 1052684009402 catalytic residues [active] 1052684009403 glycine loop; other site 1052684009404 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1052684009405 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1052684009406 putative catalytic cysteine [active] 1052684009407 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1052684009408 putative active site [active] 1052684009409 metal binding site [ion binding]; metal-binding site 1052684009410 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1052684009411 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1052684009412 ligand binding site [chemical binding]; other site 1052684009413 flexible hinge region; other site 1052684009414 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1052684009415 non-specific DNA interactions [nucleotide binding]; other site 1052684009416 DNA binding site [nucleotide binding] 1052684009417 sequence specific DNA binding site [nucleotide binding]; other site 1052684009418 putative cAMP binding site [chemical binding]; other site 1052684009419 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1052684009420 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1052684009421 putative active site [active] 1052684009422 metal binding site [ion binding]; metal-binding site 1052684009423 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684009424 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052684009425 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1052684009426 conserved cys residue [active] 1052684009427 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1052684009428 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1052684009429 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052684009430 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684009431 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052684009432 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1052684009433 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684009434 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684009435 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684009436 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684009437 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1052684009438 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1052684009439 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052684009440 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684009441 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1052684009442 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1052684009443 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052684009444 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1052684009445 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1052684009446 SelR domain; Region: SelR; pfam01641 1052684009447 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 1052684009448 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 1052684009449 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052684009450 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052684009451 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052684009452 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052684009453 EamA-like transporter family; Region: EamA; pfam00892 1052684009454 Transglycosylase; Region: Transgly; pfam00912 1052684009455 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052684009456 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1052684009457 Y-family of DNA polymerases; Region: PolY; cl12025 1052684009458 active site 1052684009459 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1052684009460 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684009461 salt bridge; other site 1052684009462 non-specific DNA binding site [nucleotide binding]; other site 1052684009463 sequence-specific DNA binding site [nucleotide binding]; other site 1052684009464 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052684009465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684009466 putative substrate translocation pore; other site 1052684009467 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1052684009468 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052684009469 DNA polymerase IV; Reviewed; Region: PRK03103 1052684009470 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1052684009471 active site 1052684009472 DNA binding site [nucleotide binding] 1052684009473 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 1052684009474 active site 1052684009475 catalytic residues [active] 1052684009476 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052684009477 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1052684009478 active site 1052684009479 arsenical pump membrane protein; Provisional; Region: PRK15445 1052684009480 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1052684009481 transmembrane helices; other site 1052684009482 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684009483 dimerization interface [polypeptide binding]; other site 1052684009484 putative DNA binding site [nucleotide binding]; other site 1052684009485 putative Zn2+ binding site [ion binding]; other site 1052684009486 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684009487 MarR family; Region: MarR_2; pfam12802 1052684009488 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052684009489 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684009490 S-adenosylmethionine binding site [chemical binding]; other site 1052684009491 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1052684009492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684009493 Coenzyme A binding pocket [chemical binding]; other site 1052684009494 DGQHR domain; Region: DGQHR; TIGR03187 1052684009495 DNA-sulfur modification-associated; Region: DndB; cl17621 1052684009496 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684009497 non-specific DNA binding site [nucleotide binding]; other site 1052684009498 salt bridge; other site 1052684009499 sequence-specific DNA binding site [nucleotide binding]; other site 1052684009500 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1052684009501 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052684009502 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1052684009503 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1052684009504 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1052684009505 DNA binding residues [nucleotide binding] 1052684009506 putative dimer interface [polypeptide binding]; other site 1052684009507 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 1052684009508 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1052684009509 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052684009510 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1052684009511 DNA binding site [nucleotide binding] 1052684009512 Int/Topo IB signature motif; other site 1052684009513 active site 1052684009514 catalytic residues [active] 1052684009515 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1052684009516 Helix-turn-helix domain; Region: HTH_17; pfam12728 1052684009517 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 1052684009518 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1052684009519 active site 1052684009520 catalytic residues [active] 1052684009521 DNA binding site [nucleotide binding] 1052684009522 Int/Topo IB signature motif; other site 1052684009523 Y-family of DNA polymerases; Region: PolY; cl12025 1052684009524 DNA binding site [nucleotide binding] 1052684009525 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1052684009526 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684009527 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684009528 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684009529 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684009530 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1052684009531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684009532 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 1052684009533 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1052684009534 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1052684009535 generic binding surface II; other site 1052684009536 ssDNA binding site; other site 1052684009537 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052684009538 ATP binding site [chemical binding]; other site 1052684009539 putative Mg++ binding site [ion binding]; other site 1052684009540 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684009541 nucleotide binding region [chemical binding]; other site 1052684009542 ATP-binding site [chemical binding]; other site 1052684009543 EDD domain protein, DegV family; Region: DegV; TIGR00762 1052684009544 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1052684009545 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1052684009546 DAK2 domain; Region: Dak2; pfam02734 1052684009547 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1052684009548 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1052684009549 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1052684009550 substrate binding site [chemical binding]; other site 1052684009551 hexamer interface [polypeptide binding]; other site 1052684009552 metal binding site [ion binding]; metal-binding site 1052684009553 GTPase RsgA; Reviewed; Region: PRK00098 1052684009554 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1052684009555 RNA binding site [nucleotide binding]; other site 1052684009556 homodimer interface [polypeptide binding]; other site 1052684009557 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1052684009558 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1052684009559 GTP/Mg2+ binding site [chemical binding]; other site 1052684009560 G4 box; other site 1052684009561 G5 box; other site 1052684009562 G1 box; other site 1052684009563 Switch I region; other site 1052684009564 G2 box; other site 1052684009565 G3 box; other site 1052684009566 Switch II region; other site 1052684009567 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1052684009568 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1052684009569 active site 1052684009570 ATP binding site [chemical binding]; other site 1052684009571 substrate binding site [chemical binding]; other site 1052684009572 activation loop (A-loop); other site 1052684009573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1052684009574 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052684009575 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052684009576 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1052684009577 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1052684009578 active site 1052684009579 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1052684009580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684009581 FeS/SAM binding site; other site 1052684009582 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1052684009583 NusB family; Region: NusB; pfam01029 1052684009584 putative RNA binding site [nucleotide binding]; other site 1052684009585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684009586 S-adenosylmethionine binding site [chemical binding]; other site 1052684009587 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1052684009588 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1052684009589 putative active site [active] 1052684009590 substrate binding site [chemical binding]; other site 1052684009591 putative cosubstrate binding site; other site 1052684009592 catalytic site [active] 1052684009593 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1052684009594 substrate binding site [chemical binding]; other site 1052684009595 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1052684009596 active site 1052684009597 catalytic residues [active] 1052684009598 metal binding site [ion binding]; metal-binding site 1052684009599 primosomal protein N' Region: priA; TIGR00595 1052684009600 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052684009601 ATP binding site [chemical binding]; other site 1052684009602 putative Mg++ binding site [ion binding]; other site 1052684009603 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684009604 nucleotide binding region [chemical binding]; other site 1052684009605 ATP-binding site [chemical binding]; other site 1052684009606 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1052684009607 Flavoprotein; Region: Flavoprotein; pfam02441 1052684009608 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1052684009609 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1052684009610 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1052684009611 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1052684009612 catalytic site [active] 1052684009613 G-X2-G-X-G-K; other site 1052684009614 hypothetical protein; Provisional; Region: PRK04323 1052684009615 hypothetical protein; Provisional; Region: PRK11820 1052684009616 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1052684009617 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1052684009618 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 1052684009619 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 1052684009620 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1052684009621 FAD binding site [chemical binding]; other site 1052684009622 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1052684009623 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1052684009624 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1052684009625 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1052684009626 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1052684009627 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052684009628 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1052684009629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684009630 motif II; other site 1052684009631 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1052684009632 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 1052684009633 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1052684009634 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1052684009635 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1052684009636 active site 1052684009637 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1052684009638 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684009639 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684009640 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1052684009641 putative dimerization interface [polypeptide binding]; other site 1052684009642 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 1052684009643 Protein of unknown function (DUF964); Region: DUF964; pfam06133 1052684009644 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1052684009645 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 1052684009646 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1052684009647 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052684009648 ATP binding site [chemical binding]; other site 1052684009649 putative Mg++ binding site [ion binding]; other site 1052684009650 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684009651 nucleotide binding region [chemical binding]; other site 1052684009652 ATP-binding site [chemical binding]; other site 1052684009653 FOG: CBS domain [General function prediction only]; Region: COG0517 1052684009654 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 1052684009655 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052684009656 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 1052684009657 metal binding site [ion binding]; metal-binding site 1052684009658 dimer interface [polypeptide binding]; other site 1052684009659 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1052684009660 Asp23 family; Region: Asp23; pfam03780 1052684009661 calcium/proton exchanger (cax); Region: cax; TIGR00378 1052684009662 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1052684009663 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1052684009664 hypothetical protein; Provisional; Region: PRK13666 1052684009665 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052684009666 regulatory protein interface [polypeptide binding]; other site 1052684009667 regulatory phosphorylation site [posttranslational modification]; other site 1052684009668 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1052684009669 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1052684009670 GAF domain; Region: GAF_3; pfam13492 1052684009671 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1052684009672 GAF domain; Region: GAF; pfam01590 1052684009673 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052684009674 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052684009675 metal binding site [ion binding]; metal-binding site 1052684009676 active site 1052684009677 I-site; other site 1052684009678 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1052684009679 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1052684009680 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052684009681 RNA binding surface [nucleotide binding]; other site 1052684009682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684009683 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684009684 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684009685 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1052684009686 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1052684009687 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1052684009688 active site 1052684009689 HIGH motif; other site 1052684009690 dimer interface [polypeptide binding]; other site 1052684009691 KMSKS motif; other site 1052684009692 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052684009693 RNA binding surface [nucleotide binding]; other site 1052684009694 Transglycosylase; Region: Transgly; pfam00912 1052684009695 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1052684009696 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1052684009697 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684009698 Interdomain contacts; other site 1052684009699 Cytokine receptor motif; other site 1052684009700 acetyl-CoA synthetase; Provisional; Region: PRK04319 1052684009701 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 1052684009702 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052684009703 acyl-activating enzyme (AAE) consensus motif; other site 1052684009704 AMP binding site [chemical binding]; other site 1052684009705 active site 1052684009706 CoA binding site [chemical binding]; other site 1052684009707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684009708 Coenzyme A binding pocket [chemical binding]; other site 1052684009709 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1052684009710 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1052684009711 catabolite control protein A; Region: ccpA; TIGR01481 1052684009712 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684009713 DNA binding site [nucleotide binding] 1052684009714 domain linker motif; other site 1052684009715 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1052684009716 dimerization interface [polypeptide binding]; other site 1052684009717 effector binding site; other site 1052684009718 bacillithiol system protein YtxJ; Region: B_thiol_YtxJ; TIGR04019 1052684009719 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1052684009720 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1052684009721 proposed catalytic triad [active] 1052684009722 conserved cys residue [active] 1052684009723 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1052684009724 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1052684009725 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1052684009726 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1052684009727 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1052684009728 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684009729 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052684009730 active site turn [active] 1052684009731 phosphorylation site [posttranslational modification] 1052684009732 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052684009733 HPr interaction site; other site 1052684009734 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052684009735 active site 1052684009736 phosphorylation site [posttranslational modification] 1052684009737 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1052684009738 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1052684009739 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1052684009740 hinge; other site 1052684009741 active site 1052684009742 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1052684009743 active site residue [active] 1052684009744 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1052684009745 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1052684009746 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1052684009747 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 1052684009748 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 1052684009749 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684009750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684009751 putative substrate translocation pore; other site 1052684009752 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 1052684009753 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1052684009754 homodimer interface [polypeptide binding]; other site 1052684009755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684009756 catalytic residue [active] 1052684009757 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1052684009758 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 1052684009759 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052684009760 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 1052684009761 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052684009762 Small subunit of nitrite reductase (NirD) family, Rieske domain; composed of proteins similar to the Bacillus subtilis small subunit of assimilatory nitrite reductase containing a Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain...; Region: Rieske_NirD_small_Bacillus; cd03530 1052684009763 [2Fe-2S] cluster binding site [ion binding]; other site 1052684009764 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 1052684009765 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684009766 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1052684009767 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1052684009768 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052684009769 ANTAR domain; Region: ANTAR; pfam03861 1052684009770 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 1052684009771 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1052684009772 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1052684009773 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1052684009774 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1052684009775 [4Fe-4S] binding site [ion binding]; other site 1052684009776 molybdopterin cofactor binding site; other site 1052684009777 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 1052684009778 molybdopterin cofactor binding site; other site 1052684009779 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1052684009780 Domain of unknown function (DUF4313); Region: DUF4313; pfam14190 1052684009781 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684009782 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1052684009783 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1052684009784 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684009785 putative substrate translocation pore; other site 1052684009786 malate dehydrogenase; Provisional; Region: PRK13529 1052684009787 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052684009788 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1052684009789 NAD(P) binding site [chemical binding]; other site 1052684009790 Membrane transport protein; Region: Mem_trans; cl09117 1052684009791 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684009792 dimerization interface [polypeptide binding]; other site 1052684009793 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684009794 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684009795 dimer interface [polypeptide binding]; other site 1052684009796 putative CheW interface [polypeptide binding]; other site 1052684009797 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1052684009798 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1052684009799 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1052684009800 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1052684009801 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1052684009802 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684009803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684009804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1052684009805 ABC-ATPase subunit interface; other site 1052684009806 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684009807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684009808 dimer interface [polypeptide binding]; other site 1052684009809 conserved gate region; other site 1052684009810 putative PBP binding loops; other site 1052684009811 ABC-ATPase subunit interface; other site 1052684009812 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684009813 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684009814 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684009815 active site 1052684009816 phosphorylation site [posttranslational modification] 1052684009817 intermolecular recognition site; other site 1052684009818 dimerization interface [polypeptide binding]; other site 1052684009819 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684009820 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684009821 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684009822 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684009823 dimerization interface [polypeptide binding]; other site 1052684009824 Histidine kinase; Region: His_kinase; pfam06580 1052684009825 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684009826 ATP binding site [chemical binding]; other site 1052684009827 Mg2+ binding site [ion binding]; other site 1052684009828 G-X-G motif; other site 1052684009829 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1052684009830 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1052684009831 ligand binding site [chemical binding]; other site 1052684009832 active site 1052684009833 UGI interface [polypeptide binding]; other site 1052684009834 catalytic site [active] 1052684009835 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1052684009836 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1052684009837 dimer interface [polypeptide binding]; other site 1052684009838 anticodon binding site; other site 1052684009839 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1052684009840 homodimer interface [polypeptide binding]; other site 1052684009841 motif 1; other site 1052684009842 active site 1052684009843 motif 2; other site 1052684009844 GAD domain; Region: GAD; pfam02938 1052684009845 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1052684009846 active site 1052684009847 motif 3; other site 1052684009848 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1052684009849 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052684009850 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 1052684009851 FMN binding site [chemical binding]; other site 1052684009852 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 1052684009853 substrate binding site [chemical binding]; other site 1052684009854 putative catalytic residue [active] 1052684009855 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052684009856 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1052684009857 hypothetical protein; Provisional; Region: PRK06194 1052684009858 classical (c) SDRs; Region: SDR_c; cd05233 1052684009859 NAD(P) binding site [chemical binding]; other site 1052684009860 active site 1052684009861 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052684009862 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052684009863 putative NADP binding site [chemical binding]; other site 1052684009864 active site 1052684009865 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684009866 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052684009867 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684009868 active site 1052684009869 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052684009870 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052684009871 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052684009872 putative NADP binding site [chemical binding]; other site 1052684009873 active site 1052684009874 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684009875 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052684009876 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684009877 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684009878 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052684009879 active site 1052684009880 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052684009881 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052684009882 substrate binding site [chemical binding]; other site 1052684009883 oxyanion hole (OAH) forming residues; other site 1052684009884 trimer interface [polypeptide binding]; other site 1052684009885 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052684009886 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684009887 active site 1052684009888 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052684009889 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052684009890 putative NADP binding site [chemical binding]; other site 1052684009891 KR domain; Region: KR; pfam08659 1052684009892 active site 1052684009893 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684009894 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684009895 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052684009896 active site 1052684009897 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052684009898 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052684009899 putative NADP binding site [chemical binding]; other site 1052684009900 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052684009901 active site 1052684009902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684009903 S-adenosylmethionine binding site [chemical binding]; other site 1052684009904 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052684009905 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684009906 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052684009907 active site 1052684009908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684009909 S-adenosylmethionine binding site [chemical binding]; other site 1052684009910 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052684009911 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684009912 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052684009913 active site 1052684009914 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052684009915 putative NADP binding site [chemical binding]; other site 1052684009916 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052684009917 active site 1052684009918 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052684009919 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684009920 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052684009921 active site 1052684009922 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052684009923 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052684009924 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052684009925 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684009926 active site 1052684009927 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052684009928 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052684009929 putative NADP binding site [chemical binding]; other site 1052684009930 KR domain; Region: KR; pfam08659 1052684009931 active site 1052684009932 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684009933 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052684009934 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684009935 active site 1052684009936 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 1052684009937 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052684009938 KR domain; Region: KR; pfam08659 1052684009939 putative NADP binding site [chemical binding]; other site 1052684009940 active site 1052684009941 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052684009942 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684009943 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052684009944 active site 1052684009945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684009946 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052684009947 acyl-CoA synthetase; Validated; Region: PRK05850 1052684009948 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1052684009949 acyl-activating enzyme (AAE) consensus motif; other site 1052684009950 active site 1052684009951 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684009952 Condensation domain; Region: Condensation; pfam00668 1052684009953 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684009954 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684009955 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 1052684009956 acyl-activating enzyme (AAE) consensus motif; other site 1052684009957 AMP binding site [chemical binding]; other site 1052684009958 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684009959 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684009960 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052684009961 active site 1052684009962 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 1052684009963 putative NADP binding site [chemical binding]; other site 1052684009964 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 1052684009965 active site 1052684009966 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052684009967 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684009968 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052684009969 active site 1052684009970 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684009971 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052684009972 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052684009973 substrate binding site [chemical binding]; other site 1052684009974 oxyanion hole (OAH) forming residues; other site 1052684009975 trimer interface [polypeptide binding]; other site 1052684009976 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1052684009977 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1052684009978 substrate binding site [chemical binding]; other site 1052684009979 oxyanion hole (OAH) forming residues; other site 1052684009980 trimer interface [polypeptide binding]; other site 1052684009981 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 1052684009982 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1052684009983 dimer interface [polypeptide binding]; other site 1052684009984 active site 1052684009985 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 1052684009986 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1052684009987 dimer interface [polypeptide binding]; other site 1052684009988 active site 1052684009989 acyl carrier protein; Validated; Region: PRK07117 1052684009990 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 1052684009991 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1052684009992 Transcription antiterminator [Transcription]; Region: NusG; COG0250 1052684009993 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 1052684009994 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1052684009995 heterodimer interface [polypeptide binding]; other site 1052684009996 homodimer interface [polypeptide binding]; other site 1052684009997 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1052684009998 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1052684009999 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1052684010000 dimer interface [polypeptide binding]; other site 1052684010001 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684010002 catalytic residue [active] 1052684010003 YolD-like protein; Region: YolD; pfam08863 1052684010004 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052684010005 hypothetical protein; Provisional; Region: PRK02237 1052684010006 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1052684010007 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1052684010008 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1052684010009 dimer interface [polypeptide binding]; other site 1052684010010 active site 1052684010011 metal binding site [ion binding]; metal-binding site 1052684010012 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1052684010013 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052684010014 Coenzyme A binding pocket [chemical binding]; other site 1052684010015 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 1052684010016 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1052684010017 dimer interface [polypeptide binding]; other site 1052684010018 active site 1052684010019 CoA binding pocket [chemical binding]; other site 1052684010020 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 1052684010021 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052684010022 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 1052684010023 Cupin; Region: Cupin_1; smart00835 1052684010024 Sm and related proteins; Region: Sm_like; cl00259 1052684010025 Sm1 motif; other site 1052684010026 hexamer interface [polypeptide binding]; other site 1052684010027 RNA binding site [nucleotide binding]; other site 1052684010028 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 1052684010029 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684010030 AMIN domain; Region: AMIN; pfam11741 1052684010031 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1052684010032 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1052684010033 active site 1052684010034 Predicted membrane protein [Function unknown]; Region: COG2855 1052684010035 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684010036 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684010037 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1052684010038 putative dimerization interface [polypeptide binding]; other site 1052684010039 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1052684010040 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1052684010041 inhibitor binding site; inhibition site 1052684010042 active site 1052684010043 Pectinesterase; Region: Pectinesterase; pfam01095 1052684010044 putative pectinesterase; Region: PLN02432; cl01911 1052684010045 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1052684010046 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1052684010047 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1052684010048 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 1052684010049 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684010050 Predicted integral membrane protein [Function unknown]; Region: COG5578 1052684010051 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684010052 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684010053 dimer interface [polypeptide binding]; other site 1052684010054 conserved gate region; other site 1052684010055 ABC-ATPase subunit interface; other site 1052684010056 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684010057 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684010058 dimer interface [polypeptide binding]; other site 1052684010059 conserved gate region; other site 1052684010060 putative PBP binding loops; other site 1052684010061 ABC-ATPase subunit interface; other site 1052684010062 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684010063 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684010064 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684010065 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1052684010066 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052684010067 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 1052684010068 active site 1052684010069 catalytic triad [active] 1052684010070 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1052684010071 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684010072 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1052684010073 FeS/SAM binding site; other site 1052684010074 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 1052684010075 Caspase domain; Region: Peptidase_C14; pfam00656 1052684010076 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684010077 non-specific DNA binding site [nucleotide binding]; other site 1052684010078 salt bridge; other site 1052684010079 sequence-specific DNA binding site [nucleotide binding]; other site 1052684010080 Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450 1052684010081 PGAP1-like protein; Region: PGAP1; pfam07819 1052684010082 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 1052684010083 Holin family; Region: Phage_holin_4; pfam05105 1052684010084 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1052684010085 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1052684010086 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 1052684010087 Baseplate J-like protein; Region: Baseplate_J; pfam04865 1052684010088 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 1052684010089 Phage-related minor tail protein [Function unknown]; Region: COG5280 1052684010090 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 1052684010091 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1052684010092 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 1052684010093 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1052684010094 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 1052684010095 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 1052684010096 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1052684010097 large terminase protein; Provisional; Region: 17; PHA02533 1052684010098 Uncharacterized conserved protein [Function unknown]; Region: COG5484 1052684010099 Phage terminase small subunit; Region: Phage_terminase; pfam10668 1052684010100 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1052684010101 ParB-like nuclease domain; Region: ParB; smart00470 1052684010102 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1052684010103 DNA methylase; Region: N6_N4_Mtase; pfam01555 1052684010104 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 1052684010105 metal binding triad [ion binding]; metal-binding site 1052684010106 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 1052684010107 replicative DNA helicase; Region: DnaB; TIGR00665 1052684010108 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1052684010109 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1052684010110 Walker A motif; other site 1052684010111 ATP binding site [chemical binding]; other site 1052684010112 Walker B motif; other site 1052684010113 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 1052684010114 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 1052684010115 RecT family; Region: RecT; cl04285 1052684010116 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 1052684010117 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684010118 non-specific DNA binding site [nucleotide binding]; other site 1052684010119 salt bridge; other site 1052684010120 sequence-specific DNA binding site [nucleotide binding]; other site 1052684010121 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052684010122 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684010123 non-specific DNA binding site [nucleotide binding]; other site 1052684010124 salt bridge; other site 1052684010125 sequence-specific DNA binding site [nucleotide binding]; other site 1052684010126 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052684010127 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684010128 non-specific DNA binding site [nucleotide binding]; other site 1052684010129 salt bridge; other site 1052684010130 sequence-specific DNA binding site [nucleotide binding]; other site 1052684010131 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1052684010132 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1052684010133 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1052684010134 Int/Topo IB signature motif; other site 1052684010135 HNH endonuclease; Region: HNH_2; pfam13391 1052684010136 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1052684010137 active site 1052684010138 8-oxo-dGMP binding site [chemical binding]; other site 1052684010139 nudix motif; other site 1052684010140 metal binding site [ion binding]; metal-binding site 1052684010141 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052684010142 active site 1052684010143 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1052684010144 active site 1052684010145 dimer interface [polypeptide binding]; other site 1052684010146 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1052684010147 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052684010148 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1052684010149 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1052684010150 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1052684010151 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1052684010152 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1052684010153 IMP binding site; other site 1052684010154 dimer interface [polypeptide binding]; other site 1052684010155 interdomain contacts; other site 1052684010156 partial ornithine binding site; other site 1052684010157 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1052684010158 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1052684010159 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1052684010160 catalytic site [active] 1052684010161 subunit interface [polypeptide binding]; other site 1052684010162 dihydroorotase; Validated; Region: pyrC; PRK09357 1052684010163 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052684010164 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1052684010165 active site 1052684010166 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1052684010167 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1052684010168 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1052684010169 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1052684010170 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052684010171 active site 1052684010172 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1052684010173 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052684010174 RNA binding surface [nucleotide binding]; other site 1052684010175 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1052684010176 active site 1052684010177 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1052684010178 lipoprotein signal peptidase; Provisional; Region: PRK14787 1052684010179 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 1052684010180 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1052684010181 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052684010182 active site 1052684010183 HIGH motif; other site 1052684010184 nucleotide binding site [chemical binding]; other site 1052684010185 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1052684010186 active site 1052684010187 KMSKS motif; other site 1052684010188 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1052684010189 tRNA binding surface [nucleotide binding]; other site 1052684010190 anticodon binding site; other site 1052684010191 DivIVA protein; Region: DivIVA; pfam05103 1052684010192 DivIVA domain; Region: DivI1A_domain; TIGR03544 1052684010193 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1052684010194 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1052684010195 RNA binding surface [nucleotide binding]; other site 1052684010196 YGGT family; Region: YGGT; pfam02325 1052684010197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1052684010198 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1052684010199 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052684010200 catalytic residue [active] 1052684010201 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1052684010202 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1052684010203 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 1052684010204 sporulation sigma factor SigG; Reviewed; Region: PRK08215 1052684010205 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684010206 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052684010207 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684010208 DNA binding residues [nucleotide binding] 1052684010209 sporulation sigma factor SigE; Reviewed; Region: PRK08301 1052684010210 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684010211 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684010212 DNA binding residues [nucleotide binding] 1052684010213 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 1052684010214 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 1052684010215 cell division protein FtsZ; Validated; Region: PRK09330 1052684010216 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1052684010217 nucleotide binding site [chemical binding]; other site 1052684010218 SulA interaction site; other site 1052684010219 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1052684010220 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052684010221 nucleotide binding site [chemical binding]; other site 1052684010222 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 1052684010223 Cell division protein FtsA; Region: FtsA; pfam14450 1052684010224 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1052684010225 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1052684010226 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1052684010227 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1052684010228 hinge; other site 1052684010229 active site 1052684010230 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1052684010231 FAD binding domain; Region: FAD_binding_4; pfam01565 1052684010232 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1052684010233 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1052684010234 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1052684010235 active site 1052684010236 homodimer interface [polypeptide binding]; other site 1052684010237 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1052684010238 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1052684010239 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052684010240 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052684010241 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1052684010242 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1052684010243 Mg++ binding site [ion binding]; other site 1052684010244 putative catalytic motif [active] 1052684010245 putative substrate binding site [chemical binding]; other site 1052684010246 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1052684010247 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1052684010248 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052684010249 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052684010250 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1052684010251 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1052684010252 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052684010253 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052684010254 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1052684010255 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052684010256 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052684010257 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 1052684010258 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 1052684010259 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052684010260 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052684010261 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1052684010262 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1052684010263 MraW methylase family; Region: Methyltransf_5; pfam01795 1052684010264 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1052684010265 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 1052684010266 MraZ protein; Region: MraZ; pfam02381 1052684010267 MraZ protein; Region: MraZ; pfam02381 1052684010268 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 1052684010269 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1052684010270 homotetramer interface [polypeptide binding]; other site 1052684010271 ligand binding site [chemical binding]; other site 1052684010272 catalytic site [active] 1052684010273 NAD binding site [chemical binding]; other site 1052684010274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 1052684010275 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 1052684010276 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1052684010277 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052684010278 Walker A/P-loop; other site 1052684010279 ATP binding site [chemical binding]; other site 1052684010280 Q-loop/lid; other site 1052684010281 ABC transporter signature motif; other site 1052684010282 Walker B; other site 1052684010283 D-loop; other site 1052684010284 H-loop/switch region; other site 1052684010285 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1052684010286 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052684010287 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052684010288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684010289 dimer interface [polypeptide binding]; other site 1052684010290 conserved gate region; other site 1052684010291 putative PBP binding loops; other site 1052684010292 ABC-ATPase subunit interface; other site 1052684010293 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052684010294 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684010295 dimer interface [polypeptide binding]; other site 1052684010296 conserved gate region; other site 1052684010297 putative PBP binding loops; other site 1052684010298 ABC-ATPase subunit interface; other site 1052684010299 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1052684010300 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1052684010301 peptide binding site [polypeptide binding]; other site 1052684010302 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1052684010303 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1052684010304 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1052684010305 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1052684010306 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 1052684010307 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1052684010308 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1052684010309 putative active site [active] 1052684010310 PhoH-like protein; Region: PhoH; pfam02562 1052684010311 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1052684010312 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1052684010313 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1052684010314 putative GEF interaction site [polypeptide binding]; other site 1052684010315 G1 box; other site 1052684010316 GTP/Mg2+ binding site [chemical binding]; other site 1052684010317 Switch I region; other site 1052684010318 G2 box; other site 1052684010319 G3 box; other site 1052684010320 Switch II region; other site 1052684010321 G4 box; other site 1052684010322 G5 box; other site 1052684010323 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1052684010324 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1052684010325 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1052684010326 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 1052684010327 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1052684010328 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1052684010329 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1052684010330 Ligand Binding Site [chemical binding]; other site 1052684010331 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1052684010332 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1052684010333 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052684010334 catalytic residue [active] 1052684010335 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1052684010336 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1052684010337 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052684010338 catalytic residue [active] 1052684010339 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 1052684010340 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 1052684010341 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 1052684010342 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1052684010343 active site 1052684010344 catalytic triad [active] 1052684010345 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052684010346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684010347 DNA-binding site [nucleotide binding]; DNA binding site 1052684010348 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684010349 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684010350 homodimer interface [polypeptide binding]; other site 1052684010351 catalytic residue [active] 1052684010352 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1052684010353 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684010354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684010355 homodimer interface [polypeptide binding]; other site 1052684010356 catalytic residue [active] 1052684010357 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1052684010358 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1052684010359 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1052684010360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1052684010361 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1052684010362 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1052684010363 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1052684010364 Family of unknown function (DUF633); Region: DUF633; pfam04816 1052684010365 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1052684010366 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1052684010367 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1052684010368 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684010369 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052684010370 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684010371 DNA binding residues [nucleotide binding] 1052684010372 DNA primase; Validated; Region: dnaG; PRK05667 1052684010373 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1052684010374 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1052684010375 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1052684010376 active site 1052684010377 metal binding site [ion binding]; metal-binding site 1052684010378 interdomain interaction site; other site 1052684010379 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1052684010380 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 1052684010381 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1052684010382 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1052684010383 dimer interface [polypeptide binding]; other site 1052684010384 motif 1; other site 1052684010385 active site 1052684010386 motif 2; other site 1052684010387 motif 3; other site 1052684010388 Recombination protein O N terminal; Region: RecO_N; pfam11967 1052684010389 DNA repair protein RecO; Region: reco; TIGR00613 1052684010390 Recombination protein O C terminal; Region: RecO_C; pfam02565 1052684010391 GTPase Era; Reviewed; Region: era; PRK00089 1052684010392 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1052684010393 G1 box; other site 1052684010394 GTP/Mg2+ binding site [chemical binding]; other site 1052684010395 Switch I region; other site 1052684010396 G2 box; other site 1052684010397 Switch II region; other site 1052684010398 G3 box; other site 1052684010399 G4 box; other site 1052684010400 G5 box; other site 1052684010401 KH domain; Region: KH_2; pfam07650 1052684010402 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 1052684010403 metal-binding heat shock protein; Provisional; Region: PRK00016 1052684010404 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 1052684010405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684010406 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052684010407 Zn2+ binding site [ion binding]; other site 1052684010408 Mg2+ binding site [ion binding]; other site 1052684010409 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1052684010410 PhoH-like protein; Region: PhoH; pfam02562 1052684010411 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 1052684010412 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 1052684010413 YabP family; Region: YabP; cl06766 1052684010414 amino acid transporter; Region: 2A0306; TIGR00909 1052684010415 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1052684010416 hypothetical protein; Provisional; Region: PRK13665 1052684010417 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 1052684010418 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1052684010419 dimer interface [polypeptide binding]; other site 1052684010420 active site residues [active] 1052684010421 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 1052684010422 Yqey-like protein; Region: YqeY; pfam09424 1052684010423 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1052684010424 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1052684010425 nucleotide binding site/active site [active] 1052684010426 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1052684010427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684010428 DNA-binding site [nucleotide binding]; DNA binding site 1052684010429 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684010430 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684010431 homodimer interface [polypeptide binding]; other site 1052684010432 catalytic residue [active] 1052684010433 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 1052684010434 AAA domain; Region: AAA_23; pfam13476 1052684010435 Walker A/P-loop; other site 1052684010436 ATP binding site [chemical binding]; other site 1052684010437 Q-loop/lid; other site 1052684010438 ABC transporter signature motif; other site 1052684010439 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 1052684010440 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684010441 ABC transporter signature motif; other site 1052684010442 Walker B; other site 1052684010443 D-loop; other site 1052684010444 H-loop/switch region; other site 1052684010445 exonuclease subunit SbcD; Provisional; Region: PRK10966 1052684010446 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1052684010447 active site 1052684010448 metal binding site [ion binding]; metal-binding site 1052684010449 DNA binding site [nucleotide binding] 1052684010450 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1052684010451 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1052684010452 Part of AAA domain; Region: AAA_19; pfam13245 1052684010453 Vi polysaccharide biosynthesis protein TviA; Provisional; Region: PRK15183 1052684010454 Family description; Region: UvrD_C_2; pfam13538 1052684010455 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1052684010456 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 1052684010457 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1052684010458 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1052684010459 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1052684010460 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1052684010461 putative RNA binding site [nucleotide binding]; other site 1052684010462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684010463 S-adenosylmethionine binding site [chemical binding]; other site 1052684010464 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1052684010465 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1052684010466 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1052684010467 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1052684010468 active site 1052684010469 Ap6A binding site [chemical binding]; other site 1052684010470 nudix motif; other site 1052684010471 metal binding site [ion binding]; metal-binding site 1052684010472 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 1052684010473 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1052684010474 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684010475 FeS/SAM binding site; other site 1052684010476 TRAM domain; Region: TRAM; cl01282 1052684010477 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1052684010478 RNA methyltransferase, RsmE family; Region: TIGR00046 1052684010479 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 1052684010480 Peptidase family M50; Region: Peptidase_M50; pfam02163 1052684010481 active site 1052684010482 putative substrate binding region [chemical binding]; other site 1052684010483 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1052684010484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684010485 S-adenosylmethionine binding site [chemical binding]; other site 1052684010486 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 1052684010487 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052684010488 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1052684010489 putative NAD(P) binding site [chemical binding]; other site 1052684010490 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 1052684010491 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1052684010492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684010493 active site 1052684010494 phosphorylation site [posttranslational modification] 1052684010495 intermolecular recognition site; other site 1052684010496 dimerization interface [polypeptide binding]; other site 1052684010497 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1052684010498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684010499 ATP binding site [chemical binding]; other site 1052684010500 Mg2+ binding site [ion binding]; other site 1052684010501 G-X-G motif; other site 1052684010502 chaperone protein DnaJ; Provisional; Region: PRK14280 1052684010503 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1052684010504 HSP70 interaction site [polypeptide binding]; other site 1052684010505 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1052684010506 substrate binding site [polypeptide binding]; other site 1052684010507 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1052684010508 Zn binding sites [ion binding]; other site 1052684010509 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1052684010510 dimer interface [polypeptide binding]; other site 1052684010511 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1052684010512 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1052684010513 nucleotide binding site [chemical binding]; other site 1052684010514 NEF interaction site [polypeptide binding]; other site 1052684010515 SBD interface [polypeptide binding]; other site 1052684010516 GrpE; Region: GrpE; pfam01025 1052684010517 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1052684010518 dimer interface [polypeptide binding]; other site 1052684010519 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1052684010520 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1052684010521 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1052684010522 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684010523 Coenzyme A binding pocket [chemical binding]; other site 1052684010524 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1052684010525 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684010526 FeS/SAM binding site; other site 1052684010527 HemN C-terminal domain; Region: HemN_C; pfam06969 1052684010528 GTP-binding protein LepA; Provisional; Region: PRK05433 1052684010529 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1052684010530 G1 box; other site 1052684010531 putative GEF interaction site [polypeptide binding]; other site 1052684010532 GTP/Mg2+ binding site [chemical binding]; other site 1052684010533 Switch I region; other site 1052684010534 G2 box; other site 1052684010535 G3 box; other site 1052684010536 Switch II region; other site 1052684010537 G4 box; other site 1052684010538 G5 box; other site 1052684010539 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1052684010540 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1052684010541 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1052684010542 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 1052684010543 stage II sporulation protein P; Region: spore_II_P; TIGR02867 1052684010544 germination protease; Provisional; Region: PRK02858 1052684010545 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1052684010546 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1052684010547 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1052684010548 Putative zinc-finger; Region: zf-HC2; pfam13490 1052684010549 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1052684010550 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684010551 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684010552 DNA binding residues [nucleotide binding] 1052684010553 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1052684010554 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1052684010555 Competence protein; Region: Competence; pfam03772 1052684010556 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1052684010557 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1052684010558 catalytic motif [active] 1052684010559 Zn binding site [ion binding]; other site 1052684010560 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1052684010561 Helix-hairpin-helix motif; Region: HHH; pfam00633 1052684010562 late competence protein ComER; Validated; Region: PRK07680 1052684010563 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1052684010564 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1052684010565 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1052684010566 HIGH motif; other site 1052684010567 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1052684010568 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052684010569 active site 1052684010570 KMSKS motif; other site 1052684010571 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1052684010572 tRNA binding surface [nucleotide binding]; other site 1052684010573 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 1052684010574 trimer interface [polypeptide binding]; other site 1052684010575 putative substrate binding pocket [chemical binding]; other site 1052684010576 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 1052684010577 active site 1 [active] 1052684010578 dimer interface [polypeptide binding]; other site 1052684010579 hexamer interface [polypeptide binding]; other site 1052684010580 active site 2 [active] 1052684010581 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1052684010582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684010583 S-adenosylmethionine binding site [chemical binding]; other site 1052684010584 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1052684010585 S1 domain; Region: S1_2; pfam13509 1052684010586 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052684010587 RNA binding site [nucleotide binding]; other site 1052684010588 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 1052684010589 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052684010590 Zn2+ binding site [ion binding]; other site 1052684010591 Mg2+ binding site [ion binding]; other site 1052684010592 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1052684010593 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1052684010594 active site 1052684010595 (T/H)XGH motif; other site 1052684010596 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1052684010597 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1052684010598 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1052684010599 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1052684010600 shikimate binding site; other site 1052684010601 NAD(P) binding site [chemical binding]; other site 1052684010602 GTPase YqeH; Provisional; Region: PRK13796 1052684010603 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1052684010604 GTP/Mg2+ binding site [chemical binding]; other site 1052684010605 G4 box; other site 1052684010606 G5 box; other site 1052684010607 G1 box; other site 1052684010608 Switch I region; other site 1052684010609 G2 box; other site 1052684010610 G3 box; other site 1052684010611 Switch II region; other site 1052684010612 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1052684010613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684010614 active site 1052684010615 motif I; other site 1052684010616 motif II; other site 1052684010617 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 1052684010618 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1052684010619 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1052684010620 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1052684010621 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1052684010622 Protein of unknown function DUF58; Region: DUF58; pfam01882 1052684010623 MoxR-like ATPases [General function prediction only]; Region: COG0714 1052684010624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684010625 Walker A motif; other site 1052684010626 ATP binding site [chemical binding]; other site 1052684010627 Walker B motif; other site 1052684010628 arginine finger; other site 1052684010629 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 1052684010630 stage V sporulation protein AD; Validated; Region: PRK08304 1052684010631 stage V sporulation protein AD; Provisional; Region: PRK12404 1052684010632 SpoVA protein; Region: SpoVA; cl04298 1052684010633 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1052684010634 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1052684010635 oligomer interface [polypeptide binding]; other site 1052684010636 active site 1052684010637 metal binding site [ion binding]; metal-binding site 1052684010638 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 1052684010639 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 1052684010640 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1052684010641 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684010642 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684010643 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684010644 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684010645 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1052684010646 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684010647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684010648 dimer interface [polypeptide binding]; other site 1052684010649 conserved gate region; other site 1052684010650 putative PBP binding loops; other site 1052684010651 ABC-ATPase subunit interface; other site 1052684010652 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684010653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684010654 dimer interface [polypeptide binding]; other site 1052684010655 conserved gate region; other site 1052684010656 ABC-ATPase subunit interface; other site 1052684010657 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1052684010658 extended (e) SDRs; Region: SDR_e; cd08946 1052684010659 NAD(P) binding site [chemical binding]; other site 1052684010660 active site 1052684010661 substrate binding site [chemical binding]; other site 1052684010662 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052684010663 EamA-like transporter family; Region: EamA; pfam00892 1052684010664 EamA-like transporter family; Region: EamA; pfam00892 1052684010665 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1052684010666 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1052684010667 putative active site [active] 1052684010668 Uncharacterized conserved protein [Function unknown]; Region: COG1683 1052684010669 sporulation sigma factor SigK; Reviewed; Region: PRK05803 1052684010670 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684010671 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684010672 DNA binding residues [nucleotide binding] 1052684010673 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052684010674 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684010675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684010676 putative substrate translocation pore; other site 1052684010677 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1052684010678 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1052684010679 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684010680 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684010681 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684010682 Interdomain contacts; other site 1052684010683 Cytokine receptor motif; other site 1052684010684 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684010685 Interdomain contacts; other site 1052684010686 Cytokine receptor motif; other site 1052684010687 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684010688 Interdomain contacts; other site 1052684010689 Cytokine receptor motif; other site 1052684010690 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684010691 Interdomain contacts; other site 1052684010692 Cytokine receptor motif; other site 1052684010693 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684010694 Interdomain contacts; other site 1052684010695 Cytokine receptor motif; other site 1052684010696 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684010697 Interdomain contacts; other site 1052684010698 Cytokine receptor motif; other site 1052684010699 S-layer homology domain; Region: SLH; pfam00395 1052684010700 S-layer homology domain; Region: SLH; pfam00395 1052684010701 S-layer homology domain; Region: SLH; pfam00395 1052684010702 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1052684010703 AAA domain; Region: AAA_33; pfam13671 1052684010704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1052684010705 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 1052684010706 Thg1 C terminal domain; Region: Thg1C; pfam14413 1052684010707 Uncharacterized conserved protein [Function unknown]; Region: COG5609 1052684010708 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1052684010709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684010710 dimer interface [polypeptide binding]; other site 1052684010711 ABC-ATPase subunit interface; other site 1052684010712 putative PBP binding loops; other site 1052684010713 PBP superfamily domain; Region: PBP_like_2; cl17296 1052684010714 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1052684010715 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1052684010716 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1052684010717 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1052684010718 ATP binding site [chemical binding]; other site 1052684010719 substrate interface [chemical binding]; other site 1052684010720 Ubiquitin-like proteins; Region: UBQ; cl00155 1052684010721 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1052684010722 MoaE homodimer interface [polypeptide binding]; other site 1052684010723 MoaD interaction [polypeptide binding]; other site 1052684010724 active site residues [active] 1052684010725 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1052684010726 MoaE interaction surface [polypeptide binding]; other site 1052684010727 MoeB interaction surface [polypeptide binding]; other site 1052684010728 thiocarboxylated glycine; other site 1052684010729 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1052684010730 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1052684010731 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684010732 FeS/SAM binding site; other site 1052684010733 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1052684010734 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 1052684010735 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1052684010736 catalytic loop [active] 1052684010737 iron binding site [ion binding]; other site 1052684010738 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1052684010739 4Fe-4S binding domain; Region: Fer4; pfam00037 1052684010740 4Fe-4S binding domain; Region: Fer4; pfam00037 1052684010741 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 1052684010742 [4Fe-4S] binding site [ion binding]; other site 1052684010743 molybdopterin cofactor binding site; other site 1052684010744 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1052684010745 molybdopterin cofactor binding site; other site 1052684010746 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1052684010747 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 1052684010748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 1052684010749 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684010750 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684010751 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684010752 dimerization interface [polypeptide binding]; other site 1052684010753 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684010754 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684010755 dimer interface [polypeptide binding]; other site 1052684010756 putative CheW interface [polypeptide binding]; other site 1052684010757 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1052684010758 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1052684010759 ligand binding site [chemical binding]; other site 1052684010760 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1052684010761 Cytochrome P450; Region: p450; pfam00067 1052684010762 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1052684010763 Flavodoxin; Region: Flavodoxin_1; pfam00258 1052684010764 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 1052684010765 FAD binding pocket [chemical binding]; other site 1052684010766 FAD binding motif [chemical binding]; other site 1052684010767 catalytic residues [active] 1052684010768 NAD binding pocket [chemical binding]; other site 1052684010769 phosphate binding motif [ion binding]; other site 1052684010770 beta-alpha-beta structure motif; other site 1052684010771 Restriction endonuclease; Region: Mrr_cat; pfam04471 1052684010772 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1052684010773 Aspartase; Region: Aspartase; cd01357 1052684010774 active sites [active] 1052684010775 tetramer interface [polypeptide binding]; other site 1052684010776 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684010777 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684010778 Coenzyme A binding pocket [chemical binding]; other site 1052684010779 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 1052684010780 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052684010781 aminotransferase A; Validated; Region: PRK07683 1052684010782 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684010783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684010784 homodimer interface [polypeptide binding]; other site 1052684010785 catalytic residue [active] 1052684010786 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1052684010787 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684010788 H-loop/switch region; other site 1052684010789 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1052684010790 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1052684010791 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684010792 dimer interface [polypeptide binding]; other site 1052684010793 conserved gate region; other site 1052684010794 putative PBP binding loops; other site 1052684010795 ABC-ATPase subunit interface; other site 1052684010796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684010797 dimer interface [polypeptide binding]; other site 1052684010798 conserved gate region; other site 1052684010799 putative PBP binding loops; other site 1052684010800 ABC-ATPase subunit interface; other site 1052684010801 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1052684010802 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684010803 Walker A/P-loop; other site 1052684010804 ATP binding site [chemical binding]; other site 1052684010805 Q-loop/lid; other site 1052684010806 ABC transporter signature motif; other site 1052684010807 Walker B; other site 1052684010808 D-loop; other site 1052684010809 H-loop/switch region; other site 1052684010810 TOBE domain; Region: TOBE_2; pfam08402 1052684010811 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1052684010812 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1052684010813 metal binding site [ion binding]; metal-binding site 1052684010814 putative dimer interface [polypeptide binding]; other site 1052684010815 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1052684010816 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1052684010817 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1052684010818 trimer interface [polypeptide binding]; other site 1052684010819 active site 1052684010820 substrate binding site [chemical binding]; other site 1052684010821 CoA binding site [chemical binding]; other site 1052684010822 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1052684010823 EamA-like transporter family; Region: EamA; pfam00892 1052684010824 EamA-like transporter family; Region: EamA; pfam00892 1052684010825 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1052684010826 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1052684010827 active site residue [active] 1052684010828 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1052684010829 active site residue [active] 1052684010830 Phosphotransferase enzyme family; Region: APH; pfam01636 1052684010831 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1052684010832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 1052684010833 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 1052684010834 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 1052684010835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684010836 S-adenosylmethionine binding site [chemical binding]; other site 1052684010837 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1052684010838 DinB superfamily; Region: DinB_2; pfam12867 1052684010839 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 1052684010840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684010841 S-adenosylmethionine binding site [chemical binding]; other site 1052684010842 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052684010843 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1052684010844 Phosphotransferase enzyme family; Region: APH; pfam01636 1052684010845 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1052684010846 active site 1052684010847 ATP binding site [chemical binding]; other site 1052684010848 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684010849 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684010850 Coenzyme A binding pocket [chemical binding]; other site 1052684010851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684010852 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1052684010853 Coenzyme A binding pocket [chemical binding]; other site 1052684010854 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684010855 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684010856 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1052684010857 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 1052684010858 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684010859 NAD(P) binding site [chemical binding]; other site 1052684010860 active site 1052684010861 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1052684010862 nudix motif; other site 1052684010863 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684010864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684010865 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684010866 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684010867 intersubunit interface [polypeptide binding]; other site 1052684010868 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 1052684010869 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1052684010870 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684010871 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1052684010872 siderophore binding site; other site 1052684010873 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 1052684010874 catalytic motif [active] 1052684010875 Catalytic residue [active] 1052684010876 Caspase domain; Region: Peptidase_C14; pfam00656 1052684010877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684010878 S-adenosylmethionine binding site [chemical binding]; other site 1052684010879 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052684010880 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684010881 S-adenosylmethionine binding site [chemical binding]; other site 1052684010882 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1052684010883 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052684010884 DNA binding site [nucleotide binding] 1052684010885 Int/Topo IB signature motif; other site 1052684010886 active site 1052684010887 Cache domain; Region: Cache_1; pfam02743 1052684010888 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684010889 dimerization interface [polypeptide binding]; other site 1052684010890 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684010891 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684010892 dimer interface [polypeptide binding]; other site 1052684010893 putative CheW interface [polypeptide binding]; other site 1052684010894 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1052684010895 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1052684010896 substrate binding pocket [chemical binding]; other site 1052684010897 chain length determination region; other site 1052684010898 substrate-Mg2+ binding site; other site 1052684010899 catalytic residues [active] 1052684010900 aspartate-rich region 1; other site 1052684010901 active site lid residues [active] 1052684010902 aspartate-rich region 2; other site 1052684010903 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052684010904 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052684010905 putative metal binding site [ion binding]; other site 1052684010906 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1052684010907 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1052684010908 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 1052684010909 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052684010910 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1052684010911 Protein of unknown function DUF2625; Region: DUF2625; cl08177 1052684010912 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1052684010913 active site 1052684010914 ATP binding site [chemical binding]; other site 1052684010915 substrate binding site [chemical binding]; other site 1052684010916 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684010917 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684010918 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684010919 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684010920 putative substrate translocation pore; other site 1052684010921 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1052684010922 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1052684010923 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 1052684010924 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684010925 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684010926 putative substrate translocation pore; other site 1052684010927 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 1052684010928 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684010929 dimerization interface [polypeptide binding]; other site 1052684010930 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684010931 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684010932 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684010933 dimer interface [polypeptide binding]; other site 1052684010934 putative CheW interface [polypeptide binding]; other site 1052684010935 S-layer homology domain; Region: SLH; pfam00395 1052684010936 S-layer homology domain; Region: SLH; pfam00395 1052684010937 S-layer homology domain; Region: SLH; pfam00395 1052684010938 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684010939 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684010940 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1052684010941 DinB superfamily; Region: DinB_2; pfam12867 1052684010942 metal-dependent hydrolase; Provisional; Region: PRK13291 1052684010943 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052684010944 putative active site [active] 1052684010945 heme pocket [chemical binding]; other site 1052684010946 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052684010947 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052684010948 metal binding site [ion binding]; metal-binding site 1052684010949 active site 1052684010950 I-site; other site 1052684010951 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052684010952 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684010953 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1052684010954 dimer interface [polypeptide binding]; other site 1052684010955 putative CheW interface [polypeptide binding]; other site 1052684010956 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052684010957 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052684010958 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052684010959 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052684010960 active site turn [active] 1052684010961 phosphorylation site [posttranslational modification] 1052684010962 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684010963 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052684010964 HPr interaction site; other site 1052684010965 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052684010966 active site 1052684010967 phosphorylation site [posttranslational modification] 1052684010968 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052684010969 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1052684010970 PRD domain; Region: PRD; pfam00874 1052684010971 PRD domain; Region: PRD; pfam00874 1052684010972 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 1052684010973 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684010974 FeS/SAM binding site; other site 1052684010975 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1052684010976 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1052684010977 MoaE interaction surface [polypeptide binding]; other site 1052684010978 MoeB interaction surface [polypeptide binding]; other site 1052684010979 thiocarboxylated glycine; other site 1052684010980 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1052684010981 MoaE homodimer interface [polypeptide binding]; other site 1052684010982 MoaD interaction [polypeptide binding]; other site 1052684010983 active site residues [active] 1052684010984 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1052684010985 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1052684010986 ATP binding site [chemical binding]; other site 1052684010987 substrate interface [chemical binding]; other site 1052684010988 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 1052684010989 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684010990 putative substrate translocation pore; other site 1052684010991 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052684010992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684010993 active site 1052684010994 phosphorylation site [posttranslational modification] 1052684010995 intermolecular recognition site; other site 1052684010996 dimerization interface [polypeptide binding]; other site 1052684010997 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052684010998 DNA binding residues [nucleotide binding] 1052684010999 dimerization interface [polypeptide binding]; other site 1052684011000 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 1052684011001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052684011002 Histidine kinase; Region: HisKA_3; pfam07730 1052684011003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684011004 ATP binding site [chemical binding]; other site 1052684011005 Mg2+ binding site [ion binding]; other site 1052684011006 G-X-G motif; other site 1052684011007 GAF domain; Region: GAF_3; pfam13492 1052684011008 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 1052684011009 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1052684011010 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1052684011011 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1052684011012 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1052684011013 [4Fe-4S] binding site [ion binding]; other site 1052684011014 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052684011015 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052684011016 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052684011017 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1052684011018 molybdopterin cofactor binding site; other site 1052684011019 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1052684011020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684011021 putative PBP binding loops; other site 1052684011022 ABC-ATPase subunit interface; other site 1052684011023 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 1052684011024 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1052684011025 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 1052684011026 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1052684011027 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1052684011028 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 1052684011029 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1052684011030 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 1052684011031 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684011032 FeS/SAM binding site; other site 1052684011033 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1052684011034 YwiC-like protein; Region: YwiC; pfam14256 1052684011035 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 1052684011036 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1052684011037 FtsZ protein binding site [polypeptide binding]; other site 1052684011038 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 1052684011039 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 1052684011040 transaminase; Reviewed; Region: PRK08068 1052684011041 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684011042 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684011043 homodimer interface [polypeptide binding]; other site 1052684011044 catalytic residue [active] 1052684011045 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1052684011046 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1052684011047 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1052684011048 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 1052684011049 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1052684011050 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1052684011051 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1052684011052 DNA binding site [nucleotide binding] 1052684011053 active site 1052684011054 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1052684011055 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1052684011056 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684011057 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684011058 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1052684011059 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1052684011060 tetramer interface [polypeptide binding]; other site 1052684011061 active site 1052684011062 Mg2+/Mn2+ binding site [ion binding]; other site 1052684011063 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 1052684011064 catalytic residue [active] 1052684011065 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684011066 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684011067 putative substrate translocation pore; other site 1052684011068 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684011069 putative DNA binding site [nucleotide binding]; other site 1052684011070 dimerization interface [polypeptide binding]; other site 1052684011071 putative Zn2+ binding site [ion binding]; other site 1052684011072 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1052684011073 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684011074 NAD(P) binding site [chemical binding]; other site 1052684011075 active site 1052684011076 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1052684011077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684011078 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684011079 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684011080 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684011081 DNA binding site [nucleotide binding] 1052684011082 domain linker motif; other site 1052684011083 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052684011084 ligand binding site [chemical binding]; other site 1052684011085 dimerization interface [polypeptide binding]; other site 1052684011086 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052684011087 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 1052684011088 putative NAD(P) binding site [chemical binding]; other site 1052684011089 catalytic Zn binding site [ion binding]; other site 1052684011090 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684011091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684011092 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 1052684011093 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 1052684011094 putative ligand binding residues [chemical binding]; other site 1052684011095 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1052684011096 Spore germination protein; Region: Spore_permease; cl17796 1052684011097 VanZ like family; Region: VanZ; pfam04892 1052684011098 RDD family; Region: RDD; pfam06271 1052684011099 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1052684011100 dimer interface [polypeptide binding]; other site 1052684011101 FMN binding site [chemical binding]; other site 1052684011102 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684011103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684011104 dimerization interface [polypeptide binding]; other site 1052684011105 putative DNA binding site [nucleotide binding]; other site 1052684011106 putative Zn2+ binding site [ion binding]; other site 1052684011107 glutamate dehydrogenase; Provisional; Region: PRK09414 1052684011108 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1052684011109 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1052684011110 NAD(P) binding site [chemical binding]; other site 1052684011111 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1052684011112 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1052684011113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684011114 catalytic residue [active] 1052684011115 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1052684011116 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 1052684011117 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684011118 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684011119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1052684011120 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684011121 Right handed beta helix region; Region: Beta_helix; pfam13229 1052684011122 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1052684011123 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 1052684011124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1052684011125 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1052684011126 DGC domain; Region: DGC; pfam08859 1052684011127 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1052684011128 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684011129 catalytic residue [active] 1052684011130 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684011131 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684011132 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052684011133 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1052684011134 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 1052684011135 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1052684011136 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 1052684011137 putative dimer interface [polypeptide binding]; other site 1052684011138 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052684011139 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 1052684011140 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1052684011141 conserved cys residue [active] 1052684011142 Predicted transcriptional regulator [Transcription]; Region: COG2378 1052684011143 HTH domain; Region: HTH_11; pfam08279 1052684011144 WYL domain; Region: WYL; pfam13280 1052684011145 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1052684011146 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1052684011147 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052684011148 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052684011149 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 1052684011150 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1052684011151 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 1052684011152 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1052684011153 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1052684011154 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1052684011155 Immunity protein Imm3; Region: Imm3; pfam14425 1052684011156 Immunity protein Imm3; Region: Imm3; pfam14425 1052684011157 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 1052684011158 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684011159 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684011160 dimer interface [polypeptide binding]; other site 1052684011161 conserved gate region; other site 1052684011162 putative PBP binding loops; other site 1052684011163 ABC-ATPase subunit interface; other site 1052684011164 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684011165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684011166 dimer interface [polypeptide binding]; other site 1052684011167 conserved gate region; other site 1052684011168 putative PBP binding loops; other site 1052684011169 ABC-ATPase subunit interface; other site 1052684011170 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684011171 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684011172 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684011173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684011174 active site 1052684011175 phosphorylation site [posttranslational modification] 1052684011176 intermolecular recognition site; other site 1052684011177 dimerization interface [polypeptide binding]; other site 1052684011178 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684011179 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684011180 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684011181 Histidine kinase; Region: His_kinase; pfam06580 1052684011182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684011183 ATP binding site [chemical binding]; other site 1052684011184 Mg2+ binding site [ion binding]; other site 1052684011185 G-X-G motif; other site 1052684011186 HEAT repeats; Region: HEAT_2; pfam13646 1052684011187 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1052684011188 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 1052684011189 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684011190 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684011191 DNA binding site [nucleotide binding] 1052684011192 domain linker motif; other site 1052684011193 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1052684011194 putative dimerization interface [polypeptide binding]; other site 1052684011195 putative ligand binding site [chemical binding]; other site 1052684011196 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1052684011197 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1052684011198 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1052684011199 Active_site [active] 1052684011200 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1052684011201 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052684011202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684011203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684011204 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1052684011205 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1052684011206 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 1052684011207 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 1052684011208 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1052684011209 Amb_all domain; Region: Amb_all; smart00656 1052684011210 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052684011211 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052684011212 Walker A/P-loop; other site 1052684011213 ATP binding site [chemical binding]; other site 1052684011214 Q-loop/lid; other site 1052684011215 ABC transporter signature motif; other site 1052684011216 Walker B; other site 1052684011217 D-loop; other site 1052684011218 H-loop/switch region; other site 1052684011219 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052684011220 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1052684011221 HAMP domain; Region: HAMP; pfam00672 1052684011222 dimerization interface [polypeptide binding]; other site 1052684011223 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684011224 dimer interface [polypeptide binding]; other site 1052684011225 phosphorylation site [posttranslational modification] 1052684011226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684011227 ATP binding site [chemical binding]; other site 1052684011228 Mg2+ binding site [ion binding]; other site 1052684011229 G-X-G motif; other site 1052684011230 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684011231 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684011232 active site 1052684011233 phosphorylation site [posttranslational modification] 1052684011234 intermolecular recognition site; other site 1052684011235 dimerization interface [polypeptide binding]; other site 1052684011236 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684011237 DNA binding site [nucleotide binding] 1052684011238 H-type lectin domain; Region: H_lectin; pfam09458 1052684011239 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 1052684011240 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 1052684011241 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 1052684011242 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 1052684011243 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1052684011244 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 1052684011245 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1052684011246 active site 1052684011247 catalytic triad [active] 1052684011248 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1052684011249 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684011250 Interdomain contacts; other site 1052684011251 Cytokine receptor motif; other site 1052684011252 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 1052684011253 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 1052684011254 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1052684011255 Cna protein B-type domain; Region: Cna_B_2; pfam13715 1052684011256 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 1052684011257 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 1052684011258 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 1052684011259 active site 1052684011260 catalytic triad [active] 1052684011261 putative transporter; Provisional; Region: PRK11660 1052684011262 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1052684011263 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1052684011264 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1052684011265 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684011266 dimerization interface [polypeptide binding]; other site 1052684011267 putative DNA binding site [nucleotide binding]; other site 1052684011268 putative Zn2+ binding site [ion binding]; other site 1052684011269 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1052684011270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684011271 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1052684011272 Walker A motif; other site 1052684011273 ATP binding site [chemical binding]; other site 1052684011274 Walker B motif; other site 1052684011275 arginine finger; other site 1052684011276 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684011277 putative substrate translocation pore; other site 1052684011278 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684011279 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052684011280 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052684011281 Walker A/P-loop; other site 1052684011282 ATP binding site [chemical binding]; other site 1052684011283 Q-loop/lid; other site 1052684011284 ABC transporter signature motif; other site 1052684011285 Walker B; other site 1052684011286 D-loop; other site 1052684011287 H-loop/switch region; other site 1052684011288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684011289 dimer interface [polypeptide binding]; other site 1052684011290 conserved gate region; other site 1052684011291 putative PBP binding loops; other site 1052684011292 ABC-ATPase subunit interface; other site 1052684011293 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052684011294 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052684011295 substrate binding pocket [chemical binding]; other site 1052684011296 membrane-bound complex binding site; other site 1052684011297 hinge residues; other site 1052684011298 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684011299 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052684011300 putative substrate translocation pore; other site 1052684011301 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1052684011302 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052684011303 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 1052684011304 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1052684011305 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1052684011306 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1052684011307 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1052684011308 Cellulose binding domain; Region: CBM_3; pfam00942 1052684011309 dihydroxyacetone kinase; Provisional; Region: PRK14479 1052684011310 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 1052684011311 DAK2 domain; Region: Dak2; pfam02734 1052684011312 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1052684011313 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1052684011314 dimer interface [polypeptide binding]; other site 1052684011315 active site 1052684011316 metal binding site [ion binding]; metal-binding site 1052684011317 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1052684011318 Sensory domain found in PocR; Region: PocR; pfam10114 1052684011319 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684011320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684011321 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684011322 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 1052684011323 RDD family; Region: RDD; pfam06271 1052684011324 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1052684011325 nucleotide binding site [chemical binding]; other site 1052684011326 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 1052684011327 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 1052684011328 active site 1052684011329 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1052684011330 phosphopeptide binding site; other site 1052684011331 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 1052684011332 phosphopeptide binding site; other site 1052684011333 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 1052684011334 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1052684011335 HSP70 interaction site [polypeptide binding]; other site 1052684011336 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1052684011337 metal ion-dependent adhesion site (MIDAS); other site 1052684011338 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1052684011339 active site 1052684011340 ATP binding site [chemical binding]; other site 1052684011341 substrate binding site [chemical binding]; other site 1052684011342 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1052684011343 activation loop (A-loop); other site 1052684011344 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1052684011345 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684011346 putative substrate translocation pore; other site 1052684011347 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1052684011348 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684011349 active site 1052684011350 phosphorylation site [posttranslational modification] 1052684011351 intermolecular recognition site; other site 1052684011352 dimerization interface [polypeptide binding]; other site 1052684011353 LytTr DNA-binding domain; Region: LytTR; smart00850 1052684011354 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1052684011355 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1052684011356 GAF domain; Region: GAF_3; pfam13492 1052684011357 Histidine kinase; Region: His_kinase; pfam06580 1052684011358 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684011359 ATP binding site [chemical binding]; other site 1052684011360 Mg2+ binding site [ion binding]; other site 1052684011361 G-X-G motif; other site 1052684011362 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1052684011363 putative dimer interface [polypeptide binding]; other site 1052684011364 catalytic triad [active] 1052684011365 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684011366 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684011367 dimer interface [polypeptide binding]; other site 1052684011368 putative CheW interface [polypeptide binding]; other site 1052684011369 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1052684011370 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1052684011371 5S rRNA interface [nucleotide binding]; other site 1052684011372 CTC domain interface [polypeptide binding]; other site 1052684011373 L16 interface [polypeptide binding]; other site 1052684011374 pullulanase, type I; Region: pulA_typeI; TIGR02104 1052684011375 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1052684011376 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1052684011377 Ca binding site [ion binding]; other site 1052684011378 active site 1052684011379 catalytic site [active] 1052684011380 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1052684011381 carbohydrate binding site [chemical binding]; other site 1052684011382 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1052684011383 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684011384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684011385 Walker A/P-loop; other site 1052684011386 ATP binding site [chemical binding]; other site 1052684011387 Q-loop/lid; other site 1052684011388 ABC transporter signature motif; other site 1052684011389 Walker B; other site 1052684011390 D-loop; other site 1052684011391 H-loop/switch region; other site 1052684011392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1052684011393 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684011394 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1052684011395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684011396 Walker A/P-loop; other site 1052684011397 ATP binding site [chemical binding]; other site 1052684011398 Q-loop/lid; other site 1052684011399 ABC transporter signature motif; other site 1052684011400 Walker B; other site 1052684011401 D-loop; other site 1052684011402 H-loop/switch region; other site 1052684011403 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1052684011404 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1052684011405 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1052684011406 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052684011407 active site 1052684011408 phosphorylation site [posttranslational modification] 1052684011409 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052684011410 HTH domain; Region: HTH_11; pfam08279 1052684011411 PRD domain; Region: PRD; pfam00874 1052684011412 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052684011413 active site 1052684011414 P-loop; other site 1052684011415 phosphorylation site [posttranslational modification] 1052684011416 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1052684011417 active site 1052684011418 phosphorylation site [posttranslational modification] 1052684011419 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1052684011420 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1052684011421 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1052684011422 active site 1052684011423 P-loop; other site 1052684011424 phosphorylation site [posttranslational modification] 1052684011425 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1052684011426 lipoyl attachment site [posttranslational modification]; other site 1052684011427 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1052684011428 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1052684011429 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 1052684011430 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1052684011431 tetramer interface [polypeptide binding]; other site 1052684011432 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684011433 catalytic residue [active] 1052684011434 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1052684011435 tetramer interface [polypeptide binding]; other site 1052684011436 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684011437 catalytic residue [active] 1052684011438 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1052684011439 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1052684011440 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1052684011441 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1052684011442 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1052684011443 dimerization domain swap beta strand [polypeptide binding]; other site 1052684011444 regulatory protein interface [polypeptide binding]; other site 1052684011445 active site 1052684011446 regulatory phosphorylation site [posttranslational modification]; other site 1052684011447 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684011448 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 1052684011449 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052684011450 active site turn [active] 1052684011451 phosphorylation site [posttranslational modification] 1052684011452 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052684011453 HPr interaction site; other site 1052684011454 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052684011455 active site 1052684011456 phosphorylation site [posttranslational modification] 1052684011457 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052684011458 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1052684011459 PRD domain; Region: PRD; pfam00874 1052684011460 PRD domain; Region: PRD; pfam00874 1052684011461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1052684011462 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1052684011463 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1052684011464 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1052684011465 dimer interface [polypeptide binding]; other site 1052684011466 active site 1052684011467 metal binding site [ion binding]; metal-binding site 1052684011468 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1052684011469 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1052684011470 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1052684011471 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1052684011472 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1052684011473 NAD binding site [chemical binding]; other site 1052684011474 homodimer interface [polypeptide binding]; other site 1052684011475 active site 1052684011476 substrate binding site [chemical binding]; other site 1052684011477 galactokinase; Provisional; Region: PRK05322 1052684011478 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1052684011479 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1052684011480 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052684011481 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684011482 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684011483 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684011484 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684011485 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052684011486 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052684011487 active site 1052684011488 catalytic tetrad [active] 1052684011489 NAD-dependent deacetylase; Provisional; Region: PRK00481 1052684011490 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1052684011491 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1052684011492 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684011493 motif II; other site 1052684011494 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1052684011495 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1052684011496 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1052684011497 General stress protein [General function prediction only]; Region: GsiB; COG3729 1052684011498 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1052684011499 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052684011500 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 1052684011501 NodB motif; other site 1052684011502 putative active site [active] 1052684011503 putative catalytic site [active] 1052684011504 putative Zn binding site [ion binding]; other site 1052684011505 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1052684011506 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052684011507 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1052684011508 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052684011509 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052684011510 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684011511 dimerization interface [polypeptide binding]; other site 1052684011512 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684011513 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684011514 dimer interface [polypeptide binding]; other site 1052684011515 putative CheW interface [polypeptide binding]; other site 1052684011516 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1052684011517 Peptidase family U32; Region: Peptidase_U32; pfam01136 1052684011518 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052684011519 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1052684011520 Peptidase family U32; Region: Peptidase_U32; pfam01136 1052684011521 YceG-like family; Region: YceG; pfam02618 1052684011522 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1052684011523 dimerization interface [polypeptide binding]; other site 1052684011524 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 1052684011525 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1052684011526 hypothetical protein; Provisional; Region: PRK05473 1052684011527 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1052684011528 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1052684011529 motif 1; other site 1052684011530 active site 1052684011531 motif 2; other site 1052684011532 motif 3; other site 1052684011533 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1052684011534 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1052684011535 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052684011536 Cache domain; Region: Cache_1; pfam02743 1052684011537 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1052684011538 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684011539 dimerization interface [polypeptide binding]; other site 1052684011540 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684011541 dimer interface [polypeptide binding]; other site 1052684011542 putative CheW interface [polypeptide binding]; other site 1052684011543 PRC-barrel domain; Region: PRC; pfam05239 1052684011544 PRC-barrel domain; Region: PRC; pfam05239 1052684011545 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1052684011546 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1052684011547 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052684011548 catalytic residue [active] 1052684011549 Predicted transcriptional regulator [Transcription]; Region: COG1959 1052684011550 Transcriptional regulator; Region: Rrf2; pfam02082 1052684011551 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1052684011552 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1052684011553 DinB superfamily; Region: DinB_2; pfam12867 1052684011554 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1052684011555 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1052684011556 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1052684011557 recombination factor protein RarA; Reviewed; Region: PRK13342 1052684011558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684011559 Walker A motif; other site 1052684011560 ATP binding site [chemical binding]; other site 1052684011561 Walker B motif; other site 1052684011562 arginine finger; other site 1052684011563 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1052684011564 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1052684011565 Part of AAA domain; Region: AAA_19; pfam13245 1052684011566 Family description; Region: UvrD_C_2; pfam13538 1052684011567 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684011568 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684011569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684011570 Walker A/P-loop; other site 1052684011571 ATP binding site [chemical binding]; other site 1052684011572 Q-loop/lid; other site 1052684011573 ABC transporter signature motif; other site 1052684011574 Walker B; other site 1052684011575 D-loop; other site 1052684011576 H-loop/switch region; other site 1052684011577 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1052684011578 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 1052684011579 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1052684011580 putative ATP binding site [chemical binding]; other site 1052684011581 putative substrate interface [chemical binding]; other site 1052684011582 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1052684011583 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1052684011584 dimer interface [polypeptide binding]; other site 1052684011585 anticodon binding site; other site 1052684011586 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1052684011587 homodimer interface [polypeptide binding]; other site 1052684011588 motif 1; other site 1052684011589 active site 1052684011590 motif 2; other site 1052684011591 GAD domain; Region: GAD; pfam02938 1052684011592 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1052684011593 motif 3; other site 1052684011594 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1052684011595 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1052684011596 dimer interface [polypeptide binding]; other site 1052684011597 motif 1; other site 1052684011598 active site 1052684011599 motif 2; other site 1052684011600 motif 3; other site 1052684011601 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1052684011602 anticodon binding site; other site 1052684011603 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1052684011604 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1052684011605 proposed catalytic triad [active] 1052684011606 conserved cys residue [active] 1052684011607 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1052684011608 putative active site [active] 1052684011609 dimerization interface [polypeptide binding]; other site 1052684011610 putative tRNAtyr binding site [nucleotide binding]; other site 1052684011611 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1052684011612 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052684011613 Zn2+ binding site [ion binding]; other site 1052684011614 Mg2+ binding site [ion binding]; other site 1052684011615 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052684011616 synthetase active site [active] 1052684011617 NTP binding site [chemical binding]; other site 1052684011618 metal binding site [ion binding]; metal-binding site 1052684011619 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1052684011620 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1052684011621 uracil transporter; Provisional; Region: PRK10720 1052684011622 Cache domain; Region: Cache_1; pfam02743 1052684011623 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1052684011624 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684011625 dimerization interface [polypeptide binding]; other site 1052684011626 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684011627 dimer interface [polypeptide binding]; other site 1052684011628 putative CheW interface [polypeptide binding]; other site 1052684011629 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052684011630 active site 1052684011631 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1052684011632 DHH family; Region: DHH; pfam01368 1052684011633 DHHA1 domain; Region: DHHA1; pfam02272 1052684011634 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 1052684011635 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1052684011636 Cation efflux family; Region: Cation_efflux; pfam01545 1052684011637 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1052684011638 Protein export membrane protein; Region: SecD_SecF; pfam02355 1052684011639 protein-export membrane protein SecD; Region: secD; TIGR01129 1052684011640 Class I aldolases; Region: Aldolase_Class_I; cl17187 1052684011641 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1052684011642 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 1052684011643 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1052684011644 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1052684011645 Predicted membrane protein [Function unknown]; Region: COG2323 1052684011646 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 1052684011647 Preprotein translocase subunit; Region: YajC; pfam02699 1052684011648 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1052684011649 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1052684011650 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1052684011651 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1052684011652 Stage II sporulation protein; Region: SpoIID; pfam08486 1052684011653 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1052684011654 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1052684011655 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684011656 Walker A motif; other site 1052684011657 ATP binding site [chemical binding]; other site 1052684011658 Walker B motif; other site 1052684011659 arginine finger; other site 1052684011660 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1052684011661 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1052684011662 RuvA N terminal domain; Region: RuvA_N; pfam01330 1052684011663 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1052684011664 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1052684011665 active site 1052684011666 putative DNA-binding cleft [nucleotide binding]; other site 1052684011667 dimer interface [polypeptide binding]; other site 1052684011668 BofC C-terminal domain; Region: BofC_C; pfam08955 1052684011669 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052684011670 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1052684011671 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052684011672 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1052684011673 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1052684011674 homodimer interface [polypeptide binding]; other site 1052684011675 substrate-cofactor binding pocket; other site 1052684011676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684011677 catalytic residue [active] 1052684011678 prephenate dehydratase; Provisional; Region: PRK11898 1052684011679 Prephenate dehydratase; Region: PDT; pfam00800 1052684011680 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1052684011681 putative L-Phe binding site [chemical binding]; other site 1052684011682 homoserine kinase; Provisional; Region: PRK01212 1052684011683 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1052684011684 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1052684011685 homoserine dehydrogenase; Provisional; Region: PRK06349 1052684011686 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1052684011687 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1052684011688 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1052684011689 hypothetical protein; Provisional; Region: PRK04435 1052684011690 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 1052684011691 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1052684011692 GTP1/OBG; Region: GTP1_OBG; pfam01018 1052684011693 Obg GTPase; Region: Obg; cd01898 1052684011694 G1 box; other site 1052684011695 GTP/Mg2+ binding site [chemical binding]; other site 1052684011696 Switch I region; other site 1052684011697 G2 box; other site 1052684011698 G3 box; other site 1052684011699 Switch II region; other site 1052684011700 G4 box; other site 1052684011701 G5 box; other site 1052684011702 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1052684011703 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1052684011704 Protein of unknown function (DUF464); Region: DUF464; pfam04327 1052684011705 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1052684011706 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1052684011707 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1052684011708 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1052684011709 homodimer interface [polypeptide binding]; other site 1052684011710 oligonucleotide binding site [chemical binding]; other site 1052684011711 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 1052684011712 Peptidase family M50; Region: Peptidase_M50; pfam02163 1052684011713 active site 1052684011714 putative substrate binding region [chemical binding]; other site 1052684011715 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052684011716 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 1052684011717 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1052684011718 Switch I; other site 1052684011719 Switch II; other site 1052684011720 septum formation inhibitor; Reviewed; Region: minC; PRK00513 1052684011721 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1052684011722 rod shape-determining protein MreD; Region: MreD; cl01087 1052684011723 rod shape-determining protein MreC; Provisional; Region: PRK13922 1052684011724 rod shape-determining protein MreC; Region: MreC; pfam04085 1052684011725 rod shape-determining protein MreB; Provisional; Region: PRK13927 1052684011726 MreB and similar proteins; Region: MreB_like; cd10225 1052684011727 nucleotide binding site [chemical binding]; other site 1052684011728 Mg binding site [ion binding]; other site 1052684011729 putative protofilament interaction site [polypeptide binding]; other site 1052684011730 RodZ interaction site [polypeptide binding]; other site 1052684011731 hypothetical protein; Reviewed; Region: PRK00024 1052684011732 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1052684011733 MPN+ (JAMM) motif; other site 1052684011734 Zinc-binding site [ion binding]; other site 1052684011735 Maf-like protein; Reviewed; Region: PRK00078 1052684011736 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1052684011737 active site 1052684011738 dimer interface [polypeptide binding]; other site 1052684011739 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 1052684011740 Sporulation related domain; Region: SPOR; pfam05036 1052684011741 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1052684011742 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1052684011743 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052684011744 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052684011745 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1052684011746 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1052684011747 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1052684011748 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1052684011749 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052684011750 active site 1052684011751 HIGH motif; other site 1052684011752 nucleotide binding site [chemical binding]; other site 1052684011753 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1052684011754 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1052684011755 active site 1052684011756 KMSKS motif; other site 1052684011757 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1052684011758 tRNA binding surface [nucleotide binding]; other site 1052684011759 anticodon binding site; other site 1052684011760 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1052684011761 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 1052684011762 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052684011763 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1052684011764 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1052684011765 active site 1052684011766 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1052684011767 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052684011768 inhibitor-cofactor binding pocket; inhibition site 1052684011769 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684011770 catalytic residue [active] 1052684011771 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1052684011772 dimer interface [polypeptide binding]; other site 1052684011773 active site 1052684011774 Schiff base residues; other site 1052684011775 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1052684011776 active site 1052684011777 SAM binding site [chemical binding]; other site 1052684011778 homodimer interface [polypeptide binding]; other site 1052684011779 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 1052684011780 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1052684011781 active site 1052684011782 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1052684011783 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1052684011784 domain interfaces; other site 1052684011785 active site 1052684011786 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 1052684011787 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1052684011788 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1052684011789 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1052684011790 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1052684011791 tRNA; other site 1052684011792 putative tRNA binding site [nucleotide binding]; other site 1052684011793 putative NADP binding site [chemical binding]; other site 1052684011794 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1052684011795 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 1052684011796 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1052684011797 G1 box; other site 1052684011798 GTP/Mg2+ binding site [chemical binding]; other site 1052684011799 Switch I region; other site 1052684011800 G2 box; other site 1052684011801 G3 box; other site 1052684011802 Switch II region; other site 1052684011803 G4 box; other site 1052684011804 G5 box; other site 1052684011805 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 1052684011806 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684011807 Walker A motif; other site 1052684011808 ATP binding site [chemical binding]; other site 1052684011809 Walker B motif; other site 1052684011810 arginine finger; other site 1052684011811 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1052684011812 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 1052684011813 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684011814 Walker A motif; other site 1052684011815 ATP binding site [chemical binding]; other site 1052684011816 Walker B motif; other site 1052684011817 arginine finger; other site 1052684011818 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1052684011819 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1052684011820 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1052684011821 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1052684011822 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1052684011823 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1052684011824 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684011825 Walker A motif; other site 1052684011826 ATP binding site [chemical binding]; other site 1052684011827 Walker B motif; other site 1052684011828 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1052684011829 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1052684011830 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1052684011831 oligomer interface [polypeptide binding]; other site 1052684011832 active site residues [active] 1052684011833 trigger factor; Provisional; Region: tig; PRK01490 1052684011834 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1052684011835 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1052684011836 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1052684011837 active site 1052684011838 putative catalytic site [active] 1052684011839 DNA binding site [nucleotide binding] 1052684011840 putative phosphate binding site [ion binding]; other site 1052684011841 metal binding site A [ion binding]; metal-binding site 1052684011842 AP binding site [nucleotide binding]; other site 1052684011843 metal binding site B [ion binding]; metal-binding site 1052684011844 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1052684011845 beta-galactosidase; Region: BGL; TIGR03356 1052684011846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1052684011847 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684011848 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684011849 DNA binding site [nucleotide binding] 1052684011850 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052684011851 dimerization interface [polypeptide binding]; other site 1052684011852 ligand binding site [chemical binding]; other site 1052684011853 glycerol kinase; Provisional; Region: glpK; PRK00047 1052684011854 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1052684011855 N- and C-terminal domain interface [polypeptide binding]; other site 1052684011856 active site 1052684011857 MgATP binding site [chemical binding]; other site 1052684011858 catalytic site [active] 1052684011859 metal binding site [ion binding]; metal-binding site 1052684011860 glycerol binding site [chemical binding]; other site 1052684011861 homotetramer interface [polypeptide binding]; other site 1052684011862 homodimer interface [polypeptide binding]; other site 1052684011863 FBP binding site [chemical binding]; other site 1052684011864 protein IIAGlc interface [polypeptide binding]; other site 1052684011865 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1052684011866 amphipathic channel; other site 1052684011867 Asn-Pro-Ala signature motifs; other site 1052684011868 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 1052684011869 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684011870 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052684011871 active site turn [active] 1052684011872 phosphorylation site [posttranslational modification] 1052684011873 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684011874 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684011875 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684011876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684011877 dimer interface [polypeptide binding]; other site 1052684011878 ABC-ATPase subunit interface; other site 1052684011879 putative PBP binding loops; other site 1052684011880 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684011881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684011882 dimer interface [polypeptide binding]; other site 1052684011883 conserved gate region; other site 1052684011884 putative PBP binding loops; other site 1052684011885 ABC-ATPase subunit interface; other site 1052684011886 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 1052684011887 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684011888 FeS/SAM binding site; other site 1052684011889 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 1052684011890 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684011891 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052684011892 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1052684011893 Walker A/P-loop; other site 1052684011894 ATP binding site [chemical binding]; other site 1052684011895 Q-loop/lid; other site 1052684011896 ABC transporter signature motif; other site 1052684011897 Walker B; other site 1052684011898 D-loop; other site 1052684011899 H-loop/switch region; other site 1052684011900 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1052684011901 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 1052684011902 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684011903 FeS/SAM binding site; other site 1052684011904 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1052684011905 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1052684011906 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684011907 active site 1052684011908 phosphorylation site [posttranslational modification] 1052684011909 intermolecular recognition site; other site 1052684011910 dimerization interface [polypeptide binding]; other site 1052684011911 LytTr DNA-binding domain; Region: LytTR; smart00850 1052684011912 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1052684011913 ATP binding site [chemical binding]; other site 1052684011914 Mg2+ binding site [ion binding]; other site 1052684011915 G-X-G motif; other site 1052684011916 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052684011917 amino acid carrier protein; Region: agcS; TIGR00835 1052684011918 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1052684011919 beta-galactosidase; Region: BGL; TIGR03356 1052684011920 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684011921 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684011922 DNA binding site [nucleotide binding] 1052684011923 domain linker motif; other site 1052684011924 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052684011925 CAT RNA binding domain; Region: CAT_RBD; smart01061 1052684011926 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052684011927 PRD domain; Region: PRD; pfam00874 1052684011928 PRD domain; Region: PRD; pfam00874 1052684011929 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 1052684011930 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052684011931 active site turn [active] 1052684011932 phosphorylation site [posttranslational modification] 1052684011933 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684011934 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052684011935 HPr interaction site; other site 1052684011936 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052684011937 active site 1052684011938 phosphorylation site [posttranslational modification] 1052684011939 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052684011940 catalytic residues [active] 1052684011941 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052684011942 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 1052684011943 active site 1052684011944 Cupin domain; Region: Cupin_2; cl17218 1052684011945 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684011946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684011947 active site 1052684011948 phosphorylation site [posttranslational modification] 1052684011949 intermolecular recognition site; other site 1052684011950 dimerization interface [polypeptide binding]; other site 1052684011951 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684011952 DNA binding site [nucleotide binding] 1052684011953 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684011954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684011955 active site 1052684011956 phosphorylation site [posttranslational modification] 1052684011957 intermolecular recognition site; other site 1052684011958 dimerization interface [polypeptide binding]; other site 1052684011959 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1052684011960 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052684011961 active site 1052684011962 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052684011963 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684011964 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052684011965 active site 1052684011966 malate dehydrogenase; Provisional; Region: PRK13529 1052684011967 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1052684011968 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1052684011969 NAD(P) binding site [chemical binding]; other site 1052684011970 Putative transcription activator [Transcription]; Region: TenA; COG0819 1052684011971 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1052684011972 substrate binding site [chemical binding]; other site 1052684011973 multimerization interface [polypeptide binding]; other site 1052684011974 ATP binding site [chemical binding]; other site 1052684011975 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1052684011976 dimer interface [polypeptide binding]; other site 1052684011977 substrate binding site [chemical binding]; other site 1052684011978 ATP binding site [chemical binding]; other site 1052684011979 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1052684011980 thiamine phosphate binding site [chemical binding]; other site 1052684011981 active site 1052684011982 pyrophosphate binding site [ion binding]; other site 1052684011983 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684011984 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684011985 dimerization interface [polypeptide binding]; other site 1052684011986 putative DNA binding site [nucleotide binding]; other site 1052684011987 putative Zn2+ binding site [ion binding]; other site 1052684011988 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 1052684011989 active site 1052684011990 Mn binding site [ion binding]; other site 1052684011991 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684011992 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684011993 DNA binding site [nucleotide binding] 1052684011994 domain linker motif; other site 1052684011995 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052684011996 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1052684011997 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1052684011998 NAD binding site [chemical binding]; other site 1052684011999 sugar binding site [chemical binding]; other site 1052684012000 divalent metal binding site [ion binding]; other site 1052684012001 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052684012002 dimer interface [polypeptide binding]; other site 1052684012003 Tic20-like protein; Region: Tic20; pfam09685 1052684012004 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1052684012005 active site 1052684012006 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 1052684012007 dimer interface [polypeptide binding]; other site 1052684012008 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1052684012009 Ligand Binding Site [chemical binding]; other site 1052684012010 Molecular Tunnel; other site 1052684012011 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1052684012012 active site 1052684012013 dimerization interface [polypeptide binding]; other site 1052684012014 ribonuclease PH; Reviewed; Region: rph; PRK00173 1052684012015 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1052684012016 hexamer interface [polypeptide binding]; other site 1052684012017 active site 1052684012018 Spore germination protein [General function prediction only]; Region: COG5401 1052684012019 Sporulation and spore germination; Region: Germane; pfam10646 1052684012020 Sporulation and spore germination; Region: Germane; pfam10646 1052684012021 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1052684012022 tetramer interfaces [polypeptide binding]; other site 1052684012023 binuclear metal-binding site [ion binding]; other site 1052684012024 putative acetyltransferase; Provisional; Region: PRK03624 1052684012025 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684012026 Coenzyme A binding pocket [chemical binding]; other site 1052684012027 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1052684012028 classical (c) SDRs; Region: SDR_c; cd05233 1052684012029 NAD(P) binding site [chemical binding]; other site 1052684012030 active site 1052684012031 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684012032 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684012033 WHG domain; Region: WHG; pfam13305 1052684012034 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1052684012035 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052684012036 NAD binding site [chemical binding]; other site 1052684012037 substrate binding site [chemical binding]; other site 1052684012038 putative active site [active] 1052684012039 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052684012040 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684012041 S-adenosylmethionine binding site [chemical binding]; other site 1052684012042 Protein of unknown function DUF72; Region: DUF72; pfam01904 1052684012043 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1052684012044 putative metal binding site; other site 1052684012045 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052684012046 binding surface 1052684012047 TPR motif; other site 1052684012048 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1052684012049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684012050 S-adenosylmethionine binding site [chemical binding]; other site 1052684012051 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1052684012052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684012053 NAD(P) binding site [chemical binding]; other site 1052684012054 active site 1052684012055 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1052684012056 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1052684012057 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1052684012058 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1052684012059 NAD(P) binding site [chemical binding]; other site 1052684012060 homodimer interface [polypeptide binding]; other site 1052684012061 substrate binding site [chemical binding]; other site 1052684012062 active site 1052684012063 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 1052684012064 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 1052684012065 active site 1052684012066 catalytic triad [active] 1052684012067 oxyanion hole [active] 1052684012068 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684012069 dimerization interface [polypeptide binding]; other site 1052684012070 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684012071 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684012072 dimer interface [polypeptide binding]; other site 1052684012073 putative CheW interface [polypeptide binding]; other site 1052684012074 Putative motility protein; Region: YjfB_motility; pfam14070 1052684012075 hypothetical protein; Provisional; Region: PRK08201 1052684012076 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 1052684012077 metal binding site [ion binding]; metal-binding site 1052684012078 putative dimer interface [polypeptide binding]; other site 1052684012079 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1052684012080 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1052684012081 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052684012082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052684012083 DNA binding residues [nucleotide binding] 1052684012084 dimerization interface [polypeptide binding]; other site 1052684012085 Imelysin; Region: Peptidase_M75; pfam09375 1052684012086 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1052684012087 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1052684012088 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 1052684012089 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 1052684012090 dimer interface [polypeptide binding]; other site 1052684012091 active site 1052684012092 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1052684012093 catalytic residues [active] 1052684012094 substrate binding site [chemical binding]; other site 1052684012095 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052684012096 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684012097 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1052684012098 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 1052684012099 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1052684012100 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1052684012101 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1052684012102 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1052684012103 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684012104 Walker A/P-loop; other site 1052684012105 ATP binding site [chemical binding]; other site 1052684012106 Q-loop/lid; other site 1052684012107 ABC transporter signature motif; other site 1052684012108 Walker B; other site 1052684012109 D-loop; other site 1052684012110 H-loop/switch region; other site 1052684012111 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684012112 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1052684012113 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684012114 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1052684012115 FeS/SAM binding site; other site 1052684012116 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1052684012117 acyl carrier protein; Provisional; Region: PRK07081 1052684012118 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1052684012119 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1052684012120 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1052684012121 putative active site [active] 1052684012122 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1052684012123 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1052684012124 active site 1052684012125 trimer interface [polypeptide binding]; other site 1052684012126 allosteric site; other site 1052684012127 active site lid [active] 1052684012128 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052684012129 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1052684012130 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1052684012131 active site 1052684012132 dimer interface [polypeptide binding]; other site 1052684012133 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052684012134 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 1052684012135 PGAP1-like protein; Region: PGAP1; pfam07819 1052684012136 RNA polymerase sigma-F factor; Region: spore_sigF; TIGR02885 1052684012137 YvrJ protein family; Region: YvrJ; pfam12841 1052684012138 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 1052684012139 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1052684012140 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1052684012141 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052684012142 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052684012143 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052684012144 Walker A/P-loop; other site 1052684012145 ATP binding site [chemical binding]; other site 1052684012146 Q-loop/lid; other site 1052684012147 ABC transporter signature motif; other site 1052684012148 Walker B; other site 1052684012149 D-loop; other site 1052684012150 H-loop/switch region; other site 1052684012151 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052684012152 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684012153 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052684012154 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1052684012155 HPr interaction site; other site 1052684012156 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052684012157 active site 1052684012158 phosphorylation site [posttranslational modification] 1052684012159 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684012160 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1052684012161 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052684012162 active site turn [active] 1052684012163 phosphorylation site [posttranslational modification] 1052684012164 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1052684012165 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684012166 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684012167 DNA binding site [nucleotide binding] 1052684012168 domain linker motif; other site 1052684012169 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1052684012170 ligand binding site [chemical binding]; other site 1052684012171 dimerization interface [polypeptide binding]; other site 1052684012172 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1052684012173 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052684012174 Rrf2 family protein; Region: rrf2_super; TIGR00738 1052684012175 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684012176 putative Zn2+ binding site [ion binding]; other site 1052684012177 putative DNA binding site [nucleotide binding]; other site 1052684012178 dimerization interface [polypeptide binding]; other site 1052684012179 HTH domain; Region: HTH_11; pfam08279 1052684012180 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052684012181 Mga helix-turn-helix domain; Region: Mga; pfam05043 1052684012182 PRD domain; Region: PRD; pfam00874 1052684012183 PRD domain; Region: PRD; pfam00874 1052684012184 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052684012185 active site 1052684012186 P-loop; other site 1052684012187 phosphorylation site [posttranslational modification] 1052684012188 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052684012189 active site 1052684012190 phosphorylation site [posttranslational modification] 1052684012191 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1052684012192 active site 1052684012193 methionine cluster; other site 1052684012194 phosphorylation site [posttranslational modification] 1052684012195 metal binding site [ion binding]; metal-binding site 1052684012196 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1052684012197 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052684012198 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1052684012199 beta-galactosidase; Region: BGL; TIGR03356 1052684012200 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1052684012201 active site 1052684012202 P-loop; other site 1052684012203 phosphorylation site [posttranslational modification] 1052684012204 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1052684012205 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684012206 NAD(P) binding site [chemical binding]; other site 1052684012207 active site 1052684012208 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684012209 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052684012210 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1052684012211 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052684012212 active site 1052684012213 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1052684012214 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1052684012215 Probable Catalytic site; other site 1052684012216 metal-binding site 1052684012217 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1052684012218 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052684012219 active site 1052684012220 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684012221 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1052684012222 NAD(P) binding site [chemical binding]; other site 1052684012223 active site 1052684012224 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 1052684012225 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1052684012226 NADP binding site [chemical binding]; other site 1052684012227 active site 1052684012228 putative substrate binding site [chemical binding]; other site 1052684012229 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1052684012230 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1052684012231 NAD(P) binding site [chemical binding]; other site 1052684012232 homodimer interface [polypeptide binding]; other site 1052684012233 substrate binding site [chemical binding]; other site 1052684012234 active site 1052684012235 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1052684012236 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1052684012237 active site 1052684012238 homodimer interface [polypeptide binding]; other site 1052684012239 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052684012240 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684012241 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1052684012242 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1052684012243 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 1052684012244 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1052684012245 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1052684012246 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052684012247 active site 1052684012248 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052684012249 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1052684012250 active site 1052684012251 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 1052684012252 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1052684012253 Probable Catalytic site; other site 1052684012254 metal-binding site 1052684012255 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052684012256 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052684012257 active site 1052684012258 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052684012259 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1052684012260 active site 1052684012261 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 1052684012262 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 1052684012263 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 1052684012264 active site 1052684012265 Zn binding site [ion binding]; other site 1052684012266 TraX protein; Region: TraX; cl05434 1052684012267 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052684012268 Histidine kinase; Region: HisKA_3; pfam07730 1052684012269 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684012270 ATP binding site [chemical binding]; other site 1052684012271 Mg2+ binding site [ion binding]; other site 1052684012272 G-X-G motif; other site 1052684012273 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052684012274 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684012275 active site 1052684012276 phosphorylation site [posttranslational modification] 1052684012277 intermolecular recognition site; other site 1052684012278 dimerization interface [polypeptide binding]; other site 1052684012279 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052684012280 DNA binding residues [nucleotide binding] 1052684012281 dimerization interface [polypeptide binding]; other site 1052684012282 Putative sensor; Region: Sensor; pfam13796 1052684012283 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1052684012284 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684012285 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1052684012286 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1052684012287 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684012288 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684012289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684012290 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1052684012291 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1052684012292 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684012293 homodimer interface [polypeptide binding]; other site 1052684012294 catalytic residue [active] 1052684012295 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1052684012296 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684012297 dimer interface [polypeptide binding]; other site 1052684012298 phosphorylation site [posttranslational modification] 1052684012299 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684012300 ATP binding site [chemical binding]; other site 1052684012301 Mg2+ binding site [ion binding]; other site 1052684012302 G-X-G motif; other site 1052684012303 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 1052684012304 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1052684012305 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052684012306 Walker A/P-loop; other site 1052684012307 ATP binding site [chemical binding]; other site 1052684012308 Q-loop/lid; other site 1052684012309 ABC transporter signature motif; other site 1052684012310 Walker B; other site 1052684012311 D-loop; other site 1052684012312 H-loop/switch region; other site 1052684012313 helicase 45; Provisional; Region: PTZ00424 1052684012314 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052684012315 ATP binding site [chemical binding]; other site 1052684012316 Mg++ binding site [ion binding]; other site 1052684012317 motif III; other site 1052684012318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684012319 nucleotide binding region [chemical binding]; other site 1052684012320 ATP-binding site [chemical binding]; other site 1052684012321 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1052684012322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684012323 NAD(P) binding site [chemical binding]; other site 1052684012324 active site 1052684012325 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 1052684012326 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 1052684012327 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684012328 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684012329 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684012330 dimerization interface [polypeptide binding]; other site 1052684012331 histidinol-phosphatase; Provisional; Region: PRK07328 1052684012332 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 1052684012333 active site 1052684012334 dimer interface [polypeptide binding]; other site 1052684012335 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1052684012336 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1052684012337 synthetase active site [active] 1052684012338 NTP binding site [chemical binding]; other site 1052684012339 metal binding site [ion binding]; metal-binding site 1052684012340 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1052684012341 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1052684012342 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052684012343 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1052684012344 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1052684012345 active site 1052684012346 metal binding site [ion binding]; metal-binding site 1052684012347 phosphodiesterase YaeI; Provisional; Region: PRK11340 1052684012348 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1052684012349 putative active site [active] 1052684012350 putative metal binding site [ion binding]; other site 1052684012351 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 1052684012352 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1052684012353 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1052684012354 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1052684012355 L-aspartate oxidase; Provisional; Region: PRK06175 1052684012356 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1052684012357 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1052684012358 putative Iron-sulfur protein interface [polypeptide binding]; other site 1052684012359 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1052684012360 proximal heme binding site [chemical binding]; other site 1052684012361 distal heme binding site [chemical binding]; other site 1052684012362 putative dimer interface [polypeptide binding]; other site 1052684012363 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684012364 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684012365 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684012366 dimerization interface [polypeptide binding]; other site 1052684012367 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052684012368 TrkA-N domain; Region: TrkA_N; pfam02254 1052684012369 TrkA-C domain; Region: TrkA_C; pfam02080 1052684012370 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1052684012371 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1052684012372 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1052684012373 CAAX protease self-immunity; Region: Abi; pfam02517 1052684012374 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 1052684012375 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1052684012376 GIY-YIG motif/motif A; other site 1052684012377 active site 1052684012378 catalytic site [active] 1052684012379 putative DNA binding site [nucleotide binding]; other site 1052684012380 metal binding site [ion binding]; metal-binding site 1052684012381 UvrB/uvrC motif; Region: UVR; pfam02151 1052684012382 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1052684012383 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052684012384 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1052684012385 catalytic residues [active] 1052684012386 primosomal protein DnaI; Reviewed; Region: PRK08939 1052684012387 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1052684012388 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684012389 Walker A motif; other site 1052684012390 ATP binding site [chemical binding]; other site 1052684012391 Walker B motif; other site 1052684012392 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1052684012393 putative heme peroxidase; Provisional; Region: PRK12276 1052684012394 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1052684012395 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1052684012396 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1052684012397 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1052684012398 Outer membrane efflux protein; Region: OEP; pfam02321 1052684012399 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052684012400 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684012401 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684012402 putative DNA binding site [nucleotide binding]; other site 1052684012403 putative Zn2+ binding site [ion binding]; other site 1052684012404 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1052684012405 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684012406 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1052684012407 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052684012408 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684012409 Sporulation inhibitor A; Region: Sda; pfam08970 1052684012410 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1052684012411 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1052684012412 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1052684012413 polyphosphate kinase; Provisional; Region: PRK05443 1052684012414 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1052684012415 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1052684012416 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1052684012417 putative domain interface [polypeptide binding]; other site 1052684012418 putative active site [active] 1052684012419 catalytic site [active] 1052684012420 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1052684012421 putative domain interface [polypeptide binding]; other site 1052684012422 putative active site [active] 1052684012423 catalytic site [active] 1052684012424 hypothetical protein; Provisional; Region: PRK08236 1052684012425 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 1052684012426 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1052684012427 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 1052684012428 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052684012429 EamA-like transporter family; Region: EamA; pfam00892 1052684012430 EamA-like transporter family; Region: EamA; pfam00892 1052684012431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684012432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684012433 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684012434 dimerization interface [polypeptide binding]; other site 1052684012435 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1052684012436 S-layer homology domain; Region: SLH; pfam00395 1052684012437 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1052684012438 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 1052684012439 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684012440 FeS/SAM binding site; other site 1052684012441 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1052684012442 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684012443 hypothetical protein; Provisional; Region: PRK13669 1052684012444 NifU-like domain; Region: NifU; cl00484 1052684012445 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 1052684012446 classical (c) SDRs; Region: SDR_c; cd05233 1052684012447 NAD(P) binding site [chemical binding]; other site 1052684012448 active site 1052684012449 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1052684012450 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1052684012451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684012452 dimer interface [polypeptide binding]; other site 1052684012453 conserved gate region; other site 1052684012454 ABC-ATPase subunit interface; other site 1052684012455 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1052684012456 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1052684012457 Walker A/P-loop; other site 1052684012458 ATP binding site [chemical binding]; other site 1052684012459 Q-loop/lid; other site 1052684012460 ABC transporter signature motif; other site 1052684012461 Walker B; other site 1052684012462 D-loop; other site 1052684012463 H-loop/switch region; other site 1052684012464 NIL domain; Region: NIL; pfam09383 1052684012465 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1052684012466 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1052684012467 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 1052684012468 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 1052684012469 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052684012470 catalytic residues [active] 1052684012471 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 1052684012472 stage V sporulation protein B; Region: spore_V_B; TIGR02900 1052684012473 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1052684012474 Protein of unknown function (DUF456); Region: DUF456; pfam04306 1052684012475 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1052684012476 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684012477 active site 1052684012478 motif I; other site 1052684012479 motif II; other site 1052684012480 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1052684012481 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1052684012482 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052684012483 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052684012484 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 1052684012485 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1052684012486 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1052684012487 Colicin V production protein; Region: Colicin_V; pfam02674 1052684012488 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1052684012489 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1052684012490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684012491 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684012492 putative substrate translocation pore; other site 1052684012493 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1052684012494 active site 1052684012495 metal binding site [ion binding]; metal-binding site 1052684012496 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 1052684012497 UbiA prenyltransferase family; Region: UbiA; pfam01040 1052684012498 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1052684012499 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052684012500 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1052684012501 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1052684012502 active site 1052684012503 HIGH motif; other site 1052684012504 dimer interface [polypeptide binding]; other site 1052684012505 KMSKS motif; other site 1052684012506 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 1052684012507 active site 1052684012508 catalytic residues [active] 1052684012509 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052684012510 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 1052684012511 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 1052684012512 active site 1052684012513 Zn binding site [ion binding]; other site 1052684012514 YycC-like protein; Region: YycC; pfam14174 1052684012515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 1052684012516 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 1052684012517 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 1052684012518 apolar tunnel; other site 1052684012519 heme binding site [chemical binding]; other site 1052684012520 dimerization interface [polypeptide binding]; other site 1052684012521 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 1052684012522 Nucleoside recognition; Region: Gate; pfam07670 1052684012523 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 1052684012524 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1052684012525 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1052684012526 lipoyl synthase; Provisional; Region: PRK05481 1052684012527 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684012528 FeS/SAM binding site; other site 1052684012529 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1052684012530 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052684012531 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 1052684012532 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052684012533 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052684012534 active site 1052684012535 catalytic tetrad [active] 1052684012536 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684012537 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684012538 dimer interface [polypeptide binding]; other site 1052684012539 conserved gate region; other site 1052684012540 putative PBP binding loops; other site 1052684012541 ABC-ATPase subunit interface; other site 1052684012542 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1052684012543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684012544 dimer interface [polypeptide binding]; other site 1052684012545 conserved gate region; other site 1052684012546 putative PBP binding loops; other site 1052684012547 ABC-ATPase subunit interface; other site 1052684012548 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684012549 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684012550 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684012551 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684012552 dimerization interface [polypeptide binding]; other site 1052684012553 Histidine kinase; Region: His_kinase; pfam06580 1052684012554 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684012555 ATP binding site [chemical binding]; other site 1052684012556 Mg2+ binding site [ion binding]; other site 1052684012557 G-X-G motif; other site 1052684012558 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684012559 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684012560 active site 1052684012561 phosphorylation site [posttranslational modification] 1052684012562 intermolecular recognition site; other site 1052684012563 dimerization interface [polypeptide binding]; other site 1052684012564 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684012565 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684012566 A new structural DNA glycosylase; Region: AlkD_like; cd06561 1052684012567 active site 1052684012568 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1052684012569 endonuclease III; Region: ENDO3c; smart00478 1052684012570 minor groove reading motif; other site 1052684012571 helix-hairpin-helix signature motif; other site 1052684012572 substrate binding pocket [chemical binding]; other site 1052684012573 active site 1052684012574 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1052684012575 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684012576 FeS/SAM binding site; other site 1052684012577 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1052684012578 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1052684012579 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1052684012580 DNA binding site [nucleotide binding] 1052684012581 active site 1052684012582 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 1052684012583 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1052684012584 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684012585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684012586 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1052684012587 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 1052684012588 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 1052684012589 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1052684012590 active site turn [active] 1052684012591 phosphorylation site [posttranslational modification] 1052684012592 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1052684012593 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1052684012594 HPr interaction site; other site 1052684012595 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1052684012596 active site 1052684012597 phosphorylation site [posttranslational modification] 1052684012598 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052684012599 CAT RNA binding domain; Region: CAT_RBD; smart01061 1052684012600 PRD domain; Region: PRD; pfam00874 1052684012601 PRD domain; Region: PRD; pfam00874 1052684012602 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1052684012603 beta-galactosidase; Region: BGL; TIGR03356 1052684012604 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 1052684012605 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052684012606 substrate binding site [chemical binding]; other site 1052684012607 trimer interface [polypeptide binding]; other site 1052684012608 Mn binding site [ion binding]; other site 1052684012609 transketolase; Reviewed; Region: PRK05899 1052684012610 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1052684012611 TPP-binding site [chemical binding]; other site 1052684012612 dimer interface [polypeptide binding]; other site 1052684012613 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1052684012614 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1052684012615 PYR/PP interface [polypeptide binding]; other site 1052684012616 dimer interface [polypeptide binding]; other site 1052684012617 TPP binding site [chemical binding]; other site 1052684012618 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1052684012619 glycerol kinase; Provisional; Region: glpK; PRK00047 1052684012620 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1052684012621 N- and C-terminal domain interface [polypeptide binding]; other site 1052684012622 active site 1052684012623 MgATP binding site [chemical binding]; other site 1052684012624 catalytic site [active] 1052684012625 metal binding site [ion binding]; metal-binding site 1052684012626 glycerol binding site [chemical binding]; other site 1052684012627 homotetramer interface [polypeptide binding]; other site 1052684012628 homodimer interface [polypeptide binding]; other site 1052684012629 FBP binding site [chemical binding]; other site 1052684012630 protein IIAGlc interface [polypeptide binding]; other site 1052684012631 HTH domain; Region: HTH_11; pfam08279 1052684012632 Mga helix-turn-helix domain; Region: Mga; pfam05043 1052684012633 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1052684012634 PRD domain; Region: PRD; pfam00874 1052684012635 PRD domain; Region: PRD; pfam00874 1052684012636 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052684012637 active site 1052684012638 P-loop; other site 1052684012639 phosphorylation site [posttranslational modification] 1052684012640 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052684012641 active site 1052684012642 phosphorylation site [posttranslational modification] 1052684012643 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1052684012644 methionine cluster; other site 1052684012645 active site 1052684012646 phosphorylation site [posttranslational modification] 1052684012647 metal binding site [ion binding]; metal-binding site 1052684012648 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1052684012649 active site 1052684012650 P-loop; other site 1052684012651 phosphorylation site [posttranslational modification] 1052684012652 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1052684012653 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052684012654 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1052684012655 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1052684012656 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684012657 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684012658 DNA binding residues [nucleotide binding] 1052684012659 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1052684012660 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052684012661 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052684012662 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052684012663 FtsX-like permease family; Region: FtsX; pfam02687 1052684012664 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052684012665 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052684012666 Walker A/P-loop; other site 1052684012667 ATP binding site [chemical binding]; other site 1052684012668 Q-loop/lid; other site 1052684012669 ABC transporter signature motif; other site 1052684012670 Walker B; other site 1052684012671 D-loop; other site 1052684012672 H-loop/switch region; other site 1052684012673 HlyD family secretion protein; Region: HlyD_2; pfam12700 1052684012674 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1052684012675 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052684012676 putative membrane fusion protein; Region: TIGR02828 1052684012677 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1052684012678 FtsX-like permease family; Region: FtsX; pfam02687 1052684012679 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052684012680 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052684012681 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052684012682 Walker A/P-loop; other site 1052684012683 ATP binding site [chemical binding]; other site 1052684012684 Q-loop/lid; other site 1052684012685 ABC transporter signature motif; other site 1052684012686 Walker B; other site 1052684012687 D-loop; other site 1052684012688 H-loop/switch region; other site 1052684012689 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684012690 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 1052684012691 dimer interface [polypeptide binding]; other site 1052684012692 phosphorylation site [posttranslational modification] 1052684012693 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684012694 ATP binding site [chemical binding]; other site 1052684012695 Mg2+ binding site [ion binding]; other site 1052684012696 G-X-G motif; other site 1052684012697 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684012698 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684012699 active site 1052684012700 phosphorylation site [posttranslational modification] 1052684012701 intermolecular recognition site; other site 1052684012702 dimerization interface [polypeptide binding]; other site 1052684012703 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684012704 DNA binding site [nucleotide binding] 1052684012705 RNA polymerase sigma factor; Provisional; Region: PRK12543 1052684012706 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684012707 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684012708 DNA binding residues [nucleotide binding] 1052684012709 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1052684012710 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1052684012711 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1052684012712 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1052684012713 TrkA-N domain; Region: TrkA_N; pfam02254 1052684012714 TrkA-C domain; Region: TrkA_C; pfam02080 1052684012715 Small, acid-soluble spore protein I; Region: SSPI; cl07940 1052684012716 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1052684012717 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1052684012718 G1 box; other site 1052684012719 putative GEF interaction site [polypeptide binding]; other site 1052684012720 GTP/Mg2+ binding site [chemical binding]; other site 1052684012721 Switch I region; other site 1052684012722 G2 box; other site 1052684012723 G3 box; other site 1052684012724 Switch II region; other site 1052684012725 G4 box; other site 1052684012726 G5 box; other site 1052684012727 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1052684012728 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1052684012729 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1052684012730 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1052684012731 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 1052684012732 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052684012733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684012734 active site 1052684012735 phosphorylation site [posttranslational modification] 1052684012736 intermolecular recognition site; other site 1052684012737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052684012738 DNA binding residues [nucleotide binding] 1052684012739 dimerization interface [polypeptide binding]; other site 1052684012740 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1052684012741 Histidine kinase; Region: HisKA_3; pfam07730 1052684012742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684012743 ATP binding site [chemical binding]; other site 1052684012744 Mg2+ binding site [ion binding]; other site 1052684012745 G-X-G motif; other site 1052684012746 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1052684012747 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1052684012748 PspC domain; Region: PspC; pfam04024 1052684012749 PspA/IM30 family; Region: PspA_IM30; pfam04012 1052684012750 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684012751 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684012752 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684012753 putative substrate translocation pore; other site 1052684012754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684012755 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684012756 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1052684012757 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1052684012758 FeS assembly protein SufB; Region: sufB; TIGR01980 1052684012759 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1052684012760 FeS assembly protein SufD; Region: sufD; TIGR01981 1052684012761 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1052684012762 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1052684012763 Walker A/P-loop; other site 1052684012764 ATP binding site [chemical binding]; other site 1052684012765 Q-loop/lid; other site 1052684012766 ABC transporter signature motif; other site 1052684012767 Walker B; other site 1052684012768 D-loop; other site 1052684012769 H-loop/switch region; other site 1052684012770 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684012771 MarR family; Region: MarR; pfam01047 1052684012772 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052684012773 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684012774 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1052684012775 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 1052684012776 active site 1052684012777 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052684012778 metal binding site 2 [ion binding]; metal-binding site 1052684012779 putative DNA binding helix; other site 1052684012780 metal binding site 1 [ion binding]; metal-binding site 1052684012781 dimer interface [polypeptide binding]; other site 1052684012782 structural Zn2+ binding site [ion binding]; other site 1052684012783 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052684012784 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052684012785 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1052684012786 MgtC family; Region: MgtC; pfam02308 1052684012787 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684012788 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684012789 Coenzyme A binding pocket [chemical binding]; other site 1052684012790 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1052684012791 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1052684012792 GatB domain; Region: GatB_Yqey; smart00845 1052684012793 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1052684012794 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1052684012795 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1052684012796 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1052684012797 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1052684012798 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1052684012799 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1052684012800 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052684012801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684012802 S-adenosylmethionine binding site [chemical binding]; other site 1052684012803 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1052684012804 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 1052684012805 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1052684012806 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 1052684012807 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 1052684012808 Pirin-related protein [General function prediction only]; Region: COG1741 1052684012809 Pirin; Region: Pirin; pfam02678 1052684012810 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 1052684012811 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1052684012812 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1052684012813 active site 1052684012814 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 1052684012815 Cl binding site [ion binding]; other site 1052684012816 oligomer interface [polypeptide binding]; other site 1052684012817 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1052684012818 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 1052684012819 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684012820 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1052684012821 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1052684012822 DNA binding residues [nucleotide binding] 1052684012823 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1052684012824 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684012825 ATP binding site [chemical binding]; other site 1052684012826 Mg2+ binding site [ion binding]; other site 1052684012827 G-X-G motif; other site 1052684012828 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1052684012829 anti sigma factor interaction site; other site 1052684012830 regulatory phosphorylation site [posttranslational modification]; other site 1052684012831 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684012832 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684012833 active site 1052684012834 phosphorylation site [posttranslational modification] 1052684012835 intermolecular recognition site; other site 1052684012836 dimerization interface [polypeptide binding]; other site 1052684012837 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684012838 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684012839 dimer interface [polypeptide binding]; other site 1052684012840 phosphorylation site [posttranslational modification] 1052684012841 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684012842 ATP binding site [chemical binding]; other site 1052684012843 Mg2+ binding site [ion binding]; other site 1052684012844 G-X-G motif; other site 1052684012845 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684012846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684012847 active site 1052684012848 phosphorylation site [posttranslational modification] 1052684012849 intermolecular recognition site; other site 1052684012850 dimerization interface [polypeptide binding]; other site 1052684012851 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 1052684012852 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1052684012853 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 1052684012854 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1052684012855 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1052684012856 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1052684012857 GAF domain; Region: GAF_3; pfam13492 1052684012858 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684012859 dimer interface [polypeptide binding]; other site 1052684012860 phosphorylation site [posttranslational modification] 1052684012861 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684012862 ATP binding site [chemical binding]; other site 1052684012863 Mg2+ binding site [ion binding]; other site 1052684012864 G-X-G motif; other site 1052684012865 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684012866 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684012867 active site 1052684012868 phosphorylation site [posttranslational modification] 1052684012869 intermolecular recognition site; other site 1052684012870 dimerization interface [polypeptide binding]; other site 1052684012871 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1052684012872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684012873 active site 1052684012874 phosphorylation site [posttranslational modification] 1052684012875 intermolecular recognition site; other site 1052684012876 dimerization interface [polypeptide binding]; other site 1052684012877 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684012878 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684012879 active site 1052684012880 phosphorylation site [posttranslational modification] 1052684012881 intermolecular recognition site; other site 1052684012882 dimerization interface [polypeptide binding]; other site 1052684012883 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684012884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684012885 active site 1052684012886 phosphorylation site [posttranslational modification] 1052684012887 intermolecular recognition site; other site 1052684012888 dimerization interface [polypeptide binding]; other site 1052684012889 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1052684012890 Heat induced stress protein YflT; Region: YflT; pfam11181 1052684012891 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 1052684012892 Bacterial SH3 domain; Region: SH3_3; pfam08239 1052684012893 Bacterial SH3 domain; Region: SH3_3; pfam08239 1052684012894 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052684012895 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052684012896 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1052684012897 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1052684012898 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1052684012899 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052684012900 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052684012901 ABC transporter; Region: ABC_tran_2; pfam12848 1052684012902 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052684012903 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052684012904 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052684012905 Walker A/P-loop; other site 1052684012906 ATP binding site [chemical binding]; other site 1052684012907 Q-loop/lid; other site 1052684012908 ABC transporter signature motif; other site 1052684012909 Walker B; other site 1052684012910 D-loop; other site 1052684012911 H-loop/switch region; other site 1052684012912 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052684012913 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684012914 dimer interface [polypeptide binding]; other site 1052684012915 ABC-ATPase subunit interface; other site 1052684012916 putative PBP binding regions; other site 1052684012917 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684012918 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052684012919 intersubunit interface [polypeptide binding]; other site 1052684012920 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 1052684012921 heme-binding site [chemical binding]; other site 1052684012922 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1052684012923 heme-binding site [chemical binding]; other site 1052684012924 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 1052684012925 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1052684012926 heme-binding site [chemical binding]; other site 1052684012927 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1052684012928 heme-binding site [chemical binding]; other site 1052684012929 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 1052684012930 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1052684012931 heme-binding site [chemical binding]; other site 1052684012932 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1052684012933 heme-binding site [chemical binding]; other site 1052684012934 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1052684012935 heme-binding site [chemical binding]; other site 1052684012936 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1052684012937 heme-binding site [chemical binding]; other site 1052684012938 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1052684012939 heme-binding site [chemical binding]; other site 1052684012940 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1052684012941 heme-binding site [chemical binding]; other site 1052684012942 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1052684012943 heme-binding site [chemical binding]; other site 1052684012944 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1052684012945 heme-binding site [chemical binding]; other site 1052684012946 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 1052684012947 heme-binding site [chemical binding]; other site 1052684012948 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1052684012949 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1052684012950 intersubunit interface [polypeptide binding]; other site 1052684012951 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052684012952 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684012953 ABC-ATPase subunit interface; other site 1052684012954 dimer interface [polypeptide binding]; other site 1052684012955 putative PBP binding regions; other site 1052684012956 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052684012957 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052684012958 Walker A/P-loop; other site 1052684012959 ATP binding site [chemical binding]; other site 1052684012960 Q-loop/lid; other site 1052684012961 ABC transporter signature motif; other site 1052684012962 Walker B; other site 1052684012963 D-loop; other site 1052684012964 H-loop/switch region; other site 1052684012965 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 1052684012966 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1052684012967 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1052684012968 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1052684012969 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1052684012970 MarR family; Region: MarR_2; cl17246 1052684012971 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052684012972 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684012973 putative substrate translocation pore; other site 1052684012974 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 1052684012975 Virulence factor; Region: Virulence_fact; pfam13769 1052684012976 HEAT repeats; Region: HEAT_2; pfam13646 1052684012977 HEAT repeats; Region: HEAT_2; pfam13646 1052684012978 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 1052684012979 lysine transporter; Provisional; Region: PRK10836 1052684012980 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052684012981 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1052684012982 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1052684012983 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1052684012984 G1 box; other site 1052684012985 GTP/Mg2+ binding site [chemical binding]; other site 1052684012986 Switch I region; other site 1052684012987 G2 box; other site 1052684012988 G3 box; other site 1052684012989 Switch II region; other site 1052684012990 G4 box; other site 1052684012991 G5 box; other site 1052684012992 Nucleoside recognition; Region: Gate; pfam07670 1052684012993 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1052684012994 Nucleoside recognition; Region: Gate; pfam07670 1052684012995 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1052684012996 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1052684012997 Walker A/P-loop; other site 1052684012998 ATP binding site [chemical binding]; other site 1052684012999 Q-loop/lid; other site 1052684013000 ABC transporter signature motif; other site 1052684013001 Walker B; other site 1052684013002 D-loop; other site 1052684013003 H-loop/switch region; other site 1052684013004 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1052684013005 Peptidase C39 family; Region: Peptidase_C39; pfam03412 1052684013006 putative active site [active] 1052684013007 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684013008 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684013009 Walker A/P-loop; other site 1052684013010 ATP binding site [chemical binding]; other site 1052684013011 Q-loop/lid; other site 1052684013012 ABC transporter signature motif; other site 1052684013013 Walker B; other site 1052684013014 D-loop; other site 1052684013015 H-loop/switch region; other site 1052684013016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052684013017 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 1052684013018 DNA binding residues [nucleotide binding] 1052684013019 dimerization interface [polypeptide binding]; other site 1052684013020 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 1052684013021 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 1052684013022 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 1052684013023 active site 1052684013024 zinc binding site [ion binding]; other site 1052684013025 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1052684013026 N- and C-terminal domain interface [polypeptide binding]; other site 1052684013027 D-xylulose kinase; Region: XylB; TIGR01312 1052684013028 active site 1052684013029 MgATP binding site [chemical binding]; other site 1052684013030 catalytic site [active] 1052684013031 metal binding site [ion binding]; metal-binding site 1052684013032 xylulose binding site [chemical binding]; other site 1052684013033 homodimer interface [polypeptide binding]; other site 1052684013034 xylose isomerase; Provisional; Region: PRK05474 1052684013035 xylose isomerase; Region: xylose_isom_A; TIGR02630 1052684013036 MarR family; Region: MarR_2; pfam12802 1052684013037 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1052684013038 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1052684013039 nucleotide binding site [chemical binding]; other site 1052684013040 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1052684013041 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1052684013042 catalytic residues [active] 1052684013043 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1052684013044 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1052684013045 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684013046 ZIP Zinc transporter; Region: Zip; pfam02535 1052684013047 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 1052684013048 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1052684013049 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052684013050 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052684013051 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1052684013052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684013053 putative substrate translocation pore; other site 1052684013054 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1052684013055 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052684013056 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1052684013057 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1052684013058 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1052684013059 metal-binding site [ion binding] 1052684013060 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1052684013061 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1052684013062 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1052684013063 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684013064 dimerization interface [polypeptide binding]; other site 1052684013065 putative DNA binding site [nucleotide binding]; other site 1052684013066 putative Zn2+ binding site [ion binding]; other site 1052684013067 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1052684013068 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 1052684013069 putative active site [active] 1052684013070 putative FMN binding site [chemical binding]; other site 1052684013071 putative substrate binding site [chemical binding]; other site 1052684013072 putative catalytic residue [active] 1052684013073 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 1052684013074 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1052684013075 Subunit I/III interface [polypeptide binding]; other site 1052684013076 Subunit III/IV interface [polypeptide binding]; other site 1052684013077 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1052684013078 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1052684013079 D-pathway; other site 1052684013080 Putative ubiquinol binding site [chemical binding]; other site 1052684013081 Low-spin heme (heme b) binding site [chemical binding]; other site 1052684013082 Putative water exit pathway; other site 1052684013083 Binuclear center (heme o3/CuB) [ion binding]; other site 1052684013084 K-pathway; other site 1052684013085 Putative proton exit pathway; other site 1052684013086 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1052684013087 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1052684013088 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1052684013089 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 1052684013090 beta-galactosidase; Region: BGL; TIGR03356 1052684013091 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684013092 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684013093 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684013094 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684013095 dimer interface [polypeptide binding]; other site 1052684013096 ABC-ATPase subunit interface; other site 1052684013097 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684013098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684013099 dimer interface [polypeptide binding]; other site 1052684013100 conserved gate region; other site 1052684013101 putative PBP binding loops; other site 1052684013102 ABC-ATPase subunit interface; other site 1052684013103 NnrS protein; Region: NnrS; cl01258 1052684013104 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 1052684013105 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1052684013106 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684013107 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1052684013108 Walker A/P-loop; other site 1052684013109 ATP binding site [chemical binding]; other site 1052684013110 Q-loop/lid; other site 1052684013111 ABC transporter signature motif; other site 1052684013112 Walker B; other site 1052684013113 D-loop; other site 1052684013114 H-loop/switch region; other site 1052684013115 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1052684013116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684013117 Walker A/P-loop; other site 1052684013118 ATP binding site [chemical binding]; other site 1052684013119 Q-loop/lid; other site 1052684013120 ABC transporter signature motif; other site 1052684013121 Walker B; other site 1052684013122 D-loop; other site 1052684013123 H-loop/switch region; other site 1052684013124 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1052684013125 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1052684013126 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1052684013127 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1052684013128 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684013129 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684013130 active site 1052684013131 phosphorylation site [posttranslational modification] 1052684013132 intermolecular recognition site; other site 1052684013133 dimerization interface [polypeptide binding]; other site 1052684013134 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684013135 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684013136 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052684013137 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684013138 dimerization interface [polypeptide binding]; other site 1052684013139 Histidine kinase; Region: His_kinase; pfam06580 1052684013140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684013141 ATP binding site [chemical binding]; other site 1052684013142 Mg2+ binding site [ion binding]; other site 1052684013143 G-X-G motif; other site 1052684013144 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1052684013145 active site 1052684013146 catalytic residues [active] 1052684013147 metal binding site [ion binding]; metal-binding site 1052684013148 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 1052684013149 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1052684013150 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1052684013151 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1052684013152 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052684013153 active site 1052684013154 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1052684013155 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1052684013156 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1052684013157 active site 1052684013158 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1052684013159 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1052684013160 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1052684013161 Domain of unknown function DUF21; Region: DUF21; pfam01595 1052684013162 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1052684013163 Transporter associated domain; Region: CorC_HlyC; pfam03471 1052684013164 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1052684013165 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052684013166 catalytic residues [active] 1052684013167 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052684013168 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052684013169 active site 1052684013170 catalytic tetrad [active] 1052684013171 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1052684013172 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 1052684013173 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 1052684013174 putative ligand binding residues [chemical binding]; other site 1052684013175 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 1052684013176 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052684013177 Walker A/P-loop; other site 1052684013178 ATP binding site [chemical binding]; other site 1052684013179 Q-loop/lid; other site 1052684013180 ABC transporter signature motif; other site 1052684013181 Walker B; other site 1052684013182 D-loop; other site 1052684013183 H-loop/switch region; other site 1052684013184 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684013185 ABC-ATPase subunit interface; other site 1052684013186 dimer interface [polypeptide binding]; other site 1052684013187 putative PBP binding regions; other site 1052684013188 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1052684013189 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1052684013190 ABC-ATPase subunit interface; other site 1052684013191 dimer interface [polypeptide binding]; other site 1052684013192 putative PBP binding regions; other site 1052684013193 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684013194 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684013195 active site 1052684013196 phosphorylation site [posttranslational modification] 1052684013197 intermolecular recognition site; other site 1052684013198 dimerization interface [polypeptide binding]; other site 1052684013199 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684013200 DNA binding site [nucleotide binding] 1052684013201 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684013202 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1052684013203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684013204 ATP binding site [chemical binding]; other site 1052684013205 Mg2+ binding site [ion binding]; other site 1052684013206 G-X-G motif; other site 1052684013207 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052684013208 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052684013209 Walker A/P-loop; other site 1052684013210 ATP binding site [chemical binding]; other site 1052684013211 Q-loop/lid; other site 1052684013212 ABC transporter signature motif; other site 1052684013213 Walker B; other site 1052684013214 D-loop; other site 1052684013215 H-loop/switch region; other site 1052684013216 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052684013217 FtsX-like permease family; Region: FtsX; pfam02687 1052684013218 FtsX-like permease family; Region: FtsX; pfam02687 1052684013219 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684013220 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684013221 dimer interface [polypeptide binding]; other site 1052684013222 phosphorylation site [posttranslational modification] 1052684013223 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052684013224 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052684013225 Walker A/P-loop; other site 1052684013226 ATP binding site [chemical binding]; other site 1052684013227 Q-loop/lid; other site 1052684013228 ABC transporter signature motif; other site 1052684013229 Walker B; other site 1052684013230 D-loop; other site 1052684013231 H-loop/switch region; other site 1052684013232 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052684013233 FtsX-like permease family; Region: FtsX; pfam02687 1052684013234 FtsX-like permease family; Region: FtsX; pfam02687 1052684013235 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684013236 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1052684013237 FeS/SAM binding site; other site 1052684013238 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1052684013239 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1052684013240 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684013241 FeS/SAM binding site; other site 1052684013242 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1052684013243 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684013244 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684013245 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 1052684013246 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1052684013247 Walker A/P-loop; other site 1052684013248 ATP binding site [chemical binding]; other site 1052684013249 Q-loop/lid; other site 1052684013250 ABC transporter signature motif; other site 1052684013251 Walker B; other site 1052684013252 D-loop; other site 1052684013253 H-loop/switch region; other site 1052684013254 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684013255 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684013256 ATP binding site [chemical binding]; other site 1052684013257 Mg2+ binding site [ion binding]; other site 1052684013258 G-X-G motif; other site 1052684013259 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1052684013260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684013261 active site 1052684013262 phosphorylation site [posttranslational modification] 1052684013263 intermolecular recognition site; other site 1052684013264 dimerization interface [polypeptide binding]; other site 1052684013265 LytTr DNA-binding domain; Region: LytTR; smart00850 1052684013266 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1052684013267 active site 1052684013268 catalytic residues [active] 1052684013269 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1052684013270 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1052684013271 catalytic residues [active] 1052684013272 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052684013273 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052684013274 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052684013275 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1052684013276 Zn binding site [ion binding]; other site 1052684013277 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1052684013278 Zn binding site [ion binding]; other site 1052684013279 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1052684013280 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1052684013281 active site 1052684013282 Zn binding site [ion binding]; other site 1052684013283 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1052684013284 dimer interface [polypeptide binding]; other site 1052684013285 substrate binding site [chemical binding]; other site 1052684013286 ATP binding site [chemical binding]; other site 1052684013287 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1052684013288 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1052684013289 active site 1052684013290 metal binding site [ion binding]; metal-binding site 1052684013291 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1052684013292 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 1052684013293 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052684013294 membrane-bound complex binding site; other site 1052684013295 hinge residues; other site 1052684013296 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 1052684013297 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1052684013298 Walker A/P-loop; other site 1052684013299 ATP binding site [chemical binding]; other site 1052684013300 Q-loop/lid; other site 1052684013301 ABC transporter signature motif; other site 1052684013302 Walker B; other site 1052684013303 D-loop; other site 1052684013304 H-loop/switch region; other site 1052684013305 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1052684013306 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684013307 dimer interface [polypeptide binding]; other site 1052684013308 conserved gate region; other site 1052684013309 ABC-ATPase subunit interface; other site 1052684013310 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1052684013311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684013312 dimer interface [polypeptide binding]; other site 1052684013313 conserved gate region; other site 1052684013314 putative PBP binding loops; other site 1052684013315 ABC-ATPase subunit interface; other site 1052684013316 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1052684013317 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052684013318 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052684013319 catalytic residue [active] 1052684013320 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684013321 dimer interface [polypeptide binding]; other site 1052684013322 conserved gate region; other site 1052684013323 putative PBP binding loops; other site 1052684013324 ABC-ATPase subunit interface; other site 1052684013325 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1052684013326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684013327 dimer interface [polypeptide binding]; other site 1052684013328 conserved gate region; other site 1052684013329 putative PBP binding loops; other site 1052684013330 ABC-ATPase subunit interface; other site 1052684013331 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 1052684013332 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1052684013333 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1052684013334 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1052684013335 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1052684013336 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1052684013337 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1052684013338 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1052684013339 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1052684013340 phosphopentomutase; Provisional; Region: PRK05362 1052684013341 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1052684013342 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1052684013343 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1052684013344 Nucleoside recognition; Region: Gate; pfam07670 1052684013345 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1052684013346 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1052684013347 active site 1052684013348 catalytic motif [active] 1052684013349 Zn binding site [ion binding]; other site 1052684013350 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1052684013351 intersubunit interface [polypeptide binding]; other site 1052684013352 active site 1052684013353 catalytic residue [active] 1052684013354 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1052684013355 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684013356 DNA binding residues [nucleotide binding] 1052684013357 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1052684013358 CheW-like domain; Region: CheW; pfam01584 1052684013359 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1052684013360 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1052684013361 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684013362 S-adenosylmethionine binding site [chemical binding]; other site 1052684013363 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1052684013364 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 1052684013365 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684013366 Interdomain contacts; other site 1052684013367 Cytokine receptor motif; other site 1052684013368 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1052684013369 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1052684013370 catalytic motif [active] 1052684013371 Zn binding site [ion binding]; other site 1052684013372 RibD C-terminal domain; Region: RibD_C; cl17279 1052684013373 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1052684013374 dimerization interface [polypeptide binding]; other site 1052684013375 active site 1052684013376 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1052684013377 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 1052684013378 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684013379 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052684013380 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684013381 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052684013382 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 1052684013383 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1052684013384 conserved cys residue [active] 1052684013385 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1052684013386 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 1052684013387 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1052684013388 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1052684013389 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1052684013390 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684013391 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052684013392 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1052684013393 arsenical pump membrane protein; Provisional; Region: PRK15445 1052684013394 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1052684013395 transmembrane helices; other site 1052684013396 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 1052684013397 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1052684013398 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1052684013399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684013400 sugar efflux transporter; Region: 2A0120; TIGR00899 1052684013401 putative substrate translocation pore; other site 1052684013402 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1052684013403 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1052684013404 active site 1052684013405 TDP-binding site; other site 1052684013406 acceptor substrate-binding pocket; other site 1052684013407 homodimer interface [polypeptide binding]; other site 1052684013408 Pectate lyase; Region: Pec_lyase_C; cl01593 1052684013409 putative pectinesterase; Region: PLN02432; cl01911 1052684013410 Pectinesterase; Region: Pectinesterase; pfam01095 1052684013411 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684013412 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1052684013413 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684013414 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684013415 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1052684013416 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052684013417 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052684013418 catalytic residue [active] 1052684013419 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684013420 MarR family; Region: MarR_2; cl17246 1052684013421 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1052684013422 Cation efflux family; Region: Cation_efflux; cl00316 1052684013423 HlyD family secretion protein; Region: HlyD_2; pfam12700 1052684013424 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1052684013425 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052684013426 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052684013427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684013428 active site 1052684013429 phosphorylation site [posttranslational modification] 1052684013430 intermolecular recognition site; other site 1052684013431 dimerization interface [polypeptide binding]; other site 1052684013432 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052684013433 DNA binding residues [nucleotide binding] 1052684013434 dimerization interface [polypeptide binding]; other site 1052684013435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052684013436 Histidine kinase; Region: HisKA_3; pfam07730 1052684013437 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684013438 ATP binding site [chemical binding]; other site 1052684013439 Mg2+ binding site [ion binding]; other site 1052684013440 G-X-G motif; other site 1052684013441 Small acid-soluble spore protein H family; Region: SspH; pfam08141 1052684013442 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 1052684013443 glycosyltransferase, MGT family; Region: MGT; TIGR01426 1052684013444 active site 1052684013445 TDP-binding site; other site 1052684013446 acceptor substrate-binding pocket; other site 1052684013447 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1052684013448 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1052684013449 substrate binding [chemical binding]; other site 1052684013450 active site 1052684013451 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1052684013452 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684013453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684013454 dimer interface [polypeptide binding]; other site 1052684013455 conserved gate region; other site 1052684013456 putative PBP binding loops; other site 1052684013457 ABC-ATPase subunit interface; other site 1052684013458 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684013459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684013460 dimer interface [polypeptide binding]; other site 1052684013461 conserved gate region; other site 1052684013462 putative PBP binding loops; other site 1052684013463 ABC-ATPase subunit interface; other site 1052684013464 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684013465 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684013466 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684013467 DNA binding site [nucleotide binding] 1052684013468 domain linker motif; other site 1052684013469 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1052684013470 dimerization interface [polypeptide binding]; other site 1052684013471 ligand binding site [chemical binding]; other site 1052684013472 sodium binding site [ion binding]; other site 1052684013473 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 1052684013474 Condensation domain; Region: Condensation; pfam00668 1052684013475 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684013476 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1052684013477 acyl-activating enzyme (AAE) consensus motif; other site 1052684013478 AMP binding site [chemical binding]; other site 1052684013479 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684013480 peptide synthase; Provisional; Region: PRK12467 1052684013481 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684013482 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684013483 acyl-activating enzyme (AAE) consensus motif; other site 1052684013484 AMP binding site [chemical binding]; other site 1052684013485 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684013486 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684013487 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052684013488 acyl-activating enzyme (AAE) consensus motif; other site 1052684013489 AMP binding site [chemical binding]; other site 1052684013490 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684013491 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684013492 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052684013493 acyl-activating enzyme (AAE) consensus motif; other site 1052684013494 AMP binding site [chemical binding]; other site 1052684013495 active site 1052684013496 CoA binding site [chemical binding]; other site 1052684013497 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684013498 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684013499 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684013500 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052684013501 acyl-activating enzyme (AAE) consensus motif; other site 1052684013502 AMP binding site [chemical binding]; other site 1052684013503 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684013504 Condensation domain; Region: Condensation; pfam00668 1052684013505 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684013506 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684013507 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684013508 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684013509 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1052684013510 Walker A/P-loop; other site 1052684013511 ATP binding site [chemical binding]; other site 1052684013512 Q-loop/lid; other site 1052684013513 ABC transporter signature motif; other site 1052684013514 Walker B; other site 1052684013515 D-loop; other site 1052684013516 H-loop/switch region; other site 1052684013517 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1052684013518 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1052684013519 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1052684013520 Walker A/P-loop; other site 1052684013521 ATP binding site [chemical binding]; other site 1052684013522 Q-loop/lid; other site 1052684013523 ABC transporter signature motif; other site 1052684013524 Walker B; other site 1052684013525 D-loop; other site 1052684013526 H-loop/switch region; other site 1052684013527 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684013528 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1052684013529 acyl-activating enzyme (AAE) consensus motif; other site 1052684013530 AMP binding site [chemical binding]; other site 1052684013531 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684013532 Thioesterase domain; Region: Thioesterase; pfam00975 1052684013533 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684013534 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 1052684013535 acyl-activating enzyme (AAE) consensus motif; other site 1052684013536 AMP binding site [chemical binding]; other site 1052684013537 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684013538 Condensation domain; Region: Condensation; pfam00668 1052684013539 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684013540 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 1052684013541 Condensation domain; Region: Condensation; pfam00668 1052684013542 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684013543 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684013544 acyl-activating enzyme (AAE) consensus motif; other site 1052684013545 AMP binding site [chemical binding]; other site 1052684013546 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684013547 Condensation domain; Region: Condensation; pfam00668 1052684013548 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684013549 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684013550 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052684013551 acyl-activating enzyme (AAE) consensus motif; other site 1052684013552 AMP binding site [chemical binding]; other site 1052684013553 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684013554 Condensation domain; Region: Condensation; pfam00668 1052684013555 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684013556 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684013557 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 1052684013558 acyl-activating enzyme (AAE) consensus motif; other site 1052684013559 AMP binding site [chemical binding]; other site 1052684013560 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684013561 Condensation domain; Region: Condensation; pfam00668 1052684013562 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684013563 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684013564 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1052684013565 Erythromycin esterase; Region: Erythro_esteras; pfam05139 1052684013566 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052684013567 Beta-lactamase; Region: Beta-lactamase; pfam00144 1052684013568 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1052684013569 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1052684013570 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1052684013571 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1052684013572 glutaminase active site [active] 1052684013573 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1052684013574 dimer interface [polypeptide binding]; other site 1052684013575 active site 1052684013576 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1052684013577 dimer interface [polypeptide binding]; other site 1052684013578 active site 1052684013579 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1052684013580 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1052684013581 active site 1052684013582 substrate binding site [chemical binding]; other site 1052684013583 metal binding site [ion binding]; metal-binding site 1052684013584 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1052684013585 YbbR-like protein; Region: YbbR; pfam07949 1052684013586 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1052684013587 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1052684013588 Putative zinc-finger; Region: zf-HC2; pfam13490 1052684013589 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 1052684013590 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1052684013591 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1052684013592 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684013593 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684013594 DNA binding residues [nucleotide binding] 1052684013595 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1052684013596 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 1052684013597 Integral membrane protein DUF95; Region: DUF95; pfam01944 1052684013598 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052684013599 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1052684013600 Domain of unknown function DUF59; Region: DUF59; pfam01883 1052684013601 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 1052684013602 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1052684013603 Walker A motif; other site 1052684013604 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 1052684013605 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1052684013606 active site 1052684013607 metal binding site [ion binding]; metal-binding site 1052684013608 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 1052684013609 ATP-sulfurylase; Region: ATPS; cd00517 1052684013610 active site 1052684013611 HXXH motif; other site 1052684013612 flexible loop; other site 1052684013613 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1052684013614 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1052684013615 Active Sites [active] 1052684013616 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1052684013617 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1052684013618 23S rRNA interface [nucleotide binding]; other site 1052684013619 L3 interface [polypeptide binding]; other site 1052684013620 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1052684013621 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1052684013622 dimerization interface 3.5A [polypeptide binding]; other site 1052684013623 active site 1052684013624 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1052684013625 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1052684013626 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1052684013627 alphaNTD - beta interaction site [polypeptide binding]; other site 1052684013628 alphaNTD homodimer interface [polypeptide binding]; other site 1052684013629 alphaNTD - beta' interaction site [polypeptide binding]; other site 1052684013630 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1052684013631 30S ribosomal protein S11; Validated; Region: PRK05309 1052684013632 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1052684013633 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1052684013634 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1052684013635 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1052684013636 rRNA binding site [nucleotide binding]; other site 1052684013637 predicted 30S ribosome binding site; other site 1052684013638 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 1052684013639 RNA binding site [nucleotide binding]; other site 1052684013640 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1052684013641 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1052684013642 adenylate kinase; Reviewed; Region: adk; PRK00279 1052684013643 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1052684013644 AMP-binding site [chemical binding]; other site 1052684013645 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1052684013646 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1052684013647 SecY translocase; Region: SecY; pfam00344 1052684013648 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1052684013649 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1052684013650 23S rRNA binding site [nucleotide binding]; other site 1052684013651 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1052684013652 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1052684013653 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1052684013654 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1052684013655 5S rRNA interface [nucleotide binding]; other site 1052684013656 L27 interface [polypeptide binding]; other site 1052684013657 23S rRNA interface [nucleotide binding]; other site 1052684013658 L5 interface [polypeptide binding]; other site 1052684013659 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1052684013660 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1052684013661 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1052684013662 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1052684013663 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1052684013664 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1052684013665 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1052684013666 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1052684013667 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1052684013668 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1052684013669 RNA binding site [nucleotide binding]; other site 1052684013670 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1052684013671 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1052684013672 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1052684013673 23S rRNA interface [nucleotide binding]; other site 1052684013674 putative translocon interaction site; other site 1052684013675 signal recognition particle (SRP54) interaction site; other site 1052684013676 L23 interface [polypeptide binding]; other site 1052684013677 trigger factor interaction site; other site 1052684013678 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1052684013679 23S rRNA interface [nucleotide binding]; other site 1052684013680 5S rRNA interface [nucleotide binding]; other site 1052684013681 putative antibiotic binding site [chemical binding]; other site 1052684013682 L25 interface [polypeptide binding]; other site 1052684013683 L27 interface [polypeptide binding]; other site 1052684013684 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1052684013685 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1052684013686 G-X-X-G motif; other site 1052684013687 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1052684013688 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1052684013689 putative translocon binding site; other site 1052684013690 protein-rRNA interface [nucleotide binding]; other site 1052684013691 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1052684013692 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1052684013693 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1052684013694 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1052684013695 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1052684013696 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1052684013697 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1052684013698 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1052684013699 elongation factor Tu; Reviewed; Region: PRK00049 1052684013700 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1052684013701 G1 box; other site 1052684013702 GEF interaction site [polypeptide binding]; other site 1052684013703 GTP/Mg2+ binding site [chemical binding]; other site 1052684013704 Switch I region; other site 1052684013705 G2 box; other site 1052684013706 G3 box; other site 1052684013707 Switch II region; other site 1052684013708 G4 box; other site 1052684013709 G5 box; other site 1052684013710 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1052684013711 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1052684013712 Antibiotic Binding Site [chemical binding]; other site 1052684013713 elongation factor G; Reviewed; Region: PRK00007 1052684013714 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1052684013715 G1 box; other site 1052684013716 putative GEF interaction site [polypeptide binding]; other site 1052684013717 GTP/Mg2+ binding site [chemical binding]; other site 1052684013718 Switch I region; other site 1052684013719 G2 box; other site 1052684013720 G3 box; other site 1052684013721 Switch II region; other site 1052684013722 G4 box; other site 1052684013723 G5 box; other site 1052684013724 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1052684013725 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1052684013726 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1052684013727 30S ribosomal protein S7; Validated; Region: PRK05302 1052684013728 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1052684013729 S17 interaction site [polypeptide binding]; other site 1052684013730 S8 interaction site; other site 1052684013731 16S rRNA interaction site [nucleotide binding]; other site 1052684013732 streptomycin interaction site [chemical binding]; other site 1052684013733 23S rRNA interaction site [nucleotide binding]; other site 1052684013734 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1052684013735 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 1052684013736 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1052684013737 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1052684013738 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1052684013739 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1052684013740 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1052684013741 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1052684013742 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1052684013743 G-loop; other site 1052684013744 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1052684013745 DNA binding site [nucleotide binding] 1052684013746 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1052684013747 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1052684013748 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1052684013749 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1052684013750 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1052684013751 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1052684013752 RPB10 interaction site [polypeptide binding]; other site 1052684013753 RPB1 interaction site [polypeptide binding]; other site 1052684013754 RPB11 interaction site [polypeptide binding]; other site 1052684013755 RPB3 interaction site [polypeptide binding]; other site 1052684013756 RPB12 interaction site [polypeptide binding]; other site 1052684013757 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052684013758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684013759 S-adenosylmethionine binding site [chemical binding]; other site 1052684013760 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1052684013761 core dimer interface [polypeptide binding]; other site 1052684013762 peripheral dimer interface [polypeptide binding]; other site 1052684013763 L10 interface [polypeptide binding]; other site 1052684013764 L11 interface [polypeptide binding]; other site 1052684013765 putative EF-Tu interaction site [polypeptide binding]; other site 1052684013766 putative EF-G interaction site [polypeptide binding]; other site 1052684013767 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1052684013768 23S rRNA interface [nucleotide binding]; other site 1052684013769 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1052684013770 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1052684013771 mRNA/rRNA interface [nucleotide binding]; other site 1052684013772 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1052684013773 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1052684013774 23S rRNA interface [nucleotide binding]; other site 1052684013775 L7/L12 interface [polypeptide binding]; other site 1052684013776 putative thiostrepton binding site; other site 1052684013777 L25 interface [polypeptide binding]; other site 1052684013778 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1052684013779 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1052684013780 putative homodimer interface [polypeptide binding]; other site 1052684013781 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1052684013782 heterodimer interface [polypeptide binding]; other site 1052684013783 homodimer interface [polypeptide binding]; other site 1052684013784 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1052684013785 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1052684013786 RNA polymerase factor sigma-70; Validated; Region: PRK08295 1052684013787 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684013788 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1052684013789 YacP-like NYN domain; Region: NYN_YacP; pfam05991 1052684013790 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1052684013791 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1052684013792 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1052684013793 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1052684013794 active site 1052684013795 metal binding site [ion binding]; metal-binding site 1052684013796 dimerization interface [polypeptide binding]; other site 1052684013797 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1052684013798 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1052684013799 active site 1052684013800 HIGH motif; other site 1052684013801 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1052684013802 KMSKS motif; other site 1052684013803 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1052684013804 tRNA binding surface [nucleotide binding]; other site 1052684013805 anticodon binding site; other site 1052684013806 serine O-acetyltransferase; Region: cysE; TIGR01172 1052684013807 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1052684013808 trimer interface [polypeptide binding]; other site 1052684013809 active site 1052684013810 substrate binding site [chemical binding]; other site 1052684013811 CoA binding site [chemical binding]; other site 1052684013812 Protein of unknown function (DUF904); Region: DUF904; pfam06005 1052684013813 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1052684013814 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1052684013815 HIGH motif; other site 1052684013816 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1052684013817 active site 1052684013818 KMSKS motif; other site 1052684013819 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1052684013820 homotrimer interaction site [polypeptide binding]; other site 1052684013821 zinc binding site [ion binding]; other site 1052684013822 CDP-binding sites; other site 1052684013823 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1052684013824 substrate binding site; other site 1052684013825 dimer interface; other site 1052684013826 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 1052684013827 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1052684013828 putative active site [active] 1052684013829 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1052684013830 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1052684013831 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 1052684013832 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1052684013833 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 1052684013834 DNA repair protein RadA; Provisional; Region: PRK11823 1052684013835 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1052684013836 Walker A motif/ATP binding site; other site 1052684013837 ATP binding site [chemical binding]; other site 1052684013838 Walker B motif; other site 1052684013839 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1052684013840 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1052684013841 Clp amino terminal domain; Region: Clp_N; pfam02861 1052684013842 Clp amino terminal domain; Region: Clp_N; pfam02861 1052684013843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684013844 Walker A motif; other site 1052684013845 ATP binding site [chemical binding]; other site 1052684013846 Walker B motif; other site 1052684013847 arginine finger; other site 1052684013848 UvrB/uvrC motif; Region: UVR; pfam02151 1052684013849 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684013850 Walker A motif; other site 1052684013851 ATP binding site [chemical binding]; other site 1052684013852 Walker B motif; other site 1052684013853 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1052684013854 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1052684013855 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1052684013856 ADP binding site [chemical binding]; other site 1052684013857 phosphagen binding site; other site 1052684013858 substrate specificity loop; other site 1052684013859 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1052684013860 UvrB/uvrC motif; Region: UVR; pfam02151 1052684013861 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1052684013862 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 1052684013863 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 1052684013864 Coenzyme A binding pocket [chemical binding]; other site 1052684013865 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1052684013866 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1052684013867 nucleotide binding pocket [chemical binding]; other site 1052684013868 K-X-D-G motif; other site 1052684013869 catalytic site [active] 1052684013870 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1052684013871 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1052684013872 Dimer interface [polypeptide binding]; other site 1052684013873 BRCT sequence motif; other site 1052684013874 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1052684013875 Part of AAA domain; Region: AAA_19; pfam13245 1052684013876 Family description; Region: UvrD_C_2; pfam13538 1052684013877 PcrB family; Region: PcrB; pfam01884 1052684013878 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 1052684013879 substrate binding site [chemical binding]; other site 1052684013880 putative active site [active] 1052684013881 dimer interface [polypeptide binding]; other site 1052684013882 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1052684013883 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar1; cd08583 1052684013884 putative active site [active] 1052684013885 catalytic site [active] 1052684013886 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 1052684013887 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1052684013888 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1052684013889 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1052684013890 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1052684013891 Probable Catalytic site; other site 1052684013892 metal-binding site 1052684013893 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052684013894 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1052684013895 Probable Catalytic site; other site 1052684013896 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1052684013897 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1052684013898 NADP binding site [chemical binding]; other site 1052684013899 active site 1052684013900 putative substrate binding site [chemical binding]; other site 1052684013901 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1052684013902 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1052684013903 NAD binding site [chemical binding]; other site 1052684013904 substrate binding site [chemical binding]; other site 1052684013905 homodimer interface [polypeptide binding]; other site 1052684013906 active site 1052684013907 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1052684013908 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1052684013909 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1052684013910 substrate binding site; other site 1052684013911 tetramer interface; other site 1052684013912 Uncharacterized conserved protein (DUF2304); Region: DUF2304; pfam10066 1052684013913 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1052684013914 Ligand binding site; other site 1052684013915 Putative Catalytic site; other site 1052684013916 DXD motif; other site 1052684013917 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1052684013918 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 1052684013919 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1052684013920 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684013921 NAD(P) binding site [chemical binding]; other site 1052684013922 active site 1052684013923 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052684013924 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1052684013925 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052684013926 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1052684013927 active site 1052684013928 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1052684013929 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1052684013930 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1052684013931 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1052684013932 Walker A/P-loop; other site 1052684013933 ATP binding site [chemical binding]; other site 1052684013934 Q-loop/lid; other site 1052684013935 ABC transporter signature motif; other site 1052684013936 Walker B; other site 1052684013937 D-loop; other site 1052684013938 H-loop/switch region; other site 1052684013939 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 1052684013940 putative carbohydrate binding site [chemical binding]; other site 1052684013941 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1052684013942 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1052684013943 O-Antigen ligase; Region: Wzy_C; pfam04932 1052684013944 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 1052684013945 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1052684013946 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1052684013947 active site 1052684013948 tetramer interface; other site 1052684013949 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1052684013950 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1052684013951 Peptidase family U32; Region: Peptidase_U32; pfam01136 1052684013952 Collagenase; Region: DUF3656; pfam12392 1052684013953 Peptidase family U32; Region: Peptidase_U32; cl03113 1052684013954 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684013955 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052684013956 Coenzyme A binding pocket [chemical binding]; other site 1052684013957 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684013958 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684013959 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1052684013960 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1052684013961 PDZ domain; Region: PDZ_2; pfam13180 1052684013962 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 1052684013963 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052684013964 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1052684013965 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1052684013966 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1052684013967 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1052684013968 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1052684013969 excinuclease ABC subunit B; Provisional; Region: PRK05298 1052684013970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052684013971 ATP binding site [chemical binding]; other site 1052684013972 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684013973 nucleotide binding region [chemical binding]; other site 1052684013974 ATP-binding site [chemical binding]; other site 1052684013975 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1052684013976 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1052684013977 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1052684013978 flagellar motor protein MotS; Reviewed; Region: PRK06925 1052684013979 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1052684013980 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1052684013981 ligand binding site [chemical binding]; other site 1052684013982 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052684013983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684013984 sequence-specific DNA binding site [nucleotide binding]; other site 1052684013985 salt bridge; other site 1052684013986 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 1052684013987 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1052684013988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684013989 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684013990 DNA binding residues [nucleotide binding] 1052684013991 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1052684013992 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 1052684013993 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684013994 Interdomain contacts; other site 1052684013995 Cytokine receptor motif; other site 1052684013996 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1052684013997 putative metal binding site [ion binding]; other site 1052684013998 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1052684013999 Cellulose binding domain; Region: CBM_3; pfam00942 1052684014000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684014001 S-adenosylmethionine binding site [chemical binding]; other site 1052684014002 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052684014003 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1052684014004 C-terminal peptidase (prc); Region: prc; TIGR00225 1052684014005 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1052684014006 protein binding site [polypeptide binding]; other site 1052684014007 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1052684014008 Catalytic dyad [active] 1052684014009 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1052684014010 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1052684014011 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1052684014012 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052684014013 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1052684014014 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1052684014015 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1052684014016 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 1052684014017 Walker A/P-loop; other site 1052684014018 ATP binding site [chemical binding]; other site 1052684014019 Q-loop/lid; other site 1052684014020 ABC transporter signature motif; other site 1052684014021 Walker B; other site 1052684014022 D-loop; other site 1052684014023 H-loop/switch region; other site 1052684014024 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 1052684014025 VanW like protein; Region: VanW; pfam04294 1052684014026 G5 domain; Region: G5; pfam07501 1052684014027 S-layer homology domain; Region: SLH; pfam00395 1052684014028 S-layer homology domain; Region: SLH; pfam00395 1052684014029 S-formylglutathione hydrolase; Region: PLN02442 1052684014030 Putative esterase; Region: Esterase; pfam00756 1052684014031 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1052684014032 Predicted membrane protein [Function unknown]; Region: COG2246 1052684014033 GtrA-like protein; Region: GtrA; pfam04138 1052684014034 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1052684014035 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1052684014036 Ligand binding site; other site 1052684014037 Putative Catalytic site; other site 1052684014038 DXD motif; other site 1052684014039 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1052684014040 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1052684014041 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 1052684014042 DXD motif; other site 1052684014043 argininosuccinate lyase; Provisional; Region: PRK00855 1052684014044 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1052684014045 active sites [active] 1052684014046 tetramer interface [polypeptide binding]; other site 1052684014047 argininosuccinate synthase; Provisional; Region: PRK13820 1052684014048 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1052684014049 ANP binding site [chemical binding]; other site 1052684014050 Substrate Binding Site II [chemical binding]; other site 1052684014051 Substrate Binding Site I [chemical binding]; other site 1052684014052 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1052684014053 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1052684014054 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1052684014055 acetylornithine aminotransferase; Provisional; Region: PRK02627 1052684014056 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1052684014057 inhibitor-cofactor binding pocket; inhibition site 1052684014058 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1052684014059 catalytic residue [active] 1052684014060 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 1052684014061 nucleotide binding site [chemical binding]; other site 1052684014062 N-acetyl-L-glutamate binding site [chemical binding]; other site 1052684014063 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1052684014064 heterotetramer interface [polypeptide binding]; other site 1052684014065 active site pocket [active] 1052684014066 cleavage site 1052684014067 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1052684014068 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1052684014069 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1052684014070 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1052684014071 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052684014072 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1052684014073 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052684014074 peptide chain release factor 2; Provisional; Region: PRK06746 1052684014075 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1052684014076 RF-1 domain; Region: RF-1; pfam00472 1052684014077 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1052684014078 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1052684014079 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684014080 nucleotide binding region [chemical binding]; other site 1052684014081 ATP-binding site [chemical binding]; other site 1052684014082 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1052684014083 30S subunit binding site; other site 1052684014084 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1052684014085 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1052684014086 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1052684014087 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1052684014088 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1052684014089 Domain of unknown function DUF11; Region: DUF11; cl17728 1052684014090 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1052684014091 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1052684014092 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1052684014093 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1052684014094 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1052684014095 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1052684014096 Domain of unknown function DUF11; Region: DUF11; cl17728 1052684014097 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1052684014098 conserved repeat domain; Region: B_ant_repeat; TIGR01451 1052684014099 Domain of unknown function DUF11; Region: DUF11; cl17728 1052684014100 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1052684014101 DNA-binding site [nucleotide binding]; DNA binding site 1052684014102 RNA-binding motif; other site 1052684014103 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 1052684014104 flagellar capping protein; Validated; Region: fliD; PRK07737 1052684014105 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1052684014106 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1052684014107 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1052684014108 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684014109 S-adenosylmethionine binding site [chemical binding]; other site 1052684014110 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 1052684014111 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1052684014112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684014113 NAD(P) binding site [chemical binding]; other site 1052684014114 active site 1052684014115 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 1052684014116 Cephalosporin hydroxylase; Region: CmcI; pfam04989 1052684014117 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 1052684014118 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 1052684014119 NAD binding site [chemical binding]; other site 1052684014120 homotetramer interface [polypeptide binding]; other site 1052684014121 homodimer interface [polypeptide binding]; other site 1052684014122 substrate binding site [chemical binding]; other site 1052684014123 active site 1052684014124 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1052684014125 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 1052684014126 substrate binding site; other site 1052684014127 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052684014128 binding surface 1052684014129 TPR motif; other site 1052684014130 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1052684014131 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052684014132 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1052684014133 active site 1052684014134 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1052684014135 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1052684014136 putative metal binding site; other site 1052684014137 TPR repeat; Region: TPR_11; pfam13414 1052684014138 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052684014139 binding surface 1052684014140 TPR motif; other site 1052684014141 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1052684014142 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052684014143 binding surface 1052684014144 TPR motif; other site 1052684014145 flagellin; Provisional; Region: PRK12804 1052684014146 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1052684014147 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1052684014148 carbon storage regulator; Provisional; Region: PRK01712 1052684014149 flagellar assembly protein FliW; Provisional; Region: PRK13285 1052684014150 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 1052684014151 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1052684014152 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1052684014153 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 1052684014154 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1052684014155 FlgN protein; Region: FlgN; pfam05130 1052684014156 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1052684014157 flagellar operon protein TIGR03826; Region: YvyF 1052684014158 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1052684014159 non-specific DNA binding site [nucleotide binding]; other site 1052684014160 salt bridge; other site 1052684014161 sequence-specific DNA binding site [nucleotide binding]; other site 1052684014162 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052684014163 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1052684014164 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052684014165 active site 1052684014166 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1052684014167 ATP binding site [chemical binding]; other site 1052684014168 putative Mg++ binding site [ion binding]; other site 1052684014169 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684014170 nucleotide binding region [chemical binding]; other site 1052684014171 ATP-binding site [chemical binding]; other site 1052684014172 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1052684014173 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684014174 active site 1052684014175 phosphorylation site [posttranslational modification] 1052684014176 intermolecular recognition site; other site 1052684014177 dimerization interface [polypeptide binding]; other site 1052684014178 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052684014179 DNA binding residues [nucleotide binding] 1052684014180 dimerization interface [polypeptide binding]; other site 1052684014181 Sensor protein DegS; Region: DegS; pfam05384 1052684014182 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1052684014183 Histidine kinase; Region: HisKA_3; pfam07730 1052684014184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684014185 ATP binding site [chemical binding]; other site 1052684014186 Mg2+ binding site [ion binding]; other site 1052684014187 G-X-G motif; other site 1052684014188 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1052684014189 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1052684014190 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684014191 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1052684014192 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1052684014193 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052684014194 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1052684014195 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684014196 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684014197 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1052684014198 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1052684014199 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1052684014200 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1052684014201 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 1052684014202 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684014203 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 1052684014204 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684014205 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1052684014206 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1052684014207 HlyD family secretion protein; Region: HlyD_3; pfam13437 1052684014208 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1052684014209 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 1052684014210 S-layer homology domain; Region: SLH; pfam00395 1052684014211 S-layer homology domain; Region: SLH; pfam00395 1052684014212 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1052684014213 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1052684014214 Mg++ binding site [ion binding]; other site 1052684014215 putative catalytic motif [active] 1052684014216 substrate binding site [chemical binding]; other site 1052684014217 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1052684014218 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1052684014219 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1052684014220 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 1052684014221 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 1052684014222 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1052684014223 active site 1052684014224 substrate binding site [chemical binding]; other site 1052684014225 metal binding site [ion binding]; metal-binding site 1052684014226 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1052684014227 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 1052684014228 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1052684014229 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1052684014230 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1052684014231 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1052684014232 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1052684014233 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1052684014234 rod shape-determining protein Mbl; Provisional; Region: PRK13928 1052684014235 MreB and similar proteins; Region: MreB_like; cd10225 1052684014236 nucleotide binding site [chemical binding]; other site 1052684014237 Mg binding site [ion binding]; other site 1052684014238 putative protofilament interaction site [polypeptide binding]; other site 1052684014239 RodZ interaction site [polypeptide binding]; other site 1052684014240 Stage III sporulation protein D; Region: SpoIIID; pfam12116 1052684014241 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1052684014242 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052684014243 Stage II sporulation protein; Region: SpoIID; pfam08486 1052684014244 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1052684014245 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1052684014246 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1052684014247 hinge; other site 1052684014248 active site 1052684014249 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1052684014250 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1052684014251 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1052684014252 gamma subunit interface [polypeptide binding]; other site 1052684014253 epsilon subunit interface [polypeptide binding]; other site 1052684014254 LBP interface [polypeptide binding]; other site 1052684014255 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1052684014256 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1052684014257 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1052684014258 alpha subunit interaction interface [polypeptide binding]; other site 1052684014259 Walker A motif; other site 1052684014260 ATP binding site [chemical binding]; other site 1052684014261 Walker B motif; other site 1052684014262 inhibitor binding site; inhibition site 1052684014263 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1052684014264 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1052684014265 core domain interface [polypeptide binding]; other site 1052684014266 delta subunit interface [polypeptide binding]; other site 1052684014267 epsilon subunit interface [polypeptide binding]; other site 1052684014268 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1052684014269 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1052684014270 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1052684014271 beta subunit interaction interface [polypeptide binding]; other site 1052684014272 Walker A motif; other site 1052684014273 ATP binding site [chemical binding]; other site 1052684014274 Walker B motif; other site 1052684014275 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1052684014276 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1052684014277 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1052684014278 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1052684014279 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1052684014280 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1052684014281 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1052684014282 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1052684014283 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 1052684014284 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1052684014285 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1052684014286 active site 1052684014287 homodimer interface [polypeptide binding]; other site 1052684014288 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052684014289 active site 1052684014290 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684014291 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684014292 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684014293 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684014294 dimer interface [polypeptide binding]; other site 1052684014295 conserved gate region; other site 1052684014296 putative PBP binding loops; other site 1052684014297 ABC-ATPase subunit interface; other site 1052684014298 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1052684014299 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684014300 dimer interface [polypeptide binding]; other site 1052684014301 conserved gate region; other site 1052684014302 putative PBP binding loops; other site 1052684014303 ABC-ATPase subunit interface; other site 1052684014304 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1052684014305 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1052684014306 dimer interface [polypeptide binding]; other site 1052684014307 active site 1052684014308 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1052684014309 folate binding site [chemical binding]; other site 1052684014310 hypothetical protein; Provisional; Region: PRK13690 1052684014311 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1052684014312 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1052684014313 active site 1052684014314 Predicted membrane protein [Function unknown]; Region: COG1971 1052684014315 Domain of unknown function DUF; Region: DUF204; pfam02659 1052684014316 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1052684014317 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1052684014318 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 1052684014319 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1052684014320 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1052684014321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1052684014322 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1052684014323 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1052684014324 RF-1 domain; Region: RF-1; pfam00472 1052684014325 GTP-binding protein YchF; Reviewed; Region: PRK09601 1052684014326 YchF GTPase; Region: YchF; cd01900 1052684014327 G1 box; other site 1052684014328 GTP/Mg2+ binding site [chemical binding]; other site 1052684014329 Switch I region; other site 1052684014330 G2 box; other site 1052684014331 Switch II region; other site 1052684014332 G3 box; other site 1052684014333 G4 box; other site 1052684014334 G5 box; other site 1052684014335 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1052684014336 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684014337 Coenzyme A binding pocket [chemical binding]; other site 1052684014338 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1052684014339 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1052684014340 homotetramer interface [polypeptide binding]; other site 1052684014341 FMN binding site [chemical binding]; other site 1052684014342 homodimer contacts [polypeptide binding]; other site 1052684014343 putative active site [active] 1052684014344 putative substrate binding site [chemical binding]; other site 1052684014345 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1052684014346 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1052684014347 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1052684014348 ligand binding site [chemical binding]; other site 1052684014349 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 1052684014350 Protein of unknown function, DUF606; Region: DUF606; pfam04657 1052684014351 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 1052684014352 putative active site [active] 1052684014353 putative catalytic site [active] 1052684014354 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 1052684014355 PLD-like domain; Region: PLDc_2; pfam13091 1052684014356 putative active site [active] 1052684014357 putative catalytic site [active] 1052684014358 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1052684014359 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1052684014360 putative active site [active] 1052684014361 catalytic site [active] 1052684014362 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 1052684014363 putative active site [active] 1052684014364 catalytic site [active] 1052684014365 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684014366 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684014367 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1052684014368 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1052684014369 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1052684014370 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1052684014371 putative substrate binding site [chemical binding]; other site 1052684014372 putative ATP binding site [chemical binding]; other site 1052684014373 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1052684014374 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684014375 putative DNA binding site [nucleotide binding]; other site 1052684014376 putative Zn2+ binding site [ion binding]; other site 1052684014377 AsnC family; Region: AsnC_trans_reg; pfam01037 1052684014378 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1052684014379 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1052684014380 active site 1052684014381 metal binding site [ion binding]; metal-binding site 1052684014382 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1052684014383 Lysine efflux permease [General function prediction only]; Region: COG1279 1052684014384 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1052684014385 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1052684014386 GTP binding site; other site 1052684014387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684014388 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1052684014389 putative substrate translocation pore; other site 1052684014390 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1052684014391 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1052684014392 active site 1052684014393 HIGH motif; other site 1052684014394 nucleotide binding site [chemical binding]; other site 1052684014395 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1052684014396 KMSKS motif; other site 1052684014397 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1052684014398 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052684014399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1052684014400 putative acetyltransferase; Provisional; Region: PRK03624 1052684014401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684014402 Coenzyme A binding pocket [chemical binding]; other site 1052684014403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684014404 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1052684014405 putative substrate translocation pore; other site 1052684014406 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 1052684014407 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 1052684014408 putative [4Fe-4S] binding site [ion binding]; other site 1052684014409 putative molybdopterin cofactor binding site [chemical binding]; other site 1052684014410 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 1052684014411 putative molybdopterin cofactor binding site; other site 1052684014412 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1052684014413 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1052684014414 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684014415 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1052684014416 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1052684014417 catalytic residues [active] 1052684014418 dimer interface [polypeptide binding]; other site 1052684014419 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1052684014420 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1052684014421 Walker A/P-loop; other site 1052684014422 ATP binding site [chemical binding]; other site 1052684014423 Q-loop/lid; other site 1052684014424 ABC transporter signature motif; other site 1052684014425 Walker B; other site 1052684014426 D-loop; other site 1052684014427 H-loop/switch region; other site 1052684014428 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 1052684014429 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1052684014430 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1052684014431 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1052684014432 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1052684014433 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1052684014434 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 1052684014435 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052684014436 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1052684014437 ATP binding site [chemical binding]; other site 1052684014438 Mg++ binding site [ion binding]; other site 1052684014439 motif III; other site 1052684014440 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684014441 nucleotide binding region [chemical binding]; other site 1052684014442 ATP-binding site [chemical binding]; other site 1052684014443 HEAT repeats; Region: HEAT_2; pfam13646 1052684014444 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1052684014445 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1052684014446 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684014447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684014448 WHG domain; Region: WHG; pfam13305 1052684014449 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1052684014450 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1052684014451 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1052684014452 Predicted peptidase [General function prediction only]; Region: COG4099 1052684014453 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052684014454 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1052684014455 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052684014456 substrate binding pocket [chemical binding]; other site 1052684014457 membrane-bound complex binding site; other site 1052684014458 hinge residues; other site 1052684014459 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052684014460 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052684014461 Walker A/P-loop; other site 1052684014462 ATP binding site [chemical binding]; other site 1052684014463 Q-loop/lid; other site 1052684014464 ABC transporter signature motif; other site 1052684014465 Walker B; other site 1052684014466 D-loop; other site 1052684014467 H-loop/switch region; other site 1052684014468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684014469 dimer interface [polypeptide binding]; other site 1052684014470 conserved gate region; other site 1052684014471 ABC-ATPase subunit interface; other site 1052684014472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684014473 dimer interface [polypeptide binding]; other site 1052684014474 conserved gate region; other site 1052684014475 putative PBP binding loops; other site 1052684014476 ABC-ATPase subunit interface; other site 1052684014477 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1052684014478 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1052684014479 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1052684014480 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1052684014481 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1052684014482 ABC1 family; Region: ABC1; pfam03109 1052684014483 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1052684014484 active site 1052684014485 ATP binding site [chemical binding]; other site 1052684014486 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1052684014487 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1052684014488 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1052684014489 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 1052684014490 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 1052684014491 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1052684014492 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 1052684014493 catalytic triad [active] 1052684014494 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 1052684014495 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 1052684014496 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 1052684014497 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 1052684014498 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 1052684014499 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 1052684014500 active site 1052684014501 SAM binding site [chemical binding]; other site 1052684014502 homodimer interface [polypeptide binding]; other site 1052684014503 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 1052684014504 active site 1052684014505 SAM binding site [chemical binding]; other site 1052684014506 homodimer interface [polypeptide binding]; other site 1052684014507 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 1052684014508 active site 1052684014509 putative homodimer interface [polypeptide binding]; other site 1052684014510 SAM binding site [chemical binding]; other site 1052684014511 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 1052684014512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684014513 S-adenosylmethionine binding site [chemical binding]; other site 1052684014514 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 1052684014515 Precorrin-8X methylmutase; Region: CbiC; pfam02570 1052684014516 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 1052684014517 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 1052684014518 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 1052684014519 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 1052684014520 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1052684014521 putative active site [active] 1052684014522 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 1052684014523 putative active site [active] 1052684014524 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 1052684014525 active site 1052684014526 SAM binding site [chemical binding]; other site 1052684014527 homodimer interface [polypeptide binding]; other site 1052684014528 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 1052684014529 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1052684014530 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1052684014531 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1052684014532 active site 1052684014533 Spore germination protein; Region: Spore_permease; cl17796 1052684014534 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052684014535 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052684014536 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052684014537 Pirin-related protein [General function prediction only]; Region: COG1741 1052684014538 Pirin; Region: Pirin; pfam02678 1052684014539 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 1052684014540 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684014541 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684014542 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1052684014543 putative dimerization interface [polypeptide binding]; other site 1052684014544 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1052684014545 EamA-like transporter family; Region: EamA; pfam00892 1052684014546 Cache domain; Region: Cache_1; pfam02743 1052684014547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684014548 dimerization interface [polypeptide binding]; other site 1052684014549 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1052684014550 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684014551 dimer interface [polypeptide binding]; other site 1052684014552 putative CheW interface [polypeptide binding]; other site 1052684014553 Predicted membrane protein [Function unknown]; Region: COG2259 1052684014554 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 1052684014555 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1052684014556 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684014557 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684014558 DNA binding site [nucleotide binding] 1052684014559 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1052684014560 metal binding site 2 [ion binding]; metal-binding site 1052684014561 putative DNA binding helix; other site 1052684014562 metal binding site 1 [ion binding]; metal-binding site 1052684014563 dimer interface [polypeptide binding]; other site 1052684014564 structural Zn2+ binding site [ion binding]; other site 1052684014565 Spore germination protein; Region: Spore_permease; cl17796 1052684014566 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 1052684014567 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 1052684014568 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 1052684014569 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1052684014570 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052684014571 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052684014572 metal binding site [ion binding]; metal-binding site 1052684014573 active site 1052684014574 I-site; other site 1052684014575 Transcriptional regulator; Region: Rrf2; pfam02082 1052684014576 Rrf2 family protein; Region: rrf2_super; TIGR00738 1052684014577 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1052684014578 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1052684014579 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1052684014580 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 1052684014581 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1052684014582 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 1052684014583 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1052684014584 effector binding site; other site 1052684014585 active site 1052684014586 Zn binding site [ion binding]; other site 1052684014587 glycine loop; other site 1052684014588 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 1052684014589 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1052684014590 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1052684014591 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1052684014592 THF binding site; other site 1052684014593 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1052684014594 substrate binding site [chemical binding]; other site 1052684014595 THF binding site; other site 1052684014596 zinc-binding site [ion binding]; other site 1052684014597 Predicted transcriptional regulators [Transcription]; Region: COG1695 1052684014598 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1052684014599 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 1052684014600 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1052684014601 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052684014602 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1052684014603 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 1052684014604 classical (c) SDRs; Region: SDR_c; cd05233 1052684014605 NAD(P) binding site [chemical binding]; other site 1052684014606 active site 1052684014607 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1052684014608 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1052684014609 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1052684014610 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 1052684014611 active site 1052684014612 dimer interface [polypeptide binding]; other site 1052684014613 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1052684014614 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1052684014615 dimerization interface [polypeptide binding]; other site 1052684014616 DPS ferroxidase diiron center [ion binding]; other site 1052684014617 ion pore; other site 1052684014618 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1052684014619 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052684014620 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052684014621 active site 1052684014622 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1052684014623 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1052684014624 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684014625 Walker A/P-loop; other site 1052684014626 ATP binding site [chemical binding]; other site 1052684014627 Q-loop/lid; other site 1052684014628 ABC transporter signature motif; other site 1052684014629 Walker B; other site 1052684014630 D-loop; other site 1052684014631 H-loop/switch region; other site 1052684014632 TOBE domain; Region: TOBE_2; pfam08402 1052684014633 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1052684014634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684014635 dimer interface [polypeptide binding]; other site 1052684014636 conserved gate region; other site 1052684014637 putative PBP binding loops; other site 1052684014638 ABC-ATPase subunit interface; other site 1052684014639 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1052684014640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684014641 dimer interface [polypeptide binding]; other site 1052684014642 conserved gate region; other site 1052684014643 putative PBP binding loops; other site 1052684014644 ABC-ATPase subunit interface; other site 1052684014645 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1052684014646 active site 1052684014647 tetramer interface [polypeptide binding]; other site 1052684014648 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1052684014649 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1052684014650 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1052684014651 nucleophilic elbow; other site 1052684014652 catalytic triad; other site 1052684014653 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1052684014654 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1052684014655 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 1052684014656 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1052684014657 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1052684014658 GAF domain; Region: GAF_3; pfam13492 1052684014659 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684014660 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684014661 ATP binding site [chemical binding]; other site 1052684014662 Mg2+ binding site [ion binding]; other site 1052684014663 G-X-G motif; other site 1052684014664 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 1052684014665 active site 1052684014666 dimerization interface [polypeptide binding]; other site 1052684014667 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1052684014668 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1052684014669 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1052684014670 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1052684014671 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1052684014672 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1052684014673 putative DNA binding site [nucleotide binding]; other site 1052684014674 putative Zn2+ binding site [ion binding]; other site 1052684014675 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1052684014676 DEAD_2; Region: DEAD_2; pfam06733 1052684014677 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1052684014678 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1052684014679 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052684014680 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052684014681 metal binding site [ion binding]; metal-binding site 1052684014682 active site 1052684014683 I-site; other site 1052684014684 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684014685 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684014686 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 1052684014687 putative dimerization interface [polypeptide binding]; other site 1052684014688 holin-like protein; Validated; Region: PRK01658 1052684014689 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 1052684014690 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1052684014691 glycerol kinase; Provisional; Region: glpK; PRK00047 1052684014692 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1052684014693 N- and C-terminal domain interface [polypeptide binding]; other site 1052684014694 active site 1052684014695 MgATP binding site [chemical binding]; other site 1052684014696 catalytic site [active] 1052684014697 metal binding site [ion binding]; metal-binding site 1052684014698 glycerol binding site [chemical binding]; other site 1052684014699 homotetramer interface [polypeptide binding]; other site 1052684014700 homodimer interface [polypeptide binding]; other site 1052684014701 FBP binding site [chemical binding]; other site 1052684014702 protein IIAGlc interface [polypeptide binding]; other site 1052684014703 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1052684014704 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1052684014705 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1052684014706 substrate binding pocket [chemical binding]; other site 1052684014707 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052684014708 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1052684014709 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052684014710 NAD binding site [chemical binding]; other site 1052684014711 substrate binding site [chemical binding]; other site 1052684014712 putative active site [active] 1052684014713 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1052684014714 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1052684014715 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052684014716 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052684014717 H+ Antiporter protein; Region: 2A0121; TIGR00900 1052684014718 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684014719 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684014720 DNA binding site [nucleotide binding] 1052684014721 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1052684014722 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684014723 putative substrate translocation pore; other site 1052684014724 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1052684014725 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1052684014726 NADP binding site [chemical binding]; other site 1052684014727 homodimer interface [polypeptide binding]; other site 1052684014728 active site 1052684014729 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1052684014730 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1052684014731 active site 1052684014732 intersubunit interface [polypeptide binding]; other site 1052684014733 catalytic residue [active] 1052684014734 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1052684014735 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1052684014736 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1052684014737 substrate binding site [chemical binding]; other site 1052684014738 ATP binding site [chemical binding]; other site 1052684014739 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684014740 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684014741 DNA binding site [nucleotide binding] 1052684014742 domain linker motif; other site 1052684014743 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 1052684014744 putative dimerization interface [polypeptide binding]; other site 1052684014745 putative ligand binding site [chemical binding]; other site 1052684014746 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 1052684014747 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1052684014748 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1052684014749 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1052684014750 NAD(P) binding site [chemical binding]; other site 1052684014751 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1052684014752 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684014753 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684014754 DNA binding residues [nucleotide binding] 1052684014755 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1052684014756 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684014757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684014758 putative PBP binding loops; other site 1052684014759 dimer interface [polypeptide binding]; other site 1052684014760 ABC-ATPase subunit interface; other site 1052684014761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684014762 dimer interface [polypeptide binding]; other site 1052684014763 conserved gate region; other site 1052684014764 putative PBP binding loops; other site 1052684014765 ABC-ATPase subunit interface; other site 1052684014766 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684014767 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684014768 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1052684014769 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684014770 Walker A/P-loop; other site 1052684014771 ATP binding site [chemical binding]; other site 1052684014772 Q-loop/lid; other site 1052684014773 ABC transporter signature motif; other site 1052684014774 Walker B; other site 1052684014775 D-loop; other site 1052684014776 H-loop/switch region; other site 1052684014777 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1052684014778 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684014779 Walker A/P-loop; other site 1052684014780 ATP binding site [chemical binding]; other site 1052684014781 Q-loop/lid; other site 1052684014782 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052684014783 ABC transporter signature motif; other site 1052684014784 Walker B; other site 1052684014785 D-loop; other site 1052684014786 ABC transporter; Region: ABC_tran_2; pfam12848 1052684014787 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1052684014788 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1052684014789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1052684014790 putative substrate translocation pore; other site 1052684014791 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1052684014792 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1052684014793 Domain of unknown function (DUF377); Region: DUF377; pfam04041 1052684014794 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1052684014795 active site 1052684014796 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684014797 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684014798 dimer interface [polypeptide binding]; other site 1052684014799 conserved gate region; other site 1052684014800 putative PBP binding loops; other site 1052684014801 ABC-ATPase subunit interface; other site 1052684014802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684014803 dimer interface [polypeptide binding]; other site 1052684014804 conserved gate region; other site 1052684014805 putative PBP binding loops; other site 1052684014806 ABC-ATPase subunit interface; other site 1052684014807 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684014808 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1052684014809 dimerization interface [polypeptide binding]; other site 1052684014810 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1052684014811 putative active cleft [active] 1052684014812 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1052684014813 active site 1052684014814 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684014815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1052684014816 DNA binding site [nucleotide binding] 1052684014817 domain linker motif; other site 1052684014818 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1052684014819 hypothetical protein; Provisional; Region: PRK04164 1052684014820 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1052684014821 CsbD-like; Region: CsbD; pfam05532 1052684014822 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684014823 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684014824 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1052684014825 substrate binding site [chemical binding]; other site 1052684014826 active site 1052684014827 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1052684014828 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1052684014829 Uncharacterized conserved protein [Function unknown]; Region: COG2427 1052684014830 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1052684014831 active site residue [active] 1052684014832 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1052684014833 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1052684014834 active site 1052684014835 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1052684014836 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1052684014837 active site 1052684014838 Na/Ca binding site [ion binding]; other site 1052684014839 catalytic site [active] 1052684014840 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1052684014841 catalytic core [active] 1052684014842 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1052684014843 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1052684014844 peptidase T; Region: peptidase-T; TIGR01882 1052684014845 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1052684014846 metal binding site [ion binding]; metal-binding site 1052684014847 dimer interface [polypeptide binding]; other site 1052684014848 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684014849 dimer interface [polypeptide binding]; other site 1052684014850 putative CheW interface [polypeptide binding]; other site 1052684014851 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1052684014852 active site 1052684014853 dimer interface [polypeptide binding]; other site 1052684014854 magnesium binding site [ion binding]; other site 1052684014855 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1052684014856 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 1052684014857 tetramer interface [polypeptide binding]; other site 1052684014858 active site 1052684014859 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1052684014860 active site 1052684014861 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 1052684014862 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1052684014863 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1052684014864 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1052684014865 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684014866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684014867 dimer interface [polypeptide binding]; other site 1052684014868 conserved gate region; other site 1052684014869 ABC-ATPase subunit interface; other site 1052684014870 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1052684014871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684014872 dimer interface [polypeptide binding]; other site 1052684014873 conserved gate region; other site 1052684014874 ABC-ATPase subunit interface; other site 1052684014875 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684014876 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1052684014877 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052684014878 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052684014879 Walker A/P-loop; other site 1052684014880 ATP binding site [chemical binding]; other site 1052684014881 Q-loop/lid; other site 1052684014882 ABC transporter signature motif; other site 1052684014883 Walker B; other site 1052684014884 D-loop; other site 1052684014885 H-loop/switch region; other site 1052684014886 FtsX-like permease family; Region: FtsX; pfam02687 1052684014887 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1052684014888 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052684014889 HAMP domain; Region: HAMP; pfam00672 1052684014890 Histidine kinase; Region: His_kinase; pfam06580 1052684014891 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684014892 ATP binding site [chemical binding]; other site 1052684014893 Mg2+ binding site [ion binding]; other site 1052684014894 G-X-G motif; other site 1052684014895 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684014896 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1052684014897 active site 1052684014898 phosphorylation site [posttranslational modification] 1052684014899 intermolecular recognition site; other site 1052684014900 dimerization interface [polypeptide binding]; other site 1052684014901 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684014902 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1052684014903 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1052684014904 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1052684014905 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1052684014906 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1052684014907 Rubredoxin [Energy production and conversion]; Region: COG1773 1052684014908 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1052684014909 iron binding site [ion binding]; other site 1052684014910 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1052684014911 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1052684014912 ligand binding site [chemical binding]; other site 1052684014913 flexible hinge region; other site 1052684014914 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1052684014915 putative switch regulator; other site 1052684014916 non-specific DNA interactions [nucleotide binding]; other site 1052684014917 DNA binding site [nucleotide binding] 1052684014918 sequence specific DNA binding site [nucleotide binding]; other site 1052684014919 putative cAMP binding site [chemical binding]; other site 1052684014920 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 1052684014921 Predicted integral membrane protein [Function unknown]; Region: COG5542 1052684014922 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1052684014923 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 1052684014924 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1052684014925 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1052684014926 NAD(P) binding site [chemical binding]; other site 1052684014927 putative active site [active] 1052684014928 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684014929 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684014930 WHG domain; Region: WHG; pfam13305 1052684014931 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1052684014932 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1052684014933 Walker A/P-loop; other site 1052684014934 ATP binding site [chemical binding]; other site 1052684014935 Q-loop/lid; other site 1052684014936 ABC transporter signature motif; other site 1052684014937 Walker B; other site 1052684014938 D-loop; other site 1052684014939 H-loop/switch region; other site 1052684014940 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 1052684014941 General stress protein [General function prediction only]; Region: GsiB; COG3729 1052684014942 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684014943 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684014944 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1052684014945 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684014946 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684014947 Helix-turn-helix domain; Region: HTH_18; pfam12833 1052684014948 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684014949 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 1052684014950 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 1052684014951 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 1052684014952 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 1052684014953 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; pfam01373 1052684014954 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 1052684014955 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 1052684014956 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 1052684014957 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1052684014958 active site 1052684014959 catalytic site [active] 1052684014960 Aamy_C domain; Region: Aamy_C; smart00632 1052684014961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 1052684014962 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052684014963 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1052684014964 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052684014965 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1052684014966 Walker A/P-loop; other site 1052684014967 ATP binding site [chemical binding]; other site 1052684014968 Q-loop/lid; other site 1052684014969 ABC transporter signature motif; other site 1052684014970 Walker B; other site 1052684014971 D-loop; other site 1052684014972 H-loop/switch region; other site 1052684014973 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1052684014974 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1052684014975 active site 1052684014976 FMN binding site [chemical binding]; other site 1052684014977 substrate binding site [chemical binding]; other site 1052684014978 homotetramer interface [polypeptide binding]; other site 1052684014979 catalytic residue [active] 1052684014980 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1052684014981 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1052684014982 Response regulator receiver domain; Region: Response_reg; pfam00072 1052684014983 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684014984 active site 1052684014985 phosphorylation site [posttranslational modification] 1052684014986 intermolecular recognition site; other site 1052684014987 dimerization interface [polypeptide binding]; other site 1052684014988 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684014989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684014990 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1052684014991 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684014992 dimerization interface [polypeptide binding]; other site 1052684014993 Histidine kinase; Region: His_kinase; pfam06580 1052684014994 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684014995 ATP binding site [chemical binding]; other site 1052684014996 Mg2+ binding site [ion binding]; other site 1052684014997 G-X-G motif; other site 1052684014998 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1052684014999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684015000 dimer interface [polypeptide binding]; other site 1052684015001 conserved gate region; other site 1052684015002 putative PBP binding loops; other site 1052684015003 ABC-ATPase subunit interface; other site 1052684015004 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1052684015005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684015006 dimer interface [polypeptide binding]; other site 1052684015007 conserved gate region; other site 1052684015008 putative PBP binding loops; other site 1052684015009 ABC-ATPase subunit interface; other site 1052684015010 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1052684015011 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052684015012 Catalytic site [active] 1052684015013 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1052684015014 Right handed beta helix region; Region: Beta_helix; pfam13229 1052684015015 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1052684015016 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1052684015017 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1052684015018 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1052684015019 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 1052684015020 NodB motif; other site 1052684015021 active site 1052684015022 catalytic site [active] 1052684015023 Zn binding site [ion binding]; other site 1052684015024 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1052684015025 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1052684015026 catalytic triad [active] 1052684015027 catalytic triad [active] 1052684015028 oxyanion hole [active] 1052684015029 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 1052684015030 putative substrate binding site 1 [chemical binding]; other site 1052684015031 Na binding site 1 [ion binding]; other site 1052684015032 putative substrate binding site 2 [chemical binding]; other site 1052684015033 Na2 binding site [ion binding]; other site 1052684015034 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 1052684015035 seryl-tRNA synthetase; Provisional; Region: PRK05431 1052684015036 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1052684015037 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1052684015038 dimer interface [polypeptide binding]; other site 1052684015039 active site 1052684015040 motif 1; other site 1052684015041 motif 2; other site 1052684015042 motif 3; other site 1052684015043 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1052684015044 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1052684015045 heme-binding site [chemical binding]; other site 1052684015046 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1052684015047 FAD binding pocket [chemical binding]; other site 1052684015048 FAD binding motif [chemical binding]; other site 1052684015049 phosphate binding motif [ion binding]; other site 1052684015050 beta-alpha-beta structure motif; other site 1052684015051 NAD binding pocket [chemical binding]; other site 1052684015052 Heme binding pocket [chemical binding]; other site 1052684015053 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 1052684015054 active site 1052684015055 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1052684015056 sugar binding site [chemical binding]; other site 1052684015057 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1052684015058 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684015059 DNA-binding site [nucleotide binding]; DNA binding site 1052684015060 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1052684015061 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1052684015062 beta-galactosidase; Region: BGL; TIGR03356 1052684015063 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1052684015064 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 1052684015065 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1052684015066 active site 1052684015067 methionine cluster; other site 1052684015068 phosphorylation site [posttranslational modification] 1052684015069 metal binding site [ion binding]; metal-binding site 1052684015070 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1052684015071 active site 1052684015072 P-loop; other site 1052684015073 phosphorylation site [posttranslational modification] 1052684015074 KWG Leptospira; Region: KWG; pfam07656 1052684015075 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1052684015076 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1052684015077 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1052684015078 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1052684015079 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684015080 non-specific DNA binding site [nucleotide binding]; other site 1052684015081 salt bridge; other site 1052684015082 sequence-specific DNA binding site [nucleotide binding]; other site 1052684015083 Predicted transcriptional regulator [Transcription]; Region: COG2378 1052684015084 HTH domain; Region: HTH_11; pfam08279 1052684015085 WYL domain; Region: WYL; pfam13280 1052684015086 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1052684015087 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1052684015088 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1052684015089 active site 1052684015090 homodimer interface [polypeptide binding]; other site 1052684015091 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1052684015092 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1052684015093 Walker A/P-loop; other site 1052684015094 ATP binding site [chemical binding]; other site 1052684015095 Q-loop/lid; other site 1052684015096 ABC transporter signature motif; other site 1052684015097 Walker B; other site 1052684015098 D-loop; other site 1052684015099 H-loop/switch region; other site 1052684015100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684015101 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1052684015102 dimer interface [polypeptide binding]; other site 1052684015103 conserved gate region; other site 1052684015104 putative PBP binding loops; other site 1052684015105 ABC-ATPase subunit interface; other site 1052684015106 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1052684015107 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1052684015108 substrate binding pocket [chemical binding]; other site 1052684015109 membrane-bound complex binding site; other site 1052684015110 hinge residues; other site 1052684015111 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 1052684015112 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052684015113 Walker A/P-loop; other site 1052684015114 ATP binding site [chemical binding]; other site 1052684015115 Q-loop/lid; other site 1052684015116 ABC transporter signature motif; other site 1052684015117 Walker B; other site 1052684015118 D-loop; other site 1052684015119 H-loop/switch region; other site 1052684015120 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052684015121 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 1052684015122 Walker A/P-loop; other site 1052684015123 ATP binding site [chemical binding]; other site 1052684015124 Q-loop/lid; other site 1052684015125 ABC transporter signature motif; other site 1052684015126 Walker B; other site 1052684015127 D-loop; other site 1052684015128 H-loop/switch region; other site 1052684015129 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1052684015130 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052684015131 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1052684015132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684015133 dimer interface [polypeptide binding]; other site 1052684015134 conserved gate region; other site 1052684015135 putative PBP binding loops; other site 1052684015136 ABC-ATPase subunit interface; other site 1052684015137 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 1052684015138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684015139 dimer interface [polypeptide binding]; other site 1052684015140 conserved gate region; other site 1052684015141 putative PBP binding loops; other site 1052684015142 ABC-ATPase subunit interface; other site 1052684015143 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1052684015144 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1052684015145 substrate binding site [chemical binding]; other site 1052684015146 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1052684015147 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052684015148 Walker A/P-loop; other site 1052684015149 ATP binding site [chemical binding]; other site 1052684015150 Q-loop/lid; other site 1052684015151 ABC transporter signature motif; other site 1052684015152 Walker B; other site 1052684015153 D-loop; other site 1052684015154 H-loop/switch region; other site 1052684015155 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052684015156 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1052684015157 Walker A/P-loop; other site 1052684015158 ATP binding site [chemical binding]; other site 1052684015159 Q-loop/lid; other site 1052684015160 ABC transporter signature motif; other site 1052684015161 Walker B; other site 1052684015162 D-loop; other site 1052684015163 H-loop/switch region; other site 1052684015164 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1052684015165 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684015166 dimer interface [polypeptide binding]; other site 1052684015167 conserved gate region; other site 1052684015168 putative PBP binding loops; other site 1052684015169 ABC-ATPase subunit interface; other site 1052684015170 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052684015171 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684015172 dimer interface [polypeptide binding]; other site 1052684015173 conserved gate region; other site 1052684015174 putative PBP binding loops; other site 1052684015175 ABC-ATPase subunit interface; other site 1052684015176 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1052684015177 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 1052684015178 xanthine permease; Region: pbuX; TIGR03173 1052684015179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1052684015180 active site 1052684015181 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1052684015182 N- and C-terminal domain interface [polypeptide binding]; other site 1052684015183 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1052684015184 active site 1052684015185 putative catalytic site [active] 1052684015186 metal binding site [ion binding]; metal-binding site 1052684015187 ATP binding site [chemical binding]; other site 1052684015188 carbohydrate binding site [chemical binding]; other site 1052684015189 L-rhamnose isomerase; Provisional; Region: PRK01076 1052684015190 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1052684015191 intersubunit interface [polypeptide binding]; other site 1052684015192 active site 1052684015193 Zn2+ binding site [ion binding]; other site 1052684015194 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1052684015195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684015196 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684015197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684015198 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 1052684015199 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 1052684015200 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1052684015201 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1052684015202 Membrane transport protein; Region: Mem_trans; cl09117 1052684015203 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1052684015204 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 1052684015205 putative homodimer interface [polypeptide binding]; other site 1052684015206 putative ligand binding site [chemical binding]; other site 1052684015207 putative NAD binding site [chemical binding]; other site 1052684015208 catalytic site [active] 1052684015209 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 1052684015210 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684015211 active site 1052684015212 phosphorylation site [posttranslational modification] 1052684015213 intermolecular recognition site; other site 1052684015214 dimerization interface [polypeptide binding]; other site 1052684015215 HTH domain; Region: HTH_11; pfam08279 1052684015216 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 1052684015217 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684015218 ATP binding site [chemical binding]; other site 1052684015219 Mg2+ binding site [ion binding]; other site 1052684015220 G-X-G motif; other site 1052684015221 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1052684015222 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1052684015223 heterodimer interface [polypeptide binding]; other site 1052684015224 active site 1052684015225 FMN binding site [chemical binding]; other site 1052684015226 homodimer interface [polypeptide binding]; other site 1052684015227 substrate binding site [chemical binding]; other site 1052684015228 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1052684015229 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1052684015230 FAD binding pocket [chemical binding]; other site 1052684015231 FAD binding motif [chemical binding]; other site 1052684015232 phosphate binding motif [ion binding]; other site 1052684015233 beta-alpha-beta structure motif; other site 1052684015234 NAD binding pocket [chemical binding]; other site 1052684015235 Iron coordination center [ion binding]; other site 1052684015236 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1052684015237 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684015238 FeS/SAM binding site; other site 1052684015239 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684015240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684015241 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1052684015242 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1052684015243 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1052684015244 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1052684015245 dimerization interface [polypeptide binding]; other site 1052684015246 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 1052684015247 classical (c) SDRs; Region: SDR_c; cd05233 1052684015248 NAD(P) binding site [chemical binding]; other site 1052684015249 active site 1052684015250 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 1052684015251 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1052684015252 catalytic residues [active] 1052684015253 dimer interface [polypeptide binding]; other site 1052684015254 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1052684015255 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684015256 DNA-binding interface [nucleotide binding]; DNA binding site 1052684015257 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1052684015258 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 1052684015259 NADP binding site [chemical binding]; other site 1052684015260 homodimer interface [polypeptide binding]; other site 1052684015261 active site 1052684015262 substrate binding site [chemical binding]; other site 1052684015263 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1052684015264 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1052684015265 ligand binding site [chemical binding]; other site 1052684015266 flexible hinge region; other site 1052684015267 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1052684015268 non-specific DNA interactions [nucleotide binding]; other site 1052684015269 DNA binding site [nucleotide binding] 1052684015270 sequence specific DNA binding site [nucleotide binding]; other site 1052684015271 putative cAMP binding site [chemical binding]; other site 1052684015272 DinB superfamily; Region: DinB_2; pfam12867 1052684015273 Predicted transcriptional regulator [Transcription]; Region: COG2378 1052684015274 HTH domain; Region: HTH_11; pfam08279 1052684015275 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1052684015276 WYL domain; Region: WYL; pfam13280 1052684015277 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1052684015278 GIY-YIG motif/motif A; other site 1052684015279 active site 1052684015280 catalytic site [active] 1052684015281 putative DNA binding site [nucleotide binding]; other site 1052684015282 metal binding site [ion binding]; metal-binding site 1052684015283 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 1052684015284 Predicted transcriptional regulators [Transcription]; Region: COG1733 1052684015285 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1052684015286 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 1052684015287 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1052684015288 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1052684015289 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 1052684015290 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 1052684015291 [2Fe-2S] cluster binding site [ion binding]; other site 1052684015292 Coat F domain; Region: Coat_F; cl17715 1052684015293 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1052684015294 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1052684015295 NAD binding site [chemical binding]; other site 1052684015296 catalytic Zn binding site [ion binding]; other site 1052684015297 structural Zn binding site [ion binding]; other site 1052684015298 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 1052684015299 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052684015300 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052684015301 active site 1052684015302 catalytic tetrad [active] 1052684015303 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1052684015304 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1052684015305 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1052684015306 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1052684015307 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1052684015308 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1052684015309 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1052684015310 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1052684015311 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052684015312 Zn2+ binding site [ion binding]; other site 1052684015313 Mg2+ binding site [ion binding]; other site 1052684015314 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684015315 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684015316 active site 1052684015317 phosphorylation site [posttranslational modification] 1052684015318 intermolecular recognition site; other site 1052684015319 dimerization interface [polypeptide binding]; other site 1052684015320 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684015321 DNA binding site [nucleotide binding] 1052684015322 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1052684015323 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684015324 ATP binding site [chemical binding]; other site 1052684015325 Mg2+ binding site [ion binding]; other site 1052684015326 G-X-G motif; other site 1052684015327 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052684015328 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052684015329 Walker A/P-loop; other site 1052684015330 ATP binding site [chemical binding]; other site 1052684015331 Q-loop/lid; other site 1052684015332 ABC transporter signature motif; other site 1052684015333 Walker B; other site 1052684015334 D-loop; other site 1052684015335 H-loop/switch region; other site 1052684015336 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1052684015337 FtsX-like permease family; Region: FtsX; pfam02687 1052684015338 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1052684015339 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1052684015340 active site 1052684015341 catalytic tetrad [active] 1052684015342 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 1052684015343 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684015344 FeS/SAM binding site; other site 1052684015345 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 1052684015346 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1052684015347 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052684015348 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052684015349 catalytic residue [active] 1052684015350 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1052684015351 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1052684015352 Uncharacterized conserved protein [Function unknown]; Region: COG2013 1052684015353 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1052684015354 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1052684015355 PhnA protein; Region: PhnA; pfam03831 1052684015356 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1052684015357 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1052684015358 NADP binding site [chemical binding]; other site 1052684015359 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1052684015360 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1052684015361 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1052684015362 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1052684015363 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1052684015364 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 1052684015365 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1052684015366 active site 1052684015367 P-loop; other site 1052684015368 phosphorylation site [posttranslational modification] 1052684015369 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1052684015370 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1052684015371 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052684015372 active site 1052684015373 phosphorylation site [posttranslational modification] 1052684015374 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1052684015375 HTH domain; Region: HTH_11; pfam08279 1052684015376 Mga helix-turn-helix domain; Region: Mga; pfam05043 1052684015377 PRD domain; Region: PRD; pfam00874 1052684015378 PRD domain; Region: PRD; pfam00874 1052684015379 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1052684015380 active site 1052684015381 P-loop; other site 1052684015382 phosphorylation site [posttranslational modification] 1052684015383 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1052684015384 active site 1052684015385 phosphorylation site [posttranslational modification] 1052684015386 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684015387 Coenzyme A binding pocket [chemical binding]; other site 1052684015388 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1052684015389 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684015390 Coenzyme A binding pocket [chemical binding]; other site 1052684015391 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1052684015392 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1052684015393 RDD family; Region: RDD; pfam06271 1052684015394 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 1052684015395 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1052684015396 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1052684015397 glycerate kinase; Region: TIGR00045 1052684015398 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 1052684015399 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1052684015400 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1052684015401 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684015402 DNA-binding site [nucleotide binding]; DNA binding site 1052684015403 FCD domain; Region: FCD; pfam07729 1052684015404 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 1052684015405 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 1052684015406 N- and C-terminal domain interface [polypeptide binding]; other site 1052684015407 active site 1052684015408 catalytic site [active] 1052684015409 metal binding site [ion binding]; metal-binding site 1052684015410 carbohydrate binding site [chemical binding]; other site 1052684015411 ATP binding site [chemical binding]; other site 1052684015412 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1052684015413 gluconate transporter; Region: gntP; TIGR00791 1052684015414 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1052684015415 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684015416 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684015417 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1052684015418 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1052684015419 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1052684015420 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 1052684015421 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 1052684015422 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684015423 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684015424 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 1052684015425 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1052684015426 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1052684015427 ATP binding site [chemical binding]; other site 1052684015428 Mg++ binding site [ion binding]; other site 1052684015429 motif III; other site 1052684015430 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1052684015431 nucleotide binding region [chemical binding]; other site 1052684015432 ATP-binding site [chemical binding]; other site 1052684015433 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 1052684015434 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1052684015435 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 1052684015436 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684015437 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684015438 DNA binding residues [nucleotide binding] 1052684015439 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1052684015440 catalytic core [active] 1052684015441 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 1052684015442 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 1052684015443 NADP binding site [chemical binding]; other site 1052684015444 active site 1052684015445 substrate binding site [chemical binding]; other site 1052684015446 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1052684015447 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1052684015448 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1052684015449 malate:quinone oxidoreductase; Validated; Region: PRK05257 1052684015450 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1052684015451 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1052684015452 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684015453 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684015454 DNA binding residues [nucleotide binding] 1052684015455 L-arabinose isomerase; Provisional; Region: PRK02929 1052684015456 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1052684015457 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1052684015458 trimer interface [polypeptide binding]; other site 1052684015459 substrate binding site [chemical binding]; other site 1052684015460 Mn binding site [ion binding]; other site 1052684015461 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1052684015462 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1052684015463 intersubunit interface [polypeptide binding]; other site 1052684015464 active site 1052684015465 Zn2+ binding site [ion binding]; other site 1052684015466 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1052684015467 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1052684015468 putative N- and C-terminal domain interface [polypeptide binding]; other site 1052684015469 putative active site [active] 1052684015470 MgATP binding site [chemical binding]; other site 1052684015471 catalytic site [active] 1052684015472 metal binding site [ion binding]; metal-binding site 1052684015473 putative carbohydrate binding site [chemical binding]; other site 1052684015474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1052684015475 DNA-binding site [nucleotide binding]; DNA binding site 1052684015476 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1052684015477 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 1052684015478 putative dimerization interface [polypeptide binding]; other site 1052684015479 putative ligand binding site [chemical binding]; other site 1052684015480 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1052684015481 Beta-lactamase; Region: Beta-lactamase; pfam00144 1052684015482 S-layer homology domain; Region: SLH; pfam00395 1052684015483 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 1052684015484 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1052684015485 Fe-S cluster binding site [ion binding]; other site 1052684015486 active site 1052684015487 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 1052684015488 active site 1052684015489 catalytic site [active] 1052684015490 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1052684015491 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 1052684015492 Berberine and berberine like; Region: BBE; pfam08031 1052684015493 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1052684015494 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1052684015495 G1 box; other site 1052684015496 putative GEF interaction site [polypeptide binding]; other site 1052684015497 GTP/Mg2+ binding site [chemical binding]; other site 1052684015498 Switch I region; other site 1052684015499 G2 box; other site 1052684015500 G3 box; other site 1052684015501 Switch II region; other site 1052684015502 G4 box; other site 1052684015503 G5 box; other site 1052684015504 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 1052684015505 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1052684015506 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1052684015507 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 1052684015508 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 1052684015509 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684015510 dimerization interface [polypeptide binding]; other site 1052684015511 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1052684015512 dimer interface [polypeptide binding]; other site 1052684015513 putative CheW interface [polypeptide binding]; other site 1052684015514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1052684015515 binding surface 1052684015516 TPR motif; other site 1052684015517 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1052684015518 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1052684015519 GTP-binding protein YchF; Reviewed; Region: PRK09601 1052684015520 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052684015521 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684015522 non-specific DNA binding site [nucleotide binding]; other site 1052684015523 salt bridge; other site 1052684015524 sequence-specific DNA binding site [nucleotide binding]; other site 1052684015525 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684015526 non-specific DNA binding site [nucleotide binding]; other site 1052684015527 salt bridge; other site 1052684015528 sequence-specific DNA binding site [nucleotide binding]; other site 1052684015529 DinB family; Region: DinB; cl17821 1052684015530 Helix-turn-helix domain; Region: HTH_18; pfam12833 1052684015531 YyzF-like protein; Region: YyzF; pfam14116 1052684015532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684015533 S-adenosylmethionine binding site [chemical binding]; other site 1052684015534 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 1052684015535 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1052684015536 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 1052684015537 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1052684015538 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1052684015539 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1052684015540 protein binding site [polypeptide binding]; other site 1052684015541 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 1052684015542 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1052684015543 YycH protein; Region: YycI; cl02015 1052684015544 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 1052684015545 YycH protein; Region: YycH; pfam07435 1052684015546 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1052684015547 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1052684015548 dimerization interface [polypeptide binding]; other site 1052684015549 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1052684015550 putative active site [active] 1052684015551 heme pocket [chemical binding]; other site 1052684015552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1052684015553 dimer interface [polypeptide binding]; other site 1052684015554 phosphorylation site [posttranslational modification] 1052684015555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684015556 ATP binding site [chemical binding]; other site 1052684015557 Mg2+ binding site [ion binding]; other site 1052684015558 G-X-G motif; other site 1052684015559 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1052684015560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1052684015561 active site 1052684015562 phosphorylation site [posttranslational modification] 1052684015563 intermolecular recognition site; other site 1052684015564 dimerization interface [polypeptide binding]; other site 1052684015565 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1052684015566 DNA binding site [nucleotide binding] 1052684015567 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1052684015568 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1052684015569 G5 domain; Region: G5; pfam07501 1052684015570 Peptidase family M23; Region: Peptidase_M23; pfam01551 1052684015571 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1052684015572 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1052684015573 GDP-binding site [chemical binding]; other site 1052684015574 ACT binding site; other site 1052684015575 IMP binding site; other site 1052684015576 replicative DNA helicase; Provisional; Region: PRK05748 1052684015577 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1052684015578 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1052684015579 Walker A motif; other site 1052684015580 ATP binding site [chemical binding]; other site 1052684015581 Walker B motif; other site 1052684015582 DNA binding loops [nucleotide binding] 1052684015583 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1052684015584 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1052684015585 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1052684015586 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1052684015587 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1052684015588 DHH family; Region: DHH; pfam01368 1052684015589 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 1052684015590 MazG-like family; Region: MazG-like; pfam12643 1052684015591 FOG: CBS domain [General function prediction only]; Region: COG0517 1052684015592 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1052684015593 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1052684015594 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1052684015595 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1052684015596 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1052684015597 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052684015598 Walker A/P-loop; other site 1052684015599 ATP binding site [chemical binding]; other site 1052684015600 Q-loop/lid; other site 1052684015601 ABC transporter signature motif; other site 1052684015602 Walker B; other site 1052684015603 D-loop; other site 1052684015604 H-loop/switch region; other site 1052684015605 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1052684015606 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1052684015607 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1052684015608 Walker A/P-loop; other site 1052684015609 ATP binding site [chemical binding]; other site 1052684015610 Q-loop/lid; other site 1052684015611 ABC transporter signature motif; other site 1052684015612 Walker B; other site 1052684015613 D-loop; other site 1052684015614 H-loop/switch region; other site 1052684015615 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1052684015616 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1052684015617 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1052684015618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684015619 dimer interface [polypeptide binding]; other site 1052684015620 conserved gate region; other site 1052684015621 putative PBP binding loops; other site 1052684015622 ABC-ATPase subunit interface; other site 1052684015623 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1052684015624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1052684015625 dimer interface [polypeptide binding]; other site 1052684015626 conserved gate region; other site 1052684015627 putative PBP binding loops; other site 1052684015628 ABC-ATPase subunit interface; other site 1052684015629 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1052684015630 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1052684015631 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1052684015632 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1052684015633 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1052684015634 dimer interface [polypeptide binding]; other site 1052684015635 ssDNA binding site [nucleotide binding]; other site 1052684015636 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052684015637 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1052684015638 YjzC-like protein; Region: YjzC; pfam14168 1052684015639 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1052684015640 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1052684015641 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1052684015642 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 1052684015643 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1052684015644 ParB-like nuclease domain; Region: ParB; smart00470 1052684015645 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1052684015646 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1052684015647 P-loop; other site 1052684015648 Magnesium ion binding site [ion binding]; other site 1052684015649 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1052684015650 Magnesium ion binding site [ion binding]; other site 1052684015651 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1052684015652 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 1052684015653 ParB-like nuclease domain; Region: ParB; smart00470 1052684015654 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1052684015655 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684015656 S-adenosylmethionine binding site [chemical binding]; other site 1052684015657 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1052684015658 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 1052684015659 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1052684015660 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1052684015661 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1052684015662 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1052684015663 G1 box; other site 1052684015664 GTP/Mg2+ binding site [chemical binding]; other site 1052684015665 Switch I region; other site 1052684015666 G2 box; other site 1052684015667 Switch II region; other site 1052684015668 G3 box; other site 1052684015669 G4 box; other site 1052684015670 G5 box; other site 1052684015671 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1052684015672 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1052684015673 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1052684015674 G-X-X-G motif; other site 1052684015675 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1052684015676 RxxxH motif; other site 1052684015677 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1052684015678 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1052684015679 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1052684015680 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1052684015681 Helix-turn-helix; Region: HTH_3; pfam01381 1052684015682 sequence-specific DNA binding site [nucleotide binding]; other site 1052684015683 salt bridge; other site 1052684015684 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1052684015685 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1052684015686 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1052684015687 Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799 1052684015688 DNA binding site [nucleotide binding] 1052684015689 dimer interface [polypeptide binding]; other site 1052684015690 active site 1052684015691 Int/Topo IB signature motif; other site 1052684015692 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1052684015693 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1052684015694 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1052684015695 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 1052684015696 PLD-like domain; Region: PLDc_2; pfam13091 1052684015697 putative active site [active] 1052684015698 catalytic site [active] 1052684015699 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1052684015700 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1052684015701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1052684015702 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684015703 Peptidases of the G1 family and homologs that might lack peptidase activity; Region: Peptidase_G1_like; cl03371 1052684015704 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1052684015705 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1052684015706 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 1052684015707 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1052684015708 putative catalytic site [active] 1052684015709 putative metal binding site [ion binding]; other site 1052684015710 putative phosphate binding site [ion binding]; other site 1052684015711 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 1052684015712 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 1052684015713 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1052684015714 DNA binding residues [nucleotide binding] 1052684015715 dimerization interface [polypeptide binding]; other site 1052684015716 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1052684015717 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1052684015718 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1052684015719 Walker A/P-loop; other site 1052684015720 ATP binding site [chemical binding]; other site 1052684015721 Q-loop/lid; other site 1052684015722 ABC transporter signature motif; other site 1052684015723 Walker B; other site 1052684015724 D-loop; other site 1052684015725 H-loop/switch region; other site 1052684015726 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052684015727 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1052684015728 catalytic residue [active] 1052684015729 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1052684015730 Condensation domain; Region: Condensation; pfam00668 1052684015731 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684015732 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684015733 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684015734 acyl-activating enzyme (AAE) consensus motif; other site 1052684015735 AMP binding site [chemical binding]; other site 1052684015736 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052684015737 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684015738 S-adenosylmethionine binding site [chemical binding]; other site 1052684015739 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052684015740 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684015741 thioester reductase domain; Region: Thioester-redct; TIGR01746 1052684015742 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 1052684015743 putative NAD(P) binding site [chemical binding]; other site 1052684015744 active site 1052684015745 putative substrate binding site [chemical binding]; other site 1052684015746 Condensation domain; Region: Condensation; pfam00668 1052684015747 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684015748 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684015749 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684015750 acyl-activating enzyme (AAE) consensus motif; other site 1052684015751 AMP binding site [chemical binding]; other site 1052684015752 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684015753 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684015754 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052684015755 active site 1052684015756 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052684015757 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1052684015758 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1052684015759 KR domain; Region: KR; pfam08659 1052684015760 NAD(P) binding site [chemical binding]; other site 1052684015761 active site 1052684015762 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684015763 Condensation domain; Region: Condensation; pfam00668 1052684015764 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684015765 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684015766 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684015767 acyl-activating enzyme (AAE) consensus motif; other site 1052684015768 AMP binding site [chemical binding]; other site 1052684015769 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 1052684015770 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052684015771 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684015772 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684015773 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 1052684015774 active site 1052684015775 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1052684015776 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1052684015777 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684015778 Condensation domain; Region: Condensation; pfam00668 1052684015779 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684015780 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684015781 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684015782 acyl-activating enzyme (AAE) consensus motif; other site 1052684015783 AMP binding site [chemical binding]; other site 1052684015784 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684015785 Condensation domain; Region: Condensation; pfam00668 1052684015786 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684015787 Nonribosomal peptide synthase; Region: NRPS; pfam08415 1052684015788 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 1052684015789 acyl-activating enzyme (AAE) consensus motif; other site 1052684015790 AMP binding site [chemical binding]; other site 1052684015791 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684015792 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 1052684015793 putative FMN binding site [chemical binding]; other site 1052684015794 NADPH bind site [chemical binding]; other site 1052684015795 acyl-CoA synthetase; Validated; Region: PRK05850 1052684015796 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1052684015797 acyl-activating enzyme (AAE) consensus motif; other site 1052684015798 active site 1052684015799 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052684015800 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 1052684015801 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 1052684015802 active site 1052684015803 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 1052684015804 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 1052684015805 Condensation domain; Region: Condensation; pfam00668 1052684015806 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 1052684015807 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 1052684015808 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1052684015809 acyl-activating enzyme (AAE) consensus motif; other site 1052684015810 AMP binding site [chemical binding]; other site 1052684015811 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1052684015812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1052684015813 S-adenosylmethionine binding site [chemical binding]; other site 1052684015814 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1052684015815 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1052684015816 RNA polymerase sigma factor; Provisional; Region: PRK12543 1052684015817 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684015818 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684015819 DNA binding residues [nucleotide binding] 1052684015820 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1052684015821 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1052684015822 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1052684015823 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 1052684015824 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 1052684015825 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684015826 Peptidases of the G1 family and homologs that might lack peptidase activity; Region: Peptidase_G1_like; cl03371 1052684015827 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684015828 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 1052684015829 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 1052684015830 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 1052684015831 ATP binding site [chemical binding]; other site 1052684015832 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 1052684015833 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1052684015834 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684015835 non-specific DNA binding site [nucleotide binding]; other site 1052684015836 salt bridge; other site 1052684015837 sequence-specific DNA binding site [nucleotide binding]; other site 1052684015838 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052684015839 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684015840 non-specific DNA binding site [nucleotide binding]; other site 1052684015841 salt bridge; other site 1052684015842 sequence-specific DNA binding site [nucleotide binding]; other site 1052684015843 DNA topoisomerase III; Provisional; Region: PRK07726 1052684015844 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1052684015845 active site 1052684015846 putative interdomain interaction site [polypeptide binding]; other site 1052684015847 putative metal-binding site [ion binding]; other site 1052684015848 putative nucleotide binding site [chemical binding]; other site 1052684015849 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1052684015850 domain I; other site 1052684015851 DNA binding groove [nucleotide binding] 1052684015852 phosphate binding site [ion binding]; other site 1052684015853 domain II; other site 1052684015854 domain III; other site 1052684015855 nucleotide binding site [chemical binding]; other site 1052684015856 catalytic site [active] 1052684015857 domain IV; other site 1052684015858 Ftsk gamma domain; Region: Ftsk_gamma; cl09645 1052684015859 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1052684015860 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 1052684015861 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1052684015862 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1052684015863 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 1052684015864 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684015865 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1052684015866 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1052684015867 Putative serine esterase (DUF676); Region: DUF676; pfam05057 1052684015868 FtsX-like permease family; Region: FtsX; pfam02687 1052684015869 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1052684015870 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1052684015871 Walker A/P-loop; other site 1052684015872 ATP binding site [chemical binding]; other site 1052684015873 Q-loop/lid; other site 1052684015874 ABC transporter signature motif; other site 1052684015875 Walker B; other site 1052684015876 D-loop; other site 1052684015877 H-loop/switch region; other site 1052684015878 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 1052684015879 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684015880 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684015881 DNA binding residues [nucleotide binding] 1052684015882 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052684015883 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1052684015884 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1052684015885 Zn2+ binding site [ion binding]; other site 1052684015886 Mg2+ binding site [ion binding]; other site 1052684015887 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1052684015888 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1052684015889 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1052684015890 metal binding site [ion binding]; metal-binding site 1052684015891 active site 1052684015892 I-site; other site 1052684015893 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684015894 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684015895 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 1052684015896 AAA domain; Region: AAA_31; pfam13614 1052684015897 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1052684015898 AAA domain; Region: AAA_31; pfam13614 1052684015899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684015900 non-specific DNA binding site [nucleotide binding]; other site 1052684015901 salt bridge; other site 1052684015902 sequence-specific DNA binding site [nucleotide binding]; other site 1052684015903 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 1052684015904 Mg binding site [ion binding]; other site 1052684015905 nucleotide binding site [chemical binding]; other site 1052684015906 putative protofilament interface [polypeptide binding]; other site 1052684015907 Replication-relaxation; Region: Replic_Relax; pfam13814 1052684015908 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1052684015909 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052684015910 putative metal binding site [ion binding]; other site 1052684015911 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1052684015912 putative metal binding site [ion binding]; other site 1052684015913 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1052684015914 DNA methylase; Region: N6_N4_Mtase; pfam01555 1052684015915 potential frameshift: common BLAST hit: gi|317134067|ref|YP_004089978.1| DNA methylase N-4/N-6 domain protein 1052684015916 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1052684015917 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1052684015918 DNA methylase; Region: N6_N4_Mtase; cl17433 1052684015919 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 1052684015920 Y_Y_Y domain; Region: Y_Y_Y; pfam07495 1052684015921 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684015922 Interdomain contacts; other site 1052684015923 Cytokine receptor motif; other site 1052684015924 S-layer homology domain; Region: SLH; pfam00395 1052684015925 S-layer homology domain; Region: SLH; pfam00395 1052684015926 S-layer homology domain; Region: SLH; pfam00395 1052684015927 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1052684015928 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1052684015929 Ligand Binding Site [chemical binding]; other site 1052684015930 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1052684015931 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1052684015932 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1052684015933 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1052684015934 Thioredoxin; Region: Thioredoxin_4; pfam13462 1052684015935 Ycf46; Provisional; Region: ycf46; CHL00195 1052684015936 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1052684015937 Walker A motif; other site 1052684015938 ATP binding site [chemical binding]; other site 1052684015939 Walker B motif; other site 1052684015940 arginine finger; other site 1052684015941 Protein of unknown function (DUF1257); Region: DUF1257; cl06088 1052684015942 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 1052684015943 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1052684015944 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1052684015945 FeS/SAM binding site; other site 1052684015946 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1052684015947 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1052684015948 cofactor binding site; other site 1052684015949 DNA binding site [nucleotide binding] 1052684015950 substrate interaction site [chemical binding]; other site 1052684015951 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1052684015952 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1052684015953 Probable transposase; Region: OrfB_IS605; pfam01385 1052684015954 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1052684015955 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 1052684015956 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1052684015957 Ribosomal protein S1 [Translation, ribosomal structure and biogenesis]; Region: RpsA; COG0539 1052684015958 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052684015959 RNA binding site [nucleotide binding]; other site 1052684015960 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164 1052684015961 RNA binding site [nucleotide binding]; other site 1052684015962 DNA primase, catalytic core; Region: dnaG; TIGR01391 1052684015963 CHC2 zinc finger; Region: zf-CHC2; cl17510 1052684015964 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 1052684015965 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1052684015966 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1052684015967 dimer interface [polypeptide binding]; other site 1052684015968 ssDNA binding site [nucleotide binding]; other site 1052684015969 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1052684015970 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1052684015971 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1052684015972 cofactor binding site; other site 1052684015973 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1052684015974 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1052684015975 substrate interaction site [chemical binding]; other site 1052684015976 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 1052684015977 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1052684015978 putative active site [active] 1052684015979 putative NTP binding site [chemical binding]; other site 1052684015980 putative nucleic acid binding site [nucleotide binding]; other site 1052684015981 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1052684015982 active site 1052684015983 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1052684015984 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1052684015985 cofactor binding site; other site 1052684015986 DNA binding site [nucleotide binding] 1052684015987 substrate interaction site [chemical binding]; other site 1052684015988 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 1052684015989 putative DNA binding surface [nucleotide binding]; other site 1052684015990 DNA polymerase III beta subunit; Region: POL3Bc; smart00480 1052684015991 dimer interface [polypeptide binding]; other site 1052684015992 beta-clamp/clamp loader binding surface; other site 1052684015993 beta-clamp/translesion DNA polymerase binding surface; other site 1052684015994 NADH dehydrogenase; Region: NADHdh; cl00469 1052684015995 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 1052684015996 AAA-like domain; Region: AAA_10; pfam12846 1052684015997 Domain of unknown function DUF87; Region: DUF87; pfam01935 1052684015998 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1052684015999 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1052684016000 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1052684016001 catalytic residue [active] 1052684016002 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1052684016003 NlpC/P60 family; Region: NLPC_P60; pfam00877 1052684016004 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1052684016005 DNA/RNA non-specific endonuclease; prokaryotic and eukaryotic double- and single-stranded DNA and RNA endonucleases also present in phosphodiesterases. They exists as monomers and homodimers; Region: NUC; cd00091 1052684016006 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1052684016007 active site 1052684016008 substrate binding site [chemical binding]; other site 1052684016009 Mg2+ binding site [ion binding]; other site 1052684016010 Thioredoxin; Region: Thioredoxin_4; pfam13462 1052684016011 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1052684016012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1052684016013 Coenzyme A binding pocket [chemical binding]; other site 1052684016014 Uncharacterized protein conserved in bacteria (DUF2325); Region: DUF2325; pfam10087 1052684016015 Protein of unknown function DUF262; Region: DUF262; pfam03235 1052684016016 Domain of unknown function (DUF1817); Region: DUF1817; cl02292 1052684016017 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684016018 Interdomain contacts; other site 1052684016019 Cytokine receptor motif; other site 1052684016020 Fibronectin type 3 domain; Region: FN3; smart00060 1052684016021 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684016022 Interdomain contacts; other site 1052684016023 Cytokine receptor motif; other site 1052684016024 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684016025 Interdomain contacts; other site 1052684016026 Cytokine receptor motif; other site 1052684016027 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1052684016028 S-layer homology domain; Region: SLH; pfam00395 1052684016029 S-layer homology domain; Region: SLH; pfam00395 1052684016030 S-layer homology domain; Region: SLH; pfam00395 1052684016031 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 1052684016032 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1052684016033 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 1052684016034 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684016035 non-specific DNA binding site [nucleotide binding]; other site 1052684016036 salt bridge; other site 1052684016037 sequence-specific DNA binding site [nucleotide binding]; other site 1052684016038 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 1052684016039 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 1052684016040 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 1052684016041 active site 1052684016042 DNA binding site [nucleotide binding] 1052684016043 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1052684016044 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 1052684016045 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1052684016046 Restriction endonuclease; Region: Mrr_cat; pfam04471 1052684016047 DNA topoisomerase VI, subunit B [DNA replication, recombination, and repair]; Region: COG1389 1052684016048 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1052684016049 ATP binding site [chemical binding]; other site 1052684016050 Mg2+ binding site [ion binding]; other site 1052684016051 G-X-G motif; other site 1052684016052 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1052684016053 active site 1052684016054 metal binding site [ion binding]; metal-binding site 1052684016055 potential frameshift: common BLAST hit: gi|376266070|ref|YP_005118782.1| Hypothetical protein 1052684016056 Recombination protein U; Region: RecU; cl01314 1052684016057 galactokinase; Provisional; Region: PRK03817 1052684016058 AP2 domain; Region: AP2; pfam00847 1052684016059 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 1052684016060 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1052684016061 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1052684016062 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 1052684016063 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684016064 non-specific DNA binding site [nucleotide binding]; other site 1052684016065 salt bridge; other site 1052684016066 sequence-specific DNA binding site [nucleotide binding]; other site 1052684016067 HTH-like domain; Region: HTH_21; pfam13276 1052684016068 Integrase core domain; Region: rve; pfam00665 1052684016069 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052684016070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684016071 non-specific DNA binding site [nucleotide binding]; other site 1052684016072 salt bridge; other site 1052684016073 sequence-specific DNA binding site [nucleotide binding]; other site 1052684016074 EamA-like transporter family; Region: EamA; pfam00892 1052684016075 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 1052684016076 serine hydroxymethyltransferase; Provisional; Region: PLN03226 1052684016077 PemK-like protein; Region: PemK; pfam02452 1052684016078 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1052684016079 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1052684016080 active site 1052684016081 DNA binding site [nucleotide binding] 1052684016082 Int/Topo IB signature motif; other site 1052684016083 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1052684016084 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 1052684016085 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1052684016086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1052684016087 DNA binding residues [nucleotide binding] 1052684016088 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684016089 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684016090 Uncharacterized proteins similar to Bacillus subtilis YncM; Region: YncM_like; cd13427 1052684016091 putative binding site; other site 1052684016092 putative dimer interface [polypeptide binding]; other site 1052684016093 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1052684016094 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1052684016095 Bacterial SH3 domain; Region: SH3_3; cl17532 1052684016096 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1052684016097 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1052684016098 non-specific DNA binding site [nucleotide binding]; other site 1052684016099 salt bridge; other site 1052684016100 sequence-specific DNA binding site [nucleotide binding]; other site 1052684016101 DNA polymerase IV; Reviewed; Region: PRK03103 1052684016102 Y-family of DNA polymerases; Region: PolY; cl12025 1052684016103 active site 1052684016104 DNA binding site [nucleotide binding] 1052684016105 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1052684016106 YolD-like protein; Region: YolD; pfam08863 1052684016107 Probable transposase; Region: OrfB_IS605; pfam01385 1052684016108 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1052684016109 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 1052684016110 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1052684016111 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1052684016112 Probable transposase; Region: OrfB_IS605; pfam01385 1052684016113 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766