-- dump date 20140619_230017 -- class Genbank::misc_feature -- table misc_feature_note -- id note 886882000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 886882000002 DnaA N-terminal domain; Region: DnaA_N; pfam11638 886882000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882000004 Walker A motif; other site 886882000005 ATP binding site [chemical binding]; other site 886882000006 Walker B motif; other site 886882000007 arginine finger; other site 886882000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 886882000009 DnaA box-binding interface [nucleotide binding]; other site 886882000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 886882000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 886882000012 putative DNA binding surface [nucleotide binding]; other site 886882000013 dimer interface [polypeptide binding]; other site 886882000014 beta-clamp/clamp loader binding surface; other site 886882000015 beta-clamp/translesion DNA polymerase binding surface; other site 886882000016 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 886882000017 RNA binding surface [nucleotide binding]; other site 886882000018 recombination protein F; Reviewed; Region: recF; PRK00064 886882000019 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 886882000020 Walker A/P-loop; other site 886882000021 ATP binding site [chemical binding]; other site 886882000022 Q-loop/lid; other site 886882000023 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882000024 ABC transporter signature motif; other site 886882000025 Walker B; other site 886882000026 D-loop; other site 886882000027 H-loop/switch region; other site 886882000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 886882000029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882000030 Mg2+ binding site [ion binding]; other site 886882000031 G-X-G motif; other site 886882000032 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 886882000033 anchoring element; other site 886882000034 dimer interface [polypeptide binding]; other site 886882000035 ATP binding site [chemical binding]; other site 886882000036 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 886882000037 active site 886882000038 putative metal-binding site [ion binding]; other site 886882000039 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 886882000040 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 886882000041 DNA gyrase subunit A; Validated; Region: PRK05560 886882000042 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 886882000043 CAP-like domain; other site 886882000044 active site 886882000045 primary dimer interface [polypeptide binding]; other site 886882000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 886882000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 886882000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 886882000049 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 886882000050 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 886882000051 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 886882000052 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 886882000053 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882000054 Zn2+ binding site [ion binding]; other site 886882000055 Mg2+ binding site [ion binding]; other site 886882000056 Inhibitor of sigma-G Gin; Region: Gin; pfam10764 886882000057 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 886882000058 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 886882000059 homodimer interface [polypeptide binding]; other site 886882000060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882000061 catalytic residue [active] 886882000062 thymidylate kinase; Validated; Region: tmk; PRK00698 886882000063 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 886882000064 TMP-binding site; other site 886882000065 ATP-binding site [chemical binding]; other site 886882000066 Protein of unknown function (DUF970); Region: DUF970; pfam06153 886882000067 Protein of unknown function (DUF327); Region: DUF327; pfam03885 886882000068 DNA polymerase III subunit delta'; Validated; Region: PRK08058 886882000069 DNA polymerase III subunit delta'; Validated; Region: PRK08485 886882000070 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 886882000071 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 886882000072 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 886882000073 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882000074 S-adenosylmethionine binding site [chemical binding]; other site 886882000075 Predicted methyltransferases [General function prediction only]; Region: COG0313 886882000076 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 886882000077 putative SAM binding site [chemical binding]; other site 886882000078 putative homodimer interface [polypeptide binding]; other site 886882000079 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 886882000080 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 886882000081 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882000082 Zn2+ binding site [ion binding]; other site 886882000083 Mg2+ binding site [ion binding]; other site 886882000084 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 886882000085 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 886882000086 active site 886882000087 Domain of unknown function (DUF348); Region: DUF348; pfam03990 886882000088 Domain of unknown function (DUF348); Region: DUF348; pfam03990 886882000089 G5 domain; Region: G5; pfam07501 886882000090 3D domain; Region: 3D; cl01439 886882000091 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 886882000092 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 886882000093 putative active site [active] 886882000094 putative metal binding site [ion binding]; other site 886882000095 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 886882000096 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 886882000097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882000098 S-adenosylmethionine binding site [chemical binding]; other site 886882000099 YabG peptidase U57; Region: Peptidase_U57; cl05250 886882000100 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 886882000101 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 886882000102 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 886882000103 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 886882000104 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 886882000105 pur operon repressor; Provisional; Region: PRK09213 886882000106 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 886882000107 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 886882000108 active site 886882000109 regulatory protein SpoVG; Reviewed; Region: PRK13259 886882000110 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 886882000111 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 886882000112 Substrate binding site; other site 886882000113 Mg++ binding site; other site 886882000114 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 886882000115 active site 886882000116 substrate binding site [chemical binding]; other site 886882000117 CoA binding site [chemical binding]; other site 886882000118 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 886882000119 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 886882000120 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 886882000121 active site 886882000122 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 886882000123 putative active site [active] 886882000124 catalytic residue [active] 886882000125 Protein of unknown function (DUF2757); Region: DUF2757; pfam10955 886882000126 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 886882000127 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 886882000128 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 886882000129 ATP binding site [chemical binding]; other site 886882000130 putative Mg++ binding site [ion binding]; other site 886882000131 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882000132 nucleotide binding region [chemical binding]; other site 886882000133 ATP-binding site [chemical binding]; other site 886882000134 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 886882000135 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 886882000136 PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616 886882000137 stage V sporulation protein T; Region: spore_V_T; TIGR02851 886882000138 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 886882000139 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 886882000140 Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956 886882000141 N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723 886882000142 putative SAM binding site [chemical binding]; other site 886882000143 putative homodimer interface [polypeptide binding]; other site 886882000144 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 886882000145 homodimer interface [polypeptide binding]; other site 886882000146 metal binding site [ion binding]; metal-binding site 886882000147 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 886882000148 homodimer interface [polypeptide binding]; other site 886882000149 active site 886882000150 putative chemical substrate binding site [chemical binding]; other site 886882000151 metal binding site [ion binding]; metal-binding site 886882000152 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 886882000153 IHF dimer interface [polypeptide binding]; other site 886882000154 IHF - DNA interface [nucleotide binding]; other site 886882000155 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog) [Translation, ribosomal structure and biogenesis]; Region: COG1188 886882000156 YabP family; Region: YabP; cl06766 886882000157 Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; cl09801 886882000158 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 886882000159 Septum formation initiator; Region: DivIC; cl17659 886882000160 hypothetical protein; Provisional; Region: PRK08582 886882000161 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 886882000162 RNA binding site [nucleotide binding]; other site 886882000163 stage II sporulation protein E; Region: spore_II_E; TIGR02865 886882000164 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 886882000165 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 886882000166 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 886882000167 active site 886882000168 ATP binding site [chemical binding]; other site 886882000169 substrate binding site [chemical binding]; other site 886882000170 activation loop (A-loop); other site 886882000171 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 886882000172 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 886882000173 Ligand Binding Site [chemical binding]; other site 886882000174 TilS substrate C-terminal domain; Region: TilS_C; smart00977 886882000175 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 886882000176 active site 886882000177 FtsH Extracellular; Region: FtsH_ext; pfam06480 886882000178 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 886882000179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882000180 Walker A motif; other site 886882000181 ATP binding site [chemical binding]; other site 886882000182 Walker B motif; other site 886882000183 arginine finger; other site 886882000184 Peptidase family M41; Region: Peptidase_M41; pfam01434 886882000185 L-aspartate oxidase; Provisional; Region: PRK06175 886882000186 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 886882000187 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 886882000188 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 886882000189 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 886882000190 dimerization interface [polypeptide binding]; other site 886882000191 active site 886882000192 pantothenate kinase; Reviewed; Region: PRK13318 886882000193 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 886882000194 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 886882000195 dimerization interface [polypeptide binding]; other site 886882000196 domain crossover interface; other site 886882000197 redox-dependent activation switch; other site 886882000198 SurA N-terminal domain; Region: SurA_N_3; cl07813 886882000199 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 886882000200 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 886882000201 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 886882000202 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 886882000203 dimer interface [polypeptide binding]; other site 886882000204 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882000205 catalytic residue [active] 886882000206 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 886882000207 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 886882000208 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 886882000209 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 886882000210 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 886882000211 glutamine binding [chemical binding]; other site 886882000212 catalytic triad [active] 886882000213 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 886882000214 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 886882000215 homodimer interface [polypeptide binding]; other site 886882000216 substrate-cofactor binding pocket; other site 886882000217 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882000218 catalytic residue [active] 886882000219 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 886882000220 dihydropteroate synthase; Region: DHPS; TIGR01496 886882000221 substrate binding pocket [chemical binding]; other site 886882000222 dimer interface [polypeptide binding]; other site 886882000223 inhibitor binding site; inhibition site 886882000224 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 886882000225 homooctamer interface [polypeptide binding]; other site 886882000226 active site 886882000227 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 886882000228 catalytic center binding site [active] 886882000229 ATP binding site [chemical binding]; other site 886882000230 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 886882000231 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882000232 non-specific DNA binding site [nucleotide binding]; other site 886882000233 salt bridge; other site 886882000234 sequence-specific DNA binding site [nucleotide binding]; other site 886882000235 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 886882000236 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 886882000237 FMN binding site [chemical binding]; other site 886882000238 active site 886882000239 catalytic residues [active] 886882000240 substrate binding site [chemical binding]; other site 886882000241 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 886882000242 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 886882000243 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 886882000244 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 886882000245 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 886882000246 dimer interface [polypeptide binding]; other site 886882000247 putative anticodon binding site; other site 886882000248 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 886882000249 motif 1; other site 886882000250 active site 886882000251 motif 2; other site 886882000252 motif 3; other site 886882000253 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 886882000254 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 886882000255 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 886882000256 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 886882000257 NAD binding site [chemical binding]; other site 886882000258 homotetramer interface [polypeptide binding]; other site 886882000259 homodimer interface [polypeptide binding]; other site 886882000260 substrate binding site [chemical binding]; other site 886882000261 active site 886882000262 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 886882000263 AMP-binding enzyme; Region: AMP-binding; pfam00501 886882000264 Adenylate forming domain, Class I; Region: AFD_class_I; cd04433 886882000265 acyl-activating enzyme (AAE) consensus motif; other site 886882000266 acyl-activating enzyme (AAE) consensus motif; other site 886882000267 AMP binding site [chemical binding]; other site 886882000268 active site 886882000269 CoA binding site [chemical binding]; other site 886882000270 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 886882000271 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 886882000272 catalytic residues [active] 886882000273 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 886882000274 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 886882000275 PYR/PP interface [polypeptide binding]; other site 886882000276 dimer interface [polypeptide binding]; other site 886882000277 TPP binding site [chemical binding]; other site 886882000278 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 886882000279 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 886882000280 TPP-binding site [chemical binding]; other site 886882000281 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain; Region: TPP_enzyme_C; pfam02775 886882000282 TPP-binding site [chemical binding]; other site 886882000283 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 886882000284 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 886882000285 dimer interface [polypeptide binding]; other site 886882000286 active site 886882000287 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 886882000288 Condensation domain; Region: Condensation; pfam00668 886882000289 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882000290 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882000291 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882000292 acyl-activating enzyme (AAE) consensus motif; other site 886882000293 AMP binding site [chemical binding]; other site 886882000294 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882000295 peptide synthase; Provisional; Region: PRK12316 886882000296 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882000297 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 886882000298 acyl-activating enzyme (AAE) consensus motif; other site 886882000299 AMP binding site [chemical binding]; other site 886882000300 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882000301 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882000302 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882000303 acyl-activating enzyme (AAE) consensus motif; other site 886882000304 AMP binding site [chemical binding]; other site 886882000305 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882000306 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882000307 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882000308 acyl-activating enzyme (AAE) consensus motif; other site 886882000309 AMP binding site [chemical binding]; other site 886882000310 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882000311 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882000312 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882000313 acyl-activating enzyme (AAE) consensus motif; other site 886882000314 AMP binding site [chemical binding]; other site 886882000315 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882000316 Condensation domain; Region: Condensation; pfam00668 886882000317 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882000318 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882000319 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 886882000320 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882000321 acyl-activating enzyme (AAE) consensus motif; other site 886882000322 AMP binding site [chemical binding]; other site 886882000323 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882000324 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 886882000325 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 886882000326 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 886882000327 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 886882000328 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 886882000329 active site 886882000330 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 886882000331 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 886882000332 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 886882000333 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 886882000334 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 886882000335 active site 886882000336 multimer interface [polypeptide binding]; other site 886882000337 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 886882000338 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 886882000339 predicted active site [active] 886882000340 catalytic triad [active] 886882000341 seryl-tRNA synthetase; Provisional; Region: PRK05431 886882000342 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 886882000343 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 886882000344 dimer interface [polypeptide binding]; other site 886882000345 active site 886882000346 motif 1; other site 886882000347 motif 2; other site 886882000348 motif 3; other site 886882000349 Transposase; Region: HTH_Tnp_1; cl17663 886882000350 putative transposase OrfB; Reviewed; Region: PHA02517 886882000351 HTH-like domain; Region: HTH_21; pfam13276 886882000352 Integrase core domain; Region: rve; pfam00665 886882000353 Integrase core domain; Region: rve_3; pfam13683 886882000354 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 886882000355 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 886882000356 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 886882000357 nucleoside/Zn binding site; other site 886882000358 dimer interface [polypeptide binding]; other site 886882000359 catalytic motif [active] 886882000360 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882000361 dimerization interface [polypeptide binding]; other site 886882000362 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 886882000363 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 886882000364 putative active site [active] 886882000365 heme pocket [chemical binding]; other site 886882000366 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882000367 dimer interface [polypeptide binding]; other site 886882000368 phosphorylation site [posttranslational modification] 886882000369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882000370 ATP binding site [chemical binding]; other site 886882000371 Mg2+ binding site [ion binding]; other site 886882000372 G-X-G motif; other site 886882000373 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 886882000374 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 886882000375 RNA binding surface [nucleotide binding]; other site 886882000376 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 886882000377 probable active site [active] 886882000378 flagellar motor protein MotB; Reviewed; Region: motB; PRK07734 886882000379 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 886882000380 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 886882000381 ligand binding site [chemical binding]; other site 886882000382 flagellar motor protein MotA; Validated; Region: PRK08124 886882000383 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 886882000384 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 886882000385 aromatic arch; other site 886882000386 DCoH dimer interaction site [polypeptide binding]; other site 886882000387 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 886882000388 DCoH tetramer interaction site [polypeptide binding]; other site 886882000389 substrate binding site [chemical binding]; other site 886882000390 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 886882000391 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 886882000392 NlpC/P60 family; Region: NLPC_P60; pfam00877 886882000393 Peptidase M1 family containing bacterial Aminopeptidase N; Region: M1_APN_5; cd09604 886882000394 Zn binding site [ion binding]; other site 886882000395 YwhD family; Region: YwhD; pfam08741 886882000396 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 886882000397 HPr interaction site; other site 886882000398 glycerol kinase (GK) interaction site [polypeptide binding]; other site 886882000399 active site 886882000400 phosphorylation site [posttranslational modification] 886882000401 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 886882000402 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 886882000403 catalytic core [active] 886882000404 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 886882000405 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 886882000406 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 886882000407 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 886882000408 dimer interface [polypeptide binding]; other site 886882000409 Transglycosylase; Region: Transgly; pfam00912 886882000410 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 886882000411 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 886882000412 spermidine synthase; Provisional; Region: PRK00811 886882000413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882000414 H+ Antiporter protein; Region: 2A0121; TIGR00900 886882000415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882000416 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882000417 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882000418 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 886882000419 Walker A/P-loop; other site 886882000420 ATP binding site [chemical binding]; other site 886882000421 Q-loop/lid; other site 886882000422 ABC transporter signature motif; other site 886882000423 Walker B; other site 886882000424 D-loop; other site 886882000425 H-loop/switch region; other site 886882000426 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882000427 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882000428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882000429 Walker A/P-loop; other site 886882000430 ATP binding site [chemical binding]; other site 886882000431 Q-loop/lid; other site 886882000432 ABC transporter signature motif; other site 886882000433 Walker B; other site 886882000434 D-loop; other site 886882000435 H-loop/switch region; other site 886882000436 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882000437 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882000438 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882000439 dimerization interface [polypeptide binding]; other site 886882000440 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 886882000441 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 886882000442 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 886882000443 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 886882000444 active site 886882000445 HIGH motif; other site 886882000446 KMSK motif region; other site 886882000447 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 886882000448 tRNA binding surface [nucleotide binding]; other site 886882000449 anticodon binding site; other site 886882000450 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882000451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882000452 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 886882000453 putative dimerization interface [polypeptide binding]; other site 886882000454 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 886882000455 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882000456 Walker A/P-loop; other site 886882000457 ATP binding site [chemical binding]; other site 886882000458 Q-loop/lid; other site 886882000459 ABC transporter signature motif; other site 886882000460 Walker B; other site 886882000461 D-loop; other site 886882000462 H-loop/switch region; other site 886882000463 TOBE domain; Region: TOBE_2; pfam08402 886882000464 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 886882000465 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 886882000466 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 886882000467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882000468 dimer interface [polypeptide binding]; other site 886882000469 conserved gate region; other site 886882000470 putative PBP binding loops; other site 886882000471 ABC-ATPase subunit interface; other site 886882000472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882000473 dimer interface [polypeptide binding]; other site 886882000474 conserved gate region; other site 886882000475 putative PBP binding loops; other site 886882000476 ABC-ATPase subunit interface; other site 886882000477 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 886882000478 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 886882000479 Beta-Casp domain; Region: Beta-Casp; smart01027 886882000480 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 886882000481 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 886882000482 active site 886882000483 catalytic residues [active] 886882000484 DNA-directed RNA polymerase subunit delta; Reviewed; Region: PRK02363 886882000485 CTP synthetase; Validated; Region: pyrG; PRK05380 886882000486 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 886882000487 Catalytic site [active] 886882000488 active site 886882000489 UTP binding site [chemical binding]; other site 886882000490 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 886882000491 active site 886882000492 putative oxyanion hole; other site 886882000493 catalytic triad [active] 886882000494 Response regulator receiver domain; Region: Response_reg; pfam00072 886882000495 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882000496 active site 886882000497 phosphorylation site [posttranslational modification] 886882000498 intermolecular recognition site; other site 886882000499 dimerization interface [polypeptide binding]; other site 886882000500 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 886882000501 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 886882000502 intersubunit interface [polypeptide binding]; other site 886882000503 active site 886882000504 zinc binding site [ion binding]; other site 886882000505 Na+ binding site [ion binding]; other site 886882000506 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 886882000507 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 886882000508 hinge; other site 886882000509 active site 886882000510 transcription termination factor Rho; Provisional; Region: rho; PRK09376 886882000511 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 886882000512 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 886882000513 RNA binding site [nucleotide binding]; other site 886882000514 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 886882000515 Walker A motif; other site 886882000516 ATP binding site [chemical binding]; other site 886882000517 Walker B motif; other site 886882000518 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882000519 Radical SAM superfamily; Region: Radical_SAM; pfam04055 886882000520 FeS/SAM binding site; other site 886882000521 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 886882000522 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 886882000523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882000524 Walker A motif; other site 886882000525 ATP binding site [chemical binding]; other site 886882000526 Walker B motif; other site 886882000527 arginine finger; other site 886882000528 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 886882000529 hypothetical protein; Validated; Region: PRK00153 886882000530 recombination protein RecR; Reviewed; Region: recR; PRK00076 886882000531 RecR protein; Region: RecR; pfam02132 886882000532 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 886882000533 putative active site [active] 886882000534 putative metal-binding site [ion binding]; other site 886882000535 tetramer interface [polypeptide binding]; other site 886882000536 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 886882000537 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 886882000538 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 886882000539 Walker A/P-loop; other site 886882000540 ATP binding site [chemical binding]; other site 886882000541 Q-loop/lid; other site 886882000542 ABC transporter signature motif; other site 886882000543 Walker B; other site 886882000544 D-loop; other site 886882000545 H-loop/switch region; other site 886882000546 TOBE domain; Region: TOBE; pfam03459 886882000547 HPr kinase/phosphorylase; Provisional; Region: PRK05428 886882000548 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 886882000549 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 886882000550 Hpr binding site; other site 886882000551 active site 886882000552 homohexamer subunit interaction site [polypeptide binding]; other site 886882000553 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 886882000554 pyrophosphatase PpaX; Provisional; Region: PRK13288 886882000555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882000556 active site 886882000557 motif I; other site 886882000558 motif II; other site 886882000559 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 886882000560 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 886882000561 trimer interface [polypeptide binding]; other site 886882000562 active site 886882000563 substrate binding site [chemical binding]; other site 886882000564 CoA binding site [chemical binding]; other site 886882000565 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 886882000566 Acyltransferase family; Region: Acyl_transf_3; pfam01757 886882000567 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12292 886882000568 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 886882000569 dimer interface [polypeptide binding]; other site 886882000570 motif 1; other site 886882000571 active site 886882000572 motif 2; other site 886882000573 motif 3; other site 886882000574 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 886882000575 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 886882000576 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 886882000577 histidinol dehydrogenase; Region: hisD; TIGR00069 886882000578 NAD binding site [chemical binding]; other site 886882000579 dimerization interface [polypeptide binding]; other site 886882000580 product binding site; other site 886882000581 substrate binding site [chemical binding]; other site 886882000582 zinc binding site [ion binding]; other site 886882000583 catalytic residues [active] 886882000584 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 886882000585 putative active site pocket [active] 886882000586 4-fold oligomerization interface [polypeptide binding]; other site 886882000587 metal binding residues [ion binding]; metal-binding site 886882000588 3-fold/trimer interface [polypeptide binding]; other site 886882000589 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 886882000590 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 886882000591 putative active site [active] 886882000592 oxyanion strand; other site 886882000593 catalytic triad [active] 886882000594 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 886882000595 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 886882000596 catalytic residues [active] 886882000597 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 886882000598 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 886882000599 substrate binding site [chemical binding]; other site 886882000600 glutamase interaction surface [polypeptide binding]; other site 886882000601 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 886882000602 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 886882000603 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 886882000604 metal binding site [ion binding]; metal-binding site 886882000605 histidinol-phosphatase; Provisional; Region: PRK07328 886882000606 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 886882000607 active site 886882000608 dimer interface [polypeptide binding]; other site 886882000609 TPR repeat; Region: TPR_11; pfam13414 886882000610 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 886882000611 TPR motif; other site 886882000612 binding surface 886882000613 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 886882000614 TPR motif; other site 886882000615 binding surface 886882000616 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 886882000617 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 886882000618 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882000619 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 886882000620 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 886882000621 nucleotide binding site [chemical binding]; other site 886882000622 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 886882000623 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 886882000624 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 886882000625 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 886882000626 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 886882000627 phosphate binding site [ion binding]; other site 886882000628 putative substrate binding pocket [chemical binding]; other site 886882000629 dimer interface [polypeptide binding]; other site 886882000630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 886882000631 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 886882000632 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 886882000633 dimerization domain swap beta strand [polypeptide binding]; other site 886882000634 regulatory protein interface [polypeptide binding]; other site 886882000635 active site 886882000636 regulatory phosphorylation site [posttranslational modification]; other site 886882000637 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 886882000638 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882000639 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 886882000640 Protein of unknown function (DUF3298); Region: DUF3298; pfam11738 886882000641 Clp protease; Region: CLP_protease; pfam00574 886882000642 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 886882000643 oligomer interface [polypeptide binding]; other site 886882000644 active site residues [active] 886882000645 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 886882000646 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 886882000647 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 886882000648 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 886882000649 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 886882000650 Phosphoglycerate kinase; Region: PGK; pfam00162 886882000651 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 886882000652 substrate binding site [chemical binding]; other site 886882000653 hinge regions; other site 886882000654 ADP binding site [chemical binding]; other site 886882000655 catalytic site [active] 886882000656 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 886882000657 triosephosphate isomerase; Provisional; Region: PRK14565 886882000658 substrate binding site [chemical binding]; other site 886882000659 dimer interface [polypeptide binding]; other site 886882000660 catalytic triad [active] 886882000661 phosphoglyceromutase; Provisional; Region: PRK05434 886882000662 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 886882000663 enolase; Provisional; Region: eno; PRK00077 886882000664 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 886882000665 dimer interface [polypeptide binding]; other site 886882000666 metal binding site [ion binding]; metal-binding site 886882000667 substrate binding pocket [chemical binding]; other site 886882000668 Preprotein translocase SecG subunit; Region: SecG; pfam03840 886882000669 ribonuclease R; Region: RNase_R; TIGR02063 886882000670 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 886882000671 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 886882000672 RNB domain; Region: RNB; pfam00773 886882000673 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 886882000674 RNA binding site [nucleotide binding]; other site 886882000675 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 886882000676 SmpB-tmRNA interface; other site 886882000677 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 886882000678 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 886882000679 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 886882000680 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 886882000681 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 886882000682 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 886882000683 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 886882000684 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 886882000685 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 886882000686 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 886882000687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882000688 FeS/SAM binding site; other site 886882000689 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 886882000690 active site 886882000691 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 886882000692 Ligand Binding Site [chemical binding]; other site 886882000693 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; pfam02592 886882000694 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 886882000695 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 886882000696 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 886882000697 Part of AAA domain; Region: AAA_19; pfam13245 886882000698 Family description; Region: UvrD_C_2; pfam13538 886882000699 hypothetical protein; Reviewed; Region: PRK00024 886882000700 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 886882000701 MPN+ (JAMM) motif; other site 886882000702 Zinc-binding site [ion binding]; other site 886882000703 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882000704 non-specific DNA binding site [nucleotide binding]; other site 886882000705 salt bridge; other site 886882000706 sequence-specific DNA binding site [nucleotide binding]; other site 886882000707 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882000708 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882000709 D5 N terminal like; Region: D5_N; pfam08706 886882000710 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 886882000711 Helix-turn-helix domain; Region: HTH_17; pfam12728 886882000712 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 886882000713 Int/Topo IB signature motif; other site 886882000714 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 886882000715 oligomeric interface; other site 886882000716 putative active site [active] 886882000717 homodimer interface [polypeptide binding]; other site 886882000718 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 886882000719 active site 886882000720 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 886882000721 dimer interface [polypeptide binding]; other site 886882000722 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 886882000723 Ligand Binding Site [chemical binding]; other site 886882000724 Molecular Tunnel; other site 886882000725 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 886882000726 Methyltransferase domain; Region: Methyltransf_23; pfam13489 886882000727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882000728 S-adenosylmethionine binding site [chemical binding]; other site 886882000729 Uncharacterized conserved protein [Function unknown]; Region: COG2850 886882000730 Cupin-like domain; Region: Cupin_8; pfam13621 886882000731 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882000732 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882000733 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882000734 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 886882000735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882000736 Coenzyme A binding pocket [chemical binding]; other site 886882000737 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 886882000738 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 886882000739 P-loop; other site 886882000740 Magnesium ion binding site [ion binding]; other site 886882000741 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 886882000742 Magnesium ion binding site [ion binding]; other site 886882000743 putative transposase OrfB; Reviewed; Region: PHA02517 886882000744 HTH-like domain; Region: HTH_21; pfam13276 886882000745 Integrase core domain; Region: rve; pfam00665 886882000746 Integrase core domain; Region: rve_3; pfam13683 886882000747 Homeodomain-like domain; Region: HTH_23; cl17451 886882000748 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 886882000749 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 886882000750 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 886882000751 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 886882000752 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 886882000753 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 886882000754 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 886882000755 Protein of unknown function, DUF600; Region: DUF600; cl04640 886882000756 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 886882000757 Predicted membrane protein [Function unknown]; Region: COG2259 886882000758 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 886882000759 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 886882000760 Zn binding site [ion binding]; other site 886882000761 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 886882000762 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 886882000763 Zn binding site [ion binding]; other site 886882000764 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 886882000765 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 886882000766 active site 886882000767 N-terminal domain of galactosyltransferase; Region: Glyco_transf_7C; cl17476 886882000768 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882000769 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 886882000770 DNA-binding site [nucleotide binding]; DNA binding site 886882000771 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 886882000772 putative phosphoketolase; Provisional; Region: PRK05261 886882000773 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 886882000774 TPP-binding site; other site 886882000775 XFP C-terminal domain; Region: XFP_C; pfam09363 886882000776 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 886882000777 TFIIB zinc-binding; Region: TF_Zn_Ribbon; pfam08271 886882000778 Repair protein; Region: Repair_PSII; pfam04536 886882000779 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 886882000780 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 886882000781 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 886882000782 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 886882000783 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 886882000784 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 886882000785 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 886882000786 Phytase; Region: Phytase; cl17685 886882000787 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882000788 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882000789 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 886882000790 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 886882000791 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 886882000792 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 886882000793 MATE family multidrug exporter; Provisional; Region: PRK10189 886882000794 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 886882000795 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 886882000796 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 886882000797 NAD(P) binding site [chemical binding]; other site 886882000798 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882000799 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882000800 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 886882000801 putative dimerization interface [polypeptide binding]; other site 886882000802 RDD family; Region: RDD; pfam06271 886882000803 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 886882000804 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 886882000805 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882000806 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882000807 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 886882000808 Domain of unknown function (DUF1963); Region: DUF1963; cl01600 886882000809 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 886882000810 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882000811 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882000812 DNA binding residues [nucleotide binding] 886882000813 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 886882000814 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 886882000815 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 886882000816 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 886882000817 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 886882000818 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 886882000819 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882000820 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882000821 dimer interface [polypeptide binding]; other site 886882000822 conserved gate region; other site 886882000823 putative PBP binding loops; other site 886882000824 ABC-ATPase subunit interface; other site 886882000825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882000826 dimer interface [polypeptide binding]; other site 886882000827 conserved gate region; other site 886882000828 putative PBP binding loops; other site 886882000829 ABC-ATPase subunit interface; other site 886882000830 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882000831 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 886882000832 dimerization interface [polypeptide binding]; other site 886882000833 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 886882000834 Histidine kinase; Region: His_kinase; pfam06580 886882000835 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 886882000836 ATP binding site [chemical binding]; other site 886882000837 Mg2+ binding site [ion binding]; other site 886882000838 G-X-G motif; other site 886882000839 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 886882000840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882000841 active site 886882000842 phosphorylation site [posttranslational modification] 886882000843 intermolecular recognition site; other site 886882000844 dimerization interface [polypeptide binding]; other site 886882000845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882000846 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 886882000847 AAA domain; Region: AAA_18; pfam13238 886882000848 ATP-binding site [chemical binding]; other site 886882000849 Sugar specificity; other site 886882000850 Pyrimidine base specificity; other site 886882000851 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 886882000852 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 886882000853 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882000854 NAD(P) binding site [chemical binding]; other site 886882000855 active site 886882000856 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882000857 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882000858 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882000859 dimerization interface [polypeptide binding]; other site 886882000860 Integrase core domain; Region: rve; pfam00665 886882000861 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882000862 MarR family; Region: MarR; pfam01047 886882000863 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882000864 Coenzyme A binding pocket [chemical binding]; other site 886882000865 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 886882000866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882000867 SNF2 Helicase protein; Region: DUF3670; pfam12419 886882000868 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 886882000869 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 886882000870 ATP binding site [chemical binding]; other site 886882000871 putative Mg++ binding site [ion binding]; other site 886882000872 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882000873 nucleotide binding region [chemical binding]; other site 886882000874 ATP-binding site [chemical binding]; other site 886882000875 SWIM zinc finger; Region: SWIM; pfam04434 886882000876 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 886882000877 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 886882000878 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 886882000879 beta-phosphoglucomutase; Region: bPGM; TIGR01990 886882000880 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882000881 motif II; other site 886882000882 maltose phosphorylase; Provisional; Region: PRK13807 886882000883 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 886882000884 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 886882000885 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 886882000886 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882000887 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882000888 DNA binding site [nucleotide binding] 886882000889 domain linker motif; other site 886882000890 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 886882000891 putative dimerization interface [polypeptide binding]; other site 886882000892 putative ligand binding site [chemical binding]; other site 886882000893 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 886882000894 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882000895 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 886882000896 active site turn [active] 886882000897 phosphorylation site [posttranslational modification] 886882000898 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 886882000899 putative catalytic site [active] 886882000900 putative metal binding site [ion binding]; other site 886882000901 putative phosphate binding site [ion binding]; other site 886882000902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882000903 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882000904 putative substrate translocation pore; other site 886882000905 DinB superfamily; Region: DinB_2; pfam12867 886882000906 hypothetical protein; Provisional; Region: PRK08244 886882000907 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 886882000908 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 886882000909 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882000910 MarR family; Region: MarR; pfam01047 886882000911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882000912 Response regulator receiver domain; Region: Response_reg; pfam00072 886882000913 active site 886882000914 phosphorylation site [posttranslational modification] 886882000915 intermolecular recognition site; other site 886882000916 dimerization interface [polypeptide binding]; other site 886882000917 YcbB domain; Region: YcbB; pfam08664 886882000918 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882000919 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882000920 ATP binding site [chemical binding]; other site 886882000921 Mg2+ binding site [ion binding]; other site 886882000922 G-X-G motif; other site 886882000923 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 886882000924 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 886882000925 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 886882000926 PAS fold; Region: PAS_3; pfam08447 886882000927 putative active site [active] 886882000928 heme pocket [chemical binding]; other site 886882000929 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 886882000930 PAS fold; Region: PAS_3; pfam08447 886882000931 putative active site [active] 886882000932 heme pocket [chemical binding]; other site 886882000933 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882000934 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882000935 dimer interface [polypeptide binding]; other site 886882000936 putative CheW interface [polypeptide binding]; other site 886882000937 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 886882000938 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 886882000939 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882000940 ABC-ATPase subunit interface; other site 886882000941 dimer interface [polypeptide binding]; other site 886882000942 putative PBP binding regions; other site 886882000943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882000944 Coenzyme A binding pocket [chemical binding]; other site 886882000945 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882000946 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882000947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882000948 dimer interface [polypeptide binding]; other site 886882000949 conserved gate region; other site 886882000950 putative PBP binding loops; other site 886882000951 ABC-ATPase subunit interface; other site 886882000952 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882000953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882000954 dimer interface [polypeptide binding]; other site 886882000955 conserved gate region; other site 886882000956 putative PBP binding loops; other site 886882000957 ABC-ATPase subunit interface; other site 886882000958 Cupin domain; Region: Cupin_2; pfam07883 886882000959 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882000960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882000961 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882000962 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 886882000963 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882000964 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 886882000965 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 886882000966 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 886882000967 active site 886882000968 zinc binding site [ion binding]; other site 886882000969 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 886882000970 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 886882000971 NAD binding site [chemical binding]; other site 886882000972 substrate binding site [chemical binding]; other site 886882000973 catalytic Zn binding site [ion binding]; other site 886882000974 tetramer interface [polypeptide binding]; other site 886882000975 structural Zn binding site [ion binding]; other site 886882000976 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882000977 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 886882000978 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 886882000979 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882000980 putative substrate translocation pore; other site 886882000981 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 886882000982 active site 886882000983 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 886882000984 catalytic tetrad [active] 886882000985 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882000986 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882000987 DNA binding site [nucleotide binding] 886882000988 domain linker motif; other site 886882000989 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 886882000990 dimerization interface [polypeptide binding]; other site 886882000991 ligand binding site [chemical binding]; other site 886882000992 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 886882000993 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 886882000994 substrate binding [chemical binding]; other site 886882000995 active site 886882000996 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 886882000997 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 886882000998 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 886882000999 active site turn [active] 886882001000 phosphorylation site [posttranslational modification] 886882001001 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882001002 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882001003 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882001004 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882001005 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 886882001006 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 886882001007 domain interfaces; other site 886882001008 active site 886882001009 Protein of unknown function (DUF805); Region: DUF805; pfam05656 886882001010 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 886882001011 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 886882001012 substrate binding site [chemical binding]; other site 886882001013 active site 886882001014 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 886882001015 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 886882001016 DNA-binding site [nucleotide binding]; DNA binding site 886882001017 RNA-binding motif; other site 886882001018 Cold-inducible protein YdjO; Region: YdjO; pfam14169 886882001019 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 886882001020 Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454 886882001021 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882001022 Coenzyme A binding pocket [chemical binding]; other site 886882001023 Predicted transcriptional regulators [Transcription]; Region: COG1725 886882001024 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882001025 DNA-binding site [nucleotide binding]; DNA binding site 886882001026 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 886882001027 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 886882001028 Walker A/P-loop; other site 886882001029 ATP binding site [chemical binding]; other site 886882001030 Q-loop/lid; other site 886882001031 ABC transporter signature motif; other site 886882001032 Walker B; other site 886882001033 D-loop; other site 886882001034 H-loop/switch region; other site 886882001035 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 886882001036 Protein of unknown function (DUF1453); Region: DUF1453; cl02009 886882001037 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882001038 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 886882001039 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 886882001040 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882001041 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882001042 DNA binding site [nucleotide binding] 886882001043 domain linker motif; other site 886882001044 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 886882001045 dimerization interface [polypeptide binding]; other site 886882001046 ligand binding site [chemical binding]; other site 886882001047 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 886882001048 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 886882001049 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 886882001050 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 886882001051 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882001052 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882001053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001054 dimer interface [polypeptide binding]; other site 886882001055 conserved gate region; other site 886882001056 putative PBP binding loops; other site 886882001057 ABC-ATPase subunit interface; other site 886882001058 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882001059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001060 dimer interface [polypeptide binding]; other site 886882001061 conserved gate region; other site 886882001062 putative PBP binding loops; other site 886882001063 ABC-ATPase subunit interface; other site 886882001064 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 886882001065 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 886882001066 Walker A/P-loop; other site 886882001067 ATP binding site [chemical binding]; other site 886882001068 Q-loop/lid; other site 886882001069 ABC transporter signature motif; other site 886882001070 Walker B; other site 886882001071 D-loop; other site 886882001072 H-loop/switch region; other site 886882001073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882001074 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 886882001075 Walker A/P-loop; other site 886882001076 ATP binding site [chemical binding]; other site 886882001077 Q-loop/lid; other site 886882001078 ABC transporter signature motif; other site 886882001079 Walker B; other site 886882001080 D-loop; other site 886882001081 H-loop/switch region; other site 886882001082 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 886882001083 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 886882001084 HSP90 family protein; Provisional; Region: PRK14083 886882001085 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882001086 ATP binding site [chemical binding]; other site 886882001087 G-X-G motif; other site 886882001088 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 886882001089 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 886882001090 active site 886882001091 catalytic site [active] 886882001092 metal binding site [ion binding]; metal-binding site 886882001093 dimer interface [polypeptide binding]; other site 886882001094 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882001095 S-adenosylmethionine binding site [chemical binding]; other site 886882001096 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 886882001097 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 886882001098 active site 886882001099 tetramer interface; other site 886882001100 Predicted membrane protein [Function unknown]; Region: COG2246 886882001101 GtrA-like protein; Region: GtrA; pfam04138 886882001102 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 886882001103 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 886882001104 Ligand binding site; other site 886882001105 Putative Catalytic site; other site 886882001106 DXD motif; other site 886882001107 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 886882001108 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 886882001109 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882001110 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882001111 active site 886882001112 phosphorylation site [posttranslational modification] 886882001113 intermolecular recognition site; other site 886882001114 dimerization interface [polypeptide binding]; other site 886882001115 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882001116 DNA binding site [nucleotide binding] 886882001117 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882001118 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882001119 dimerization interface [polypeptide binding]; other site 886882001120 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882001121 dimer interface [polypeptide binding]; other site 886882001122 phosphorylation site [posttranslational modification] 886882001123 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882001124 ATP binding site [chemical binding]; other site 886882001125 Mg2+ binding site [ion binding]; other site 886882001126 G-X-G motif; other site 886882001127 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 886882001128 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 886882001129 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 886882001130 putative active site [active] 886882001131 catalytic triad [active] 886882001132 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 886882001133 PA/protease or protease-like domain interface [polypeptide binding]; other site 886882001134 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 886882001135 S-layer homology domain; Region: SLH; pfam00395 886882001136 S-layer homology domain; Region: SLH; pfam00395 886882001137 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 886882001138 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 886882001139 DHHA2 domain; Region: DHHA2; pfam02833 886882001140 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 886882001141 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 886882001142 substrate binding pocket [chemical binding]; other site 886882001143 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 886882001144 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882001145 MarR family; Region: MarR; pfam01047 886882001146 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 886882001147 DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779 886882001148 active site 886882001149 DNA binding site [nucleotide binding] 886882001150 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 886882001151 DNA binding site [nucleotide binding] 886882001152 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882001153 Coenzyme A binding pocket [chemical binding]; other site 886882001154 Predicted membrane protein [Function unknown]; Region: COG2322 886882001155 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882001156 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882001157 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882001158 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001159 dimer interface [polypeptide binding]; other site 886882001160 conserved gate region; other site 886882001161 putative PBP binding loops; other site 886882001162 ABC-ATPase subunit interface; other site 886882001163 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882001164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001165 dimer interface [polypeptide binding]; other site 886882001166 conserved gate region; other site 886882001167 putative PBP binding loops; other site 886882001168 ABC-ATPase subunit interface; other site 886882001169 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 886882001170 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 886882001171 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 886882001172 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 886882001173 putative active site cavity [active] 886882001174 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 886882001175 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 886882001176 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 886882001177 putative active site [active] 886882001178 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 886882001179 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 886882001180 nucleotide binding site [chemical binding]; other site 886882001181 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 886882001182 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 886882001183 PAS domain; Region: PAS_9; pfam13426 886882001184 putative active site [active] 886882001185 heme pocket [chemical binding]; other site 886882001186 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 886882001187 Histidine kinase; Region: HisKA_3; pfam07730 886882001188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882001189 ATP binding site [chemical binding]; other site 886882001190 Mg2+ binding site [ion binding]; other site 886882001191 G-X-G motif; other site 886882001192 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 886882001193 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882001194 active site 886882001195 phosphorylation site [posttranslational modification] 886882001196 intermolecular recognition site; other site 886882001197 dimerization interface [polypeptide binding]; other site 886882001198 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 886882001199 DNA binding residues [nucleotide binding] 886882001200 dimerization interface [polypeptide binding]; other site 886882001201 GAF domain; Region: GAF; pfam01590 886882001202 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 886882001203 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 886882001204 ligand binding site [chemical binding]; other site 886882001205 flexible hinge region; other site 886882001206 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 886882001207 putative switch regulator; other site 886882001208 non-specific DNA interactions [nucleotide binding]; other site 886882001209 DNA binding site [nucleotide binding] 886882001210 sequence specific DNA binding site [nucleotide binding]; other site 886882001211 putative cAMP binding site [chemical binding]; other site 886882001212 A domain family that is part of the cupin metalloenzyme superfamily; Region: JmjC; smart00558 886882001213 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882001214 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882001215 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 886882001216 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001217 conserved gate region; other site 886882001218 dimer interface [polypeptide binding]; other site 886882001219 putative PBP binding loops; other site 886882001220 ABC-ATPase subunit interface; other site 886882001221 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882001222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001223 dimer interface [polypeptide binding]; other site 886882001224 conserved gate region; other site 886882001225 putative PBP binding loops; other site 886882001226 ABC-ATPase subunit interface; other site 886882001227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882001228 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882001229 dimerization interface [polypeptide binding]; other site 886882001230 Histidine kinase; Region: His_kinase; pfam06580 886882001231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882001232 ATP binding site [chemical binding]; other site 886882001233 Mg2+ binding site [ion binding]; other site 886882001234 G-X-G motif; other site 886882001235 Response regulator receiver domain; Region: Response_reg; pfam00072 886882001236 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882001237 active site 886882001238 phosphorylation site [posttranslational modification] 886882001239 intermolecular recognition site; other site 886882001240 dimerization interface [polypeptide binding]; other site 886882001241 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882001242 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882001243 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882001244 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882001245 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882001246 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882001247 dimerization interface [polypeptide binding]; other site 886882001248 aromatic acid decarboxylase; Validated; Region: PRK05920 886882001249 Flavoprotein; Region: Flavoprotein; pfam02441 886882001250 UbiD family decarboxylase; Region: TIGR00148 886882001251 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 886882001252 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 886882001253 Beta-lactamase; Region: Beta-lactamase; pfam00144 886882001254 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 886882001255 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 886882001256 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 886882001257 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 886882001258 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 886882001259 ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879 886882001260 L-serine binding site [chemical binding]; other site 886882001261 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 886882001262 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 886882001263 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 886882001264 Walker A/P-loop; other site 886882001265 ATP binding site [chemical binding]; other site 886882001266 Q-loop/lid; other site 886882001267 ABC transporter signature motif; other site 886882001268 Walker B; other site 886882001269 D-loop; other site 886882001270 H-loop/switch region; other site 886882001271 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 886882001272 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 886882001273 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 886882001274 Walker A/P-loop; other site 886882001275 ATP binding site [chemical binding]; other site 886882001276 Q-loop/lid; other site 886882001277 ABC transporter signature motif; other site 886882001278 Walker B; other site 886882001279 D-loop; other site 886882001280 H-loop/switch region; other site 886882001281 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 886882001282 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 886882001283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001284 dimer interface [polypeptide binding]; other site 886882001285 conserved gate region; other site 886882001286 putative PBP binding loops; other site 886882001287 ABC-ATPase subunit interface; other site 886882001288 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 886882001289 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001290 dimer interface [polypeptide binding]; other site 886882001291 conserved gate region; other site 886882001292 putative PBP binding loops; other site 886882001293 ABC-ATPase subunit interface; other site 886882001294 The substrate binding component of an ABC-type lactococcal OppA-like transport system contains; Region: PBP2_Lactococcal_OppA_like; cd08510 886882001295 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 886882001296 peptide binding site [polypeptide binding]; other site 886882001297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882001298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882001299 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882001300 dimerization interface [polypeptide binding]; other site 886882001301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001302 dimer interface [polypeptide binding]; other site 886882001303 conserved gate region; other site 886882001304 putative PBP binding loops; other site 886882001305 ABC-ATPase subunit interface; other site 886882001306 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 886882001307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001308 dimer interface [polypeptide binding]; other site 886882001309 conserved gate region; other site 886882001310 putative PBP binding loops; other site 886882001311 ABC-ATPase subunit interface; other site 886882001312 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 886882001313 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 886882001314 substrate binding pocket [chemical binding]; other site 886882001315 membrane-bound complex binding site; other site 886882001316 hinge residues; other site 886882001317 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 886882001318 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 886882001319 Walker A/P-loop; other site 886882001320 ATP binding site [chemical binding]; other site 886882001321 Q-loop/lid; other site 886882001322 ABC transporter signature motif; other site 886882001323 Walker B; other site 886882001324 D-loop; other site 886882001325 H-loop/switch region; other site 886882001326 Cupin superfamily (DUF985); Region: Cupin_5; cl01418 886882001327 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 886882001328 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 886882001329 metal binding site [ion binding]; metal-binding site 886882001330 active site 886882001331 I-site; other site 886882001332 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd06166 886882001333 active site 886882001334 catalytic site [active] 886882001335 Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932 886882001336 Collagen binding domain; Region: Collagen_bind; pfam05737 886882001337 Collagen binding domain; Region: Collagen_bind; pfam05737 886882001338 Collagen binding domain; Region: Collagen_bind; pfam05737 886882001339 Collagen binding domain; Region: Collagen_bind; pfam05737 886882001340 Cna protein B-type domain; Region: Cna_B; pfam05738 886882001341 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 886882001342 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 886882001343 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 886882001344 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882001345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882001346 Protein of unknown function (DUF445); Region: DUF445; pfam04286 886882001347 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 886882001348 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 886882001349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882001350 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882001351 dimer interface [polypeptide binding]; other site 886882001352 phosphorylation site [posttranslational modification] 886882001353 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882001354 ATP binding site [chemical binding]; other site 886882001355 Mg2+ binding site [ion binding]; other site 886882001356 G-X-G motif; other site 886882001357 Response regulator receiver domain; Region: Response_reg; pfam00072 886882001358 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882001359 active site 886882001360 phosphorylation site [posttranslational modification] 886882001361 intermolecular recognition site; other site 886882001362 dimerization interface [polypeptide binding]; other site 886882001363 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 886882001364 Histidine kinase; Region: His_kinase; pfam06580 886882001365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882001366 ATP binding site [chemical binding]; other site 886882001367 Mg2+ binding site [ion binding]; other site 886882001368 G-X-G motif; other site 886882001369 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 886882001370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882001371 active site 886882001372 phosphorylation site [posttranslational modification] 886882001373 intermolecular recognition site; other site 886882001374 dimerization interface [polypeptide binding]; other site 886882001375 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 886882001376 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 886882001377 dimer interface [polypeptide binding]; other site 886882001378 FMN binding site [chemical binding]; other site 886882001379 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882001380 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 886882001381 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882001382 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 886882001383 active site 886882001384 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 886882001385 Reeler-like domain of YcnI and similar proteins; Region: YcnI_like; cd08545 886882001386 CopC domain; Region: CopC; pfam04234 886882001387 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 886882001388 YtkA-like; Region: YtkA; pfam13115 886882001389 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 886882001390 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 886882001391 metal binding site [ion binding]; metal-binding site 886882001392 active site 886882001393 I-site; other site 886882001394 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 886882001395 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882001396 Zn2+ binding site [ion binding]; other site 886882001397 Mg2+ binding site [ion binding]; other site 886882001398 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 886882001399 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882001400 putative substrate translocation pore; other site 886882001401 RNA polymerase sigma factor; Provisional; Region: PRK12543 886882001402 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882001403 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882001404 DNA binding residues [nucleotide binding] 886882001405 Domain of unknown function (DUF3600); Region: DUF3600; pfam12207 886882001406 Staphylococcus aureus copper-sensitive operon repressor (CsoR), and related domains; this family was previously known as part of DUF156; Region: SaCsoR-like_DUF156; cd10152 886882001407 putative homodimer interface [polypeptide binding]; other site 886882001408 putative homotetramer interface [polypeptide binding]; other site 886882001409 allosteric switch controlling residues; other site 886882001410 putative metal binding site [ion binding]; other site 886882001411 putative homodimer-homodimer interface [polypeptide binding]; other site 886882001412 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 886882001413 metal-binding site [ion binding] 886882001414 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 886882001415 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 886882001416 metal-binding site [ion binding] 886882001417 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 886882001418 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 886882001419 metal-binding site [ion binding] 886882001420 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 886882001421 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 886882001422 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 886882001423 dimer interface [polypeptide binding]; other site 886882001424 FMN binding site [chemical binding]; other site 886882001425 NADPH bind site [chemical binding]; other site 886882001426 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 886882001427 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 886882001428 active site 886882001429 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 886882001430 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 886882001431 Walker A/P-loop; other site 886882001432 ATP binding site [chemical binding]; other site 886882001433 Q-loop/lid; other site 886882001434 ABC transporter signature motif; other site 886882001435 Walker B; other site 886882001436 D-loop; other site 886882001437 H-loop/switch region; other site 886882001438 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 886882001439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001440 dimer interface [polypeptide binding]; other site 886882001441 conserved gate region; other site 886882001442 putative PBP binding loops; other site 886882001443 ABC-ATPase subunit interface; other site 886882001444 Domain of unknown function DUF77; Region: DUF77; pfam01910 886882001445 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 886882001446 NMT1/THI5 like; Region: NMT1; pfam09084 886882001447 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 886882001448 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 886882001449 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 886882001450 active site 886882001451 metal binding site [ion binding]; metal-binding site 886882001452 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 886882001453 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 886882001454 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 886882001455 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 886882001456 Ca binding site [ion binding]; other site 886882001457 active site 886882001458 catalytic site [active] 886882001459 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 886882001460 Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948 886882001461 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 886882001462 NodB motif; other site 886882001463 active site 886882001464 catalytic site [active] 886882001465 Cd binding site [ion binding]; other site 886882001466 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 886882001467 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 886882001468 Walker A/P-loop; other site 886882001469 ATP binding site [chemical binding]; other site 886882001470 Q-loop/lid; other site 886882001471 ABC transporter signature motif; other site 886882001472 Walker B; other site 886882001473 D-loop; other site 886882001474 H-loop/switch region; other site 886882001475 NIL domain; Region: NIL; pfam09383 886882001476 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001477 ABC-ATPase subunit interface; other site 886882001478 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 886882001479 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 886882001480 active site 886882001481 catalytic tetrad [active] 886882001482 S-layer homology domain; Region: SLH; pfam00395 886882001483 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 886882001484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882001485 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882001486 dimer interface [polypeptide binding]; other site 886882001487 phosphorylation site [posttranslational modification] 886882001488 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882001489 ATP binding site [chemical binding]; other site 886882001490 Mg2+ binding site [ion binding]; other site 886882001491 G-X-G motif; other site 886882001492 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 886882001493 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882001494 active site 886882001495 phosphorylation site [posttranslational modification] 886882001496 intermolecular recognition site; other site 886882001497 dimerization interface [polypeptide binding]; other site 886882001498 Histidine kinase; Region: His_kinase; pfam06580 886882001499 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882001500 ATP binding site [chemical binding]; other site 886882001501 Mg2+ binding site [ion binding]; other site 886882001502 G-X-G motif; other site 886882001503 Response regulator containing CheY-like receiver and SARP domains [Signal transduction mechanisms]; Region: COG3947 886882001504 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882001505 active site 886882001506 phosphorylation site [posttranslational modification] 886882001507 intermolecular recognition site; other site 886882001508 dimerization interface [polypeptide binding]; other site 886882001509 DNA binding site [nucleotide binding] 886882001510 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 886882001511 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 886882001512 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 886882001513 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 886882001514 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 886882001515 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 886882001516 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882001517 Walker A motif; other site 886882001518 ATP binding site [chemical binding]; other site 886882001519 Walker B motif; other site 886882001520 arginine finger; other site 886882001521 Transcriptional antiterminator [Transcription]; Region: COG3933 886882001522 PRD domain; Region: PRD; pfam00874 886882001523 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 886882001524 active pocket/dimerization site; other site 886882001525 active site 886882001526 phosphorylation site [posttranslational modification] 886882001527 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 886882001528 active pocket/dimerization site; other site 886882001529 active site 886882001530 phosphorylation site [posttranslational modification] 886882001531 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 886882001532 active site 886882001533 phosphorylation site [posttranslational modification] 886882001534 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 886882001535 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; cl01507 886882001536 maltodextrin glucosidase; Provisional; Region: PRK10785 886882001537 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 886882001538 homodimer interface [polypeptide binding]; other site 886882001539 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 886882001540 active site 886882001541 homodimer interface [polypeptide binding]; other site 886882001542 catalytic site [active] 886882001543 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 886882001544 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882001545 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882001546 active site 886882001547 phosphorylation site [posttranslational modification] 886882001548 intermolecular recognition site; other site 886882001549 dimerization interface [polypeptide binding]; other site 886882001550 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882001551 DNA binding site [nucleotide binding] 886882001552 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882001553 HAMP domain; Region: HAMP; pfam00672 886882001554 dimerization interface [polypeptide binding]; other site 886882001555 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882001556 dimer interface [polypeptide binding]; other site 886882001557 phosphorylation site [posttranslational modification] 886882001558 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882001559 ATP binding site [chemical binding]; other site 886882001560 Mg2+ binding site [ion binding]; other site 886882001561 G-X-G motif; other site 886882001562 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 886882001563 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 886882001564 Walker A/P-loop; other site 886882001565 ATP binding site [chemical binding]; other site 886882001566 Q-loop/lid; other site 886882001567 ABC transporter signature motif; other site 886882001568 Walker B; other site 886882001569 D-loop; other site 886882001570 H-loop/switch region; other site 886882001571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 886882001572 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 886882001573 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 886882001574 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 886882001575 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 886882001576 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 886882001577 tetramer (dimer of dimers) interface [polypeptide binding]; other site 886882001578 NAD binding site [chemical binding]; other site 886882001579 dimer interface [polypeptide binding]; other site 886882001580 substrate binding site [chemical binding]; other site 886882001581 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 886882001582 DNA binding residues [nucleotide binding] 886882001583 Protein kinase domain; Region: Pkinase; pfam00069 886882001584 Catalytic domain of Protein Kinases; Region: PKc; cd00180 886882001585 active site 886882001586 ATP binding site [chemical binding]; other site 886882001587 substrate binding site [chemical binding]; other site 886882001588 activation loop (A-loop); other site 886882001589 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 886882001590 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 886882001591 N- and C-terminal domain interface [polypeptide binding]; other site 886882001592 active site 886882001593 catalytic site [active] 886882001594 metal binding site [ion binding]; metal-binding site 886882001595 carbohydrate binding site [chemical binding]; other site 886882001596 ATP binding site [chemical binding]; other site 886882001597 Transcriptional regulators [Transcription]; Region: GntR; COG1802 886882001598 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882001599 DNA-binding site [nucleotide binding]; DNA binding site 886882001600 FCD domain; Region: FCD; pfam07729 886882001601 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 886882001602 active site 886882001603 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 886882001604 Protein of unknown function (DUF1453); Region: DUF1453; pfam07301 886882001605 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 886882001606 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 886882001607 dimer interface [polypeptide binding]; other site 886882001608 FMN binding site [chemical binding]; other site 886882001609 Predicted integral membrane protein [Function unknown]; Region: COG0392 886882001610 Uncharacterized conserved protein [Function unknown]; Region: COG2898 886882001611 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 886882001612 Predicted ATPase [General function prediction only]; Region: COG3910 886882001613 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882001614 Walker A/P-loop; other site 886882001615 ATP binding site [chemical binding]; other site 886882001616 Q-loop/lid; other site 886882001617 ABC transporter signature motif; other site 886882001618 Walker B; other site 886882001619 D-loop; other site 886882001620 H-loop/switch region; other site 886882001621 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 886882001622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882001623 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882001624 putative substrate translocation pore; other site 886882001625 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 886882001626 Predicted transcriptional regulator [Transcription]; Region: COG4189 886882001627 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882001628 putative DNA binding site [nucleotide binding]; other site 886882001629 dimerization interface [polypeptide binding]; other site 886882001630 putative Zn2+ binding site [ion binding]; other site 886882001631 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 886882001632 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882001633 Coenzyme A binding pocket [chemical binding]; other site 886882001634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 886882001635 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 886882001636 NADH(P)-binding; Region: NAD_binding_10; pfam13460 886882001637 NAD binding site [chemical binding]; other site 886882001638 putative active site [active] 886882001639 substrate binding site [chemical binding]; other site 886882001640 Uncharacterized conserved protein [Function unknown]; Region: COG0062 886882001641 putative carbohydrate kinase; Provisional; Region: PRK10565 886882001642 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 886882001643 putative substrate binding site [chemical binding]; other site 886882001644 putative ATP binding site [chemical binding]; other site 886882001645 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 886882001646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882001647 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 886882001648 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882001649 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882001650 dimer interface [polypeptide binding]; other site 886882001651 putative CheW interface [polypeptide binding]; other site 886882001652 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 886882001653 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 886882001654 dimer interface [polypeptide binding]; other site 886882001655 putative radical transfer pathway; other site 886882001656 diiron center [ion binding]; other site 886882001657 tyrosyl radical; other site 886882001658 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 886882001659 ATP cone domain; Region: ATP-cone; pfam03477 886882001660 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 886882001661 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 886882001662 Domain of unknown function DUF77; Region: DUF77; pfam01910 886882001663 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 886882001664 DNA binding site [nucleotide binding] 886882001665 active site 886882001666 Int/Topo IB signature motif; other site 886882001667 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 886882001668 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882001669 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 886882001670 short chain dehydrogenase; Provisional; Region: PRK06500 886882001671 classical (c) SDRs; Region: SDR_c; cd05233 886882001672 NAD(P) binding site [chemical binding]; other site 886882001673 active site 886882001674 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882001675 motif II; other site 886882001676 Spore germination protein; Region: Spore_permease; cl17796 886882001677 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 886882001678 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 886882001679 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 886882001680 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 886882001681 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882001682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882001683 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 886882001684 classical (c) SDRs; Region: SDR_c; cd05233 886882001685 NAD(P) binding site [chemical binding]; other site 886882001686 active site 886882001687 fructoselysine 3-epimerase; Provisional; Region: PRK09856 886882001688 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 886882001689 hypothetical protein; Provisional; Region: PHA02764 886882001690 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 886882001691 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 886882001692 putative active site [active] 886882001693 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 886882001694 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 886882001695 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 886882001696 substrate binding site [chemical binding]; other site 886882001697 ATP binding site [chemical binding]; other site 886882001698 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 886882001699 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882001700 DNA-binding site [nucleotide binding]; DNA binding site 886882001701 UTRA domain; Region: UTRA; pfam07702 886882001702 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 886882001703 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 886882001704 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 886882001705 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 886882001706 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 886882001707 Dienelactone hydrolase family; Region: DLH; pfam01738 886882001708 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882001709 dimerization interface [polypeptide binding]; other site 886882001710 putative DNA binding site [nucleotide binding]; other site 886882001711 putative Zn2+ binding site [ion binding]; other site 886882001712 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 886882001713 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK08248 886882001714 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 886882001715 homodimer interface [polypeptide binding]; other site 886882001716 substrate-cofactor binding pocket; other site 886882001717 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882001718 catalytic residue [active] 886882001719 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 886882001720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882001721 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 886882001722 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 886882001723 active site residue [active] 886882001724 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 886882001725 dimer interface [polypeptide binding]; other site 886882001726 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 886882001727 MarR family; Region: MarR_2; pfam12802 886882001728 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 886882001729 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 886882001730 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882001731 dimerization interface [polypeptide binding]; other site 886882001732 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 886882001733 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882001734 Zn2+ binding site [ion binding]; other site 886882001735 Mg2+ binding site [ion binding]; other site 886882001736 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 886882001737 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882001738 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882001739 dimer interface [polypeptide binding]; other site 886882001740 phosphorylation site [posttranslational modification] 886882001741 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882001742 ATP binding site [chemical binding]; other site 886882001743 Mg2+ binding site [ion binding]; other site 886882001744 G-X-G motif; other site 886882001745 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 886882001746 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 886882001747 NAD binding site [chemical binding]; other site 886882001748 active site 886882001749 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 886882001750 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 886882001751 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882001752 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882001753 DNA binding residues [nucleotide binding] 886882001754 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 886882001755 homotrimer interaction site [polypeptide binding]; other site 886882001756 putative active site [active] 886882001757 undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Reviewed; Region: PRK12446 886882001758 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 886882001759 active site 886882001760 homodimer interface [polypeptide binding]; other site 886882001761 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 886882001762 Sodium Bile acid symporter family; Region: SBF; cl17470 886882001763 Sodium Bile acid symporter family; Region: SBF; cl17470 886882001764 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 886882001765 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 886882001766 putative active site [active] 886882001767 putative FMN binding site [chemical binding]; other site 886882001768 putative substrate binding site [chemical binding]; other site 886882001769 putative catalytic residue [active] 886882001770 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 886882001771 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 886882001772 Response regulator receiver domain; Region: Response_reg; pfam00072 886882001773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882001774 active site 886882001775 phosphorylation site [posttranslational modification] 886882001776 intermolecular recognition site; other site 886882001777 dimerization interface [polypeptide binding]; other site 886882001778 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882001779 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882001780 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882001781 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 886882001782 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882001783 dimerization interface [polypeptide binding]; other site 886882001784 Histidine kinase; Region: His_kinase; pfam06580 886882001785 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882001786 ATP binding site [chemical binding]; other site 886882001787 Mg2+ binding site [ion binding]; other site 886882001788 G-X-G motif; other site 886882001789 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882001790 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001791 dimer interface [polypeptide binding]; other site 886882001792 conserved gate region; other site 886882001793 putative PBP binding loops; other site 886882001794 ABC-ATPase subunit interface; other site 886882001795 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882001796 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001797 dimer interface [polypeptide binding]; other site 886882001798 conserved gate region; other site 886882001799 putative PBP binding loops; other site 886882001800 ABC-ATPase subunit interface; other site 886882001801 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882001802 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882001803 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 886882001804 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 886882001805 folate binding site [chemical binding]; other site 886882001806 NADP+ binding site [chemical binding]; other site 886882001807 Predicted transcriptional regulator [Transcription]; Region: COG2378 886882001808 HTH domain; Region: HTH_11; pfam08279 886882001809 WYL domain; Region: WYL; pfam13280 886882001810 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 886882001811 SNF2 Helicase protein; Region: DUF3670; pfam12419 886882001812 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 886882001813 ATP binding site [chemical binding]; other site 886882001814 putative Mg++ binding site [ion binding]; other site 886882001815 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882001816 nucleotide binding region [chemical binding]; other site 886882001817 ATP-binding site [chemical binding]; other site 886882001818 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 886882001819 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 886882001820 Glutathionylspermidine synthase preATP-grasp; Region: GSP_synth; cl00503 886882001821 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 886882001822 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 886882001823 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 886882001824 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882001825 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 886882001826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882001827 putative substrate translocation pore; other site 886882001828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882001829 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882001830 MarR family; Region: MarR_2; pfam12802 886882001831 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882001832 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882001833 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 886882001834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882001835 putative substrate translocation pore; other site 886882001836 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 886882001837 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882001838 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882001839 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 886882001840 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 886882001841 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 886882001842 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 886882001843 active site 886882001844 dimer interface [polypeptide binding]; other site 886882001845 motif 1; other site 886882001846 motif 2; other site 886882001847 motif 3; other site 886882001848 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 886882001849 anticodon binding site; other site 886882001850 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 886882001851 synthetase active site [active] 886882001852 NTP binding site [chemical binding]; other site 886882001853 metal binding site [ion binding]; metal-binding site 886882001854 S-ribosylhomocysteinase; Provisional; Region: PRK02260 886882001855 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 886882001856 classical (c) SDRs; Region: SDR_c; cd05233 886882001857 NAD(P) binding site [chemical binding]; other site 886882001858 active site 886882001859 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 886882001860 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 886882001861 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882001862 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882001863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882001864 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882001865 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 886882001866 Melibiase; Region: Melibiase; pfam02065 886882001867 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 886882001868 Histidine kinase; Region: His_kinase; pfam06580 886882001869 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882001870 ATP binding site [chemical binding]; other site 886882001871 Mg2+ binding site [ion binding]; other site 886882001872 G-X-G motif; other site 886882001873 Response regulator receiver domain; Region: Response_reg; pfam00072 886882001874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882001875 active site 886882001876 phosphorylation site [posttranslational modification] 886882001877 intermolecular recognition site; other site 886882001878 dimerization interface [polypeptide binding]; other site 886882001879 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882001880 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882001881 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882001882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001883 dimer interface [polypeptide binding]; other site 886882001884 conserved gate region; other site 886882001885 putative PBP binding loops; other site 886882001886 ABC-ATPase subunit interface; other site 886882001887 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882001888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882001889 dimer interface [polypeptide binding]; other site 886882001890 conserved gate region; other site 886882001891 ABC-ATPase subunit interface; other site 886882001892 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882001893 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882001894 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 886882001895 Carbohydrate Binding Module 6 (CBM6) domains; many are found in association with discoidin domain(s); Region: CBM6_discoidin-like; cd04083 886882001896 putative metal binding site [ion binding]; other site 886882001897 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 886882001898 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 886882001899 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882001900 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 886882001901 Coenzyme A binding pocket [chemical binding]; other site 886882001902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882001903 NAD(P) binding site [chemical binding]; other site 886882001904 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 886882001905 active site 886882001906 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 886882001907 Part of AAA domain; Region: AAA_19; pfam13245 886882001908 Family description; Region: UvrD_C_2; pfam13538 886882001909 Cold-inducible protein YdjO; Region: YdjO; pfam14169 886882001910 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 886882001911 Predicted transcriptional regulators [Transcription]; Region: COG1378 886882001912 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 886882001913 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 886882001914 C-terminal domain interface [polypeptide binding]; other site 886882001915 sugar binding site [chemical binding]; other site 886882001916 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 886882001917 nudix motif; other site 886882001918 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 886882001919 catalytic core [active] 886882001920 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 886882001921 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 886882001922 Uncharacterized conserved protein [Function unknown]; Region: COG2128 886882001923 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 886882001924 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 886882001925 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882001926 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882001927 DNA binding residues [nucleotide binding] 886882001928 Predicted membrane protein [Function unknown]; Region: COG4818 886882001929 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 886882001930 MOSC domain; Region: MOSC; pfam03473 886882001931 3-alpha domain; Region: 3-alpha; pfam03475 886882001932 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 886882001933 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 886882001934 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 886882001935 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 886882001936 Beta-lactamase; Region: Beta-lactamase; pfam00144 886882001937 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 886882001938 active site 886882001939 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 886882001940 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 886882001941 Uncharacterized conserved protein [Function unknown]; Region: COG2461 886882001942 Family of unknown function (DUF438); Region: DUF438; pfam04282 886882001943 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 886882001944 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 886882001945 Predicted transcriptional regulators [Transcription]; Region: COG1725 886882001946 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882001947 DNA-binding site [nucleotide binding]; DNA binding site 886882001948 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 886882001949 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 886882001950 Walker A/P-loop; other site 886882001951 ATP binding site [chemical binding]; other site 886882001952 Q-loop/lid; other site 886882001953 ABC transporter signature motif; other site 886882001954 Walker B; other site 886882001955 D-loop; other site 886882001956 H-loop/switch region; other site 886882001957 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 886882001958 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882001959 Walker A/P-loop; other site 886882001960 ATP binding site [chemical binding]; other site 886882001961 Q-loop/lid; other site 886882001962 ABC transporter signature motif; other site 886882001963 Walker B; other site 886882001964 D-loop; other site 886882001965 H-loop/switch region; other site 886882001966 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 886882001967 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 886882001968 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882001969 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882001970 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 886882001971 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 886882001972 EVE domain; Region: EVE; cl00728 886882001973 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882001974 Radical SAM superfamily; Region: Radical_SAM; pfam04055 886882001975 FeS/SAM binding site; other site 886882001976 SnoaL-like domain; Region: SnoaL_3; pfam13474 886882001977 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 886882001978 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882001979 Helix-turn-helix domain; Region: HTH_18; pfam12833 886882001980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882001981 recombination factor protein RarA; Reviewed; Region: PRK13342 886882001982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882001983 Walker A motif; other site 886882001984 ATP binding site [chemical binding]; other site 886882001985 Walker B motif; other site 886882001986 arginine finger; other site 886882001987 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 886882001988 Protein of unknown function (DUF419); Region: DUF419; pfam04237 886882001989 YdeM is a Bacillus subtilis protein that belongs to a family of prokaryotic proteins of unkown function. YdeM has sequence similarity to the hot-dog fold of (R)-specific enoyl-CoA hydratase. Other enzymes with this fold include the peroxisomal...; Region: YdeM; cd03454 886882001990 putative active site [active] 886882001991 putative catalytic site [active] 886882001992 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 886882001993 catalytic residue [active] 886882001994 Protein of unknown function, DUF600; Region: DUF600; cl04640 886882001995 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 886882001996 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 886882001997 intersubunit interface [polypeptide binding]; other site 886882001998 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882001999 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882002000 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 886882002001 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 886882002002 intersubunit interface [polypeptide binding]; other site 886882002003 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 886882002004 Sodium Bile acid symporter family; Region: SBF; cl17470 886882002005 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882002006 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882002007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882002008 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 886882002009 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 886882002010 Beta-galactosidase, domain 2; Region: BetaGal_dom2; smart01029 886882002011 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 886882002012 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 886882002013 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 886882002014 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 886882002015 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 886882002016 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 886882002017 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882002018 dimerization interface [polypeptide binding]; other site 886882002019 putative DNA binding site [nucleotide binding]; other site 886882002020 putative Zn2+ binding site [ion binding]; other site 886882002021 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 886882002022 active site residue [active] 886882002023 MarR family; Region: MarR_2; pfam12802 886882002024 OsmC-like protein; Region: OsmC; pfam02566 886882002025 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 886882002026 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 886882002027 E3 interaction surface; other site 886882002028 lipoyl attachment site [posttranslational modification]; other site 886882002029 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 886882002030 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 886882002031 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882002032 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 886882002033 maltose O-acetyltransferase; Provisional; Region: PRK10092 886882002034 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 886882002035 active site 886882002036 substrate binding site [chemical binding]; other site 886882002037 trimer interface [polypeptide binding]; other site 886882002038 CoA binding site [chemical binding]; other site 886882002039 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 886882002040 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882002041 non-specific DNA binding site [nucleotide binding]; other site 886882002042 salt bridge; other site 886882002043 sequence-specific DNA binding site [nucleotide binding]; other site 886882002044 Cupin domain; Region: Cupin_2; pfam07883 886882002045 LysE type translocator; Region: LysE; cl00565 886882002046 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 886882002047 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 886882002048 Ca binding site [ion binding]; other site 886882002049 active site 886882002050 catalytic site [active] 886882002051 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 886882002052 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 886882002053 active site turn [active] 886882002054 phosphorylation site [posttranslational modification] 886882002055 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882002056 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 886882002057 HPr interaction site; other site 886882002058 glycerol kinase (GK) interaction site [polypeptide binding]; other site 886882002059 active site 886882002060 phosphorylation site [posttranslational modification] 886882002061 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882002062 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 886882002063 DNA-binding site [nucleotide binding]; DNA binding site 886882002064 UTRA domain; Region: UTRA; pfam07702 886882002065 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 886882002066 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 886882002067 Spore germination protein; Region: Spore_permease; pfam03845 886882002068 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 886882002069 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 886882002070 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882002071 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 886882002072 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 886882002073 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 886882002074 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 886882002075 iron-sulfur cluster [ion binding]; other site 886882002076 [2Fe-2S] cluster binding site [ion binding]; other site 886882002077 BclB C-terminal domain; Region: exospore_TM; TIGR03721 886882002078 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 886882002079 sugar binding site [chemical binding]; other site 886882002080 S-layer homology domain; Region: SLH; pfam00395 886882002081 S-layer homology domain; Region: SLH; pfam00395 886882002082 S-layer homology domain; Region: SLH; pfam00395 886882002083 Phage Tail Collar Domain; Region: Collar; pfam07484 886882002084 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 886882002085 Spore germination protein; Region: Spore_permease; pfam03845 886882002086 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 886882002087 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 886882002088 Predicted transcriptional regulators [Transcription]; Region: COG1695 886882002089 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 886882002090 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 886882002091 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 886882002092 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882002093 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 886882002094 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 886882002095 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882002096 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882002097 active site 886882002098 phosphorylation site [posttranslational modification] 886882002099 intermolecular recognition site; other site 886882002100 dimerization interface [polypeptide binding]; other site 886882002101 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882002102 DNA binding site [nucleotide binding] 886882002103 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882002104 dimerization interface [polypeptide binding]; other site 886882002105 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882002106 dimer interface [polypeptide binding]; other site 886882002107 phosphorylation site [posttranslational modification] 886882002108 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882002109 ATP binding site [chemical binding]; other site 886882002110 Mg2+ binding site [ion binding]; other site 886882002111 G-X-G motif; other site 886882002112 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 886882002113 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 886882002114 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 886882002115 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 886882002116 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 886882002117 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 886882002118 Predicted flavoprotein [General function prediction only]; Region: COG0431 886882002119 2-dehydropantoate 2-reductase; Provisional; Region: PRK12921 886882002120 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 886882002121 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 886882002122 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 886882002123 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 886882002124 dimer interface [polypeptide binding]; other site 886882002125 FMN binding site [chemical binding]; other site 886882002126 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 886882002127 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 886882002128 Zn binding site [ion binding]; other site 886882002129 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 886882002130 Zn binding site [ion binding]; other site 886882002131 SWIM zinc finger; Region: SWIM; pfam04434 886882002132 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 886882002133 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 886882002134 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 886882002135 ATP binding site [chemical binding]; other site 886882002136 putative Mg++ binding site [ion binding]; other site 886882002137 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882002138 nucleotide binding region [chemical binding]; other site 886882002139 ATP-binding site [chemical binding]; other site 886882002140 Macrolide 2'-Phosphotransferase (MPH2'). MPH2' is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase; Region: MPH2' cd05152 886882002141 Phosphotransferase enzyme family; Region: APH; pfam01636 886882002142 putative active site [active] 886882002143 putative substrate binding site [chemical binding]; other site 886882002144 ATP binding site [chemical binding]; other site 886882002145 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 886882002146 active site 886882002147 putative substrate binding region [chemical binding]; other site 886882002148 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882002149 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882002150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882002151 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 886882002152 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 886882002153 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 886882002154 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 886882002155 HAMP domain; Region: HAMP; pfam00672 886882002156 Histidine kinase; Region: His_kinase; pfam06580 886882002157 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882002158 ATP binding site [chemical binding]; other site 886882002159 Mg2+ binding site [ion binding]; other site 886882002160 G-X-G motif; other site 886882002161 Response regulator receiver domain; Region: Response_reg; pfam00072 886882002162 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882002163 active site 886882002164 phosphorylation site [posttranslational modification] 886882002165 intermolecular recognition site; other site 886882002166 dimerization interface [polypeptide binding]; other site 886882002167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882002168 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882002169 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882002170 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882002171 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882002172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882002173 dimer interface [polypeptide binding]; other site 886882002174 conserved gate region; other site 886882002175 putative PBP binding loops; other site 886882002176 ABC-ATPase subunit interface; other site 886882002177 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882002178 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882002179 dimer interface [polypeptide binding]; other site 886882002180 conserved gate region; other site 886882002181 putative PBP binding loops; other site 886882002182 ABC-ATPase subunit interface; other site 886882002183 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 886882002184 calcium mediated ligand binding site; other site 886882002185 intermolecular salt bridges; other site 886882002186 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 886882002187 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 886882002188 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 886882002189 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 886882002190 Domain of Unknown Function (DUF1259); Region: DUF1529; pfam07485 886882002191 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 886882002192 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882002193 DNA-binding site [nucleotide binding]; DNA binding site 886882002194 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882002195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882002196 homodimer interface [polypeptide binding]; other site 886882002197 catalytic residue [active] 886882002198 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 886882002199 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882002200 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882002201 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 886882002202 helix_turn_helix, mercury resistance; Region: HTH_MERR; smart00422 886882002203 DNA binding residues [nucleotide binding] 886882002204 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 886882002205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882002206 putative substrate translocation pore; other site 886882002207 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 886882002208 Ligand Binding Site [chemical binding]; other site 886882002209 Uncharacterized ALDH (y4uC) with similarity to Tortula ruralis aldehyde dehydrogenase ALDH21A1; Region: ALDH_y4uC; cd07149 886882002210 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 886882002211 NAD(P) binding site [chemical binding]; other site 886882002212 catalytic residues [active] 886882002213 short chain dehydrogenase; Provisional; Region: PRK06523 886882002214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882002215 NAD(P) binding site [chemical binding]; other site 886882002216 active site 886882002217 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 886882002218 SnoaL-like domain; Region: SnoaL_2; pfam12680 886882002219 Predicted transcriptional regulator [Transcription]; Region: COG2378 886882002220 HTH domain; Region: HTH_11; pfam08279 886882002221 WYL domain; Region: WYL; pfam13280 886882002222 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 886882002223 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 886882002224 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 886882002225 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 886882002226 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 886882002227 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 886882002228 DNA binding residues [nucleotide binding] 886882002229 putative dimer interface [polypeptide binding]; other site 886882002230 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 886882002231 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 886882002232 DNA binding residues [nucleotide binding] 886882002233 dimer interface [polypeptide binding]; other site 886882002234 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 886882002235 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 886882002236 GAF domain; Region: GAF_2; pfam13185 886882002237 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 886882002238 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 886882002239 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 886882002240 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 886882002241 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 886882002242 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 886882002243 Walker A/P-loop; other site 886882002244 ATP binding site [chemical binding]; other site 886882002245 Q-loop/lid; other site 886882002246 ABC transporter signature motif; other site 886882002247 Walker B; other site 886882002248 D-loop; other site 886882002249 H-loop/switch region; other site 886882002250 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 886882002251 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 886882002252 Walker A/P-loop; other site 886882002253 ATP binding site [chemical binding]; other site 886882002254 Q-loop/lid; other site 886882002255 ABC transporter signature motif; other site 886882002256 Walker B; other site 886882002257 D-loop; other site 886882002258 H-loop/switch region; other site 886882002259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882002260 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882002261 putative substrate translocation pore; other site 886882002262 Levansucrase/Invertase; Region: Glyco_hydro_68; pfam02435 886882002263 active site 886882002264 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 886882002265 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 886882002266 substrate binding [chemical binding]; other site 886882002267 active site 886882002268 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 886882002269 MarR family; Region: MarR_2; cl17246 886882002270 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882002271 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 886882002272 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 886882002273 LysE type translocator; Region: LysE; cl00565 886882002274 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 886882002275 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 886882002276 putative active site [active] 886882002277 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 886882002278 dimer interface [polypeptide binding]; other site 886882002279 active site 886882002280 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 886882002281 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 886882002282 substrate binding site [chemical binding]; other site 886882002283 ATP binding site [chemical binding]; other site 886882002284 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 886882002285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882002286 DNA-binding site [nucleotide binding]; DNA binding site 886882002287 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 886882002288 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 886882002289 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 886882002290 active site 886882002291 Predicted membrane protein [Function unknown]; Region: COG1288 886882002292 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 886882002293 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 886882002294 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 886882002295 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 886882002296 HI0933-like protein; Region: HI0933_like; pfam03486 886882002297 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 886882002298 PAS fold; Region: PAS_4; pfam08448 886882002299 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882002300 dimer interface [polypeptide binding]; other site 886882002301 phosphorylation site [posttranslational modification] 886882002302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882002303 ATP binding site [chemical binding]; other site 886882002304 Mg2+ binding site [ion binding]; other site 886882002305 G-X-G motif; other site 886882002306 bacillithiol system oxidoreductase, YphP/YqiW family; Region: YphP_YqiW; TIGR04191 886882002307 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 886882002308 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 886882002309 homodimer interface [polypeptide binding]; other site 886882002310 NAD binding pocket [chemical binding]; other site 886882002311 ATP binding pocket [chemical binding]; other site 886882002312 Mg binding site [ion binding]; other site 886882002313 active-site loop [active] 886882002314 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 886882002315 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 886882002316 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 886882002317 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 886882002318 minor groove reading motif; other site 886882002319 helix-hairpin-helix signature motif; other site 886882002320 substrate binding pocket [chemical binding]; other site 886882002321 active site 886882002322 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 886882002323 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 886882002324 DNA binding and oxoG recognition site [nucleotide binding] 886882002325 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 886882002326 Spore germination protein; Region: Spore_permease; cl17796 886882002327 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 886882002328 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882002329 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882002330 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882002331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882002332 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 886882002333 Melibiase; Region: Melibiase; pfam02065 886882002334 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 886882002335 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 886882002336 active site turn [active] 886882002337 phosphorylation site [posttranslational modification] 886882002338 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882002339 DinB family; Region: DinB; cl17821 886882002340 DinB superfamily; Region: DinB_2; pfam12867 886882002341 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 886882002342 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 886882002343 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 886882002344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882002345 Coenzyme A binding pocket [chemical binding]; other site 886882002346 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 886882002347 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 886882002348 Catalytic site [active] 886882002349 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 886882002350 RNA/DNA hybrid binding site [nucleotide binding]; other site 886882002351 active site 886882002352 epoxyqueuosine reductase; Region: TIGR00276 886882002353 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 886882002354 HEAT repeats; Region: HEAT_2; pfam13646 886882002355 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 886882002356 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 886882002357 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 886882002358 DNA binding site [nucleotide binding] 886882002359 active site 886882002360 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 886882002361 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 886882002362 homodecamer interface [polypeptide binding]; other site 886882002363 GTP cyclohydrolase I; Provisional; Region: PLN03044 886882002364 active site 886882002365 putative catalytic site residues [active] 886882002366 zinc binding site [ion binding]; other site 886882002367 GTP-CH-I/GFRP interaction surface; other site 886882002368 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 886882002369 Domain of unknown function (DUF2935); Region: DUF2935; pfam11155 886882002370 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 886882002371 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 886882002372 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 886882002373 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 886882002374 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 886882002375 nucleophilic elbow; other site 886882002376 catalytic triad; other site 886882002377 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 886882002378 Transcriptional regulator [Transcription]; Region: IclR; COG1414 886882002379 Bacterial transcriptional regulator; Region: IclR; pfam01614 886882002380 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 886882002381 ThiC-associated domain; Region: ThiC-associated; pfam13667 886882002382 ThiC family; Region: ThiC; pfam01964 886882002383 Uncharacterized conserved protein [Function unknown]; Region: COG1284 886882002384 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 886882002385 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 886882002386 aconitate hydratase; Validated; Region: PRK09277 886882002387 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 886882002388 substrate binding site [chemical binding]; other site 886882002389 ligand binding site [chemical binding]; other site 886882002390 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 886882002391 substrate binding site [chemical binding]; other site 886882002392 Putative amidase domain; Region: Amidase_6; pfam12671 886882002393 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 886882002394 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 886882002395 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 886882002396 putative UV damage endonuclease; Provisional; Region: uvsE; PRK02308 886882002397 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 886882002398 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 886882002399 active site 886882002400 dimerization interface [polypeptide binding]; other site 886882002401 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882002402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882002403 dimerization interface [polypeptide binding]; other site 886882002404 Histidine kinase; Region: His_kinase; pfam06580 886882002405 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882002406 ATP binding site [chemical binding]; other site 886882002407 Mg2+ binding site [ion binding]; other site 886882002408 G-X-G motif; other site 886882002409 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 886882002410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882002411 active site 886882002412 phosphorylation site [posttranslational modification] 886882002413 intermolecular recognition site; other site 886882002414 dimerization interface [polypeptide binding]; other site 886882002415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882002416 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882002417 PBP superfamily domain; Region: PBP_like_2; cl17296 886882002418 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882002419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882002420 dimer interface [polypeptide binding]; other site 886882002421 conserved gate region; other site 886882002422 putative PBP binding loops; other site 886882002423 ABC-ATPase subunit interface; other site 886882002424 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882002425 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882002426 dimer interface [polypeptide binding]; other site 886882002427 conserved gate region; other site 886882002428 putative PBP binding loops; other site 886882002429 ABC-ATPase subunit interface; other site 886882002430 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 886882002431 active site 886882002432 catalytic triad [active] 886882002433 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 886882002434 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 886882002435 active site 886882002436 zinc binding site [ion binding]; other site 886882002437 Anabaena sensory rhodopsin transducer; Region: ASRT; pfam07100 886882002438 EamA-like transporter family; Region: EamA; pfam00892 886882002439 EamA-like transporter family; Region: EamA; pfam00892 886882002440 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK12389 886882002441 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 886882002442 inhibitor-cofactor binding pocket; inhibition site 886882002443 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882002444 catalytic residue [active] 886882002445 Transcriptional regulator [Transcription]; Region: LytR; COG1316 886882002446 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 886882002447 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 886882002448 Walker A/P-loop; other site 886882002449 ATP binding site [chemical binding]; other site 886882002450 Q-loop/lid; other site 886882002451 ABC transporter signature motif; other site 886882002452 Walker B; other site 886882002453 D-loop; other site 886882002454 H-loop/switch region; other site 886882002455 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 886882002456 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 886882002457 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 886882002458 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 886882002459 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 886882002460 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 886882002461 catalytic triad [active] 886882002462 Spore germination protein; Region: Spore_permease; cl17796 886882002463 Spore germination protein; Region: Spore_permease; cl17796 886882002464 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 886882002465 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 886882002466 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 886882002467 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 886882002468 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 886882002469 GMP synthase; Reviewed; Region: guaA; PRK00074 886882002470 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 886882002471 AMP/PPi binding site [chemical binding]; other site 886882002472 candidate oxyanion hole; other site 886882002473 catalytic triad [active] 886882002474 potential glutamine specificity residues [chemical binding]; other site 886882002475 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 886882002476 ATP Binding subdomain [chemical binding]; other site 886882002477 Ligand Binding sites [chemical binding]; other site 886882002478 Dimerization subdomain; other site 886882002479 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 886882002480 conserved cys residue [active] 886882002481 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 886882002482 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882002483 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882002484 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882002485 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 886882002486 dimerization interface [polypeptide binding]; other site 886882002487 Transcriptional regulators [Transcription]; Region: MarR; COG1846 886882002488 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 886882002489 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 886882002490 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879 886882002491 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 886882002492 dimer interface [polypeptide binding]; other site 886882002493 active site 886882002494 CoA binding pocket [chemical binding]; other site 886882002495 DNA topoisomerase III; Provisional; Region: PRK07726 886882002496 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 886882002497 active site 886882002498 putative interdomain interaction site [polypeptide binding]; other site 886882002499 putative metal-binding site [ion binding]; other site 886882002500 putative nucleotide binding site [chemical binding]; other site 886882002501 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 886882002502 domain I; other site 886882002503 DNA binding groove [nucleotide binding] 886882002504 phosphate binding site [ion binding]; other site 886882002505 domain II; other site 886882002506 domain III; other site 886882002507 nucleotide binding site [chemical binding]; other site 886882002508 catalytic site [active] 886882002509 domain IV; other site 886882002510 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 886882002511 active site 886882002512 homotetramer interface [polypeptide binding]; other site 886882002513 homodimer interface [polypeptide binding]; other site 886882002514 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 886882002515 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 886882002516 Ligand Binding Site [chemical binding]; other site 886882002517 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 886882002518 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 886882002519 ATP-grasp domain; Region: ATP-grasp; pfam02222 886882002520 adenylosuccinate lyase; Provisional; Region: PRK07492 886882002521 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 886882002522 tetramer interface [polypeptide binding]; other site 886882002523 active site 886882002524 Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998 886882002525 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 886882002526 ATP binding site [chemical binding]; other site 886882002527 active site 886882002528 substrate binding site [chemical binding]; other site 886882002529 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 886882002530 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 886882002531 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 886882002532 putative active site [active] 886882002533 catalytic triad [active] 886882002534 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 886882002535 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 886882002536 dimerization interface [polypeptide binding]; other site 886882002537 ATP binding site [chemical binding]; other site 886882002538 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 886882002539 dimerization interface [polypeptide binding]; other site 886882002540 ATP binding site [chemical binding]; other site 886882002541 Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034 886882002542 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 886882002543 active site 886882002544 tetramer interface [polypeptide binding]; other site 886882002545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 886882002546 active site 886882002547 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 886882002548 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 886882002549 dimerization interface [polypeptide binding]; other site 886882002550 putative ATP binding site [chemical binding]; other site 886882002551 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 886882002552 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 886882002553 active site 886882002554 substrate binding site [chemical binding]; other site 886882002555 cosubstrate binding site; other site 886882002556 catalytic site [active] 886882002557 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 886882002558 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 886882002559 purine monophosphate binding site [chemical binding]; other site 886882002560 dimer interface [polypeptide binding]; other site 886882002561 putative catalytic residues [active] 886882002562 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 886882002563 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 886882002564 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 886882002565 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 886882002566 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 886882002567 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882002568 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882002569 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 886882002570 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 886882002571 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 886882002572 substrate binding pocket [chemical binding]; other site 886882002573 membrane-bound complex binding site; other site 886882002574 hinge residues; other site 886882002575 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 886882002576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882002577 dimer interface [polypeptide binding]; other site 886882002578 conserved gate region; other site 886882002579 putative PBP binding loops; other site 886882002580 ABC-ATPase subunit interface; other site 886882002581 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 886882002582 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 886882002583 Walker A/P-loop; other site 886882002584 ATP binding site [chemical binding]; other site 886882002585 Q-loop/lid; other site 886882002586 ABC transporter signature motif; other site 886882002587 Walker B; other site 886882002588 D-loop; other site 886882002589 H-loop/switch region; other site 886882002590 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 886882002591 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 886882002592 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882002593 ABC-ATPase subunit interface; other site 886882002594 dimer interface [polypeptide binding]; other site 886882002595 putative PBP binding regions; other site 886882002596 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 886882002597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882002598 ABC-ATPase subunit interface; other site 886882002599 dimer interface [polypeptide binding]; other site 886882002600 putative PBP binding regions; other site 886882002601 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 886882002602 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 886882002603 siderophore binding site; other site 886882002604 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 886882002605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882002606 active site 886882002607 phosphorylation site [posttranslational modification] 886882002608 intermolecular recognition site; other site 886882002609 dimerization interface [polypeptide binding]; other site 886882002610 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 886882002611 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 886882002612 PAS domain; Region: PAS; smart00091 886882002613 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882002614 ATP binding site [chemical binding]; other site 886882002615 Mg2+ binding site [ion binding]; other site 886882002616 G-X-G motif; other site 886882002617 Uncharacterized conserved protein [Function unknown]; Region: COG1359 886882002618 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 886882002619 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 886882002620 active site 886882002621 catalytic tetrad [active] 886882002622 Predicted integral membrane protein [Function unknown]; Region: COG5658 886882002623 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 886882002624 SdpI/YhfL protein family; Region: SdpI; pfam13630 886882002625 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882002626 dimerization interface [polypeptide binding]; other site 886882002627 putative DNA binding site [nucleotide binding]; other site 886882002628 putative Zn2+ binding site [ion binding]; other site 886882002629 putative hydrolase; Provisional; Region: PRK11460 886882002630 Predicted esterase [General function prediction only]; Region: COG0400 886882002631 small acid-soluble spore protein Tlp; Provisional; Region: PRK03830 886882002632 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882002633 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882002634 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882002635 dimer interface [polypeptide binding]; other site 886882002636 conserved gate region; other site 886882002637 putative PBP binding loops; other site 886882002638 ABC-ATPase subunit interface; other site 886882002639 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882002640 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882002641 dimer interface [polypeptide binding]; other site 886882002642 conserved gate region; other site 886882002643 putative PBP binding loops; other site 886882002644 ABC-ATPase subunit interface; other site 886882002645 threonine dehydratase; Validated; Region: PRK08639 886882002646 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 886882002647 tetramer interface [polypeptide binding]; other site 886882002648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882002649 catalytic residue [active] 886882002650 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 886882002651 putative Ile/Val binding site [chemical binding]; other site 886882002652 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 886882002653 substrate binding site [chemical binding]; other site 886882002654 active site 886882002655 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 886882002656 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882002657 ABC-ATPase subunit interface; other site 886882002658 dimer interface [polypeptide binding]; other site 886882002659 putative PBP binding regions; other site 886882002660 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 886882002661 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882002662 ABC-ATPase subunit interface; other site 886882002663 dimer interface [polypeptide binding]; other site 886882002664 putative PBP binding regions; other site 886882002665 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 886882002666 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 886882002667 intersubunit interface [polypeptide binding]; other site 886882002668 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 886882002669 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 886882002670 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 886882002671 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 886882002672 putative active site [active] 886882002673 metal binding site [ion binding]; metal-binding site 886882002674 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 886882002675 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 886882002676 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 886882002677 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 886882002678 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 886882002679 substrate binding pocket [chemical binding]; other site 886882002680 membrane-bound complex binding site; other site 886882002681 hinge residues; other site 886882002682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882002683 dimer interface [polypeptide binding]; other site 886882002684 conserved gate region; other site 886882002685 putative PBP binding loops; other site 886882002686 ABC-ATPase subunit interface; other site 886882002687 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 886882002688 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 886882002689 Walker A/P-loop; other site 886882002690 ATP binding site [chemical binding]; other site 886882002691 Q-loop/lid; other site 886882002692 ABC transporter signature motif; other site 886882002693 Walker B; other site 886882002694 D-loop; other site 886882002695 H-loop/switch region; other site 886882002696 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 886882002697 Uncharacterized bacterial subfamily of the Thermotoga maritima CorA-like family; Region: TmCorA-like_u2; cd12831 886882002698 oligomer interface [polypeptide binding]; other site 886882002699 metal binding site [ion binding]; metal-binding site 886882002700 metal binding site [ion binding]; metal-binding site 886882002701 putative Cl binding site [ion binding]; other site 886882002702 aspartate ring; other site 886882002703 basic sphincter; other site 886882002704 hydrophobic gate; other site 886882002705 periplasmic entrance; other site 886882002706 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4496 886882002707 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 886882002708 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 886882002709 putative active site [active] 886882002710 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 886882002711 putative active site [active] 886882002712 putative lipid kinase; Reviewed; Region: PRK13337 886882002713 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 886882002714 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 886882002715 23S rRNA (uracil-5-)-methyltransferase RumA; Region: rumA; TIGR00479 886882002716 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882002717 S-adenosylmethionine binding site [chemical binding]; other site 886882002718 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 886882002719 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 886882002720 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 886882002721 FMN binding site [chemical binding]; other site 886882002722 active site 886882002723 catalytic residues [active] 886882002724 substrate binding site [chemical binding]; other site 886882002725 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 886882002726 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882002727 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882002728 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882002729 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882002730 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 886882002731 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 886882002732 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 886882002733 Plasmodium subtelomeric family (PST-A); Region: PST-A; TIGR01607 886882002734 Predicted transcriptional regulator [Transcription]; Region: COG2378 886882002735 HTH domain; Region: HTH_11; pfam08279 886882002736 WYL domain; Region: WYL; pfam13280 886882002737 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 886882002738 dimer interface [polypeptide binding]; other site 886882002739 Uncharacterized conserved protein [Function unknown]; Region: COG0397 886882002740 hypothetical protein; Validated; Region: PRK00029 886882002741 short chain dehydrogenase; Provisional; Region: PRK12747 886882002742 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 886882002743 NADP binding site [chemical binding]; other site 886882002744 homodimer interface [polypeptide binding]; other site 886882002745 active site 886882002746 substrate binding site [chemical binding]; other site 886882002747 putative transport protein YifK; Provisional; Region: PRK10746 886882002748 S-layer homology domain; Region: SLH; pfam00395 886882002749 S-layer homology domain; Region: SLH; pfam00395 886882002750 Domain of Unknown Function with PDB structure (DUF3863); Region: DUF3863; pfam12979 886882002751 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 886882002752 dimer interface [polypeptide binding]; other site 886882002753 FMN binding site [chemical binding]; other site 886882002754 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882002755 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 886882002756 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 886882002757 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 886882002758 intersubunit interface [polypeptide binding]; other site 886882002759 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 886882002760 Phosphotransferase enzyme family; Region: APH; pfam01636 886882002761 active site 886882002762 substrate binding site [chemical binding]; other site 886882002763 ATP binding site [chemical binding]; other site 886882002764 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 886882002765 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 886882002766 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882002767 Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961 886882002768 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 886882002769 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 886882002770 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 886882002771 homodimer interface [polypeptide binding]; other site 886882002772 NADP binding site [chemical binding]; other site 886882002773 substrate binding site [chemical binding]; other site 886882002774 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 886882002775 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 886882002776 putative di-iron ligands [ion binding]; other site 886882002777 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 886882002778 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 886882002779 Histidine kinase; Region: HisKA_3; pfam07730 886882002780 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882002781 ATP binding site [chemical binding]; other site 886882002782 Mg2+ binding site [ion binding]; other site 886882002783 G-X-G motif; other site 886882002784 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 886882002785 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882002786 active site 886882002787 phosphorylation site [posttranslational modification] 886882002788 intermolecular recognition site; other site 886882002789 dimerization interface [polypeptide binding]; other site 886882002790 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 886882002791 DNA binding residues [nucleotide binding] 886882002792 dimerization interface [polypeptide binding]; other site 886882002793 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 886882002794 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 886882002795 Substrate-binding site [chemical binding]; other site 886882002796 Substrate specificity [chemical binding]; other site 886882002797 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 886882002798 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 886882002799 Substrate-binding site [chemical binding]; other site 886882002800 Substrate specificity [chemical binding]; other site 886882002801 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 886882002802 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882002803 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 886882002804 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 886882002805 active site 886882002806 metal binding site [ion binding]; metal-binding site 886882002807 Uncharacterized conserved protein [Function unknown]; Region: RtcB; COG1690 886882002808 shikimate 5-dehydrogenase; Provisional; Region: PRK12548 886882002809 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 886882002810 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 886882002811 shikimate binding site; other site 886882002812 NAD(P) binding site [chemical binding]; other site 886882002813 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882002814 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882002815 putative substrate translocation pore; other site 886882002816 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882002817 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882002818 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 886882002819 putative dimerization interface [polypeptide binding]; other site 886882002820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882002821 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882002822 putative substrate translocation pore; other site 886882002823 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 886882002824 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 886882002825 active site 886882002826 catalytic residue [active] 886882002827 dimer interface [polypeptide binding]; other site 886882002828 shikimate kinase; Reviewed; Region: aroK; PRK00131 886882002829 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 886882002830 ADP binding site [chemical binding]; other site 886882002831 magnesium binding site [ion binding]; other site 886882002832 putative shikimate binding site; other site 886882002833 Pectate lyase; Region: Pectate_lyase; pfam03211 886882002834 Ecdysteroid kinase; Region: EcKinase; cl17738 886882002835 Phosphotransferase enzyme family; Region: APH; pfam01636 886882002836 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 886882002837 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 886882002838 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 886882002839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882002840 putative substrate translocation pore; other site 886882002841 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 886882002842 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 886882002843 dimer interface [polypeptide binding]; other site 886882002844 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882002845 catalytic residue [active] 886882002846 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 886882002847 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 886882002848 active site 886882002849 catalytic tetrad [active] 886882002850 WYL domain; Region: WYL; pfam13280 886882002851 WYL domain; Region: WYL; pfam13280 886882002852 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 886882002853 RNA repair, ligase-Pnkp-associating, region of Hen1; Region: Hen1_L; pfam12623 886882002854 3' terminal RNA ribose 2'-O-methyltransferase Hen1; Region: bacter_Hen1; TIGR04074 886882002855 polynucleotide kinase-phosphatase; Region: bacter_Pnkp; TIGR04075 886882002856 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 886882002857 active site 886882002858 metal binding site [ion binding]; metal-binding site 886882002859 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 886882002860 active site 886882002861 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 886882002862 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 886882002863 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 886882002864 Walker A/P-loop; other site 886882002865 ATP binding site [chemical binding]; other site 886882002866 Q-loop/lid; other site 886882002867 ABC transporter signature motif; other site 886882002868 Walker B; other site 886882002869 D-loop; other site 886882002870 H-loop/switch region; other site 886882002871 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 886882002872 Walker A/P-loop; other site 886882002873 ATP binding site [chemical binding]; other site 886882002874 Q-loop/lid; other site 886882002875 ABC transporter signature motif; other site 886882002876 Walker B; other site 886882002877 D-loop; other site 886882002878 H-loop/switch region; other site 886882002879 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 886882002880 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 886882002881 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 886882002882 Walker A/P-loop; other site 886882002883 ATP binding site [chemical binding]; other site 886882002884 Q-loop/lid; other site 886882002885 ABC transporter signature motif; other site 886882002886 Walker B; other site 886882002887 D-loop; other site 886882002888 H-loop/switch region; other site 886882002889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882002890 dimer interface [polypeptide binding]; other site 886882002891 conserved gate region; other site 886882002892 ABC-ATPase subunit interface; other site 886882002893 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 886882002894 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 886882002895 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 886882002896 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882002897 Coenzyme A binding pocket [chemical binding]; other site 886882002898 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 886882002899 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882002900 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 886882002901 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 886882002902 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 886882002903 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 886882002904 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 886882002905 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 886882002906 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 886882002907 S-layer homology domain; Region: SLH; pfam00395 886882002908 tetracycline repressor protein TetR; Provisional; Region: PRK13756 886882002909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882002910 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 886882002911 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 886882002912 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 886882002913 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918 886882002914 hypothetical protein; Provisional; Region: PRK13660 886882002915 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 886882002916 metal binding site [ion binding]; metal-binding site 886882002917 active site 886882002918 YvrJ protein family; Region: YvrJ; pfam12841 886882002919 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 886882002920 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882002921 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 886882002922 active site 886882002923 motif I; other site 886882002924 motif II; other site 886882002925 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 886882002926 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 886882002927 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 886882002928 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 886882002929 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 886882002930 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 886882002931 acyl-activating enzyme (AAE) consensus motif; other site 886882002932 putative AMP binding site [chemical binding]; other site 886882002933 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882002934 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 886882002935 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 886882002936 active site 886882002937 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882002938 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 886882002939 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 886882002940 inhibitor-cofactor binding pocket; inhibition site 886882002941 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882002942 catalytic residue [active] 886882002943 Condensation domain; Region: Condensation; pfam00668 886882002944 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882002945 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882002946 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 886882002947 CoA binding site [chemical binding]; other site 886882002948 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882002949 Condensation domain; Region: Condensation; pfam00668 886882002950 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882002951 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882002952 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882002953 acyl-activating enzyme (AAE) consensus motif; other site 886882002954 AMP binding site [chemical binding]; other site 886882002955 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882002956 Condensation domain; Region: Condensation; pfam00668 886882002957 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882002958 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882002959 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882002960 acyl-activating enzyme (AAE) consensus motif; other site 886882002961 AMP binding site [chemical binding]; other site 886882002962 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882002963 Condensation domain; Region: Condensation; pfam00668 886882002964 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882002965 Condensation domain; Region: Condensation; pfam00668 886882002966 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882002967 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882002968 acyl-activating enzyme (AAE) consensus motif; other site 886882002969 AMP binding site [chemical binding]; other site 886882002970 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882002971 Condensation domain; Region: Condensation; pfam00668 886882002972 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882002973 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882002974 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882002975 acyl-activating enzyme (AAE) consensus motif; other site 886882002976 AMP binding site [chemical binding]; other site 886882002977 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882002978 Condensation domain; Region: Condensation; pfam00668 886882002979 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882002980 peptide synthase; Provisional; Region: PRK12467 886882002981 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882002982 acyl-activating enzyme (AAE) consensus motif; other site 886882002983 AMP binding site [chemical binding]; other site 886882002984 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882002985 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882002986 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 886882002987 acyl-activating enzyme (AAE) consensus motif; other site 886882002988 AMP binding site [chemical binding]; other site 886882002989 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882002990 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882002991 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882002992 acyl-activating enzyme (AAE) consensus motif; other site 886882002993 AMP binding site [chemical binding]; other site 886882002994 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882002995 Condensation domain; Region: Condensation; pfam00668 886882002996 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882002997 H+ Antiporter protein; Region: 2A0121; TIGR00900 886882002998 putative substrate translocation pore; other site 886882002999 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882003000 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 886882003001 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 886882003002 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 886882003003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882003004 Walker A/P-loop; other site 886882003005 ATP binding site [chemical binding]; other site 886882003006 Q-loop/lid; other site 886882003007 ABC transporter signature motif; other site 886882003008 Walker B; other site 886882003009 D-loop; other site 886882003010 H-loop/switch region; other site 886882003011 7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695 886882003012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 886882003013 Histidine kinase; Region: HisKA_3; pfam07730 886882003014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882003015 ATP binding site [chemical binding]; other site 886882003016 Mg2+ binding site [ion binding]; other site 886882003017 G-X-G motif; other site 886882003018 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 886882003019 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882003020 active site 886882003021 phosphorylation site [posttranslational modification] 886882003022 intermolecular recognition site; other site 886882003023 dimerization interface [polypeptide binding]; other site 886882003024 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 886882003025 DNA binding residues [nucleotide binding] 886882003026 dimerization interface [polypeptide binding]; other site 886882003027 tellurite resistance protein terB; Region: terB; cd07176 886882003028 putative metal binding site [ion binding]; other site 886882003029 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 886882003030 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 886882003031 putative metal binding site [ion binding]; other site 886882003032 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 886882003033 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 886882003034 putative metal binding site [ion binding]; other site 886882003035 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 886882003036 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 886882003037 putative metal binding site [ion binding]; other site 886882003038 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 886882003039 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 886882003040 putative metal binding site [ion binding]; other site 886882003041 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 886882003042 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 886882003043 putative metal binding site [ion binding]; other site 886882003044 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 886882003045 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 886882003046 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 886882003047 active site 886882003048 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 886882003049 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 886882003050 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 886882003051 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 886882003052 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 886882003053 zinc binding site [ion binding]; other site 886882003054 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 886882003055 metal ion-dependent adhesion site (MIDAS); other site 886882003056 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 886882003057 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 886882003058 peptide binding site [polypeptide binding]; other site 886882003059 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 886882003060 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 886882003061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882003062 putative PBP binding loops; other site 886882003063 dimer interface [polypeptide binding]; other site 886882003064 ABC-ATPase subunit interface; other site 886882003065 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 886882003066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882003067 dimer interface [polypeptide binding]; other site 886882003068 conserved gate region; other site 886882003069 putative PBP binding loops; other site 886882003070 ABC-ATPase subunit interface; other site 886882003071 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 886882003072 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 886882003073 substrate binding pocket [chemical binding]; other site 886882003074 membrane-bound complex binding site; other site 886882003075 hinge residues; other site 886882003076 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 886882003077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882003078 dimer interface [polypeptide binding]; other site 886882003079 conserved gate region; other site 886882003080 putative PBP binding loops; other site 886882003081 ABC-ATPase subunit interface; other site 886882003082 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 886882003083 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 886882003084 Walker A/P-loop; other site 886882003085 ATP binding site [chemical binding]; other site 886882003086 Q-loop/lid; other site 886882003087 ABC transporter signature motif; other site 886882003088 Walker B; other site 886882003089 D-loop; other site 886882003090 H-loop/switch region; other site 886882003091 Cupin domain; Region: Cupin_2; pfam07883 886882003092 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882003093 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882003094 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 886882003095 EamA-like transporter family; Region: EamA; pfam00892 886882003096 EamA-like transporter family; Region: EamA; pfam00892 886882003097 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 886882003098 dimer interface [polypeptide binding]; other site 886882003099 putative tRNA-binding site [nucleotide binding]; other site 886882003100 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 886882003101 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882003102 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882003103 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882003104 putative substrate translocation pore; other site 886882003105 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 886882003106 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 886882003107 putative NAD(P) binding site [chemical binding]; other site 886882003108 putative substrate binding site [chemical binding]; other site 886882003109 catalytic Zn binding site [ion binding]; other site 886882003110 structural Zn binding site [ion binding]; other site 886882003111 dimer interface [polypeptide binding]; other site 886882003112 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 886882003113 EamA-like transporter family; Region: EamA; pfam00892 886882003114 EamA-like transporter family; Region: EamA; pfam00892 886882003115 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882003116 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882003117 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882003118 DinB family; Region: DinB; cl17821 886882003119 short chain dehydrogenase; Provisional; Region: PRK07454 886882003120 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 886882003121 NADP binding site [chemical binding]; other site 886882003122 substrate binding site [chemical binding]; other site 886882003123 active site 886882003124 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882003125 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 886882003126 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 886882003127 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 886882003128 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882003129 active site 886882003130 motif I; other site 886882003131 motif II; other site 886882003132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882003133 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882003134 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882003135 DNA binding site [nucleotide binding] 886882003136 domain linker motif; other site 886882003137 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 886882003138 ligand binding site [chemical binding]; other site 886882003139 dimerization interface [polypeptide binding]; other site 886882003140 Erythromycin esterase; Region: Erythro_esteras; pfam05139 886882003141 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 886882003142 calcium mediated ligand binding site; other site 886882003143 intermolecular salt bridges; other site 886882003144 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 886882003145 alpha-galactosidase; Provisional; Region: PRK15076 886882003146 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 886882003147 NAD binding site [chemical binding]; other site 886882003148 sugar binding site [chemical binding]; other site 886882003149 divalent metal binding site [ion binding]; other site 886882003150 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 886882003151 dimer interface [polypeptide binding]; other site 886882003152 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882003153 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 886882003154 RNA polymerase sigma-70 factor, Bacteroides expansion family 1; Region: Sig70_bacteroi1; TIGR02985 886882003155 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882003156 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882003157 DNA binding residues [nucleotide binding] 886882003158 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 886882003159 Rhamnogalacturonan lyase of the polysaccharide lyase family 11; Region: RGL11; cd10318 886882003160 metal binding site [ion binding]; metal-binding site 886882003161 active site 886882003162 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882003163 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882003164 DNA binding site [nucleotide binding] 886882003165 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 886882003166 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882003167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882003168 dimer interface [polypeptide binding]; other site 886882003169 conserved gate region; other site 886882003170 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 886882003171 ABC-ATPase subunit interface; other site 886882003172 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882003173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882003174 dimer interface [polypeptide binding]; other site 886882003175 conserved gate region; other site 886882003176 putative PBP binding loops; other site 886882003177 ABC-ATPase subunit interface; other site 886882003178 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882003179 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882003180 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 886882003181 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 886882003182 substrate binding [chemical binding]; other site 886882003183 active site 886882003184 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 886882003185 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 886882003186 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 886882003187 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 886882003188 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 886882003189 active site 886882003190 substrate binding [chemical binding]; other site 886882003191 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 886882003192 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 886882003193 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 886882003194 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882003195 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882003196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882003197 Walker A/P-loop; other site 886882003198 ATP binding site [chemical binding]; other site 886882003199 Q-loop/lid; other site 886882003200 ABC transporter signature motif; other site 886882003201 Walker B; other site 886882003202 D-loop; other site 886882003203 H-loop/switch region; other site 886882003204 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882003205 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882003206 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 886882003207 Walker A/P-loop; other site 886882003208 ATP binding site [chemical binding]; other site 886882003209 Q-loop/lid; other site 886882003210 ABC transporter signature motif; other site 886882003211 Walker B; other site 886882003212 D-loop; other site 886882003213 H-loop/switch region; other site 886882003214 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882003215 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882003216 putative substrate translocation pore; other site 886882003217 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882003218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882003219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882003220 Cupin domain; Region: Cupin_2; pfam07883 886882003221 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882003222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882003223 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882003224 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 886882003225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882003226 putative substrate translocation pore; other site 886882003227 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 886882003228 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882003229 active site 886882003230 phosphorylation site [posttranslational modification] 886882003231 intermolecular recognition site; other site 886882003232 dimerization interface [polypeptide binding]; other site 886882003233 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882003234 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882003235 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882003236 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882003237 dimerization interface [polypeptide binding]; other site 886882003238 Histidine kinase; Region: His_kinase; pfam06580 886882003239 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882003240 ATP binding site [chemical binding]; other site 886882003241 Mg2+ binding site [ion binding]; other site 886882003242 G-X-G motif; other site 886882003243 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 886882003244 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 886882003245 ligand binding site [chemical binding]; other site 886882003246 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 886882003247 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882003248 active site 886882003249 motif I; other site 886882003250 motif II; other site 886882003251 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882003252 alpha-galactosidase; Provisional; Region: PRK15076 886882003253 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 886882003254 NAD binding site [chemical binding]; other site 886882003255 sugar binding site [chemical binding]; other site 886882003256 divalent metal binding site [ion binding]; other site 886882003257 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 886882003258 dimer interface [polypeptide binding]; other site 886882003259 Cellobiohydrolase A (1,4-beta-cellobiosidase A) [Carbohydrate transport and metabolism]; Region: CelA; COG5297 886882003260 Glycosyl hydrolases family 6; Region: Glyco_hydro_6; pfam01341 886882003261 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882003262 Interdomain contacts; other site 886882003263 Cytokine receptor motif; other site 886882003264 Cellulose binding domain; Region: CBM_3; pfam00942 886882003265 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 886882003266 active site 886882003267 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 886882003268 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 886882003269 putative active site [active] 886882003270 heme pocket [chemical binding]; other site 886882003271 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 886882003272 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 886882003273 putative active site [active] 886882003274 heme pocket [chemical binding]; other site 886882003275 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 886882003276 putative active site [active] 886882003277 heme pocket [chemical binding]; other site 886882003278 PAS domain S-box; Region: sensory_box; TIGR00229 886882003279 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 886882003280 putative active site [active] 886882003281 heme pocket [chemical binding]; other site 886882003282 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 886882003283 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 886882003284 putative active site [active] 886882003285 heme pocket [chemical binding]; other site 886882003286 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882003287 dimer interface [polypeptide binding]; other site 886882003288 phosphorylation site [posttranslational modification] 886882003289 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882003290 ATP binding site [chemical binding]; other site 886882003291 Mg2+ binding site [ion binding]; other site 886882003292 G-X-G motif; other site 886882003293 Predicted transcriptional regulators [Transcription]; Region: COG1725 886882003294 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882003295 DNA-binding site [nucleotide binding]; DNA binding site 886882003296 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 886882003297 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 886882003298 Walker A/P-loop; other site 886882003299 ATP binding site [chemical binding]; other site 886882003300 Q-loop/lid; other site 886882003301 ABC transporter signature motif; other site 886882003302 Walker B; other site 886882003303 D-loop; other site 886882003304 H-loop/switch region; other site 886882003305 Methyltransferase domain; Region: Methyltransf_11; pfam08241 886882003306 PBP superfamily domain; Region: PBP_like_2; cl17296 886882003307 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 886882003308 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 886882003309 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 886882003310 active site 886882003311 catalytic tetrad [active] 886882003312 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 886882003313 active site 886882003314 SUMO-1 interface [polypeptide binding]; other site 886882003315 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 886882003316 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 886882003317 hexamer interface [polypeptide binding]; other site 886882003318 ligand binding site [chemical binding]; other site 886882003319 putative active site [active] 886882003320 NAD(P) binding site [chemical binding]; other site 886882003321 DRTGG domain; Region: DRTGG; pfam07085 886882003322 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 886882003323 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 886882003324 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882003325 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 886882003326 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 886882003327 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 886882003328 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 886882003329 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 886882003330 active site 886882003331 catalytic triad [active] 886882003332 oxyanion hole [active] 886882003333 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 886882003334 Domain of unknown function DUF21; Region: DUF21; pfam01595 886882003335 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 886882003336 Transporter associated domain; Region: CorC_HlyC; smart01091 886882003337 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 886882003338 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882003339 dimerization interface [polypeptide binding]; other site 886882003340 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882003341 dimer interface [polypeptide binding]; other site 886882003342 putative CheW interface [polypeptide binding]; other site 886882003343 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 886882003344 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 886882003345 classical (c) SDRs; Region: SDR_c; cd05233 886882003346 NAD(P) binding site [chemical binding]; other site 886882003347 active site 886882003348 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 886882003349 MgtC family; Region: MgtC; pfam02308 886882003350 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 886882003351 active site 886882003352 Protein of unknown function (DUF3886); Region: DUF3886; pfam13025 886882003353 drug efflux system protein MdtG; Provisional; Region: PRK09874 886882003354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882003355 putative substrate translocation pore; other site 886882003356 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 886882003357 EamA-like transporter family; Region: EamA; pfam00892 886882003358 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 886882003359 EamA-like transporter family; Region: EamA; pfam00892 886882003360 Predicted transcriptional regulators [Transcription]; Region: COG1378 886882003361 Sugar-specific transcriptional regulator TrmB; Region: TrmB; pfam01978 886882003362 Middle phospholipase D-like domain of the transcriptional regulator TrmB and similar proteins; Region: PLDc_like_TrmB_middle; cd09124 886882003363 C-terminal domain interface [polypeptide binding]; other site 886882003364 sugar binding site [chemical binding]; other site 886882003365 bifunctional 3-deoxy-7-phosphoheptulonate synthase/chorismate mutase; Reviewed; Region: PRK12595 886882003366 Chorismate mutase type II; Region: CM_2; cl00693 886882003367 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 886882003368 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882003369 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882003370 dimer interface [polypeptide binding]; other site 886882003371 phosphorylation site [posttranslational modification] 886882003372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882003373 ATP binding site [chemical binding]; other site 886882003374 Mg2+ binding site [ion binding]; other site 886882003375 G-X-G motif; other site 886882003376 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 886882003377 Catalytic NodB homology domain of Streptomyces lividans acetylxylan esterase and its bacterial homologs; Region: CE4_SlAXE_like; cd10953 886882003378 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 886882003379 NodB motif; other site 886882003380 active site 886882003381 catalytic site [active] 886882003382 Zn binding site [ion binding]; other site 886882003383 dimer interface [polypeptide binding]; other site 886882003384 Carbohydrate Binding Module families 36 (CBM36) and 6 (CBM6); appended mainly to glycoside hydrolase family 11 (GH11) domains; xylan binding; Region: CBM6_36_xylanase-like; cd04078 886882003385 Ca binding site [ion binding]; other site 886882003386 Ca binding site (active) [ion binding]; other site 886882003387 ligand binding site [chemical binding]; other site 886882003388 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 886882003389 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 886882003390 conserved cys residue [active] 886882003391 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 886882003392 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 886882003393 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882003394 non-specific DNA binding site [nucleotide binding]; other site 886882003395 salt bridge; other site 886882003396 sequence-specific DNA binding site [nucleotide binding]; other site 886882003397 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 886882003398 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 886882003399 Acyltransferase family; Region: Acyl_transf_3; pfam01757 886882003400 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 886882003401 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 886882003402 putative ligand binding site [chemical binding]; other site 886882003403 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 886882003404 Cache domain; Region: Cache_1; pfam02743 886882003405 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882003406 dimerization interface [polypeptide binding]; other site 886882003407 Histidine kinase; Region: His_kinase; pfam06580 886882003408 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882003409 ATP binding site [chemical binding]; other site 886882003410 Mg2+ binding site [ion binding]; other site 886882003411 G-X-G motif; other site 886882003412 Response regulator receiver domain; Region: Response_reg; pfam00072 886882003413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882003414 active site 886882003415 phosphorylation site [posttranslational modification] 886882003416 intermolecular recognition site; other site 886882003417 dimerization interface [polypeptide binding]; other site 886882003418 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882003419 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882003420 hydroxylamine reductase; Provisional; Region: PRK12310 886882003421 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 886882003422 ACS interaction site; other site 886882003423 CODH interaction site; other site 886882003424 metal cluster binding site [ion binding]; other site 886882003425 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882003426 non-specific DNA binding site [nucleotide binding]; other site 886882003427 salt bridge; other site 886882003428 sequence-specific DNA binding site [nucleotide binding]; other site 886882003429 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cl00249 886882003430 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from archaea and bacteria; Region: NTP-PPase_COG4997; cd11532 886882003431 metal binding site [ion binding]; metal-binding site 886882003432 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 886882003433 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 886882003434 putative ligand binding site [chemical binding]; other site 886882003435 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 886882003436 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 886882003437 Walker A/P-loop; other site 886882003438 ATP binding site [chemical binding]; other site 886882003439 Q-loop/lid; other site 886882003440 ABC transporter signature motif; other site 886882003441 Walker B; other site 886882003442 D-loop; other site 886882003443 H-loop/switch region; other site 886882003444 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 886882003445 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 886882003446 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 886882003447 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 886882003448 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 886882003449 TM-ABC transporter signature motif; other site 886882003450 short chain dehydrogenase; Provisional; Region: PRK06701 886882003451 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 886882003452 NAD binding site [chemical binding]; other site 886882003453 metal binding site [ion binding]; metal-binding site 886882003454 active site 886882003455 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 886882003456 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 886882003457 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 886882003458 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882003459 putative DNA binding site [nucleotide binding]; other site 886882003460 putative Zn2+ binding site [ion binding]; other site 886882003461 AsnC family; Region: AsnC_trans_reg; pfam01037 886882003462 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 886882003463 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 886882003464 EcsC protein family; Region: EcsC; pfam12787 886882003465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882003466 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882003467 putative substrate translocation pore; other site 886882003468 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 886882003469 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 886882003470 active site 886882003471 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 886882003472 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 886882003473 active site turn [active] 886882003474 phosphorylation site [posttranslational modification] 886882003475 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882003476 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 886882003477 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 886882003478 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 886882003479 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 886882003480 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 886882003481 substrate binding [chemical binding]; other site 886882003482 active site 886882003483 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 886882003484 Cupin domain; Region: Cupin_2; pfam07883 886882003485 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882003486 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882003487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882003488 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 886882003489 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 886882003490 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882003491 FeS/SAM binding site; other site 886882003492 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 886882003493 active site 886882003494 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 886882003495 Ligand Binding Site [chemical binding]; other site 886882003496 Mitochondrial biogenesis AIM24; Region: AIM24; cl00884 886882003497 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 886882003498 Predicted transcriptional regulator [Transcription]; Region: COG2378 886882003499 HTH domain; Region: HTH_11; pfam08279 886882003500 WYL domain; Region: WYL; pfam13280 886882003501 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 886882003502 active site 886882003503 catalytic site [active] 886882003504 substrate binding site [chemical binding]; other site 886882003505 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 886882003506 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 886882003507 putative active site [active] 886882003508 putative metal binding site [ion binding]; other site 886882003509 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 886882003510 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 886882003511 Domain of unknown function (DUF955); Region: DUF955; pfam06114 886882003512 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 886882003513 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882003514 non-specific DNA binding site [nucleotide binding]; other site 886882003515 salt bridge; other site 886882003516 sequence-specific DNA binding site [nucleotide binding]; other site 886882003517 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 886882003518 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 886882003519 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 886882003520 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 886882003521 Phage XkdN-like protein; Region: XkdN; pfam08890 886882003522 Uncharacterized protein containing LysM domain [Function unknown]; Region: XkdP; COG1652 886882003523 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 886882003524 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 886882003525 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 886882003526 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; pfam10076 886882003527 Holin family; Region: Phage_holin_4; pfam05105 886882003528 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 886882003529 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 886882003530 active site 886882003531 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882003532 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 886882003533 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 886882003534 peptide binding site [polypeptide binding]; other site 886882003535 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 886882003536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882003537 dimer interface [polypeptide binding]; other site 886882003538 conserved gate region; other site 886882003539 putative PBP binding loops; other site 886882003540 ABC-ATPase subunit interface; other site 886882003541 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 886882003542 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 886882003543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882003544 dimer interface [polypeptide binding]; other site 886882003545 conserved gate region; other site 886882003546 putative PBP binding loops; other site 886882003547 ABC-ATPase subunit interface; other site 886882003548 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882003549 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882003550 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882003551 Walker A/P-loop; other site 886882003552 ATP binding site [chemical binding]; other site 886882003553 Q-loop/lid; other site 886882003554 ABC transporter signature motif; other site 886882003555 Walker B; other site 886882003556 D-loop; other site 886882003557 H-loop/switch region; other site 886882003558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882003559 Coenzyme A binding pocket [chemical binding]; other site 886882003560 Helix-Turn-Helix DNA binding domain of the BltR transcription regulator; Region: HTH_BltR; cd04782 886882003561 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 886882003562 DNA binding residues [nucleotide binding] 886882003563 dimer interface [polypeptide binding]; other site 886882003564 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 886882003565 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 886882003566 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882003567 Zn2+ binding site [ion binding]; other site 886882003568 Mg2+ binding site [ion binding]; other site 886882003569 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 886882003570 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 886882003571 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 886882003572 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 886882003573 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882003574 S-adenosylmethionine binding site [chemical binding]; other site 886882003575 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 886882003576 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 886882003577 NAD binding site [chemical binding]; other site 886882003578 ligand binding site [chemical binding]; other site 886882003579 catalytic site [active] 886882003580 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 886882003581 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 886882003582 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 886882003583 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 886882003584 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 886882003585 metal-dependent hydrolase; Provisional; Region: PRK00685 886882003586 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 886882003587 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 886882003588 active site 886882003589 dimer interface [polypeptide binding]; other site 886882003590 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 886882003591 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 886882003592 active site 886882003593 FMN binding site [chemical binding]; other site 886882003594 substrate binding site [chemical binding]; other site 886882003595 3Fe-4S cluster binding site [ion binding]; other site 886882003596 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 886882003597 domain interface; other site 886882003598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 886882003599 Histidine kinase; Region: HisKA_3; pfam07730 886882003600 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882003601 ATP binding site [chemical binding]; other site 886882003602 Mg2+ binding site [ion binding]; other site 886882003603 G-X-G motif; other site 886882003604 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 886882003605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882003606 active site 886882003607 phosphorylation site [posttranslational modification] 886882003608 intermolecular recognition site; other site 886882003609 dimerization interface [polypeptide binding]; other site 886882003610 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 886882003611 DNA binding residues [nucleotide binding] 886882003612 dimerization interface [polypeptide binding]; other site 886882003613 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 886882003614 Chain length determinant protein; Region: Wzz; cl15801 886882003615 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 886882003616 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 886882003617 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 886882003618 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 886882003619 active site 886882003620 tetramer interface; other site 886882003621 Bacterial sugar transferase; Region: Bac_transf; pfam02397 886882003622 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 886882003623 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 886882003624 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 886882003625 active site 886882003626 O-Antigen ligase; Region: Wzy_C; pfam04932 886882003627 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 886882003628 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 886882003629 O-Antigen ligase; Region: Wzy_C; pfam04932 886882003630 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 886882003631 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 886882003632 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 886882003633 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 886882003634 putative metal binding site; other site 886882003635 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 886882003636 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 886882003637 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 886882003638 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 886882003639 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 886882003640 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 886882003641 putative ADP-binding pocket [chemical binding]; other site 886882003642 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 886882003643 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 886882003644 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 886882003645 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 886882003646 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 886882003647 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 886882003648 active site 886882003649 Cupin domain; Region: Cupin_2; cl17218 886882003650 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 886882003651 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 886882003652 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 886882003653 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882003654 non-specific DNA binding site [nucleotide binding]; other site 886882003655 salt bridge; other site 886882003656 sequence-specific DNA binding site [nucleotide binding]; other site 886882003657 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 886882003658 Chain length determinant protein; Region: Wzz; cl15801 886882003659 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 886882003660 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 886882003661 Bacterial sugar transferase; Region: Bac_transf; pfam02397 886882003662 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 886882003663 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 886882003664 NADP binding site [chemical binding]; other site 886882003665 active site 886882003666 putative substrate binding site [chemical binding]; other site 886882003667 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 886882003668 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 886882003669 NADP-binding site; other site 886882003670 homotetramer interface [polypeptide binding]; other site 886882003671 substrate binding site [chemical binding]; other site 886882003672 homodimer interface [polypeptide binding]; other site 886882003673 active site 886882003674 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 886882003675 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 886882003676 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 886882003677 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 886882003678 This family is most closely related to the GT1 family of glycosyltransferases. ExpE7 in Sinorhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucans (exopolysaccharide II); Region: GT1_ExpE7_like; cd03823 886882003679 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 886882003680 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 886882003681 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 886882003682 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 886882003683 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 886882003684 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 886882003685 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 886882003686 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 886882003687 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 886882003688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882003689 Walker A/P-loop; other site 886882003690 ATP binding site [chemical binding]; other site 886882003691 Q-loop/lid; other site 886882003692 ABC transporter signature motif; other site 886882003693 Walker B; other site 886882003694 D-loop; other site 886882003695 H-loop/switch region; other site 886882003696 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 886882003697 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 886882003698 Domain of unknown function DUF20; Region: UPF0118; pfam01594 886882003699 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 886882003700 Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664 886882003701 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 886882003702 potential frameshift: common BLAST hit: gi|308067939|ref|YP_003869544.1| Membrane protein 886882003703 Peptidase family M23; Region: Peptidase_M23; pfam01551 886882003704 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 886882003705 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 886882003706 Peptidase family M23; Region: Peptidase_M23; pfam01551 886882003707 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 886882003708 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 886882003709 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 886882003710 putative active site [active] 886882003711 catalytic site [active] 886882003712 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 886882003713 putative active site [active] 886882003714 catalytic site [active] 886882003715 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 886882003716 Uncharacterized conserved protein [Function unknown]; Region: COG1284 886882003717 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 886882003718 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 886882003719 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 886882003720 nucleotide binding site [chemical binding]; other site 886882003721 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 886882003722 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 886882003723 active site 886882003724 dimer interface [polypeptide binding]; other site 886882003725 Glutamine amidotransferase domain; Region: GATase_6; pfam13522 886882003726 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 886882003727 Ligand Binding Site [chemical binding]; other site 886882003728 Molecular Tunnel; other site 886882003729 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 886882003730 active site 886882003731 metal-binding site [ion binding] 886882003732 nucleotide-binding site [chemical binding]; other site 886882003733 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 886882003734 Transglutaminase-like superfamily; Region: Transglut_core3; pfam13471 886882003735 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882003736 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882003737 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882003738 Walker A/P-loop; other site 886882003739 ATP binding site [chemical binding]; other site 886882003740 Q-loop/lid; other site 886882003741 ABC transporter signature motif; other site 886882003742 Walker B; other site 886882003743 D-loop; other site 886882003744 H-loop/switch region; other site 886882003745 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 886882003746 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 886882003747 putative DNA binding site [nucleotide binding]; other site 886882003748 putative homodimer interface [polypeptide binding]; other site 886882003749 Small acid-soluble spore protein H family; Region: SspH; pfam08141 886882003750 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 886882003751 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 886882003752 acetoacetate decarboxylase; Provisional; Region: PRK02265 886882003753 putative acyltransferase; Provisional; Region: PRK05790 886882003754 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 886882003755 dimer interface [polypeptide binding]; other site 886882003756 active site 886882003757 Isochorismatase family; Region: Isochorismatase; pfam00857 886882003758 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 886882003759 catalytic triad [active] 886882003760 conserved cis-peptide bond; other site 886882003761 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 886882003762 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 886882003763 Glycoprotease family; Region: Peptidase_M22; pfam00814 886882003764 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 886882003765 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882003766 Coenzyme A binding pocket [chemical binding]; other site 886882003767 UGMP family protein; Validated; Region: PRK09604 886882003768 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 886882003769 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 886882003770 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 886882003771 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 886882003772 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 886882003773 ABC transporter; Region: ABC_tran_2; pfam12848 886882003774 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 886882003775 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 886882003776 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 886882003777 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 886882003778 trimer interface [polypeptide binding]; other site 886882003779 dimer interface [polypeptide binding]; other site 886882003780 putative active site [active] 886882003781 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 886882003782 MPT binding site; other site 886882003783 trimer interface [polypeptide binding]; other site 886882003784 twin arginine translocase protein A; Provisional; Region: tatA; PRK14861 886882003785 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 886882003786 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 886882003787 oligomerisation interface [polypeptide binding]; other site 886882003788 mobile loop; other site 886882003789 roof hairpin; other site 886882003790 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 886882003791 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 886882003792 ring oligomerisation interface [polypeptide binding]; other site 886882003793 ATP/Mg binding site [chemical binding]; other site 886882003794 stacking interactions; other site 886882003795 hinge regions; other site 886882003796 chaperonin_like superfamily. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The symmetry of type I...; Region: chaperonin_like; cl02777 886882003797 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 886882003798 Phage terminase small subunit; Region: Phage_terminase; pfam10668 886882003799 LysE type translocator; Region: LysE; cl00565 886882003800 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882003801 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882003802 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882003803 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 886882003804 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 886882003805 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 886882003806 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882003807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882003808 dimer interface [polypeptide binding]; other site 886882003809 putative PBP binding loops; other site 886882003810 ABC-ATPase subunit interface; other site 886882003811 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882003812 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882003813 dimer interface [polypeptide binding]; other site 886882003814 conserved gate region; other site 886882003815 putative PBP binding loops; other site 886882003816 ABC-ATPase subunit interface; other site 886882003817 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882003818 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 886882003819 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882003820 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882003821 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 886882003822 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 886882003823 HlyD family secretion protein; Region: HlyD_3; pfam13437 886882003824 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 886882003825 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 886882003826 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 886882003827 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 886882003828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882003829 dimer interface [polypeptide binding]; other site 886882003830 conserved gate region; other site 886882003831 putative PBP binding loops; other site 886882003832 ABC-ATPase subunit interface; other site 886882003833 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 886882003834 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 886882003835 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 886882003836 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 886882003837 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 886882003838 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 886882003839 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 886882003840 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 886882003841 Walker A/P-loop; other site 886882003842 ATP binding site [chemical binding]; other site 886882003843 Q-loop/lid; other site 886882003844 ABC transporter signature motif; other site 886882003845 Walker B; other site 886882003846 D-loop; other site 886882003847 H-loop/switch region; other site 886882003848 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 886882003849 Predicted transcriptional regulators [Transcription]; Region: COG1510 886882003850 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 886882003851 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 886882003852 substrate binding pocket [chemical binding]; other site 886882003853 catalytic triad [active] 886882003854 Cache domain; Region: Cache_1; pfam02743 886882003855 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882003856 dimerization interface [polypeptide binding]; other site 886882003857 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882003858 dimer interface [polypeptide binding]; other site 886882003859 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 886882003860 putative CheW interface [polypeptide binding]; other site 886882003861 EamA-like transporter family; Region: EamA; pfam00892 886882003862 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 886882003863 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 886882003864 Walker A/P-loop; other site 886882003865 ATP binding site [chemical binding]; other site 886882003866 Q-loop/lid; other site 886882003867 ABC transporter signature motif; other site 886882003868 Walker B; other site 886882003869 D-loop; other site 886882003870 H-loop/switch region; other site 886882003871 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882003872 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882003873 dimer interface [polypeptide binding]; other site 886882003874 phosphorylation site [posttranslational modification] 886882003875 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882003876 ATP binding site [chemical binding]; other site 886882003877 Mg2+ binding site [ion binding]; other site 886882003878 G-X-G motif; other site 886882003879 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882003880 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882003881 active site 886882003882 phosphorylation site [posttranslational modification] 886882003883 intermolecular recognition site; other site 886882003884 dimerization interface [polypeptide binding]; other site 886882003885 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882003886 DNA binding site [nucleotide binding] 886882003887 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 886882003888 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 886882003889 Potassium binding sites [ion binding]; other site 886882003890 Cesium cation binding sites [ion binding]; other site 886882003891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882003892 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882003893 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882003894 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 886882003895 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 886882003896 intersubunit interface [polypeptide binding]; other site 886882003897 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 886882003898 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 886882003899 intersubunit interface [polypeptide binding]; other site 886882003900 LysE type translocator; Region: LysE; pfam01810 886882003901 Outer membrane lipoprotein-sorting protein [Cell envelope biogenesis, outer membrane]; Region: LolA; COG2834 886882003902 alanine racemase; Reviewed; Region: alr; PRK00053 886882003903 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 886882003904 active site 886882003905 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 886882003906 dimer interface [polypeptide binding]; other site 886882003907 substrate binding site [chemical binding]; other site 886882003908 catalytic residues [active] 886882003909 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 886882003910 PemK-like protein; Region: PemK; pfam02452 886882003911 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 886882003912 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 886882003913 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 886882003914 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 886882003915 RNA binding site [nucleotide binding]; other site 886882003916 SprT homologues; Region: SprT; cl01182 886882003917 hypothetical protein; Provisional; Region: PRK04351 886882003918 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882003919 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 886882003920 active site 886882003921 motif I; other site 886882003922 motif II; other site 886882003923 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882003924 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 886882003925 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 886882003926 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 886882003927 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882003928 dimerization interface [polypeptide binding]; other site 886882003929 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882003930 putative DNA binding site [nucleotide binding]; other site 886882003931 putative Zn2+ binding site [ion binding]; other site 886882003932 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 886882003933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882003934 non-specific DNA binding site [nucleotide binding]; other site 886882003935 salt bridge; other site 886882003936 sequence-specific DNA binding site [nucleotide binding]; other site 886882003937 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 886882003938 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882003939 non-specific DNA binding site [nucleotide binding]; other site 886882003940 salt bridge; other site 886882003941 sequence-specific DNA binding site [nucleotide binding]; other site 886882003942 UreF; Region: UreF; pfam01730 886882003943 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 886882003944 catalytic residues [active] 886882003945 dimer interface [polypeptide binding]; other site 886882003946 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 886882003947 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 886882003948 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 886882003949 Soluble P-type ATPase [General function prediction only]; Region: COG4087 886882003950 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 886882003951 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882003952 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882003953 putative substrate translocation pore; other site 886882003954 Predicted transcriptional regulators [Transcription]; Region: COG1695 886882003955 Transcriptional regulator PadR-like family; Region: PadR; cl17335 886882003956 manganese transport protein MntH; Reviewed; Region: PRK00701 886882003957 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 886882003958 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 886882003959 Predicted thiol-disulfide oxidoreductase [General function prediction only]; Region: COG3011 886882003960 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 886882003961 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 886882003962 intersubunit interface [polypeptide binding]; other site 886882003963 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 886882003964 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 886882003965 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 886882003966 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882003967 dimer interface [polypeptide binding]; other site 886882003968 ABC-ATPase subunit interface; other site 886882003969 putative PBP binding regions; other site 886882003970 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 886882003971 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882003972 ABC-ATPase subunit interface; other site 886882003973 dimer interface [polypeptide binding]; other site 886882003974 putative PBP binding regions; other site 886882003975 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 886882003976 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 886882003977 Ligand Binding Site [chemical binding]; other site 886882003978 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 886882003979 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 886882003980 Ligand Binding Site [chemical binding]; other site 886882003981 AAA domain; Region: AAA_31; pfam13614 886882003982 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 886882003983 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 886882003984 ATP binding site [chemical binding]; other site 886882003985 Walker A motif; other site 886882003986 hexamer interface [polypeptide binding]; other site 886882003987 Walker B motif; other site 886882003988 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 886882003989 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 886882003990 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 886882003991 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 886882003992 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 886882003993 phosphopeptide binding site; other site 886882003994 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 886882003995 TIGR01777 family protein; Region: yfcH 886882003996 putative NAD(P) binding site [chemical binding]; other site 886882003997 putative active site [active] 886882003998 endonuclease IV; Provisional; Region: PRK01060 886882003999 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 886882004000 AP (apurinic/apyrimidinic) site pocket; other site 886882004001 DNA interaction; other site 886882004002 Metal-binding active site; metal-binding site 886882004003 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 886882004004 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 886882004005 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 886882004006 putative active site [active] 886882004007 putative substrate binding site [chemical binding]; other site 886882004008 putative cosubstrate binding site; other site 886882004009 catalytic site [active] 886882004010 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 886882004011 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 886882004012 TPP-binding site [chemical binding]; other site 886882004013 dimer interface [polypeptide binding]; other site 886882004014 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 886882004015 PYR/PP interface [polypeptide binding]; other site 886882004016 dimer interface [polypeptide binding]; other site 886882004017 TPP binding site [chemical binding]; other site 886882004018 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 886882004019 Protein of unknown function (DUF1255); Region: DUF1255; pfam06865 886882004020 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 886882004021 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 886882004022 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 886882004023 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 886882004024 active site 886882004025 dimer interface [polypeptide binding]; other site 886882004026 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 886882004027 dimer interface [polypeptide binding]; other site 886882004028 active site 886882004029 Uncharacterized conserved protein [Function unknown]; Region: COG1739 886882004030 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 886882004031 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 886882004032 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882004033 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882004034 WHG domain; Region: WHG; pfam13305 886882004035 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 886882004036 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 886882004037 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 886882004038 Walker A/P-loop; other site 886882004039 ATP binding site [chemical binding]; other site 886882004040 Q-loop/lid; other site 886882004041 ABC transporter signature motif; other site 886882004042 Walker B; other site 886882004043 D-loop; other site 886882004044 H-loop/switch region; other site 886882004045 TOBE domain; Region: TOBE_2; pfam08402 886882004046 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 886882004047 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 886882004048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882004049 DNA-binding site [nucleotide binding]; DNA binding site 886882004050 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882004051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882004052 homodimer interface [polypeptide binding]; other site 886882004053 catalytic residue [active] 886882004054 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 886882004055 EamA-like transporter family; Region: EamA; pfam00892 886882004056 EamA-like transporter family; Region: EamA; pfam00892 886882004057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882004058 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 886882004059 active site 886882004060 motif I; other site 886882004061 motif II; other site 886882004062 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882004063 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 886882004064 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 886882004065 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 886882004066 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 886882004067 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882004068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882004069 homodimer interface [polypeptide binding]; other site 886882004070 catalytic residue [active] 886882004071 cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209 886882004072 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 886882004073 catalytic core [active] 886882004074 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 886882004075 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 886882004076 cobalamin binding residues [chemical binding]; other site 886882004077 putative BtuC binding residues; other site 886882004078 dimer interface [polypeptide binding]; other site 886882004079 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 886882004080 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882004081 ABC-ATPase subunit interface; other site 886882004082 dimer interface [polypeptide binding]; other site 886882004083 putative PBP binding regions; other site 886882004084 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 886882004085 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 886882004086 Walker A/P-loop; other site 886882004087 ATP binding site [chemical binding]; other site 886882004088 Q-loop/lid; other site 886882004089 ABC transporter signature motif; other site 886882004090 Walker B; other site 886882004091 D-loop; other site 886882004092 H-loop/switch region; other site 886882004093 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 886882004094 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 886882004095 putative dimer interface [polypeptide binding]; other site 886882004096 active site pocket [active] 886882004097 putative cataytic base [active] 886882004098 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 886882004099 homotrimer interface [polypeptide binding]; other site 886882004100 Walker A motif; other site 886882004101 GTP binding site [chemical binding]; other site 886882004102 Walker B motif; other site 886882004103 cobalamin synthase; Reviewed; Region: cobS; PRK00235 886882004104 cobyric acid synthase; Provisional; Region: PRK00784 886882004105 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 886882004106 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 886882004107 catalytic triad [active] 886882004108 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882004109 dimerization interface [polypeptide binding]; other site 886882004110 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882004111 dimer interface [polypeptide binding]; other site 886882004112 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 886882004113 putative CheW interface [polypeptide binding]; other site 886882004114 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882004115 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 886882004116 transcriptional antiterminator BglG; Provisional; Region: PRK09772 886882004117 CAT RNA binding domain; Region: CAT_RBD; smart01061 886882004118 PRD domain; Region: PRD; pfam00874 886882004119 PRD domain; Region: PRD; pfam00874 886882004120 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 886882004121 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 886882004122 active site turn [active] 886882004123 phosphorylation site [posttranslational modification] 886882004124 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882004125 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 886882004126 HPr interaction site; other site 886882004127 glycerol kinase (GK) interaction site [polypeptide binding]; other site 886882004128 active site 886882004129 phosphorylation site [posttranslational modification] 886882004130 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 886882004131 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 886882004132 Uncharacterized member of the PurR regulon [General function prediction only]; Region: yhhQ; COG1738 886882004133 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 886882004134 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 886882004135 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 886882004136 active site 886882004137 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 886882004138 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 886882004139 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882004140 Coenzyme A binding pocket [chemical binding]; other site 886882004141 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 886882004142 Uncharacterized conserved protein [Function unknown]; Region: COG2966 886882004143 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 886882004144 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 886882004145 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882004146 motif II; other site 886882004147 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 886882004148 active site 886882004149 ATP binding site [chemical binding]; other site 886882004150 substrate binding site [chemical binding]; other site 886882004151 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 886882004152 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 886882004153 Malic enzyme, N-terminal domain; Region: malic; pfam00390 886882004154 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 886882004155 putative NAD(P) binding site [chemical binding]; other site 886882004156 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 886882004157 Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553 886882004158 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 886882004159 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 886882004160 active site 886882004161 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 886882004162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 886882004163 ATP binding site [chemical binding]; other site 886882004164 putative Mg++ binding site [ion binding]; other site 886882004165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882004166 nucleotide binding region [chemical binding]; other site 886882004167 ATP-binding site [chemical binding]; other site 886882004168 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 886882004169 HRDC domain; Region: HRDC; pfam00570 886882004170 B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068 886882004171 Radical SAM superfamily; Region: Radical_SAM; pfam04055 886882004172 Protein of unknown function (DUF4080); Region: DUF4080; pfam13311 886882004173 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 886882004174 dimer interface [polypeptide binding]; other site 886882004175 Alkaline phosphatase homologues; Region: alkPPc; smart00098 886882004176 active site 886882004177 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 886882004178 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 886882004179 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882004180 S-adenosylmethionine binding site [chemical binding]; other site 886882004181 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882004182 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 886882004183 Coenzyme A binding pocket [chemical binding]; other site 886882004184 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 886882004185 putative active site [active] 886882004186 nucleotide binding site [chemical binding]; other site 886882004187 nudix motif; other site 886882004188 putative metal binding site [ion binding]; other site 886882004189 Predicted acetyltransferase [General function prediction only]; Region: COG3981 886882004190 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 886882004191 Coenzyme A binding pocket [chemical binding]; other site 886882004192 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 886882004193 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 886882004194 HEAT repeats; Region: HEAT_2; pfam13646 886882004195 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 886882004196 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882004197 Zn2+ binding site [ion binding]; other site 886882004198 Mg2+ binding site [ion binding]; other site 886882004199 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 886882004200 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 886882004201 intersubunit interface [polypeptide binding]; other site 886882004202 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 886882004203 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882004204 ABC-ATPase subunit interface; other site 886882004205 dimer interface [polypeptide binding]; other site 886882004206 putative PBP binding regions; other site 886882004207 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 886882004208 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882004209 ABC-ATPase subunit interface; other site 886882004210 dimer interface [polypeptide binding]; other site 886882004211 putative PBP binding regions; other site 886882004212 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 886882004213 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 886882004214 SPFH domain / Band 7 family; Region: Band_7; pfam01145 886882004215 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 886882004216 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 886882004217 GAF domain; Region: GAF; cl17456 886882004218 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 886882004219 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 886882004220 DNA binding residues [nucleotide binding] 886882004221 dimerization interface [polypeptide binding]; other site 886882004222 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 886882004223 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882004224 S-adenosylmethionine binding site [chemical binding]; other site 886882004225 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 886882004226 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 886882004227 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 886882004228 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882004229 motif II; other site 886882004230 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 886882004231 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 886882004232 Protein of unknown function (DUF2809); Region: DUF2809; pfam10990 886882004233 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 886882004234 active site 886882004235 catalytic triad [active] 886882004236 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882004237 S-adenosylmethionine binding site [chemical binding]; other site 886882004238 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 886882004239 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 886882004240 GIY-YIG domain of LuxR and ArsR family transcriptional regulators, and uncharacterized hypothetical proteins found in bacteria; Region: GIY-YIG_LuxR_like; cd10451 886882004241 GIY-YIG motif/motif A; other site 886882004242 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 886882004243 HEAT repeats; Region: HEAT_2; pfam13646 886882004244 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it, thus inhibiting its potentially lethal RNase activity inside the...; Region: Barstar_like; cl01048 886882004245 RNAase interaction site [polypeptide binding]; other site 886882004246 H+ Antiporter protein; Region: 2A0121; TIGR00900 886882004247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882004248 putative substrate translocation pore; other site 886882004249 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 886882004250 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 886882004251 TPP-binding site [chemical binding]; other site 886882004252 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 886882004253 dimer interface [polypeptide binding]; other site 886882004254 PYR/PP interface [polypeptide binding]; other site 886882004255 TPP binding site [chemical binding]; other site 886882004256 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 886882004257 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 886882004258 E3 interaction surface; other site 886882004259 lipoyl attachment site [posttranslational modification]; other site 886882004260 e3 binding domain; Region: E3_binding; pfam02817 886882004261 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 886882004262 metal-dependent hydrolase; Provisional; Region: PRK13291 886882004263 DinB superfamily; Region: DinB_2; pfam12867 886882004264 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 886882004265 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 886882004266 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 886882004267 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 886882004268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882004269 S-adenosylmethionine binding site [chemical binding]; other site 886882004270 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 886882004271 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882004272 S-adenosylmethionine binding site [chemical binding]; other site 886882004273 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 886882004274 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 886882004275 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 886882004276 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 886882004277 active site 886882004278 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 886882004279 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 886882004280 DXD motif; other site 886882004281 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 886882004282 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 886882004283 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 886882004284 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 886882004285 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 886882004286 23S rRNA binding site [nucleotide binding]; other site 886882004287 L21 binding site [polypeptide binding]; other site 886882004288 L13 binding site [polypeptide binding]; other site 886882004289 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 886882004290 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 886882004291 ligand binding site [chemical binding]; other site 886882004292 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 886882004293 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882004294 Walker A/P-loop; other site 886882004295 ATP binding site [chemical binding]; other site 886882004296 Q-loop/lid; other site 886882004297 ABC transporter signature motif; other site 886882004298 Walker B; other site 886882004299 D-loop; other site 886882004300 H-loop/switch region; other site 886882004301 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 886882004302 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 886882004303 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 886882004304 TM-ABC transporter signature motif; other site 886882004305 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 886882004306 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 886882004307 TM-ABC transporter signature motif; other site 886882004308 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 886882004309 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882004310 Coenzyme A binding pocket [chemical binding]; other site 886882004311 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 886882004312 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 886882004313 PYR/PP interface [polypeptide binding]; other site 886882004314 dimer interface [polypeptide binding]; other site 886882004315 TPP binding site [chemical binding]; other site 886882004316 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 886882004317 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 886882004318 TPP-binding site [chemical binding]; other site 886882004319 dimer interface [polypeptide binding]; other site 886882004320 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 886882004321 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 886882004322 putative valine binding site [chemical binding]; other site 886882004323 dimer interface [polypeptide binding]; other site 886882004324 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 886882004325 ketol-acid reductoisomerase; Provisional; Region: PRK05479 886882004326 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 886882004327 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 886882004328 2-isopropylmalate synthase; Validated; Region: PRK00915 886882004329 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 886882004330 active site 886882004331 catalytic residues [active] 886882004332 metal binding site [ion binding]; metal-binding site 886882004333 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 886882004334 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 886882004335 tartrate dehydrogenase; Region: TTC; TIGR02089 886882004336 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 886882004337 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 886882004338 dimer interface [polypeptide binding]; other site 886882004339 decamer (pentamer of dimers) interface [polypeptide binding]; other site 886882004340 catalytic triad [active] 886882004341 peroxidatic and resolving cysteines [active] 886882004342 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 886882004343 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882004344 putative active site [active] 886882004345 heme pocket [chemical binding]; other site 886882004346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882004347 dimer interface [polypeptide binding]; other site 886882004348 phosphorylation site [posttranslational modification] 886882004349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882004350 ATP binding site [chemical binding]; other site 886882004351 Mg2+ binding site [ion binding]; other site 886882004352 G-X-G motif; other site 886882004353 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 886882004354 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 886882004355 metal binding site [ion binding]; metal-binding site 886882004356 active site 886882004357 I-site; other site 886882004358 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 886882004359 Pectate lyase; Region: Pec_lyase_C; cl01593 886882004360 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 886882004361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882004362 Walker A/P-loop; other site 886882004363 ATP binding site [chemical binding]; other site 886882004364 Q-loop/lid; other site 886882004365 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 886882004366 ABC transporter signature motif; other site 886882004367 Walker B; other site 886882004368 D-loop; other site 886882004369 ABC transporter; Region: ABC_tran_2; pfam12848 886882004370 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 886882004371 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 886882004372 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 886882004373 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 886882004374 dimer interface [polypeptide binding]; other site 886882004375 motif 1; other site 886882004376 active site 886882004377 motif 2; other site 886882004378 motif 3; other site 886882004379 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 886882004380 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 886882004381 putative tRNA-binding site [nucleotide binding]; other site 886882004382 B3/4 domain; Region: B3_4; pfam03483 886882004383 tRNA synthetase B5 domain; Region: B5; smart00874 886882004384 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 886882004385 dimer interface [polypeptide binding]; other site 886882004386 motif 1; other site 886882004387 motif 3; other site 886882004388 motif 2; other site 886882004389 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 886882004390 Cell division protein ZapA; Region: ZapA; cl01146 886882004391 Membrane protein of unknown function; Region: DUF360; pfam04020 886882004392 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 886882004393 MutS domain III; Region: MutS_III; pfam05192 886882004394 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 886882004395 Walker A/P-loop; other site 886882004396 ATP binding site [chemical binding]; other site 886882004397 Q-loop/lid; other site 886882004398 ABC transporter signature motif; other site 886882004399 Walker B; other site 886882004400 D-loop; other site 886882004401 H-loop/switch region; other site 886882004402 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 886882004403 Predicted membrane protein [Function unknown]; Region: COG3766 886882004404 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 886882004405 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 886882004406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882004407 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882004408 putative substrate translocation pore; other site 886882004409 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 886882004410 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 886882004411 Coat F domain; Region: Coat_F; pfam07875 886882004412 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 886882004413 AsnC family; Region: AsnC_trans_reg; pfam01037 886882004414 hypothetical protein; Validated; Region: PRK07682 886882004415 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882004416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882004417 homodimer interface [polypeptide binding]; other site 886882004418 catalytic residue [active] 886882004419 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 886882004420 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 886882004421 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 886882004422 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 886882004423 RNA binding surface [nucleotide binding]; other site 886882004424 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 886882004425 active site 886882004426 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 886882004427 ArsC family; Region: ArsC; pfam03960 886882004428 putative ArsC-like catalytic residues; other site 886882004429 putative TRX-like catalytic residues [active] 886882004430 5'-3' exonuclease; Region: 53EXOc; smart00475 886882004431 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 886882004432 active site 886882004433 metal binding site 1 [ion binding]; metal-binding site 886882004434 putative 5' ssDNA interaction site; other site 886882004435 metal binding site 3; metal-binding site 886882004436 metal binding site 2 [ion binding]; metal-binding site 886882004437 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 886882004438 putative DNA binding site [nucleotide binding]; other site 886882004439 putative metal binding site [ion binding]; other site 886882004440 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 886882004441 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 886882004442 nucleotide binding site [chemical binding]; other site 886882004443 HRDC domain; Region: HRDC; pfam00570 886882004444 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 886882004445 Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822 886882004446 oligomer interface [polypeptide binding]; other site 886882004447 metal binding site [ion binding]; metal-binding site 886882004448 metal binding site [ion binding]; metal-binding site 886882004449 putative Cl binding site [ion binding]; other site 886882004450 aspartate ring; other site 886882004451 basic sphincter; other site 886882004452 hydrophobic gate; other site 886882004453 periplasmic entrance; other site 886882004454 Homoserine O-succinyltransferase; Region: HTS; pfam04204 886882004455 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 886882004456 proposed active site lysine [active] 886882004457 conserved cys residue [active] 886882004458 cystathionine gamma-synthase; Reviewed; Region: PRK08247 886882004459 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 886882004460 homodimer interface [polypeptide binding]; other site 886882004461 substrate-cofactor binding pocket; other site 886882004462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882004463 catalytic residue [active] 886882004464 cystathionine beta-lyase; Provisional; Region: PRK08064 886882004465 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 886882004466 homodimer interface [polypeptide binding]; other site 886882004467 substrate-cofactor binding pocket; other site 886882004468 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882004469 catalytic residue [active] 886882004470 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 886882004471 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882004472 FeS/SAM binding site; other site 886882004473 Uncharacterized conserved protein [Function unknown]; Region: COG1284 886882004474 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 886882004475 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 886882004476 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 886882004477 Putative regulatory, ligand-binding protein related to C-terminal domains of K+ channels [Inorganic ion transport and metabolism]; Region: COG0490 886882004478 TrkA-C domain; Region: TrkA_C; pfam02080 886882004479 YtxC-like family; Region: YtxC; pfam08812 886882004480 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584 886882004481 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 886882004482 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 886882004483 protein binding site [polypeptide binding]; other site 886882004484 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882004485 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882004486 active site 886882004487 phosphorylation site [posttranslational modification] 886882004488 intermolecular recognition site; other site 886882004489 dimerization interface [polypeptide binding]; other site 886882004490 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882004491 DNA binding site [nucleotide binding] 886882004492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882004493 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882004494 dimerization interface [polypeptide binding]; other site 886882004495 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882004496 dimer interface [polypeptide binding]; other site 886882004497 phosphorylation site [posttranslational modification] 886882004498 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882004499 ATP binding site [chemical binding]; other site 886882004500 Mg2+ binding site [ion binding]; other site 886882004501 G-X-G motif; other site 886882004502 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 886882004503 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 886882004504 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 886882004505 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 886882004506 glutamine synthetase, type I; Region: GlnA; TIGR00653 886882004507 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 886882004508 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 886882004509 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 886882004510 homodimer interface [polypeptide binding]; other site 886882004511 substrate-cofactor binding pocket; other site 886882004512 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882004513 catalytic residue [active] 886882004514 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 886882004515 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 886882004516 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 886882004517 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 886882004518 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882004519 active site 886882004520 phosphorylation site [posttranslational modification] 886882004521 intermolecular recognition site; other site 886882004522 dimerization interface [polypeptide binding]; other site 886882004523 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 886882004524 DNA binding residues [nucleotide binding] 886882004525 dimerization interface [polypeptide binding]; other site 886882004526 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882004527 Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155 886882004528 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882004529 homodimer interface [polypeptide binding]; other site 886882004530 catalytic residue [active] 886882004531 Uncharacterized conserved protein (DUF2161); Region: DUF2161; cl02298 886882004532 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 886882004533 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 886882004534 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 886882004535 heme-binding site [chemical binding]; other site 886882004536 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882004537 dimer interface [polypeptide binding]; other site 886882004538 putative CheW interface [polypeptide binding]; other site 886882004539 N-acetyltransferase; Region: Acetyltransf_2; cl00949 886882004540 spore coat protein YsxE; Region: spore_ysxE; TIGR02904 886882004541 Phosphotransferase enzyme family; Region: APH; pfam01636 886882004542 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 886882004543 active site 886882004544 ATP binding site [chemical binding]; other site 886882004545 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 886882004546 Predicted membrane protein [Function unknown]; Region: COG3212 886882004547 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 886882004548 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 886882004549 Predicted membrane protein [Function unknown]; Region: COG3212 886882004550 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 886882004551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882004552 HAMP domain; Region: HAMP; pfam00672 886882004553 dimerization interface [polypeptide binding]; other site 886882004554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882004555 dimer interface [polypeptide binding]; other site 886882004556 phosphorylation site [posttranslational modification] 886882004557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882004558 Mg2+ binding site [ion binding]; other site 886882004559 G-X-G motif; other site 886882004560 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882004561 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882004562 active site 886882004563 phosphorylation site [posttranslational modification] 886882004564 intermolecular recognition site; other site 886882004565 dimerization interface [polypeptide binding]; other site 886882004566 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882004567 DNA binding site [nucleotide binding] 886882004568 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882004569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882004570 active site 886882004571 phosphorylation site [posttranslational modification] 886882004572 intermolecular recognition site; other site 886882004573 dimerization interface [polypeptide binding]; other site 886882004574 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882004575 DNA binding site [nucleotide binding] 886882004576 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882004577 HAMP domain; Region: HAMP; pfam00672 886882004578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882004579 dimer interface [polypeptide binding]; other site 886882004580 phosphorylation site [posttranslational modification] 886882004581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882004582 ATP binding site [chemical binding]; other site 886882004583 Mg2+ binding site [ion binding]; other site 886882004584 G-X-G motif; other site 886882004585 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 886882004586 SpoVR like protein; Region: SpoVR; pfam04293 886882004587 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 886882004588 sporulation protein YhbH; Region: spore_yhbH; TIGR02877 886882004589 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882004590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882004591 active site 886882004592 phosphorylation site [posttranslational modification] 886882004593 intermolecular recognition site; other site 886882004594 dimerization interface [polypeptide binding]; other site 886882004595 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882004596 DNA binding site [nucleotide binding] 886882004597 Protein of unknown function (DUF805); Region: DUF805; cl01224 886882004598 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882004599 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882004600 dimer interface [polypeptide binding]; other site 886882004601 phosphorylation site [posttranslational modification] 886882004602 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882004603 ATP binding site [chemical binding]; other site 886882004604 Mg2+ binding site [ion binding]; other site 886882004605 G-X-G motif; other site 886882004606 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 886882004607 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 886882004608 Walker A/P-loop; other site 886882004609 ATP binding site [chemical binding]; other site 886882004610 Q-loop/lid; other site 886882004611 ABC transporter signature motif; other site 886882004612 Walker B; other site 886882004613 D-loop; other site 886882004614 H-loop/switch region; other site 886882004615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 886882004616 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 886882004617 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 886882004618 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 886882004619 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 886882004620 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 886882004621 active site 886882004622 zinc binding site [ion binding]; other site 886882004623 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 886882004624 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 886882004625 active site 886882004626 zinc binding site [ion binding]; other site 886882004627 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882004628 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882004629 DNA binding site [nucleotide binding] 886882004630 Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737 886882004631 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 886882004632 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 886882004633 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882004634 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882004635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882004636 Walker A/P-loop; other site 886882004637 ATP binding site [chemical binding]; other site 886882004638 Q-loop/lid; other site 886882004639 ABC transporter signature motif; other site 886882004640 Walker B; other site 886882004641 D-loop; other site 886882004642 H-loop/switch region; other site 886882004643 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 886882004644 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 886882004645 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882004646 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882004647 putative substrate translocation pore; other site 886882004648 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 886882004649 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882004650 non-specific DNA binding site [nucleotide binding]; other site 886882004651 salt bridge; other site 886882004652 sequence-specific DNA binding site [nucleotide binding]; other site 886882004653 Cupin domain; Region: Cupin_2; pfam07883 886882004654 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 886882004655 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 886882004656 active site 886882004657 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 886882004658 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 886882004659 putative sugar binding sites [chemical binding]; other site 886882004660 Q-X-W motif; other site 886882004661 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 886882004662 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 886882004663 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 886882004664 active site 886882004665 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 886882004666 S-layer homology domain; Region: SLH; pfam00395 886882004667 S-layer homology domain; Region: SLH; pfam00395 886882004668 S-layer homology domain; Region: SLH; pfam00395 886882004669 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 886882004670 active site 886882004671 EDD domain protein, DegV family; Region: DegV; TIGR00762 886882004672 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 886882004673 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 886882004674 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 886882004675 active site 886882004676 NTP binding site [chemical binding]; other site 886882004677 metal binding triad [ion binding]; metal-binding site 886882004678 KNTase C-terminal domain; Region: KNTase_C; pfam07827 886882004679 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 886882004680 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882004681 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882004682 DNA binding residues [nucleotide binding] 886882004683 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 886882004684 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 886882004685 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 886882004686 ABC-type Fe3+-citrate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FecB; COG4594 886882004687 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 886882004688 siderophore binding site; other site 886882004689 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 886882004690 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882004691 ABC-ATPase subunit interface; other site 886882004692 dimer interface [polypeptide binding]; other site 886882004693 putative PBP binding regions; other site 886882004694 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882004695 ABC-ATPase subunit interface; other site 886882004696 dimer interface [polypeptide binding]; other site 886882004697 putative PBP binding regions; other site 886882004698 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882004699 putative DNA binding site [nucleotide binding]; other site 886882004700 putative Zn2+ binding site [ion binding]; other site 886882004701 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 886882004702 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882004703 putative substrate translocation pore; other site 886882004704 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 886882004705 active site 886882004706 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882004707 Coenzyme A binding pocket [chemical binding]; other site 886882004708 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 886882004709 non-specific DNA binding site [nucleotide binding]; other site 886882004710 salt bridge; other site 886882004711 sequence-specific DNA binding site [nucleotide binding]; other site 886882004712 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882004713 preprotein translocase subunit SecA; Reviewed; Region: PRK12326 886882004714 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 886882004715 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882004716 nucleotide binding region [chemical binding]; other site 886882004717 ATP-binding site [chemical binding]; other site 886882004718 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882004719 Domain of unknown function (DUF1871); Region: DUF1871; pfam08958 886882004720 Restriction endonuclease; Region: Mrr_cat; pfam04471 886882004721 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 886882004722 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 886882004723 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 886882004724 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 886882004725 Putative amidase domain; Region: Amidase_6; pfam12671 886882004726 hypothetical protein; Provisional; Region: PRK06851 886882004727 bifunctional pantoate ligase/cytidylate kinase; Provisional; Region: PRK13477 886882004728 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 886882004729 Protein with unknown function (DUF469); Region: DUF469; cl01237 886882004730 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 886882004731 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 886882004732 catalytic residues [active] 886882004733 catalytic nucleophile [active] 886882004734 Presynaptic Site I dimer interface [polypeptide binding]; other site 886882004735 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 886882004736 Synaptic Flat tetramer interface [polypeptide binding]; other site 886882004737 Synaptic Site I dimer interface [polypeptide binding]; other site 886882004738 DNA binding site [nucleotide binding] 886882004739 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882004740 non-specific DNA binding site [nucleotide binding]; other site 886882004741 salt bridge; other site 886882004742 sequence-specific DNA binding site [nucleotide binding]; other site 886882004743 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 886882004744 Pyocin large subunit [General function prediction only]; Region: COG5529 886882004745 Cysteine-rich CPCC; Region: Cys_rich_CPCC; pfam14206 886882004746 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 886882004747 active site 886882004748 catalytic site [active] 886882004749 substrate binding site [chemical binding]; other site 886882004750 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 886882004751 amidase; Provisional; Region: PRK06828 886882004752 Amidase; Region: Amidase; cl11426 886882004753 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882004754 Protein with unknown function (DUF469); Region: DUF469; cl01237 886882004755 UPF0489 domain; Region: UPF0489; pfam12640 886882004756 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 886882004757 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 886882004758 catalytic residues [active] 886882004759 catalytic nucleophile [active] 886882004760 Presynaptic Site I dimer interface [polypeptide binding]; other site 886882004761 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 886882004762 Synaptic Flat tetramer interface [polypeptide binding]; other site 886882004763 Synaptic Site I dimer interface [polypeptide binding]; other site 886882004764 DNA binding site [nucleotide binding] 886882004765 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882004766 non-specific DNA binding site [nucleotide binding]; other site 886882004767 salt bridge; other site 886882004768 sequence-specific DNA binding site [nucleotide binding]; other site 886882004769 Flagellar biosynthesis protein, FliO; Region: FliO; pfam04347 886882004770 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 886882004771 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 886882004772 Domain of unknown function (DUF1805); Region: DUF1805; cl01339 886882004773 Transposase; Region: HTH_Tnp_1; cl17663 886882004774 putative transposase OrfB; Reviewed; Region: PHA02517 886882004775 HTH-like domain; Region: HTH_21; pfam13276 886882004776 Integrase core domain; Region: rve; pfam00665 886882004777 Integrase core domain; Region: rve_3; pfam13683 886882004778 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 886882004779 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 886882004780 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 886882004781 Phosphotransferase enzyme family; Region: APH; pfam01636 886882004782 Ferritin-like domain; Region: Ferritin; pfam00210 886882004783 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 886882004784 dimerization interface [polypeptide binding]; other site 886882004785 DPS ferroxidase diiron center [ion binding]; other site 886882004786 ion pore; other site 886882004787 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 886882004788 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 886882004789 Walker A/P-loop; other site 886882004790 ATP binding site [chemical binding]; other site 886882004791 Q-loop/lid; other site 886882004792 ABC transporter signature motif; other site 886882004793 Walker B; other site 886882004794 D-loop; other site 886882004795 H-loop/switch region; other site 886882004796 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 886882004797 FeS assembly protein SufD; Region: sufD; TIGR01981 886882004798 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 886882004799 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 886882004800 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 886882004801 catalytic residue [active] 886882004802 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 886882004803 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 886882004804 trimerization site [polypeptide binding]; other site 886882004805 active site 886882004806 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 886882004807 FeS assembly protein SufB; Region: sufB; TIGR01980 886882004808 Transposase; Region: HTH_Tnp_1; cl17663 886882004809 putative transposase OrfB; Reviewed; Region: PHA02517 886882004810 HTH-like domain; Region: HTH_21; pfam13276 886882004811 Integrase core domain; Region: rve; pfam00665 886882004812 Integrase core domain; Region: rve_3; pfam13683 886882004813 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 886882004814 CAAX protease self-immunity; Region: Abi; pfam02517 886882004815 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882004816 non-specific DNA binding site [nucleotide binding]; other site 886882004817 salt bridge; other site 886882004818 sequence-specific DNA binding site [nucleotide binding]; other site 886882004819 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 886882004820 dimanganese center [ion binding]; other site 886882004821 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 886882004822 dimanganese center [ion binding]; other site 886882004823 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 886882004824 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882004825 Zn2+ binding site [ion binding]; other site 886882004826 Mg2+ binding site [ion binding]; other site 886882004827 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 886882004828 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 886882004829 active site 886882004830 metal binding site [ion binding]; metal-binding site 886882004831 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 886882004832 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 886882004833 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882004834 Zn2+ binding site [ion binding]; other site 886882004835 Mg2+ binding site [ion binding]; other site 886882004836 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 886882004837 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882004838 FeS/SAM binding site; other site 886882004839 YfkB-like domain; Region: YfkB; pfam08756 886882004840 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 886882004841 Domain of unknown function DUF21; Region: DUF21; pfam01595 886882004842 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 886882004843 Transporter associated domain; Region: CorC_HlyC; smart01091 886882004844 Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007 886882004845 CotJB protein; Region: CotJB; pfam12652 886882004846 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 886882004847 dimanganese center [ion binding]; other site 886882004848 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 886882004849 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882004850 DNA-binding site [nucleotide binding]; DNA binding site 886882004851 UTRA domain; Region: UTRA; pfam07702 886882004852 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 886882004853 A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS_1; cd05710 886882004854 putative active site [active] 886882004855 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 886882004856 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 886882004857 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 886882004858 substrate binding site [chemical binding]; other site 886882004859 ATP binding site [chemical binding]; other site 886882004860 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 886882004861 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 886882004862 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 886882004863 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 886882004864 Metal-binding active site; metal-binding site 886882004865 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 886882004866 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 886882004867 putative metal binding site; other site 886882004868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 886882004869 binding surface 886882004870 TPR motif; other site 886882004871 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 886882004872 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 886882004873 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 886882004874 active site 886882004875 Methyltransferase domain; Region: Methyltransf_23; pfam13489 886882004876 Methyltransferase domain; Region: Methyltransf_11; pfam08241 886882004877 Methyltransferase domain; Region: Methyltransf_31; pfam13847 886882004878 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882004879 S-adenosylmethionine binding site [chemical binding]; other site 886882004880 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 886882004881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882004882 motif II; other site 886882004883 alpha-L-glutamate ligases, RimK family; Region: rimK_fam; TIGR00768 886882004884 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 886882004885 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 886882004886 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 886882004887 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 886882004888 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 886882004889 hypothetical protein; Provisional; Region: PRK13676 886882004890 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 886882004891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882004892 DNA-binding site [nucleotide binding]; DNA binding site 886882004893 DRTGG domain; Region: DRTGG; pfam07085 886882004894 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 886882004895 Thioesterase superfamily; Region: 4HBT; pfam03061 886882004896 Sporulation protein YtrH; Region: Spore_YtrH; pfam14034 886882004897 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826 886882004898 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 886882004899 active site 886882004900 PHP Thumb interface [polypeptide binding]; other site 886882004901 metal binding site [ion binding]; metal-binding site 886882004902 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 886882004903 generic binding surface II; other site 886882004904 generic binding surface I; other site 886882004905 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 886882004906 tetramer interfaces [polypeptide binding]; other site 886882004907 binuclear metal-binding site [ion binding]; other site 886882004908 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 886882004909 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 886882004910 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 886882004911 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 886882004912 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 886882004913 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 886882004914 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 886882004915 domain interfaces; other site 886882004916 active site 886882004917 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882004918 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882004919 LysR substrate binding domain; Region: LysR_substrate; pfam03466 886882004920 dimerization interface [polypeptide binding]; other site 886882004921 PBP superfamily domain; Region: PBP_like_2; cl17296 886882004922 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 886882004923 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 886882004924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882004925 dimer interface [polypeptide binding]; other site 886882004926 conserved gate region; other site 886882004927 putative PBP binding loops; other site 886882004928 ABC-ATPase subunit interface; other site 886882004929 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 886882004930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882004931 dimer interface [polypeptide binding]; other site 886882004932 conserved gate region; other site 886882004933 putative PBP binding loops; other site 886882004934 ABC-ATPase subunit interface; other site 886882004935 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 886882004936 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 886882004937 Walker A/P-loop; other site 886882004938 ATP binding site [chemical binding]; other site 886882004939 Q-loop/lid; other site 886882004940 ABC transporter signature motif; other site 886882004941 Walker B; other site 886882004942 D-loop; other site 886882004943 H-loop/switch region; other site 886882004944 Pectic acid lyase; Region: Pec_lyase; pfam09492 886882004945 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 886882004946 active site 886882004947 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 886882004948 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 886882004949 Domain of unknown function DUF20; Region: UPF0118; pfam01594 886882004950 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 886882004951 Citrate synthase; Region: Citrate_synt; pfam00285 886882004952 oxalacetate binding site [chemical binding]; other site 886882004953 citrylCoA binding site [chemical binding]; other site 886882004954 coenzyme A binding site [chemical binding]; other site 886882004955 catalytic triad [active] 886882004956 isocitrate dehydrogenase; Validated; Region: PRK06451 886882004957 isocitrate dehydrogenase; Reviewed; Region: PRK07006 886882004958 malate dehydrogenase; Reviewed; Region: PRK06223 886882004959 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 886882004960 NAD(P) binding site [chemical binding]; other site 886882004961 dimer interface [polypeptide binding]; other site 886882004962 tetramer (dimer of dimers) interface [polypeptide binding]; other site 886882004963 substrate binding site [chemical binding]; other site 886882004964 short chain dehydrogenase; Provisional; Region: PRK06701 886882004965 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 886882004966 NAD binding site [chemical binding]; other site 886882004967 metal binding site [ion binding]; metal-binding site 886882004968 active site 886882004969 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 886882004970 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882004971 dimerization interface [polypeptide binding]; other site 886882004972 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 886882004973 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 886882004974 putative active site [active] 886882004975 heme pocket [chemical binding]; other site 886882004976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882004977 dimer interface [polypeptide binding]; other site 886882004978 phosphorylation site [posttranslational modification] 886882004979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882004980 ATP binding site [chemical binding]; other site 886882004981 Mg2+ binding site [ion binding]; other site 886882004982 G-X-G motif; other site 886882004983 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882004984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882004985 active site 886882004986 phosphorylation site [posttranslational modification] 886882004987 intermolecular recognition site; other site 886882004988 dimerization interface [polypeptide binding]; other site 886882004989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882004990 DNA binding site [nucleotide binding] 886882004991 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 886882004992 FOG: CBS domain [General function prediction only]; Region: COG0517 886882004993 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882004994 dimer interface [polypeptide binding]; other site 886882004995 putative CheW interface [polypeptide binding]; other site 886882004996 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 886882004997 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 886882004998 Walker A/P-loop; other site 886882004999 ATP binding site [chemical binding]; other site 886882005000 Q-loop/lid; other site 886882005001 ABC transporter signature motif; other site 886882005002 Walker B; other site 886882005003 D-loop; other site 886882005004 H-loop/switch region; other site 886882005005 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 886882005006 PhoU domain; Region: PhoU; pfam01895 886882005007 PhoU domain; Region: PhoU; pfam01895 886882005008 DNA polymerase I; Provisional; Region: PRK05755 886882005009 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 886882005010 active site 886882005011 metal binding site 1 [ion binding]; metal-binding site 886882005012 putative 5' ssDNA interaction site; other site 886882005013 metal binding site 3; metal-binding site 886882005014 metal binding site 2 [ion binding]; metal-binding site 886882005015 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 886882005016 putative DNA binding site [nucleotide binding]; other site 886882005017 putative metal binding site [ion binding]; other site 886882005018 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 886882005019 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 886882005020 active site 886882005021 DNA binding site [nucleotide binding] 886882005022 catalytic site [active] 886882005023 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 886882005024 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 886882005025 DNA binding site [nucleotide binding] 886882005026 catalytic residue [active] 886882005027 H2TH interface [polypeptide binding]; other site 886882005028 putative catalytic residues [active] 886882005029 turnover-facilitating residue; other site 886882005030 intercalation triad [nucleotide binding]; other site 886882005031 8OG recognition residue [nucleotide binding]; other site 886882005032 putative reading head residues; other site 886882005033 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 886882005034 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 886882005035 putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840 886882005036 Domain of unknown function DUF; Region: DUF204; pfam02659 886882005037 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 886882005038 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 886882005039 CoA-binding site [chemical binding]; other site 886882005040 ATP-binding [chemical binding]; other site 886882005041 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 886882005042 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 886882005043 N-acetyl-D-glucosamine binding site [chemical binding]; other site 886882005044 catalytic residue [active] 886882005045 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 886882005046 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 886882005047 ATP cone domain; Region: ATP-cone; pfam03477 886882005048 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 886882005049 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 886882005050 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882005051 Coenzyme A binding pocket [chemical binding]; other site 886882005052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 886882005053 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 886882005054 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 886882005055 DNA binding residues [nucleotide binding] 886882005056 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 886882005057 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882005058 FeS/SAM binding site; other site 886882005059 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 886882005060 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 886882005061 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 886882005062 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 886882005063 ligand binding site [chemical binding]; other site 886882005064 flexible hinge region; other site 886882005065 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 886882005066 putative switch regulator; other site 886882005067 non-specific DNA interactions [nucleotide binding]; other site 886882005068 DNA binding site [nucleotide binding] 886882005069 sequence specific DNA binding site [nucleotide binding]; other site 886882005070 putative cAMP binding site [chemical binding]; other site 886882005071 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 886882005072 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 886882005073 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 886882005074 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 886882005075 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882005076 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882005077 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 886882005078 dimerization interface [polypeptide binding]; other site 886882005079 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 886882005080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882005081 S-adenosylmethionine binding site [chemical binding]; other site 886882005082 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 886882005083 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 886882005084 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 886882005085 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 886882005086 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 886882005087 putative substrate binding site [chemical binding]; other site 886882005088 putative ATP binding site [chemical binding]; other site 886882005089 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 886882005090 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 886882005091 active site 886882005092 phosphorylation site [posttranslational modification] 886882005093 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 886882005094 active site 886882005095 P-loop; other site 886882005096 phosphorylation site [posttranslational modification] 886882005097 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 886882005098 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882005099 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882005100 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882005101 dimerization interface [polypeptide binding]; other site 886882005102 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 886882005103 transcriptional antiterminator BglG; Provisional; Region: PRK09772 886882005104 CAT RNA binding domain; Region: CAT_RBD; smart01061 886882005105 PRD domain; Region: PRD; pfam00874 886882005106 PRD domain; Region: PRD; pfam00874 886882005107 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 886882005108 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 886882005109 active site turn [active] 886882005110 phosphorylation site [posttranslational modification] 886882005111 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882005112 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 886882005113 HPr interaction site; other site 886882005114 glycerol kinase (GK) interaction site [polypeptide binding]; other site 886882005115 active site 886882005116 phosphorylation site [posttranslational modification] 886882005117 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 886882005118 beta-galactosidase; Region: BGL; TIGR03356 886882005119 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882005120 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882005121 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882005122 dimerization interface [polypeptide binding]; other site 886882005123 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 886882005124 substrate binding site [chemical binding]; other site 886882005125 THF binding site; other site 886882005126 zinc-binding site [ion binding]; other site 886882005127 putative transposase OrfB; Reviewed; Region: PHA02517 886882005128 HTH-like domain; Region: HTH_21; pfam13276 886882005129 Integrase core domain; Region: rve; pfam00665 886882005130 Integrase core domain; Region: rve_3; pfam13683 886882005131 Transposase; Region: HTH_Tnp_1; cl17663 886882005132 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 886882005133 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 886882005134 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882005135 NAD(P) binding site [chemical binding]; other site 886882005136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882005137 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 886882005138 active site 886882005139 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 886882005140 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 886882005141 GAD-like domain; Region: GAD-like; pfam08887 886882005142 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 886882005143 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 886882005144 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 886882005145 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 886882005146 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 886882005147 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 886882005148 DNA methylase; Region: N6_N4_Mtase; cl17433 886882005149 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882005150 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882005151 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 886882005152 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 886882005153 active site 886882005154 Int/Topo IB signature motif; other site 886882005155 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 886882005156 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882005157 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882005158 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 886882005159 YWTD domain; Region: YWTD; cl17223 886882005160 SMI1 / KNR4 family; Region: SMI1_KNR4; smart00860 886882005161 heat shock protein 90; Provisional; Region: PRK05218 886882005162 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882005163 ATP binding site [chemical binding]; other site 886882005164 Mg2+ binding site [ion binding]; other site 886882005165 G-X-G motif; other site 886882005166 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 886882005167 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 886882005168 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882005169 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 886882005170 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 886882005171 dimer interface [polypeptide binding]; other site 886882005172 active site 886882005173 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 886882005174 catalytic residues [active] 886882005175 substrate binding site [chemical binding]; other site 886882005176 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 886882005177 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 886882005178 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882005179 Coenzyme A binding pocket [chemical binding]; other site 886882005180 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 886882005181 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882005182 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882005183 dimerization interface [polypeptide binding]; other site 886882005184 putative DNA binding site [nucleotide binding]; other site 886882005185 putative Zn2+ binding site [ion binding]; other site 886882005186 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 886882005187 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 886882005188 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 886882005189 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 886882005190 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 886882005191 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 886882005192 active site 886882005193 metal binding site [ion binding]; metal-binding site 886882005194 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 886882005195 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882005196 DNA-binding site [nucleotide binding]; DNA binding site 886882005197 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 886882005198 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 886882005199 putative dimerization interface [polypeptide binding]; other site 886882005200 putative ligand binding site [chemical binding]; other site 886882005201 ribulokinase; Provisional; Region: PRK04123 886882005202 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 886882005203 non-specific DNA binding site [nucleotide binding]; other site 886882005204 salt bridge; other site 886882005205 sequence-specific DNA binding site [nucleotide binding]; other site 886882005206 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882005207 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 886882005208 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 886882005209 NodB motif; other site 886882005210 active site 886882005211 catalytic site [active] 886882005212 Zn binding site [ion binding]; other site 886882005213 Holin family; Region: Phage_holin_4; pfam05105 886882005214 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 886882005215 Uncharacterized conserved protein [Function unknown]; Region: COG2445 886882005216 iron-sulfur cluster biosynthesis transcriptional regulator SufR; Region: SufR_cyano; TIGR02702 886882005217 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 886882005218 putative DNA binding site [nucleotide binding]; other site 886882005219 putative Zn2+ binding site [ion binding]; other site 886882005220 YtxH-like protein; Region: YtxH; pfam12732 886882005221 glutamate racemase; Provisional; Region: PRK00865 886882005222 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 886882005223 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 886882005224 Peptidase M14 carboxypeptidase family-like domain of Endopeptidase I; Region: M14_Endopeptidase_I; cd06229 886882005225 putative active site [active] 886882005226 Zn binding site [ion binding]; other site 886882005227 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 886882005228 Protein of unknown function (DUF1450); Region: DUF1450; cl11488 886882005229 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 886882005230 Sulfatase; Region: Sulfatase; pfam00884 886882005231 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 886882005232 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 886882005233 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 886882005234 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 886882005235 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 886882005236 drug efflux system protein MdtG; Provisional; Region: PRK09874 886882005237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882005238 putative substrate translocation pore; other site 886882005239 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 886882005240 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 886882005241 substrate binding site [chemical binding]; other site 886882005242 active site 886882005243 ferrochelatase; Provisional; Region: PRK12435 886882005244 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 886882005245 C-terminal domain interface [polypeptide binding]; other site 886882005246 active site 886882005247 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 886882005248 active site 886882005249 N-terminal domain interface [polypeptide binding]; other site 886882005250 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 886882005251 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 886882005252 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 886882005253 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 886882005254 putative active site [active] 886882005255 putative metal binding site [ion binding]; other site 886882005256 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 886882005257 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 886882005258 active site 886882005259 catalytic site [active] 886882005260 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 886882005261 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 886882005262 Integral membrane protein DUF92; Region: DUF92; pfam01940 886882005263 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882005264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882005265 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 886882005266 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882005267 Walker A/P-loop; other site 886882005268 ATP binding site [chemical binding]; other site 886882005269 Q-loop/lid; other site 886882005270 ABC transporter signature motif; other site 886882005271 Walker B; other site 886882005272 D-loop; other site 886882005273 H-loop/switch region; other site 886882005274 ABC transporter; Region: ABC_tran_2; pfam12848 886882005275 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 886882005276 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 886882005277 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 886882005278 putative oligomer interface [polypeptide binding]; other site 886882005279 putative active site [active] 886882005280 metal binding site [ion binding]; metal-binding site 886882005281 Protein of unknown function (DUF1049); Region: DUF1049; cl01539 886882005282 oligoendopeptidase F; Region: pepF; TIGR00181 886882005283 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 886882005284 active site 886882005285 Zn binding site [ion binding]; other site 886882005286 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 886882005287 DNA-binding site [nucleotide binding]; DNA binding site 886882005288 RNA-binding motif; other site 886882005289 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 886882005290 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 886882005291 Protein of unknown function (DUF2600); Region: DUF2600; pfam10776 886882005292 6-phosphofructokinase; Provisional; Region: PRK03202 886882005293 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 886882005294 active site 886882005295 ADP/pyrophosphate binding site [chemical binding]; other site 886882005296 dimerization interface [polypeptide binding]; other site 886882005297 allosteric effector site; other site 886882005298 fructose-1,6-bisphosphate binding site; other site 886882005299 Protein of unknown function (DUF3906); Region: DUF3906; pfam13046 886882005300 multidrug efflux protein; Reviewed; Region: PRK01766 886882005301 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 886882005302 cation binding site [ion binding]; other site 886882005303 Putative glycosyl hydrolase domain; Region: DUF4015; pfam13200 886882005304 Uncharacterized conserved protein [Function unknown]; Region: COG1284 886882005305 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 886882005306 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 886882005307 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 886882005308 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 886882005309 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 886882005310 ATP binding site [chemical binding]; other site 886882005311 Mg++ binding site [ion binding]; other site 886882005312 motif III; other site 886882005313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882005314 nucleotide binding region [chemical binding]; other site 886882005315 ATP-binding site [chemical binding]; other site 886882005316 Protein of unknown function, DUF624; Region: DUF624; cl02369 886882005317 Protein of unknown function (DUF1499); Region: DUF1499; cl01841 886882005318 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 886882005319 dimer interface [polypeptide binding]; other site 886882005320 catalytic triad [active] 886882005321 peroxidatic and resolving cysteines [active] 886882005322 Rhomboid family; Region: Rhomboid; cl11446 886882005323 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882005324 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882005325 The substrate binding domain of LysR-type transcriptional regulator GltC, which activates gltA expression of glutamate synthase operon, contains type 2 periplasmic binding fold; Region: PBP2_GltC_like; cd08434 886882005326 putative dimerization interface [polypeptide binding]; other site 886882005327 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 886882005328 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 886882005329 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 886882005330 DNA binding residues [nucleotide binding] 886882005331 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 886882005332 Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905 886882005333 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 886882005334 metal binding triad; other site 886882005335 hypothetical protein; Provisional; Region: PRK07740 886882005336 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 886882005337 active site 886882005338 catalytic site [active] 886882005339 substrate binding site [chemical binding]; other site 886882005340 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 886882005341 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 886882005342 catalytic residues [active] 886882005343 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 886882005344 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 886882005345 active site 886882005346 catalytic residues [active] 886882005347 metal binding site [ion binding]; metal-binding site 886882005348 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 886882005349 DNA polymerase IV; Validated; Region: PRK01810 886882005350 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 886882005351 active site 886882005352 DNA binding site [nucleotide binding] 886882005353 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 886882005354 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 886882005355 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 886882005356 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 886882005357 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 886882005358 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 886882005359 quinone interaction residues [chemical binding]; other site 886882005360 active site 886882005361 catalytic residues [active] 886882005362 FMN binding site [chemical binding]; other site 886882005363 substrate binding site [chemical binding]; other site 886882005364 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 886882005365 synthetase active site [active] 886882005366 NTP binding site [chemical binding]; other site 886882005367 metal binding site [ion binding]; metal-binding site 886882005368 Domain of unknown function (DUF309); Region: DUF309; pfam03745 886882005369 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 886882005370 catalytic residues [active] 886882005371 NOL1/NOP2/sun family; Region: Nol1_Nop2_Fmu; pfam01189 886882005372 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 886882005373 Uncharacterized conserved protein [Function unknown]; Region: COG3270 886882005374 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 886882005375 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 886882005376 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 886882005377 RNA binding surface [nucleotide binding]; other site 886882005378 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 886882005379 active site 886882005380 uracil binding [chemical binding]; other site 886882005381 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 886882005382 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 886882005383 metal binding site [ion binding]; metal-binding site 886882005384 active site 886882005385 I-site; other site 886882005386 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 886882005387 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 886882005388 Uncharacterized membrane protein [Function unknown]; Region: COG3949 886882005389 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 886882005390 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 886882005391 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 886882005392 active site 886882005393 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 886882005394 methionine sulfoxide reductase A; Provisional; Region: PRK14054 886882005395 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 886882005396 NodB motif; other site 886882005397 putative active site [active] 886882005398 putative catalytic site [active] 886882005399 Zn binding site [ion binding]; other site 886882005400 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 886882005401 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 886882005402 active site 886882005403 metal binding site [ion binding]; metal-binding site 886882005404 YqzE-like protein; Region: YqzE; pfam14038 886882005405 Bacterial protein YqhG of unknown function; Region: YqhG; pfam11079 886882005406 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 886882005407 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 886882005408 ATP binding site [chemical binding]; other site 886882005409 putative Mg++ binding site [ion binding]; other site 886882005410 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882005411 nucleotide binding region [chemical binding]; other site 886882005412 ATP-binding site [chemical binding]; other site 886882005413 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882005414 salt bridge; other site 886882005415 non-specific DNA binding site [nucleotide binding]; other site 886882005416 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 886882005417 sequence-specific DNA binding site [nucleotide binding]; other site 886882005418 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 886882005419 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 886882005420 dimer interface [polypeptide binding]; other site 886882005421 active site 886882005422 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 886882005423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882005424 Coenzyme A binding pocket [chemical binding]; other site 886882005425 Predicted transcriptional regulator [Transcription]; Region: COG2378 886882005426 HTH domain; Region: HTH_11; pfam08279 886882005427 WYL domain; Region: WYL; pfam13280 886882005428 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 886882005429 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 886882005430 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 886882005431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882005432 putative substrate translocation pore; other site 886882005433 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882005434 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882005435 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 886882005436 putative ADP-ribose binding site [chemical binding]; other site 886882005437 putative active site [active] 886882005438 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 886882005439 nudix motif; other site 886882005440 hypothetical protein; Validated; Region: PRK07682 886882005441 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882005442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882005443 homodimer interface [polypeptide binding]; other site 886882005444 catalytic residue [active] 886882005445 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 886882005446 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 886882005447 Predicted transcriptional regulator [Transcription]; Region: COG4189 886882005448 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882005449 dimerization interface [polypeptide binding]; other site 886882005450 putative DNA binding site [nucleotide binding]; other site 886882005451 putative Zn2+ binding site [ion binding]; other site 886882005452 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882005453 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882005454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882005455 putative PBP binding loops; other site 886882005456 dimer interface [polypeptide binding]; other site 886882005457 ABC-ATPase subunit interface; other site 886882005458 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882005459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882005460 dimer interface [polypeptide binding]; other site 886882005461 conserved gate region; other site 886882005462 putative PBP binding loops; other site 886882005463 ABC-ATPase subunit interface; other site 886882005464 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 886882005465 substrate binding site [chemical binding]; other site 886882005466 active site 886882005467 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 886882005468 active site 886882005469 hypothetical protein; Provisional; Region: PRK06922 886882005470 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882005471 S-adenosylmethionine binding site [chemical binding]; other site 886882005472 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 886882005473 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 886882005474 dimer interface [polypeptide binding]; other site 886882005475 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 886882005476 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882005477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882005478 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882005479 putative substrate translocation pore; other site 886882005480 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 886882005481 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 886882005482 dimer interface [polypeptide binding]; other site 886882005483 putative radical transfer pathway; other site 886882005484 diiron center [ion binding]; other site 886882005485 tyrosyl radical; other site 886882005486 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07632 886882005487 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 886882005488 Class I ribonucleotide reductase; Region: RNR_I; cd01679 886882005489 active site 886882005490 dimer interface [polypeptide binding]; other site 886882005491 catalytic residues [active] 886882005492 effector binding site; other site 886882005493 R2 peptide binding site; other site 886882005494 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 886882005495 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 886882005496 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 886882005497 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 886882005498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882005499 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882005500 putative substrate translocation pore; other site 886882005501 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882005502 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882005503 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882005504 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882005505 DNA binding site [nucleotide binding] 886882005506 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 886882005507 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 886882005508 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 886882005509 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 886882005510 Protein of unknown function (DUF1361); Region: DUF1361; cl01784 886882005511 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 886882005512 Predicted membrane protein (DUF2238); Region: DUF2238; pfam09997 886882005513 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 886882005514 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 886882005515 Predicted membrane protein [Function unknown]; Region: COG4129 886882005516 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 886882005517 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 886882005518 Part of AAA domain; Region: AAA_19; pfam13245 886882005519 Family description; Region: UvrD_C_2; pfam13538 886882005520 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 886882005521 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 886882005522 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 886882005523 active site 886882005524 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 886882005525 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 886882005526 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 886882005527 ligand binding site [chemical binding]; other site 886882005528 flexible hinge region; other site 886882005529 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882005530 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882005531 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882005532 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 886882005533 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882005534 dimerization interface [polypeptide binding]; other site 886882005535 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882005536 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882005537 dimer interface [polypeptide binding]; other site 886882005538 putative CheW interface [polypeptide binding]; other site 886882005539 galactoside permease; Reviewed; Region: lacY; PRK09528 886882005540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882005541 putative substrate translocation pore; other site 886882005542 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 886882005543 Cupin domain; Region: Cupin_2; pfam07883 886882005544 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882005545 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882005546 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882005547 putative alpha-glucosidase; Provisional; Region: PRK10658 886882005548 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 886882005549 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 886882005550 active site 886882005551 homotrimer interface [polypeptide binding]; other site 886882005552 catalytic site [active] 886882005553 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 886882005554 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 886882005555 Beta-lactamase; Region: Beta-lactamase; pfam00144 886882005556 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 886882005557 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882005558 dimerization interface [polypeptide binding]; other site 886882005559 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882005560 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882005561 dimer interface [polypeptide binding]; other site 886882005562 putative CheW interface [polypeptide binding]; other site 886882005563 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882005564 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882005565 putative substrate translocation pore; other site 886882005566 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882005567 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882005568 putative substrate translocation pore; other site 886882005569 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882005570 MarR family; Region: MarR; pfam01047 886882005571 MarR family; Region: MarR_2; cl17246 886882005572 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 886882005573 active site 886882005574 intersubunit interactions; other site 886882005575 catalytic residue [active] 886882005576 HTH domain; Region: HTH_11; pfam08279 886882005577 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 886882005578 FOG: CBS domain [General function prediction only]; Region: COG0517 886882005579 TraX protein; Region: TraX; pfam05857 886882005580 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 886882005581 putative active site [active] 886882005582 putative metal binding site [ion binding]; other site 886882005583 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882005584 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 886882005585 acyl-activating enzyme (AAE) consensus motif; other site 886882005586 AMP binding site [chemical binding]; other site 886882005587 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882005588 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 886882005589 thioester reductase domain; Region: Thioester-redct; TIGR01746 886882005590 putative NAD(P) binding site [chemical binding]; other site 886882005591 active site 886882005592 putative substrate binding site [chemical binding]; other site 886882005593 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882005594 dimerization interface [polypeptide binding]; other site 886882005595 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882005596 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882005597 dimer interface [polypeptide binding]; other site 886882005598 putative CheW interface [polypeptide binding]; other site 886882005599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882005600 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 886882005601 Coenzyme A binding pocket [chemical binding]; other site 886882005602 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 886882005603 tetramer (dimer of dimers) interface [polypeptide binding]; other site 886882005604 active site 886882005605 dimer interface [polypeptide binding]; other site 886882005606 VanZ like family; Region: VanZ; pfam04892 886882005607 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882005608 MarR family; Region: MarR; pfam01047 886882005609 MarR family; Region: MarR_2; cl17246 886882005610 B12 binding domain; Region: B12-binding_2; pfam02607 886882005611 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 886882005612 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cd02065 886882005613 B12 binding site [chemical binding]; other site 886882005614 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882005615 dimer interface [polypeptide binding]; other site 886882005616 phosphorylation site [posttranslational modification] 886882005617 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882005618 ATP binding site [chemical binding]; other site 886882005619 Mg2+ binding site [ion binding]; other site 886882005620 G-X-G motif; other site 886882005621 Response regulator receiver domain; Region: Response_reg; pfam00072 886882005622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882005623 active site 886882005624 phosphorylation site [posttranslational modification] 886882005625 intermolecular recognition site; other site 886882005626 dimerization interface [polypeptide binding]; other site 886882005627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882005628 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882005629 putative substrate translocation pore; other site 886882005630 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 886882005631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882005632 Coenzyme A binding pocket [chemical binding]; other site 886882005633 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 886882005634 active site 886882005635 oxyanion hole [active] 886882005636 catalytic triad [active] 886882005637 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 886882005638 binding surface 886882005639 TPR motif; other site 886882005640 Uncharacterized conserved protein [Function unknown]; Region: COG5646 886882005641 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 886882005642 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 886882005643 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882005644 Bacterial SH3 domain homologues; Region: SH3b; smart00287 886882005645 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 886882005646 NlpC/P60 family; Region: NLPC_P60; pfam00877 886882005647 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 886882005648 lactaldehyde reductase; Region: lactal_redase; TIGR02638 886882005649 dimer interface [polypeptide binding]; other site 886882005650 active site 886882005651 metal binding site [ion binding]; metal-binding site 886882005652 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533 886882005653 homodimer interface [polypeptide binding]; other site 886882005654 metal binding site [ion binding]; metal-binding site 886882005655 MarR family; Region: MarR_2; pfam12802 886882005656 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 886882005657 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 886882005658 EDD domain protein, DegV family; Region: DegV; TIGR00762 886882005659 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 886882005660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882005661 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882005662 putative substrate translocation pore; other site 886882005663 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 886882005664 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 886882005665 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 886882005666 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 886882005667 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882005668 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882005669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882005670 Amino acid permease; Region: AA_permease_2; pfam13520 886882005671 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 886882005672 Accessory gene regulator B; Region: AgrB; pfam04647 886882005673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882005674 S-adenosylmethionine binding site [chemical binding]; other site 886882005675 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 886882005676 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 886882005677 active site 886882005678 (T/H)XGH motif; other site 886882005679 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 886882005680 Nucleoside recognition; Region: Gate; pfam07670 886882005681 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 886882005682 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 886882005683 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 886882005684 hypothetical protein; Provisional; Region: PRK13670 886882005685 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 886882005686 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 886882005687 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 886882005688 fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424 886882005689 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 886882005690 active site 2 [active] 886882005691 active site 1 [active] 886882005692 putative phosphate acyltransferase; Provisional; Region: PRK05331 886882005693 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 886882005694 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 886882005695 dimer interface [polypeptide binding]; other site 886882005696 active site 886882005697 CoA binding pocket [chemical binding]; other site 886882005698 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 886882005699 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 886882005700 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 886882005701 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 886882005702 NAD(P) binding site [chemical binding]; other site 886882005703 homotetramer interface [polypeptide binding]; other site 886882005704 homodimer interface [polypeptide binding]; other site 886882005705 active site 886882005706 acyl carrier protein; Provisional; Region: acpP; PRK00982 886882005707 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 886882005708 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 886882005709 dimer interface [polypeptide binding]; other site 886882005710 active site 886882005711 ribonuclease III; Reviewed; Region: rnc; PRK00102 886882005712 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 886882005713 dimerization interface [polypeptide binding]; other site 886882005714 active site 886882005715 metal binding site [ion binding]; metal-binding site 886882005716 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 886882005717 dsRNA binding site [nucleotide binding]; other site 886882005718 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 886882005719 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 886882005720 Walker A/P-loop; other site 886882005721 ATP binding site [chemical binding]; other site 886882005722 Q-loop/lid; other site 886882005723 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 886882005724 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 886882005725 ABC transporter signature motif; other site 886882005726 Walker B; other site 886882005727 D-loop; other site 886882005728 H-loop/switch region; other site 886882005729 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 886882005730 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 886882005731 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 886882005732 P loop; other site 886882005733 GTP binding site [chemical binding]; other site 886882005734 Haemolysin-III related; Region: HlyIII; cl03831 886882005735 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 886882005736 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 886882005737 putative DNA-binding protein; Validated; Region: PRK00118 886882005738 signal recognition particle protein; Provisional; Region: PRK10867 886882005739 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 886882005740 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 886882005741 P loop; other site 886882005742 GTP binding site [chemical binding]; other site 886882005743 Signal peptide binding domain; Region: SRP_SPB; pfam02978 886882005744 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 886882005745 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 886882005746 hypothetical protein; Provisional; Region: PRK00468 886882005747 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 886882005748 RimM N-terminal domain; Region: RimM; pfam01782 886882005749 PRC-barrel domain; Region: PRC; pfam05239 886882005750 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 886882005751 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 886882005752 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 886882005753 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 886882005754 Catalytic site [active] 886882005755 conjugal transfer pilin processing protease TraF; Provisional; Region: PRK13838 886882005756 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 886882005757 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 886882005758 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 886882005759 GTP/Mg2+ binding site [chemical binding]; other site 886882005760 G4 box; other site 886882005761 G5 box; other site 886882005762 G1 box; other site 886882005763 Switch I region; other site 886882005764 G2 box; other site 886882005765 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 886882005766 G3 box; other site 886882005767 Switch II region; other site 886882005768 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 886882005769 RNA/DNA hybrid binding site [nucleotide binding]; other site 886882005770 active site 886882005771 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 886882005772 hypothetical protein; Reviewed; Region: PRK12497 886882005773 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 886882005774 putative FMN binding site [chemical binding]; other site 886882005775 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 886882005776 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 886882005777 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 886882005778 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 886882005779 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 886882005780 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 886882005781 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 886882005782 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882005783 MarR family; Region: MarR; pfam01047 886882005784 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 886882005785 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 886882005786 CoA-ligase; Region: Ligase_CoA; pfam00549 886882005787 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 886882005788 CoA binding domain; Region: CoA_binding; smart00881 886882005789 CoA-ligase; Region: Ligase_CoA; pfam00549 886882005790 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 886882005791 DNA protecting protein DprA; Region: dprA; TIGR00732 886882005792 DNA topoisomerase I; Validated; Region: PRK05582 886882005793 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 886882005794 active site 886882005795 interdomain interaction site; other site 886882005796 putative metal-binding site [ion binding]; other site 886882005797 nucleotide binding site [chemical binding]; other site 886882005798 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 886882005799 domain I; other site 886882005800 DNA binding groove [nucleotide binding] 886882005801 phosphate binding site [ion binding]; other site 886882005802 domain II; other site 886882005803 domain III; other site 886882005804 nucleotide binding site [chemical binding]; other site 886882005805 catalytic site [active] 886882005806 domain IV; other site 886882005807 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 886882005808 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 886882005809 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 886882005810 Glucose inhibited division protein A; Region: GIDA; pfam01134 886882005811 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 886882005812 active site 886882005813 HslU subunit interaction site [polypeptide binding]; other site 886882005814 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 886882005815 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882005816 Walker A motif; other site 886882005817 ATP binding site [chemical binding]; other site 886882005818 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 886882005819 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 886882005820 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 886882005821 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 886882005822 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 886882005823 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 886882005824 Flagellar hook-basal body complex protein FliE; Region: FliE; cl09139 886882005825 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 886882005826 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 886882005827 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 886882005828 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 886882005829 FliG C-terminal domain; Region: FliG_C; pfam01706 886882005830 Flagellar assembly protein FliH; Region: FliH; pfam02108 886882005831 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07721 886882005832 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 886882005833 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 886882005834 Walker A motif/ATP binding site; other site 886882005835 Walker B motif; other site 886882005836 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 886882005837 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 886882005838 Uncharacterized conserved protein [Function unknown]; Region: COG3334 886882005839 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 886882005840 flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618 886882005841 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 886882005842 Protein of unknown function (DUF3766); Region: DUF3766; cl11797 886882005843 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636 886882005844 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 886882005845 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 886882005846 Flagellar protein (FlbD); Region: FlbD; pfam06289 886882005847 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 886882005848 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 886882005849 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 886882005850 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 886882005851 CheC-like family; Region: CheC; pfam04509 886882005852 flagellar motor switch protein FliN; Region: fliN; TIGR02480 886882005853 Response regulator receiver domain; Region: Response_reg; pfam00072 886882005854 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882005855 active site 886882005856 phosphorylation site [posttranslational modification] 886882005857 intermolecular recognition site; other site 886882005858 dimerization interface [polypeptide binding]; other site 886882005859 Flagellar biosynthesis protein, FliO; Region: FliO; cl01247 886882005860 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 886882005861 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 886882005862 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 886882005863 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 886882005864 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 886882005865 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 886882005866 FHIPEP family; Region: FHIPEP; pfam00771 886882005867 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 886882005868 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 886882005869 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 886882005870 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 886882005871 P-loop; other site 886882005872 Response regulator receiver domain; Region: Response_reg; pfam00072 886882005873 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882005874 active site 886882005875 phosphorylation site [posttranslational modification] 886882005876 intermolecular recognition site; other site 886882005877 dimerization interface [polypeptide binding]; other site 886882005878 CheB methylesterase; Region: CheB_methylest; pfam01339 886882005879 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 886882005880 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 886882005881 putative binding surface; other site 886882005882 active site 886882005883 P2 response regulator binding domain; Region: P2; pfam07194 886882005884 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 886882005885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882005886 ATP binding site [chemical binding]; other site 886882005887 Mg2+ binding site [ion binding]; other site 886882005888 G-X-G motif; other site 886882005889 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 886882005890 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 886882005891 putative CheA interaction surface; other site 886882005892 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 886882005893 CheC-like family; Region: CheC; pfam04509 886882005894 CheC-like family; Region: CheC; pfam04509 886882005895 Chemotaxis protein; stimulates methylation of MCP proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheD; COG1871 886882005896 RNA polymerase sigma factor SigD; Validated; Region: PRK07670 886882005897 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882005898 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 886882005899 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882005900 DNA binding residues [nucleotide binding] 886882005901 Protein of unknown function (DUF342); Region: DUF342; pfam03961 886882005902 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 886882005903 YceG-like family; Region: YceG; pfam02618 886882005904 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 886882005905 rRNA interaction site [nucleotide binding]; other site 886882005906 S8 interaction site; other site 886882005907 putative laminin-1 binding site; other site 886882005908 elongation factor Ts; Reviewed; Region: tsf; PRK12332 886882005909 UBA/TS-N domain; Region: UBA; pfam00627 886882005910 Elongation factor TS; Region: EF_TS; pfam00889 886882005911 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 886882005912 putative nucleotide binding site [chemical binding]; other site 886882005913 uridine monophosphate binding site [chemical binding]; other site 886882005914 homohexameric interface [polypeptide binding]; other site 886882005915 ribosome recycling factor; Reviewed; Region: frr; PRK00083 886882005916 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 886882005917 hinge region; other site 886882005918 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 886882005919 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 886882005920 catalytic residue [active] 886882005921 putative FPP diphosphate binding site; other site 886882005922 putative FPP binding hydrophobic cleft; other site 886882005923 dimer interface [polypeptide binding]; other site 886882005924 putative IPP diphosphate binding site; other site 886882005925 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 886882005926 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 886882005927 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 886882005928 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 886882005929 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 886882005930 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 886882005931 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 886882005932 RIP metalloprotease RseP; Region: TIGR00054 886882005933 active site 886882005934 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 886882005935 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 886882005936 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 886882005937 putative substrate binding region [chemical binding]; other site 886882005938 prolyl-tRNA synthetase; Provisional; Region: PRK08661 886882005939 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 886882005940 dimer interface [polypeptide binding]; other site 886882005941 motif 1; other site 886882005942 active site 886882005943 motif 2; other site 886882005944 motif 3; other site 886882005945 ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862 886882005946 anticodon binding site; other site 886882005947 zinc-binding site [ion binding]; other site 886882005948 DNA polymerase III PolC; Validated; Region: polC; PRK00448 886882005949 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 886882005950 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 886882005951 generic binding surface II; other site 886882005952 generic binding surface I; other site 886882005953 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 886882005954 active site 886882005955 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 886882005956 active site 886882005957 catalytic site [active] 886882005958 substrate binding site [chemical binding]; other site 886882005959 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 886882005960 ribosome maturation protein RimP; Reviewed; Region: PRK00092 886882005961 Sm and related proteins; Region: Sm_like; cl00259 886882005962 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 886882005963 putative oligomer interface [polypeptide binding]; other site 886882005964 putative RNA binding site [nucleotide binding]; other site 886882005965 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 886882005966 NusA N-terminal domain; Region: NusA_N; pfam08529 886882005967 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 886882005968 RNA binding site [nucleotide binding]; other site 886882005969 homodimer interface [polypeptide binding]; other site 886882005970 NusA-like KH domain; Region: KH_5; pfam13184 886882005971 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 886882005972 G-X-X-G motif; other site 886882005973 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 886882005974 putative RNA binding cleft [nucleotide binding]; other site 886882005975 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 886882005976 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 886882005977 translation initiation factor IF-2; Region: IF-2; TIGR00487 886882005978 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 886882005979 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 886882005980 G1 box; other site 886882005981 putative GEF interaction site [polypeptide binding]; other site 886882005982 GTP/Mg2+ binding site [chemical binding]; other site 886882005983 Switch I region; other site 886882005984 G2 box; other site 886882005985 G3 box; other site 886882005986 Switch II region; other site 886882005987 G4 box; other site 886882005988 G5 box; other site 886882005989 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 886882005990 Translation-initiation factor 2; Region: IF-2; pfam11987 886882005991 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 886882005992 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 886882005993 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 886882005994 DHH family; Region: DHH; pfam01368 886882005995 DHHA1 domain; Region: DHHA1; pfam02272 886882005996 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 886882005997 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 886882005998 RNA binding site [nucleotide binding]; other site 886882005999 active site 886882006000 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 886882006001 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 886882006002 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 886882006003 active site 886882006004 Riboflavin kinase; Region: Flavokinase; smart00904 886882006005 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 886882006006 16S/18S rRNA binding site [nucleotide binding]; other site 886882006007 S13e-L30e interaction site [polypeptide binding]; other site 886882006008 25S rRNA binding site [nucleotide binding]; other site 886882006009 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 886882006010 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 886882006011 RNase E interface [polypeptide binding]; other site 886882006012 trimer interface [polypeptide binding]; other site 886882006013 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 886882006014 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 886882006015 RNase E interface [polypeptide binding]; other site 886882006016 trimer interface [polypeptide binding]; other site 886882006017 active site 886882006018 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 886882006019 putative nucleic acid binding region [nucleotide binding]; other site 886882006020 G-X-X-G motif; other site 886882006021 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 886882006022 RNA binding site [nucleotide binding]; other site 886882006023 domain interface; other site 886882006024 probable sporulation protein, polysaccharide deacetylase family; Region: spore_ylxY; TIGR02873 886882006025 Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950 886882006026 NodB motif; other site 886882006027 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 886882006028 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 886882006029 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 886882006030 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 886882006031 trimer interface [polypeptide binding]; other site 886882006032 active site 886882006033 dipicolinate synthase subunit A; Reviewed; Region: PRK08306 886882006034 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 886882006035 NAD binding site [chemical binding]; other site 886882006036 dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305 886882006037 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 886882006038 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 886882006039 aspartate kinase I; Reviewed; Region: PRK08210 886882006040 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 886882006041 nucleotide binding site [chemical binding]; other site 886882006042 substrate binding site [chemical binding]; other site 886882006043 ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914 886882006044 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 886882006045 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 886882006046 dihydrodipicolinate synthase; Region: dapA; TIGR00674 886882006047 dimer interface [polypeptide binding]; other site 886882006048 active site 886882006049 catalytic residue [active] 886882006050 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 886882006051 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 886882006052 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 886882006053 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 886882006054 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 886882006055 active site 886882006056 YlzJ-like protein; Region: YlzJ; pfam14035 886882006057 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 886882006058 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 886882006059 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 886882006060 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 886882006061 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 886882006062 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 886882006063 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 886882006064 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 886882006065 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 886882006066 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 886882006067 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 886882006068 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 886882006069 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 886882006070 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882006071 NAD(P) binding site [chemical binding]; other site 886882006072 active site 886882006073 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 886882006074 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 886882006075 Protein of unknown function (DUF3388); Region: DUF3388; pfam11868 886882006076 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 886882006077 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882006078 non-specific DNA binding site [nucleotide binding]; other site 886882006079 salt bridge; other site 886882006080 sequence-specific DNA binding site [nucleotide binding]; other site 886882006081 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 886882006082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 886882006083 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 886882006084 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 886882006085 competence damage-inducible protein A; Provisional; Region: PRK00549 886882006086 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 886882006087 putative MPT binding site; other site 886882006088 Competence-damaged protein; Region: CinA; pfam02464 886882006089 recombinase A; Provisional; Region: recA; PRK09354 886882006090 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 886882006091 hexamer interface [polypeptide binding]; other site 886882006092 Walker A motif; other site 886882006093 ATP binding site [chemical binding]; other site 886882006094 Walker B motif; other site 886882006095 recombination regulator RecX; Reviewed; Region: recX; PRK00117 886882006096 Domain of unknown function (DUF3552); Region: DUF3552; pfam12072 886882006097 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 886882006098 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882006099 Zn2+ binding site [ion binding]; other site 886882006100 Mg2+ binding site [ion binding]; other site 886882006101 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 886882006102 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 886882006103 putative active site [active] 886882006104 metal binding site [ion binding]; metal-binding site 886882006105 homodimer binding site [polypeptide binding]; other site 886882006106 Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232 886882006107 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 886882006108 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 886882006109 active site 886882006110 dimer interface [polypeptide binding]; other site 886882006111 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 886882006112 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 886882006113 Propanediol utilisation protein PduL; Region: PduL; pfam06130 886882006114 Propanediol utilisation protein PduL; Region: PduL; pfam06130 886882006115 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14327 886882006116 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 886882006117 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882006118 FeS/SAM binding site; other site 886882006119 Protein of unknown function (DUF964); Region: DUF964; cl01483 886882006120 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 886882006121 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 886882006122 CoenzymeA binding site [chemical binding]; other site 886882006123 subunit interaction site [polypeptide binding]; other site 886882006124 PHB binding site; other site 886882006125 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 886882006126 nudix motif; other site 886882006127 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 886882006128 Isochorismatase family; Region: Isochorismatase; pfam00857 886882006129 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 886882006130 catalytic triad [active] 886882006131 conserved cis-peptide bond; other site 886882006132 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 886882006133 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 886882006134 active site 886882006135 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 886882006136 MPT binding site; other site 886882006137 trimer interface [polypeptide binding]; other site 886882006138 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 886882006139 dimerization interface [polypeptide binding]; other site 886882006140 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 886882006141 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 886882006142 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 886882006143 active site 886882006144 HIGH motif; other site 886882006145 KMSK motif region; other site 886882006146 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 886882006147 tRNA binding surface [nucleotide binding]; other site 886882006148 anticodon binding site; other site 886882006149 S-layer homology domain; Region: SLH; pfam00395 886882006150 PrcB C-terminal; Region: PrcB_C; pfam14343 886882006151 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882006152 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882006153 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 886882006154 Walker A/P-loop; other site 886882006155 ATP binding site [chemical binding]; other site 886882006156 Q-loop/lid; other site 886882006157 ABC transporter signature motif; other site 886882006158 Walker B; other site 886882006159 D-loop; other site 886882006160 H-loop/switch region; other site 886882006161 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882006162 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 886882006163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882006164 Walker A/P-loop; other site 886882006165 ATP binding site [chemical binding]; other site 886882006166 Q-loop/lid; other site 886882006167 ABC transporter signature motif; other site 886882006168 Walker B; other site 886882006169 D-loop; other site 886882006170 H-loop/switch region; other site 886882006171 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4841 886882006172 Predicted membrane protein [Function unknown]; Region: COG2707 886882006173 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 886882006174 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 886882006175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882006176 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882006177 putative DNA binding site [nucleotide binding]; other site 886882006178 dimerization interface [polypeptide binding]; other site 886882006179 putative Zn2+ binding site [ion binding]; other site 886882006180 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; cl01589 886882006181 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 886882006182 ribosome small subunit-dependent GTPase A; Region: TIGR00157 886882006183 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 886882006184 GTPase/Zn-binding domain interface [polypeptide binding]; other site 886882006185 GTP/Mg2+ binding site [chemical binding]; other site 886882006186 G4 box; other site 886882006187 G5 box; other site 886882006188 G1 box; other site 886882006189 Switch I region; other site 886882006190 G2 box; other site 886882006191 G3 box; other site 886882006192 Switch II region; other site 886882006193 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 886882006194 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 886882006195 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 886882006196 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 886882006197 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 886882006198 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 886882006199 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 886882006200 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 886882006201 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 886882006202 metal ion-dependent adhesion site (MIDAS); other site 886882006203 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 886882006204 active site 886882006205 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 886882006206 classical (c) SDRs; Region: SDR_c; cd05233 886882006207 NAD(P) binding site [chemical binding]; other site 886882006208 active site 886882006209 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882006210 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 886882006211 ATP binding site [chemical binding]; other site 886882006212 Chloramphenicol (Cm) binding site [chemical binding]; other site 886882006213 hypothetical protein; Provisional; Region: PRK06761 886882006214 Domain of unknown function (DUF4181); Region: DUF4181; pfam13789 886882006215 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882006216 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882006217 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882006218 translocation protein TolB; Provisional; Region: tolB; PRK04922 886882006219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882006220 salt bridge; other site 886882006221 non-specific DNA binding site [nucleotide binding]; other site 886882006222 sequence-specific DNA binding site [nucleotide binding]; other site 886882006223 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 886882006224 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 886882006225 Domain of unknown function (DUF1992); Region: DUF1992; cl08096 886882006226 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 886882006227 active site 886882006228 KMSKS motif; other site 886882006229 ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970 886882006230 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 886882006231 ATP binding site [chemical binding]; other site 886882006232 putative Mg++ binding site [ion binding]; other site 886882006233 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882006234 nucleotide binding region [chemical binding]; other site 886882006235 ATP-binding site [chemical binding]; other site 886882006236 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 886882006237 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 886882006238 Heat induced stress protein YflT; Region: YflT; pfam11181 886882006239 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 886882006240 Acyltransferase family; Region: Acyl_transf_3; pfam01757 886882006241 Replication terminator protein; Region: RTP; pfam02334 886882006242 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 886882006243 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882006244 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 886882006245 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 886882006246 DivIVA protein; Region: DivIVA; pfam05103 886882006247 DivIVA domain; Region: DivI1A_domain; TIGR03544 886882006248 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 886882006249 Rrf2 family protein; Region: rrf2_super; TIGR00738 886882006250 Transcriptional regulator; Region: Rrf2; pfam02082 886882006251 Transcriptional regulator; Region: Rrf2; cl17282 886882006252 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 886882006253 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 886882006254 active site 886882006255 metal binding site [ion binding]; metal-binding site 886882006256 homotetramer interface [polypeptide binding]; other site 886882006257 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 886882006258 dimer interface [polypeptide binding]; other site 886882006259 [2Fe-2S] cluster binding site [ion binding]; other site 886882006260 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 886882006261 dimer interface [polypeptide binding]; other site 886882006262 FMN binding site [chemical binding]; other site 886882006263 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 886882006264 cobyric acid synthase; Provisional; Region: PRK00784 886882006265 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 886882006266 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882006267 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 886882006268 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 886882006269 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 886882006270 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 886882006271 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 886882006272 Uncharacterized conserved protein [Function unknown]; Region: COG2135 886882006273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882006274 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882006275 putative substrate translocation pore; other site 886882006276 OsmC-like protein; Region: OsmC; cl00767 886882006277 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 886882006278 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 886882006279 azoreductase; Provisional; Region: PRK13556 886882006280 glutamate racemase; Provisional; Region: PRK00865 886882006281 Phosphotransferase enzyme family; Region: APH; pfam01636 886882006282 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 886882006283 fosfomycin resistance protein FosB; Provisional; Region: PRK04101 886882006284 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 886882006285 active site 886882006286 metal binding site [ion binding]; metal-binding site 886882006287 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 886882006288 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 886882006289 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 886882006290 active site 886882006291 catalytic residues [active] 886882006292 Tetratrico peptide repeat; Region: TPR_5; pfam12688 886882006293 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 886882006294 acetolactate synthase; Reviewed; Region: PRK08617 886882006295 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 886882006296 PYR/PP interface [polypeptide binding]; other site 886882006297 dimer interface [polypeptide binding]; other site 886882006298 TPP binding site [chemical binding]; other site 886882006299 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 886882006300 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 886882006301 TPP-binding site [chemical binding]; other site 886882006302 dimer interface [polypeptide binding]; other site 886882006303 Glucuronate isomerase; Region: UxaC; pfam02614 886882006304 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 886882006305 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 886882006306 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882006307 putative substrate translocation pore; other site 886882006308 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882006309 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882006310 DNA binding site [nucleotide binding] 886882006311 domain linker motif; other site 886882006312 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 886882006313 dimerization interface [polypeptide binding]; other site 886882006314 ligand binding site [chemical binding]; other site 886882006315 pyruvate dehydrogenase; Provisional; Region: PRK09124 886882006316 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 886882006317 PYR/PP interface [polypeptide binding]; other site 886882006318 dimer interface [polypeptide binding]; other site 886882006319 tetramer interface [polypeptide binding]; other site 886882006320 TPP binding site [chemical binding]; other site 886882006321 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 886882006322 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 886882006323 TPP-binding site [chemical binding]; other site 886882006324 altronate oxidoreductase; Provisional; Region: PRK03643 886882006325 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 886882006326 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 886882006327 galactarate dehydratase; Region: galactar-dH20; TIGR03248 886882006328 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 886882006329 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 886882006330 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 886882006331 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882006332 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 886882006333 Coenzyme A binding pocket [chemical binding]; other site 886882006334 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882006335 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882006336 dimer interface [polypeptide binding]; other site 886882006337 conserved gate region; other site 886882006338 ABC-ATPase subunit interface; other site 886882006339 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882006340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882006341 dimer interface [polypeptide binding]; other site 886882006342 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 886882006343 ABC-ATPase subunit interface; other site 886882006344 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882006345 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 886882006346 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882006347 dimerization interface [polypeptide binding]; other site 886882006348 Histidine kinase; Region: His_kinase; pfam06580 886882006349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882006350 ATP binding site [chemical binding]; other site 886882006351 Mg2+ binding site [ion binding]; other site 886882006352 G-X-G motif; other site 886882006353 Response regulator receiver domain; Region: Response_reg; pfam00072 886882006354 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882006355 active site 886882006356 phosphorylation site [posttranslational modification] 886882006357 intermolecular recognition site; other site 886882006358 dimerization interface [polypeptide binding]; other site 886882006359 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882006360 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882006361 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882006362 Protein of unknown function (DUF3891); Region: DUF3891; pfam13030 886882006363 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 886882006364 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 886882006365 ligand binding site; other site 886882006366 oligomer interface; other site 886882006367 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 886882006368 dimer interface [polypeptide binding]; other site 886882006369 N-terminal domain interface [polypeptide binding]; other site 886882006370 sulfate 1 binding site; other site 886882006371 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 886882006372 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 886882006373 ligand binding site; other site 886882006374 oligomer interface; other site 886882006375 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 886882006376 dimer interface [polypeptide binding]; other site 886882006377 N-terminal domain interface [polypeptide binding]; other site 886882006378 sulfate 1 binding site; other site 886882006379 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 886882006380 homodimer interface [polypeptide binding]; other site 886882006381 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 886882006382 active site pocket [active] 886882006383 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 886882006384 Predicted membrane protein [Function unknown]; Region: COG1511 886882006385 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 886882006386 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 886882006387 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 886882006388 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 886882006389 active site 886882006390 catalytic tetrad [active] 886882006391 Multidrug resistance efflux transporter; Region: EmrE; pfam13536 886882006392 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 886882006393 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 886882006394 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 886882006395 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882006396 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882006397 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882006398 dimerization interface [polypeptide binding]; other site 886882006399 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 886882006400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882006401 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 886882006402 Walker A/P-loop; other site 886882006403 ATP binding site [chemical binding]; other site 886882006404 Q-loop/lid; other site 886882006405 ABC transporter signature motif; other site 886882006406 Walker B; other site 886882006407 D-loop; other site 886882006408 H-loop/switch region; other site 886882006409 ABC-2 type transporter; Region: ABC2_membrane; cl17235 886882006410 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 886882006411 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882006412 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882006413 active site 886882006414 phosphorylation site [posttranslational modification] 886882006415 intermolecular recognition site; other site 886882006416 dimerization interface [polypeptide binding]; other site 886882006417 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882006418 DNA binding site [nucleotide binding] 886882006419 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882006420 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882006421 dimer interface [polypeptide binding]; other site 886882006422 phosphorylation site [posttranslational modification] 886882006423 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882006424 ATP binding site [chemical binding]; other site 886882006425 Mg2+ binding site [ion binding]; other site 886882006426 G-X-G motif; other site 886882006427 DinB superfamily; Region: DinB_2; pfam12867 886882006428 Predicted membrane protein [Function unknown]; Region: COG2323 886882006429 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 886882006430 catalytic residues [active] 886882006431 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 886882006432 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 886882006433 active site 886882006434 non-prolyl cis peptide bond; other site 886882006435 FMN reductase, SsuE family; Region: FMN_reduc_SsuE; TIGR03567 886882006436 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 886882006437 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882006438 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882006439 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882006440 dimerization interface [polypeptide binding]; other site 886882006441 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 886882006442 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 886882006443 substrate binding pocket [chemical binding]; other site 886882006444 membrane-bound complex binding site; other site 886882006445 hinge residues; other site 886882006446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882006447 dimer interface [polypeptide binding]; other site 886882006448 conserved gate region; other site 886882006449 putative PBP binding loops; other site 886882006450 ABC-ATPase subunit interface; other site 886882006451 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 886882006452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882006453 dimer interface [polypeptide binding]; other site 886882006454 conserved gate region; other site 886882006455 putative PBP binding loops; other site 886882006456 ABC-ATPase subunit interface; other site 886882006457 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 886882006458 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 886882006459 Walker A/P-loop; other site 886882006460 ATP binding site [chemical binding]; other site 886882006461 Q-loop/lid; other site 886882006462 ABC transporter signature motif; other site 886882006463 Walker B; other site 886882006464 D-loop; other site 886882006465 H-loop/switch region; other site 886882006466 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 886882006467 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 886882006468 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 886882006469 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 886882006470 metal binding site [ion binding]; metal-binding site 886882006471 dimer interface [polypeptide binding]; other site 886882006472 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 886882006473 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 886882006474 Transposase; Region: DDE_Tnp_ISL3; pfam01610 886882006475 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882006476 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 886882006477 putative substrate translocation pore; other site 886882006478 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882006479 putative DNA binding site [nucleotide binding]; other site 886882006480 putative Zn2+ binding site [ion binding]; other site 886882006481 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882006482 dimerization interface [polypeptide binding]; other site 886882006483 putative DNA binding site [nucleotide binding]; other site 886882006484 putative Zn2+ binding site [ion binding]; other site 886882006485 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 886882006486 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 886882006487 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 886882006488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882006489 dimer interface [polypeptide binding]; other site 886882006490 conserved gate region; other site 886882006491 putative PBP binding loops; other site 886882006492 ABC-ATPase subunit interface; other site 886882006493 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 886882006494 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 886882006495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882006496 dimer interface [polypeptide binding]; other site 886882006497 conserved gate region; other site 886882006498 putative PBP binding loops; other site 886882006499 ABC-ATPase subunit interface; other site 886882006500 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 886882006501 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 886882006502 Walker A/P-loop; other site 886882006503 ATP binding site [chemical binding]; other site 886882006504 Q-loop/lid; other site 886882006505 ABC transporter signature motif; other site 886882006506 Walker B; other site 886882006507 D-loop; other site 886882006508 H-loop/switch region; other site 886882006509 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 886882006510 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 886882006511 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 886882006512 Walker A/P-loop; other site 886882006513 ATP binding site [chemical binding]; other site 886882006514 Q-loop/lid; other site 886882006515 ABC transporter signature motif; other site 886882006516 Walker B; other site 886882006517 D-loop; other site 886882006518 H-loop/switch region; other site 886882006519 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 886882006520 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 886882006521 Cation efflux family; Region: Cation_efflux; pfam01545 886882006522 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 886882006523 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 886882006524 Predicted membrane protein/domain [Function unknown]; Region: COG1714 886882006525 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 886882006526 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 886882006527 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 886882006528 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 886882006529 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 886882006530 dimer interface [polypeptide binding]; other site 886882006531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882006532 catalytic residue [active] 886882006533 cystathionine beta-lyase; Provisional; Region: PRK07671 886882006534 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 886882006535 homodimer interface [polypeptide binding]; other site 886882006536 substrate-cofactor binding pocket; other site 886882006537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882006538 catalytic residue [active] 886882006539 Predicted esterase [General function prediction only]; Region: COG0400 886882006540 Nucleolar RNA-binding protein, Nop10p family; Region: Nop10p; cl00977 886882006541 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 886882006542 metal ion-dependent adhesion site (MIDAS); other site 886882006543 Tubulin like; Region: Tubulin_2; pfam13809 886882006544 Tubulin like; Region: Tubulin_2; pfam13809 886882006545 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 886882006546 metal ion-dependent adhesion site (MIDAS); other site 886882006547 Transcriptional regulators [Transcription]; Region: MarR; COG1846 886882006548 MarR family; Region: MarR_2; pfam12802 886882006549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882006550 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882006551 putative substrate translocation pore; other site 886882006552 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882006553 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 886882006554 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 886882006555 S-layer homology domain; Region: SLH; pfam00395 886882006556 S-layer homology domain; Region: SLH; pfam00395 886882006557 flagellin; Validated; Region: PRK08026 886882006558 S-layer homology domain; Region: SLH; pfam00395 886882006559 S-layer homology domain; Region: SLH; pfam00395 886882006560 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 886882006561 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 886882006562 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 886882006563 TIGR03943 family protein; Region: TIGR03943 886882006564 Predicted permeases [General function prediction only]; Region: COG0701 886882006565 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 886882006566 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 886882006567 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 886882006568 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 886882006569 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882006570 ABC-ATPase subunit interface; other site 886882006571 dimer interface [polypeptide binding]; other site 886882006572 putative PBP binding regions; other site 886882006573 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 886882006574 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 886882006575 Walker A/P-loop; other site 886882006576 ATP binding site [chemical binding]; other site 886882006577 Q-loop/lid; other site 886882006578 ABC transporter signature motif; other site 886882006579 Walker B; other site 886882006580 D-loop; other site 886882006581 H-loop/switch region; other site 886882006582 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 886882006583 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 886882006584 putative ligand binding residues [chemical binding]; other site 886882006585 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 886882006586 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 886882006587 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 886882006588 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882006589 ABC-ATPase subunit interface; other site 886882006590 dimer interface [polypeptide binding]; other site 886882006591 putative PBP binding regions; other site 886882006592 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 886882006593 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 886882006594 metal binding site [ion binding]; metal-binding site 886882006595 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 886882006596 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 886882006597 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882006598 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 886882006599 Walker A/P-loop; other site 886882006600 ATP binding site [chemical binding]; other site 886882006601 Q-loop/lid; other site 886882006602 ABC transporter signature motif; other site 886882006603 Walker B; other site 886882006604 D-loop; other site 886882006605 H-loop/switch region; other site 886882006606 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882006607 MarR family; Region: MarR_2; pfam12802 886882006608 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882006609 Response regulator receiver domain; Region: Response_reg; pfam00072 886882006610 active site 886882006611 phosphorylation site [posttranslational modification] 886882006612 intermolecular recognition site; other site 886882006613 dimerization interface [polypeptide binding]; other site 886882006614 Ycf1; Region: Ycf1; pfam05758 886882006615 WYL domain; Region: WYL; cl14852 886882006616 YolD-like protein; Region: YolD; pfam08863 886882006617 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 886882006618 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 886882006619 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 886882006620 S-layer homology domain; Region: SLH; pfam00395 886882006621 S-layer homology domain; Region: SLH; pfam00395 886882006622 S-layer homology domain; Region: SLH; pfam00395 886882006623 Methyltransferase domain; Region: Methyltransf_31; pfam13847 886882006624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882006625 S-adenosylmethionine binding site [chemical binding]; other site 886882006626 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 886882006627 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 886882006628 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 886882006629 active site 886882006630 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 886882006631 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 886882006632 active site 886882006633 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 886882006634 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 886882006635 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 886882006636 catalytic residue [active] 886882006637 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 886882006638 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 886882006639 putative trimer interface [polypeptide binding]; other site 886882006640 putative CoA binding site [chemical binding]; other site 886882006641 short chain dehydrogenase; Validated; Region: PRK08324 886882006642 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 886882006643 active site 886882006644 intersubunit interface [polypeptide binding]; other site 886882006645 Zn2+ binding site [ion binding]; other site 886882006646 rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943 886882006647 putative NAD(P) binding site [chemical binding]; other site 886882006648 active site 886882006649 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 886882006650 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 886882006651 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 886882006652 N- and C-terminal domain interface [polypeptide binding]; other site 886882006653 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 886882006654 active site 886882006655 putative catalytic site [active] 886882006656 metal binding site [ion binding]; metal-binding site 886882006657 ATP binding site [chemical binding]; other site 886882006658 carbohydrate binding site [chemical binding]; other site 886882006659 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 886882006660 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 886882006661 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 886882006662 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 886882006663 Cysteine-rich domain; Region: CCG; pfam02754 886882006664 Cysteine-rich domain; Region: CCG; pfam02754 886882006665 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 886882006666 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 886882006667 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 886882006668 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 886882006669 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 886882006670 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 886882006671 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882006672 dimerization interface [polypeptide binding]; other site 886882006673 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882006674 dimer interface [polypeptide binding]; other site 886882006675 phosphorylation site [posttranslational modification] 886882006676 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882006677 ATP binding site [chemical binding]; other site 886882006678 Mg2+ binding site [ion binding]; other site 886882006679 G-X-G motif; other site 886882006680 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882006681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882006682 active site 886882006683 phosphorylation site [posttranslational modification] 886882006684 intermolecular recognition site; other site 886882006685 dimerization interface [polypeptide binding]; other site 886882006686 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882006687 DNA binding site [nucleotide binding] 886882006688 Acyltransferase family; Region: Acyl_transf_3; pfam01757 886882006689 CHRD domain; Region: CHRD; pfam07452 886882006690 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 886882006691 active site 886882006692 catalytic triad [active] 886882006693 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 886882006694 DNA binding site [nucleotide binding] 886882006695 active site 886882006696 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 886882006697 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 886882006698 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 886882006699 HlyD family secretion protein; Region: HlyD_3; pfam13437 886882006700 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 886882006701 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 886882006702 Walker A/P-loop; other site 886882006703 ATP binding site [chemical binding]; other site 886882006704 Q-loop/lid; other site 886882006705 ABC transporter signature motif; other site 886882006706 Walker B; other site 886882006707 D-loop; other site 886882006708 H-loop/switch region; other site 886882006709 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 886882006710 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 886882006711 FtsX-like permease family; Region: FtsX; pfam02687 886882006712 HTH domain; Region: HTH_11; pfam08279 886882006713 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 886882006714 FOG: CBS domain [General function prediction only]; Region: COG0517 886882006715 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 886882006716 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 886882006717 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 886882006718 putative active site [active] 886882006719 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 886882006720 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882006721 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 886882006722 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 886882006723 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 886882006724 acyl-activating enzyme (AAE) consensus motif; other site 886882006725 AMP binding site [chemical binding]; other site 886882006726 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882006727 Condensation domain; Region: Condensation; pfam00668 886882006728 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882006729 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882006730 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 886882006731 acyl-activating enzyme (AAE) consensus motif; other site 886882006732 AMP binding site [chemical binding]; other site 886882006733 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882006734 Condensation domain; Region: Condensation; pfam00668 886882006735 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882006736 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882006737 Condensation domain; Region: Condensation; pfam00668 886882006738 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882006739 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882006740 acyl-activating enzyme (AAE) consensus motif; other site 886882006741 AMP binding site [chemical binding]; other site 886882006742 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882006743 Thioesterase domain; Region: Thioesterase; pfam00975 886882006744 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 886882006745 Beta-lactamase; Region: Beta-lactamase; pfam00144 886882006746 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 886882006747 generic binding surface II; other site 886882006748 generic binding surface I; other site 886882006749 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 886882006750 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 886882006751 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 886882006752 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 886882006753 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 886882006754 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 886882006755 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 886882006756 HTH domain; Region: HTH_11; pfam08279 886882006757 3H domain; Region: 3H; pfam02829 886882006758 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 886882006759 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 886882006760 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 886882006761 catalytic residue [active] 886882006762 quinolinate synthetase; Provisional; Region: PRK09375 886882006763 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 886882006764 PQQ-like domain; Region: PQQ_2; pfam13360 886882006765 active site 886882006766 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 886882006767 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882006768 Coenzyme A binding pocket [chemical binding]; other site 886882006769 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 886882006770 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 886882006771 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 886882006772 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 886882006773 active site 886882006774 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 886882006775 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 886882006776 active site 886882006777 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882006778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882006779 active site 886882006780 phosphorylation site [posttranslational modification] 886882006781 intermolecular recognition site; other site 886882006782 dimerization interface [polypeptide binding]; other site 886882006783 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882006784 DNA binding site [nucleotide binding] 886882006785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882006786 HAMP domain; Region: HAMP; pfam00672 886882006787 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882006788 dimer interface [polypeptide binding]; other site 886882006789 phosphorylation site [posttranslational modification] 886882006790 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882006791 ATP binding site [chemical binding]; other site 886882006792 Mg2+ binding site [ion binding]; other site 886882006793 G-X-G motif; other site 886882006794 NlpC/P60 family; Region: NLPC_P60; pfam00877 886882006795 This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802 886882006796 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 886882006797 putative ADP-binding pocket [chemical binding]; other site 886882006798 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 886882006799 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 886882006800 active site 886882006801 Zn binding site [ion binding]; other site 886882006802 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 886882006803 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 886882006804 active site 886882006805 Cupin domain; Region: Cupin_2; cl17218 886882006806 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 886882006807 Cupin; Region: Cupin_1; smart00835 886882006808 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 886882006809 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 886882006810 Walker A/P-loop; other site 886882006811 ATP binding site [chemical binding]; other site 886882006812 Q-loop/lid; other site 886882006813 ABC transporter signature motif; other site 886882006814 Walker B; other site 886882006815 D-loop; other site 886882006816 H-loop/switch region; other site 886882006817 Predicted permeases [General function prediction only]; Region: COG0679 886882006818 hypothetical protein; Validated; Region: PRK01415 886882006819 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 886882006820 active site residue [active] 886882006821 alpha-galactosidase; Region: PLN02808; cl17638 886882006822 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 886882006823 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 886882006824 substrate binding site [chemical binding]; other site 886882006825 ATP binding site [chemical binding]; other site 886882006826 topology modulation protein; Reviewed; Region: PRK08118 886882006827 AAA domain; Region: AAA_17; pfam13207 886882006828 prolyl-tRNA synthetase; Provisional; Region: PRK09194 886882006829 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 886882006830 dimer interface [polypeptide binding]; other site 886882006831 motif 1; other site 886882006832 active site 886882006833 motif 2; other site 886882006834 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 886882006835 putative deacylase active site [active] 886882006836 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 886882006837 active site 886882006838 motif 3; other site 886882006839 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 886882006840 anticodon binding site; other site 886882006841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 886882006842 hypothetical protein; Provisional; Region: PRK12378 886882006843 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882006844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882006845 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531 886882006846 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882006847 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 886882006848 NAD(P) binding site [chemical binding]; other site 886882006849 active site 886882006850 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 886882006851 Cupin; Region: Cupin_1; smart00835 886882006852 Cupin; Region: Cupin_1; smart00835 886882006853 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 886882006854 putative deacylase active site [active] 886882006855 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 886882006856 L11 interface [polypeptide binding]; other site 886882006857 putative EF-Tu interaction site [polypeptide binding]; other site 886882006858 putative EF-G interaction site [polypeptide binding]; other site 886882006859 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 886882006860 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 886882006861 nucleotide binding site [chemical binding]; other site 886882006862 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 886882006863 beta-galactosidase; Region: BGL; TIGR03356 886882006864 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 886882006865 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 886882006866 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 886882006867 active site 886882006868 metal binding site [ion binding]; metal-binding site 886882006869 homotetramer interface [polypeptide binding]; other site 886882006870 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 886882006871 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 886882006872 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 886882006873 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 886882006874 putative active site; other site 886882006875 catalytic triad [active] 886882006876 putative dimer interface [polypeptide binding]; other site 886882006877 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 886882006878 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 886882006879 active site 886882006880 FMN binding site [chemical binding]; other site 886882006881 substrate binding site [chemical binding]; other site 886882006882 putative catalytic residue [active] 886882006883 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 886882006884 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882006885 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882006886 Phosphotransferase enzyme family; Region: APH; pfam01636 886882006887 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 886882006888 active site 886882006889 substrate binding site [chemical binding]; other site 886882006890 ATP binding site [chemical binding]; other site 886882006891 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 886882006892 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 886882006893 intersubunit interface [polypeptide binding]; other site 886882006894 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 886882006895 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882006896 ABC-ATPase subunit interface; other site 886882006897 dimer interface [polypeptide binding]; other site 886882006898 putative PBP binding regions; other site 886882006899 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 886882006900 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882006901 ABC-ATPase subunit interface; other site 886882006902 dimer interface [polypeptide binding]; other site 886882006903 putative PBP binding regions; other site 886882006904 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882006905 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 886882006906 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 886882006907 dimer interface [polypeptide binding]; other site 886882006908 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 886882006909 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 886882006910 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 886882006911 RNA binding surface [nucleotide binding]; other site 886882006912 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 886882006913 probable active site [active] 886882006914 Spore germination protein; Region: Spore_permease; cl17796 886882006915 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 886882006916 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 886882006917 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 886882006918 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 886882006919 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 886882006920 TAP-like protein; Region: Abhydrolase_4; pfam08386 886882006921 Proteins of 100 residues with WXG; Region: WXG100; cl02005 886882006922 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882006923 MarR family; Region: MarR_2; pfam12802 886882006924 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 886882006925 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 886882006926 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 886882006927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 886882006928 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882006929 S-adenosylmethionine binding site [chemical binding]; other site 886882006930 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 886882006931 Archaeal putative transposase ISC1217; Region: DDE_Tnp_2; pfam04693 886882006932 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 886882006933 VanZ like family; Region: VanZ; pfam04892 886882006934 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 886882006935 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 886882006936 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 886882006937 active site 886882006938 catalytic residues [active] 886882006939 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 886882006940 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 886882006941 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 886882006942 oligomer interface [polypeptide binding]; other site 886882006943 active site residues [active] 886882006944 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 886882006945 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882006946 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882006947 DNA binding residues [nucleotide binding] 886882006948 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 886882006949 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 886882006950 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 886882006951 active site 886882006952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882006953 Mor transcription activator family; Region: Mor; cl02360 886882006954 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 886882006955 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 886882006956 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 886882006957 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 886882006958 catalytic residues [active] 886882006959 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 886882006960 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cl00144 886882006961 Cache domain; Region: Cache_1; pfam02743 886882006962 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882006963 dimerization interface [polypeptide binding]; other site 886882006964 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882006965 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882006966 dimer interface [polypeptide binding]; other site 886882006967 putative CheW interface [polypeptide binding]; other site 886882006968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882006969 dimer interface [polypeptide binding]; other site 886882006970 phosphorylation site [posttranslational modification] 886882006971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882006972 ATP binding site [chemical binding]; other site 886882006973 Mg2+ binding site [ion binding]; other site 886882006974 G-X-G motif; other site 886882006975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882006976 Response regulator receiver domain; Region: Response_reg; pfam00072 886882006977 active site 886882006978 phosphorylation site [posttranslational modification] 886882006979 intermolecular recognition site; other site 886882006980 dimerization interface [polypeptide binding]; other site 886882006981 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 886882006982 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882006983 active site 886882006984 phosphorylation site [posttranslational modification] 886882006985 intermolecular recognition site; other site 886882006986 dimerization interface [polypeptide binding]; other site 886882006987 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882006988 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882006989 active site 886882006990 phosphorylation site [posttranslational modification] 886882006991 intermolecular recognition site; other site 886882006992 dimerization interface [polypeptide binding]; other site 886882006993 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882006994 DNA binding site [nucleotide binding] 886882006995 diaminobutyrate--2-oxoglutarate aminotransferase; Validated; Region: PRK09264 886882006996 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 886882006997 inhibitor-cofactor binding pocket; inhibition site 886882006998 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882006999 catalytic residue [active] 886882007000 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 886882007001 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 886882007002 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 886882007003 metal binding site [ion binding]; metal-binding site 886882007004 active site 886882007005 I-site; other site 886882007006 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 886882007007 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 886882007008 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 886882007009 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 886882007010 Glycosyl hydrolase family 48; Region: Glyco_hydro_48; pfam02011 886882007011 Cellulose binding domain; Region: CBM_3; pfam00942 886882007012 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 886882007013 Ferritin-like domain; Region: Ferritin; pfam00210 886882007014 ferroxidase diiron center [ion binding]; other site 886882007015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882007016 Coenzyme A binding pocket [chemical binding]; other site 886882007017 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 886882007018 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 886882007019 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 886882007020 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 886882007021 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 886882007022 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 886882007023 acyl-activating enzyme (AAE) consensus motif; other site 886882007024 AMP binding site [chemical binding]; other site 886882007025 active site 886882007026 CoA binding site [chemical binding]; other site 886882007027 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 886882007028 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 886882007029 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882007030 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882007031 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 886882007032 Domain of unknown function (DUF4309); Region: DUF4309; pfam14172 886882007033 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882007034 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882007035 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 886882007036 CPxP motif; other site 886882007037 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 886882007038 active site residue [active] 886882007039 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 886882007040 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 886882007041 putative homodimer interface [polypeptide binding]; other site 886882007042 putative homotetramer interface [polypeptide binding]; other site 886882007043 putative metal binding site [ion binding]; other site 886882007044 putative homodimer-homodimer interface [polypeptide binding]; other site 886882007045 putative allosteric switch controlling residues; other site 886882007046 Predicted membrane protein [Function unknown]; Region: COG2323 886882007047 Spore germination protein; Region: Spore_permease; cl17796 886882007048 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 886882007049 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 886882007050 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 886882007051 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 886882007052 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 886882007053 homodimer interface [polypeptide binding]; other site 886882007054 substrate-cofactor binding pocket; other site 886882007055 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882007056 catalytic residue [active] 886882007057 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 886882007058 Calmodulin-binding; Region: Enkurin; pfam13864 886882007059 dUMP phosphatase; Provisional; Region: PRK09449 886882007060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882007061 motif II; other site 886882007062 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 886882007063 Melibiase; Region: Melibiase; pfam02065 886882007064 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882007065 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882007066 DNA binding site [nucleotide binding] 886882007067 domain linker motif; other site 886882007068 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 886882007069 putative dimerization interface [polypeptide binding]; other site 886882007070 putative ligand binding site [chemical binding]; other site 886882007071 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 886882007072 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882007073 dimerization interface [polypeptide binding]; other site 886882007074 Histidine kinase; Region: His_kinase; pfam06580 886882007075 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882007076 ATP binding site [chemical binding]; other site 886882007077 Mg2+ binding site [ion binding]; other site 886882007078 G-X-G motif; other site 886882007079 Response regulator receiver domain; Region: Response_reg; pfam00072 886882007080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882007081 active site 886882007082 phosphorylation site [posttranslational modification] 886882007083 intermolecular recognition site; other site 886882007084 dimerization interface [polypeptide binding]; other site 886882007085 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882007086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882007087 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882007088 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882007089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882007090 dimer interface [polypeptide binding]; other site 886882007091 conserved gate region; other site 886882007092 putative PBP binding loops; other site 886882007093 ABC-ATPase subunit interface; other site 886882007094 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882007095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882007096 dimer interface [polypeptide binding]; other site 886882007097 conserved gate region; other site 886882007098 putative PBP binding loops; other site 886882007099 ABC-ATPase subunit interface; other site 886882007100 trehalose synthase; Region: treS_nterm; TIGR02456 886882007101 Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac2_AmyA; cd11316 886882007102 Ca binding site [ion binding]; other site 886882007103 active site 886882007104 catalytic site [active] 886882007105 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 886882007106 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 886882007107 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882007108 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 886882007109 Protein of unknown function (DUF3231); Region: DUF3231; pfam11553 886882007110 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 886882007111 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 886882007112 active site 886882007113 FMN binding site [chemical binding]; other site 886882007114 substrate binding site [chemical binding]; other site 886882007115 homotetramer interface [polypeptide binding]; other site 886882007116 catalytic residue [active] 886882007117 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 886882007118 Helix-turn-helix domain; Region: HTH_18; pfam12833 886882007119 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882007120 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 886882007121 classical (c) SDRs; Region: SDR_c; cd05233 886882007122 NAD(P) binding site [chemical binding]; other site 886882007123 active site 886882007124 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882007125 putative substrate translocation pore; other site 886882007126 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882007127 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882007128 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882007129 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 886882007130 dimerization interface [polypeptide binding]; other site 886882007131 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882007132 putative substrate translocation pore; other site 886882007133 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882007134 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882007135 DNA binding site [nucleotide binding] 886882007136 domain linker motif; other site 886882007137 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 886882007138 dimerization interface [polypeptide binding]; other site 886882007139 ligand binding site [chemical binding]; other site 886882007140 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 886882007141 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 886882007142 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 886882007143 active site 886882007144 catalytic tetrad [active] 886882007145 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882007146 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882007147 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882007148 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882007149 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 886882007150 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 886882007151 phosphate binding site [ion binding]; other site 886882007152 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 886882007153 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882007154 DNA-binding site [nucleotide binding]; DNA binding site 886882007155 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882007156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882007157 homodimer interface [polypeptide binding]; other site 886882007158 catalytic residue [active] 886882007159 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 886882007160 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 886882007161 ATP-grasp domain; Region: ATP-grasp_4; cl17255 886882007162 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 886882007163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882007164 Coenzyme A binding pocket [chemical binding]; other site 886882007165 Protein of unknown function (DUF1349); Region: DUF1349; pfam07081 886882007166 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 886882007167 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 886882007168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882007169 motif II; other site 886882007170 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 886882007171 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 886882007172 NAD(P) binding site [chemical binding]; other site 886882007173 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 886882007174 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 886882007175 inhibitor-cofactor binding pocket; inhibition site 886882007176 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882007177 catalytic residue [active] 886882007178 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 886882007179 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 886882007180 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 886882007181 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 886882007182 mannonate dehydratase; Provisional; Region: PRK03906 886882007183 mannonate dehydratase; Region: uxuA; TIGR00695 886882007184 Transcriptional regulators [Transcription]; Region: GntR; COG1802 886882007185 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882007186 DNA-binding site [nucleotide binding]; DNA binding site 886882007187 FCD domain; Region: FCD; pfam07729 886882007188 D-mannonate oxidoreductase; Provisional; Region: PRK08277 886882007189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882007190 NAD(P) binding site [chemical binding]; other site 886882007191 active site 886882007192 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882007193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882007194 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882007195 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882007196 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 886882007197 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 886882007198 inhibitor site; inhibition site 886882007199 active site 886882007200 dimer interface [polypeptide binding]; other site 886882007201 catalytic residue [active] 886882007202 Predicted membrane protein [Function unknown]; Region: COG2364 886882007203 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 886882007204 Transcriptional regulators [Transcription]; Region: MarR; COG1846 886882007205 MarR family; Region: MarR_2; pfam12802 886882007206 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 886882007207 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882007208 Coenzyme A binding pocket [chemical binding]; other site 886882007209 amidase; Validated; Region: PRK06565 886882007210 Amidase; Region: Amidase; cl11426 886882007211 Amidase; Region: Amidase; cl11426 886882007212 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 886882007213 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 886882007214 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 886882007215 Ligand Binding Site [chemical binding]; other site 886882007216 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 886882007217 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882007218 dimer interface [polypeptide binding]; other site 886882007219 phosphorylation site [posttranslational modification] 886882007220 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882007221 ATP binding site [chemical binding]; other site 886882007222 Mg2+ binding site [ion binding]; other site 886882007223 G-X-G motif; other site 886882007224 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882007225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882007226 active site 886882007227 phosphorylation site [posttranslational modification] 886882007228 intermolecular recognition site; other site 886882007229 dimerization interface [polypeptide binding]; other site 886882007230 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882007231 DNA binding site [nucleotide binding] 886882007232 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 886882007233 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 886882007234 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 886882007235 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 886882007236 Alginate Lyase A1-III; enzymatically depolymerizes alginate, a complex copolymer of beta-D-mannuronate and alpha-L-guluronate, by cleaving the beta-(1,4) glycosidic bond; Region: AlgLyase; cl00179 886882007237 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 886882007238 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 886882007239 putative sugar binding sites [chemical binding]; other site 886882007240 Q-X-W motif; other site 886882007241 Nitronate monooxygenase; Region: NMO; pfam03060 886882007242 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 886882007243 FMN binding site [chemical binding]; other site 886882007244 substrate binding site [chemical binding]; other site 886882007245 putative catalytic residue [active] 886882007246 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 886882007247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882007248 Walker A motif; other site 886882007249 ATP binding site [chemical binding]; other site 886882007250 Walker B motif; other site 886882007251 arginine finger; other site 886882007252 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 886882007253 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 886882007254 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 886882007255 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 886882007256 P-loop, Walker A motif; other site 886882007257 Base recognition motif; other site 886882007258 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 886882007259 Transcriptional regulators [Transcription]; Region: MarR; COG1846 886882007260 MarR family; Region: MarR_2; pfam12802 886882007261 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882007262 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882007263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882007264 Walker A/P-loop; other site 886882007265 ATP binding site [chemical binding]; other site 886882007266 Q-loop/lid; other site 886882007267 ABC transporter signature motif; other site 886882007268 Walker B; other site 886882007269 D-loop; other site 886882007270 H-loop/switch region; other site 886882007271 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882007272 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882007273 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 886882007274 Walker A/P-loop; other site 886882007275 ATP binding site [chemical binding]; other site 886882007276 Q-loop/lid; other site 886882007277 ABC transporter signature motif; other site 886882007278 Walker B; other site 886882007279 D-loop; other site 886882007280 H-loop/switch region; other site 886882007281 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 886882007282 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 886882007283 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 886882007284 NAD(P) binding site [chemical binding]; other site 886882007285 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 886882007286 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 886882007287 catalytic residues [active] 886882007288 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 886882007289 classical (c) SDRs; Region: SDR_c; cd05233 886882007290 NAD(P) binding site [chemical binding]; other site 886882007291 active site 886882007292 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 886882007293 Monoamine oxidase [Amino acid transport and metabolism]; Region: COG1231 886882007294 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 886882007295 catalytic residues [active] 886882007296 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882007297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882007298 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882007299 dimerization interface [polypeptide binding]; other site 886882007300 putative DNA binding site [nucleotide binding]; other site 886882007301 putative Zn2+ binding site [ion binding]; other site 886882007302 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 886882007303 active site residue [active] 886882007304 OsmC-like protein; Region: OsmC; cl00767 886882007305 RNA polymerase sigma-70 factor, TIGR02954 family; Region: Sig70_famx3 886882007306 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882007307 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882007308 DNA binding residues [nucleotide binding] 886882007309 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 886882007310 Condensation domain; Region: Condensation; pfam00668 886882007311 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007312 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882007313 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882007314 acyl-activating enzyme (AAE) consensus motif; other site 886882007315 AMP binding site [chemical binding]; other site 886882007316 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007317 Condensation domain; Region: Condensation; pfam00668 886882007318 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007319 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882007320 Condensation domain; Region: Condensation; pfam00668 886882007321 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007322 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 886882007323 acyl-activating enzyme (AAE) consensus motif; other site 886882007324 AMP binding site [chemical binding]; other site 886882007325 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007326 Condensation domain; Region: Condensation; pfam00668 886882007327 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007328 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882007329 Condensation domain; Region: Condensation; pfam00668 886882007330 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007331 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882007332 acyl-activating enzyme (AAE) consensus motif; other site 886882007333 AMP binding site [chemical binding]; other site 886882007334 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007335 Condensation domain; Region: Condensation; pfam00668 886882007336 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007337 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882007338 Condensation domain; Region: Condensation; pfam00668 886882007339 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007340 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882007341 acyl-activating enzyme (AAE) consensus motif; other site 886882007342 AMP binding site [chemical binding]; other site 886882007343 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007344 Condensation domain; Region: Condensation; pfam00668 886882007345 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007346 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882007347 Condensation domain; Region: Condensation; pfam00668 886882007348 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007349 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882007350 acyl-activating enzyme (AAE) consensus motif; other site 886882007351 AMP binding site [chemical binding]; other site 886882007352 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007353 Condensation domain; Region: Condensation; pfam00668 886882007354 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007355 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882007356 Condensation domain; Region: Condensation; pfam00668 886882007357 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007358 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882007359 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882007360 acyl-activating enzyme (AAE) consensus motif; other site 886882007361 AMP binding site [chemical binding]; other site 886882007362 peptide synthase; Validated; Region: PRK05691 886882007363 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007364 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882007365 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 886882007366 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882007367 acyl-activating enzyme (AAE) consensus motif; other site 886882007368 AMP binding site [chemical binding]; other site 886882007369 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007370 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882007371 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 886882007372 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882007373 acyl-activating enzyme (AAE) consensus motif; other site 886882007374 AMP binding site [chemical binding]; other site 886882007375 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007376 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882007377 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 886882007378 acyl-activating enzyme (AAE) consensus motif; other site 886882007379 AMP binding site [chemical binding]; other site 886882007380 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007381 Condensation domain; Region: Condensation; pfam00668 886882007382 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007383 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882007384 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882007385 acyl-activating enzyme (AAE) consensus motif; other site 886882007386 AMP binding site [chemical binding]; other site 886882007387 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007388 Condensation domain; Region: Condensation; pfam00668 886882007389 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007390 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882007391 Glycosyl hydrolase family 43; Region: GH43_AXH_1; cd09003 886882007392 substrate binding site [chemical binding]; other site 886882007393 active site 886882007394 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 886882007395 metal binding site [ion binding]; metal-binding site 886882007396 ligand binding site [chemical binding]; other site 886882007397 Carbohydrate Binding Module families 36 (CBM36) and 6 (CBM6); appended mainly to glycoside hydrolase family 11 (GH11) domains; xylan binding; Region: CBM6_36_xylanase-like; cd04078 886882007398 Ca binding site [ion binding]; other site 886882007399 Ca binding site (active) [ion binding]; other site 886882007400 ligand binding site [chemical binding]; other site 886882007401 lichenase, member of glycosyl hydrolase family 16; Region: GH16_lichenase; cd02175 886882007402 Beta-glucanase/Beta-glucan synthetase [Carbohydrate transport and metabolism]; Region: SKN1; COG2273 886882007403 active site 886882007404 active site 886882007405 catalytic residues [active] 886882007406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882007407 Coenzyme A binding pocket [chemical binding]; other site 886882007408 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 886882007409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882007410 active site 886882007411 phosphorylation site [posttranslational modification] 886882007412 intermolecular recognition site; other site 886882007413 dimerization interface [polypeptide binding]; other site 886882007414 LytTr DNA-binding domain; Region: LytTR; pfam04397 886882007415 Oligosaccharyl transferase STT3 subunit; Region: STT3; pfam02516 886882007416 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 886882007417 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 886882007418 Beta-lactamase; Region: Beta-lactamase; pfam00144 886882007419 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882007420 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882007421 DNA binding site [nucleotide binding] 886882007422 domain linker motif; other site 886882007423 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 886882007424 dimerization interface [polypeptide binding]; other site 886882007425 ligand binding site [chemical binding]; other site 886882007426 sodium binding site [ion binding]; other site 886882007427 galactoside permease; Reviewed; Region: lacY; PRK09528 886882007428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882007429 putative substrate translocation pore; other site 886882007430 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 886882007431 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 886882007432 substrate binding [chemical binding]; other site 886882007433 active site 886882007434 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 886882007435 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882007436 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882007437 DNA binding site [nucleotide binding] 886882007438 domain linker motif; other site 886882007439 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 886882007440 dimerization interface [polypeptide binding]; other site 886882007441 ligand binding site [chemical binding]; other site 886882007442 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 886882007443 MFS/sugar transport protein; Region: MFS_2; pfam13347 886882007444 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 886882007445 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 886882007446 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 886882007447 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 886882007448 acyl-activating enzyme (AAE) consensus motif; other site 886882007449 putative AMP binding site [chemical binding]; other site 886882007450 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007451 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08722 886882007452 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 886882007453 active site 886882007454 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007455 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 886882007456 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 886882007457 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 886882007458 catalytic residue [active] 886882007459 Condensation domain; Region: Condensation; pfam00668 886882007460 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007461 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882007462 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 886882007463 CoA binding site [chemical binding]; other site 886882007464 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007465 Condensation domain; Region: Condensation; pfam00668 886882007466 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007467 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882007468 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882007469 acyl-activating enzyme (AAE) consensus motif; other site 886882007470 AMP binding site [chemical binding]; other site 886882007471 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007472 Condensation domain; Region: Condensation; pfam00668 886882007473 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882007474 Condensation domain; Region: Condensation; pfam00668 886882007475 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007476 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882007477 acyl-activating enzyme (AAE) consensus motif; other site 886882007478 AMP binding site [chemical binding]; other site 886882007479 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007480 Condensation domain; Region: Condensation; pfam00668 886882007481 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882007482 Condensation domain; Region: Condensation; pfam00668 886882007483 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007484 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 886882007485 acyl-activating enzyme (AAE) consensus motif; other site 886882007486 AMP binding site [chemical binding]; other site 886882007487 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007488 Condensation domain; Region: Condensation; pfam00668 886882007489 muropeptide transporter; Validated; Region: ampG; cl17669 886882007490 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882007491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882007492 active site 886882007493 phosphorylation site [posttranslational modification] 886882007494 intermolecular recognition site; other site 886882007495 dimerization interface [polypeptide binding]; other site 886882007496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882007497 DNA binding site [nucleotide binding] 886882007498 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882007499 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882007500 dimerization interface [polypeptide binding]; other site 886882007501 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882007502 dimer interface [polypeptide binding]; other site 886882007503 phosphorylation site [posttranslational modification] 886882007504 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882007505 ATP binding site [chemical binding]; other site 886882007506 Mg2+ binding site [ion binding]; other site 886882007507 G-X-G motif; other site 886882007508 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 886882007509 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 886882007510 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882007511 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882007512 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882007513 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882007514 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 886882007515 putative dimerization interface [polypeptide binding]; other site 886882007516 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 886882007517 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 886882007518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882007519 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882007520 putative substrate translocation pore; other site 886882007521 glutamate racemase; Provisional; Region: PRK00865 886882007522 Tautomerase enzyme; Region: Tautomerase; pfam01361 886882007523 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 886882007524 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 886882007525 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 886882007526 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 886882007527 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882007528 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 886882007529 active site 886882007530 motif I; other site 886882007531 motif II; other site 886882007532 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 886882007533 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 886882007534 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 886882007535 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882007536 N-acetylneuraminate lyase; Region: nanA; TIGR00683 886882007537 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 886882007538 inhibitor site; inhibition site 886882007539 active site 886882007540 dimer interface [polypeptide binding]; other site 886882007541 catalytic residue [active] 886882007542 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882007543 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882007544 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882007545 dimerization interface [polypeptide binding]; other site 886882007546 Major royal jelly protein; Region: MRJP; pfam03022 886882007547 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 886882007548 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 886882007549 NAD(P) binding site [chemical binding]; other site 886882007550 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 886882007551 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 886882007552 Spore germination protein; Region: Spore_permease; cl17796 886882007553 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 886882007554 ASC-1 homology domain, ASC-1-like subfamily. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain...; Region: ASCH_ASC-1_like; cd06554 886882007555 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882007556 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 886882007557 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 886882007558 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 886882007559 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 886882007560 acetoacetate decarboxylase; Provisional; Region: PRK02265 886882007561 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882007562 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882007563 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882007564 dimerization interface [polypeptide binding]; other site 886882007565 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 886882007566 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 886882007567 Beta-lactamase; Region: Beta-lactamase; pfam00144 886882007568 Erythromycin esterase; Region: Erythro_esteras; pfam05139 886882007569 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 886882007570 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 886882007571 S-layer homology domain; Region: SLH; pfam00395 886882007572 S-layer homology domain; Region: SLH; pfam00395 886882007573 Protein of unknown function (DUF421); Region: DUF421; pfam04239 886882007574 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 886882007575 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 886882007576 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 886882007577 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882007578 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882007579 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 886882007580 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882007581 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882007582 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882007583 beta-D-glucuronidase; Provisional; Region: PRK10150 886882007584 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 886882007585 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 886882007586 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 886882007587 Transcriptional regulators [Transcription]; Region: MarR; COG1846 886882007588 MarR family; Region: MarR_2; pfam12802 886882007589 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 886882007590 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882007591 Coenzyme A binding pocket [chemical binding]; other site 886882007592 LamG-like jellyroll fold domain; Region: LamGL; smart00560 886882007593 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 886882007594 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 886882007595 substrate binding [chemical binding]; other site 886882007596 active site 886882007597 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 886882007598 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 886882007599 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 886882007600 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 886882007601 substrate binding [chemical binding]; other site 886882007602 active site 886882007603 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 886882007604 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 886882007605 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 886882007606 putative substrate binding site [chemical binding]; other site 886882007607 putative ATP binding site [chemical binding]; other site 886882007608 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 886882007609 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 886882007610 substrate binding [chemical binding]; other site 886882007611 active site 886882007612 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 886882007613 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882007614 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882007615 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882007616 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882007617 dimer interface [polypeptide binding]; other site 886882007618 conserved gate region; other site 886882007619 putative PBP binding loops; other site 886882007620 ABC-ATPase subunit interface; other site 886882007621 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882007622 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882007623 dimer interface [polypeptide binding]; other site 886882007624 conserved gate region; other site 886882007625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 886882007626 ABC-ATPase subunit interface; other site 886882007627 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882007628 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882007629 DNA binding site [nucleotide binding] 886882007630 domain linker motif; other site 886882007631 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 886882007632 dimerization interface [polypeptide binding]; other site 886882007633 ligand binding site [chemical binding]; other site 886882007634 sodium binding site [ion binding]; other site 886882007635 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 886882007636 Penicillinase repressor; Region: Pencillinase_R; cl17580 886882007637 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 886882007638 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 886882007639 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882007640 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882007641 putative substrate translocation pore; other site 886882007642 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 886882007643 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 886882007644 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 886882007645 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 886882007646 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 886882007647 NodB motif; other site 886882007648 putative active site [active] 886882007649 putative catalytic site [active] 886882007650 putative Zn binding site [ion binding]; other site 886882007651 diacylglycerol glucosyltransferase; Provisional; Region: PRK13609 886882007652 Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925 886882007653 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 886882007654 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 886882007655 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 886882007656 active site 886882007657 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 886882007658 Predicted membrane protein [Function unknown]; Region: COG1238 886882007659 phosphoenolpyruvate synthase; Validated; Region: PRK06241 886882007660 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 886882007661 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 886882007662 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882007663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882007664 conserved gate region; other site 886882007665 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 886882007666 ABC-ATPase subunit interface; other site 886882007667 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882007668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882007669 dimer interface [polypeptide binding]; other site 886882007670 conserved gate region; other site 886882007671 ABC-ATPase subunit interface; other site 886882007672 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882007673 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 886882007674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882007675 active site 886882007676 phosphorylation site [posttranslational modification] 886882007677 intermolecular recognition site; other site 886882007678 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882007679 Histidine kinase; Region: His_kinase; pfam06580 886882007680 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882007681 ATP binding site [chemical binding]; other site 886882007682 Mg2+ binding site [ion binding]; other site 886882007683 G-X-G motif; other site 886882007684 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 886882007685 Right handed beta helix region; Region: Beta_helix; pfam13229 886882007686 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 886882007687 dimer interface [polypeptide binding]; other site 886882007688 FMN binding site [chemical binding]; other site 886882007689 Rrf2 family protein; Region: rrf2_super; TIGR00738 886882007690 Transcriptional regulator; Region: Rrf2; pfam02082 886882007691 Transcriptional regulator; Region: Rrf2; cl17282 886882007692 glycosyltransferase, MGT family; Region: MGT; TIGR01426 886882007693 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 886882007694 sugar binding site [chemical binding]; other site 886882007695 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882007696 Interdomain contacts; other site 886882007697 Cytokine receptor motif; other site 886882007698 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 886882007699 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 886882007700 putative sugar binding sites [chemical binding]; other site 886882007701 Q-X-W motif; other site 886882007702 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882007703 Interdomain contacts; other site 886882007704 Cytokine receptor motif; other site 886882007705 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 886882007706 Domain of unknown function (DUF4272); Region: DUF4272; pfam14094 886882007707 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 886882007708 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882007709 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 886882007710 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 886882007711 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882007712 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 886882007713 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882007714 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882007715 DNA binding site [nucleotide binding] 886882007716 domain linker motif; other site 886882007717 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 886882007718 ligand binding site [chemical binding]; other site 886882007719 dimerization interface [polypeptide binding]; other site 886882007720 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 886882007721 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 886882007722 Melibiase; Region: Melibiase; pfam02065 886882007723 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 886882007724 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882007725 putative oxidoreductase; Provisional; Region: PRK10206 886882007726 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882007727 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 886882007728 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 886882007729 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 886882007730 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 886882007731 putative active site [active] 886882007732 helix_turn_helix, Arsenical Resistance Operon Repressor; Region: HTH_ARSR; smart00418 886882007733 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 886882007734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882007735 putative substrate translocation pore; other site 886882007736 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 886882007737 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 886882007738 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 886882007739 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 886882007740 Walker A/P-loop; other site 886882007741 ATP binding site [chemical binding]; other site 886882007742 Q-loop/lid; other site 886882007743 ABC transporter signature motif; other site 886882007744 Walker B; other site 886882007745 D-loop; other site 886882007746 H-loop/switch region; other site 886882007747 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 886882007748 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 886882007749 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 886882007750 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882007751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882007752 active site 886882007753 phosphorylation site [posttranslational modification] 886882007754 intermolecular recognition site; other site 886882007755 dimerization interface [polypeptide binding]; other site 886882007756 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882007757 DNA binding site [nucleotide binding] 886882007758 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882007759 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882007760 dimer interface [polypeptide binding]; other site 886882007761 phosphorylation site [posttranslational modification] 886882007762 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882007763 ATP binding site [chemical binding]; other site 886882007764 Mg2+ binding site [ion binding]; other site 886882007765 G-X-G motif; other site 886882007766 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882007767 Interdomain contacts; other site 886882007768 Cytokine receptor motif; other site 886882007769 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882007770 integral membrane protein; Region: integ_memb_HG; TIGR03954 886882007771 YolD-like protein; Region: YolD; pfam08863 886882007772 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882007773 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882007774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882007775 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 886882007776 putative substrate translocation pore; other site 886882007777 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 886882007778 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 886882007779 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 886882007780 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882007781 dimer interface [polypeptide binding]; other site 886882007782 conserved gate region; other site 886882007783 putative PBP binding loops; other site 886882007784 ABC-ATPase subunit interface; other site 886882007785 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 886882007786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882007787 dimer interface [polypeptide binding]; other site 886882007788 conserved gate region; other site 886882007789 putative PBP binding loops; other site 886882007790 ABC-ATPase subunit interface; other site 886882007791 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 886882007792 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 886882007793 Walker A/P-loop; other site 886882007794 ATP binding site [chemical binding]; other site 886882007795 Q-loop/lid; other site 886882007796 ABC transporter signature motif; other site 886882007797 Walker B; other site 886882007798 D-loop; other site 886882007799 H-loop/switch region; other site 886882007800 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 886882007801 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 886882007802 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 886882007803 Walker A/P-loop; other site 886882007804 ATP binding site [chemical binding]; other site 886882007805 Q-loop/lid; other site 886882007806 ABC transporter signature motif; other site 886882007807 Walker B; other site 886882007808 D-loop; other site 886882007809 H-loop/switch region; other site 886882007810 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 886882007811 putative efflux protein, MATE family; Region: matE; TIGR00797 886882007812 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 886882007813 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 886882007814 tetramer interface [polypeptide binding]; other site 886882007815 heme binding pocket [chemical binding]; other site 886882007816 NADPH binding site [chemical binding]; other site 886882007817 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 886882007818 AAA domain; Region: AAA_33; pfam13671 886882007819 ligand-binding site [chemical binding]; other site 886882007820 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4295 886882007821 Uncharacterized protein conserved in bacteria (DUF2263); Region: DUF2263; pfam10021 886882007822 Domain of unknown function (DUF1768); Region: DUF1768; pfam08719 886882007823 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 886882007824 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 886882007825 nudix motif; other site 886882007826 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882007827 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 886882007828 acyl-activating enzyme (AAE) consensus motif; other site 886882007829 AMP binding site [chemical binding]; other site 886882007830 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007831 Condensation domain; Region: Condensation; pfam00668 886882007832 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007833 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882007834 Condensation domain; Region: Condensation; pfam00668 886882007835 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 886882007836 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 886882007837 acyl-activating enzyme (AAE) consensus motif; other site 886882007838 AMP binding site [chemical binding]; other site 886882007839 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007840 Condensation domain; Region: Condensation; pfam00668 886882007841 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882007842 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882007843 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 886882007844 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 886882007845 acyl-activating enzyme (AAE) consensus motif; other site 886882007846 AMP binding site [chemical binding]; other site 886882007847 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882007848 Condensation domain; Region: Condensation; pfam00668 886882007849 glutaminase A; Region: Gln_ase; TIGR03814 886882007850 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 886882007851 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 886882007852 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 886882007853 putative metal binding site [ion binding]; other site 886882007854 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 886882007855 active site 886882007856 Predicted membrane protein [Function unknown]; Region: COG2259 886882007857 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 886882007858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882007859 non-specific DNA binding site [nucleotide binding]; other site 886882007860 salt bridge; other site 886882007861 sequence-specific DNA binding site [nucleotide binding]; other site 886882007862 Cupin domain; Region: Cupin_2; pfam07883 886882007863 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882007864 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 886882007865 potassium/proton antiporter; Reviewed; Region: PRK05326 886882007866 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 886882007867 TrkA-C domain; Region: TrkA_C; pfam02080 886882007868 fumarate hydratase; Reviewed; Region: fumC; PRK00485 886882007869 Class II fumarases; Region: Fumarase_classII; cd01362 886882007870 active site 886882007871 tetramer interface [polypeptide binding]; other site 886882007872 2-isopropylmalate synthase; Validated; Region: PRK00915 886882007873 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 886882007874 active site 886882007875 catalytic residues [active] 886882007876 metal binding site [ion binding]; metal-binding site 886882007877 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 886882007878 Transcriptional regulators [Transcription]; Region: FadR; COG2186 886882007879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882007880 DNA-binding site [nucleotide binding]; DNA binding site 886882007881 FCD domain; Region: FCD; pfam07729 886882007882 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 886882007883 active site 886882007884 catalytic residues [active] 886882007885 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 886882007886 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 886882007887 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 886882007888 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 886882007889 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 886882007890 dimer interface [polypeptide binding]; other site 886882007891 active site 886882007892 metal binding site [ion binding]; metal-binding site 886882007893 biotin synthase; Validated; Region: PRK06256 886882007894 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882007895 FeS/SAM binding site; other site 886882007896 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 886882007897 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 886882007898 Domain of unknown function DUF21; Region: DUF21; pfam01595 886882007899 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 886882007900 Transporter associated domain; Region: CorC_HlyC; smart01091 886882007901 Spore coat protein (Spore_GerQ); Region: Spore_GerQ; pfam09671 886882007902 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 886882007903 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 886882007904 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882007905 NAD(P) binding site [chemical binding]; other site 886882007906 active site 886882007907 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 886882007908 Ycf48-like protein; Provisional; Region: PRK13684 886882007909 Ycf48-like protein; Provisional; Region: PRK13684 886882007910 amino acid transporter; Region: 2A0306; TIGR00909 886882007911 Spore germination protein; Region: Spore_permease; cl17796 886882007912 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 886882007913 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 886882007914 NAD binding site [chemical binding]; other site 886882007915 dimer interface [polypeptide binding]; other site 886882007916 substrate binding site [chemical binding]; other site 886882007917 tetramer (dimer of dimers) interface [polypeptide binding]; other site 886882007918 Protein of unknown function (DUF3900); Region: DUF3900; pfam13039 886882007919 Domain of unknown function (DUF3898); Region: DUF3898; pfam13037 886882007920 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882007921 H+ Antiporter protein; Region: 2A0121; TIGR00900 886882007922 putative substrate translocation pore; other site 886882007923 MutS domain III; Region: MutS_III; pfam05192 886882007924 DNA-binding domain of DNA mismatch repair MUTS family; Region: MUTSd; smart00533 886882007925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882007926 Walker A/P-loop; other site 886882007927 ATP binding site [chemical binding]; other site 886882007928 Q-loop/lid; other site 886882007929 ABC transporter signature motif; other site 886882007930 Walker B; other site 886882007931 D-loop; other site 886882007932 H-loop/switch region; other site 886882007933 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 886882007934 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 886882007935 nucleotide binding site [chemical binding]; other site 886882007936 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 886882007937 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882007938 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 886882007939 active site 886882007940 motif I; other site 886882007941 motif II; other site 886882007942 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 886882007943 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 886882007944 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 886882007945 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 886882007946 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 886882007947 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 886882007948 active site 886882007949 DNA binding site [nucleotide binding] 886882007950 Int/Topo IB signature motif; other site 886882007951 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 886882007952 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 886882007953 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882007954 ABC-ATPase subunit interface; other site 886882007955 dimer interface [polypeptide binding]; other site 886882007956 putative PBP binding regions; other site 886882007957 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 886882007958 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882007959 ABC-ATPase subunit interface; other site 886882007960 dimer interface [polypeptide binding]; other site 886882007961 putative PBP binding regions; other site 886882007962 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882007963 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882007964 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 886882007965 Walker A/P-loop; other site 886882007966 ATP binding site [chemical binding]; other site 886882007967 Q-loop/lid; other site 886882007968 ABC transporter signature motif; other site 886882007969 Walker B; other site 886882007970 D-loop; other site 886882007971 H-loop/switch region; other site 886882007972 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 886882007973 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 886882007974 intersubunit interface [polypeptide binding]; other site 886882007975 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 886882007976 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 886882007977 ligand binding site [chemical binding]; other site 886882007978 dimerization interface [polypeptide binding]; other site 886882007979 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 886882007980 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 886882007981 TM-ABC transporter signature motif; other site 886882007982 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 886882007983 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 886882007984 Walker A/P-loop; other site 886882007985 ATP binding site [chemical binding]; other site 886882007986 Q-loop/lid; other site 886882007987 ABC transporter signature motif; other site 886882007988 Walker B; other site 886882007989 D-loop; other site 886882007990 H-loop/switch region; other site 886882007991 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 886882007992 D-ribose pyranase; Provisional; Region: PRK11797 886882007993 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 886882007994 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 886882007995 substrate binding site [chemical binding]; other site 886882007996 dimer interface [polypeptide binding]; other site 886882007997 ATP binding site [chemical binding]; other site 886882007998 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882007999 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882008000 DNA binding site [nucleotide binding] 886882008001 domain linker motif; other site 886882008002 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 886882008003 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 886882008004 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 886882008005 catalytic residues [active] 886882008006 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 886882008007 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 886882008008 putative NAD(P) binding site [chemical binding]; other site 886882008009 putative active site [active] 886882008010 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882008011 Predicted permeases [General function prediction only]; Region: COG0679 886882008012 BNR repeat-like domain; Region: BNR_2; pfam13088 886882008013 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 886882008014 Cellulose binding domain; Region: CBM_3; pfam00942 886882008015 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 886882008016 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 886882008017 metal binding site [ion binding]; metal-binding site 886882008018 dimer interface [polypeptide binding]; other site 886882008019 Predicted acetyltransferase [General function prediction only]; Region: COG5628 886882008020 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 886882008021 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 886882008022 active site 886882008023 DNA binding site [nucleotide binding] 886882008024 Int/Topo IB signature motif; other site 886882008025 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 886882008026 Walker A motif; other site 886882008027 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 886882008028 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 886882008029 dimer interface [polypeptide binding]; other site 886882008030 putative functional site; other site 886882008031 putative MPT binding site; other site 886882008032 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882008033 non-specific DNA binding site [nucleotide binding]; other site 886882008034 salt bridge; other site 886882008035 sequence-specific DNA binding site [nucleotide binding]; other site 886882008036 Domain of unknown function (DUF4247); Region: DUF4247; pfam14042 886882008037 Domain of unknown function (DUF4178); Region: DUF4178; pfam13785 886882008038 Predicted membrane protein [Function unknown]; Region: COG3766 886882008039 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 886882008040 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 886882008041 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 886882008042 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 886882008043 active site 886882008044 FMN binding site [chemical binding]; other site 886882008045 substrate binding site [chemical binding]; other site 886882008046 homotetramer interface [polypeptide binding]; other site 886882008047 catalytic residue [active] 886882008048 delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884 886882008049 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 886882008050 NodB motif; other site 886882008051 active site 886882008052 catalytic site [active] 886882008053 metal binding site [ion binding]; metal-binding site 886882008054 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 886882008055 3D domain; Region: 3D; cl01439 886882008056 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 886882008057 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 886882008058 Walker A/P-loop; other site 886882008059 ATP binding site [chemical binding]; other site 886882008060 Q-loop/lid; other site 886882008061 ABC transporter signature motif; other site 886882008062 Walker B; other site 886882008063 D-loop; other site 886882008064 H-loop/switch region; other site 886882008065 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 886882008066 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 886882008067 substrate binding pocket [chemical binding]; other site 886882008068 membrane-bound complex binding site; other site 886882008069 hinge residues; other site 886882008070 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 886882008071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882008072 dimer interface [polypeptide binding]; other site 886882008073 conserved gate region; other site 886882008074 putative PBP binding loops; other site 886882008075 ABC-ATPase subunit interface; other site 886882008076 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 886882008077 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 886882008078 metal binding site [ion binding]; metal-binding site 886882008079 Uncharacterized conserved protein [Function unknown]; Region: COG4278 886882008080 glycogen synthase; Provisional; Region: glgA; PRK00654 886882008081 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 886882008082 ADP-binding pocket [chemical binding]; other site 886882008083 homodimer interface [polypeptide binding]; other site 886882008084 glycogen branching enzyme; Provisional; Region: PRK12313 886882008085 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 886882008086 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 886882008087 active site 886882008088 catalytic site [active] 886882008089 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 886882008090 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 886882008091 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 886882008092 ligand binding site; other site 886882008093 oligomer interface; other site 886882008094 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 886882008095 dimer interface [polypeptide binding]; other site 886882008096 N-terminal domain interface [polypeptide binding]; other site 886882008097 sulfate 1 binding site; other site 886882008098 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882008099 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882008100 dimerization interface [polypeptide binding]; other site 886882008101 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882008102 dimer interface [polypeptide binding]; other site 886882008103 phosphorylation site [posttranslational modification] 886882008104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882008105 ATP binding site [chemical binding]; other site 886882008106 Mg2+ binding site [ion binding]; other site 886882008107 G-X-G motif; other site 886882008108 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882008109 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882008110 active site 886882008111 phosphorylation site [posttranslational modification] 886882008112 intermolecular recognition site; other site 886882008113 dimerization interface [polypeptide binding]; other site 886882008114 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882008115 DNA binding site [nucleotide binding] 886882008116 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 886882008117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882008118 Walker A/P-loop; other site 886882008119 ATP binding site [chemical binding]; other site 886882008120 Q-loop/lid; other site 886882008121 ABC transporter signature motif; other site 886882008122 Walker B; other site 886882008123 D-loop; other site 886882008124 H-loop/switch region; other site 886882008125 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882008126 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882008127 putative substrate translocation pore; other site 886882008128 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 886882008129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882008130 motif II; other site 886882008131 DNA topoisomerase III; Provisional; Region: PRK07726 886882008132 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 886882008133 active site 886882008134 putative interdomain interaction site [polypeptide binding]; other site 886882008135 putative metal-binding site [ion binding]; other site 886882008136 putative nucleotide binding site [chemical binding]; other site 886882008137 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 886882008138 domain I; other site 886882008139 DNA binding groove [nucleotide binding] 886882008140 phosphate binding site [ion binding]; other site 886882008141 domain II; other site 886882008142 domain III; other site 886882008143 nucleotide binding site [chemical binding]; other site 886882008144 catalytic site [active] 886882008145 domain IV; other site 886882008146 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 886882008147 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 886882008148 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882008149 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 886882008150 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 886882008151 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 886882008152 folate binding site [chemical binding]; other site 886882008153 NADP+ binding site [chemical binding]; other site 886882008154 thymidylate synthase; Reviewed; Region: thyA; PRK01827 886882008155 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 886882008156 dimerization interface [polypeptide binding]; other site 886882008157 active site 886882008158 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 886882008159 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 886882008160 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882008161 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 886882008162 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 886882008163 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 886882008164 E3 interaction surface; other site 886882008165 lipoyl attachment site [posttranslational modification]; other site 886882008166 e3 binding domain; Region: E3_binding; pfam02817 886882008167 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 886882008168 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 886882008169 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 886882008170 alpha subunit interface [polypeptide binding]; other site 886882008171 TPP binding site [chemical binding]; other site 886882008172 heterodimer interface [polypeptide binding]; other site 886882008173 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 886882008174 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 886882008175 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 886882008176 TPP-binding site [chemical binding]; other site 886882008177 heterodimer interface [polypeptide binding]; other site 886882008178 tetramer interface [polypeptide binding]; other site 886882008179 phosphorylation loop region [posttranslational modification] 886882008180 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 886882008181 Putative esterase; Region: Esterase; pfam00756 886882008182 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 886882008183 Low molecular weight phosphatase family; Region: LMWPc; cd00115 886882008184 active site 886882008185 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 886882008186 Thiamine pyrophosphokinase; Region: TPK; cd07995 886882008187 active site 886882008188 dimerization interface [polypeptide binding]; other site 886882008189 thiamine binding site [chemical binding]; other site 886882008190 NlpC/P60 family; Region: NLPC_P60; pfam00877 886882008191 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882008192 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882008193 active site 886882008194 phosphorylation site [posttranslational modification] 886882008195 intermolecular recognition site; other site 886882008196 dimerization interface [polypeptide binding]; other site 886882008197 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882008198 DNA binding site [nucleotide binding] 886882008199 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 886882008200 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 886882008201 ATP binding site [chemical binding]; other site 886882008202 substrate interface [chemical binding]; other site 886882008203 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 886882008204 ThiS interaction site; other site 886882008205 putative active site [active] 886882008206 tetramer interface [polypeptide binding]; other site 886882008207 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 886882008208 thiS-thiF/thiG interaction site; other site 886882008209 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 886882008210 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 886882008211 active site 886882008212 thiamine phosphate binding site [chemical binding]; other site 886882008213 pyrophosphate binding site [ion binding]; other site 886882008214 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 886882008215 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882008216 Walker A/P-loop; other site 886882008217 ATP binding site [chemical binding]; other site 886882008218 Q-loop/lid; other site 886882008219 ABC transporter signature motif; other site 886882008220 Walker B; other site 886882008221 D-loop; other site 886882008222 H-loop/switch region; other site 886882008223 ABC transporter; Region: ABC_tran_2; pfam12848 886882008224 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 886882008225 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 886882008226 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 886882008227 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 886882008228 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 886882008229 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 886882008230 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 886882008231 Catalytic domain of Protein Kinases; Region: PKc; cd00180 886882008232 active site 886882008233 ATP binding site [chemical binding]; other site 886882008234 substrate binding site [chemical binding]; other site 886882008235 activation loop (A-loop); other site 886882008236 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2933 886882008237 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882008238 S-adenosylmethionine binding site [chemical binding]; other site 886882008239 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 886882008240 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 886882008241 Walker A/P-loop; other site 886882008242 ATP binding site [chemical binding]; other site 886882008243 Q-loop/lid; other site 886882008244 ABC transporter signature motif; other site 886882008245 Walker B; other site 886882008246 D-loop; other site 886882008247 H-loop/switch region; other site 886882008248 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 886882008249 catalytic residues [active] 886882008250 AP endonuclease family 2; Region: AP2Ec; smart00518 886882008251 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 886882008252 AP (apurinic/apyrimidinic) site pocket; other site 886882008253 DNA interaction; other site 886882008254 Metal-binding active site; metal-binding site 886882008255 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 886882008256 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 886882008257 DNA binding site [nucleotide binding] 886882008258 catalytic residue [active] 886882008259 H2TH interface [polypeptide binding]; other site 886882008260 putative catalytic residues [active] 886882008261 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 886882008262 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 886882008263 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882008264 active site 886882008265 motif I; other site 886882008266 motif II; other site 886882008267 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882008268 ribonuclease Z; Region: RNase_Z; TIGR02651 886882008269 5-methyltetrahydrofolate--homocysteine methyltransferase; Region: metH; TIGR02082 886882008270 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 886882008271 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 886882008272 substrate binding pocket [chemical binding]; other site 886882008273 dimer interface [polypeptide binding]; other site 886882008274 inhibitor binding site; inhibition site 886882008275 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 886882008276 B12 binding site [chemical binding]; other site 886882008277 cobalt ligand [ion binding]; other site 886882008278 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 886882008279 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 886882008280 Cupin domain; Region: Cupin_2; pfam07883 886882008281 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 886882008282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882008283 motif II; other site 886882008284 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 886882008285 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 886882008286 LexA repressor; Validated; Region: PRK00215 886882008287 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882008288 putative DNA binding site [nucleotide binding]; other site 886882008289 putative Zn2+ binding site [ion binding]; other site 886882008290 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 886882008291 Catalytic site [active] 886882008292 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 886882008293 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 886882008294 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 886882008295 active site 886882008296 L-aspartate oxidase; Provisional; Region: PRK06175 886882008297 FAD binding domain; Region: FAD_binding_2; pfam00890 886882008298 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 886882008299 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 886882008300 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 886882008301 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882008302 Interdomain contacts; other site 886882008303 Cytokine receptor motif; other site 886882008304 Transposase; Region: HTH_Tnp_1; cl17663 886882008305 putative transposase OrfB; Reviewed; Region: PHA02517 886882008306 HTH-like domain; Region: HTH_21; pfam13276 886882008307 Integrase core domain; Region: rve; pfam00665 886882008308 Integrase core domain; Region: rve_3; pfam13683 886882008309 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 886882008310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882008311 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 886882008312 DNA-binding interface [nucleotide binding]; DNA binding site 886882008313 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 886882008314 active site 886882008315 DNA binding site [nucleotide binding] 886882008316 Int/Topo IB signature motif; other site 886882008317 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 886882008318 Holin family; Region: Phage_holin_4; cl01989 886882008319 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 886882008320 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 886882008321 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 886882008322 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 886882008323 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 886882008324 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 886882008325 glutamine synthetase, type I; Region: GlnA; TIGR00653 886882008326 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 886882008327 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 886882008328 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 886882008329 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 886882008330 DNA binding residues [nucleotide binding] 886882008331 putative dimer interface [polypeptide binding]; other site 886882008332 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 886882008333 Aluminium resistance protein; Region: Alum_res; pfam06838 886882008334 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 886882008335 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 886882008336 HflX GTPase family; Region: HflX; cd01878 886882008337 G1 box; other site 886882008338 GTP/Mg2+ binding site [chemical binding]; other site 886882008339 Switch I region; other site 886882008340 G2 box; other site 886882008341 G3 box; other site 886882008342 Switch II region; other site 886882008343 G4 box; other site 886882008344 G5 box; other site 886882008345 stage V sporulation protein K; Region: spore_V_K; TIGR02881 886882008346 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882008347 Walker A motif; other site 886882008348 ATP binding site [chemical binding]; other site 886882008349 Walker B motif; other site 886882008350 arginine finger; other site 886882008351 Uncharacterized conserved protein [Function unknown]; Region: COG1434 886882008352 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 886882008353 putative active site [active] 886882008354 Protein of unknown function (DUF402); Region: DUF402; cl00979 886882008355 Transglycosylase; Region: Transgly; pfam00912 886882008356 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 886882008357 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 886882008358 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882008359 Interdomain contacts; other site 886882008360 Cytokine receptor motif; other site 886882008361 bacterial Hfq-like; Region: Hfq; cd01716 886882008362 hexamer interface [polypeptide binding]; other site 886882008363 Sm1 motif; other site 886882008364 RNA binding site [nucleotide binding]; other site 886882008365 Sm2 motif; other site 886882008366 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 886882008367 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 886882008368 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 886882008369 DNA mismatch repair enzyme (predicted ATPase) [DNA replication, recombination, and repair]; Region: MutL; COG0323 886882008370 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882008371 ATP binding site [chemical binding]; other site 886882008372 Mg2+ binding site [ion binding]; other site 886882008373 G-X-G motif; other site 886882008374 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 886882008375 ATP binding site [chemical binding]; other site 886882008376 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 886882008377 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 886882008378 MutS domain I; Region: MutS_I; pfam01624 886882008379 MutS domain II; Region: MutS_II; pfam05188 886882008380 MutS domain III; Region: MutS_III; pfam05192 886882008381 MutS domain V; Region: MutS_V; pfam00488 886882008382 Walker A/P-loop; other site 886882008383 ATP binding site [chemical binding]; other site 886882008384 Q-loop/lid; other site 886882008385 ABC transporter signature motif; other site 886882008386 Walker B; other site 886882008387 D-loop; other site 886882008388 H-loop/switch region; other site 886882008389 Phage phiEco32-like COOH.NH2 ligase-type 2; Region: COOH-NH2_lig; pfam14395 886882008390 Outer spore coat protein E (CotE); Region: CotE; pfam10628 886882008391 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882008392 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882008393 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882008394 dimerization interface [polypeptide binding]; other site 886882008395 putative transporter; Provisional; Region: PRK11021 886882008396 Predicted membrane protein [Function unknown]; Region: COG4129 886882008397 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 886882008398 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 886882008399 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 886882008400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882008401 dimer interface [polypeptide binding]; other site 886882008402 conserved gate region; other site 886882008403 putative PBP binding loops; other site 886882008404 ABC-ATPase subunit interface; other site 886882008405 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 886882008406 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 886882008407 Walker A/P-loop; other site 886882008408 ATP binding site [chemical binding]; other site 886882008409 Q-loop/lid; other site 886882008410 ABC transporter signature motif; other site 886882008411 Walker B; other site 886882008412 D-loop; other site 886882008413 H-loop/switch region; other site 886882008414 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 886882008415 NMT1-like family; Region: NMT1_2; pfam13379 886882008416 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 886882008417 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 886882008418 active site 886882008419 Zn binding site [ion binding]; other site 886882008420 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 886882008421 active site clefts [active] 886882008422 zinc binding site [ion binding]; other site 886882008423 dimer interface [polypeptide binding]; other site 886882008424 Predicted transcriptional regulators [Transcription]; Region: COG1695 886882008425 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 886882008426 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 886882008427 Protein of unknown function (DUF2653); Region: DUF2653; pfam10850 886882008428 coproporphyrinogen III oxidase; Validated; Region: PRK08208 886882008429 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882008430 FeS/SAM binding site; other site 886882008431 HemN C-terminal domain; Region: HemN_C; pfam06969 886882008432 Sulfatase; Region: Sulfatase; cl17466 886882008433 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 886882008434 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 886882008435 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 886882008436 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 886882008437 HlyD family secretion protein; Region: HlyD_3; pfam13437 886882008438 putative membrane fusion protein; Region: TIGR02828 886882008439 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 886882008440 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882008441 putative substrate translocation pore; other site 886882008442 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 886882008443 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 886882008444 E3 interaction surface; other site 886882008445 lipoyl attachment site [posttranslational modification]; other site 886882008446 HlyD family secretion protein; Region: HlyD_3; pfam13437 886882008447 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 886882008448 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 886882008449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882008450 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 886882008451 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 886882008452 active site 886882008453 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882008454 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882008455 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882008456 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882008457 MarR family; Region: MarR; pfam01047 886882008458 Transcriptional regulators [Transcription]; Region: MarR; COG1846 886882008459 MarR family; Region: MarR; pfam01047 886882008460 DNA gyrase subunit A; Validated; Region: PRK05560 886882008461 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 886882008462 CAP-like domain; other site 886882008463 active site 886882008464 primary dimer interface [polypeptide binding]; other site 886882008465 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 886882008466 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 886882008467 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 886882008468 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 886882008469 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 886882008470 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882008471 ATP binding site [chemical binding]; other site 886882008472 Mg2+ binding site [ion binding]; other site 886882008473 G-X-G motif; other site 886882008474 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 886882008475 anchoring element; other site 886882008476 dimer interface [polypeptide binding]; other site 886882008477 ATP binding site [chemical binding]; other site 886882008478 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 886882008479 active site 886882008480 metal binding site [ion binding]; metal-binding site 886882008481 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 886882008482 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 886882008483 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 886882008484 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 886882008485 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 886882008486 Walker A/P-loop; other site 886882008487 ATP binding site [chemical binding]; other site 886882008488 Q-loop/lid; other site 886882008489 ABC transporter signature motif; other site 886882008490 Walker B; other site 886882008491 D-loop; other site 886882008492 H-loop/switch region; other site 886882008493 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 886882008494 active site 886882008495 catalytic triad [active] 886882008496 oxyanion hole [active] 886882008497 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 886882008498 Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340 886882008499 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 886882008500 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882008501 Coenzyme A binding pocket [chemical binding]; other site 886882008502 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 886882008503 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882008504 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 886882008505 ATP-grasp domain; Region: ATP-grasp; pfam02222 886882008506 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882008507 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882008508 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 886882008509 Walker A/P-loop; other site 886882008510 ATP binding site [chemical binding]; other site 886882008511 Q-loop/lid; other site 886882008512 ABC transporter signature motif; other site 886882008513 Walker B; other site 886882008514 D-loop; other site 886882008515 H-loop/switch region; other site 886882008516 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882008517 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882008518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882008519 Walker A/P-loop; other site 886882008520 ATP binding site [chemical binding]; other site 886882008521 Q-loop/lid; other site 886882008522 ABC transporter signature motif; other site 886882008523 Walker B; other site 886882008524 D-loop; other site 886882008525 H-loop/switch region; other site 886882008526 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 886882008527 Dynamin family; Region: Dynamin_N; pfam00350 886882008528 G1 box; other site 886882008529 GTP/Mg2+ binding site [chemical binding]; other site 886882008530 G2 box; other site 886882008531 Switch I region; other site 886882008532 G3 box; other site 886882008533 Switch II region; other site 886882008534 G4 box; other site 886882008535 G5 box; other site 886882008536 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 886882008537 Dynamin family; Region: Dynamin_N; pfam00350 886882008538 G1 box; other site 886882008539 GTP/Mg2+ binding site [chemical binding]; other site 886882008540 G2 box; other site 886882008541 Switch I region; other site 886882008542 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 886882008543 G3 box; other site 886882008544 Switch II region; other site 886882008545 GTP/Mg2+ binding site [chemical binding]; other site 886882008546 G4 box; other site 886882008547 G5 box; other site 886882008548 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 886882008549 catalytic residues [active] 886882008550 dimer interface [polypeptide binding]; other site 886882008551 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 886882008552 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 886882008553 minor groove reading motif; other site 886882008554 helix-hairpin-helix signature motif; other site 886882008555 substrate binding pocket [chemical binding]; other site 886882008556 active site 886882008557 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 886882008558 Sporulation and spore germination; Region: Germane; pfam10646 886882008559 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882008560 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 886882008561 AMIN domain; Region: AMIN; pfam11741 886882008562 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 886882008563 active site 886882008564 metal binding site [ion binding]; metal-binding site 886882008565 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882008566 AMIN domain; Region: AMIN; pfam11741 886882008567 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 886882008568 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 886882008569 active site 886882008570 metal binding site [ion binding]; metal-binding site 886882008571 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 886882008572 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 886882008573 substrate binding site [chemical binding]; other site 886882008574 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 886882008575 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 886882008576 substrate binding site [chemical binding]; other site 886882008577 ligand binding site [chemical binding]; other site 886882008578 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 886882008579 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 886882008580 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 886882008581 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 886882008582 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 886882008583 active site 886882008584 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 886882008585 active site 886882008586 catalytic site [active] 886882008587 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 886882008588 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 886882008589 [4Fe-4S] binding site [ion binding]; other site 886882008590 molybdopterin cofactor binding site; other site 886882008591 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 886882008592 molybdopterin cofactor binding site; other site 886882008593 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 886882008594 4Fe-4S binding domain; Region: Fer4; pfam00037 886882008595 Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906 886882008596 Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256 886882008597 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 886882008598 4Fe-4S binding domain; Region: Fer4; pfam00037 886882008599 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 886882008600 Aspartase; Region: Aspartase; cd01357 886882008601 active sites [active] 886882008602 tetramer interface [polypeptide binding]; other site 886882008603 [FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918 886882008604 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 886882008605 G1 box; other site 886882008606 GTP/Mg2+ binding site [chemical binding]; other site 886882008607 Switch I region; other site 886882008608 G2 box; other site 886882008609 Switch II region; other site 886882008610 G3 box; other site 886882008611 G4 box; other site 886882008612 G5 box; other site 886882008613 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613 886882008614 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882008615 FeS/SAM binding site; other site 886882008616 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 886882008617 biotin synthase; Provisional; Region: PRK07094 886882008618 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882008619 FeS/SAM binding site; other site 886882008620 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 886882008621 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 886882008622 Alkaline phosphatase homologues; Region: alkPPc; smart00098 886882008623 active site 886882008624 dimer interface [polypeptide binding]; other site 886882008625 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882008626 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882008627 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882008628 dimerization interface [polypeptide binding]; other site 886882008629 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882008630 non-specific DNA binding site [nucleotide binding]; other site 886882008631 salt bridge; other site 886882008632 sequence-specific DNA binding site [nucleotide binding]; other site 886882008633 Predicted amidohydrolase [General function prediction only]; Region: COG0388 886882008634 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 886882008635 putative active site [active] 886882008636 catalytic triad [active] 886882008637 putative dimer interface [polypeptide binding]; other site 886882008638 transaminase; Reviewed; Region: PRK08068 886882008639 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882008640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882008641 homodimer interface [polypeptide binding]; other site 886882008642 catalytic residue [active] 886882008643 gamma-glutamyl kinase; Provisional; Region: PRK05429 886882008644 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 886882008645 nucleotide binding site [chemical binding]; other site 886882008646 homotetrameric interface [polypeptide binding]; other site 886882008647 putative phosphate binding site [ion binding]; other site 886882008648 putative allosteric binding site; other site 886882008649 PUA domain; Region: PUA; pfam01472 886882008650 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 886882008651 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 886882008652 putative catalytic cysteine [active] 886882008653 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 886882008654 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 886882008655 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Reviewed; Region: mtnW; PRK09549 886882008656 2,3-diketo-5-methylthiopentyl-1-phosphate enolase; Region: RLP_DK-MTP-1-P-enolase; cd08209 886882008657 dimer interface [polypeptide binding]; other site 886882008658 active site 886882008659 catalytic residue [active] 886882008660 metal binding site [ion binding]; metal-binding site 886882008661 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 886882008662 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882008663 active site 886882008664 motif I; other site 886882008665 motif II; other site 886882008666 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 886882008667 intersubunit interface [polypeptide binding]; other site 886882008668 active site 886882008669 Zn2+ binding site [ion binding]; other site 886882008670 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 886882008671 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 886882008672 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882008673 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882008674 DNA binding residues [nucleotide binding] 886882008675 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 886882008676 Helix-turn-helix domain; Region: HTH_36; pfam13730 886882008677 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 886882008678 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 886882008679 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 886882008680 putative dimer interface [polypeptide binding]; other site 886882008681 putative anticodon binding site; other site 886882008682 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 886882008683 homodimer interface [polypeptide binding]; other site 886882008684 motif 1; other site 886882008685 motif 2; other site 886882008686 active site 886882008687 motif 3; other site 886882008688 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 886882008689 propionate/acetate kinase; Provisional; Region: PRK12379 886882008690 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 886882008691 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 886882008692 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 886882008693 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 886882008694 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882008695 Walker A motif; other site 886882008696 ATP binding site [chemical binding]; other site 886882008697 Walker B motif; other site 886882008698 arginine finger; other site 886882008699 Peptidase family M41; Region: Peptidase_M41; pfam01434 886882008700 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 886882008701 N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038 886882008702 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 886882008703 active site 886882008704 putative substrate binding pocket [chemical binding]; other site 886882008705 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 886882008706 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 886882008707 CoA binding domain; Region: CoA_binding; smart00881 886882008708 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 886882008709 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 886882008710 active site 886882008711 catalytic site [active] 886882008712 substrate binding site [chemical binding]; other site 886882008713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 886882008714 ATP binding site [chemical binding]; other site 886882008715 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 886882008716 putative Mg++ binding site [ion binding]; other site 886882008717 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 886882008718 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 886882008719 binding surface 886882008720 Tetratricopeptide repeat; Region: TPR_16; pfam13432 886882008721 TPR motif; other site 886882008722 TPR repeat; Region: TPR_11; pfam13414 886882008723 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 886882008724 tetramerization interface [polypeptide binding]; other site 886882008725 active site 886882008726 pantoate--beta-alanine ligase; Region: panC; TIGR00018 886882008727 Pantoate-beta-alanine ligase; Region: PanC; cd00560 886882008728 active site 886882008729 ATP-binding site [chemical binding]; other site 886882008730 pantoate-binding site; other site 886882008731 HXXH motif; other site 886882008732 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 886882008733 oligomerization interface [polypeptide binding]; other site 886882008734 active site 886882008735 metal binding site [ion binding]; metal-binding site 886882008736 Biotin operon repressor [Transcription]; Region: BirA; COG1654 886882008737 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 886882008738 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 886882008739 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 886882008740 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 886882008741 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 886882008742 active site 886882008743 NTP binding site [chemical binding]; other site 886882008744 metal binding triad [ion binding]; metal-binding site 886882008745 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 886882008746 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 886882008747 N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999 886882008748 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962 886882008749 bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001 886882008750 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 886882008751 active site 886882008752 dimer interfaces [polypeptide binding]; other site 886882008753 catalytic residues [active] 886882008754 dihydrodipicolinate reductase; Provisional; Region: PRK00048 886882008755 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 886882008756 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 886882008757 TPR repeat; Region: TPR_11; pfam13414 886882008758 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 886882008759 binding surface 886882008760 TPR motif; other site 886882008761 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 886882008762 TPR motif; other site 886882008763 binding surface 886882008764 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531 886882008765 homodimer interface [polypeptide binding]; other site 886882008766 metal binding site [ion binding]; metal-binding site 886882008767 Uncharacterized conserved protein [Function unknown]; Region: COG1284 886882008768 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 886882008769 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 886882008770 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 886882008771 Sporulation protein YpjB (SpoYpjB); Region: Spore_YpjB; cl09800 886882008772 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882008773 Coenzyme A binding pocket [chemical binding]; other site 886882008774 Protein of unknown function (DUF1405); Region: DUF1405; cl01798 886882008775 IDEAL domain; Region: IDEAL; cl07452 886882008776 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 886882008777 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 886882008778 trimer interface [polypeptide binding]; other site 886882008779 putative metal binding site [ion binding]; other site 886882008780 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 886882008781 catalytic core [active] 886882008782 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 886882008783 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882008784 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882008785 DNA binding residues [nucleotide binding] 886882008786 Methyltransferase domain; Region: Methyltransf_31; pfam13847 886882008787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882008788 S-adenosylmethionine binding site [chemical binding]; other site 886882008789 prephenate dehydrogenase; Validated; Region: PRK08507 886882008790 prephenate dehydrogenase; Validated; Region: PRK06545 886882008791 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 886882008792 histidinol-phosphate aminotransferase; Provisional; Region: PRK03158 886882008793 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882008794 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882008795 homodimer interface [polypeptide binding]; other site 886882008796 catalytic residue [active] 886882008797 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 886882008798 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 886882008799 substrate binding site [chemical binding]; other site 886882008800 active site 886882008801 catalytic residues [active] 886882008802 heterodimer interface [polypeptide binding]; other site 886882008803 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 886882008804 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 886882008805 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882008806 catalytic residue [active] 886882008807 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 886882008808 active site 886882008809 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 886882008810 active site 886882008811 ribulose/triose binding site [chemical binding]; other site 886882008812 phosphate binding site [ion binding]; other site 886882008813 substrate (anthranilate) binding pocket [chemical binding]; other site 886882008814 product (indole) binding pocket [chemical binding]; other site 886882008815 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 886882008816 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 886882008817 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 886882008818 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 886882008819 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 886882008820 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 886882008821 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 886882008822 homotrimer interaction site [polypeptide binding]; other site 886882008823 active site 886882008824 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 886882008825 active site 886882008826 dimer interface [polypeptide binding]; other site 886882008827 metal binding site [ion binding]; metal-binding site 886882008828 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 886882008829 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 886882008830 Tetramer interface [polypeptide binding]; other site 886882008831 active site 886882008832 FMN-binding site [chemical binding]; other site 886882008833 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 886882008834 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 886882008835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882008836 S-adenosylmethionine binding site [chemical binding]; other site 886882008837 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 886882008838 active site 886882008839 multimer interface [polypeptide binding]; other site 886882008840 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 886882008841 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 886882008842 substrate binding pocket [chemical binding]; other site 886882008843 chain length determination region; other site 886882008844 substrate-Mg2+ binding site; other site 886882008845 catalytic residues [active] 886882008846 aspartate-rich region 1; other site 886882008847 active site lid residues [active] 886882008848 aspartate-rich region 2; other site 886882008849 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 886882008850 aromatic acid decarboxylase; Validated; Region: PRK05920 886882008851 Flavoprotein; Region: Flavoprotein; pfam02441 886882008852 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 886882008853 UbiA prenyltransferase family; Region: UbiA; pfam01040 886882008854 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 886882008855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882008856 S-adenosylmethionine binding site [chemical binding]; other site 886882008857 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1; Region: HEPPP_synt_1; pfam07307 886882008858 Tryptophan RNA-binding attenuator protein; Region: TrpBP; cl03437 886882008859 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 886882008860 IHF - DNA interface [nucleotide binding]; other site 886882008861 IHF dimer interface [polypeptide binding]; other site 886882008862 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 886882008863 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 886882008864 TM-ABC transporter signature motif; other site 886882008865 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 886882008866 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 886882008867 Walker A/P-loop; other site 886882008868 ATP binding site [chemical binding]; other site 886882008869 Q-loop/lid; other site 886882008870 ABC transporter signature motif; other site 886882008871 Walker B; other site 886882008872 D-loop; other site 886882008873 H-loop/switch region; other site 886882008874 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 886882008875 Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305 886882008876 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 886882008877 putative ligand binding site [chemical binding]; other site 886882008878 stage IV sporulation protein A; Region: spore_IV_A; TIGR02836 886882008879 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 886882008880 G1 box; other site 886882008881 GTP/Mg2+ binding site [chemical binding]; other site 886882008882 G2 box; other site 886882008883 Switch I region; other site 886882008884 G3 box; other site 886882008885 Switch II region; other site 886882008886 G4 box; other site 886882008887 G5 box; other site 886882008888 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 886882008889 catalytic loop [active] 886882008890 iron binding site [ion binding]; other site 886882008891 HTH-like domain; Region: HTH_21; pfam13276 886882008892 Integrase core domain; Region: rve; pfam00665 886882008893 Integrase core domain; Region: rve_3; pfam13683 886882008894 Transposase; Region: HTH_Tnp_1; cl17663 886882008895 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 886882008896 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 886882008897 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 886882008898 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 886882008899 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 886882008900 GTP-binding protein Der; Reviewed; Region: PRK00093 886882008901 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 886882008902 G1 box; other site 886882008903 GTP/Mg2+ binding site [chemical binding]; other site 886882008904 Switch I region; other site 886882008905 G2 box; other site 886882008906 Switch II region; other site 886882008907 G3 box; other site 886882008908 G4 box; other site 886882008909 G5 box; other site 886882008910 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 886882008911 G1 box; other site 886882008912 GTP/Mg2+ binding site [chemical binding]; other site 886882008913 Switch I region; other site 886882008914 G2 box; other site 886882008915 G3 box; other site 886882008916 Switch II region; other site 886882008917 G4 box; other site 886882008918 G5 box; other site 886882008919 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 886882008920 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 886882008921 RNA binding site [nucleotide binding]; other site 886882008922 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 886882008923 RNA binding site [nucleotide binding]; other site 886882008924 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 886882008925 RNA binding site [nucleotide binding]; other site 886882008926 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 886882008927 RNA binding site [nucleotide binding]; other site 886882008928 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 886882008929 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 886882008930 putative acyl-acceptor binding pocket; other site 886882008931 cytidylate kinase; Provisional; Region: cmk; PRK00023 886882008932 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 886882008933 CMP-binding site; other site 886882008934 The sites determining sugar specificity; other site 886882008935 Flagellar protein YcgR; Region: YcgR_2; pfam12945 886882008936 PilZ domain; Region: PilZ; pfam07238 886882008937 germination protein YpeB; Region: spore_YpeB; TIGR02889 886882008938 Protease prsW family; Region: PrsW-protease; pfam13367 886882008939 Negative regulator of genetic competence (MecA); Region: MecA; cl02022 886882008940 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 886882008941 NodB motif; other site 886882008942 active site 886882008943 catalytic site [active] 886882008944 metal binding site [ion binding]; metal-binding site 886882008945 CAAX protease self-immunity; Region: Abi; pfam02517 886882008946 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 886882008947 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 886882008948 ligand binding site [chemical binding]; other site 886882008949 NAD binding site [chemical binding]; other site 886882008950 dimerization interface [polypeptide binding]; other site 886882008951 catalytic site [active] 886882008952 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 886882008953 putative L-serine binding site [chemical binding]; other site 886882008954 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882008955 dimerization interface [polypeptide binding]; other site 886882008956 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 886882008957 PAS domain; Region: PAS; smart00091 886882008958 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882008959 dimer interface [polypeptide binding]; other site 886882008960 phosphorylation site [posttranslational modification] 886882008961 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882008962 ATP binding site [chemical binding]; other site 886882008963 Mg2+ binding site [ion binding]; other site 886882008964 G-X-G motif; other site 886882008965 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882008966 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882008967 active site 886882008968 phosphorylation site [posttranslational modification] 886882008969 intermolecular recognition site; other site 886882008970 dimerization interface [polypeptide binding]; other site 886882008971 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882008972 DNA binding site [nucleotide binding] 886882008973 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 886882008974 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 886882008975 RNA binding surface [nucleotide binding]; other site 886882008976 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 886882008977 active site 886882008978 Uncharacterized membrane protein [Function unknown]; Region: SpmB; cl17667 886882008979 Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715 886882008980 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 886882008981 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 886882008982 transglutaminase; Provisional; Region: tgl; PRK03187 886882008983 sporulation protein YtfJ; Region: spore_ytfJ; TIGR02874 886882008984 Protein of unknown function (DUF2953); Region: DUF2953; pfam11167 886882008985 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 886882008986 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 886882008987 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 886882008988 homopentamer interface [polypeptide binding]; other site 886882008989 active site 886882008990 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 886882008991 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 886882008992 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 886882008993 Lumazine binding domain; Region: Lum_binding; pfam00677 886882008994 Lumazine binding domain; Region: Lum_binding; pfam00677 886882008995 IDEAL domain; Region: IDEAL; cl07452 886882008996 pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622 886882008997 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 886882008998 dimer interface [polypeptide binding]; other site 886882008999 PYR/PP interface [polypeptide binding]; other site 886882009000 TPP binding site [chemical binding]; other site 886882009001 substrate binding site [chemical binding]; other site 886882009002 pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865 886882009003 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 886882009004 TPP-binding site [chemical binding]; other site 886882009005 Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546 886882009006 pyruvate ferredoxin oxidoreductase subunit gamma/delta; Provisional; Region: PRK14028 886882009007 4Fe-4S binding domain; Region: Fer4; pfam00037 886882009008 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 886882009009 active site 886882009010 diaminopimelate decarboxylase; Region: lysA; TIGR01048 886882009011 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 886882009012 active site 886882009013 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 886882009014 substrate binding site [chemical binding]; other site 886882009015 catalytic residues [active] 886882009016 dimer interface [polypeptide binding]; other site 886882009017 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 886882009018 Stage V sporulation protein AB; Region: SpoVAB; pfam13782 886882009019 Stage V sporulation protein AA; Region: SporV_AA; pfam12164 886882009020 sporulation sigma factor SigF; Validated; Region: PRK05572 886882009021 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882009022 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 886882009023 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882009024 DNA binding residues [nucleotide binding] 886882009025 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 886882009026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882009027 ATP binding site [chemical binding]; other site 886882009028 Mg2+ binding site [ion binding]; other site 886882009029 G-X-G motif; other site 886882009030 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 886882009031 anti sigma factor interaction site; other site 886882009032 regulatory phosphorylation site [posttranslational modification]; other site 886882009033 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 886882009034 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 886882009035 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 886882009036 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 886882009037 purine nucleoside phosphorylase; Provisional; Region: PRK08202 886882009038 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 886882009039 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 886882009040 active site 886882009041 Int/Topo IB signature motif; other site 886882009042 Protein of unknown function (DUF4227); Region: DUF4227; pfam14004 886882009043 ferric uptake regulator; Provisional; Region: fur; PRK09462 886882009044 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 886882009045 metal binding site 2 [ion binding]; metal-binding site 886882009046 putative DNA binding helix; other site 886882009047 metal binding site 1 [ion binding]; metal-binding site 886882009048 dimer interface [polypeptide binding]; other site 886882009049 structural Zn2+ binding site [ion binding]; other site 886882009050 Integral membrane protein DUF95; Region: DUF95; cl00572 886882009051 PHP family phosphoesterase with a Zn ribbon [General function prediction only]; Region: COG1379 886882009052 PHP-associated; Region: PHP_C; pfam13263 886882009053 Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cd00350 886882009054 iron binding site [ion binding]; other site 886882009055 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 886882009056 dimer interface [polypeptide binding]; other site 886882009057 ADP-ribose binding site [chemical binding]; other site 886882009058 active site 886882009059 nudix motif; other site 886882009060 metal binding site [ion binding]; metal-binding site 886882009061 Protein of unknown function (DUF3936); Region: DUF3936; pfam13072 886882009062 M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683 886882009063 peptidase T-like protein; Region: PepT-like; TIGR01883 886882009064 metal binding site [ion binding]; metal-binding site 886882009065 putative dimer interface [polypeptide binding]; other site 886882009066 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 886882009067 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 886882009068 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 886882009069 E3 interaction surface; other site 886882009070 lipoyl attachment site [posttranslational modification]; other site 886882009071 e3 binding domain; Region: E3_binding; pfam02817 886882009072 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 886882009073 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 886882009074 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 886882009075 alpha subunit interface [polypeptide binding]; other site 886882009076 TPP binding site [chemical binding]; other site 886882009077 heterodimer interface [polypeptide binding]; other site 886882009078 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 886882009079 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 886882009080 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 886882009081 tetramer interface [polypeptide binding]; other site 886882009082 TPP-binding site [chemical binding]; other site 886882009083 heterodimer interface [polypeptide binding]; other site 886882009084 phosphorylation loop region [posttranslational modification] 886882009085 dihydrolipoamide dehydrogenase; Validated; Region: PRK05976 886882009086 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 886882009087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882009088 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 886882009089 thymidine kinase; Provisional; Region: PRK04296 886882009090 Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326 886882009091 SpoOM protein; Region: Spo0M; pfam07070 886882009092 putative transposase OrfB; Reviewed; Region: PHA02517 886882009093 HTH-like domain; Region: HTH_21; pfam13276 886882009094 Integrase core domain; Region: rve; pfam00665 886882009095 Integrase core domain; Region: rve_3; pfam13683 886882009096 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 886882009097 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882009098 dimerization interface [polypeptide binding]; other site 886882009099 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882009100 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882009101 dimer interface [polypeptide binding]; other site 886882009102 putative CheW interface [polypeptide binding]; other site 886882009103 Methyltransferase domain; Region: Methyltransf_31; pfam13847 886882009104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882009105 S-adenosylmethionine binding site [chemical binding]; other site 886882009106 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 886882009107 sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875 886882009108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882009109 active site 886882009110 phosphorylation site [posttranslational modification] 886882009111 intermolecular recognition site; other site 886882009112 dimerization interface [polypeptide binding]; other site 886882009113 Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769 886882009114 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 886882009115 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 886882009116 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 886882009117 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 886882009118 Walker A/P-loop; other site 886882009119 ATP binding site [chemical binding]; other site 886882009120 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 886882009121 ABC transporter signature motif; other site 886882009122 Walker B; other site 886882009123 D-loop; other site 886882009124 H-loop/switch region; other site 886882009125 arginine repressor; Provisional; Region: PRK04280 886882009126 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 886882009127 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 886882009128 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 886882009129 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 886882009130 RNA binding surface [nucleotide binding]; other site 886882009131 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 886882009132 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 886882009133 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 886882009134 TPP-binding site; other site 886882009135 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 886882009136 PYR/PP interface [polypeptide binding]; other site 886882009137 dimer interface [polypeptide binding]; other site 886882009138 TPP binding site [chemical binding]; other site 886882009139 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 886882009140 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 886882009141 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 886882009142 substrate binding pocket [chemical binding]; other site 886882009143 chain length determination region; other site 886882009144 substrate-Mg2+ binding site; other site 886882009145 catalytic residues [active] 886882009146 aspartate-rich region 1; other site 886882009147 active site lid residues [active] 886882009148 aspartate-rich region 2; other site 886882009149 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 886882009150 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 886882009151 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 886882009152 generic binding surface II; other site 886882009153 generic binding surface I; other site 886882009154 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 886882009155 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 886882009156 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 886882009157 homodimer interface [polypeptide binding]; other site 886882009158 NADP binding site [chemical binding]; other site 886882009159 substrate binding site [chemical binding]; other site 886882009160 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 886882009161 putative RNA binding site [nucleotide binding]; other site 886882009162 Small integral membrane protein (DUF2273); Region: DUF2273; pfam10031 886882009163 Asp23 family; Region: Asp23; cl00574 886882009164 Asp23 family; Region: Asp23; pfam03780 886882009165 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 886882009166 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 886882009167 ATP-grasp domain; Region: ATP-grasp_4; cl17255 886882009168 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 886882009169 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 886882009170 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 886882009171 carboxyltransferase (CT) interaction site; other site 886882009172 biotinylation site [posttranslational modification]; other site 886882009173 SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685 886882009174 stage III sporulation protein AG; Region: spore_III_AG; TIGR02830 886882009175 Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581 886882009176 Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546 886882009177 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 886882009178 Stage III sporulation protein AC/AD protein family; Region: SpoIIIAC; cl05961 886882009179 stage III sporulation protein SpoAB; Provisional; Region: PRK08307 886882009180 stage III sporulation protein AA; Region: spore_III_AA; TIGR02858 886882009181 NTPase; Region: NTPase_1; cl17478 886882009182 aspartate kinase; Reviewed; Region: PRK06635 886882009183 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 886882009184 putative catalytic residues [active] 886882009185 putative nucleotide binding site [chemical binding]; other site 886882009186 putative aspartate binding site [chemical binding]; other site 886882009187 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 886882009188 putative allosteric regulatory site; other site 886882009189 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 886882009190 elongation factor P; Validated; Region: PRK00529 886882009191 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 886882009192 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 886882009193 RNA binding site [nucleotide binding]; other site 886882009194 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 886882009195 RNA binding site [nucleotide binding]; other site 886882009196 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 886882009197 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 886882009198 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 886882009199 active site 886882009200 Conserved membrane protein YqhR; Region: YqhR; pfam11085 886882009201 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 886882009202 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 886882009203 siderophore binding site; other site 886882009204 Predicted metal-dependent enzyme [General function prediction only]; Region: COG3872 886882009205 Oxygen tolerance; Region: BatD; pfam13584 886882009206 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 886882009207 ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207 886882009208 active site 886882009209 nucleophile elbow; other site 886882009210 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882009211 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 886882009212 manganese transport transcriptional regulator; Provisional; Region: PRK03902 886882009213 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 886882009214 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 886882009215 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 886882009216 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882009217 FeS/SAM binding site; other site 886882009218 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 886882009219 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 886882009220 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 886882009221 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 886882009222 active site 886882009223 HIGH motif; other site 886882009224 KMSKS motif; other site 886882009225 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 886882009226 tRNA binding surface [nucleotide binding]; other site 886882009227 anticodon binding site; other site 886882009228 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 886882009229 dimer interface [polypeptide binding]; other site 886882009230 putative tRNA-binding site [nucleotide binding]; other site 886882009231 Haemolytic domain; Region: Haemolytic; pfam01809 886882009232 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 886882009233 metal binding site 2 [ion binding]; metal-binding site 886882009234 putative DNA binding helix; other site 886882009235 metal binding site 1 [ion binding]; metal-binding site 886882009236 dimer interface [polypeptide binding]; other site 886882009237 structural Zn2+ binding site [ion binding]; other site 886882009238 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882009239 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 886882009240 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882009241 FeS/SAM binding site; other site 886882009242 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 886882009243 Pyruvate formate lyase 1; Region: PFL1; cd01678 886882009244 coenzyme A binding site [chemical binding]; other site 886882009245 active site 886882009246 catalytic residues [active] 886882009247 glycine loop; other site 886882009248 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 886882009249 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 886882009250 putative catalytic cysteine [active] 886882009251 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 886882009252 putative active site [active] 886882009253 metal binding site [ion binding]; metal-binding site 886882009254 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 886882009255 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 886882009256 ligand binding site [chemical binding]; other site 886882009257 flexible hinge region; other site 886882009258 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 886882009259 non-specific DNA interactions [nucleotide binding]; other site 886882009260 DNA binding site [nucleotide binding] 886882009261 sequence specific DNA binding site [nucleotide binding]; other site 886882009262 putative cAMP binding site [chemical binding]; other site 886882009263 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 886882009264 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 886882009265 putative active site [active] 886882009266 metal binding site [ion binding]; metal-binding site 886882009267 flagellar operon protein TIGR03826; Region: YvyF 886882009268 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882009269 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 886882009270 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 886882009271 conserved cys residue [active] 886882009272 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 886882009273 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 886882009274 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 886882009275 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882009276 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 886882009277 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 886882009278 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882009279 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882009280 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882009281 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882009282 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 886882009283 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 886882009284 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 886882009285 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882009286 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 886882009287 Uncharacterized conserved protein [Function unknown]; Region: COG0398 886882009288 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 886882009289 methionine sulfoxide reductase A; Provisional; Region: PRK14054 886882009290 methionine sulfoxide reductase B; Provisional; Region: PRK00222 886882009291 SelR domain; Region: SelR; pfam01641 886882009292 Protein of unknown function (DUF2837); Region: DUF2837; pfam10997 886882009293 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 886882009294 Uncharacterized conserved protein [Function unknown]; Region: COG1284 886882009295 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 886882009296 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 886882009297 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 886882009298 EamA-like transporter family; Region: EamA; pfam00892 886882009299 Transglycosylase; Region: Transgly; pfam00912 886882009300 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 886882009301 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 886882009302 DNA polymerase IV; Reviewed; Region: PRK03103 886882009303 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 886882009304 active site 886882009305 DNA binding site [nucleotide binding] 886882009306 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 886882009307 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882009308 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882009309 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882009310 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882009311 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 886882009312 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882009313 Stage VI sporulation protein F; Region: SpoVIF; pfam14069 886882009314 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 886882009315 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 886882009316 generic binding surface II; other site 886882009317 ssDNA binding site; other site 886882009318 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 886882009319 ATP binding site [chemical binding]; other site 886882009320 putative Mg++ binding site [ion binding]; other site 886882009321 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882009322 nucleotide binding region [chemical binding]; other site 886882009323 ATP-binding site [chemical binding]; other site 886882009324 EDD domain protein, DegV family; Region: DegV; TIGR00762 886882009325 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 886882009326 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 886882009327 DAK2 domain; Region: Dak2; pfam02734 886882009328 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 886882009329 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 886882009330 substrate binding site [chemical binding]; other site 886882009331 hexamer interface [polypeptide binding]; other site 886882009332 metal binding site [ion binding]; metal-binding site 886882009333 GTPase RsgA; Reviewed; Region: PRK00098 886882009334 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 886882009335 RNA binding site [nucleotide binding]; other site 886882009336 homodimer interface [polypeptide binding]; other site 886882009337 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 886882009338 GTPase/Zn-binding domain interface [polypeptide binding]; other site 886882009339 GTP/Mg2+ binding site [chemical binding]; other site 886882009340 G4 box; other site 886882009341 G5 box; other site 886882009342 G1 box; other site 886882009343 Switch I region; other site 886882009344 G2 box; other site 886882009345 G3 box; other site 886882009346 Switch II region; other site 886882009347 Catalytic domain of Protein Kinases; Region: PKc; cd00180 886882009348 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 886882009349 active site 886882009350 ATP binding site [chemical binding]; other site 886882009351 substrate binding site [chemical binding]; other site 886882009352 activation loop (A-loop); other site 886882009353 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 886882009354 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 886882009355 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 886882009356 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 886882009357 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 886882009358 active site 886882009359 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 886882009360 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882009361 FeS/SAM binding site; other site 886882009362 16S rRNA methyltransferase B; Provisional; Region: PRK14902 886882009363 NusB family; Region: NusB; pfam01029 886882009364 putative RNA binding site [nucleotide binding]; other site 886882009365 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882009366 S-adenosylmethionine binding site [chemical binding]; other site 886882009367 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 886882009368 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 886882009369 putative active site [active] 886882009370 substrate binding site [chemical binding]; other site 886882009371 putative cosubstrate binding site; other site 886882009372 catalytic site [active] 886882009373 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 886882009374 substrate binding site [chemical binding]; other site 886882009375 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 886882009376 active site 886882009377 catalytic residues [active] 886882009378 metal binding site [ion binding]; metal-binding site 886882009379 primosomal protein N' Region: priA; TIGR00595 886882009380 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 886882009381 ATP binding site [chemical binding]; other site 886882009382 putative Mg++ binding site [ion binding]; other site 886882009383 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882009384 nucleotide binding region [chemical binding]; other site 886882009385 ATP-binding site [chemical binding]; other site 886882009386 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 886882009387 Flavoprotein; Region: Flavoprotein; pfam02441 886882009388 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 886882009389 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 886882009390 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 886882009391 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 886882009392 catalytic site [active] 886882009393 G-X2-G-X-G-K; other site 886882009394 hypothetical protein; Provisional; Region: PRK04323 886882009395 hypothetical protein; Provisional; Region: PRK11820 886882009396 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 886882009397 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 886882009398 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 886882009399 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 886882009400 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 886882009401 FAD binding site [chemical binding]; other site 886882009402 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 886882009403 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 886882009404 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 886882009405 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 886882009406 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 886882009407 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 886882009408 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 886882009409 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882009410 motif II; other site 886882009411 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 886882009412 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 886882009413 Domain of unknown function (DUF814); Region: DUF814; pfam05670 886882009414 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 886882009415 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 886882009416 active site 886882009417 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 886882009418 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882009419 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882009420 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 886882009421 putative dimerization interface [polypeptide binding]; other site 886882009422 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 886882009423 Protein of unknown function (DUF964); Region: DUF964; pfam06133 886882009424 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 886882009425 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 886882009426 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 886882009427 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 886882009428 ATP binding site [chemical binding]; other site 886882009429 putative Mg++ binding site [ion binding]; other site 886882009430 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882009431 nucleotide binding region [chemical binding]; other site 886882009432 ATP-binding site [chemical binding]; other site 886882009433 FOG: CBS domain [General function prediction only]; Region: COG0517 886882009434 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_9; cd04622 886882009435 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 886882009436 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 886882009437 metal binding site [ion binding]; metal-binding site 886882009438 dimer interface [polypeptide binding]; other site 886882009439 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 886882009440 Asp23 family; Region: Asp23; pfam03780 886882009441 calcium/proton exchanger (cax); Region: cax; TIGR00378 886882009442 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 886882009443 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 886882009444 hypothetical protein; Provisional; Region: PRK13666 886882009445 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 886882009446 regulatory protein interface [polypeptide binding]; other site 886882009447 regulatory phosphorylation site [posttranslational modification]; other site 886882009448 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 886882009449 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 886882009450 GAF domain; Region: GAF_3; pfam13492 886882009451 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 886882009452 GAF domain; Region: GAF; pfam01590 886882009453 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 886882009454 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 886882009455 metal binding site [ion binding]; metal-binding site 886882009456 active site 886882009457 I-site; other site 886882009458 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 886882009459 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 886882009460 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 886882009461 RNA binding surface [nucleotide binding]; other site 886882009462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882009463 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882009464 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882009465 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 886882009466 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 886882009467 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 886882009468 active site 886882009469 HIGH motif; other site 886882009470 dimer interface [polypeptide binding]; other site 886882009471 KMSKS motif; other site 886882009472 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 886882009473 RNA binding surface [nucleotide binding]; other site 886882009474 Transglycosylase; Region: Transgly; pfam00912 886882009475 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 886882009476 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 886882009477 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882009478 Interdomain contacts; other site 886882009479 Cytokine receptor motif; other site 886882009480 acetyl-CoA synthetase; Provisional; Region: PRK04319 886882009481 Domain of unknown function (DUF3448); Region: DUF3448; pfam11930 886882009482 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 886882009483 acyl-activating enzyme (AAE) consensus motif; other site 886882009484 AMP binding site [chemical binding]; other site 886882009485 active site 886882009486 CoA binding site [chemical binding]; other site 886882009487 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882009488 Coenzyme A binding pocket [chemical binding]; other site 886882009489 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 886882009490 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 886882009491 catabolite control protein A; Region: ccpA; TIGR01481 886882009492 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882009493 DNA binding site [nucleotide binding] 886882009494 domain linker motif; other site 886882009495 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 886882009496 dimerization interface [polypeptide binding]; other site 886882009497 effector binding site; other site 886882009498 Protein of unknown function (DUF2847); Region: DUF2847; cl17683 886882009499 intracellular protease, PfpI family; Region: PfpI; TIGR01382 886882009500 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 886882009501 proposed catalytic triad [active] 886882009502 conserved cys residue [active] 886882009503 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 886882009504 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 886882009505 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 886882009506 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 886882009507 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 886882009508 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882009509 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 886882009510 active site turn [active] 886882009511 phosphorylation site [posttranslational modification] 886882009512 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 886882009513 HPr interaction site; other site 886882009514 glycerol kinase (GK) interaction site [polypeptide binding]; other site 886882009515 active site 886882009516 phosphorylation site [posttranslational modification] 886882009517 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 886882009518 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 886882009519 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 886882009520 hinge; other site 886882009521 active site 886882009522 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 886882009523 active site residue [active] 886882009524 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 886882009525 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 886882009526 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 886882009527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4493 886882009528 Protein of unknown function (DUF1054); Region: DUF1054; pfam06335 886882009529 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882009530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882009531 putative substrate translocation pore; other site 886882009532 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 886882009533 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 886882009534 homodimer interface [polypeptide binding]; other site 886882009535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882009536 catalytic residue [active] 886882009537 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 886882009538 Protein of unknown function (DUF1292); Region: DUF1292; pfam06949 886882009539 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 886882009540 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 886882009541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 886882009542 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 886882009543 iron-sulfur cluster [ion binding]; other site 886882009544 [2Fe-2S] cluster binding site [ion binding]; other site 886882009545 NAD(P)H-nitrite reductase [Energy production and conversion]; Region: NirB; COG1251 886882009546 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882009547 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 886882009548 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 886882009549 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 886882009550 ANTAR domain; Region: ANTAR; pfam03861 886882009551 Anthranilate phosphoribosyltransferase [Amino acid transport and metabolism]; Region: TrpD; COG0547 886882009552 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 886882009553 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 886882009554 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 886882009555 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 886882009556 molybdopterin cofactor binding site; other site 886882009557 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 886882009558 molybdopterin cofactor binding site; other site 886882009559 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 886882009560 Domain of unknown function (DUF4313); Region: DUF4313; pfam14190 886882009561 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882009562 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 886882009563 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 886882009564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882009565 putative substrate translocation pore; other site 886882009566 malate dehydrogenase; Provisional; Region: PRK13529 886882009567 Malic enzyme, N-terminal domain; Region: malic; pfam00390 886882009568 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 886882009569 NAD(P) binding site [chemical binding]; other site 886882009570 Membrane transport protein; Region: Mem_trans; cl09117 886882009571 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882009572 dimerization interface [polypeptide binding]; other site 886882009573 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882009574 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882009575 dimer interface [polypeptide binding]; other site 886882009576 putative CheW interface [polypeptide binding]; other site 886882009577 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 886882009578 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 886882009579 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 886882009580 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 886882009581 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 886882009582 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882009583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882009584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 886882009585 ABC-ATPase subunit interface; other site 886882009586 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882009587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882009588 dimer interface [polypeptide binding]; other site 886882009589 conserved gate region; other site 886882009590 putative PBP binding loops; other site 886882009591 ABC-ATPase subunit interface; other site 886882009592 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882009593 Response regulator receiver domain; Region: Response_reg; pfam00072 886882009594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882009595 active site 886882009596 phosphorylation site [posttranslational modification] 886882009597 intermolecular recognition site; other site 886882009598 dimerization interface [polypeptide binding]; other site 886882009599 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882009600 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882009601 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882009602 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882009603 dimerization interface [polypeptide binding]; other site 886882009604 Histidine kinase; Region: His_kinase; pfam06580 886882009605 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882009606 ATP binding site [chemical binding]; other site 886882009607 Mg2+ binding site [ion binding]; other site 886882009608 G-X-G motif; other site 886882009609 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 886882009610 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 886882009611 ligand binding site [chemical binding]; other site 886882009612 active site 886882009613 UGI interface [polypeptide binding]; other site 886882009614 catalytic site [active] 886882009615 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 886882009616 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 886882009617 dimer interface [polypeptide binding]; other site 886882009618 anticodon binding site; other site 886882009619 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 886882009620 homodimer interface [polypeptide binding]; other site 886882009621 motif 1; other site 886882009622 active site 886882009623 motif 2; other site 886882009624 GAD domain; Region: GAD; pfam02938 886882009625 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 886882009626 active site 886882009627 motif 3; other site 886882009628 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 886882009629 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 886882009630 2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742 886882009631 FMN binding site [chemical binding]; other site 886882009632 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 886882009633 substrate binding site [chemical binding]; other site 886882009634 putative catalytic residue [active] 886882009635 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 886882009636 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 886882009637 hypothetical protein; Provisional; Region: PRK06194 886882009638 classical (c) SDRs; Region: SDR_c; cd05233 886882009639 NAD(P) binding site [chemical binding]; other site 886882009640 active site 886882009641 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 886882009642 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 886882009643 putative NADP binding site [chemical binding]; other site 886882009644 active site 886882009645 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882009646 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 886882009647 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 886882009648 active site 886882009649 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 886882009650 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 886882009651 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 886882009652 putative NADP binding site [chemical binding]; other site 886882009653 active site 886882009654 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882009655 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 886882009656 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882009657 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 886882009658 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 886882009659 active site 886882009660 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 886882009661 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 886882009662 substrate binding site [chemical binding]; other site 886882009663 oxyanion hole (OAH) forming residues; other site 886882009664 trimer interface [polypeptide binding]; other site 886882009665 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 886882009666 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 886882009667 active site 886882009668 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 886882009669 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 886882009670 putative NADP binding site [chemical binding]; other site 886882009671 KR domain; Region: KR; pfam08659 886882009672 active site 886882009673 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882009674 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 886882009675 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 886882009676 active site 886882009677 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 886882009678 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 886882009679 putative NADP binding site [chemical binding]; other site 886882009680 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 886882009681 active site 886882009682 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882009683 S-adenosylmethionine binding site [chemical binding]; other site 886882009684 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 886882009685 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 886882009686 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 886882009687 active site 886882009688 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882009689 S-adenosylmethionine binding site [chemical binding]; other site 886882009690 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 886882009691 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 886882009692 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 886882009693 active site 886882009694 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 886882009695 putative NADP binding site [chemical binding]; other site 886882009696 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 886882009697 active site 886882009698 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 886882009699 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 886882009700 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 886882009701 active site 886882009702 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 886882009703 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 886882009704 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 886882009705 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 886882009706 active site 886882009707 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 886882009708 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 886882009709 putative NADP binding site [chemical binding]; other site 886882009710 KR domain; Region: KR; pfam08659 886882009711 active site 886882009712 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882009713 Polyketide synthase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3321 886882009714 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 886882009715 active site 886882009716 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 886882009717 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 886882009718 KR domain; Region: KR; pfam08659 886882009719 putative NADP binding site [chemical binding]; other site 886882009720 active site 886882009721 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 886882009722 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 886882009723 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 886882009724 active site 886882009725 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882009726 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 886882009727 acyl-CoA synthetase; Validated; Region: PRK05850 886882009728 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 886882009729 acyl-activating enzyme (AAE) consensus motif; other site 886882009730 active site 886882009731 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882009732 Condensation domain; Region: Condensation; pfam00668 886882009733 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882009734 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882009735 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 886882009736 acyl-activating enzyme (AAE) consensus motif; other site 886882009737 AMP binding site [chemical binding]; other site 886882009738 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882009739 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 886882009740 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 886882009741 active site 886882009742 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 886882009743 putative NADP binding site [chemical binding]; other site 886882009744 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 886882009745 active site 886882009746 Phosphopantetheine attachment site; Region: PKS_PP; smart00823 886882009747 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 886882009748 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 886882009749 active site 886882009750 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882009751 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 886882009752 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 886882009753 substrate binding site [chemical binding]; other site 886882009754 oxyanion hole (OAH) forming residues; other site 886882009755 trimer interface [polypeptide binding]; other site 886882009756 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 886882009757 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 886882009758 substrate binding site [chemical binding]; other site 886882009759 oxyanion hole (OAH) forming residues; other site 886882009760 trimer interface [polypeptide binding]; other site 886882009761 3-hydroxy-3-methylglutaryl CoA synthase [Lipid metabolism]; Region: PksG; COG3425 886882009762 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 886882009763 dimer interface [polypeptide binding]; other site 886882009764 active site 886882009765 polyketide beta-ketoacyl:acyl carrier protein synthase; Validated; Region: PRK07103 886882009766 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 886882009767 dimer interface [polypeptide binding]; other site 886882009768 active site 886882009769 acyl carrier protein; Validated; Region: PRK07117 886882009770 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 886882009771 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 886882009772 Transcription antiterminator [Transcription]; Region: NusG; COG0250 886882009773 N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cd08000 886882009774 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 886882009775 heterodimer interface [polypeptide binding]; other site 886882009776 homodimer interface [polypeptide binding]; other site 886882009777 Uncharacterized conserved protein (DUF2217); Region: DUF2217; pfam10265 886882009778 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 886882009779 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 886882009780 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 886882009781 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 886882009782 dimer interface [polypeptide binding]; other site 886882009783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882009784 catalytic residue [active] 886882009785 YolD-like protein; Region: YolD; pfam08863 886882009786 The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia. This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775 886882009787 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 886882009788 hypothetical protein; Provisional; Region: PRK02237 886882009789 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 886882009790 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 886882009791 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 886882009792 dimer interface [polypeptide binding]; other site 886882009793 active site 886882009794 metal binding site [ion binding]; metal-binding site 886882009795 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 886882009796 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 886882009797 Coenzyme A binding pocket [chemical binding]; other site 886882009798 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 886882009799 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 886882009800 dimer interface [polypeptide binding]; other site 886882009801 active site 886882009802 CoA binding pocket [chemical binding]; other site 886882009803 spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869 886882009804 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 886882009805 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 886882009806 Cupin; Region: Cupin_1; smart00835 886882009807 Sm and related proteins; Region: Sm_like; cl00259 886882009808 Sm1 motif; other site 886882009809 hexamer interface [polypeptide binding]; other site 886882009810 RNA binding site [nucleotide binding]; other site 886882009811 Protein of unknown function (DUF2642); Region: DUF2642; pfam10842 886882009812 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882009813 AMIN domain; Region: AMIN; pfam11741 886882009814 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 886882009815 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 886882009816 active site 886882009817 Predicted membrane protein [Function unknown]; Region: COG2855 886882009818 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882009819 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882009820 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 886882009821 putative dimerization interface [polypeptide binding]; other site 886882009822 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 886882009823 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 886882009824 inhibitor binding site; inhibition site 886882009825 active site 886882009826 Pectinesterase; Region: Pectinesterase; pfam01095 886882009827 putative pectinesterase; Region: PLN02432; cl01911 886882009828 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 886882009829 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 886882009830 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 886882009831 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 886882009832 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882009833 Predicted integral membrane protein [Function unknown]; Region: COG5578 886882009834 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882009835 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882009836 dimer interface [polypeptide binding]; other site 886882009837 conserved gate region; other site 886882009838 ABC-ATPase subunit interface; other site 886882009839 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882009840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882009841 dimer interface [polypeptide binding]; other site 886882009842 conserved gate region; other site 886882009843 putative PBP binding loops; other site 886882009844 ABC-ATPase subunit interface; other site 886882009845 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882009846 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882009847 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882009848 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 886882009849 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 886882009850 Rhamnogalacturan_acetylesterase_like subgroup of SGNH-hydrolases. Rhamnogalacturan acetylesterase removes acetyl esters from rhamnogalacturonan substrates, and renders them susceptible to degradation by rhamnogalacturonases. Rhamnogalacturonans are...; Region: Rhamnogalacturan_acetylesterase_like; cd01821 886882009851 active site 886882009852 catalytic triad [active] 886882009853 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 886882009854 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882009855 Radical SAM superfamily; Region: Radical_SAM; pfam04055 886882009856 FeS/SAM binding site; other site 886882009857 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 886882009858 Caspase domain; Region: Peptidase_C14; pfam00656 886882009859 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882009860 non-specific DNA binding site [nucleotide binding]; other site 886882009861 salt bridge; other site 886882009862 sequence-specific DNA binding site [nucleotide binding]; other site 886882009863 Lecithin:cholesterol acyltransferase; Region: LACT; pfam02450 886882009864 PGAP1-like protein; Region: PGAP1; pfam07819 886882009865 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539 886882009866 Holin family; Region: Phage_holin_4; pfam05105 886882009867 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 886882009868 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 886882009869 Uncharacterized protein conserved in bacteria (DUF2313); Region: DUF2313; cl01542 886882009870 Baseplate J-like protein; Region: Baseplate_J; pfam04865 886882009871 Protein of unknown function (DUF2634); Region: DUF2634; pfam10934 886882009872 Phage-related minor tail protein [Function unknown]; Region: COG5280 886882009873 Protein of unknown function (DUF2001); Region: DUF2001; pfam09393 886882009874 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 886882009875 Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049 886882009876 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 886882009877 Phage major capsid protein, P2 family; Region: Phage_cap_P2; cl04947 886882009878 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 886882009879 Phage-related protein [Function unknown]; Region: COG4695; cl01923 886882009880 large terminase protein; Provisional; Region: 17; PHA02533 886882009881 Uncharacterized conserved protein [Function unknown]; Region: COG5484 886882009882 Phage terminase small subunit; Region: Phage_terminase; pfam10668 886882009883 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 886882009884 ParB-like nuclease domain; Region: ParB; smart00470 886882009885 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 886882009886 DNA methylase; Region: N6_N4_Mtase; pfam01555 886882009887 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 886882009888 metal binding triad [ion binding]; metal-binding site 886882009889 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 886882009890 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08979 886882009891 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 886882009892 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 886882009893 Walker A motif; other site 886882009894 ATP binding site [chemical binding]; other site 886882009895 Walker B motif; other site 886882009896 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 886882009897 Bacteriophage replication protein O; Region: Phage_rep_O; cl04545 886882009898 RecT family; Region: RecT; cl04285 886882009899 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 886882009900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882009901 non-specific DNA binding site [nucleotide binding]; other site 886882009902 salt bridge; other site 886882009903 sequence-specific DNA binding site [nucleotide binding]; other site 886882009904 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 886882009905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882009906 non-specific DNA binding site [nucleotide binding]; other site 886882009907 salt bridge; other site 886882009908 sequence-specific DNA binding site [nucleotide binding]; other site 886882009909 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 886882009910 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882009911 non-specific DNA binding site [nucleotide binding]; other site 886882009912 salt bridge; other site 886882009913 sequence-specific DNA binding site [nucleotide binding]; other site 886882009914 Domain of unknown function (DUF955); Region: DUF955; pfam06114 886882009915 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 886882009916 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 886882009917 Int/Topo IB signature motif; other site 886882009918 HNH endonuclease; Region: HNH_2; pfam13391 886882009919 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 886882009920 active site 886882009921 8-oxo-dGMP binding site [chemical binding]; other site 886882009922 nudix motif; other site 886882009923 metal binding site [ion binding]; metal-binding site 886882009924 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 886882009925 active site 886882009926 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 886882009927 active site 886882009928 dimer interface [polypeptide binding]; other site 886882009929 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 886882009930 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 886882009931 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 886882009932 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 886882009933 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 886882009934 ATP-grasp domain; Region: ATP-grasp_4; cl17255 886882009935 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 886882009936 IMP binding site; other site 886882009937 dimer interface [polypeptide binding]; other site 886882009938 interdomain contacts; other site 886882009939 partial ornithine binding site; other site 886882009940 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 886882009941 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 886882009942 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 886882009943 catalytic site [active] 886882009944 subunit interface [polypeptide binding]; other site 886882009945 dihydroorotase; Validated; Region: pyrC; PRK09357 886882009946 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 886882009947 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 886882009948 active site 886882009949 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 886882009950 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 886882009951 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 886882009952 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 886882009953 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 886882009954 active site 886882009955 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 886882009956 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 886882009957 RNA binding surface [nucleotide binding]; other site 886882009958 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 886882009959 active site 886882009960 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 886882009961 lipoprotein signal peptidase; Provisional; Region: PRK14787 886882009962 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 886882009963 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 886882009964 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 886882009965 active site 886882009966 HIGH motif; other site 886882009967 nucleotide binding site [chemical binding]; other site 886882009968 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 886882009969 active site 886882009970 KMSKS motif; other site 886882009971 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 886882009972 tRNA binding surface [nucleotide binding]; other site 886882009973 anticodon binding site; other site 886882009974 DivIVA protein; Region: DivIVA; pfam05103 886882009975 DivIVA domain; Region: DivI1A_domain; TIGR03544 886882009976 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 886882009977 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 886882009978 RNA binding surface [nucleotide binding]; other site 886882009979 YGGT family; Region: YGGT; pfam02325 886882009980 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 886882009981 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 886882009982 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 886882009983 catalytic residue [active] 886882009984 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 886882009985 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 886882009986 sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888 886882009987 sporulation sigma factor SigG; Reviewed; Region: PRK08215 886882009988 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882009989 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 886882009990 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882009991 DNA binding residues [nucleotide binding] 886882009992 sporulation sigma factor SigE; Reviewed; Region: PRK08301 886882009993 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882009994 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882009995 DNA binding residues [nucleotide binding] 886882009996 Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419 886882009997 sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854 886882009998 cell division protein FtsZ; Validated; Region: PRK09330 886882009999 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 886882010000 nucleotide binding site [chemical binding]; other site 886882010001 SulA interaction site; other site 886882010002 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 886882010003 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 886882010004 nucleotide binding site [chemical binding]; other site 886882010005 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 886882010006 Cell division protein FtsA; Region: FtsA; pfam14450 886882010007 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 886882010008 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 886882010009 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 886882010010 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 886882010011 hinge; other site 886882010012 active site 886882010013 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 886882010014 FAD binding domain; Region: FAD_binding_4; pfam01565 886882010015 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 886882010016 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 886882010017 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 886882010018 active site 886882010019 homodimer interface [polypeptide binding]; other site 886882010020 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 886882010021 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 886882010022 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 886882010023 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 886882010024 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 886882010025 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 886882010026 Mg++ binding site [ion binding]; other site 886882010027 putative catalytic motif [active] 886882010028 putative substrate binding site [chemical binding]; other site 886882010029 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 886882010030 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 886882010031 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 886882010032 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 886882010033 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 886882010034 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 886882010035 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 886882010036 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 886882010037 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 886882010038 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 886882010039 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 886882010040 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573 886882010041 stage V sporulation protein D; Region: spoVD_pbp; TIGR02214 886882010042 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 886882010043 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 886882010044 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 886882010045 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 886882010046 MraW methylase family; Region: Methyltransf_5; pfam01795 886882010047 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 886882010048 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 886882010049 MraZ protein; Region: MraZ; pfam02381 886882010050 MraZ protein; Region: MraZ; pfam02381 886882010051 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 886882010052 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 886882010053 homotetramer interface [polypeptide binding]; other site 886882010054 ligand binding site [chemical binding]; other site 886882010055 catalytic site [active] 886882010056 NAD binding site [chemical binding]; other site 886882010057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365 886882010058 bacillithiol biosynthesis cysteine-adding enzyme BshC; Region: thiol_BshC; TIGR03998 886882010059 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 886882010060 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 886882010061 Walker A/P-loop; other site 886882010062 ATP binding site [chemical binding]; other site 886882010063 Q-loop/lid; other site 886882010064 ABC transporter signature motif; other site 886882010065 Walker B; other site 886882010066 D-loop; other site 886882010067 H-loop/switch region; other site 886882010068 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 886882010069 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 886882010070 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 886882010071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882010072 dimer interface [polypeptide binding]; other site 886882010073 conserved gate region; other site 886882010074 putative PBP binding loops; other site 886882010075 ABC-ATPase subunit interface; other site 886882010076 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 886882010077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882010078 dimer interface [polypeptide binding]; other site 886882010079 conserved gate region; other site 886882010080 putative PBP binding loops; other site 886882010081 ABC-ATPase subunit interface; other site 886882010082 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 886882010083 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 886882010084 peptide binding site [polypeptide binding]; other site 886882010085 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 886882010086 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 886882010087 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 886882010088 putative spore coat protein regulator protein YlbO; Provisional; Region: PRK13923 886882010089 transcription factor, RsfA family; Region: DNA_bind_RsfA; TIGR02894 886882010090 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 886882010091 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 886882010092 putative active site [active] 886882010093 PhoH-like protein; Region: PhoH; pfam02562 886882010094 Transcriptional regulator [Transcription]; Region: LytR; COG1316 886882010095 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 886882010096 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 886882010097 putative GEF interaction site [polypeptide binding]; other site 886882010098 G1 box; other site 886882010099 GTP/Mg2+ binding site [chemical binding]; other site 886882010100 Switch I region; other site 886882010101 G2 box; other site 886882010102 G3 box; other site 886882010103 Switch II region; other site 886882010104 G4 box; other site 886882010105 G5 box; other site 886882010106 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 886882010107 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 886882010108 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 886882010109 integral membrane protein, YjbE family; Region: R_switched_YjbE; TIGR03717 886882010110 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 886882010111 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 886882010112 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 886882010113 Ligand Binding Site [chemical binding]; other site 886882010114 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 886882010115 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 886882010116 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 886882010117 catalytic residue [active] 886882010118 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 886882010119 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 886882010120 N-acetyl-D-glucosamine binding site [chemical binding]; other site 886882010121 catalytic residue [active] 886882010122 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 886882010123 Protein of unknown function (DUF3907); Region: DUF3907; pfam13047 886882010124 Peptidase S8 family domain in Thermitase-like proteins; Region: Peptidases_S8_Thermitase_like; cd07484 886882010125 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 886882010126 active site 886882010127 catalytic triad [active] 886882010128 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 886882010129 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882010130 DNA-binding site [nucleotide binding]; DNA binding site 886882010131 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882010132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882010133 homodimer interface [polypeptide binding]; other site 886882010134 catalytic residue [active] 886882010135 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 886882010136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882010137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882010138 homodimer interface [polypeptide binding]; other site 886882010139 catalytic residue [active] 886882010140 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 886882010141 Uncharacterized conserved protein [Function unknown]; Region: COG0327 886882010142 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 886882010143 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 886882010144 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 886882010145 Uncharacterized conserved protein [Function unknown]; Region: COG0327 886882010146 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 886882010147 Family of unknown function (DUF633); Region: DUF633; pfam04816 886882010148 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 886882010149 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 886882010150 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 886882010151 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882010152 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 886882010153 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882010154 DNA binding residues [nucleotide binding] 886882010155 DNA primase; Validated; Region: dnaG; PRK05667 886882010156 CHC2 zinc finger; Region: zf-CHC2; pfam01807 886882010157 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 886882010158 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 886882010159 active site 886882010160 metal binding site [ion binding]; metal-binding site 886882010161 interdomain interaction site; other site 886882010162 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 886882010163 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; cl00727 886882010164 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 886882010165 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 886882010166 dimer interface [polypeptide binding]; other site 886882010167 motif 1; other site 886882010168 active site 886882010169 motif 2; other site 886882010170 motif 3; other site 886882010171 DNA repair protein RecO; Region: reco; TIGR00613 886882010172 Recombination protein O N terminal; Region: RecO_N; pfam11967 886882010173 Recombination protein O C terminal; Region: RecO_C; pfam02565 886882010174 YqzL-like protein; Region: YqzL; pfam14006 886882010175 GTPase Era; Reviewed; Region: era; PRK00089 886882010176 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 886882010177 G1 box; other site 886882010178 GTP/Mg2+ binding site [chemical binding]; other site 886882010179 Switch I region; other site 886882010180 G2 box; other site 886882010181 Switch II region; other site 886882010182 G3 box; other site 886882010183 G4 box; other site 886882010184 G5 box; other site 886882010185 KH domain; Region: KH_2; pfam07650 886882010186 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 886882010187 metal-binding heat shock protein; Provisional; Region: PRK00016 886882010188 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 886882010189 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882010190 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882010191 Zn2+ binding site [ion binding]; other site 886882010192 Mg2+ binding site [ion binding]; other site 886882010193 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 886882010194 PhoH-like protein; Region: PhoH; pfam02562 886882010195 sporulation protein YqfD; Region: spore_yqfD; TIGR02876 886882010196 Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898 886882010197 YabP family; Region: YabP; cl06766 886882010198 amino acid transporter; Region: 2A0306; TIGR00909 886882010199 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 886882010200 hypothetical protein; Provisional; Region: PRK13665 886882010201 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 886882010202 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 886882010203 dimer interface [polypeptide binding]; other site 886882010204 active site residues [active] 886882010205 NfeD-like C-terminal, partner-binding; Region: NfeD; cl00686 886882010206 Yqey-like protein; Region: YqeY; pfam09424 886882010207 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 886882010208 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 886882010209 nucleotide binding site/active site [active] 886882010210 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 886882010211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882010212 DNA-binding site [nucleotide binding]; DNA binding site 886882010213 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882010214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882010215 homodimer interface [polypeptide binding]; other site 886882010216 catalytic residue [active] 886882010217 ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279 886882010218 AAA domain; Region: AAA_23; pfam13476 886882010219 Walker A/P-loop; other site 886882010220 ATP binding site [chemical binding]; other site 886882010221 Q-loop/lid; other site 886882010222 ABC transporter signature motif; other site 886882010223 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 886882010224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882010225 ABC transporter signature motif; other site 886882010226 Walker B; other site 886882010227 D-loop; other site 886882010228 H-loop/switch region; other site 886882010229 exonuclease subunit SbcD; Provisional; Region: PRK10966 886882010230 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 886882010231 active site 886882010232 metal binding site [ion binding]; metal-binding site 886882010233 DNA binding site [nucleotide binding] 886882010234 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 886882010235 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 886882010236 Part of AAA domain; Region: AAA_19; pfam13245 886882010237 Vi polysaccharide biosynthesis protein TviA; Provisional; Region: PRK15183 886882010238 Family description; Region: UvrD_C_2; pfam13538 886882010239 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 886882010240 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 886882010241 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 886882010242 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 886882010243 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 886882010244 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 886882010245 putative RNA binding site [nucleotide binding]; other site 886882010246 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882010247 S-adenosylmethionine binding site [chemical binding]; other site 886882010248 Na/Pi-cotransporter; Region: NaPi_cotrn_rel; TIGR00704 886882010249 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 886882010250 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 886882010251 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 886882010252 active site 886882010253 Ap6A binding site [chemical binding]; other site 886882010254 nudix motif; other site 886882010255 metal binding site [ion binding]; metal-binding site 886882010256 2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621 886882010257 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 886882010258 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882010259 FeS/SAM binding site; other site 886882010260 TRAM domain; Region: TRAM; cl01282 886882010261 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 886882010262 RNA methyltransferase, RsmE family; Region: TIGR00046 886882010263 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158 886882010264 Peptidase family M50; Region: Peptidase_M50; pfam02163 886882010265 active site 886882010266 putative substrate binding region [chemical binding]; other site 886882010267 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 886882010268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882010269 S-adenosylmethionine binding site [chemical binding]; other site 886882010270 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 886882010271 Malic enzyme, N-terminal domain; Region: malic; pfam00390 886882010272 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 886882010273 putative NAD(P) binding site [chemical binding]; other site 886882010274 2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390 886882010275 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 886882010276 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882010277 active site 886882010278 phosphorylation site [posttranslational modification] 886882010279 intermolecular recognition site; other site 886882010280 dimerization interface [polypeptide binding]; other site 886882010281 sensory histidine kinase DcuS; Provisional; Region: PRK11086 886882010282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882010283 ATP binding site [chemical binding]; other site 886882010284 Mg2+ binding site [ion binding]; other site 886882010285 G-X-G motif; other site 886882010286 chaperone protein DnaJ; Provisional; Region: PRK14280 886882010287 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 886882010288 HSP70 interaction site [polypeptide binding]; other site 886882010289 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 886882010290 substrate binding site [polypeptide binding]; other site 886882010291 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 886882010292 Zn binding sites [ion binding]; other site 886882010293 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 886882010294 dimer interface [polypeptide binding]; other site 886882010295 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 886882010296 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 886882010297 nucleotide binding site [chemical binding]; other site 886882010298 NEF interaction site [polypeptide binding]; other site 886882010299 SBD interface [polypeptide binding]; other site 886882010300 GrpE; Region: GrpE; pfam01025 886882010301 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 886882010302 dimer interface [polypeptide binding]; other site 886882010303 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 886882010304 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 886882010305 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 886882010306 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882010307 Coenzyme A binding pocket [chemical binding]; other site 886882010308 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 886882010309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882010310 FeS/SAM binding site; other site 886882010311 HemN C-terminal domain; Region: HemN_C; pfam06969 886882010312 GTP-binding protein LepA; Provisional; Region: PRK05433 886882010313 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 886882010314 G1 box; other site 886882010315 putative GEF interaction site [polypeptide binding]; other site 886882010316 GTP/Mg2+ binding site [chemical binding]; other site 886882010317 Switch I region; other site 886882010318 G2 box; other site 886882010319 G3 box; other site 886882010320 Switch II region; other site 886882010321 G4 box; other site 886882010322 G5 box; other site 886882010323 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 886882010324 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 886882010325 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 886882010326 Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454 886882010327 stage II sporulation protein P; Region: spore_II_P; TIGR02867 886882010328 germination protease; Provisional; Region: PRK02858 886882010329 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 886882010330 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 886882010331 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 886882010332 Putative zinc-finger; Region: zf-HC2; pfam13490 886882010333 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 886882010334 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882010335 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882010336 DNA binding residues [nucleotide binding] 886882010337 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 886882010338 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 886882010339 Competence protein; Region: Competence; pfam03772 886882010340 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 886882010341 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 886882010342 catalytic motif [active] 886882010343 Zn binding site [ion binding]; other site 886882010344 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 886882010345 Helix-hairpin-helix motif; Region: HHH; pfam00633 886882010346 late competence protein ComER; Validated; Region: PRK07680 886882010347 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 886882010348 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 886882010349 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 886882010350 HIGH motif; other site 886882010351 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 886882010352 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 886882010353 active site 886882010354 KMSKS motif; other site 886882010355 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 886882010356 tRNA binding surface [nucleotide binding]; other site 886882010357 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cl01268 886882010358 trimer interface [polypeptide binding]; other site 886882010359 putative substrate binding pocket [chemical binding]; other site 886882010360 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 886882010361 active site 1 [active] 886882010362 dimer interface [polypeptide binding]; other site 886882010363 hexamer interface [polypeptide binding]; other site 886882010364 active site 2 [active] 886882010365 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 886882010366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882010367 S-adenosylmethionine binding site [chemical binding]; other site 886882010368 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 886882010369 S1 domain; Region: S1_2; pfam13509 886882010370 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 886882010371 RNA binding site [nucleotide binding]; other site 886882010372 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 886882010373 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882010374 Zn2+ binding site [ion binding]; other site 886882010375 Mg2+ binding site [ion binding]; other site 886882010376 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 886882010377 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 886882010378 active site 886882010379 (T/H)XGH motif; other site 886882010380 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 886882010381 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 886882010382 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 886882010383 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 886882010384 shikimate binding site; other site 886882010385 NAD(P) binding site [chemical binding]; other site 886882010386 GTPase YqeH; Provisional; Region: PRK13796 886882010387 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 886882010388 GTP/Mg2+ binding site [chemical binding]; other site 886882010389 G4 box; other site 886882010390 G5 box; other site 886882010391 G1 box; other site 886882010392 Switch I region; other site 886882010393 G2 box; other site 886882010394 G3 box; other site 886882010395 Switch II region; other site 886882010396 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 886882010397 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882010398 active site 886882010399 motif I; other site 886882010400 motif II; other site 886882010401 The Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT; cl04176 886882010402 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 886882010403 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 886882010404 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 886882010405 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 886882010406 Protein of unknown function DUF58; Region: DUF58; pfam01882 886882010407 MoxR-like ATPases [General function prediction only]; Region: COG0714 886882010408 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882010409 Walker A motif; other site 886882010410 ATP binding site [chemical binding]; other site 886882010411 Walker B motif; other site 886882010412 arginine finger; other site 886882010413 stage V sporulation protein AE; Region: spore_V_AE; TIGR02839 886882010414 stage V sporulation protein AD; Validated; Region: PRK08304 886882010415 stage V sporulation protein AD; Provisional; Region: PRK12404 886882010416 SpoVA protein; Region: SpoVA; cl04298 886882010417 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 886882010418 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 886882010419 oligomer interface [polypeptide binding]; other site 886882010420 active site 886882010421 metal binding site [ion binding]; metal-binding site 886882010422 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 886882010423 Endoglucanase C-terminal domain/subunit and related proteins [Carbohydrate transport and metabolism]; Region: COG4305 886882010424 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 886882010425 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882010426 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882010427 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882010428 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882010429 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 886882010430 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882010431 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882010432 dimer interface [polypeptide binding]; other site 886882010433 conserved gate region; other site 886882010434 putative PBP binding loops; other site 886882010435 ABC-ATPase subunit interface; other site 886882010436 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882010437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882010438 dimer interface [polypeptide binding]; other site 886882010439 conserved gate region; other site 886882010440 ABC-ATPase subunit interface; other site 886882010441 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 886882010442 extended (e) SDRs; Region: SDR_e; cd08946 886882010443 NAD(P) binding site [chemical binding]; other site 886882010444 active site 886882010445 substrate binding site [chemical binding]; other site 886882010446 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 886882010447 EamA-like transporter family; Region: EamA; pfam00892 886882010448 EamA-like transporter family; Region: EamA; pfam00892 886882010449 Uncharacterized conserved protein [Function unknown]; Region: COG1434 886882010450 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 886882010451 putative active site [active] 886882010452 Uncharacterized conserved protein [Function unknown]; Region: COG1683 886882010453 sporulation sigma factor SigK; Reviewed; Region: PRK05803 886882010454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882010455 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882010456 DNA binding residues [nucleotide binding] 886882010457 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 886882010458 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882010459 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882010460 putative substrate translocation pore; other site 886882010461 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 886882010462 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 886882010463 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882010464 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882010465 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882010466 Interdomain contacts; other site 886882010467 Cytokine receptor motif; other site 886882010468 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882010469 Interdomain contacts; other site 886882010470 Cytokine receptor motif; other site 886882010471 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882010472 Interdomain contacts; other site 886882010473 Cytokine receptor motif; other site 886882010474 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882010475 Interdomain contacts; other site 886882010476 Cytokine receptor motif; other site 886882010477 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882010478 Interdomain contacts; other site 886882010479 Cytokine receptor motif; other site 886882010480 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882010481 Interdomain contacts; other site 886882010482 Cytokine receptor motif; other site 886882010483 S-layer homology domain; Region: SLH; pfam00395 886882010484 S-layer homology domain; Region: SLH; pfam00395 886882010485 S-layer homology domain; Region: SLH; pfam00395 886882010486 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 886882010487 AAA domain; Region: AAA_33; pfam13671 886882010488 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 886882010489 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 886882010490 Thg1 C terminal domain; Region: Thg1C; pfam14413 886882010491 Uncharacterized conserved protein [Function unknown]; Region: COG5609 886882010492 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 886882010493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882010494 dimer interface [polypeptide binding]; other site 886882010495 ABC-ATPase subunit interface; other site 886882010496 putative PBP binding loops; other site 886882010497 PBP superfamily domain; Region: PBP_like_2; cl17296 886882010498 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 886882010499 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 886882010500 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 886882010501 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 886882010502 ATP binding site [chemical binding]; other site 886882010503 substrate interface [chemical binding]; other site 886882010504 Ubiquitin-like proteins; Region: UBQ; cl00155 886882010505 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 886882010506 MoaE homodimer interface [polypeptide binding]; other site 886882010507 MoaD interaction [polypeptide binding]; other site 886882010508 active site residues [active] 886882010509 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 886882010510 MoaE interaction surface [polypeptide binding]; other site 886882010511 MoeB interaction surface [polypeptide binding]; other site 886882010512 thiocarboxylated glycine; other site 886882010513 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 886882010514 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 886882010515 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882010516 FeS/SAM binding site; other site 886882010517 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 886882010518 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 886882010519 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 886882010520 catalytic loop [active] 886882010521 iron binding site [ion binding]; other site 886882010522 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 886882010523 4Fe-4S binding domain; Region: Fer4; pfam00037 886882010524 4Fe-4S binding domain; Region: Fer4; pfam00037 886882010525 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 886882010526 [4Fe-4S] binding site [ion binding]; other site 886882010527 molybdopterin cofactor binding site; other site 886882010528 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 886882010529 molybdopterin cofactor binding site; other site 886882010530 Uncharacterized conserved protein [Function unknown]; Region: COG2427 886882010531 2-keto-3-deoxygluconate permease; Region: KdgT; cl14653 886882010532 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 886882010533 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882010534 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882010535 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882010536 dimerization interface [polypeptide binding]; other site 886882010537 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882010538 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882010539 dimer interface [polypeptide binding]; other site 886882010540 putative CheW interface [polypeptide binding]; other site 886882010541 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 886882010542 ligand binding site [chemical binding]; other site 886882010543 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 886882010544 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 886882010545 Cytochrome P450; Region: p450; pfam00067 886882010546 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 886882010547 Flavodoxin; Region: Flavodoxin_1; pfam00258 886882010548 These bifunctional proteins fuse N-terminal cytochrome p450 with a cytochrome p450 reductase (CYPOR). NADPH cytochrome p450 reductase serves as an electron donor in several oxygenase systems and is a component of nitric oxide synthases and methionine...; Region: bifunctional_CYPOR; cd06206 886882010549 FAD binding pocket [chemical binding]; other site 886882010550 FAD binding motif [chemical binding]; other site 886882010551 catalytic residues [active] 886882010552 NAD binding pocket [chemical binding]; other site 886882010553 phosphate binding motif [ion binding]; other site 886882010554 beta-alpha-beta structure motif; other site 886882010555 Restriction endonuclease; Region: Mrr_cat; pfam04471 886882010556 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 886882010557 Aspartase; Region: Aspartase; cd01357 886882010558 active sites [active] 886882010559 tetramer interface [polypeptide binding]; other site 886882010560 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 886882010561 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882010562 Coenzyme A binding pocket [chemical binding]; other site 886882010563 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 886882010564 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 886882010565 aminotransferase A; Validated; Region: PRK07683 886882010566 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882010567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882010568 homodimer interface [polypeptide binding]; other site 886882010569 catalytic residue [active] 886882010570 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 886882010571 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882010572 H-loop/switch region; other site 886882010573 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 886882010574 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 886882010575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882010576 dimer interface [polypeptide binding]; other site 886882010577 conserved gate region; other site 886882010578 putative PBP binding loops; other site 886882010579 ABC-ATPase subunit interface; other site 886882010580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882010581 dimer interface [polypeptide binding]; other site 886882010582 conserved gate region; other site 886882010583 putative PBP binding loops; other site 886882010584 ABC-ATPase subunit interface; other site 886882010585 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 886882010586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882010587 Walker A/P-loop; other site 886882010588 ATP binding site [chemical binding]; other site 886882010589 Q-loop/lid; other site 886882010590 ABC transporter signature motif; other site 886882010591 Walker B; other site 886882010592 D-loop; other site 886882010593 H-loop/switch region; other site 886882010594 TOBE domain; Region: TOBE_2; pfam08402 886882010595 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 886882010596 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 886882010597 metal binding site [ion binding]; metal-binding site 886882010598 putative dimer interface [polypeptide binding]; other site 886882010599 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 886882010600 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 886882010601 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 886882010602 trimer interface [polypeptide binding]; other site 886882010603 active site 886882010604 substrate binding site [chemical binding]; other site 886882010605 CoA binding site [chemical binding]; other site 886882010606 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 886882010607 EamA-like transporter family; Region: EamA; pfam00892 886882010608 EamA-like transporter family; Region: EamA; pfam00892 886882010609 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 886882010610 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 886882010611 active site residue [active] 886882010612 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 886882010613 active site residue [active] 886882010614 Phosphotransferase enzyme family; Region: APH; pfam01636 886882010615 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 886882010616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 886882010617 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 886882010618 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 886882010619 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882010620 S-adenosylmethionine binding site [chemical binding]; other site 886882010621 Methyltransferase domain; Region: Methyltransf_23; pfam13489 886882010622 DinB superfamily; Region: DinB_2; pfam12867 886882010623 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 886882010624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882010625 S-adenosylmethionine binding site [chemical binding]; other site 886882010626 Phosphotransferase enzyme family; Region: APH; pfam01636 886882010627 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 886882010628 active site 886882010629 ATP binding site [chemical binding]; other site 886882010630 hypothetical protein; Provisional; Region: PRK13663 886882010631 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882010632 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 886882010633 Coenzyme A binding pocket [chemical binding]; other site 886882010634 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882010635 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 886882010636 Coenzyme A binding pocket [chemical binding]; other site 886882010637 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882010638 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882010639 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 886882010640 Short-chain dehydrogenase involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltE; COG3967 886882010641 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882010642 NAD(P) binding site [chemical binding]; other site 886882010643 active site 886882010644 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 886882010645 nudix motif; other site 886882010646 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882010647 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882010648 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 886882010649 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 886882010650 intersubunit interface [polypeptide binding]; other site 886882010651 Uncharacterized Fe-S protein [General function prediction only]; Region: FhuF; COG4114 886882010652 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 886882010653 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 886882010654 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 886882010655 siderophore binding site; other site 886882010656 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 886882010657 catalytic motif [active] 886882010658 Catalytic residue [active] 886882010659 Caspase domain; Region: Peptidase_C14; pfam00656 886882010660 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882010661 S-adenosylmethionine binding site [chemical binding]; other site 886882010662 Methyltransferase domain; Region: Methyltransf_31; pfam13847 886882010663 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882010664 S-adenosylmethionine binding site [chemical binding]; other site 886882010665 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 886882010666 non-specific DNA binding site [nucleotide binding]; other site 886882010667 salt bridge; other site 886882010668 sequence-specific DNA binding site [nucleotide binding]; other site 886882010669 Protein of unknown function (DUF3782); Region: DUF3782; pfam12644 886882010670 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 886882010671 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 886882010672 DNA binding site [nucleotide binding] 886882010673 Int/Topo IB signature motif; other site 886882010674 active site 886882010675 Cache domain; Region: Cache_1; pfam02743 886882010676 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882010677 dimerization interface [polypeptide binding]; other site 886882010678 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882010679 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882010680 dimer interface [polypeptide binding]; other site 886882010681 putative CheW interface [polypeptide binding]; other site 886882010682 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 886882010683 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 886882010684 substrate binding pocket [chemical binding]; other site 886882010685 chain length determination region; other site 886882010686 substrate-Mg2+ binding site; other site 886882010687 catalytic residues [active] 886882010688 aspartate-rich region 1; other site 886882010689 active site lid residues [active] 886882010690 aspartate-rich region 2; other site 886882010691 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 886882010692 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 886882010693 putative metal binding site [ion binding]; other site 886882010694 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 886882010695 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 886882010696 Predicted esterase of the alpha/beta hydrolase fold [General function prediction only]; Region: COG3545 886882010697 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 886882010698 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 886882010699 Protein of unknown function DUF2625; Region: DUF2625; cl08177 886882010700 Phosphotransferase enzyme family; Region: APH; pfam01636 886882010701 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 886882010702 active site 886882010703 ATP binding site [chemical binding]; other site 886882010704 substrate binding site [chemical binding]; other site 886882010705 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882010706 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882010707 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882010708 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882010709 putative substrate translocation pore; other site 886882010710 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 886882010711 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 886882010712 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 886882010713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882010714 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882010715 putative substrate translocation pore; other site 886882010716 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 886882010717 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882010718 dimerization interface [polypeptide binding]; other site 886882010719 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882010720 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882010721 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882010722 dimer interface [polypeptide binding]; other site 886882010723 putative CheW interface [polypeptide binding]; other site 886882010724 S-layer homology domain; Region: SLH; pfam00395 886882010725 S-layer homology domain; Region: SLH; pfam00395 886882010726 S-layer homology domain; Region: SLH; pfam00395 886882010727 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882010728 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882010729 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 886882010730 DinB superfamily; Region: DinB_2; pfam12867 886882010731 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 886882010732 putative active site [active] 886882010733 heme pocket [chemical binding]; other site 886882010734 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 886882010735 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 886882010736 metal binding site [ion binding]; metal-binding site 886882010737 active site 886882010738 I-site; other site 886882010739 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 886882010740 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882010741 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 886882010742 dimer interface [polypeptide binding]; other site 886882010743 putative CheW interface [polypeptide binding]; other site 886882010744 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 886882010745 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 886882010746 active site turn [active] 886882010747 phosphorylation site [posttranslational modification] 886882010748 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882010749 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 886882010750 HPr interaction site; other site 886882010751 glycerol kinase (GK) interaction site [polypeptide binding]; other site 886882010752 active site 886882010753 phosphorylation site [posttranslational modification] 886882010754 transcriptional antiterminator BglG; Provisional; Region: PRK09772 886882010755 CAT RNA binding domain; Region: CAT_RBD; pfam03123 886882010756 PRD domain; Region: PRD; pfam00874 886882010757 PRD domain; Region: PRD; pfam00874 886882010758 molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666 886882010759 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882010760 FeS/SAM binding site; other site 886882010761 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 886882010762 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 886882010763 MoaE interaction surface [polypeptide binding]; other site 886882010764 MoeB interaction surface [polypeptide binding]; other site 886882010765 thiocarboxylated glycine; other site 886882010766 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 886882010767 MoaE homodimer interface [polypeptide binding]; other site 886882010768 MoaD interaction [polypeptide binding]; other site 886882010769 active site residues [active] 886882010770 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 886882010771 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 886882010772 ATP binding site [chemical binding]; other site 886882010773 substrate interface [chemical binding]; other site 886882010774 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 886882010775 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882010776 putative substrate translocation pore; other site 886882010777 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 886882010778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882010779 active site 886882010780 phosphorylation site [posttranslational modification] 886882010781 intermolecular recognition site; other site 886882010782 dimerization interface [polypeptide binding]; other site 886882010783 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 886882010784 DNA binding residues [nucleotide binding] 886882010785 dimerization interface [polypeptide binding]; other site 886882010786 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 886882010787 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 886882010788 Histidine kinase; Region: HisKA_3; pfam07730 886882010789 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882010790 ATP binding site [chemical binding]; other site 886882010791 Mg2+ binding site [ion binding]; other site 886882010792 G-X-G motif; other site 886882010793 GAF domain; Region: GAF_3; pfam13492 886882010794 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 886882010795 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 886882010796 nitrate reductase, beta subunit; Region: narH; TIGR01660 886882010797 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 886882010798 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 886882010799 molybdopterin cofactor binding site; other site 886882010800 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 886882010801 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 886882010802 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 886882010803 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 886882010804 molybdopterin cofactor binding site; other site 886882010805 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 886882010806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882010807 putative PBP binding loops; other site 886882010808 ABC-ATPase subunit interface; other site 886882010809 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 886882010810 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 886882010811 iron-sulfur cluster repair di-iron protein; Region: FeS_repair_RIC; TIGR03652 886882010812 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 886882010813 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 886882010814 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 886882010815 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 886882010816 radical SAM protein, BA_1875 family; Region: sam_11; TIGR04053 886882010817 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882010818 FeS/SAM binding site; other site 886882010819 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 886882010820 YwiC-like protein; Region: YwiC; pfam14256 886882010821 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 886882010822 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 886882010823 FtsZ protein binding site [polypeptide binding]; other site 886882010824 phosphatidylinositol phosphate kinase; Provisional; Region: PLN03185 886882010825 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 886882010826 transaminase; Reviewed; Region: PRK08068 886882010827 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882010828 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882010829 homodimer interface [polypeptide binding]; other site 886882010830 catalytic residue [active] 886882010831 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 886882010832 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 886882010833 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 886882010834 Protein of unknown function (DUF1541); Region: DUF1541; pfam07563 886882010835 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 886882010836 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 886882010837 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 886882010838 DNA binding site [nucleotide binding] 886882010839 active site 886882010840 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 886882010841 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 886882010842 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882010843 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882010844 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 886882010845 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 886882010846 tetramer interface [polypeptide binding]; other site 886882010847 active site 886882010848 Mg2+/Mn2+ binding site [ion binding]; other site 886882010849 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 886882010850 catalytic residue [active] 886882010851 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882010852 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882010853 putative substrate translocation pore; other site 886882010854 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882010855 putative DNA binding site [nucleotide binding]; other site 886882010856 dimerization interface [polypeptide binding]; other site 886882010857 putative Zn2+ binding site [ion binding]; other site 886882010858 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 886882010859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882010860 NAD(P) binding site [chemical binding]; other site 886882010861 active site 886882010862 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 886882010863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882010864 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882010865 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882010866 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882010867 DNA binding site [nucleotide binding] 886882010868 domain linker motif; other site 886882010869 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 886882010870 ligand binding site [chemical binding]; other site 886882010871 dimerization interface [polypeptide binding]; other site 886882010872 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 886882010873 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 886882010874 putative NAD(P) binding site [chemical binding]; other site 886882010875 catalytic Zn binding site [ion binding]; other site 886882010876 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882010877 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882010878 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 886882010879 Periplasmic binding protein FeuA. These proteins have predicted to function as initial receptors in ABC transport of metal ions in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct...; Region: FeuA; cd01138 886882010880 putative ligand binding residues [chemical binding]; other site 886882010881 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 886882010882 Spore germination protein; Region: Spore_permease; cl17796 886882010883 VanZ like family; Region: VanZ; pfam04892 886882010884 RDD family; Region: RDD; pfam06271 886882010885 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 886882010886 dimer interface [polypeptide binding]; other site 886882010887 FMN binding site [chemical binding]; other site 886882010888 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882010889 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882010890 dimerization interface [polypeptide binding]; other site 886882010891 putative DNA binding site [nucleotide binding]; other site 886882010892 putative Zn2+ binding site [ion binding]; other site 886882010893 glutamate dehydrogenase; Provisional; Region: PRK09414 886882010894 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 886882010895 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 886882010896 NAD(P) binding site [chemical binding]; other site 886882010897 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 886882010898 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 886882010899 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882010900 catalytic residue [active] 886882010901 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 886882010902 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 886882010903 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882010904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882010905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 886882010906 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882010907 Right handed beta helix region; Region: Beta_helix; pfam13229 886882010908 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 886882010909 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; cl01382 886882010910 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 886882010911 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 886882010912 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 886882010913 DGC domain; Region: DGC; pfam08859 886882010914 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 886882010915 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882010916 catalytic residue [active] 886882010917 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882010918 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882010919 Peptidase family M23; Region: Peptidase_M23; pfam01551 886882010920 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 886882010921 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 886882010922 Protein of unknown function, DUF393; Region: DUF393; pfam04134 886882010923 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 886882010924 putative dimer interface [polypeptide binding]; other site 886882010925 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 886882010926 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 886882010927 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 886882010928 conserved cys residue [active] 886882010929 Predicted transcriptional regulator [Transcription]; Region: COG2378 886882010930 HTH domain; Region: HTH_11; pfam08279 886882010931 WYL domain; Region: WYL; pfam13280 886882010932 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 886882010933 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 886882010934 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 886882010935 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 886882010936 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 886882010937 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 886882010938 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 886882010939 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 886882010940 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 886882010941 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 886882010942 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 886882010943 The BURPS668_1122 family of deaminases; Region: Toxin-deaminase; pfam14424 886882010944 Immunity protein Imm3; Region: Imm3; pfam14425 886882010945 Immunity protein Imm3; Region: Imm3; pfam14425 886882010946 Domain of unknown function (DUF4261); Region: DUF4261; pfam14080 886882010947 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882010948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882010949 dimer interface [polypeptide binding]; other site 886882010950 conserved gate region; other site 886882010951 putative PBP binding loops; other site 886882010952 ABC-ATPase subunit interface; other site 886882010953 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882010954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882010955 dimer interface [polypeptide binding]; other site 886882010956 conserved gate region; other site 886882010957 putative PBP binding loops; other site 886882010958 ABC-ATPase subunit interface; other site 886882010959 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882010960 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882010961 Response regulator receiver domain; Region: Response_reg; pfam00072 886882010962 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882010963 active site 886882010964 phosphorylation site [posttranslational modification] 886882010965 intermolecular recognition site; other site 886882010966 dimerization interface [polypeptide binding]; other site 886882010967 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882010968 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882010969 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882010970 Histidine kinase; Region: His_kinase; pfam06580 886882010971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882010972 ATP binding site [chemical binding]; other site 886882010973 Mg2+ binding site [ion binding]; other site 886882010974 G-X-G motif; other site 886882010975 HEAT repeats; Region: HEAT_2; pfam13646 886882010976 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 886882010977 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 886882010978 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882010979 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882010980 DNA binding site [nucleotide binding] 886882010981 domain linker motif; other site 886882010982 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 886882010983 putative dimerization interface [polypeptide binding]; other site 886882010984 putative ligand binding site [chemical binding]; other site 886882010985 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 886882010986 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 886882010987 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 886882010988 Active_site [active] 886882010989 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 886882010990 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 886882010991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882010992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882010993 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 886882010994 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 886882010995 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 886882010996 Domain of unknown function (DUF4183); Region: DUF4183; pfam13799 886882010997 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 886882010998 Amb_all domain; Region: Amb_all; smart00656 886882010999 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 886882011000 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 886882011001 Walker A/P-loop; other site 886882011002 ATP binding site [chemical binding]; other site 886882011003 Q-loop/lid; other site 886882011004 ABC transporter signature motif; other site 886882011005 Walker B; other site 886882011006 D-loop; other site 886882011007 H-loop/switch region; other site 886882011008 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 886882011009 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 886882011010 HAMP domain; Region: HAMP; pfam00672 886882011011 dimerization interface [polypeptide binding]; other site 886882011012 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882011013 dimer interface [polypeptide binding]; other site 886882011014 phosphorylation site [posttranslational modification] 886882011015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882011016 ATP binding site [chemical binding]; other site 886882011017 Mg2+ binding site [ion binding]; other site 886882011018 G-X-G motif; other site 886882011019 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882011020 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882011021 active site 886882011022 phosphorylation site [posttranslational modification] 886882011023 intermolecular recognition site; other site 886882011024 dimerization interface [polypeptide binding]; other site 886882011025 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882011026 DNA binding site [nucleotide binding] 886882011027 H-type lectin domain; Region: H_lectin; pfam09458 886882011028 trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656 886882011029 NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242 886882011030 Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241 886882011031 Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055 886882011032 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 886882011033 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 886882011034 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 886882011035 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 886882011036 active site 886882011037 catalytic triad [active] 886882011038 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 886882011039 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882011040 Interdomain contacts; other site 886882011041 Cytokine receptor motif; other site 886882011042 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4412 886882011043 Immune inhibitor A peptidase M6; Region: Peptidase_M6; cl11525 886882011044 Cna protein B-type domain; Region: Cna_B_2; pfam13715 886882011045 Cna protein B-type domain; Region: Cna_B_2; pfam13715 886882011046 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 886882011047 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 886882011048 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 886882011049 active site 886882011050 catalytic triad [active] 886882011051 putative transporter; Provisional; Region: PRK11660 886882011052 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 886882011053 Sulfate transporter family; Region: Sulfate_transp; pfam00916 886882011054 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 886882011055 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882011056 dimerization interface [polypeptide binding]; other site 886882011057 putative DNA binding site [nucleotide binding]; other site 886882011058 putative Zn2+ binding site [ion binding]; other site 886882011059 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 886882011060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882011061 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 886882011062 Walker A motif; other site 886882011063 ATP binding site [chemical binding]; other site 886882011064 Walker B motif; other site 886882011065 arginine finger; other site 886882011066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882011067 putative substrate translocation pore; other site 886882011068 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882011069 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 886882011070 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 886882011071 Walker A/P-loop; other site 886882011072 ATP binding site [chemical binding]; other site 886882011073 Q-loop/lid; other site 886882011074 ABC transporter signature motif; other site 886882011075 Walker B; other site 886882011076 D-loop; other site 886882011077 H-loop/switch region; other site 886882011078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882011079 dimer interface [polypeptide binding]; other site 886882011080 conserved gate region; other site 886882011081 putative PBP binding loops; other site 886882011082 ABC-ATPase subunit interface; other site 886882011083 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 886882011084 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 886882011085 substrate binding pocket [chemical binding]; other site 886882011086 membrane-bound complex binding site; other site 886882011087 hinge residues; other site 886882011088 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882011089 H+ Antiporter protein; Region: 2A0121; TIGR00900 886882011090 putative substrate translocation pore; other site 886882011091 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 886882011092 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 886882011093 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 886882011094 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 886882011095 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 886882011096 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 886882011097 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 886882011098 Cellulose binding domain; Region: CBM_3; pfam00942 886882011099 dihydroxyacetone kinase; Provisional; Region: PRK14479 886882011100 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 886882011101 DAK2 domain; Region: Dak2; pfam02734 886882011102 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 886882011103 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 886882011104 dimer interface [polypeptide binding]; other site 886882011105 active site 886882011106 metal binding site [ion binding]; metal-binding site 886882011107 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 886882011108 Sensory domain found in PocR; Region: PocR; pfam10114 886882011109 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882011110 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882011111 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882011112 Protein of unknown function (DUF2167); Region: DUF2167; cl01938 886882011113 RDD family; Region: RDD; pfam06271 886882011114 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 886882011115 nucleotide binding site [chemical binding]; other site 886882011116 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 886882011117 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 886882011118 active site 886882011119 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 886882011120 phosphopeptide binding site; other site 886882011121 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 886882011122 phosphopeptide binding site; other site 886882011123 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 886882011124 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 886882011125 HSP70 interaction site [polypeptide binding]; other site 886882011126 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 886882011127 metal ion-dependent adhesion site (MIDAS); other site 886882011128 Catalytic domain of Protein Kinases; Region: PKc; cd00180 886882011129 active site 886882011130 ATP binding site [chemical binding]; other site 886882011131 substrate binding site [chemical binding]; other site 886882011132 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 886882011133 activation loop (A-loop); other site 886882011134 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 886882011135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882011136 putative substrate translocation pore; other site 886882011137 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 886882011138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882011139 active site 886882011140 phosphorylation site [posttranslational modification] 886882011141 intermolecular recognition site; other site 886882011142 dimerization interface [polypeptide binding]; other site 886882011143 LytTr DNA-binding domain; Region: LytTR; smart00850 886882011144 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 886882011145 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 886882011146 GAF domain; Region: GAF_3; pfam13492 886882011147 Histidine kinase; Region: His_kinase; pfam06580 886882011148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882011149 ATP binding site [chemical binding]; other site 886882011150 Mg2+ binding site [ion binding]; other site 886882011151 G-X-G motif; other site 886882011152 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 886882011153 putative dimer interface [polypeptide binding]; other site 886882011154 catalytic triad [active] 886882011155 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882011156 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882011157 dimer interface [polypeptide binding]; other site 886882011158 putative CheW interface [polypeptide binding]; other site 886882011159 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 886882011160 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 886882011161 5S rRNA interface [nucleotide binding]; other site 886882011162 CTC domain interface [polypeptide binding]; other site 886882011163 L16 interface [polypeptide binding]; other site 886882011164 pullulanase, type I; Region: pulA_typeI; TIGR02104 886882011165 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 886882011166 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 886882011167 Ca binding site [ion binding]; other site 886882011168 active site 886882011169 catalytic site [active] 886882011170 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 886882011171 carbohydrate binding site [chemical binding]; other site 886882011172 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 886882011173 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882011174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882011175 Walker A/P-loop; other site 886882011176 ATP binding site [chemical binding]; other site 886882011177 Q-loop/lid; other site 886882011178 ABC transporter signature motif; other site 886882011179 Walker B; other site 886882011180 D-loop; other site 886882011181 H-loop/switch region; other site 886882011182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 886882011183 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882011184 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 886882011185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882011186 Walker A/P-loop; other site 886882011187 ATP binding site [chemical binding]; other site 886882011188 Q-loop/lid; other site 886882011189 ABC transporter signature motif; other site 886882011190 Walker B; other site 886882011191 D-loop; other site 886882011192 H-loop/switch region; other site 886882011193 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 886882011194 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 886882011195 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 886882011196 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 886882011197 active site 886882011198 phosphorylation site [posttranslational modification] 886882011199 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 886882011200 HTH domain; Region: HTH_11; pfam08279 886882011201 PRD domain; Region: PRD; pfam00874 886882011202 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 886882011203 active site 886882011204 P-loop; other site 886882011205 phosphorylation site [posttranslational modification] 886882011206 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 886882011207 active site 886882011208 phosphorylation site [posttranslational modification] 886882011209 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 886882011210 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 886882011211 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 886882011212 active site 886882011213 P-loop; other site 886882011214 phosphorylation site [posttranslational modification] 886882011215 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 886882011216 lipoyl attachment site [posttranslational modification]; other site 886882011217 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 886882011218 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 886882011219 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 886882011220 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 886882011221 tetramer interface [polypeptide binding]; other site 886882011222 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882011223 catalytic residue [active] 886882011224 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 886882011225 tetramer interface [polypeptide binding]; other site 886882011226 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882011227 catalytic residue [active] 886882011228 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 886882011229 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 886882011230 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 886882011231 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 886882011232 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 886882011233 dimerization domain swap beta strand [polypeptide binding]; other site 886882011234 regulatory protein interface [polypeptide binding]; other site 886882011235 active site 886882011236 regulatory phosphorylation site [posttranslational modification]; other site 886882011237 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882011238 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 886882011239 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 886882011240 active site turn [active] 886882011241 phosphorylation site [posttranslational modification] 886882011242 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 886882011243 HPr interaction site; other site 886882011244 glycerol kinase (GK) interaction site [polypeptide binding]; other site 886882011245 active site 886882011246 phosphorylation site [posttranslational modification] 886882011247 transcriptional antiterminator BglG; Provisional; Region: PRK09772 886882011248 CAT RNA binding domain; Region: CAT_RBD; pfam03123 886882011249 PRD domain; Region: PRD; pfam00874 886882011250 PRD domain; Region: PRD; pfam00874 886882011251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 886882011252 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 886882011253 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 886882011254 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 886882011255 dimer interface [polypeptide binding]; other site 886882011256 active site 886882011257 metal binding site [ion binding]; metal-binding site 886882011258 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 886882011259 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 886882011260 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 886882011261 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 886882011262 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 886882011263 NAD binding site [chemical binding]; other site 886882011264 homodimer interface [polypeptide binding]; other site 886882011265 active site 886882011266 substrate binding site [chemical binding]; other site 886882011267 galactokinase; Provisional; Region: PRK05322 886882011268 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 886882011269 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 886882011270 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 886882011271 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882011272 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882011273 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882011274 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882011275 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 886882011276 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 886882011277 active site 886882011278 catalytic tetrad [active] 886882011279 NAD-dependent deacetylase; Provisional; Region: PRK00481 886882011280 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 886882011281 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 886882011282 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882011283 motif II; other site 886882011284 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 886882011285 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 886882011286 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 886882011287 General stress protein [General function prediction only]; Region: GsiB; COG3729 886882011288 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 886882011289 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 886882011290 Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959 886882011291 NodB motif; other site 886882011292 putative active site [active] 886882011293 putative catalytic site [active] 886882011294 putative Zn binding site [ion binding]; other site 886882011295 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 886882011296 Domain of unknown function DUF20; Region: UPF0118; pfam01594 886882011297 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 886882011298 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 886882011299 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 886882011300 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882011301 dimerization interface [polypeptide binding]; other site 886882011302 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882011303 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882011304 dimer interface [polypeptide binding]; other site 886882011305 putative CheW interface [polypeptide binding]; other site 886882011306 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 886882011307 Peptidase family U32; Region: Peptidase_U32; pfam01136 886882011308 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 886882011309 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 886882011310 Peptidase family U32; Region: Peptidase_U32; pfam01136 886882011311 YceG-like family; Region: YceG; pfam02618 886882011312 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 886882011313 dimerization interface [polypeptide binding]; other site 886882011314 Protein of unknown function (DUF1292); Region: DUF1292; cl01608 886882011315 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 886882011316 hypothetical protein; Provisional; Region: PRK05473 886882011317 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 886882011318 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 886882011319 motif 1; other site 886882011320 active site 886882011321 motif 2; other site 886882011322 motif 3; other site 886882011323 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 886882011324 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 886882011325 Domain of unknown function DUF20; Region: UPF0118; pfam01594 886882011326 Cache domain; Region: Cache_1; pfam02743 886882011327 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 886882011328 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882011329 dimerization interface [polypeptide binding]; other site 886882011330 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882011331 dimer interface [polypeptide binding]; other site 886882011332 putative CheW interface [polypeptide binding]; other site 886882011333 PRC-barrel domain; Region: PRC; pfam05239 886882011334 PRC-barrel domain; Region: PRC; pfam05239 886882011335 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 886882011336 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 886882011337 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 886882011338 catalytic residue [active] 886882011339 Predicted transcriptional regulator [Transcription]; Region: COG1959 886882011340 Transcriptional regulator; Region: Rrf2; pfam02082 886882011341 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 886882011342 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 886882011343 DinB superfamily; Region: DinB_2; pfam12867 886882011344 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 886882011345 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 886882011346 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 886882011347 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 886882011348 recombination factor protein RarA; Reviewed; Region: PRK13342 886882011349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882011350 Walker A motif; other site 886882011351 ATP binding site [chemical binding]; other site 886882011352 Walker B motif; other site 886882011353 arginine finger; other site 886882011354 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 886882011355 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 886882011356 Part of AAA domain; Region: AAA_19; pfam13245 886882011357 Family description; Region: UvrD_C_2; pfam13538 886882011358 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882011359 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882011360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882011361 Walker A/P-loop; other site 886882011362 ATP binding site [chemical binding]; other site 886882011363 Q-loop/lid; other site 886882011364 ABC transporter signature motif; other site 886882011365 Walker B; other site 886882011366 D-loop; other site 886882011367 H-loop/switch region; other site 886882011368 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 886882011369 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179 886882011370 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 886882011371 putative ATP binding site [chemical binding]; other site 886882011372 putative substrate interface [chemical binding]; other site 886882011373 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 886882011374 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 886882011375 dimer interface [polypeptide binding]; other site 886882011376 anticodon binding site; other site 886882011377 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 886882011378 homodimer interface [polypeptide binding]; other site 886882011379 motif 1; other site 886882011380 active site 886882011381 motif 2; other site 886882011382 GAD domain; Region: GAD; pfam02938 886882011383 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 886882011384 motif 3; other site 886882011385 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 886882011386 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 886882011387 dimer interface [polypeptide binding]; other site 886882011388 motif 1; other site 886882011389 active site 886882011390 motif 2; other site 886882011391 motif 3; other site 886882011392 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 886882011393 anticodon binding site; other site 886882011394 intracellular protease, PfpI family; Region: PfpI; TIGR01382 886882011395 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 886882011396 proposed catalytic triad [active] 886882011397 conserved cys residue [active] 886882011398 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 886882011399 putative active site [active] 886882011400 dimerization interface [polypeptide binding]; other site 886882011401 putative tRNAtyr binding site [nucleotide binding]; other site 886882011402 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 886882011403 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882011404 Zn2+ binding site [ion binding]; other site 886882011405 Mg2+ binding site [ion binding]; other site 886882011406 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 886882011407 synthetase active site [active] 886882011408 NTP binding site [chemical binding]; other site 886882011409 metal binding site [ion binding]; metal-binding site 886882011410 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 886882011411 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 886882011412 uracil transporter; Provisional; Region: PRK10720 886882011413 Cache domain; Region: Cache_1; pfam02743 886882011414 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 886882011415 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882011416 dimerization interface [polypeptide binding]; other site 886882011417 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882011418 dimer interface [polypeptide binding]; other site 886882011419 putative CheW interface [polypeptide binding]; other site 886882011420 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 886882011421 active site 886882011422 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 886882011423 DHH family; Region: DHH; pfam01368 886882011424 DHHA1 domain; Region: DHHA1; pfam02272 886882011425 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538 886882011426 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 886882011427 Cation efflux family; Region: Cation_efflux; pfam01545 886882011428 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 886882011429 Protein export membrane protein; Region: SecD_SecF; pfam02355 886882011430 protein-export membrane protein SecD; Region: secD; TIGR01129 886882011431 Class I aldolases; Region: Aldolase_Class_I; cl17187 886882011432 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 886882011433 Post-transcriptional regulator; Region: Post_transc_reg; pfam13797 886882011434 stage V sporulation protein B; Region: spore_V_B; TIGR02900 886882011435 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 886882011436 Predicted membrane protein [Function unknown]; Region: COG2323 886882011437 putative membrane protein, TIGR04086 family; Region: TIGR04086_membr 886882011438 Preprotein translocase subunit; Region: YajC; pfam02699 886882011439 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 886882011440 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 886882011441 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 886882011442 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 886882011443 Stage II sporulation protein; Region: SpoIID; pfam08486 886882011444 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 886882011445 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 886882011446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882011447 Walker A motif; other site 886882011448 ATP binding site [chemical binding]; other site 886882011449 Walker B motif; other site 886882011450 arginine finger; other site 886882011451 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 886882011452 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 886882011453 RuvA N terminal domain; Region: RuvA_N; pfam01330 886882011454 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 886882011455 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 886882011456 active site 886882011457 putative DNA-binding cleft [nucleotide binding]; other site 886882011458 dimer interface [polypeptide binding]; other site 886882011459 BofC C-terminal domain; Region: BofC_C; pfam08955 886882011460 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 886882011461 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 886882011462 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 886882011463 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 886882011464 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 886882011465 homodimer interface [polypeptide binding]; other site 886882011466 substrate-cofactor binding pocket; other site 886882011467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882011468 catalytic residue [active] 886882011469 prephenate dehydratase; Provisional; Region: PRK11898 886882011470 Prephenate dehydratase; Region: PDT; pfam00800 886882011471 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 886882011472 putative L-Phe binding site [chemical binding]; other site 886882011473 homoserine kinase; Provisional; Region: PRK01212 886882011474 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 886882011475 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 886882011476 homoserine dehydrogenase; Provisional; Region: PRK06349 886882011477 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 886882011478 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 886882011479 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 886882011480 hypothetical protein; Provisional; Region: PRK04435 886882011481 C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888 886882011482 GTPase CgtA; Reviewed; Region: obgE; PRK12297 886882011483 GTP1/OBG; Region: GTP1_OBG; pfam01018 886882011484 Obg GTPase; Region: Obg; cd01898 886882011485 G1 box; other site 886882011486 GTP/Mg2+ binding site [chemical binding]; other site 886882011487 Switch I region; other site 886882011488 G2 box; other site 886882011489 G3 box; other site 886882011490 Switch II region; other site 886882011491 G4 box; other site 886882011492 G5 box; other site 886882011493 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 886882011494 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 886882011495 Protein of unknown function (DUF464); Region: DUF464; pfam04327 886882011496 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 886882011497 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 886882011498 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 886882011499 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 886882011500 homodimer interface [polypeptide binding]; other site 886882011501 oligonucleotide binding site [chemical binding]; other site 886882011502 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161 886882011503 Peptidase family M50; Region: Peptidase_M50; pfam02163 886882011504 active site 886882011505 putative substrate binding region [chemical binding]; other site 886882011506 Peptidase family M23; Region: Peptidase_M23; pfam01551 886882011507 Septum formation inhibitor-activating ATPase [Cell division and chromosome partitioning]; Region: MinD; COG2894 886882011508 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 886882011509 Switch I; other site 886882011510 Switch II; other site 886882011511 septum formation inhibitor; Reviewed; Region: minC; PRK00513 886882011512 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 886882011513 rod shape-determining protein MreD; Region: MreD; cl01087 886882011514 rod shape-determining protein MreC; Provisional; Region: PRK13922 886882011515 rod shape-determining protein MreC; Region: MreC; pfam04085 886882011516 rod shape-determining protein MreB; Provisional; Region: PRK13927 886882011517 MreB and similar proteins; Region: MreB_like; cd10225 886882011518 nucleotide binding site [chemical binding]; other site 886882011519 Mg binding site [ion binding]; other site 886882011520 putative protofilament interaction site [polypeptide binding]; other site 886882011521 RodZ interaction site [polypeptide binding]; other site 886882011522 hypothetical protein; Reviewed; Region: PRK00024 886882011523 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 886882011524 MPN+ (JAMM) motif; other site 886882011525 Zinc-binding site [ion binding]; other site 886882011526 Maf-like protein; Reviewed; Region: PRK00078 886882011527 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 886882011528 active site 886882011529 dimer interface [polypeptide binding]; other site 886882011530 Domain of unknown function (DUF4321); Region: DUF4321; pfam14209 886882011531 Sporulation related domain; Region: SPOR; pfam05036 886882011532 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 886882011533 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 886882011534 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 886882011535 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 886882011536 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 886882011537 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 886882011538 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 886882011539 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 886882011540 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 886882011541 active site 886882011542 HIGH motif; other site 886882011543 nucleotide binding site [chemical binding]; other site 886882011544 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 886882011545 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 886882011546 active site 886882011547 KMSKS motif; other site 886882011548 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 886882011549 tRNA binding surface [nucleotide binding]; other site 886882011550 anticodon binding site; other site 886882011551 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 886882011552 stage VI sporulation protein D; Region: spore_VI_D; TIGR02907 886882011553 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 886882011554 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 886882011555 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 886882011556 active site 886882011557 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 886882011558 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 886882011559 inhibitor-cofactor binding pocket; inhibition site 886882011560 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882011561 catalytic residue [active] 886882011562 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 886882011563 dimer interface [polypeptide binding]; other site 886882011564 active site 886882011565 Schiff base residues; other site 886882011566 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 886882011567 active site 886882011568 SAM binding site [chemical binding]; other site 886882011569 homodimer interface [polypeptide binding]; other site 886882011570 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 886882011571 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 886882011572 active site 886882011573 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 886882011574 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 886882011575 domain interfaces; other site 886882011576 active site 886882011577 precorrin-2 dehydrogenase; Reviewed; Region: PRK06718 886882011578 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 886882011579 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 886882011580 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 886882011581 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 886882011582 tRNA; other site 886882011583 putative tRNA binding site [nucleotide binding]; other site 886882011584 putative NADP binding site [chemical binding]; other site 886882011585 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 886882011586 S-adenosylmethionine decarboxylase proenzyme; Validated; Region: PRK01706 886882011587 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 886882011588 G1 box; other site 886882011589 GTP/Mg2+ binding site [chemical binding]; other site 886882011590 Switch I region; other site 886882011591 G2 box; other site 886882011592 G3 box; other site 886882011593 Switch II region; other site 886882011594 G4 box; other site 886882011595 G5 box; other site 886882011596 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 886882011597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882011598 Walker A motif; other site 886882011599 ATP binding site [chemical binding]; other site 886882011600 Walker B motif; other site 886882011601 arginine finger; other site 886882011602 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 886882011603 ATP-dependent protease LonB; Region: spore_lonB; TIGR02902 886882011604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882011605 Walker A motif; other site 886882011606 ATP binding site [chemical binding]; other site 886882011607 Walker B motif; other site 886882011608 arginine finger; other site 886882011609 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 886882011610 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 886882011611 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 886882011612 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 886882011613 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 886882011614 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 886882011615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882011616 Walker A motif; other site 886882011617 ATP binding site [chemical binding]; other site 886882011618 Walker B motif; other site 886882011619 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 886882011620 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 886882011621 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 886882011622 oligomer interface [polypeptide binding]; other site 886882011623 active site residues [active] 886882011624 trigger factor; Provisional; Region: tig; PRK01490 886882011625 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 886882011626 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 886882011627 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 886882011628 active site 886882011629 putative catalytic site [active] 886882011630 DNA binding site [nucleotide binding] 886882011631 putative phosphate binding site [ion binding]; other site 886882011632 metal binding site A [ion binding]; metal-binding site 886882011633 AP binding site [nucleotide binding]; other site 886882011634 metal binding site B [ion binding]; metal-binding site 886882011635 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 886882011636 beta-galactosidase; Region: BGL; TIGR03356 886882011637 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882011638 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882011639 DNA binding site [nucleotide binding] 886882011640 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 886882011641 dimerization interface [polypeptide binding]; other site 886882011642 ligand binding site [chemical binding]; other site 886882011643 glycerol kinase; Provisional; Region: glpK; PRK00047 886882011644 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 886882011645 N- and C-terminal domain interface [polypeptide binding]; other site 886882011646 active site 886882011647 MgATP binding site [chemical binding]; other site 886882011648 catalytic site [active] 886882011649 metal binding site [ion binding]; metal-binding site 886882011650 glycerol binding site [chemical binding]; other site 886882011651 homotetramer interface [polypeptide binding]; other site 886882011652 homodimer interface [polypeptide binding]; other site 886882011653 FBP binding site [chemical binding]; other site 886882011654 protein IIAGlc interface [polypeptide binding]; other site 886882011655 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 886882011656 amphipathic channel; other site 886882011657 Asn-Pro-Ala signature motifs; other site 886882011658 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 886882011659 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882011660 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 886882011661 active site turn [active] 886882011662 phosphorylation site [posttranslational modification] 886882011663 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 886882011664 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882011665 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882011666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882011667 dimer interface [polypeptide binding]; other site 886882011668 ABC-ATPase subunit interface; other site 886882011669 putative PBP binding loops; other site 886882011670 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882011671 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882011672 dimer interface [polypeptide binding]; other site 886882011673 conserved gate region; other site 886882011674 putative PBP binding loops; other site 886882011675 ABC-ATPase subunit interface; other site 886882011676 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 886882011677 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882011678 FeS/SAM binding site; other site 886882011679 Domain of unknown function (DUF4008); Region: DUF4008; cl14869 886882011680 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882011681 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 886882011682 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 886882011683 Walker A/P-loop; other site 886882011684 ATP binding site [chemical binding]; other site 886882011685 Q-loop/lid; other site 886882011686 ABC transporter signature motif; other site 886882011687 Walker B; other site 886882011688 D-loop; other site 886882011689 H-loop/switch region; other site 886882011690 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 886882011691 radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334 886882011692 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882011693 FeS/SAM binding site; other site 886882011694 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 886882011695 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 886882011696 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882011697 active site 886882011698 phosphorylation site [posttranslational modification] 886882011699 intermolecular recognition site; other site 886882011700 dimerization interface [polypeptide binding]; other site 886882011701 LytTr DNA-binding domain; Region: LytTR; smart00850 886882011702 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 886882011703 ATP binding site [chemical binding]; other site 886882011704 Mg2+ binding site [ion binding]; other site 886882011705 G-X-G motif; other site 886882011706 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 886882011707 amino acid carrier protein; Region: agcS; TIGR00835 886882011708 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 886882011709 beta-galactosidase; Region: BGL; TIGR03356 886882011710 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882011711 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882011712 DNA binding site [nucleotide binding] 886882011713 domain linker motif; other site 886882011714 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 886882011715 CAT RNA binding domain; Region: CAT_RBD; smart01061 886882011716 transcriptional antiterminator BglG; Provisional; Region: PRK09772 886882011717 PRD domain; Region: PRD; pfam00874 886882011718 PRD domain; Region: PRD; pfam00874 886882011719 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 886882011720 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 886882011721 active site turn [active] 886882011722 phosphorylation site [posttranslational modification] 886882011723 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882011724 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 886882011725 HPr interaction site; other site 886882011726 glycerol kinase (GK) interaction site [polypeptide binding]; other site 886882011727 active site 886882011728 phosphorylation site [posttranslational modification] 886882011729 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 886882011730 catalytic residues [active] 886882011731 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 886882011732 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 886882011733 active site 886882011734 Cupin domain; Region: Cupin_2; cl17218 886882011735 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882011736 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882011737 active site 886882011738 phosphorylation site [posttranslational modification] 886882011739 intermolecular recognition site; other site 886882011740 dimerization interface [polypeptide binding]; other site 886882011741 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882011742 DNA binding site [nucleotide binding] 886882011743 Response regulator receiver domain; Region: Response_reg; pfam00072 886882011744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882011745 active site 886882011746 phosphorylation site [posttranslational modification] 886882011747 intermolecular recognition site; other site 886882011748 dimerization interface [polypeptide binding]; other site 886882011749 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 886882011750 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 886882011751 active site 886882011752 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 886882011753 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 886882011754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 886882011755 active site 886882011756 malate dehydrogenase; Provisional; Region: PRK13529 886882011757 Malic enzyme, N-terminal domain; Region: malic; pfam00390 886882011758 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 886882011759 NAD(P) binding site [chemical binding]; other site 886882011760 Putative transcription activator [Transcription]; Region: TenA; COG0819 886882011761 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 886882011762 substrate binding site [chemical binding]; other site 886882011763 multimerization interface [polypeptide binding]; other site 886882011764 ATP binding site [chemical binding]; other site 886882011765 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 886882011766 dimer interface [polypeptide binding]; other site 886882011767 substrate binding site [chemical binding]; other site 886882011768 ATP binding site [chemical binding]; other site 886882011769 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 886882011770 thiamine phosphate binding site [chemical binding]; other site 886882011771 active site 886882011772 pyrophosphate binding site [ion binding]; other site 886882011773 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882011774 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882011775 dimerization interface [polypeptide binding]; other site 886882011776 putative DNA binding site [nucleotide binding]; other site 886882011777 putative Zn2+ binding site [ion binding]; other site 886882011778 Arginase-like amidino hydrolase family; Region: Arginase-like_1; cd09999 886882011779 active site 886882011780 Mn binding site [ion binding]; other site 886882011781 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882011782 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882011783 DNA binding site [nucleotide binding] 886882011784 domain linker motif; other site 886882011785 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 886882011786 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 886882011787 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 886882011788 NAD binding site [chemical binding]; other site 886882011789 sugar binding site [chemical binding]; other site 886882011790 divalent metal binding site [ion binding]; other site 886882011791 tetramer (dimer of dimers) interface [polypeptide binding]; other site 886882011792 dimer interface [polypeptide binding]; other site 886882011793 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 886882011794 active site 886882011795 asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536 886882011796 dimer interface [polypeptide binding]; other site 886882011797 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 886882011798 Ligand Binding Site [chemical binding]; other site 886882011799 Molecular Tunnel; other site 886882011800 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 886882011801 active site 886882011802 dimerization interface [polypeptide binding]; other site 886882011803 ribonuclease PH; Reviewed; Region: rph; PRK00173 886882011804 Ribonuclease PH; Region: RNase_PH_bact; cd11362 886882011805 hexamer interface [polypeptide binding]; other site 886882011806 active site 886882011807 Spore germination protein [General function prediction only]; Region: COG5401 886882011808 Sporulation and spore germination; Region: Germane; pfam10646 886882011809 Sporulation and spore germination; Region: Germane; pfam10646 886882011810 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 886882011811 tetramer interfaces [polypeptide binding]; other site 886882011812 binuclear metal-binding site [ion binding]; other site 886882011813 putative acetyltransferase; Provisional; Region: PRK03624 886882011814 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882011815 Coenzyme A binding pocket [chemical binding]; other site 886882011816 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 886882011817 classical (c) SDRs; Region: SDR_c; cd05233 886882011818 NAD(P) binding site [chemical binding]; other site 886882011819 active site 886882011820 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882011821 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882011822 WHG domain; Region: WHG; pfam13305 886882011823 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 886882011824 NADH(P)-binding; Region: NAD_binding_10; pfam13460 886882011825 NAD binding site [chemical binding]; other site 886882011826 substrate binding site [chemical binding]; other site 886882011827 putative active site [active] 886882011828 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 886882011829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882011830 S-adenosylmethionine binding site [chemical binding]; other site 886882011831 Protein of unknown function DUF72; Region: DUF72; pfam01904 886882011832 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 886882011833 putative metal binding site; other site 886882011834 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 886882011835 binding surface 886882011836 TPR motif; other site 886882011837 Methyltransferase domain; Region: Methyltransf_23; pfam13489 886882011838 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882011839 S-adenosylmethionine binding site [chemical binding]; other site 886882011840 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 886882011841 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882011842 NAD(P) binding site [chemical binding]; other site 886882011843 active site 886882011844 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 886882011845 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 886882011846 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 886882011847 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 886882011848 NAD(P) binding site [chemical binding]; other site 886882011849 homodimer interface [polypeptide binding]; other site 886882011850 substrate binding site [chemical binding]; other site 886882011851 active site 886882011852 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 886882011853 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 886882011854 active site 886882011855 catalytic triad [active] 886882011856 oxyanion hole [active] 886882011857 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882011858 dimerization interface [polypeptide binding]; other site 886882011859 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882011860 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882011861 dimer interface [polypeptide binding]; other site 886882011862 putative CheW interface [polypeptide binding]; other site 886882011863 Putative motility protein; Region: YjfB_motility; pfam14070 886882011864 hypothetical protein; Provisional; Region: PRK08201 886882011865 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 886882011866 metal binding site [ion binding]; metal-binding site 886882011867 putative dimer interface [polypeptide binding]; other site 886882011868 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 886882011869 Methyltransferase domain; Region: Methyltransf_11; pfam08241 886882011870 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 886882011871 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 886882011872 DNA binding residues [nucleotide binding] 886882011873 dimerization interface [polypeptide binding]; other site 886882011874 Imelysin; Region: Peptidase_M75; pfam09375 886882011875 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 886882011876 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 886882011877 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 886882011878 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 886882011879 dimer interface [polypeptide binding]; other site 886882011880 active site 886882011881 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 886882011882 catalytic residues [active] 886882011883 substrate binding site [chemical binding]; other site 886882011884 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 886882011885 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882011886 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 886882011887 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 886882011888 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 886882011889 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 886882011890 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 886882011891 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 886882011892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882011893 Walker A/P-loop; other site 886882011894 ATP binding site [chemical binding]; other site 886882011895 Q-loop/lid; other site 886882011896 ABC transporter signature motif; other site 886882011897 Walker B; other site 886882011898 D-loop; other site 886882011899 H-loop/switch region; other site 886882011900 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 886882011901 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882011902 ATP-grasp domain; Region: ATP-grasp_4; cl17255 886882011903 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882011904 Radical SAM superfamily; Region: Radical_SAM; pfam04055 886882011905 FeS/SAM binding site; other site 886882011906 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 886882011907 acyl carrier protein; Provisional; Region: PRK07081 886882011908 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 886882011909 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 886882011910 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 886882011911 putative active site [active] 886882011912 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 886882011913 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 886882011914 active site 886882011915 trimer interface [polypeptide binding]; other site 886882011916 allosteric site; other site 886882011917 active site lid [active] 886882011918 hexamer (dimer of trimers) interface [polypeptide binding]; other site 886882011919 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 886882011920 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 886882011921 active site 886882011922 dimer interface [polypeptide binding]; other site 886882011923 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 886882011924 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580 886882011925 PGAP1-like protein; Region: PGAP1; pfam07819 886882011926 Homeodomain-like domain; Region: HTH_23; cl17451 886882011927 YvrJ protein family; Region: YvrJ; pfam12841 886882011928 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 886882011929 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 886882011930 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 886882011931 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 886882011932 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 886882011933 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 886882011934 Walker A/P-loop; other site 886882011935 ATP binding site [chemical binding]; other site 886882011936 Q-loop/lid; other site 886882011937 ABC transporter signature motif; other site 886882011938 Walker B; other site 886882011939 D-loop; other site 886882011940 H-loop/switch region; other site 886882011941 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 886882011942 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 886882011943 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 886882011944 HPr interaction site; other site 886882011945 glycerol kinase (GK) interaction site [polypeptide binding]; other site 886882011946 active site 886882011947 phosphorylation site [posttranslational modification] 886882011948 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882011949 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 886882011950 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 886882011951 active site turn [active] 886882011952 phosphorylation site [posttranslational modification] 886882011953 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 886882011954 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882011955 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882011956 DNA binding site [nucleotide binding] 886882011957 domain linker motif; other site 886882011958 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 886882011959 ligand binding site [chemical binding]; other site 886882011960 dimerization interface [polypeptide binding]; other site 886882011961 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 886882011962 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 886882011963 Rrf2 family protein; Region: rrf2_super; TIGR00738 886882011964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882011965 putative Zn2+ binding site [ion binding]; other site 886882011966 putative DNA binding site [nucleotide binding]; other site 886882011967 dimerization interface [polypeptide binding]; other site 886882011968 HTH domain; Region: HTH_11; pfam08279 886882011969 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 886882011970 Mga helix-turn-helix domain; Region: Mga; pfam05043 886882011971 PRD domain; Region: PRD; pfam00874 886882011972 PRD domain; Region: PRD; pfam00874 886882011973 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 886882011974 active site 886882011975 P-loop; other site 886882011976 phosphorylation site [posttranslational modification] 886882011977 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 886882011978 active site 886882011979 phosphorylation site [posttranslational modification] 886882011980 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 886882011981 active site 886882011982 methionine cluster; other site 886882011983 phosphorylation site [posttranslational modification] 886882011984 metal binding site [ion binding]; metal-binding site 886882011985 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 886882011986 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 886882011987 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 886882011988 beta-galactosidase; Region: BGL; TIGR03356 886882011989 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 886882011990 active site 886882011991 P-loop; other site 886882011992 phosphorylation site [posttranslational modification] 886882011993 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 886882011994 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882011995 NAD(P) binding site [chemical binding]; other site 886882011996 active site 886882011997 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 886882011998 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 886882011999 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 886882012000 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 886882012001 active site 886882012002 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 886882012003 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 886882012004 Probable Catalytic site; other site 886882012005 metal-binding site 886882012006 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 886882012007 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 886882012008 active site 886882012009 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882012010 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 886882012011 NAD(P) binding site [chemical binding]; other site 886882012012 active site 886882012013 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 886882012014 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 886882012015 NADP binding site [chemical binding]; other site 886882012016 active site 886882012017 putative substrate binding site [chemical binding]; other site 886882012018 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 886882012019 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 886882012020 NAD(P) binding site [chemical binding]; other site 886882012021 homodimer interface [polypeptide binding]; other site 886882012022 substrate binding site [chemical binding]; other site 886882012023 active site 886882012024 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 886882012025 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 886882012026 active site 886882012027 homodimer interface [polypeptide binding]; other site 886882012028 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 886882012029 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 886882012030 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 886882012031 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 886882012032 DUF based on E. rectale Gene description (DUF3880); Region: DUF3880; pfam12996 886882012033 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 886882012034 flagellar assembly protein H; Validated; Region: fliH; PRK05687 886882012035 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 886882012036 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 886882012037 active site 886882012038 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 886882012039 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 886882012040 active site 886882012041 Glycosyltransferase like family; Region: Glyco_tranf_2_5; pfam13712 886882012042 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 886882012043 Probable Catalytic site; other site 886882012044 metal-binding site 886882012045 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 886882012046 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 886882012047 active site 886882012048 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 886882012049 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 886882012050 active site 886882012051 Zinc metalloprotease (elastase) [Amino acid transport and metabolism]; Region: LasB; COG3227 886882012052 Fungalysin/Thermolysin Propeptide Motif; Region: FTP; pfam07504 886882012053 Peptidase M4 family includes thermolysin, protealysin, aureolysin and neutral protease; Region: M4_neutral_protease; cd09597 886882012054 active site 886882012055 Zn binding site [ion binding]; other site 886882012056 TraX protein; Region: TraX; cl05434 886882012057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 886882012058 Histidine kinase; Region: HisKA_3; pfam07730 886882012059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882012060 ATP binding site [chemical binding]; other site 886882012061 Mg2+ binding site [ion binding]; other site 886882012062 G-X-G motif; other site 886882012063 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 886882012064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882012065 active site 886882012066 phosphorylation site [posttranslational modification] 886882012067 intermolecular recognition site; other site 886882012068 dimerization interface [polypeptide binding]; other site 886882012069 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 886882012070 DNA binding residues [nucleotide binding] 886882012071 dimerization interface [polypeptide binding]; other site 886882012072 Putative sensor; Region: Sensor; pfam13796 886882012073 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 886882012074 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 886882012075 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 886882012076 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 886882012077 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882012078 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882012079 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882012080 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 886882012081 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 886882012082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882012083 homodimer interface [polypeptide binding]; other site 886882012084 catalytic residue [active] 886882012085 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 886882012086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882012087 dimer interface [polypeptide binding]; other site 886882012088 phosphorylation site [posttranslational modification] 886882012089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882012090 ATP binding site [chemical binding]; other site 886882012091 Mg2+ binding site [ion binding]; other site 886882012092 G-X-G motif; other site 886882012093 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 886882012094 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 886882012095 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 886882012096 Walker A/P-loop; other site 886882012097 ATP binding site [chemical binding]; other site 886882012098 Q-loop/lid; other site 886882012099 ABC transporter signature motif; other site 886882012100 Walker B; other site 886882012101 D-loop; other site 886882012102 H-loop/switch region; other site 886882012103 helicase 45; Provisional; Region: PTZ00424 886882012104 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 886882012105 ATP binding site [chemical binding]; other site 886882012106 Mg++ binding site [ion binding]; other site 886882012107 motif III; other site 886882012108 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882012109 nucleotide binding region [chemical binding]; other site 886882012110 ATP-binding site [chemical binding]; other site 886882012111 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 886882012112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882012113 NAD(P) binding site [chemical binding]; other site 886882012114 active site 886882012115 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 886882012116 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 886882012117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882012118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882012119 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882012120 dimerization interface [polypeptide binding]; other site 886882012121 histidinol-phosphatase; Provisional; Region: PRK07328 886882012122 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110 886882012123 active site 886882012124 dimer interface [polypeptide binding]; other site 886882012125 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 886882012126 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 886882012127 synthetase active site [active] 886882012128 NTP binding site [chemical binding]; other site 886882012129 metal binding site [ion binding]; metal-binding site 886882012130 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 886882012131 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 886882012132 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 886882012133 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 886882012134 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 886882012135 active site 886882012136 metal binding site [ion binding]; metal-binding site 886882012137 phosphodiesterase YaeI; Provisional; Region: PRK11340 886882012138 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 886882012139 putative active site [active] 886882012140 putative metal binding site [ion binding]; other site 886882012141 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 886882012142 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 886882012143 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 886882012144 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 886882012145 L-aspartate oxidase; Provisional; Region: PRK06175 886882012146 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 886882012147 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 886882012148 putative Iron-sulfur protein interface [polypeptide binding]; other site 886882012149 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 886882012150 proximal heme binding site [chemical binding]; other site 886882012151 distal heme binding site [chemical binding]; other site 886882012152 putative dimer interface [polypeptide binding]; other site 886882012153 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882012154 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882012155 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882012156 dimerization interface [polypeptide binding]; other site 886882012157 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 886882012158 TrkA-N domain; Region: TrkA_N; pfam02254 886882012159 TrkA-C domain; Region: TrkA_C; pfam02080 886882012160 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 886882012161 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 886882012162 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 886882012163 CAAX protease self-immunity; Region: Abi; pfam02517 886882012164 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 886882012165 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 886882012166 GIY-YIG motif/motif A; other site 886882012167 active site 886882012168 catalytic site [active] 886882012169 putative DNA binding site [nucleotide binding]; other site 886882012170 metal binding site [ion binding]; metal-binding site 886882012171 UvrB/uvrC motif; Region: UVR; pfam02151 886882012172 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 886882012173 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 886882012174 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 886882012175 catalytic residues [active] 886882012176 primosomal protein DnaI; Reviewed; Region: PRK08939 886882012177 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 886882012178 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882012179 Walker A motif; other site 886882012180 ATP binding site [chemical binding]; other site 886882012181 Walker B motif; other site 886882012182 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 886882012183 putative heme peroxidase; Provisional; Region: PRK12276 886882012184 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 886882012185 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 886882012186 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 886882012187 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 886882012188 Outer membrane efflux protein; Region: OEP; pfam02321 886882012189 HlyD family secretion protein; Region: HlyD_3; pfam13437 886882012190 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882012191 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882012192 putative DNA binding site [nucleotide binding]; other site 886882012193 putative Zn2+ binding site [ion binding]; other site 886882012194 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 886882012195 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882012196 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 886882012197 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 886882012198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882012199 Sporulation inhibitor A; Region: Sda; pfam08970 886882012200 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 886882012201 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 886882012202 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 886882012203 polyphosphate kinase; Provisional; Region: PRK05443 886882012204 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 886882012205 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 886882012206 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 886882012207 putative domain interface [polypeptide binding]; other site 886882012208 putative active site [active] 886882012209 catalytic site [active] 886882012210 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 886882012211 putative domain interface [polypeptide binding]; other site 886882012212 putative active site [active] 886882012213 catalytic site [active] 886882012214 hypothetical protein; Provisional; Region: PRK08236 886882012215 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 886882012216 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 886882012217 Adenylation domain of proteins similar to ATP-dependent polynucleotide ligases; Region: Adenylation_DNA_ligase_like; cl12015 886882012218 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 886882012219 EamA-like transporter family; Region: EamA; pfam00892 886882012220 EamA-like transporter family; Region: EamA; pfam00892 886882012221 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882012222 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882012223 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882012224 dimerization interface [polypeptide binding]; other site 886882012225 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 886882012226 S-layer homology domain; Region: SLH; pfam00395 886882012227 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 886882012228 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 886882012229 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882012230 FeS/SAM binding site; other site 886882012231 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 886882012232 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882012233 hypothetical protein; Provisional; Region: PRK13669 886882012234 NifU-like domain; Region: NifU; cl00484 886882012235 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825 886882012236 classical (c) SDRs; Region: SDR_c; cd05233 886882012237 NAD(P) binding site [chemical binding]; other site 886882012238 active site 886882012239 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 886882012240 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 886882012241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882012242 dimer interface [polypeptide binding]; other site 886882012243 conserved gate region; other site 886882012244 ABC-ATPase subunit interface; other site 886882012245 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 886882012246 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 886882012247 Walker A/P-loop; other site 886882012248 ATP binding site [chemical binding]; other site 886882012249 Q-loop/lid; other site 886882012250 ABC transporter signature motif; other site 886882012251 Walker B; other site 886882012252 D-loop; other site 886882012253 H-loop/switch region; other site 886882012254 NIL domain; Region: NIL; pfam09383 886882012255 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 886882012256 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 886882012257 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 886882012258 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 886882012259 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 886882012260 catalytic residues [active] 886882012261 Protein of unknown function (DUF2515); Region: DUF2515; pfam10720 886882012262 stage V sporulation protein B; Region: spore_V_B; TIGR02900 886882012263 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 886882012264 Protein of unknown function (DUF456); Region: DUF456; pfam04306 886882012265 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 886882012266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882012267 active site 886882012268 motif I; other site 886882012269 motif II; other site 886882012270 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 886882012271 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 886882012272 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 886882012273 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 886882012274 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 886882012275 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 886882012276 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 886882012277 Colicin V production protein; Region: Colicin_V; pfam02674 886882012278 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 886882012279 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 886882012280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882012281 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882012282 putative substrate translocation pore; other site 886882012283 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 886882012284 active site 886882012285 metal binding site [ion binding]; metal-binding site 886882012286 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 886882012287 UbiA prenyltransferase family; Region: UbiA; pfam01040 886882012288 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 886882012289 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 886882012290 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 886882012291 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 886882012292 active site 886882012293 HIGH motif; other site 886882012294 dimer interface [polypeptide binding]; other site 886882012295 KMSKS motif; other site 886882012296 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 886882012297 active site 886882012298 catalytic residues [active] 886882012299 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 886882012300 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 886882012301 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_2; cd09607 886882012302 active site 886882012303 Zn binding site [ion binding]; other site 886882012304 YycC-like protein; Region: YycC; pfam14174 886882012305 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655 886882012306 Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986 886882012307 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 886882012308 apolar tunnel; other site 886882012309 heme binding site [chemical binding]; other site 886882012310 dimerization interface [polypeptide binding]; other site 886882012311 sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871 886882012312 Nucleoside recognition; Region: Gate; pfam07670 886882012313 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 886882012314 ATP-NAD kinase; Region: NAD_kinase; pfam01513 886882012315 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 886882012316 lipoyl synthase; Provisional; Region: PRK05481 886882012317 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882012318 FeS/SAM binding site; other site 886882012319 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 886882012320 Peptidase family M23; Region: Peptidase_M23; pfam01551 886882012321 Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783 886882012322 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 886882012323 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 886882012324 active site 886882012325 catalytic tetrad [active] 886882012326 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882012327 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882012328 dimer interface [polypeptide binding]; other site 886882012329 conserved gate region; other site 886882012330 putative PBP binding loops; other site 886882012331 ABC-ATPase subunit interface; other site 886882012332 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 886882012333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882012334 dimer interface [polypeptide binding]; other site 886882012335 conserved gate region; other site 886882012336 putative PBP binding loops; other site 886882012337 ABC-ATPase subunit interface; other site 886882012338 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882012339 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882012340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882012341 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882012342 dimerization interface [polypeptide binding]; other site 886882012343 Histidine kinase; Region: His_kinase; pfam06580 886882012344 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882012345 ATP binding site [chemical binding]; other site 886882012346 Mg2+ binding site [ion binding]; other site 886882012347 G-X-G motif; other site 886882012348 Response regulator receiver domain; Region: Response_reg; pfam00072 886882012349 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882012350 active site 886882012351 phosphorylation site [posttranslational modification] 886882012352 intermolecular recognition site; other site 886882012353 dimerization interface [polypeptide binding]; other site 886882012354 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882012355 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882012356 A new structural DNA glycosylase; Region: AlkD_like; cd06561 886882012357 active site 886882012358 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 886882012359 endonuclease III; Region: ENDO3c; smart00478 886882012360 minor groove reading motif; other site 886882012361 helix-hairpin-helix signature motif; other site 886882012362 substrate binding pocket [chemical binding]; other site 886882012363 active site 886882012364 Radical SAM superfamily; Region: Radical_SAM; pfam04055 886882012365 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882012366 FeS/SAM binding site; other site 886882012367 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 886882012368 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 886882012369 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 886882012370 DNA binding site [nucleotide binding] 886882012371 active site 886882012372 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 886882012373 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 886882012374 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882012375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882012376 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 886882012377 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 886882012378 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 886882012379 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 886882012380 active site turn [active] 886882012381 phosphorylation site [posttranslational modification] 886882012382 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 886882012383 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 886882012384 HPr interaction site; other site 886882012385 glycerol kinase (GK) interaction site [polypeptide binding]; other site 886882012386 active site 886882012387 phosphorylation site [posttranslational modification] 886882012388 transcriptional antiterminator BglG; Provisional; Region: PRK09772 886882012389 CAT RNA binding domain; Region: CAT_RBD; smart01061 886882012390 PRD domain; Region: PRD; pfam00874 886882012391 PRD domain; Region: PRD; pfam00874 886882012392 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 886882012393 beta-galactosidase; Region: BGL; TIGR03356 886882012394 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 886882012395 hexamer (dimer of trimers) interface [polypeptide binding]; other site 886882012396 substrate binding site [chemical binding]; other site 886882012397 trimer interface [polypeptide binding]; other site 886882012398 Mn binding site [ion binding]; other site 886882012399 transketolase; Reviewed; Region: PRK05899 886882012400 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 886882012401 TPP-binding site [chemical binding]; other site 886882012402 dimer interface [polypeptide binding]; other site 886882012403 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 886882012404 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 886882012405 PYR/PP interface [polypeptide binding]; other site 886882012406 dimer interface [polypeptide binding]; other site 886882012407 TPP binding site [chemical binding]; other site 886882012408 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 886882012409 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 886882012410 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 886882012411 N- and C-terminal domain interface [polypeptide binding]; other site 886882012412 active site 886882012413 MgATP binding site [chemical binding]; other site 886882012414 catalytic site [active] 886882012415 metal binding site [ion binding]; metal-binding site 886882012416 glycerol binding site [chemical binding]; other site 886882012417 homotetramer interface [polypeptide binding]; other site 886882012418 homodimer interface [polypeptide binding]; other site 886882012419 FBP binding site [chemical binding]; other site 886882012420 protein IIAGlc interface [polypeptide binding]; other site 886882012421 HTH domain; Region: HTH_11; pfam08279 886882012422 Mga helix-turn-helix domain; Region: Mga; pfam05043 886882012423 transcriptional antiterminator BglG; Provisional; Region: PRK09772 886882012424 PRD domain; Region: PRD; pfam00874 886882012425 PRD domain; Region: PRD; pfam00874 886882012426 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 886882012427 active site 886882012428 P-loop; other site 886882012429 phosphorylation site [posttranslational modification] 886882012430 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 886882012431 active site 886882012432 phosphorylation site [posttranslational modification] 886882012433 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 886882012434 methionine cluster; other site 886882012435 active site 886882012436 phosphorylation site [posttranslational modification] 886882012437 metal binding site [ion binding]; metal-binding site 886882012438 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 886882012439 active site 886882012440 P-loop; other site 886882012441 phosphorylation site [posttranslational modification] 886882012442 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 886882012443 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 886882012444 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 886882012445 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 886882012446 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882012447 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882012448 DNA binding residues [nucleotide binding] 886882012449 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 886882012450 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 886882012451 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 886882012452 FtsX-like permease family; Region: FtsX; pfam02687 886882012453 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 886882012454 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 886882012455 Walker A/P-loop; other site 886882012456 ATP binding site [chemical binding]; other site 886882012457 Q-loop/lid; other site 886882012458 ABC transporter signature motif; other site 886882012459 Walker B; other site 886882012460 D-loop; other site 886882012461 H-loop/switch region; other site 886882012462 HlyD family secretion protein; Region: HlyD_2; pfam12700 886882012463 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 886882012464 HlyD family secretion protein; Region: HlyD_3; pfam13437 886882012465 putative membrane fusion protein; Region: TIGR02828 886882012466 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 886882012467 FtsX-like permease family; Region: FtsX; pfam02687 886882012468 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 886882012469 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 886882012470 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 886882012471 Walker A/P-loop; other site 886882012472 ATP binding site [chemical binding]; other site 886882012473 Q-loop/lid; other site 886882012474 ABC transporter signature motif; other site 886882012475 Walker B; other site 886882012476 D-loop; other site 886882012477 H-loop/switch region; other site 886882012478 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882012479 His Kinase A (phosphoacceptor) domain; Region: HisKA; smart00388 886882012480 dimer interface [polypeptide binding]; other site 886882012481 phosphorylation site [posttranslational modification] 886882012482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882012483 ATP binding site [chemical binding]; other site 886882012484 Mg2+ binding site [ion binding]; other site 886882012485 G-X-G motif; other site 886882012486 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882012487 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882012488 active site 886882012489 phosphorylation site [posttranslational modification] 886882012490 intermolecular recognition site; other site 886882012491 dimerization interface [polypeptide binding]; other site 886882012492 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882012493 DNA binding site [nucleotide binding] 886882012494 Helix-turn-helix domain; Region: HTH_18; pfam12833 886882012495 RNA polymerase sigma factor; Provisional; Region: PRK12543 886882012496 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882012497 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882012498 DNA binding residues [nucleotide binding] 886882012499 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 886882012500 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 886882012501 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 886882012502 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 886882012503 TrkA-N domain; Region: TrkA_N; pfam02254 886882012504 TrkA-C domain; Region: TrkA_C; pfam02080 886882012505 Small, acid-soluble spore protein I; Region: SSPI; cl07940 886882012506 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 886882012507 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 886882012508 G1 box; other site 886882012509 putative GEF interaction site [polypeptide binding]; other site 886882012510 GTP/Mg2+ binding site [chemical binding]; other site 886882012511 Switch I region; other site 886882012512 G2 box; other site 886882012513 G3 box; other site 886882012514 Switch II region; other site 886882012515 G4 box; other site 886882012516 G5 box; other site 886882012517 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 886882012518 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 886882012519 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 886882012520 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 886882012521 Protein of unknown function (DUF1779); Region: DUF1779; pfam08680 886882012522 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 886882012523 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882012524 active site 886882012525 phosphorylation site [posttranslational modification] 886882012526 intermolecular recognition site; other site 886882012527 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 886882012528 DNA binding residues [nucleotide binding] 886882012529 dimerization interface [polypeptide binding]; other site 886882012530 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 886882012531 Histidine kinase; Region: HisKA_3; pfam07730 886882012532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882012533 ATP binding site [chemical binding]; other site 886882012534 Mg2+ binding site [ion binding]; other site 886882012535 G-X-G motif; other site 886882012536 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 886882012537 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 886882012538 PspC domain; Region: PspC; pfam04024 886882012539 PspA/IM30 family; Region: PspA_IM30; pfam04012 886882012540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882012541 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882012542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882012543 putative substrate translocation pore; other site 886882012544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882012545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882012546 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 886882012547 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 886882012548 FeS assembly protein SufB; Region: sufB; TIGR01980 886882012549 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 886882012550 FeS assembly protein SufD; Region: sufD; TIGR01981 886882012551 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 886882012552 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 886882012553 Walker A/P-loop; other site 886882012554 ATP binding site [chemical binding]; other site 886882012555 Q-loop/lid; other site 886882012556 ABC transporter signature motif; other site 886882012557 Walker B; other site 886882012558 D-loop; other site 886882012559 H-loop/switch region; other site 886882012560 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882012561 MarR family; Region: MarR; pfam01047 886882012562 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 886882012563 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882012564 Bacterial SH3 domain homologues; Region: SH3b; smart00287 886882012565 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 886882012566 active site 886882012567 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 886882012568 metal binding site 2 [ion binding]; metal-binding site 886882012569 putative DNA binding helix; other site 886882012570 metal binding site 1 [ion binding]; metal-binding site 886882012571 dimer interface [polypeptide binding]; other site 886882012572 structural Zn2+ binding site [ion binding]; other site 886882012573 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 886882012574 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 886882012575 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 886882012576 MgtC family; Region: MgtC; pfam02308 886882012577 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 886882012578 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882012579 Coenzyme A binding pocket [chemical binding]; other site 886882012580 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 886882012581 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 886882012582 GatB domain; Region: GatB_Yqey; smart00845 886882012583 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 886882012584 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 886882012585 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 886882012586 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 886882012587 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 886882012588 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 886882012589 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 886882012590 Methyltransferase domain; Region: Methyltransf_31; pfam13847 886882012591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882012592 S-adenosylmethionine binding site [chemical binding]; other site 886882012593 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 886882012594 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 886882012595 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 886882012596 Protein of unknown function (DUF1256); Region: DUF1256; cl06087 886882012597 Protein of unknown function (DUF1128); Region: DUF1128; cl11553 886882012598 Pirin-related protein [General function prediction only]; Region: COG1741 886882012599 Pirin; Region: Pirin; pfam02678 886882012600 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 886882012601 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 886882012602 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 886882012603 active site 886882012604 Escherichia coli CorA-Salmonella typhimurium ZntB_like family; Region: EcCorA_ZntB-like; cd12821 886882012605 Cl binding site [ion binding]; other site 886882012606 oligomer interface [polypeptide binding]; other site 886882012607 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 886882012608 RNA polymerase sigma factor SigB; Validated; Region: PRK08583 886882012609 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882012610 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 886882012611 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 886882012612 DNA binding residues [nucleotide binding] 886882012613 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 886882012614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882012615 ATP binding site [chemical binding]; other site 886882012616 Mg2+ binding site [ion binding]; other site 886882012617 G-X-G motif; other site 886882012618 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 886882012619 anti sigma factor interaction site; other site 886882012620 regulatory phosphorylation site [posttranslational modification]; other site 886882012621 Response regulator receiver domain; Region: Response_reg; pfam00072 886882012622 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882012623 active site 886882012624 phosphorylation site [posttranslational modification] 886882012625 intermolecular recognition site; other site 886882012626 dimerization interface [polypeptide binding]; other site 886882012627 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882012628 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882012629 dimer interface [polypeptide binding]; other site 886882012630 phosphorylation site [posttranslational modification] 886882012631 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882012632 ATP binding site [chemical binding]; other site 886882012633 Mg2+ binding site [ion binding]; other site 886882012634 G-X-G motif; other site 886882012635 Response regulator receiver domain; Region: Response_reg; pfam00072 886882012636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882012637 active site 886882012638 phosphorylation site [posttranslational modification] 886882012639 intermolecular recognition site; other site 886882012640 dimerization interface [polypeptide binding]; other site 886882012641 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 886882012642 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 886882012643 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 886882012644 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 886882012645 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 886882012646 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 886882012647 GAF domain; Region: GAF_3; pfam13492 886882012648 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882012649 dimer interface [polypeptide binding]; other site 886882012650 phosphorylation site [posttranslational modification] 886882012651 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882012652 ATP binding site [chemical binding]; other site 886882012653 Mg2+ binding site [ion binding]; other site 886882012654 G-X-G motif; other site 886882012655 Response regulator receiver domain; Region: Response_reg; pfam00072 886882012656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882012657 active site 886882012658 phosphorylation site [posttranslational modification] 886882012659 intermolecular recognition site; other site 886882012660 dimerization interface [polypeptide binding]; other site 886882012661 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 886882012662 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882012663 active site 886882012664 phosphorylation site [posttranslational modification] 886882012665 intermolecular recognition site; other site 886882012666 dimerization interface [polypeptide binding]; other site 886882012667 Response regulator receiver domain; Region: Response_reg; pfam00072 886882012668 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882012669 active site 886882012670 phosphorylation site [posttranslational modification] 886882012671 intermolecular recognition site; other site 886882012672 dimerization interface [polypeptide binding]; other site 886882012673 Response regulator receiver domain; Region: Response_reg; pfam00072 886882012674 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882012675 active site 886882012676 phosphorylation site [posttranslational modification] 886882012677 intermolecular recognition site; other site 886882012678 dimerization interface [polypeptide binding]; other site 886882012679 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 886882012680 Heat induced stress protein YflT; Region: YflT; pfam11181 886882012681 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 886882012682 Bacterial SH3 domain; Region: SH3_3; pfam08239 886882012683 Bacterial SH3 domain; Region: SH3_3; pfam08239 886882012684 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 886882012685 NlpC/P60 family; Region: NLPC_P60; pfam00877 886882012686 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 886882012687 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 886882012688 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 886882012689 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 886882012690 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 886882012691 ABC transporter; Region: ABC_tran_2; pfam12848 886882012692 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 886882012693 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 886882012694 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 886882012695 Walker A/P-loop; other site 886882012696 ATP binding site [chemical binding]; other site 886882012697 Q-loop/lid; other site 886882012698 ABC transporter signature motif; other site 886882012699 Walker B; other site 886882012700 D-loop; other site 886882012701 H-loop/switch region; other site 886882012702 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 886882012703 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882012704 dimer interface [polypeptide binding]; other site 886882012705 ABC-ATPase subunit interface; other site 886882012706 putative PBP binding regions; other site 886882012707 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 886882012708 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 886882012709 intersubunit interface [polypeptide binding]; other site 886882012710 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cl02760 886882012711 heme-binding site [chemical binding]; other site 886882012712 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 886882012713 heme-binding site [chemical binding]; other site 886882012714 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 886882012715 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 886882012716 heme-binding site [chemical binding]; other site 886882012717 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 886882012718 heme-binding site [chemical binding]; other site 886882012719 Cell surface protein [Cell envelope biogenesis, outer membrane]; Region: COG5386 886882012720 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 886882012721 heme-binding site [chemical binding]; other site 886882012722 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 886882012723 heme-binding site [chemical binding]; other site 886882012724 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 886882012725 heme-binding site [chemical binding]; other site 886882012726 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 886882012727 heme-binding site [chemical binding]; other site 886882012728 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 886882012729 heme-binding site [chemical binding]; other site 886882012730 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 886882012731 heme-binding site [chemical binding]; other site 886882012732 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 886882012733 heme-binding site [chemical binding]; other site 886882012734 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 886882012735 heme-binding site [chemical binding]; other site 886882012736 NEAr Transport domain, a component of cell surface proteins; Region: NEAT; cd06920 886882012737 heme-binding site [chemical binding]; other site 886882012738 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 886882012739 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 886882012740 intersubunit interface [polypeptide binding]; other site 886882012741 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 886882012742 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882012743 ABC-ATPase subunit interface; other site 886882012744 dimer interface [polypeptide binding]; other site 886882012745 putative PBP binding regions; other site 886882012746 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 886882012747 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 886882012748 Walker A/P-loop; other site 886882012749 ATP binding site [chemical binding]; other site 886882012750 Q-loop/lid; other site 886882012751 ABC transporter signature motif; other site 886882012752 Walker B; other site 886882012753 D-loop; other site 886882012754 H-loop/switch region; other site 886882012755 heme-degrading monooxygenase IsdG; Provisional; Region: PRK13314 886882012756 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 886882012757 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 886882012758 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 886882012759 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 886882012760 MarR family; Region: MarR_2; cl17246 886882012761 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 886882012762 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882012763 putative substrate translocation pore; other site 886882012764 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; smart00932 886882012765 Virulence factor; Region: Virulence_fact; pfam13769 886882012766 HEAT repeats; Region: HEAT_2; pfam13646 886882012767 HEAT repeats; Region: HEAT_2; pfam13646 886882012768 E-Z type HEAT repeats; Region: EZ_HEAT; smart00567 886882012769 lysine transporter; Provisional; Region: PRK10836 886882012770 H+ Antiporter protein; Region: 2A0121; TIGR00900 886882012771 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 886882012772 FeoA domain; Region: FeoA; cl00838 886882012773 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 886882012774 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 886882012775 G1 box; other site 886882012776 GTP/Mg2+ binding site [chemical binding]; other site 886882012777 Switch I region; other site 886882012778 G2 box; other site 886882012779 G3 box; other site 886882012780 Switch II region; other site 886882012781 G4 box; other site 886882012782 G5 box; other site 886882012783 Nucleoside recognition; Region: Gate; pfam07670 886882012784 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 886882012785 Nucleoside recognition; Region: Gate; pfam07670 886882012786 Virus attachment protein p12 family; Region: P12; pfam12669 886882012787 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 886882012788 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 886882012789 Walker A/P-loop; other site 886882012790 ATP binding site [chemical binding]; other site 886882012791 Q-loop/lid; other site 886882012792 ABC transporter signature motif; other site 886882012793 Walker B; other site 886882012794 D-loop; other site 886882012795 H-loop/switch region; other site 886882012796 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 886882012797 Peptidase C39 family; Region: Peptidase_C39; pfam03412 886882012798 putative active site [active] 886882012799 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882012800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882012801 Walker A/P-loop; other site 886882012802 ATP binding site [chemical binding]; other site 886882012803 Q-loop/lid; other site 886882012804 ABC transporter signature motif; other site 886882012805 Walker B; other site 886882012806 D-loop; other site 886882012807 H-loop/switch region; other site 886882012808 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 886882012809 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 886882012810 DNA binding residues [nucleotide binding] 886882012811 dimerization interface [polypeptide binding]; other site 886882012812 type 2 lantibiotic, mersacidin/lichenicidin family; Region: lanti_MRSA_kill; TIGR03898 886882012813 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 886882012814 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 886882012815 active site 886882012816 zinc binding site [ion binding]; other site 886882012817 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 886882012818 N- and C-terminal domain interface [polypeptide binding]; other site 886882012819 D-xylulose kinase; Region: XylB; TIGR01312 886882012820 active site 886882012821 MgATP binding site [chemical binding]; other site 886882012822 catalytic site [active] 886882012823 metal binding site [ion binding]; metal-binding site 886882012824 xylulose binding site [chemical binding]; other site 886882012825 homodimer interface [polypeptide binding]; other site 886882012826 xylose isomerase; Provisional; Region: PRK05474 886882012827 xylose isomerase; Region: xylose_isom_A; TIGR02630 886882012828 MarR family; Region: MarR_2; pfam12802 886882012829 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 886882012830 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 886882012831 nucleotide binding site [chemical binding]; other site 886882012832 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 886882012833 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 886882012834 catalytic residues [active] 886882012835 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 886882012836 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 886882012837 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882012838 ZIP Zinc transporter; Region: Zip; pfam02535 886882012839 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428 886882012840 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 886882012841 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 886882012842 HlyD family secretion protein; Region: HlyD_3; pfam13437 886882012843 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 886882012844 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882012845 putative substrate translocation pore; other site 886882012846 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 886882012847 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 886882012848 Soluble P-type ATPase [General function prediction only]; Region: COG4087 886882012849 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 886882012850 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 886882012851 metal-binding site [ion binding] 886882012852 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 886882012853 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 886882012854 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 886882012855 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882012856 dimerization interface [polypeptide binding]; other site 886882012857 putative DNA binding site [nucleotide binding]; other site 886882012858 putative Zn2+ binding site [ion binding]; other site 886882012859 Old yellow enzyme (OYE)-related FMN binding domain, group 5. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_5_FMN; cd04747 886882012860 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 886882012861 putative active site [active] 886882012862 putative FMN binding site [chemical binding]; other site 886882012863 putative substrate binding site [chemical binding]; other site 886882012864 putative catalytic residue [active] 886882012865 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204 886882012866 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 886882012867 Subunit I/III interface [polypeptide binding]; other site 886882012868 Subunit III/IV interface [polypeptide binding]; other site 886882012869 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 886882012870 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 886882012871 D-pathway; other site 886882012872 Putative ubiquinol binding site [chemical binding]; other site 886882012873 Low-spin heme (heme b) binding site [chemical binding]; other site 886882012874 Putative water exit pathway; other site 886882012875 Binuclear center (heme o3/CuB) [ion binding]; other site 886882012876 K-pathway; other site 886882012877 Putative proton exit pathway; other site 886882012878 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 886882012879 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 886882012880 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 886882012881 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 886882012882 beta-galactosidase; Region: BGL; TIGR03356 886882012883 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882012884 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882012885 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882012886 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882012887 dimer interface [polypeptide binding]; other site 886882012888 ABC-ATPase subunit interface; other site 886882012889 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882012890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882012891 dimer interface [polypeptide binding]; other site 886882012892 conserved gate region; other site 886882012893 putative PBP binding loops; other site 886882012894 ABC-ATPase subunit interface; other site 886882012895 NnrS protein; Region: NnrS; cl01258 886882012896 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 886882012897 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 886882012898 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882012899 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 886882012900 Walker A/P-loop; other site 886882012901 ATP binding site [chemical binding]; other site 886882012902 Q-loop/lid; other site 886882012903 ABC transporter signature motif; other site 886882012904 Walker B; other site 886882012905 D-loop; other site 886882012906 H-loop/switch region; other site 886882012907 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 886882012908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882012909 Walker A/P-loop; other site 886882012910 ATP binding site [chemical binding]; other site 886882012911 Q-loop/lid; other site 886882012912 ABC transporter signature motif; other site 886882012913 Walker B; other site 886882012914 D-loop; other site 886882012915 H-loop/switch region; other site 886882012916 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 886882012917 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 886882012918 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 886882012919 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 886882012920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882012921 Response regulator receiver domain; Region: Response_reg; pfam00072 886882012922 active site 886882012923 phosphorylation site [posttranslational modification] 886882012924 intermolecular recognition site; other site 886882012925 dimerization interface [polypeptide binding]; other site 886882012926 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882012927 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882012928 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 886882012929 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882012930 dimerization interface [polypeptide binding]; other site 886882012931 Histidine kinase; Region: His_kinase; pfam06580 886882012932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882012933 ATP binding site [chemical binding]; other site 886882012934 Mg2+ binding site [ion binding]; other site 886882012935 G-X-G motif; other site 886882012936 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 886882012937 active site 886882012938 catalytic residues [active] 886882012939 metal binding site [ion binding]; metal-binding site 886882012940 Exopolysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: COG5039 886882012941 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 886882012942 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 886882012943 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 886882012944 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 886882012945 active site 886882012946 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 886882012947 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 886882012948 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 886882012949 active site 886882012950 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 886882012951 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 886882012952 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 886882012953 Domain of unknown function DUF21; Region: DUF21; pfam01595 886882012954 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 886882012955 Transporter associated domain; Region: CorC_HlyC; pfam03471 886882012956 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 886882012957 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 886882012958 catalytic residues [active] 886882012959 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 886882012960 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 886882012961 active site 886882012962 catalytic tetrad [active] 886882012963 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 886882012964 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 886882012965 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 886882012966 putative ligand binding residues [chemical binding]; other site 886882012967 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 886882012968 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 886882012969 Walker A/P-loop; other site 886882012970 ATP binding site [chemical binding]; other site 886882012971 Q-loop/lid; other site 886882012972 ABC transporter signature motif; other site 886882012973 Walker B; other site 886882012974 D-loop; other site 886882012975 H-loop/switch region; other site 886882012976 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882012977 ABC-ATPase subunit interface; other site 886882012978 dimer interface [polypeptide binding]; other site 886882012979 putative PBP binding regions; other site 886882012980 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 886882012981 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 886882012982 ABC-ATPase subunit interface; other site 886882012983 dimer interface [polypeptide binding]; other site 886882012984 putative PBP binding regions; other site 886882012985 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882012986 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882012987 active site 886882012988 phosphorylation site [posttranslational modification] 886882012989 intermolecular recognition site; other site 886882012990 dimerization interface [polypeptide binding]; other site 886882012991 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882012992 DNA binding site [nucleotide binding] 886882012993 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882012994 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 886882012995 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882012996 ATP binding site [chemical binding]; other site 886882012997 Mg2+ binding site [ion binding]; other site 886882012998 G-X-G motif; other site 886882012999 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 886882013000 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 886882013001 Walker A/P-loop; other site 886882013002 ATP binding site [chemical binding]; other site 886882013003 Q-loop/lid; other site 886882013004 ABC transporter signature motif; other site 886882013005 Walker B; other site 886882013006 D-loop; other site 886882013007 H-loop/switch region; other site 886882013008 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 886882013009 FtsX-like permease family; Region: FtsX; pfam02687 886882013010 FtsX-like permease family; Region: FtsX; pfam02687 886882013011 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882013012 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882013013 dimer interface [polypeptide binding]; other site 886882013014 phosphorylation site [posttranslational modification] 886882013015 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 886882013016 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 886882013017 Walker A/P-loop; other site 886882013018 ATP binding site [chemical binding]; other site 886882013019 Q-loop/lid; other site 886882013020 ABC transporter signature motif; other site 886882013021 Walker B; other site 886882013022 D-loop; other site 886882013023 H-loop/switch region; other site 886882013024 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 886882013025 FtsX-like permease family; Region: FtsX; pfam02687 886882013026 FtsX-like permease family; Region: FtsX; pfam02687 886882013027 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882013028 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 886882013029 FeS/SAM binding site; other site 886882013030 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 886882013031 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 886882013032 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882013033 FeS/SAM binding site; other site 886882013034 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 886882013035 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882013036 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882013037 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 886882013038 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 886882013039 Walker A/P-loop; other site 886882013040 ATP binding site [chemical binding]; other site 886882013041 Q-loop/lid; other site 886882013042 ABC transporter signature motif; other site 886882013043 Walker B; other site 886882013044 D-loop; other site 886882013045 H-loop/switch region; other site 886882013046 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882013047 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882013048 ATP binding site [chemical binding]; other site 886882013049 Mg2+ binding site [ion binding]; other site 886882013050 G-X-G motif; other site 886882013051 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 886882013052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882013053 active site 886882013054 phosphorylation site [posttranslational modification] 886882013055 intermolecular recognition site; other site 886882013056 dimerization interface [polypeptide binding]; other site 886882013057 LytTr DNA-binding domain; Region: LytTR; smart00850 886882013058 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 886882013059 active site 886882013060 catalytic residues [active] 886882013061 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 886882013062 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 886882013063 catalytic residues [active] 886882013064 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 886882013065 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 886882013066 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 886882013067 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 886882013068 Zn binding site [ion binding]; other site 886882013069 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 886882013070 Zn binding site [ion binding]; other site 886882013071 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 886882013072 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 886882013073 active site 886882013074 Zn binding site [ion binding]; other site 886882013075 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 886882013076 dimer interface [polypeptide binding]; other site 886882013077 substrate binding site [chemical binding]; other site 886882013078 ATP binding site [chemical binding]; other site 886882013079 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 886882013080 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 886882013081 active site 886882013082 metal binding site [ion binding]; metal-binding site 886882013083 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 886882013084 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 886882013085 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 886882013086 membrane-bound complex binding site; other site 886882013087 hinge residues; other site 886882013088 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 886882013089 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 886882013090 Walker A/P-loop; other site 886882013091 ATP binding site [chemical binding]; other site 886882013092 Q-loop/lid; other site 886882013093 ABC transporter signature motif; other site 886882013094 Walker B; other site 886882013095 D-loop; other site 886882013096 H-loop/switch region; other site 886882013097 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 886882013098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882013099 dimer interface [polypeptide binding]; other site 886882013100 conserved gate region; other site 886882013101 ABC-ATPase subunit interface; other site 886882013102 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 886882013103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882013104 dimer interface [polypeptide binding]; other site 886882013105 conserved gate region; other site 886882013106 putative PBP binding loops; other site 886882013107 ABC-ATPase subunit interface; other site 886882013108 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 886882013109 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 886882013110 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 886882013111 catalytic residue [active] 886882013112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882013113 dimer interface [polypeptide binding]; other site 886882013114 conserved gate region; other site 886882013115 putative PBP binding loops; other site 886882013116 ABC-ATPase subunit interface; other site 886882013117 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 886882013118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882013119 dimer interface [polypeptide binding]; other site 886882013120 conserved gate region; other site 886882013121 putative PBP binding loops; other site 886882013122 ABC-ATPase subunit interface; other site 886882013123 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 886882013124 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 886882013125 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 886882013126 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 886882013127 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 886882013128 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 886882013129 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 886882013130 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 886882013131 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 886882013132 phosphopentomutase; Provisional; Region: PRK05362 886882013133 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 886882013134 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 886882013135 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 886882013136 Nucleoside recognition; Region: Gate; pfam07670 886882013137 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 886882013138 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 886882013139 active site 886882013140 catalytic motif [active] 886882013141 Zn binding site [ion binding]; other site 886882013142 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 886882013143 intersubunit interface [polypeptide binding]; other site 886882013144 active site 886882013145 catalytic residue [active] 886882013146 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 886882013147 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882013148 DNA binding residues [nucleotide binding] 886882013149 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 886882013150 CheW-like domain; Region: CheW; pfam01584 886882013151 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 886882013152 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 886882013153 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882013154 S-adenosylmethionine binding site [chemical binding]; other site 886882013155 Methyltransferase domain; Region: Methyltransf_23; pfam13489 886882013156 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 886882013157 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882013158 Interdomain contacts; other site 886882013159 Cytokine receptor motif; other site 886882013160 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 886882013161 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 886882013162 catalytic motif [active] 886882013163 Zn binding site [ion binding]; other site 886882013164 RibD C-terminal domain; Region: RibD_C; cl17279 886882013165 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 886882013166 dimerization interface [polypeptide binding]; other site 886882013167 active site 886882013168 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 886882013169 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 886882013170 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882013171 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 886882013172 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882013173 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 886882013174 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 886882013175 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 886882013176 conserved cys residue [active] 886882013177 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 886882013178 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 886882013179 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 886882013180 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 886882013181 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 886882013182 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882013183 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 886882013184 Low molecular weight phosphatase family; Region: LMWPc; cl00105 886882013185 arsenical pump membrane protein; Provisional; Region: PRK15445 886882013186 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 886882013187 transmembrane helices; other site 886882013188 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 886882013189 Methyltransferase domain; Region: Methyltransf_11; pfam08241 886882013190 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 886882013191 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882013192 sugar efflux transporter; Region: 2A0120; TIGR00899 886882013193 putative substrate translocation pore; other site 886882013194 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 886882013195 glycosyltransferase, MGT family; Region: MGT; TIGR01426 886882013196 active site 886882013197 TDP-binding site; other site 886882013198 acceptor substrate-binding pocket; other site 886882013199 homodimer interface [polypeptide binding]; other site 886882013200 Pectate lyase; Region: Pec_lyase_C; cl01593 886882013201 putative pectinesterase; Region: PLN02432; cl01911 886882013202 Pectinesterase; Region: Pectinesterase; pfam01095 886882013203 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882013204 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 886882013205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882013206 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882013207 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 886882013208 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 886882013209 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 886882013210 catalytic residue [active] 886882013211 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882013212 MarR family; Region: MarR_2; cl17246 886882013213 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 886882013214 Cation efflux family; Region: Cation_efflux; cl00316 886882013215 HlyD family secretion protein; Region: HlyD_2; pfam12700 886882013216 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 886882013217 HlyD family secretion protein; Region: HlyD_3; pfam13437 886882013218 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 886882013219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882013220 active site 886882013221 phosphorylation site [posttranslational modification] 886882013222 intermolecular recognition site; other site 886882013223 dimerization interface [polypeptide binding]; other site 886882013224 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 886882013225 DNA binding residues [nucleotide binding] 886882013226 dimerization interface [polypeptide binding]; other site 886882013227 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 886882013228 Histidine kinase; Region: HisKA_3; pfam07730 886882013229 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882013230 ATP binding site [chemical binding]; other site 886882013231 Mg2+ binding site [ion binding]; other site 886882013232 G-X-G motif; other site 886882013233 Small acid-soluble spore protein H family; Region: SspH; pfam08141 886882013234 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 886882013235 glycosyltransferase, MGT family; Region: MGT; TIGR01426 886882013236 active site 886882013237 TDP-binding site; other site 886882013238 acceptor substrate-binding pocket; other site 886882013239 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 886882013240 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 886882013241 substrate binding [chemical binding]; other site 886882013242 active site 886882013243 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 886882013244 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882013245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882013246 dimer interface [polypeptide binding]; other site 886882013247 conserved gate region; other site 886882013248 putative PBP binding loops; other site 886882013249 ABC-ATPase subunit interface; other site 886882013250 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882013251 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882013252 dimer interface [polypeptide binding]; other site 886882013253 conserved gate region; other site 886882013254 putative PBP binding loops; other site 886882013255 ABC-ATPase subunit interface; other site 886882013256 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882013257 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882013258 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882013259 DNA binding site [nucleotide binding] 886882013260 domain linker motif; other site 886882013261 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 886882013262 dimerization interface [polypeptide binding]; other site 886882013263 ligand binding site [chemical binding]; other site 886882013264 sodium binding site [ion binding]; other site 886882013265 Glycosyl hydrolases family 11; Region: Glyco_hydro_11; pfam00457 886882013266 Condensation domain; Region: Condensation; pfam00668 886882013267 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882013268 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 886882013269 acyl-activating enzyme (AAE) consensus motif; other site 886882013270 AMP binding site [chemical binding]; other site 886882013271 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882013272 peptide synthase; Provisional; Region: PRK12467 886882013273 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882013274 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882013275 acyl-activating enzyme (AAE) consensus motif; other site 886882013276 AMP binding site [chemical binding]; other site 886882013277 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882013278 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 886882013279 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 886882013280 acyl-activating enzyme (AAE) consensus motif; other site 886882013281 AMP binding site [chemical binding]; other site 886882013282 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882013283 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882013284 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 886882013285 acyl-activating enzyme (AAE) consensus motif; other site 886882013286 AMP binding site [chemical binding]; other site 886882013287 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882013288 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882013289 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 886882013290 Walker A/P-loop; other site 886882013291 ATP binding site [chemical binding]; other site 886882013292 Q-loop/lid; other site 886882013293 ABC transporter signature motif; other site 886882013294 Walker B; other site 886882013295 D-loop; other site 886882013296 H-loop/switch region; other site 886882013297 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 886882013298 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 886882013299 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 886882013300 Walker A/P-loop; other site 886882013301 ATP binding site [chemical binding]; other site 886882013302 Q-loop/lid; other site 886882013303 ABC transporter signature motif; other site 886882013304 Walker B; other site 886882013305 D-loop; other site 886882013306 H-loop/switch region; other site 886882013307 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 886882013308 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 886882013309 acyl-activating enzyme (AAE) consensus motif; other site 886882013310 AMP binding site [chemical binding]; other site 886882013311 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 886882013312 Condensation domain; Region: Condensation; pfam00668 886882013313 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882013314 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 886882013315 Condensation domain; Region: Condensation; pfam00668 886882013316 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 886882013317 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 886882013318 acyl-activating enzyme (AAE) consensus motif; other site 886882013319 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 886882013320 Erythromycin esterase; Region: Erythro_esteras; pfam05139 886882013321 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 886882013322 Beta-lactamase; Region: Beta-lactamase; pfam00144 886882013323 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 886882013324 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 886882013325 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 886882013326 glutaminase active site [active] 886882013327 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 886882013328 dimer interface [polypeptide binding]; other site 886882013329 active site 886882013330 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 886882013331 dimer interface [polypeptide binding]; other site 886882013332 active site 886882013333 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 886882013334 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 886882013335 active site 886882013336 substrate binding site [chemical binding]; other site 886882013337 metal binding site [ion binding]; metal-binding site 886882013338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 886882013339 YbbR-like protein; Region: YbbR; pfam07949 886882013340 Uncharacterized conserved protein [Function unknown]; Region: COG1624 886882013341 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 886882013342 Putative zinc-finger; Region: zf-HC2; pfam13490 886882013343 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 886882013344 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 886882013345 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 886882013346 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882013347 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882013348 DNA binding residues [nucleotide binding] 886882013349 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 886882013350 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 886882013351 potential protein location (hypothetical protein PPSC2_c4732 [Paenibacillus polymyxa SC2]) that overlaps RNA (tRNA-G) 886882013352 Integral membrane protein DUF95; Region: DUF95; pfam01944 886882013353 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 886882013354 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 886882013355 Domain of unknown function DUF59; Region: DUF59; pfam01883 886882013356 cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969 886882013357 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 886882013358 Walker A motif; other site 886882013359 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 886882013360 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 886882013361 active site 886882013362 metal binding site [ion binding]; metal-binding site 886882013363 sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149 886882013364 ATP-sulfurylase; Region: ATPS; cd00517 886882013365 active site 886882013366 HXXH motif; other site 886882013367 flexible loop; other site 886882013368 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 886882013369 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 886882013370 Active Sites [active] 886882013371 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 886882013372 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 886882013373 23S rRNA interface [nucleotide binding]; other site 886882013374 L3 interface [polypeptide binding]; other site 886882013375 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 886882013376 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 886882013377 dimerization interface 3.5A [polypeptide binding]; other site 886882013378 active site 886882013379 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 886882013380 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 886882013381 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 886882013382 alphaNTD - beta interaction site [polypeptide binding]; other site 886882013383 alphaNTD homodimer interface [polypeptide binding]; other site 886882013384 alphaNTD - beta' interaction site [polypeptide binding]; other site 886882013385 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 886882013386 30S ribosomal protein S11; Validated; Region: PRK05309 886882013387 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 886882013388 30S ribosomal protein S13; Region: bact_S13; TIGR03631 886882013389 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 886882013390 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 886882013391 rRNA binding site [nucleotide binding]; other site 886882013392 predicted 30S ribosome binding site; other site 886882013393 KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088 886882013394 RNA binding site [nucleotide binding]; other site 886882013395 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 886882013396 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 886882013397 adenylate kinase; Reviewed; Region: adk; PRK00279 886882013398 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 886882013399 AMP-binding site [chemical binding]; other site 886882013400 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 886882013401 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 886882013402 SecY translocase; Region: SecY; pfam00344 886882013403 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 886882013404 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 886882013405 23S rRNA binding site [nucleotide binding]; other site 886882013406 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 886882013407 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 886882013408 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 886882013409 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 886882013410 5S rRNA interface [nucleotide binding]; other site 886882013411 L27 interface [polypeptide binding]; other site 886882013412 23S rRNA interface [nucleotide binding]; other site 886882013413 L5 interface [polypeptide binding]; other site 886882013414 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 886882013415 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 886882013416 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 886882013417 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 886882013418 Ribosomal protein S14p/S29e; Region: Ribosomal_S14; cl00355 886882013419 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 886882013420 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 886882013421 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 886882013422 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 886882013423 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 886882013424 RNA binding site [nucleotide binding]; other site 886882013425 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 886882013426 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 886882013427 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 886882013428 23S rRNA interface [nucleotide binding]; other site 886882013429 putative translocon interaction site; other site 886882013430 signal recognition particle (SRP54) interaction site; other site 886882013431 L23 interface [polypeptide binding]; other site 886882013432 trigger factor interaction site; other site 886882013433 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 886882013434 23S rRNA interface [nucleotide binding]; other site 886882013435 5S rRNA interface [nucleotide binding]; other site 886882013436 putative antibiotic binding site [chemical binding]; other site 886882013437 L25 interface [polypeptide binding]; other site 886882013438 L27 interface [polypeptide binding]; other site 886882013439 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 886882013440 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 886882013441 G-X-X-G motif; other site 886882013442 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 886882013443 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 886882013444 putative translocon binding site; other site 886882013445 protein-rRNA interface [nucleotide binding]; other site 886882013446 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 886882013447 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 886882013448 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 886882013449 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 886882013450 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 886882013451 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 886882013452 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 886882013453 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 886882013454 elongation factor Tu; Reviewed; Region: PRK00049 886882013455 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 886882013456 G1 box; other site 886882013457 GEF interaction site [polypeptide binding]; other site 886882013458 GTP/Mg2+ binding site [chemical binding]; other site 886882013459 Switch I region; other site 886882013460 G2 box; other site 886882013461 G3 box; other site 886882013462 Switch II region; other site 886882013463 G4 box; other site 886882013464 G5 box; other site 886882013465 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 886882013466 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 886882013467 Antibiotic Binding Site [chemical binding]; other site 886882013468 elongation factor G; Reviewed; Region: PRK00007 886882013469 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 886882013470 Switch I region; other site 886882013471 G2 box; other site 886882013472 putative GEF interaction site [polypeptide binding]; other site 886882013473 G3 box; other site 886882013474 Switch II region; other site 886882013475 GTP/Mg2+ binding site [chemical binding]; other site 886882013476 G4 box; other site 886882013477 G5 box; other site 886882013478 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 886882013479 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 886882013480 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 886882013481 30S ribosomal protein S7; Validated; Region: PRK05302 886882013482 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 886882013483 S17 interaction site [polypeptide binding]; other site 886882013484 S8 interaction site; other site 886882013485 16S rRNA interaction site [nucleotide binding]; other site 886882013486 streptomycin interaction site [chemical binding]; other site 886882013487 23S rRNA interaction site [nucleotide binding]; other site 886882013488 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 886882013489 putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602 886882013490 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 886882013491 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 886882013492 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 886882013493 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 886882013494 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 886882013495 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 886882013496 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 886882013497 G-loop; other site 886882013498 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 886882013499 DNA binding site [nucleotide binding] 886882013500 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 886882013501 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 886882013502 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 886882013503 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 886882013504 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 886882013505 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 886882013506 RPB10 interaction site [polypeptide binding]; other site 886882013507 RPB1 interaction site [polypeptide binding]; other site 886882013508 RPB11 interaction site [polypeptide binding]; other site 886882013509 RPB3 interaction site [polypeptide binding]; other site 886882013510 RPB12 interaction site [polypeptide binding]; other site 886882013511 Methyltransferase domain; Region: Methyltransf_31; pfam13847 886882013512 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882013513 S-adenosylmethionine binding site [chemical binding]; other site 886882013514 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 886882013515 core dimer interface [polypeptide binding]; other site 886882013516 peripheral dimer interface [polypeptide binding]; other site 886882013517 L10 interface [polypeptide binding]; other site 886882013518 L11 interface [polypeptide binding]; other site 886882013519 putative EF-Tu interaction site [polypeptide binding]; other site 886882013520 putative EF-G interaction site [polypeptide binding]; other site 886882013521 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 886882013522 23S rRNA interface [nucleotide binding]; other site 886882013523 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 886882013524 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 886882013525 mRNA/rRNA interface [nucleotide binding]; other site 886882013526 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 886882013527 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 886882013528 23S rRNA interface [nucleotide binding]; other site 886882013529 L7/L12 interface [polypeptide binding]; other site 886882013530 putative thiostrepton binding site; other site 886882013531 L25 interface [polypeptide binding]; other site 886882013532 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 886882013533 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 886882013534 putative homodimer interface [polypeptide binding]; other site 886882013535 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 886882013536 heterodimer interface [polypeptide binding]; other site 886882013537 homodimer interface [polypeptide binding]; other site 886882013538 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 886882013539 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 886882013540 RNA polymerase factor sigma-70; Validated; Region: PRK08295 886882013541 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882013542 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 886882013543 YacP-like NYN domain; Region: NYN_YacP; pfam05991 886882013544 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 886882013545 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 886882013546 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 886882013547 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 886882013548 active site 886882013549 metal binding site [ion binding]; metal-binding site 886882013550 dimerization interface [polypeptide binding]; other site 886882013551 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 886882013552 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 886882013553 active site 886882013554 HIGH motif; other site 886882013555 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 886882013556 KMSKS motif; other site 886882013557 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 886882013558 tRNA binding surface [nucleotide binding]; other site 886882013559 anticodon binding site; other site 886882013560 serine O-acetyltransferase; Region: cysE; TIGR01172 886882013561 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 886882013562 trimer interface [polypeptide binding]; other site 886882013563 active site 886882013564 substrate binding site [chemical binding]; other site 886882013565 CoA binding site [chemical binding]; other site 886882013566 Protein of unknown function (DUF904); Region: DUF904; pfam06005 886882013567 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 886882013568 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 886882013569 HIGH motif; other site 886882013570 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 886882013571 active site 886882013572 KMSKS motif; other site 886882013573 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 886882013574 homotrimer interaction site [polypeptide binding]; other site 886882013575 zinc binding site [ion binding]; other site 886882013576 CDP-binding sites; other site 886882013577 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 886882013578 substrate binding site; other site 886882013579 dimer interface; other site 886882013580 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 886882013581 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 886882013582 putative active site [active] 886882013583 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 886882013584 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 886882013585 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 886882013586 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 886882013587 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 886882013588 DNA repair protein RadA; Provisional; Region: PRK11823 886882013589 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 886882013590 Walker A motif/ATP binding site; other site 886882013591 ATP binding site [chemical binding]; other site 886882013592 Walker B motif; other site 886882013593 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 886882013594 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 886882013595 Clp amino terminal domain; Region: Clp_N; pfam02861 886882013596 Clp amino terminal domain; Region: Clp_N; pfam02861 886882013597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882013598 Walker A motif; other site 886882013599 ATP binding site [chemical binding]; other site 886882013600 Walker B motif; other site 886882013601 arginine finger; other site 886882013602 UvrB/uvrC motif; Region: UVR; pfam02151 886882013603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882013604 Walker A motif; other site 886882013605 ATP binding site [chemical binding]; other site 886882013606 Walker B motif; other site 886882013607 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 886882013608 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 886882013609 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 886882013610 ADP binding site [chemical binding]; other site 886882013611 phosphagen binding site; other site 886882013612 substrate specificity loop; other site 886882013613 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 886882013614 UvrB/uvrC motif; Region: UVR; pfam02151 886882013615 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 886882013616 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 886882013617 Predicted acetyltransferase involved in intracellular survival and related acetyltransferases [General function prediction only]; Region: Eis; COG4552 886882013618 Coenzyme A binding pocket [chemical binding]; other site 886882013619 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 886882013620 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 886882013621 nucleotide binding pocket [chemical binding]; other site 886882013622 K-X-D-G motif; other site 886882013623 catalytic site [active] 886882013624 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 886882013625 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 886882013626 Dimer interface [polypeptide binding]; other site 886882013627 BRCT sequence motif; other site 886882013628 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 886882013629 Part of AAA domain; Region: AAA_19; pfam13245 886882013630 Family description; Region: UvrD_C_2; pfam13538 886882013631 PcrB family; Region: PcrB; pfam01884 886882013632 PcrB_like proteins. One member of this family, a protein from Archaeoglobus fulgidus, has been characterized as a (S)-3-O-geranylgeranylglyceryl phosphate synthase (AfGGGPS). AfGGGPS catalyzes the formation of an ether linkage between...; Region: PcrB_like; cd02812 886882013633 substrate binding site [chemical binding]; other site 886882013634 putative active site [active] 886882013635 dimer interface [polypeptide binding]; other site 886882013636 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 886882013637 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar1; cd08583 886882013638 putative active site [active] 886882013639 catalytic site [active] 886882013640 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 886882013641 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 886882013642 Bacterial sugar transferase; Region: Bac_transf; pfam02397 886882013643 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 886882013644 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 886882013645 Probable Catalytic site; other site 886882013646 metal-binding site 886882013647 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 886882013648 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 886882013649 Probable Catalytic site; other site 886882013650 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 886882013651 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 886882013652 NADP binding site [chemical binding]; other site 886882013653 active site 886882013654 putative substrate binding site [chemical binding]; other site 886882013655 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 886882013656 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 886882013657 NAD binding site [chemical binding]; other site 886882013658 substrate binding site [chemical binding]; other site 886882013659 homodimer interface [polypeptide binding]; other site 886882013660 active site 886882013661 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 886882013662 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 886882013663 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 886882013664 substrate binding site; other site 886882013665 tetramer interface; other site 886882013666 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 886882013667 Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184 886882013668 Probable Catalytic site; other site 886882013669 metal-binding site 886882013670 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 886882013671 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 886882013672 Probable Catalytic site; other site 886882013673 metal-binding site 886882013674 Methyltransferase domain; Region: Methyltransf_11; pfam08241 886882013675 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 886882013676 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 886882013677 Walker A/P-loop; other site 886882013678 ATP binding site [chemical binding]; other site 886882013679 Q-loop/lid; other site 886882013680 ABC transporter signature motif; other site 886882013681 Walker B; other site 886882013682 D-loop; other site 886882013683 H-loop/switch region; other site 886882013684 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 886882013685 putative carbohydrate binding site [chemical binding]; other site 886882013686 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 886882013687 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 886882013688 O-Antigen ligase; Region: Wzy_C; pfam04932 886882013689 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 886882013690 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 886882013691 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 886882013692 active site 886882013693 tetramer interface; other site 886882013694 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 886882013695 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 886882013696 Peptidase family U32; Region: Peptidase_U32; pfam01136 886882013697 Collagenase; Region: DUF3656; pfam12392 886882013698 Peptidase family U32; Region: Peptidase_U32; cl03113 886882013699 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882013700 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 886882013701 Coenzyme A binding pocket [chemical binding]; other site 886882013702 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882013703 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882013704 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 886882013705 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 886882013706 PDZ domain; Region: PDZ_2; pfam13180 886882013707 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09566 886882013708 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 886882013709 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 886882013710 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 886882013711 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 886882013712 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 886882013713 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 886882013714 excinuclease ABC subunit B; Provisional; Region: PRK05298 886882013715 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 886882013716 ATP binding site [chemical binding]; other site 886882013717 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882013718 nucleotide binding region [chemical binding]; other site 886882013719 ATP-binding site [chemical binding]; other site 886882013720 Ultra-violet resistance protein B; Region: UvrB; pfam12344 886882013721 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 886882013722 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 886882013723 flagellar motor protein MotS; Reviewed; Region: PRK06925 886882013724 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 886882013725 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 886882013726 ligand binding site [chemical binding]; other site 886882013727 Spo0E like sporulation regulatory protein; Region: SpoOE-like; pfam09388 886882013728 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882013729 sequence-specific DNA binding site [nucleotide binding]; other site 886882013730 salt bridge; other site 886882013731 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 886882013732 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 886882013733 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 886882013734 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882013735 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882013736 DNA binding residues [nucleotide binding] 886882013737 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 886882013738 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 886882013739 Glycoside hydrolase family 44; Region: Glyco_hydro_44; pfam12891 886882013740 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 886882013741 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882013742 Interdomain contacts; other site 886882013743 Cytokine receptor motif; other site 886882013744 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 886882013745 putative metal binding site [ion binding]; other site 886882013746 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 886882013747 Cellulose binding domain; Region: CBM_3; pfam00942 886882013748 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882013749 S-adenosylmethionine binding site [chemical binding]; other site 886882013750 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 886882013751 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 886882013752 C-terminal peptidase (prc); Region: prc; TIGR00225 886882013753 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 886882013754 protein binding site [polypeptide binding]; other site 886882013755 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 886882013756 Catalytic dyad [active] 886882013757 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 886882013758 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 886882013759 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 886882013760 Peptidase family M23; Region: Peptidase_M23; pfam01551 886882013761 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 886882013762 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 886882013763 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 886882013764 ATP-binding cassette domain of the cell division transporter; Region: ABC_FtsE_transporter; cd03292 886882013765 Walker A/P-loop; other site 886882013766 ATP binding site [chemical binding]; other site 886882013767 Q-loop/lid; other site 886882013768 ABC transporter signature motif; other site 886882013769 Walker B; other site 886882013770 D-loop; other site 886882013771 H-loop/switch region; other site 886882013772 Uncharacterized vancomycin resistance protein [Defense mechanisms]; Region: COG2720 886882013773 VanW like protein; Region: VanW; pfam04294 886882013774 G5 domain; Region: G5; pfam07501 886882013775 S-layer homology domain; Region: SLH; pfam00395 886882013776 S-layer homology domain; Region: SLH; pfam00395 886882013777 S-formylglutathione hydrolase; Region: PLN02442 886882013778 Putative esterase; Region: Esterase; pfam00756 886882013779 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 886882013780 Predicted membrane protein [Function unknown]; Region: COG2246 886882013781 GtrA-like protein; Region: GtrA; pfam04138 886882013782 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 886882013783 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 886882013784 Ligand binding site; other site 886882013785 Putative Catalytic site; other site 886882013786 DXD motif; other site 886882013787 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 886882013788 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 886882013789 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 886882013790 DXD motif; other site 886882013791 argininosuccinate lyase; Provisional; Region: PRK00855 886882013792 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 886882013793 active sites [active] 886882013794 tetramer interface [polypeptide binding]; other site 886882013795 argininosuccinate synthase; Provisional; Region: PRK13820 886882013796 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 886882013797 ANP binding site [chemical binding]; other site 886882013798 Substrate Binding Site II [chemical binding]; other site 886882013799 Substrate Binding Site I [chemical binding]; other site 886882013800 ornithine carbamoyltransferase; Provisional; Region: PRK00779 886882013801 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 886882013802 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 886882013803 acetylornithine aminotransferase; Provisional; Region: PRK02627 886882013804 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 886882013805 inhibitor-cofactor binding pocket; inhibition site 886882013806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 886882013807 catalytic residue [active] 886882013808 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 886882013809 nucleotide binding site [chemical binding]; other site 886882013810 N-acetyl-L-glutamate binding site [chemical binding]; other site 886882013811 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 886882013812 heterotetramer interface [polypeptide binding]; other site 886882013813 active site pocket [active] 886882013814 cleavage site 886882013815 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 886882013816 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 886882013817 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 886882013818 Uncharacterized conserved protein [Function unknown]; Region: COG1284 886882013819 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 886882013820 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 886882013821 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 886882013822 peptide chain release factor 2; Validated; Region: prfB; PRK00578 886882013823 This domain is found in peptide chain release factors; Region: PCRF; smart00937 886882013824 RF-1 domain; Region: RF-1; pfam00472 886882013825 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 886882013826 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 886882013827 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882013828 nucleotide binding region [chemical binding]; other site 886882013829 ATP-binding site [chemical binding]; other site 886882013830 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 886882013831 30S subunit binding site; other site 886882013832 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013833 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013834 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013835 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013836 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013837 Domain of unknown function DUF11; Region: DUF11; cl17728 886882013838 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013839 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013840 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013841 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013842 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013843 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013844 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013845 Domain of unknown function DUF11; Region: DUF11; cl17728 886882013846 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013847 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013848 Domain of unknown function DUF11; Region: DUF11; cl17728 886882013849 conserved repeat domain; Region: B_ant_repeat; TIGR01451 886882013850 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 886882013851 DNA-binding site [nucleotide binding]; DNA binding site 886882013852 RNA-binding motif; other site 886882013853 Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516 886882013854 flagellar capping protein; Validated; Region: fliD; PRK07737 886882013855 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 886882013856 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 886882013857 FlaG protein; Region: FlaG; pfam03646 886882013858 Methyltransferase domain; Region: Methyltransf_23; pfam13489 886882013859 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882013860 S-adenosylmethionine binding site [chemical binding]; other site 886882013861 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 886882013862 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 886882013863 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882013864 NAD(P) binding site [chemical binding]; other site 886882013865 active site 886882013866 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 886882013867 Cephalosporin hydroxylase; Region: CmcI; pfam04989 886882013868 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 886882013869 CDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: CDP_GD_SDR_e; cd05252 886882013870 NAD binding site [chemical binding]; other site 886882013871 homotetramer interface [polypeptide binding]; other site 886882013872 homodimer interface [polypeptide binding]; other site 886882013873 substrate binding site [chemical binding]; other site 886882013874 active site 886882013875 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 886882013876 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 886882013877 substrate binding site; other site 886882013878 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 886882013879 binding surface 886882013880 TPR motif; other site 886882013881 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 886882013882 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 886882013883 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 886882013884 active site 886882013885 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 886882013886 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 886882013887 putative metal binding site; other site 886882013888 TPR repeat; Region: TPR_11; pfam13414 886882013889 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 886882013890 binding surface 886882013891 TPR motif; other site 886882013892 Tetratricopeptide repeat; Region: TPR_16; pfam13432 886882013893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 886882013894 binding surface 886882013895 TPR motif; other site 886882013896 flagellin; Provisional; Region: PRK12804 886882013897 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 886882013898 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 886882013899 carbon storage regulator; Provisional; Region: PRK01712 886882013900 flagellar assembly protein FliW; Provisional; Region: PRK13285 886882013901 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 886882013902 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 886882013903 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 886882013904 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739 886882013905 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 886882013906 FlgN protein; Region: FlgN; pfam05130 886882013907 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 886882013908 flagellar operon protein TIGR03826; Region: YvyF 886882013909 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 886882013910 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 886882013911 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 886882013912 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 886882013913 active site 886882013914 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 886882013915 ATP binding site [chemical binding]; other site 886882013916 putative Mg++ binding site [ion binding]; other site 886882013917 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882013918 nucleotide binding region [chemical binding]; other site 886882013919 ATP-binding site [chemical binding]; other site 886882013920 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 886882013921 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882013922 active site 886882013923 phosphorylation site [posttranslational modification] 886882013924 intermolecular recognition site; other site 886882013925 dimerization interface [polypeptide binding]; other site 886882013926 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 886882013927 DNA binding residues [nucleotide binding] 886882013928 dimerization interface [polypeptide binding]; other site 886882013929 Sensor protein DegS; Region: DegS; pfam05384 886882013930 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 886882013931 Histidine kinase; Region: HisKA_3; pfam07730 886882013932 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882013933 ATP binding site [chemical binding]; other site 886882013934 Mg2+ binding site [ion binding]; other site 886882013935 G-X-G motif; other site 886882013936 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 886882013937 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 886882013938 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882013939 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 886882013940 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 886882013941 HlyD family secretion protein; Region: HlyD_3; pfam13437 886882013942 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 886882013943 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882013944 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882013945 S-adenosylmethionine synthetase; Validated; Region: PRK05250 886882013946 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 886882013947 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 886882013948 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 886882013949 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 886882013950 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882013951 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 886882013952 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882013953 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 886882013954 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 886882013955 HlyD family secretion protein; Region: HlyD_3; pfam13437 886882013956 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 886882013957 Anaerobic c4-dicarboxylate membrane transporter; Region: DcuA_DcuB; cl01040 886882013958 S-layer homology domain; Region: SLH; pfam00395 886882013959 S-layer homology domain; Region: SLH; pfam00395 886882013960 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 886882013961 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 886882013962 Mg++ binding site [ion binding]; other site 886882013963 putative catalytic motif [active] 886882013964 substrate binding site [chemical binding]; other site 886882013965 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 886882013966 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 886882013967 polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609 886882013968 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 886882013969 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 886882013970 active site 886882013971 substrate binding site [chemical binding]; other site 886882013972 metal binding site [ion binding]; metal-binding site 886882013973 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 886882013974 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 886882013975 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 886882013976 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 886882013977 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 886882013978 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 886882013979 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 886882013980 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 886882013981 MreB and similar proteins; Region: MreB_like; cd10225 886882013982 putative protofilament interaction site [polypeptide binding]; other site 886882013983 nucleotide binding site [chemical binding]; other site 886882013984 RodZ interaction site [polypeptide binding]; other site 886882013985 Mg binding site [ion binding]; other site 886882013986 Stage III sporulation protein D; Region: SpoIIID; pfam12116 886882013987 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 886882013988 Peptidase family M23; Region: Peptidase_M23; pfam01551 886882013989 Stage II sporulation protein; Region: SpoIID; pfam08486 886882013990 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 886882013991 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 886882013992 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 886882013993 hinge; other site 886882013994 active site 886882013995 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 886882013996 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 886882013997 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 886882013998 gamma subunit interface [polypeptide binding]; other site 886882013999 epsilon subunit interface [polypeptide binding]; other site 886882014000 LBP interface [polypeptide binding]; other site 886882014001 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 886882014002 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 886882014003 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 886882014004 alpha subunit interaction interface [polypeptide binding]; other site 886882014005 Walker A motif; other site 886882014006 ATP binding site [chemical binding]; other site 886882014007 Walker B motif; other site 886882014008 inhibitor binding site; inhibition site 886882014009 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 886882014010 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 886882014011 core domain interface [polypeptide binding]; other site 886882014012 delta subunit interface [polypeptide binding]; other site 886882014013 epsilon subunit interface [polypeptide binding]; other site 886882014014 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 886882014015 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 886882014016 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 886882014017 beta subunit interaction interface [polypeptide binding]; other site 886882014018 Walker A motif; other site 886882014019 ATP binding site [chemical binding]; other site 886882014020 Walker B motif; other site 886882014021 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 886882014022 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 886882014023 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 886882014024 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 886882014025 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 886882014026 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 886882014027 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 886882014028 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 886882014029 Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527 886882014030 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 886882014031 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 886882014032 active site 886882014033 homodimer interface [polypeptide binding]; other site 886882014034 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 886882014035 active site 886882014036 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882014037 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882014038 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882014039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014040 dimer interface [polypeptide binding]; other site 886882014041 conserved gate region; other site 886882014042 putative PBP binding loops; other site 886882014043 ABC-ATPase subunit interface; other site 886882014044 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 886882014045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014046 dimer interface [polypeptide binding]; other site 886882014047 conserved gate region; other site 886882014048 putative PBP binding loops; other site 886882014049 ABC-ATPase subunit interface; other site 886882014050 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 886882014051 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 886882014052 dimer interface [polypeptide binding]; other site 886882014053 active site 886882014054 glycine-pyridoxal phosphate binding site [chemical binding]; other site 886882014055 folate binding site [chemical binding]; other site 886882014056 hypothetical protein; Provisional; Region: PRK13690 886882014057 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 886882014058 Low molecular weight phosphatase family; Region: LMWPc; cd00115 886882014059 active site 886882014060 Predicted membrane protein [Function unknown]; Region: COG1971 886882014061 Domain of unknown function DUF; Region: DUF204; pfam02659 886882014062 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 886882014063 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 886882014064 Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551 886882014065 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 886882014066 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 886882014067 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 886882014068 peptide chain release factor 1; Validated; Region: prfA; PRK00591 886882014069 This domain is found in peptide chain release factors; Region: PCRF; smart00937 886882014070 RF-1 domain; Region: RF-1; pfam00472 886882014071 GTP-binding protein YchF; Reviewed; Region: PRK09601 886882014072 YchF GTPase; Region: YchF; cd01900 886882014073 G1 box; other site 886882014074 GTP/Mg2+ binding site [chemical binding]; other site 886882014075 Switch I region; other site 886882014076 G2 box; other site 886882014077 Switch II region; other site 886882014078 G3 box; other site 886882014079 G4 box; other site 886882014080 G5 box; other site 886882014081 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 886882014082 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882014083 Coenzyme A binding pocket [chemical binding]; other site 886882014084 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 886882014085 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 886882014086 homotetramer interface [polypeptide binding]; other site 886882014087 FMN binding site [chemical binding]; other site 886882014088 homodimer contacts [polypeptide binding]; other site 886882014089 putative active site [active] 886882014090 putative substrate binding site [chemical binding]; other site 886882014091 Protein of unknown function, DUF606; Region: DUF606; pfam04657 886882014092 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 886882014093 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 886882014094 ligand binding site [chemical binding]; other site 886882014095 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 886882014096 Protein of unknown function, DUF606; Region: DUF606; pfam04657 886882014097 Putative catalytic domain, repeat 1, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_1; cd09129 886882014098 putative active site [active] 886882014099 putative catalytic site [active] 886882014100 Putative catalytic domain, repeat 2, of uncharacterized phospholipase D-like proteins; Region: PLDc_unchar2_2; cd09130 886882014101 PLD-like domain; Region: PLDc_2; pfam13091 886882014102 putative active site [active] 886882014103 putative catalytic site [active] 886882014104 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 886882014105 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 886882014106 putative active site [active] 886882014107 catalytic site [active] 886882014108 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 886882014109 putative active site [active] 886882014110 catalytic site [active] 886882014111 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882014112 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882014113 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 886882014114 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 886882014115 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 886882014116 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 886882014117 putative substrate binding site [chemical binding]; other site 886882014118 putative ATP binding site [chemical binding]; other site 886882014119 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 886882014120 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882014121 putative DNA binding site [nucleotide binding]; other site 886882014122 putative Zn2+ binding site [ion binding]; other site 886882014123 AsnC family; Region: AsnC_trans_reg; pfam01037 886882014124 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 886882014125 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 886882014126 active site 886882014127 metal binding site [ion binding]; metal-binding site 886882014128 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 886882014129 Lysine efflux permease [General function prediction only]; Region: COG1279 886882014130 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 886882014131 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 886882014132 GTP binding site; other site 886882014133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882014134 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 886882014135 putative substrate translocation pore; other site 886882014136 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 886882014137 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 886882014138 active site 886882014139 HIGH motif; other site 886882014140 nucleotide binding site [chemical binding]; other site 886882014141 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 886882014142 KMSKS motif; other site 886882014143 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 886882014144 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 886882014145 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 886882014146 putative acetyltransferase; Provisional; Region: PRK03624 886882014147 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882014148 Coenzyme A binding pocket [chemical binding]; other site 886882014149 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882014150 Major Facilitator Superfamily; Region: MFS_1; pfam07690 886882014151 putative substrate translocation pore; other site 886882014152 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 886882014153 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 886882014154 putative [4Fe-4S] binding site [ion binding]; other site 886882014155 putative molybdopterin cofactor binding site [chemical binding]; other site 886882014156 The MopB_CT_3 CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is of the...; Region: MopB_CT_3; cd02786 886882014157 putative molybdopterin cofactor binding site; other site 886882014158 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 886882014159 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 886882014160 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882014161 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 886882014162 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 886882014163 catalytic residues [active] 886882014164 dimer interface [polypeptide binding]; other site 886882014165 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 886882014166 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 886882014167 Walker A/P-loop; other site 886882014168 ATP binding site [chemical binding]; other site 886882014169 Q-loop/lid; other site 886882014170 ABC transporter signature motif; other site 886882014171 Walker B; other site 886882014172 D-loop; other site 886882014173 H-loop/switch region; other site 886882014174 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 886882014175 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 886882014176 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 886882014177 Domain of unknown function DUF20; Region: UPF0118; pfam01594 886882014178 Transcriptional regulator [Transcription]; Region: LytR; COG1316 886882014179 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 886882014180 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 886882014181 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 886882014182 DEAD-like helicases superfamily; Region: DEXDc; smart00487 886882014183 ATP binding site [chemical binding]; other site 886882014184 Mg++ binding site [ion binding]; other site 886882014185 motif III; other site 886882014186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882014187 nucleotide binding region [chemical binding]; other site 886882014188 ATP-binding site [chemical binding]; other site 886882014189 HEAT repeats; Region: HEAT_2; pfam13646 886882014190 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 886882014191 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 886882014192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882014193 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882014194 WHG domain; Region: WHG; pfam13305 886882014195 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 886882014196 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 886882014197 hydroxyglutarate oxidase; Provisional; Region: PRK11728 886882014198 Predicted peptidase [General function prediction only]; Region: COG4099 886882014199 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 886882014200 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 886882014201 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 886882014202 substrate binding pocket [chemical binding]; other site 886882014203 membrane-bound complex binding site; other site 886882014204 hinge residues; other site 886882014205 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 886882014206 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 886882014207 Walker A/P-loop; other site 886882014208 ATP binding site [chemical binding]; other site 886882014209 Q-loop/lid; other site 886882014210 ABC transporter signature motif; other site 886882014211 Walker B; other site 886882014212 D-loop; other site 886882014213 H-loop/switch region; other site 886882014214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014215 dimer interface [polypeptide binding]; other site 886882014216 conserved gate region; other site 886882014217 ABC-ATPase subunit interface; other site 886882014218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014219 dimer interface [polypeptide binding]; other site 886882014220 conserved gate region; other site 886882014221 putative PBP binding loops; other site 886882014222 ABC-ATPase subunit interface; other site 886882014223 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 886882014224 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 886882014225 Sulfate transporter family; Region: Sulfate_transp; pfam00916 886882014226 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 886882014227 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 886882014228 ABC1 family; Region: ABC1; pfam03109 886882014229 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 886882014230 active site 886882014231 ATP binding site [chemical binding]; other site 886882014232 Uncharacterized conserved protein [Function unknown]; Region: COG3937 886882014233 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 886882014234 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 886882014235 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014 886882014236 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 886882014237 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 886882014238 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 886882014239 catalytic triad [active] 886882014240 cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788 886882014241 Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760 886882014242 Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761 886882014243 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 886882014244 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 886882014245 Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798 886882014246 active site 886882014247 SAM binding site [chemical binding]; other site 886882014248 homodimer interface [polypeptide binding]; other site 886882014249 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 886882014250 active site 886882014251 SAM binding site [chemical binding]; other site 886882014252 homodimer interface [polypeptide binding]; other site 886882014253 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 886882014254 active site 886882014255 putative homodimer interface [polypeptide binding]; other site 886882014256 SAM binding site [chemical binding]; other site 886882014257 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 886882014258 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882014259 S-adenosylmethionine binding site [chemical binding]; other site 886882014260 cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075 886882014261 Precorrin-8X methylmutase; Region: CbiC; pfam02570 886882014262 cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913 886882014263 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 886882014264 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 886882014265 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 886882014266 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 886882014267 putative active site [active] 886882014268 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), C-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_C; cd03414 886882014269 putative active site [active] 886882014270 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 886882014271 active site 886882014272 SAM binding site [chemical binding]; other site 886882014273 homodimer interface [polypeptide binding]; other site 886882014274 Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077 886882014275 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 886882014276 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 886882014277 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 886882014278 active site 886882014279 Spore germination protein; Region: Spore_permease; cl17796 886882014280 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 886882014281 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 886882014282 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 886882014283 Pirin-related protein [General function prediction only]; Region: COG1741 886882014284 Pirin; Region: Pirin; pfam02678 886882014285 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 886882014286 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882014287 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882014288 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 886882014289 putative dimerization interface [polypeptide binding]; other site 886882014290 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 886882014291 EamA-like transporter family; Region: EamA; pfam00892 886882014292 Cache domain; Region: Cache_1; pfam02743 886882014293 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882014294 dimerization interface [polypeptide binding]; other site 886882014295 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 886882014296 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882014297 dimer interface [polypeptide binding]; other site 886882014298 putative CheW interface [polypeptide binding]; other site 886882014299 Predicted membrane protein [Function unknown]; Region: COG2259 886882014300 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 886882014301 Penicillinase repressor; Region: Pencillinase_R; pfam03965 886882014302 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882014303 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882014304 DNA binding site [nucleotide binding] 886882014305 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 886882014306 metal binding site 2 [ion binding]; metal-binding site 886882014307 putative DNA binding helix; other site 886882014308 metal binding site 1 [ion binding]; metal-binding site 886882014309 dimer interface [polypeptide binding]; other site 886882014310 structural Zn2+ binding site [ion binding]; other site 886882014311 Spore germination protein; Region: Spore_permease; cl17796 886882014312 germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887 886882014313 Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504 886882014314 Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323 886882014315 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 886882014316 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 886882014317 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 886882014318 metal binding site [ion binding]; metal-binding site 886882014319 active site 886882014320 I-site; other site 886882014321 Transcriptional regulator; Region: Rrf2; pfam02082 886882014322 Rrf2 family protein; Region: rrf2_super; TIGR00738 886882014323 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 886882014324 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 886882014325 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 886882014326 Carbohydrate Binding Module 6 (CBM6); many are appended to glycoside hydrolase (GH) family 11 and GH43 xylanase domains; Region: CBM6_xylanase-like; cd04084 886882014327 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 886882014328 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 886882014329 Class III ribonucleotide reductase; Region: RNR_III; cd01675 886882014330 effector binding site; other site 886882014331 active site 886882014332 Zn binding site [ion binding]; other site 886882014333 glycine loop; other site 886882014334 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 886882014335 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 886882014336 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 886882014337 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 886882014338 THF binding site; other site 886882014339 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 886882014340 substrate binding site [chemical binding]; other site 886882014341 THF binding site; other site 886882014342 zinc-binding site [ion binding]; other site 886882014343 Predicted transcriptional regulators [Transcription]; Region: COG1695 886882014344 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 886882014345 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 886882014346 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 886882014347 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 886882014348 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 886882014349 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 886882014350 classical (c) SDRs; Region: SDR_c; cd05233 886882014351 NAD(P) binding site [chemical binding]; other site 886882014352 active site 886882014353 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 886882014354 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 886882014355 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 886882014356 Nitric oxide synthase (NOS) produces nitric oxide (NO) by catalyzing a five-electron heme-based oxidation of a guanidine nitrogen of L-arginine to L-citrulline via two successive monooxygenation reactions producing N(omega)-hydroxy-L-arginine (NHA) as an...; Region: NOS_oxygenase; cd00575 886882014357 active site 886882014358 dimer interface [polypeptide binding]; other site 886882014359 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 886882014360 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 886882014361 dimerization interface [polypeptide binding]; other site 886882014362 DPS ferroxidase diiron center [ion binding]; other site 886882014363 ion pore; other site 886882014364 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 886882014365 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 886882014366 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 886882014367 active site 886882014368 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 886882014369 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 886882014370 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882014371 Walker A/P-loop; other site 886882014372 ATP binding site [chemical binding]; other site 886882014373 Q-loop/lid; other site 886882014374 ABC transporter signature motif; other site 886882014375 Walker B; other site 886882014376 D-loop; other site 886882014377 H-loop/switch region; other site 886882014378 TOBE domain; Region: TOBE_2; pfam08402 886882014379 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 886882014380 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014381 dimer interface [polypeptide binding]; other site 886882014382 conserved gate region; other site 886882014383 putative PBP binding loops; other site 886882014384 ABC-ATPase subunit interface; other site 886882014385 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 886882014386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014387 dimer interface [polypeptide binding]; other site 886882014388 conserved gate region; other site 886882014389 putative PBP binding loops; other site 886882014390 ABC-ATPase subunit interface; other site 886882014391 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 886882014392 active site 886882014393 tetramer interface [polypeptide binding]; other site 886882014394 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 886882014395 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 886882014396 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 886882014397 nucleophilic elbow; other site 886882014398 catalytic triad; other site 886882014399 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 886882014400 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 886882014401 Domain of unknown function (DUF4163); Region: DUF4163; pfam13739 886882014402 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 886882014403 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 886882014404 Domain of unknown function (DUF4280); Region: DUF4280; pfam14107 886882014405 GAF domain; Region: GAF_3; pfam13492 886882014406 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882014407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882014408 ATP binding site [chemical binding]; other site 886882014409 Mg2+ binding site [ion binding]; other site 886882014410 G-X-G motif; other site 886882014411 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 886882014412 active site 886882014413 dimerization interface [polypeptide binding]; other site 886882014414 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 886882014415 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 886882014416 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 886882014417 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 886882014418 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 886882014419 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882014420 putative DNA binding site [nucleotide binding]; other site 886882014421 putative Zn2+ binding site [ion binding]; other site 886882014422 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 886882014423 DEAD_2; Region: DEAD_2; pfam06733 886882014424 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 886882014425 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 886882014426 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 886882014427 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 886882014428 metal binding site [ion binding]; metal-binding site 886882014429 active site 886882014430 I-site; other site 886882014431 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882014432 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882014433 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 886882014434 putative dimerization interface [polypeptide binding]; other site 886882014435 holin-like protein; Validated; Region: PRK01658 886882014436 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 886882014437 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 886882014438 glycerol kinase; Provisional; Region: glpK; PRK00047 886882014439 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 886882014440 N- and C-terminal domain interface [polypeptide binding]; other site 886882014441 active site 886882014442 MgATP binding site [chemical binding]; other site 886882014443 catalytic site [active] 886882014444 metal binding site [ion binding]; metal-binding site 886882014445 glycerol binding site [chemical binding]; other site 886882014446 homotetramer interface [polypeptide binding]; other site 886882014447 homodimer interface [polypeptide binding]; other site 886882014448 FBP binding site [chemical binding]; other site 886882014449 protein IIAGlc interface [polypeptide binding]; other site 886882014450 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 886882014451 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 886882014452 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 886882014453 substrate binding pocket [chemical binding]; other site 886882014454 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 886882014455 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 886882014456 NADH(P)-binding; Region: NAD_binding_10; pfam13460 886882014457 NAD binding site [chemical binding]; other site 886882014458 substrate binding site [chemical binding]; other site 886882014459 putative active site [active] 886882014460 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 886882014461 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 886882014462 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 886882014463 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 886882014464 H+ Antiporter protein; Region: 2A0121; TIGR00900 886882014465 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882014466 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882014467 DNA binding site [nucleotide binding] 886882014468 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 886882014469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882014470 putative substrate translocation pore; other site 886882014471 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 886882014472 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 886882014473 NADP binding site [chemical binding]; other site 886882014474 homodimer interface [polypeptide binding]; other site 886882014475 active site 886882014476 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 886882014477 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 886882014478 active site 886882014479 intersubunit interface [polypeptide binding]; other site 886882014480 catalytic residue [active] 886882014481 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 886882014482 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 886882014483 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 886882014484 substrate binding site [chemical binding]; other site 886882014485 ATP binding site [chemical binding]; other site 886882014486 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882014487 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882014488 DNA binding site [nucleotide binding] 886882014489 domain linker motif; other site 886882014490 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 886882014491 putative dimerization interface [polypeptide binding]; other site 886882014492 putative ligand binding site [chemical binding]; other site 886882014493 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 886882014494 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 886882014495 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 886882014496 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 886882014497 NAD(P) binding site [chemical binding]; other site 886882014498 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 886882014499 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882014500 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882014501 DNA binding residues [nucleotide binding] 886882014502 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 886882014503 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882014504 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014505 putative PBP binding loops; other site 886882014506 dimer interface [polypeptide binding]; other site 886882014507 ABC-ATPase subunit interface; other site 886882014508 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014509 dimer interface [polypeptide binding]; other site 886882014510 conserved gate region; other site 886882014511 putative PBP binding loops; other site 886882014512 ABC-ATPase subunit interface; other site 886882014513 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882014514 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882014515 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 886882014516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882014517 Walker A/P-loop; other site 886882014518 ATP binding site [chemical binding]; other site 886882014519 Q-loop/lid; other site 886882014520 ABC transporter signature motif; other site 886882014521 Walker B; other site 886882014522 D-loop; other site 886882014523 H-loop/switch region; other site 886882014524 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 886882014525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882014526 Walker A/P-loop; other site 886882014527 ATP binding site [chemical binding]; other site 886882014528 Q-loop/lid; other site 886882014529 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 886882014530 ABC transporter signature motif; other site 886882014531 Walker B; other site 886882014532 D-loop; other site 886882014533 ABC transporter; Region: ABC_tran_2; pfam12848 886882014534 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 886882014535 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 886882014536 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882014537 putative substrate translocation pore; other site 886882014538 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 886882014539 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 886882014540 Domain of unknown function (DUF377); Region: DUF377; pfam04041 886882014541 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 886882014542 active site 886882014543 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882014544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014545 dimer interface [polypeptide binding]; other site 886882014546 conserved gate region; other site 886882014547 putative PBP binding loops; other site 886882014548 ABC-ATPase subunit interface; other site 886882014549 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014550 dimer interface [polypeptide binding]; other site 886882014551 conserved gate region; other site 886882014552 putative PBP binding loops; other site 886882014553 ABC-ATPase subunit interface; other site 886882014554 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882014555 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 886882014556 dimerization interface [polypeptide binding]; other site 886882014557 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 886882014558 putative active cleft [active] 886882014559 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 886882014560 active site 886882014561 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882014562 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 886882014563 DNA binding site [nucleotide binding] 886882014564 domain linker motif; other site 886882014565 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 886882014566 hypothetical protein; Provisional; Region: PRK04164 886882014567 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 886882014568 CsbD-like; Region: CsbD; pfam05532 886882014569 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882014570 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882014571 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 886882014572 substrate binding site [chemical binding]; other site 886882014573 active site 886882014574 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 886882014575 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 886882014576 Uncharacterized conserved protein [Function unknown]; Region: COG2427 886882014577 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 886882014578 active site residue [active] 886882014579 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 886882014580 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 886882014581 active site 886882014582 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 886882014583 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 886882014584 active site 886882014585 Na/Ca binding site [ion binding]; other site 886882014586 catalytic site [active] 886882014587 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 886882014588 catalytic core [active] 886882014589 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 886882014590 Bax inhibitor 1 like; Region: BaxI_1; cl17691 886882014591 peptidase T; Region: peptidase-T; TIGR01882 886882014592 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 886882014593 metal binding site [ion binding]; metal-binding site 886882014594 dimer interface [polypeptide binding]; other site 886882014595 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882014596 dimer interface [polypeptide binding]; other site 886882014597 putative CheW interface [polypeptide binding]; other site 886882014598 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 886882014599 active site 886882014600 dimer interface [polypeptide binding]; other site 886882014601 magnesium binding site [ion binding]; other site 886882014602 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 886882014603 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 886882014604 tetramer interface [polypeptide binding]; other site 886882014605 active site 886882014606 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 886882014607 active site 886882014608 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882014609 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014610 dimer interface [polypeptide binding]; other site 886882014611 conserved gate region; other site 886882014612 ABC-ATPase subunit interface; other site 886882014613 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 886882014614 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014615 dimer interface [polypeptide binding]; other site 886882014616 conserved gate region; other site 886882014617 ABC-ATPase subunit interface; other site 886882014618 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882014619 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 886882014620 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 886882014621 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 886882014622 Walker A/P-loop; other site 886882014623 ATP binding site [chemical binding]; other site 886882014624 Q-loop/lid; other site 886882014625 ABC transporter signature motif; other site 886882014626 Walker B; other site 886882014627 D-loop; other site 886882014628 H-loop/switch region; other site 886882014629 FtsX-like permease family; Region: FtsX; pfam02687 886882014630 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 886882014631 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 886882014632 HAMP domain; Region: HAMP; pfam00672 886882014633 Histidine kinase; Region: His_kinase; pfam06580 886882014634 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882014635 ATP binding site [chemical binding]; other site 886882014636 Mg2+ binding site [ion binding]; other site 886882014637 G-X-G motif; other site 886882014638 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882014639 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 886882014640 active site 886882014641 phosphorylation site [posttranslational modification] 886882014642 intermolecular recognition site; other site 886882014643 dimerization interface [polypeptide binding]; other site 886882014644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882014645 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 886882014646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 886882014647 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 886882014648 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 886882014649 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 886882014650 Rubredoxin [Energy production and conversion]; Region: COG1773 886882014651 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 886882014652 iron binding site [ion binding]; other site 886882014653 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 886882014654 global nitrogen regulator NtcA, cyanobacterial; Region: NtcA_cyano; TIGR03697 886882014655 ligand binding site [chemical binding]; other site 886882014656 flexible hinge region; other site 886882014657 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 886882014658 putative switch regulator; other site 886882014659 non-specific DNA interactions [nucleotide binding]; other site 886882014660 DNA binding site [nucleotide binding] 886882014661 sequence specific DNA binding site [nucleotide binding]; other site 886882014662 putative cAMP binding site [chemical binding]; other site 886882014663 Domain of unknown function (DUF4304); Region: DUF4304; pfam14137 886882014664 Predicted integral membrane protein [Function unknown]; Region: COG5542 886882014665 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 886882014666 Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426 886882014667 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 886882014668 NADH(P)-binding; Region: NAD_binding_10; pfam13460 886882014669 NAD(P) binding site [chemical binding]; other site 886882014670 putative active site [active] 886882014671 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882014672 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882014673 WHG domain; Region: WHG; pfam13305 886882014674 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 886882014675 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 886882014676 Walker A/P-loop; other site 886882014677 ATP binding site [chemical binding]; other site 886882014678 Q-loop/lid; other site 886882014679 ABC transporter signature motif; other site 886882014680 Walker B; other site 886882014681 D-loop; other site 886882014682 H-loop/switch region; other site 886882014683 Uncharacterized protein family (UPF0014); Region: UPF0014; cl00424 886882014684 General stress protein [General function prediction only]; Region: GsiB; COG3729 886882014685 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882014686 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882014687 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 886882014688 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 886882014689 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882014690 Helix-turn-helix domain; Region: HTH_18; pfam12833 886882014691 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882014692 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 886882014693 Alpha-glucuronidase [Carbohydrate transport and metabolism]; Region: AguA; COG3661 886882014694 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 886882014695 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 886882014696 Glycosyl hydrolase family 14; Region: Glyco_hydro_14; pfam01373 886882014697 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 886882014698 Carbohydrate binding domain (family 25); Region: CBM_25; pfam03423 886882014699 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 886882014700 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 886882014701 active site 886882014702 catalytic site [active] 886882014703 Aamy_C domain; Region: Aamy_C; smart00632 886882014704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 886882014705 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 886882014706 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 886882014707 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 886882014708 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 886882014709 Walker A/P-loop; other site 886882014710 ATP binding site [chemical binding]; other site 886882014711 Q-loop/lid; other site 886882014712 ABC transporter signature motif; other site 886882014713 Walker B; other site 886882014714 D-loop; other site 886882014715 H-loop/switch region; other site 886882014716 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 886882014717 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 886882014718 active site 886882014719 FMN binding site [chemical binding]; other site 886882014720 substrate binding site [chemical binding]; other site 886882014721 homotetramer interface [polypeptide binding]; other site 886882014722 catalytic residue [active] 886882014723 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 886882014724 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 886882014725 Response regulator receiver domain; Region: Response_reg; pfam00072 886882014726 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882014727 active site 886882014728 phosphorylation site [posttranslational modification] 886882014729 intermolecular recognition site; other site 886882014730 dimerization interface [polypeptide binding]; other site 886882014731 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882014732 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882014733 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 886882014734 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882014735 dimerization interface [polypeptide binding]; other site 886882014736 Histidine kinase; Region: His_kinase; pfam06580 886882014737 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882014738 ATP binding site [chemical binding]; other site 886882014739 Mg2+ binding site [ion binding]; other site 886882014740 G-X-G motif; other site 886882014741 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 886882014742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014743 dimer interface [polypeptide binding]; other site 886882014744 conserved gate region; other site 886882014745 putative PBP binding loops; other site 886882014746 ABC-ATPase subunit interface; other site 886882014747 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 886882014748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014749 dimer interface [polypeptide binding]; other site 886882014750 conserved gate region; other site 886882014751 putative PBP binding loops; other site 886882014752 ABC-ATPase subunit interface; other site 886882014753 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 886882014754 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 886882014755 Catalytic site [active] 886882014756 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 886882014757 Right handed beta helix region; Region: Beta_helix; pfam13229 886882014758 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 886882014759 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 886882014760 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 886882014761 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 886882014762 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 886882014763 NodB motif; other site 886882014764 active site 886882014765 catalytic site [active] 886882014766 Zn binding site [ion binding]; other site 886882014767 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 886882014768 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 886882014769 catalytic triad [active] 886882014770 catalytic triad [active] 886882014771 oxyanion hole [active] 886882014772 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 886882014773 putative substrate binding site 1 [chemical binding]; other site 886882014774 Na binding site 1 [ion binding]; other site 886882014775 putative substrate binding site 2 [chemical binding]; other site 886882014776 Na2 binding site [ion binding]; other site 886882014777 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 886882014778 seryl-tRNA synthetase; Provisional; Region: PRK05431 886882014779 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 886882014780 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 886882014781 dimer interface [polypeptide binding]; other site 886882014782 active site 886882014783 motif 1; other site 886882014784 motif 2; other site 886882014785 motif 3; other site 886882014786 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 886882014787 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 886882014788 heme-binding site [chemical binding]; other site 886882014789 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 886882014790 FAD binding pocket [chemical binding]; other site 886882014791 FAD binding motif [chemical binding]; other site 886882014792 phosphate binding motif [ion binding]; other site 886882014793 beta-alpha-beta structure motif; other site 886882014794 NAD binding pocket [chemical binding]; other site 886882014795 Heme binding pocket [chemical binding]; other site 886882014796 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 886882014797 active site 886882014798 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 886882014799 sugar binding site [chemical binding]; other site 886882014800 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 886882014801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882014802 DNA-binding site [nucleotide binding]; DNA binding site 886882014803 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 886882014804 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 886882014805 beta-galactosidase; Region: BGL; TIGR03356 886882014806 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 886882014807 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 886882014808 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 886882014809 active site 886882014810 methionine cluster; other site 886882014811 phosphorylation site [posttranslational modification] 886882014812 metal binding site [ion binding]; metal-binding site 886882014813 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 886882014814 active site 886882014815 P-loop; other site 886882014816 phosphorylation site [posttranslational modification] 886882014817 KWG Leptospira; Region: KWG; pfam07656 886882014818 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 886882014819 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 886882014820 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 886882014821 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 886882014822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882014823 non-specific DNA binding site [nucleotide binding]; other site 886882014824 salt bridge; other site 886882014825 sequence-specific DNA binding site [nucleotide binding]; other site 886882014826 Predicted transcriptional regulator [Transcription]; Region: COG2378 886882014827 HTH domain; Region: HTH_11; pfam08279 886882014828 WYL domain; Region: WYL; pfam13280 886882014829 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 886882014830 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 886882014831 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 886882014832 active site 886882014833 homodimer interface [polypeptide binding]; other site 886882014834 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 886882014835 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 886882014836 Walker A/P-loop; other site 886882014837 ATP binding site [chemical binding]; other site 886882014838 Q-loop/lid; other site 886882014839 ABC transporter signature motif; other site 886882014840 Walker B; other site 886882014841 D-loop; other site 886882014842 H-loop/switch region; other site 886882014843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014844 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 886882014845 dimer interface [polypeptide binding]; other site 886882014846 conserved gate region; other site 886882014847 putative PBP binding loops; other site 886882014848 ABC-ATPase subunit interface; other site 886882014849 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 886882014850 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 886882014851 substrate binding pocket [chemical binding]; other site 886882014852 membrane-bound complex binding site; other site 886882014853 hinge residues; other site 886882014854 nickel import ATP-binding protein NikE; Region: nickel_nikE; TIGR02769 886882014855 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 886882014856 Walker A/P-loop; other site 886882014857 ATP binding site [chemical binding]; other site 886882014858 Q-loop/lid; other site 886882014859 ABC transporter signature motif; other site 886882014860 Walker B; other site 886882014861 D-loop; other site 886882014862 H-loop/switch region; other site 886882014863 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 886882014864 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 886882014865 Walker A/P-loop; other site 886882014866 ATP binding site [chemical binding]; other site 886882014867 Q-loop/lid; other site 886882014868 ABC transporter signature motif; other site 886882014869 Walker B; other site 886882014870 D-loop; other site 886882014871 H-loop/switch region; other site 886882014872 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 886882014873 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 886882014874 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 886882014875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014876 dimer interface [polypeptide binding]; other site 886882014877 conserved gate region; other site 886882014878 putative PBP binding loops; other site 886882014879 ABC-ATPase subunit interface; other site 886882014880 nickel ABC transporter, permease subunit NikB; Region: nickel_nikB; TIGR02789 886882014881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014882 dimer interface [polypeptide binding]; other site 886882014883 conserved gate region; other site 886882014884 putative PBP binding loops; other site 886882014885 ABC-ATPase subunit interface; other site 886882014886 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 886882014887 substrate binding site [chemical binding]; other site 886882014888 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 886882014889 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 886882014890 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 886882014891 Walker A/P-loop; other site 886882014892 ATP binding site [chemical binding]; other site 886882014893 Q-loop/lid; other site 886882014894 ABC transporter signature motif; other site 886882014895 Walker B; other site 886882014896 D-loop; other site 886882014897 H-loop/switch region; other site 886882014898 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 886882014899 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 886882014900 Walker A/P-loop; other site 886882014901 ATP binding site [chemical binding]; other site 886882014902 Q-loop/lid; other site 886882014903 ABC transporter signature motif; other site 886882014904 Walker B; other site 886882014905 D-loop; other site 886882014906 H-loop/switch region; other site 886882014907 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 886882014908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014909 dimer interface [polypeptide binding]; other site 886882014910 conserved gate region; other site 886882014911 putative PBP binding loops; other site 886882014912 ABC-ATPase subunit interface; other site 886882014913 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 886882014914 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882014915 dimer interface [polypeptide binding]; other site 886882014916 conserved gate region; other site 886882014917 putative PBP binding loops; other site 886882014918 ABC-ATPase subunit interface; other site 886882014919 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 886882014920 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490 886882014921 xanthine permease; Region: pbuX; TIGR03173 886882014922 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 886882014923 active site 886882014924 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 886882014925 N- and C-terminal domain interface [polypeptide binding]; other site 886882014926 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 886882014927 active site 886882014928 putative catalytic site [active] 886882014929 metal binding site [ion binding]; metal-binding site 886882014930 ATP binding site [chemical binding]; other site 886882014931 carbohydrate binding site [chemical binding]; other site 886882014932 L-rhamnose isomerase; Provisional; Region: PRK01076 886882014933 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 886882014934 intersubunit interface [polypeptide binding]; other site 886882014935 active site 886882014936 Zn2+ binding site [ion binding]; other site 886882014937 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 886882014938 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882014939 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882014940 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882014941 Predicted membrane protein (DUF2157); Region: DUF2157; pfam09925 886882014942 GDYXXLXY protein; Region: GDYXXLXY; pfam14345 886882014943 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 886882014944 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 886882014945 Membrane transport protein; Region: Mem_trans; cl09117 886882014946 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 886882014947 (R)-2-Hydroxyglutarate Dehydrogenase and related dehydrogenases, NAD-binding and catalytic domains; Region: HGDH_like; cd12184 886882014948 putative homodimer interface [polypeptide binding]; other site 886882014949 putative ligand binding site [chemical binding]; other site 886882014950 putative NAD binding site [chemical binding]; other site 886882014951 catalytic site [active] 886882014952 Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565 886882014953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882014954 active site 886882014955 phosphorylation site [posttranslational modification] 886882014956 intermolecular recognition site; other site 886882014957 dimerization interface [polypeptide binding]; other site 886882014958 HTH domain; Region: HTH_11; pfam08279 886882014959 Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290 886882014960 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882014961 ATP binding site [chemical binding]; other site 886882014962 Mg2+ binding site [ion binding]; other site 886882014963 G-X-G motif; other site 886882014964 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 886882014965 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 886882014966 heterodimer interface [polypeptide binding]; other site 886882014967 active site 886882014968 FMN binding site [chemical binding]; other site 886882014969 homodimer interface [polypeptide binding]; other site 886882014970 substrate binding site [chemical binding]; other site 886882014971 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 886882014972 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 886882014973 FAD binding pocket [chemical binding]; other site 886882014974 FAD binding motif [chemical binding]; other site 886882014975 phosphate binding motif [ion binding]; other site 886882014976 beta-alpha-beta structure motif; other site 886882014977 NAD binding pocket [chemical binding]; other site 886882014978 Iron coordination center [ion binding]; other site 886882014979 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 886882014980 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882014981 FeS/SAM binding site; other site 886882014982 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 886882014983 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 886882014984 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 886882014985 Transcriptional regulator [Transcription]; Region: LysR; COG0583 886882014986 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 886882014987 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 886882014988 dimerization interface [polypeptide binding]; other site 886882014989 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 886882014990 classical (c) SDRs; Region: SDR_c; cd05233 886882014991 NAD(P) binding site [chemical binding]; other site 886882014992 active site 886882014993 YheC/D like ATP-grasp; Region: ATPgrasp_YheCD; pfam14398 886882014994 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 886882014995 catalytic residues [active] 886882014996 dimer interface [polypeptide binding]; other site 886882014997 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 886882014998 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882014999 DNA-binding interface [nucleotide binding]; DNA binding site 886882015000 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 886882015001 tetrahydroxynaphthalene/trihydroxynaphthalene reductase-like, classical (c) SDRs; Region: THN_reductase-like_SDR_c; cd05362 886882015002 NADP binding site [chemical binding]; other site 886882015003 homodimer interface [polypeptide binding]; other site 886882015004 active site 886882015005 substrate binding site [chemical binding]; other site 886882015006 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 886882015007 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 886882015008 ligand binding site [chemical binding]; other site 886882015009 flexible hinge region; other site 886882015010 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 886882015011 non-specific DNA interactions [nucleotide binding]; other site 886882015012 DNA binding site [nucleotide binding] 886882015013 sequence specific DNA binding site [nucleotide binding]; other site 886882015014 putative cAMP binding site [chemical binding]; other site 886882015015 DinB superfamily; Region: DinB_2; pfam12867 886882015016 Predicted transcriptional regulator [Transcription]; Region: COG2378 886882015017 HTH domain; Region: HTH_11; pfam08279 886882015018 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 886882015019 WYL domain; Region: WYL; pfam13280 886882015020 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 886882015021 GIY-YIG motif/motif A; other site 886882015022 active site 886882015023 catalytic site [active] 886882015024 putative DNA binding site [nucleotide binding]; other site 886882015025 metal binding site [ion binding]; metal-binding site 886882015026 GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685 886882015027 Predicted transcriptional regulators [Transcription]; Region: COG1733 886882015028 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 886882015029 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 886882015030 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 886882015031 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 886882015032 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 886882015033 YhfW family, C-terminal Rieske domain; YhfW is a protein of unknown function with an N-terminal DadA-like (glycine/D-amino acid dehydrogenase) domain and a C-terminal Rieske domain. The Rieske domain is a [2Fe-2S] cluster binding domain involved in...; Region: Rieske_YhfW_C; cd03477 886882015034 [2Fe-2S] cluster binding site [ion binding]; other site 886882015035 Coat F domain; Region: Coat_F; cl17715 886882015036 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 886882015037 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 886882015038 NAD binding site [chemical binding]; other site 886882015039 catalytic Zn binding site [ion binding]; other site 886882015040 structural Zn binding site [ion binding]; other site 886882015041 Spore coat protein [Cell envelope biogenesis, outer membrane]; Region: COG5577 886882015042 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 886882015043 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 886882015044 active site 886882015045 catalytic tetrad [active] 886882015046 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 886882015047 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 886882015048 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 886882015049 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 886882015050 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 886882015051 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 886882015052 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 886882015053 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 886882015054 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882015055 Zn2+ binding site [ion binding]; other site 886882015056 Mg2+ binding site [ion binding]; other site 886882015057 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882015058 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882015059 active site 886882015060 phosphorylation site [posttranslational modification] 886882015061 intermolecular recognition site; other site 886882015062 dimerization interface [polypeptide binding]; other site 886882015063 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882015064 DNA binding site [nucleotide binding] 886882015065 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 886882015066 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882015067 ATP binding site [chemical binding]; other site 886882015068 Mg2+ binding site [ion binding]; other site 886882015069 G-X-G motif; other site 886882015070 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 886882015071 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 886882015072 Walker A/P-loop; other site 886882015073 ATP binding site [chemical binding]; other site 886882015074 Q-loop/lid; other site 886882015075 ABC transporter signature motif; other site 886882015076 Walker B; other site 886882015077 D-loop; other site 886882015078 H-loop/switch region; other site 886882015079 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 886882015080 FtsX-like permease family; Region: FtsX; pfam02687 886882015081 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 886882015082 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 886882015083 active site 886882015084 catalytic tetrad [active] 886882015085 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 886882015086 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 886882015087 FeS/SAM binding site; other site 886882015088 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 886882015089 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 886882015090 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 886882015091 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 886882015092 catalytic residue [active] 886882015093 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 886882015094 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 886882015095 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 886882015096 Uncharacterized conserved protein [Function unknown]; Region: COG2013 886882015097 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 886882015098 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 886882015099 PhnA protein; Region: PhnA; pfam03831 886882015100 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 886882015101 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 886882015102 NADP binding site [chemical binding]; other site 886882015103 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 886882015104 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 886882015105 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 886882015106 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 886882015107 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 886882015108 Protein of unknown function (DUF3243); Region: DUF3243; pfam11588 886882015109 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 886882015110 active site 886882015111 P-loop; other site 886882015112 phosphorylation site [posttranslational modification] 886882015113 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 886882015114 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 886882015115 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 886882015116 active site 886882015117 phosphorylation site [posttranslational modification] 886882015118 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 886882015119 HTH domain; Region: HTH_11; pfam08279 886882015120 Mga helix-turn-helix domain; Region: Mga; pfam05043 886882015121 PRD domain; Region: PRD; pfam00874 886882015122 PRD domain; Region: PRD; pfam00874 886882015123 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 886882015124 active site 886882015125 P-loop; other site 886882015126 phosphorylation site [posttranslational modification] 886882015127 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 886882015128 active site 886882015129 phosphorylation site [posttranslational modification] 886882015130 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882015131 Coenzyme A binding pocket [chemical binding]; other site 886882015132 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 886882015133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 886882015134 Coenzyme A binding pocket [chemical binding]; other site 886882015135 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 886882015136 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 886882015137 RDD family; Region: RDD; pfam06271 886882015138 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 886882015139 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 886882015140 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 886882015141 glycerate kinase; Region: TIGR00045 886882015142 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 886882015143 fructuronate transporter; Provisional; Region: PRK10034; cl15264 886882015144 Transcriptional regulators [Transcription]; Region: GntR; COG1802 886882015145 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882015146 DNA-binding site [nucleotide binding]; DNA binding site 886882015147 FCD domain; Region: FCD; pfam07729 886882015148 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 886882015149 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 886882015150 N- and C-terminal domain interface [polypeptide binding]; other site 886882015151 active site 886882015152 catalytic site [active] 886882015153 metal binding site [ion binding]; metal-binding site 886882015154 carbohydrate binding site [chemical binding]; other site 886882015155 ATP binding site [chemical binding]; other site 886882015156 fructuronate transporter; Provisional; Region: PRK10034; cl15264 886882015157 gluconate transporter; Region: gntP; TIGR00791 886882015158 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 886882015159 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882015160 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882015161 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 886882015162 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 886882015163 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 886882015164 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 886882015165 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 886882015166 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882015167 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882015168 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 886882015169 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 886882015170 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 886882015171 ATP binding site [chemical binding]; other site 886882015172 Mg++ binding site [ion binding]; other site 886882015173 motif III; other site 886882015174 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882015175 nucleotide binding region [chemical binding]; other site 886882015176 ATP-binding site [chemical binding]; other site 886882015177 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 886882015178 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 886882015179 RNA polymerase sigma factor SigX; Provisional; Region: PRK09639 886882015180 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882015181 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882015182 DNA binding residues [nucleotide binding] 886882015183 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 886882015184 catalytic core [active] 886882015185 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 886882015186 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 886882015187 NADP binding site [chemical binding]; other site 886882015188 active site 886882015189 substrate binding site [chemical binding]; other site 886882015190 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 886882015191 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 886882015192 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 886882015193 malate:quinone oxidoreductase; Validated; Region: PRK05257 886882015194 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 886882015195 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 886882015196 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882015197 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882015198 DNA binding residues [nucleotide binding] 886882015199 hypothetical protein; Provisional; Region: PRK06761 886882015200 L-arabinose isomerase; Provisional; Region: PRK02929 886882015201 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 886882015202 hexamer (dimer of trimers) interface [polypeptide binding]; other site 886882015203 trimer interface [polypeptide binding]; other site 886882015204 substrate binding site [chemical binding]; other site 886882015205 Mn binding site [ion binding]; other site 886882015206 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 886882015207 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 886882015208 intersubunit interface [polypeptide binding]; other site 886882015209 active site 886882015210 Zn2+ binding site [ion binding]; other site 886882015211 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 886882015212 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 886882015213 putative N- and C-terminal domain interface [polypeptide binding]; other site 886882015214 putative active site [active] 886882015215 MgATP binding site [chemical binding]; other site 886882015216 catalytic site [active] 886882015217 metal binding site [ion binding]; metal-binding site 886882015218 putative carbohydrate binding site [chemical binding]; other site 886882015219 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 886882015220 DNA-binding site [nucleotide binding]; DNA binding site 886882015221 Transcriptional regulators [Transcription]; Region: PurR; COG1609 886882015222 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 886882015223 putative dimerization interface [polypeptide binding]; other site 886882015224 putative ligand binding site [chemical binding]; other site 886882015225 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 886882015226 Beta-lactamase; Region: Beta-lactamase; pfam00144 886882015227 S-layer homology domain; Region: SLH; pfam00395 886882015228 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 886882015229 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 886882015230 Fe-S cluster binding site [ion binding]; other site 886882015231 active site 886882015232 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 886882015233 active site 886882015234 catalytic site [active] 886882015235 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 886882015236 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 886882015237 Berberine and berberine like; Region: BBE; pfam08031 886882015238 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 886882015239 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 886882015240 G1 box; other site 886882015241 putative GEF interaction site [polypeptide binding]; other site 886882015242 GTP/Mg2+ binding site [chemical binding]; other site 886882015243 Switch I region; other site 886882015244 G2 box; other site 886882015245 G3 box; other site 886882015246 Switch II region; other site 886882015247 G4 box; other site 886882015248 G5 box; other site 886882015249 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 886882015250 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 886882015251 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 886882015252 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 886882015253 Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840 886882015254 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882015255 dimerization interface [polypeptide binding]; other site 886882015256 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 886882015257 dimer interface [polypeptide binding]; other site 886882015258 putative CheW interface [polypeptide binding]; other site 886882015259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 886882015260 TPR motif; other site 886882015261 Tetratricopeptide repeat; Region: TPR_12; pfam13424 886882015262 binding surface 886882015263 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 886882015264 GTP-binding protein YchF; Reviewed; Region: PRK09601 886882015265 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 886882015266 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882015267 non-specific DNA binding site [nucleotide binding]; other site 886882015268 salt bridge; other site 886882015269 sequence-specific DNA binding site [nucleotide binding]; other site 886882015270 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882015271 non-specific DNA binding site [nucleotide binding]; other site 886882015272 salt bridge; other site 886882015273 sequence-specific DNA binding site [nucleotide binding]; other site 886882015274 DinB family; Region: DinB; cl17821 886882015275 Helix-turn-helix domain; Region: HTH_18; pfam12833 886882015276 YyzF-like protein; Region: YyzF; pfam14116 886882015277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882015278 S-adenosylmethionine binding site [chemical binding]; other site 886882015279 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 886882015280 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 886882015281 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 886882015282 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 886882015283 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 886882015284 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 886882015285 protein binding site [polypeptide binding]; other site 886882015286 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 886882015287 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 886882015288 YycH protein; Region: YycI; cl02015 886882015289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 886882015290 YycH protein; Region: YycH; pfam07435 886882015291 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 886882015292 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 886882015293 dimerization interface [polypeptide binding]; other site 886882015294 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 886882015295 putative active site [active] 886882015296 heme pocket [chemical binding]; other site 886882015297 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 886882015298 dimer interface [polypeptide binding]; other site 886882015299 phosphorylation site [posttranslational modification] 886882015300 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 886882015301 ATP binding site [chemical binding]; other site 886882015302 Mg2+ binding site [ion binding]; other site 886882015303 G-X-G motif; other site 886882015304 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 886882015305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882015306 active site 886882015307 phosphorylation site [posttranslational modification] 886882015308 intermolecular recognition site; other site 886882015309 dimerization interface [polypeptide binding]; other site 886882015310 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 886882015311 DNA binding site [nucleotide binding] 886882015312 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 886882015313 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 886882015314 G5 domain; Region: G5; pfam07501 886882015315 Peptidase family M23; Region: Peptidase_M23; pfam01551 886882015316 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 886882015317 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 886882015318 GDP-binding site [chemical binding]; other site 886882015319 ACT binding site; other site 886882015320 IMP binding site; other site 886882015321 replicative DNA helicase; Provisional; Region: PRK05748 886882015322 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 886882015323 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 886882015324 Walker A motif; other site 886882015325 ATP binding site [chemical binding]; other site 886882015326 Walker B motif; other site 886882015327 DNA binding loops [nucleotide binding] 886882015328 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 886882015329 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 886882015330 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 886882015331 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 886882015332 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 886882015333 DHH family; Region: DHH; pfam01368 886882015334 Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991 886882015335 MazG-like family; Region: MazG-like; pfam12643 886882015336 FOG: CBS domain [General function prediction only]; Region: COG0517 886882015337 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 886882015338 Transcriptional regulator [Transcription]; Region: LytR; COG1316 886882015339 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 886882015340 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 886882015341 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 886882015342 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 886882015343 Walker A/P-loop; other site 886882015344 ATP binding site [chemical binding]; other site 886882015345 Q-loop/lid; other site 886882015346 ABC transporter signature motif; other site 886882015347 Walker B; other site 886882015348 D-loop; other site 886882015349 H-loop/switch region; other site 886882015350 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 886882015351 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 886882015352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 886882015353 Walker A/P-loop; other site 886882015354 ATP binding site [chemical binding]; other site 886882015355 Q-loop/lid; other site 886882015356 ABC transporter signature motif; other site 886882015357 Walker B; other site 886882015358 D-loop; other site 886882015359 H-loop/switch region; other site 886882015360 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 886882015361 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 886882015362 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 886882015363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882015364 dimer interface [polypeptide binding]; other site 886882015365 conserved gate region; other site 886882015366 putative PBP binding loops; other site 886882015367 ABC-ATPase subunit interface; other site 886882015368 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 886882015369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 886882015370 dimer interface [polypeptide binding]; other site 886882015371 conserved gate region; other site 886882015372 putative PBP binding loops; other site 886882015373 ABC-ATPase subunit interface; other site 886882015374 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 886882015375 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 886882015376 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 886882015377 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 886882015378 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 886882015379 dimer interface [polypeptide binding]; other site 886882015380 ssDNA binding site [nucleotide binding]; other site 886882015381 tetramer (dimer of dimers) interface [polypeptide binding]; other site 886882015382 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 886882015383 YjzC-like protein; Region: YjzC; pfam14168 886882015384 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 886882015385 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 886882015386 Mechanosensitive ion channel; Region: MS_channel; pfam00924 886882015387 Protein of unknown function (DUF1256); Region: DUF1256; pfam06866 886882015388 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 886882015389 ParB-like nuclease domain; Region: ParB; smart00470 886882015390 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 886882015391 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 886882015392 P-loop; other site 886882015393 Magnesium ion binding site [ion binding]; other site 886882015394 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 886882015395 Magnesium ion binding site [ion binding]; other site 886882015396 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 886882015397 nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285 886882015398 ParB-like nuclease domain; Region: ParB; smart00470 886882015399 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 886882015400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882015401 S-adenosylmethionine binding site [chemical binding]; other site 886882015402 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 886882015403 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 886882015404 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 886882015405 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 886882015406 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 886882015407 trmE is a tRNA modification GTPase; Region: trmE; cd04164 886882015408 G1 box; other site 886882015409 GTP/Mg2+ binding site [chemical binding]; other site 886882015410 Switch I region; other site 886882015411 G2 box; other site 886882015412 Switch II region; other site 886882015413 G3 box; other site 886882015414 G4 box; other site 886882015415 G5 box; other site 886882015416 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 886882015417 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 886882015418 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 886882015419 G-X-X-G motif; other site 886882015420 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 886882015421 RxxxH motif; other site 886882015422 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 886882015423 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 886882015424 ribonuclease P; Reviewed; Region: rnpA; PRK00499 886882015425 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 886882015426 elongation factor Tu; Reviewed; Region: PRK00049 886882015427 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 886882015428 G1 box; other site 886882015429 GEF interaction site [polypeptide binding]; other site 886882015430 GTP/Mg2+ binding site [chemical binding]; other site 886882015431 Switch I region; other site 886882015432 G2 box; other site 886882015433 G3 box; other site 886882015434 Switch II region; other site 886882015435 G4 box; other site 886882015436 G5 box; other site 886882015437 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 886882015438 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 886882015439 Antibiotic Binding Site [chemical binding]; other site 886882015440 elongation factor G; Reviewed; Region: PRK00007 886882015441 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 886882015442 G1 box; other site 886882015443 putative GEF interaction site [polypeptide binding]; other site 886882015444 GTP/Mg2+ binding site [chemical binding]; other site 886882015445 Switch I region; other site 886882015446 G2 box; other site 886882015447 G3 box; other site 886882015448 Switch II region; other site 886882015449 G4 box; other site 886882015450 G5 box; other site 886882015451 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 886882015452 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 886882015453 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 886882015454 30S ribosomal protein S7; Validated; Region: PRK05302 886882015455 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 886882015456 S17 interaction site [polypeptide binding]; other site 886882015457 S8 interaction site; other site 886882015458 16S rRNA interaction site [nucleotide binding]; other site 886882015459 streptomycin interaction site [chemical binding]; other site 886882015460 23S rRNA interaction site [nucleotide binding]; other site 886882015461 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 886882015462 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 886882015463 Mg binding site [ion binding]; other site 886882015464 nucleotide binding site [chemical binding]; other site 886882015465 putative protofilament interface [polypeptide binding]; other site 886882015466 hypothetical protein; Provisional; Region: PRK04164 886882015467 CRISPR/Cas system-associated protein Csx16; Region: Csx16_III-U; cl09866 886882015468 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 886882015469 N-acetyl-D-glucosamine binding site [chemical binding]; other site 886882015470 catalytic residue [active] 886882015471 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 886882015472 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882015473 Interdomain contacts; other site 886882015474 Cytokine receptor motif; other site 886882015475 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 886882015476 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 886882015477 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 886882015478 active site 886882015479 PHP Thumb interface [polypeptide binding]; other site 886882015480 metal binding site [ion binding]; metal-binding site 886882015481 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 886882015482 generic binding surface II; other site 886882015483 generic binding surface I; other site 886882015484 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 886882015485 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 886882015486 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 886882015487 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 886882015488 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 886882015489 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 886882015490 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 886882015491 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 886882015492 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 886882015493 active site 886882015494 HIGH motif; other site 886882015495 nucleotide binding site [chemical binding]; other site 886882015496 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 886882015497 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 886882015498 active site 886882015499 KMSKS motif; other site 886882015500 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 886882015501 tRNA binding surface [nucleotide binding]; other site 886882015502 anticodon binding site; other site 886882015503 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 886882015504 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 886882015505 metal ion-dependent adhesion site (MIDAS); other site 886882015506 HIRAN domain; Region: HIRAN; pfam08797 886882015507 MoxR-like ATPases [General function prediction only]; Region: COG0714 886882015508 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882015509 Walker A motif; other site 886882015510 ATP binding site [chemical binding]; other site 886882015511 Walker B motif; other site 886882015512 arginine finger; other site 886882015513 CHC2 zinc finger; Region: zf-CHC2; cl17510 886882015514 DNA primase, catalytic core; Region: dnaG; TIGR01391 886882015515 Domain of unknown function (DUF3854); Region: DUF3854; pfam12965 886882015516 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 886882015517 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 886882015518 dimer interface [polypeptide binding]; other site 886882015519 ssDNA binding site [nucleotide binding]; other site 886882015520 tetramer (dimer of dimers) interface [polypeptide binding]; other site 886882015521 thymidine kinase; Provisional; Region: PRK04296 886882015522 hypothetical protein; Region: PHA01812 886882015523 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 886882015524 active site 886882015525 putative DNA-binding cleft [nucleotide binding]; other site 886882015526 dimer interface [polypeptide binding]; other site 886882015527 YtxC-like family; Region: YtxC; cl08500 886882015528 PemK-like protein; Region: PemK; pfam02452 886882015529 Protein of unknown function DUF91; Region: DUF91; cl00709 886882015530 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 886882015531 active site 886882015532 catalytic site [active] 886882015533 substrate binding site [chemical binding]; other site 886882015534 hypothetical protein; Provisional; Region: PRK09946 886882015535 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882015536 Zn2+ binding site [ion binding]; other site 886882015537 Mg2+ binding site [ion binding]; other site 886882015538 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 886882015539 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 886882015540 nucleotide binding pocket [chemical binding]; other site 886882015541 K-X-D-G motif; other site 886882015542 catalytic site [active] 886882015543 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 886882015544 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 886882015545 Dimer interface [polypeptide binding]; other site 886882015546 BRCT sequence motif; other site 886882015547 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 886882015548 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 886882015549 Catalytic site [active] 886882015550 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 886882015551 active site 886882015552 catalytic site [active] 886882015553 substrate binding site [chemical binding]; other site 886882015554 HD domain; Region: HD_3; cl17350 886882015555 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 886882015556 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 886882015557 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 886882015558 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 886882015559 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 886882015560 Walker A motif; other site 886882015561 ATP binding site [chemical binding]; other site 886882015562 Walker B motif; other site 886882015563 AAA domain; Region: AAA_31; pfam13614 886882015564 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 886882015565 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 886882015566 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 886882015567 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 886882015568 HerA helicase [Replication, recombination, and repair]; Region: COG0433 886882015569 Domain of unknown function DUF87; Region: DUF87; pfam01935 886882015570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882015571 ABC transporter signature motif; other site 886882015572 Walker B; other site 886882015573 D-loop; other site 886882015574 H-loop/switch region; other site 886882015575 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 886882015576 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 886882015577 active site 886882015578 metal binding site [ion binding]; metal-binding site 886882015579 AAA domain; Region: AAA_23; pfam13476 886882015580 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882015581 Walker A/P-loop; other site 886882015582 ATP binding site [chemical binding]; other site 886882015583 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 886882015584 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 886882015585 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 886882015586 cofactor binding site; other site 886882015587 DNA binding site [nucleotide binding] 886882015588 substrate interaction site [chemical binding]; other site 886882015589 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 886882015590 putative DNA binding site [nucleotide binding]; other site 886882015591 putative Zn2+ binding site [ion binding]; other site 886882015592 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 886882015593 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 886882015594 dimer interface [polypeptide binding]; other site 886882015595 putative radical transfer pathway; other site 886882015596 diiron center [ion binding]; other site 886882015597 tyrosyl radical; other site 886882015598 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09209 886882015599 Class I ribonucleotide reductase; Region: RNR_I; cd01679 886882015600 active site 886882015601 dimer interface [polypeptide binding]; other site 886882015602 catalytic residues [active] 886882015603 effector binding site; other site 886882015604 R2 peptide binding site; other site 886882015605 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 886882015606 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 886882015607 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 886882015608 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 886882015609 Probable transposase; Region: OrfB_IS605; pfam01385 886882015610 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 886882015611 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 886882015612 cofactor binding site; other site 886882015613 substrate interaction site [chemical binding]; other site 886882015614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 886882015615 S-adenosylmethionine binding site [chemical binding]; other site 886882015616 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 886882015617 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 886882015618 DNA binding residues [nucleotide binding] 886882015619 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882015620 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 886882015621 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 886882015622 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 886882015623 putative active site [active] 886882015624 PhoH-like protein; Region: PhoH; pfam02562 886882015625 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882015626 non-specific DNA binding site [nucleotide binding]; other site 886882015627 salt bridge; other site 886882015628 sequence-specific DNA binding site [nucleotide binding]; other site 886882015629 recombinase A; Provisional; Region: recA; PRK09354 886882015630 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 886882015631 hexamer interface [polypeptide binding]; other site 886882015632 Walker A motif; other site 886882015633 ATP binding site [chemical binding]; other site 886882015634 Walker B motif; other site 886882015635 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 886882015636 DHH family; Region: DHH; pfam01368 886882015637 DHHA1 domain; Region: DHHA1; pfam02272 886882015638 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 886882015639 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 886882015640 putative active site [active] 886882015641 putative NTP binding site [chemical binding]; other site 886882015642 putative nucleic acid binding site [nucleotide binding]; other site 886882015643 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 886882015644 active site 886882015645 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 886882015646 Predicted membrane protein (DUF2085); Region: DUF2085; pfam09858 886882015647 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882015648 salt bridge; other site 886882015649 non-specific DNA binding site [nucleotide binding]; other site 886882015650 sequence-specific DNA binding site [nucleotide binding]; other site 886882015651 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 886882015652 RNA binding site [nucleotide binding]; other site 886882015653 Response regulator receiver domain; Region: Response_reg; pfam00072 886882015654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882015655 active site 886882015656 phosphorylation site [posttranslational modification] 886882015657 intermolecular recognition site; other site 886882015658 dimerization interface [polypeptide binding]; other site 886882015659 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 886882015660 AAA domain; Region: AAA_30; pfam13604 886882015661 Family description; Region: UvrD_C_2; pfam13538 886882015662 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 886882015663 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 886882015664 Catalytic site [active] 886882015665 DNA topoisomerase III; Provisional; Region: PRK07726 886882015666 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 886882015667 active site 886882015668 putative interdomain interaction site [polypeptide binding]; other site 886882015669 putative metal-binding site [ion binding]; other site 886882015670 putative nucleotide binding site [chemical binding]; other site 886882015671 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 886882015672 DNA binding groove [nucleotide binding] 886882015673 domain I; other site 886882015674 phosphate binding site [ion binding]; other site 886882015675 domain II; other site 886882015676 domain III; other site 886882015677 nucleotide binding site [chemical binding]; other site 886882015678 catalytic site [active] 886882015679 domain IV; other site 886882015680 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 886882015681 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 886882015682 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 886882015683 AAA-like domain; Region: AAA_10; pfam12846 886882015684 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 886882015685 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 886882015686 Walker A motif; other site 886882015687 ATP binding site [chemical binding]; other site 886882015688 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 886882015689 30S subunit binding site; other site 886882015690 Replication-relaxation; Region: Replic_Relax; pfam13814 886882015691 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 886882015692 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 886882015693 Probable transposase; Region: OrfB_IS605; pfam01385 886882015694 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 886882015695 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 886882015696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882015697 non-specific DNA binding site [nucleotide binding]; other site 886882015698 salt bridge; other site 886882015699 sequence-specific DNA binding site [nucleotide binding]; other site 886882015700 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 886882015701 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 886882015702 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 886882015703 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 886882015704 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 886882015705 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 886882015706 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 886882015707 Walker A motif; other site 886882015708 ATP binding site [chemical binding]; other site 886882015709 Walker B motif; other site 886882015710 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 886882015711 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 886882015712 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 886882015713 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 886882015714 catalytic residues [active] 886882015715 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 886882015716 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882015717 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882015718 DNA binding residues [nucleotide binding] 886882015719 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 886882015720 ClpX C4-type zinc finger; Region: zf-C4_ClpX; smart00994 886882015721 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882015722 Walker A motif; other site 886882015723 ATP binding site [chemical binding]; other site 886882015724 Walker B motif; other site 886882015725 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 886882015726 PrgI family protein; Region: PrgI; pfam12666 886882015727 Domain of unknown function DUF87; Region: DUF87; pfam01935 886882015728 AAA-like domain; Region: AAA_10; pfam12846 886882015729 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 886882015730 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 886882015731 N-acetyl-D-glucosamine binding site [chemical binding]; other site 886882015732 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 886882015733 Peptidase family M23; Region: Peptidase_M23; pfam01551 886882015734 Protein of unknown function (DUF1178); Region: DUF1178; cl17833 886882015735 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 886882015736 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 886882015737 putative nicotinate phosphoribosyltransferase; Provisional; Region: PRK09198 886882015738 pre-B-cell colony-enhancing factor (PBEF)-like. The mammalian members of this group of nicotinate phosphoribosyltransferases (NAPRTases) were originally identified as genes whose expression is upregulated upon activation in lymphoid cells. In general; Region: PBEF_like; cd01569 886882015739 active site 886882015740 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 886882015741 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 886882015742 active site 886882015743 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 886882015744 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 886882015745 active site 886882015746 TROVE domain; Region: TROVE; pfam05731 886882015747 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 886882015748 metal ion-dependent adhesion site (MIDAS); other site 886882015749 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 886882015750 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 886882015751 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 886882015752 trimer interface [polypeptide binding]; other site 886882015753 active site 886882015754 outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022 886882015755 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 886882015756 AAA domain; Region: AAA_30; pfam13604 886882015757 Family description; Region: UvrD_C_2; pfam13538 886882015758 Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477 886882015759 active site 886882015760 catalytic residues [active] 886882015761 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882015762 Interdomain contacts; other site 886882015763 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882015764 Interdomain contacts; other site 886882015765 Cytokine receptor motif; other site 886882015766 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882015767 Interdomain contacts; other site 886882015768 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882015769 Interdomain contacts; other site 886882015770 Cytokine receptor motif; other site 886882015771 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882015772 Interdomain contacts; other site 886882015773 Cytokine receptor motif; other site 886882015774 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882015775 Interdomain contacts; other site 886882015776 Cytokine receptor motif; other site 886882015777 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 886882015778 Interdomain contacts; other site 886882015779 Cytokine receptor motif; other site 886882015780 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 886882015781 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 886882015782 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 886882015783 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 886882015784 active site 886882015785 (T/H)XGH motif; other site 886882015786 Protein of unknown function (DUF1385); Region: DUF1385; cl01595 886882015787 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882015788 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 886882015789 Walker A motif; other site 886882015790 ATP binding site [chemical binding]; other site 886882015791 Walker B motif; other site 886882015792 arginine finger; other site 886882015793 Uncharacterized conserved protein [Function unknown]; Region: COG4748 886882015794 Protein of unknown function DUF262; Region: DUF262; pfam03235 886882015795 Predicted phosphohydrolase (DHH superfamily) [General function prediction only]; Region: COG2404 886882015796 Domain of unknown function (DUF1792); Region: DUF1792; cl07392 886882015797 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 886882015798 HD domain; Region: HD_4; pfam13328 886882015799 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 886882015800 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 886882015801 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 886882015802 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 886882015803 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 886882015804 Probable transposase; Region: OrfB_IS605; pfam01385 886882015805 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 886882015806 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 886882015807 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 886882015808 Domain of unknown function (DUF3391); Region: DUF3391; pfam11871 886882015809 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 886882015810 active site 886882015811 metal binding site [ion binding]; metal-binding site 886882015812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 886882015813 Probable transposase; Region: OrfB_IS605; pfam01385 886882015814 DNA methylase; Region: N6_N4_Mtase; cl17433 886882015815 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 886882015816 DNA polymerase IV; Reviewed; Region: PRK03103 886882015817 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 886882015818 active site 886882015819 DNA binding site [nucleotide binding] 886882015820 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 886882015821 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 886882015822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882015823 non-specific DNA binding site [nucleotide binding]; other site 886882015824 salt bridge; other site 886882015825 sequence-specific DNA binding site [nucleotide binding]; other site 886882015826 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 886882015827 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 886882015828 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 886882015829 active site 886882015830 metal binding site [ion binding]; metal-binding site 886882015831 Protein of unknown function DUF262; Region: DUF262; pfam03235 886882015832 Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962 886882015833 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 886882015834 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 886882015835 Protein of unknown function (DUF1273); Region: DUF1273; cl01859 886882015836 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 886882015837 Bacterial RNase HI containing a hybrid binding domain (HBD) at the N-terminus; Region: RNase_HI_bacteria_HBD; cd09277 886882015838 RNA/DNA hybrid binding site [nucleotide binding]; other site 886882015839 active site 886882015840 FtsH Extracellular; Region: FtsH_ext; pfam06480 886882015841 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 886882015842 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 886882015843 Walker A motif; other site 886882015844 ATP binding site [chemical binding]; other site 886882015845 Walker B motif; other site 886882015846 arginine finger; other site 886882015847 Peptidase family M41; Region: Peptidase_M41; pfam01434 886882015848 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 886882015849 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 886882015850 active site 886882015851 Int/Topo IB signature motif; other site 886882015852 catalytic residues [active] 886882015853 DNA binding site [nucleotide binding] 886882015854 ADP-ribose binding site [chemical binding]; other site 886882015855 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 886882015856 thymidylate kinase; Validated; Region: tmk; PRK00698 886882015857 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 886882015858 TMP-binding site; other site 886882015859 ATP-binding site [chemical binding]; other site 886882015860 hypothetical protein; Provisional; Region: PRK09946 886882015861 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 886882015862 Zn2+ binding site [ion binding]; other site 886882015863 Mg2+ binding site [ion binding]; other site 886882015864 Part of AAA domain; Region: AAA_19; pfam13245 886882015865 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 886882015866 Kinase/pyrophosphorylase; Region: Kinase-PPPase; cl00780 886882015867 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 886882015868 N-acetyl-D-glucosamine binding site [chemical binding]; other site 886882015869 catalytic residue [active] 886882015870 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 886882015871 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 886882015872 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 886882015873 active site 886882015874 metal binding site [ion binding]; metal-binding site 886882015875 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 886882015876 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 886882015877 Probable transposase; Region: OrfB_IS605; pfam01385 886882015878 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 886882015879 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 886882015880 active site 886882015881 NTP binding site [chemical binding]; other site 886882015882 metal binding triad [ion binding]; metal-binding site 886882015883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882015884 non-specific DNA binding site [nucleotide binding]; other site 886882015885 salt bridge; other site 886882015886 sequence-specific DNA binding site [nucleotide binding]; other site 886882015887 Planctomycetes uncharacterized domain TIGR03009; Region: plancto_dom_2 886882015888 NAD-dependent DNA ligase LigA; Provisional; Region: ligA; PRK14351 886882015889 hypothetical protein; Provisional; Region: PRK06850 886882015890 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 886882015891 Ligand Binding Site [chemical binding]; other site 886882015892 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 886882015893 Protein of unknown function (DUF4046); Region: DUF4046; pfam13255 886882015894 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882015895 salt bridge; other site 886882015896 non-specific DNA binding site [nucleotide binding]; other site 886882015897 sequence-specific DNA binding site [nucleotide binding]; other site 886882015898 WGR domain; Region: WGR; cl01581 886882015899 ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell; Region: ADP_ribosyl; cl00283 886882015900 nad+ binding pocket [chemical binding]; other site 886882015901 Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269 886882015902 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 886882015903 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 886882015904 active site 886882015905 Int/Topo IB signature motif; other site 886882015906 catalytic residues [active] 886882015907 DNA binding site [nucleotide binding] 886882015908 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 886882015909 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 886882015910 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 886882015911 active site 886882015912 metal binding site [ion binding]; metal-binding site 886882015913 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 886882015914 nucleotide binding site/active site [active] 886882015915 HIT family signature motif; other site 886882015916 catalytic residue [active] 886882015917 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 886882015918 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 886882015919 Probable transposase; Region: OrfB_IS605; pfam01385 886882015920 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 886882015921 Peroxisomal membrane anchor protein (Pex14p) conserved region; Region: Pex14_N; pfam04695 886882015922 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 886882015923 Toxin SpoIISA, type II toxin-antitoxin system; Region: SpoIISA_toxin; pfam14171 886882015924 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 886882015925 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 886882015926 dimer interface [polypeptide binding]; other site 886882015927 ssDNA binding site [nucleotide binding]; other site 886882015928 tetramer (dimer of dimers) interface [polypeptide binding]; other site 886882015929 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 886882015930 Deoxyribonuclease NucA/NucB; Region: DNase_NucA_NucB; pfam14040 886882015931 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 886882015932 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 886882015933 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882015934 salt bridge; other site 886882015935 non-specific DNA binding site [nucleotide binding]; other site 886882015936 sequence-specific DNA binding site [nucleotide binding]; other site 886882015937 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882015938 non-specific DNA binding site [nucleotide binding]; other site 886882015939 salt bridge; other site 886882015940 sequence-specific DNA binding site [nucleotide binding]; other site 886882015941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 886882015942 RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279 886882015943 RNA/DNA hybrid binding site [nucleotide binding]; other site 886882015944 active site 886882015945 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 886882015946 GIY-YIG motif/motif A; other site 886882015947 active site 886882015948 catalytic site [active] 886882015949 metal binding site [ion binding]; metal-binding site 886882015950 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 886882015951 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 886882015952 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 886882015953 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 886882015954 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 886882015955 active site 886882015956 phosphorylation site [posttranslational modification] 886882015957 intermolecular recognition site; other site 886882015958 dimerization interface [polypeptide binding]; other site 886882015959 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 886882015960 DNA binding residues [nucleotide binding] 886882015961 apocytochrome f; Reviewed; Region: PRK02693 886882015962 capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689 886882015963 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 886882015964 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 886882015965 cofactor binding site; other site 886882015966 DNA binding site [nucleotide binding] 886882015967 substrate interaction site [chemical binding]; other site 886882015968 DNA-sulfur modification-associated; Region: DndB; cl17621 886882015969 S-layer homology domain; Region: SLH; pfam00395 886882015970 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 886882015971 Part of AAA domain; Region: AAA_19; pfam13245 886882015972 Family description; Region: UvrD_C_2; pfam13538 886882015973 lysophospholipid transporter LplT; Provisional; Region: PRK11195 886882015974 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 886882015975 putative substrate translocation pore; other site 886882015976 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 886882015977 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 886882015978 putative acyl-acceptor binding pocket; other site 886882015979 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 886882015980 acyl-activating enzyme (AAE) consensus motif; other site 886882015981 AMP binding site [chemical binding]; other site 886882015982 active site 886882015983 CoA binding site [chemical binding]; other site 886882015984 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 886882015985 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 886882015986 active site 886882015987 NTP binding site [chemical binding]; other site 886882015988 metal binding triad [ion binding]; metal-binding site 886882015989 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 886882015990 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 886882015991 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 886882015992 active site 886882015993 metal binding site [ion binding]; metal-binding site 886882015994 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 886882015995 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882015996 non-specific DNA binding site [nucleotide binding]; other site 886882015997 salt bridge; other site 886882015998 sequence-specific DNA binding site [nucleotide binding]; other site 886882015999 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 886882016000 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 886882016001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 886882016002 non-specific DNA binding site [nucleotide binding]; other site 886882016003 salt bridge; other site 886882016004 sequence-specific DNA binding site [nucleotide binding]; other site 886882016005 YopX protein; Region: YopX; cl09859 886882016006 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 886882016007 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 886882016008 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 886882016009 DNA binding residues [nucleotide binding] 886882016010 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 886882016011 DNA binding residues [nucleotide binding] 886882016012 Probable transposase; Region: OrfB_IS605; pfam01385 886882016013 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 886882016014 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 886882016015 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 886882016016 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 886882016017 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 886882016018 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 886882016019 active site 886882016020 metal binding site [ion binding]; metal-binding site 886882016021 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 886882016022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 886882016023 binding surface 886882016024 TPR motif; other site 886882016025 TPR repeat; Region: TPR_11; pfam13414 886882016026 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 886882016027 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 886882016028 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 886882016029 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 886882016030 AAA domain; Region: AAA_23; pfam13476 886882016031 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882016032 Walker A/P-loop; other site 886882016033 ATP binding site [chemical binding]; other site 886882016034 Q-loop/lid; other site 886882016035 ABC transporter signature motif; other site 886882016036 Walker B; other site 886882016037 D-loop; other site 886882016038 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 886882016039 Ligand Binding Site [chemical binding]; other site 886882016040 Domain of unknown function (DUF4262); Region: DUF4262; pfam14081 886882016041 Helix-turn-helix; Region: HTH_3; pfam01381 886882016042 non-specific DNA binding site [nucleotide binding]; other site 886882016043 salt bridge; other site 886882016044 sequence-specific DNA binding site [nucleotide binding]; other site 886882016045 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 886882016046 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK07636 886882016047 active site 886882016048 DNA binding site [nucleotide binding] 886882016049 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 886882016050 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 886882016051 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 886882016052 putative metal binding site [ion binding]; other site 886882016053 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 886882016054 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 886882016055 putative metal binding site [ion binding]; other site 886882016056 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 886882016057 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 886882016058 Probable transposase; Region: OrfB_IS605; pfam01385 886882016059 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 886882016060 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 886882016061 Protein of unknown function DUF262; Region: DUF262; pfam03235 886882016062 Peptidyl-tRNA hydrolase PTH2; Region: PTH2; pfam01981 886882016063 Peptidyl-tRNA hydrolase, type 2 (PTH2)_like . Peptidyl-tRNA hydrolase activity releases tRNA from the premature translation termination product peptidyl-tRNA. Two structurally different enzymes have been reported to encode such activity, Pth present in...; Region: PTH2_family; cd02407 886882016064 dimer interface [polypeptide binding]; other site 886882016065 putative active site [active] 886882016066 5'-3' exonuclease; Region: 53EXOc; smart00475 886882016067 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 886882016068 active site 886882016069 metal binding site 1 [ion binding]; metal-binding site 886882016070 putative 5' ssDNA interaction site; other site 886882016071 metal binding site 3; metal-binding site 886882016072 metal binding site 2 [ion binding]; metal-binding site 886882016073 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 886882016074 putative DNA binding site [nucleotide binding]; other site 886882016075 putative metal binding site [ion binding]; other site 886882016076 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 886882016077 tRNAHis guanylyltransferase; Region: Thg1; pfam04446 886882016078 Thg1 C terminal domain; Region: Thg1C; pfam14413 886882016079 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 886882016080 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 886882016081 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 886882016082 ssDNA binding site; other site 886882016083 generic binding surface II; other site 886882016084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 886882016085 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 886882016086 Walker A/P-loop; other site 886882016087 ATP binding site [chemical binding]; other site 886882016088 putative Mg++ binding site [ion binding]; other site 886882016089 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 886882016090 nucleotide binding region [chemical binding]; other site 886882016091 ATP-binding site [chemical binding]; other site 886882016092 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 886882016093 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK14704 886882016094 Class III ribonucleotide reductase; Region: RNR_III; cd01675 886882016095 effector binding site; other site 886882016096 active site 886882016097 Zn binding site [ion binding]; other site 886882016098 glycine loop; other site